Oncogene Proteins v-fos
Transforming proteins coded by fos oncogenes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a p55-kDa protein and the FBR-MSV v-fos gene encodes a p75-kDa fusion protein.
Genes, fos
Retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene protein c-fos codes for a nuclear protein which is involved in growth-related transcriptional control. The insertion of c-fos into FBJ-MSV or FBR-MSV induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-31 on the long arm of chromosome 14.
Proto-Oncogene Proteins c-fos
Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.
Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. (1/1311)
The Id subfamily of helix-loop-helix (HLH) proteins plays a fundamental role in the regulation of cellular proliferation and differentiation. Id proteins are thought to inhibit differentiation mainly through interaction with other HLH proteins and by blocking their DNA-binding activity. Members of the ternary complex factor (TCF) subfamily of ETS-domain proteins have key functions in regulating immediate-early gene expression in response to mitogenic stimulation. TCFs form DNA-bound complexes with the serum response factor (SRF) and are direct targets of MAP kinase (MAPK) signal transduction cascades. In this study we demonstrate functional interactions between Id proteins and TCFs. Ids bind to the ETS DNA-binding domain and disrupt the formation of DNA-bound complexes between TCFs and SRF on the c-fos serum response element (SRE). Inhibition occurs by disrupting protein-DNA interactions with the TCF component of this complex. In vivo, the Id proteins cause down-regulation of the transcriptional activity mediated by the TCFs and thereby block MAPK signalling to SREs. Therefore, our results demonstrate a novel facet of Id function in the coordination of mitogenic signalling and cell cycle entry. (+info)Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. (2/1311)
Ras proteins can activate at least three classes of downstream target proteins: Raf kinases, phosphatidylinositol-3 phosphate (PI3) kinase, and Ral-specific guanine nucleotide exchange factors (Ral-GEFs). In NIH 3T3 cells, activated Ral-GEFs contribute to Ras-induced cell proliferation and oncogenic transformation by complementing the activities of Raf and PI3 kinases. In PC12 cells, activated Raf and PI3 kinases mediate Ras-induced cell cycle arrest and differentiation into a neuronal phenotype. Here, we show that in PC12 cells, Ral-GEF activity acts opposite to other Ras effectors. Elevation of Ral-GEF activity induced by transfection of a mutant Ras protein that preferentially activates Ral-GEFs, or by transfection of the catalytic domain of the Ral-GEF Rgr, suppressed cell cycle arrest and neurite outgrowth induced by nerve growth factor (NGF) treatment. In addition, Rgr reduced neurite outgrowth induced by a mutant Ras protein that preferentially activates Raf kinases. Furthermore, inhibition of Ral-GEF activity by expression of a dominant negative Ral mutant accelerated cell cycle arrest and enhanced neurite outgrowth in response to NGF treatment. Ral-GEF activity may function, at least in part, through inhibition of the Rho family GTPases, CDC42 and Rac. In contrast to Ras, which was activated for hours by NGF treatment, Ral was activated for only approximately 20 min. These findings suggest that one function of Ral-GEF signaling induced by NGF is to delay the onset of cell cycle arrest and neurite outgrowth induced by other Ras effectors. They also demonstrate that Ras has the potential to promote both antidifferentiation and prodifferentiation signaling pathways through activation of distinct effector proteins. Thus, in some cell types the ratio of activities among Ras effectors and their temporal regulation may be important determinants for cell fate decisions between proliferation and differentiation. (+info)Thyroid hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal growth factor in cultured cells. (3/1311)
We have examined the effects of l-thyroxine (T4) on the activation of signal transducer and activator of transcription 3 (STAT3) and on the STAT3-dependent induction of c-Fos expression by epidermal growth factor (EGF). T4, at a physiological concentration of 100 nM, caused tyrosine phosphorylation and nuclear translocation (i.e. activation) of STAT3 in HeLa cells in as little as 10-20 min. Activation by T4 of STAT3 was maximal at 30 min (15+/-4-fold enhancement; mean+/-S.E.M.) in 18 experiments. This effect was reproduced by T4-agarose (100 nM) and blocked by CGP 41251, genistein, PD 98059 and geldanamycin, inhibitors of protein kinase C (PKC), protein tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK) kinase and Raf-1 respectively. Tyrosine-phosphorylated MAPK also appeared in nuclear fractions within 10 min of treatment with T4. In the nuclear fraction of T4-treated cells, MAPK immunoprecipitate also contained STAT3. The actions of T4 were similar in HeLa and CV-1 cells, which lack thyroid hormone receptor (TR), and in TR-replete skin fibroblasts (BG-9). T4 also potentiated the EGF-induced nuclear translocation of activated STAT1alpha and STAT3 and enhanced the EGF-stimulated expression of c-Fos. Hormone potentiation of EGF-induced signal transduction and c-Fos expression was inhibited by CGP 41251, geldanamycin and PD 98059. Therefore the non-genomically induced activation by T4 of STAT3, and the potentiation of EGF by T4, require activities of PKC, PTK and an intact MAPK pathway. (+info)Activation of c-fos promoter by Gbetagamma-mediated signaling: involvement of Rho and c-Jun N-terminal kinase. (4/1311)
Several extracellular stimuli mediated by G protein-coupled receptors activate c-fos promoter. Recently, we and other groups have demonstrated that signals from G protein-coupled receptors stimulate mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK. The activation of these three MAPKs is mediated in part by the G protein betagamma subunit (Gbetagamma). In this study, we characterized the signals from Gbetagamma to c-fos promoter using transient transfection of c-fos luciferase into human embryonal kidney 293 cells. Activation of m2 muscarinic acetylcholine receptor and overexpression of Gbetagamma, but not constitutively active Galphai2, stimulated c-fos promoter activity. The c-fos promoter activation by m2 receptor and Gbetagamma was inhibited by beta-adrenergic receptor kinase C-terminal peptide (betaARKct), which functions as a Gbetagamma antagonist. MEK1 inhibitor PD98059 and kinase-deficient mutant of JNK kinase, but not p38 MAPK inhibitor SB203580, attenuated the m2 receptor- and Gbetagamma-induced c-fos promoter activation. Activated mutants of Ras and Rho stimulated the c-fos promoter activity, and the dominant negative mutants of Ras and Rho inhibited the c-fos promoter activation by m2 receptor and Gbetagamma. Moreover, c-fos promoter activation by m2 receptor, Gbetagamma, and active Rho, but not active Ras, was inhibited by botulinum C3 toxin. These data indicated that both Ras- and Rho-dependent signaling pathways are essential for c-fos promoter activation mediated by Gbetagamma. (+info)Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum. (5/1311)
AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. METHODS: Northern and dot blotting, dual wavelength thin layer chromatography scanner, were used in this study. RESULTS: Lindane 30 mg.kg-1 given by intragastric gavage (i.g.) increased the expression of c-fos gene to 146 mm2 in rat cerebrum 1 h after treatment. Tet 1, 2, and 4 mg.kg-1 given by i.g. 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Expressed genes reached only 86, 40, and 39 mm2, respectively. CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist-lindane. (+info)The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. (6/1311)
Orexin-A and orexin-B (the hypocretins) are recently described neuropeptides suggested to have a physiological role in the regulation of food intake in the rat. We compared the orexigenic effect of the orexins administered intracerebroventricular (ICV) with other known stimulants of food intake, one strong, neuropeptide Y (NPY), and two weaker, melanin-concentrating hormone (MCH) and galanin. Orexin-A consistently stimulated food intake, but orexin-B only on occasions. Both peptides stimulated food intake significantly less than NPY, but to a similar extent to MCH (2 h food intake: NPY 3 nmol, 7.2+/-0.9 g vs saline, 1.5+/-0.2 g, P<0.001, MCH 3 nmol, 3.2+/-0.8 g vs saline, P<0.01, orexin-B 30 nmol, 2. 6+/-0.5 g vs saline, P=0.11) and to galanin (1 h food intake: galanin 3 nmol, 2.0+/-0.4 g vs saline, 0.8+/-0.2 g, P<0.05, orexin-A 3 nmol 2.2+/-0.4 g vs saline, P<0.01; 2 hour food intake: orexin-B 3 nmol, 2.4+/-0.3 g vs saline, 1.3+/-0.2 g, P<0.05). Following ICV orexin-A, hypothalamic c-fos, a maker of neuronal activation, was highly expressed in the paraventricular nucleus (PVN), and the arcuate nucleus (P<0.005 for both). IntraPVN injection of orexin-A stimulated 2 h food intake by one gram (orexin-A 0.03 nmol, 1.6+/-0. 3 g vs saline, 0.5+/-0.3 g, P<0.005). These findings support the suggestion that the orexins stimulate food intake. However, this effect is weak and may cast doubt upon their physiological importance in appetite regulation in the rat. (+info)Human SWI-SNF component BRG1 represses transcription of the c-fos gene. (7/1311)
Yeast and mammalian SWI-SNF complexes regulate transcription through active modification of chromatin structure. Human SW-13 adenocarcinoma cells lack BRG1 protein, a component of SWI-SNF that has a DNA-dependent ATPase activity essential for SWI-SNF function. Expression of BRG1 in SW-13 cells potentiated transcriptional activation by the glucocorticoid receptor, which is known to require SWI-SNF function. BRG1 also specifically repressed transcription from a transfected c-fos promoter and correspondingly blocked transcriptional activation of the endogenous c-fos gene. Mutation of lysine residue 798 in the DNA-dependent ATPase domain of BRG1 significantly reduced its ability to repress c-fos transcription. Repression by BRG1 required the cyclic AMP response element of the c-fos promoter but not nearby binding sites for Sp1, YY1, or TFII-I. Using human C33A cervical carcinoma cells, which lack BRG1 and also express a nonfunctional Rb protein, transcriptional repression by BRG1 was weak unless wild-type Rb was also supplied. Interestingly, Rb-dependent repression by BRG1 was found to take place through a pathway that is independent of transcription factor E2F. (+info)Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy. (8/1311)
Quercetin, a widely distributed bioflavonoid, inhibited DNA synthesis in regenerating liver after partial hepatectomy. This inhibition was accompanied by apoptosis, evidenced by in situ end-labeling and gel electrophoresis of DNA fragmentation. Characteristic DNA fragmentation was detected as early as 2 h after injection. Northern blot analysis revealed that quercetin induced the increases in c-fos and p21WAF1CIP1 mRNA levels within 2 h. The expression of p21 protein was also enhanced, while p53 mRNA and protein levels were not affected by quercetin. These results suggest that quercetin-induced apoptosis is associated with the increase in c-fos mRNA level and the upregulation of p21 mRNA and protein expression, probably in a p53-independent pathway. (+info)Oncogene proteins v-fos are a family of transcription factors that play a role in cell growth, differentiation, and oncogenic transformation, and are involved in the development of various types of cancer when they are constitutively activated or overexpressed.
An oncogene protein, specifically the v-fos protein, is a product of the v-fos gene found in the FBJ murine osteosarcoma virus. This viral oncogene can transform cells and cause cancer in animals. The normal cellular counterpart of v-fos is the c-fos gene, which encodes a nuclear protein that forms a heterodimer with other proteins to function as a transcription factor, regulating the expression of target genes involved in various cellular processes such as proliferation, differentiation, and transformation.
However, when the v-fos gene is integrated into the viral genome and expressed at high levels, it can lead to unregulated and constitutive activation of these cellular processes, resulting in oncogenic transformation and tumor formation. The v-fos protein can interact with other cellular proteins and modify their functions, leading to aberrant signaling pathways that contribute to the development of cancer.
FOS (v-fos FBJ murine osteosarcoma viral oncogene homolog) genes are a family of transcription factor genes that encode proteins involved in cellular processes such as proliferation, differentiation, and transformation in response to various stimuli.
I'm happy to help! However, I believe there might be a slight error in your question. The correct term is "FOS" (for immediate-early gene Fos), not "fos genes." Here's the definition of the FOS protein and its associated gene:
FOS is a transcription factor that forms a complex with proteins JUN and JUND, forming the AP-1 (Activator Protein 1) transcription factor complex. The FOS protein plays a crucial role in regulating cell growth, differentiation, and transformation. It binds to specific DNA sequences in the promoter regions of target genes and modulates their expression.
The FOS gene is located on human chromosome 14 (14q21-31) and encodes the FOS protein. The FOS gene belongs to a family of immediate-early genes, which are rapidly activated in response to various extracellular signals such as growth factors, cytokines, and stress. Once activated, these genes regulate the expression of downstream target genes involved in various cellular processes, including proliferation, differentiation, and survival.
I hope this clarifies your question! If you have any more questions or need further information, please don't hesitate to ask.
Proto-oncogene proteins c-Fos are nuclear phosphoproteins that form a heterodimeric transcription factor complex, AP-1, involved in cell proliferation, differentiation, and transformation in response to various stimuli, such as growth factors and mitogens.
Proto-oncogene proteins, such as c-Fos, are normal cellular proteins that play crucial roles in various biological processes including cell growth, differentiation, and survival. They can be activated or overexpressed due to genetic alterations, leading to the formation of cancerous cells. The c-Fos protein is a nuclear phosphoprotein involved in signal transduction pathways and forms a heterodimer with c-Jun to create the activator protein-1 (AP-1) transcription factor complex. This complex binds to specific DNA sequences, thereby regulating the expression of target genes that contribute to various cellular responses, including proliferation, differentiation, and apoptosis. Dysregulation of c-Fos can result in uncontrolled cell growth and malignant transformation, contributing to tumor development and progression.
C-fos-induced growth factor
"Entrez Gene: FIGF c-fos induced growth factor (vascular endothelial growth factor D)". Stacker SA, Caesar C, Baldwin ME, ... Orlandini M, Marconcini L, Ferruzzi R, Oliviero S (Oct 1996). "Identification of a c-fos-induced gene that is related to the ... gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes". Genomics. 47 (2): 207-16. doi:10.1006/ ... is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a ...
FOSL2
Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene. The Fos gene family consists of 4 ... "Entrez Gene: FOSL2 FOS-like antigen 2". Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (March 1990). "Isolation of human ... Molven A, Houge G, Berger R (November 1996). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2 ... members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN ...
FOSL1
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. The Fos gene family consists of 4 ... "Entrez Gene: FOSL1 FOS-like antigen 1". Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). " ... Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (Oct 1993). "Reverse mapping of the gene encoding the human fos-related ... Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression ...
Reward system
The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits ... The net result is c-fos gene repression. Figure 4: Epigenetic basis of drug regulation of gene expression Hitchcock LN, Lattal ... as indexed by the induced expression of c-Fos, an immediate early gene. Furthermore, inhibition of one hotspot results in the ... the induction of CDK5 gene expression occurs together with suppression of the G9A gene coding for dimethyltransferase acting on ...
S100A7A
"Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos". Genes Dev. 27 (18): 1959-73. doi:10.1101/gad.223339.113. ... gene duplications within the region of the S100 gene cluster on human chromosome 1q21". J. Mol. Evol. 56 (4): 397-406. Bibcode: ... "Entrez Gene: S100 calcium binding protein A7A". Wolf R, Mirmohammadsadegh A, Walz M, Lysa B, Tartler U, Remus R, Hengge U, ... "Entrez Gene: S100a7a S100 calcium binding protein". Briso EM, Guinea-Viniegra J, Bakiri L, Rogon Z, Petzelbauer P, Eils R, Wolf ...
Farhad Hafezi
Whilst studying in the Zürich laboratory, Hafezi identified the first known gene, c-Fos, that the absence of which could ... Fra1 can function in lieu of c-Fos to promote light-induced retinal photoreceptor death - work that was published in Genes & ... c-Fos and Fra1 are both components of the transcription factor AP-1, and in the year 2000, Hafezi and his colleagues presented ... Hafezi F, Steinbach JP, Marti A, Munz K, Wang ZQ, Wagner EF, Aguzzi A, Reme CE (1997). "The absence of c-fos prevents light- ...
USF2
"Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting". Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, ... Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene. This gene encodes a member of the basic ... USF2 has been shown to interact with USF1 (human gene), PPRC1 and BRCA1. The USF2 gene is repressed by the microRNA miR-10a. ... flanking gene contributes to basal transcriptional gene activation". Biochemical Pharmacology. 65 (7): 1087-96. doi:10.1016/ ...
Activating transcription factor
Genes include ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, ATF7, ATFx. van Dam H, Castellazzi M (2001). "Distinct roles of Jun : Fos and ... whereas it turned out later that some of them might be more similar to AP-1-like factors such as c-Jun or c-Fos. In general, ... Gene. 273 (1): 1-11. doi:10.1016/S0378-1119(01)00551-0. ISSN 0378-1119. PMID 11483355. Green, M. R.; Persengiev, S. P. (2003-06 ...
KIN (gene)
2000). "UV-Induced stabilization of c-fos and other short-lived mRNAs". Mol. Cell. Biol. 20 (10): 3616-25. doi:10.1128/MCB. ... DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene. The protein encoded by this gene is a ... "Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)". Biard DS, Saintigny Y, Maratrat M, et al. (1997 ... 2003). "Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication". Proc. Natl. ...
FOSB
... gene. The FOS gene family consists of four members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins ... The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits ... to acetylate histones and facilitate gene activation. This is known to occur on many genes including fosB and c-fos in response ... The net result is c-fos gene repression. Figure 4: Epigenetic basis of drug regulation of gene expression Nestler EJ, Barrot M ...
XBP1
... required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos ... X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located ... "Entrez Gene: XBP1 X-box binding protein 1". Liou HC, Boothby MR, Finn PW, Davidon R, Nabavi N, Zeleznik-Le NJ, Ting JP, ... The expression of this protein is required for the transcription of a subset of class II major histocompatibility genes. ...
TET enzymes
The TET2 protein lacks a CXXC domain, but the IDAX gene, that's a neighbor of the TET2 gene, encodes a CXXC4 protein. IDAX is ... Focus on c-Fos, Egr1 and Arc". Front Behav Neurosci. 12: 79. doi:10.3389/fnbeh.2018.00079. PMC 5932360. PMID 29755331. ... This included more than 2,000 differentially methylated genes at 24 hours after training, with over 500 genes being ... preferring gene bodies of highly expressed genes and enhancers. The three mammalian DNA methyltransferases (DNMTs) show a ...
DNA damage-inducible transcript 3
Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... As a transcription factor, CHOP can regulate the expression of many anti-apoptotic and pro-apoptotic genes, including genes ... November 1992). "Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)". Genes, ...
Bryant Villeponteau
Feng, J.L., and Villeponteau, B. (1990). Serum stimulation of the c-fos enhancer induces reversible changes in c-fos chromatin ... Heterchromatin is a repressor of gene expression and its loss leads to inappropriate gene expression with senescence. The model ... Irving, J., Feng, J., Wistrom, C., Pikaart, M., and Villeponteau, B. (1992). An altered repertoire of fos/jun (AP-1) at the ... Villeponteau, B., Landes, G.M., Pankratz, M.J., and Martinson, H.G. (1982). The chicken beta globin gene region. Delineation of ...
Kua-UEV
November 2000). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome ... Rothofsky ML, Lin SL (August 1997). "CROC-1 encodes a protein which mediates transcriptional activation of the human FOS ... November 2000). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome ... "Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1". Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand ...
Joseph Takahashi
Kornhauser, J.M.; Nelson, D.E.; Mayo, K.E.; Takahashi, J.S. (1990). "Photic and circadian regulation of c-fos gene expression ... "Gene Discovered in Mice that Regulates Biological Clock". Chicago Tribune. April 29, 1994. "Found in Mouse: The Gene of a Night ... This revealed that the gene is closely related to the gene doubletime (dbt) in Drosophila, and casein kinase 1 epsilon (CKIe) ... Such a discovery influenced them to pursue exploration of the clock gene's role in appetite and energy. In Clock mutant mice, ...
Immediate early gene
The earliest identified and best characterized IEGs include c-fos, c-myc and c-jun, genes that were found to be homologous to ... Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular ... Silencing of IE gene expression through antisense oligonucleotides, RNA interference, and gene-targeting ribosomes have been ... IEGs are distinct from "late response" genes, which can only be activated later, following the synthesis of early response gene ...
TEC (gene)
March 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood. 91 (5): 1496 ... making it likely these two kinase genes arose through the process of gene-duplication. Tec family kinases are involved in the ... "Entrez Gene: TEC tec protein tyrosine kinase". Schmidt U, Boucheron N, Unger B, Ellmeier W (May 2004). "The role of Tec family ... TEC (gene) has been shown to interact with: ARHGEF12, CD117, DOK1, GNA12, Janus kinase 2, and Suppressor of cytokine signaling ...
UBE2V1
The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto- ... Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion ... Gene. 195 (2): 141-9. doi:10.1016/S0378-1119(97)00097-8. PMID 9305758. "Entrez Gene: UBE2V1 ubiquitin-conjugating enzyme E2 ... "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome Res. 10 (11): ...
JunD
Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex ... Transcription factor JunD is a protein that in humans is encoded by the JUND gene. The protein encoded by this intronless gene ... "Entrez Gene: JUND jun D proto-oncogene". Hyman SE, Malenka RC, Nestler EJ (2006). "Neural mechanisms of addiction: the role of ...
Transcription factor Jun
It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was ... Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, ... Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped ...
Dextroamphetamine
The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits ... to acetylate histones and facilitate gene activation. This is known to occur on many genes including fosB and c-fos in response ... The net result is c-fos gene repression. Figure 4: Epigenetic basis of drug regulation of gene expression Nestler EJ (December ... Recent evidence has shown that ΔFosB also represses the c-fos gene that helps create the molecular switch-from the induction of ...
Amphetamine
The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits ... to acetylate histones and facilitate gene activation. This is known to occur on many genes including fosB and c-fos in response ... The net result is c-fos gene repression. Figure 4: Epigenetic basis of drug regulation of gene expression Nestler EJ (December ... Recent evidence has shown that ΔFosB also represses the c-fos gene that helps create the molecular switch-from the induction of ...
Behavioral epigenetics
The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits ... Reduced gene expressions were associated with methylations of those genes and hypomethylation was found for genes involved in ... to acetylate histones and facilitate gene activation. This is known to occur on many genes including fosB and c-fos in response ... The net result is c-fos gene repression. Figure 4: Epigenetic basis of drug regulation of gene expression Nestler EJ (December ...
Methamphetamine
... genes, activating those genes in the nucleus accumbens (NAc). c-fos is well known to be important in addiction. The ccr2 gene ... The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits ... to acetylate histones and facilitate gene activation. This is known to occur on many genes including fosB and c-fos in response ... The net result is c-fos gene repression. Figure 4: Epigenetic basis of drug regulation of gene expression Nestler EJ (December ...
Adderall
The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits ... to acetylate histones and facilitate gene activation. This is known to occur on many genes including fosB and c-fos in response ... The net result is c-fos gene repression. Figure 4: Epigenetic basis of drug regulation of gene expression Nestler EJ (December ... Recent evidence has shown that ΔFosB also represses the c-fos gene that helps create the molecular switch-from the induction of ...
RUNX1
In humans, the gene RUNX1 is 260 kilobases (kb) in length, and is located on chromosome 21 (21q22.12). The gene can be ... RUNX1 has been shown to interact with: C-Fos, C-jun, SUV39H1 TLE1, and VDR. Stat3 RUNX2 RUNX3 GRCh38: Ensembl release 89: ... to chromosomal translocation of the RUNX1 gene with the ETO / MTG8 / RUNX1T1 gene located on chromosome 8q22, t(8; 21), ... cloned the human RUNX1 gene; RUNX1 was found to be rearranged in the leukemic cell DNAs from t(8;21)(q22;q22) AML patients. ...
JUNB
"Entrez Gene: JUNB jun B proto-oncogene". Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) ... Hsu JC, Bravo R, Taub R (1992). "Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase ... Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and ... Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (1990). "Isolation of human cDNA clones of jun-related genes, jun-B ...
Chloride anion exchanger
"LPA stimulates intestinal DRA gene transcription via LPA2 receptor, PI3K/AKT, and c-Fos-dependent pathway". American Journal of ... "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic ... "Entrez Gene: SLC26A3 solute carrier family 26, member 3". Sterling D, Brown NJ, Supuran CT, Casey JR (November 2002). "The ... Mutations in this gene have been associated with congenital chloride diarrhoea, a treatable disease. The congenital absence of ...
De novo protein synthesis theory of memory formation
Sheng, M., & Greenberg, M. E. (1990). The regulation and function of c-fos and other immediate early genes in the nervous ... Since then, a wealth of research has been done to clarify the mechanisms, genes, and proteins involved in the physiological ... Many genes are upregulated during sleep, and therefore there is a possibility that protein synthesis is active in sleep- ... others suggest that the genes are byproducts of the LTP signaling pathway and are not directly involved in LTP. However, ...
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and...
... c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A, Egr-1, Zif268); and the constitutive transcription factors ( ... CTFs) CREB, CREM, ATF-2 and SRF as they pertain to gene … ... control of gene expression by Jun, Fos and Krox, and CREB/ATF ... This article reviews findings up to the end of 1997 about the inducible transcription factors (ITFs) c-Jun, JunB, JunD, c-Fos, ... ATF-2 and SRF as they pertain to gene expression in the mammalian nervous system. In the first part we consider basic facts ...
Gene P01100 | Protein FOS - Overview | canSAR Black
Protein FOS , Proto-oncogene c-Fos - Also known as FOS_HUMAN, FOS, G0S7. Nuclear phosphoprotein which forms a tight but non- ... Also known as FOS_HUMAN, FOS, G0S7. Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/ ... Also known as FOS_HUMAN, FOS, G0S7. Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/ ... In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta ...
C-fos-induced growth factor - Wikipedia
"Entrez Gene: FIGF c-fos induced growth factor (vascular endothelial growth factor D)". Stacker SA, Caesar C, Baldwin ME, ... Orlandini M, Marconcini L, Ferruzzi R, Oliviero S (Oct 1996). "Identification of a c-fos-induced gene that is related to the ... gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes". Genomics. 47 (2): 207-16. doi:10.1006/ ... is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a ...
Addgene: pFUW-tetO- FOS
Filipe Pereiras lab contains the insert Fos proto-oncogene, AP-1 transcription factor subunit and is published in Cell Rep. ... Gene/Insert * Gene/Insert name. Fos proto-oncogene, AP-1 transcription factor subunit ... pFUW-tetO- FOS was a gift from Filipe Pereira (Addgene plasmid # 125598 ; http://n2t.net/addgene:125598 ; RRID:Addgene_125598) ...
Identification and validation of oxidative stress and immune-related hub genes in Alzheimer's disease through bioinformatics...
The immune-related DEOSGs and hub genes were identified by weighted gene co-expression network analysis (WGCNA) and protein- ... Enrichment analysis was performed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. The diagnostic value of hub ... 27 gene modules were obtained through WGCNA and turquoise module was the most relevant module. We obtained 66 immune-related ... Investigation of hub genes for the development of potential therapeutic targets and candidate biomarkers is warranted. The ...
Long-term memory encoding engram neurons are established by the transcriptional cycling | ScienceDaily
Researchers found that ERK activity is increased during rest intervals to induce transcriptional cycling between c-Fos and CREB ... Genes essential for long-term memory formation. Controls gene expression necessary for memory formation. ... By repeating training, it became clear that a transcription cycle such as c-fos expressing CREB and CREB expressing c-fos was ... and expresses c-fos(3). c-fos is also a transcription factor, which is activated by MAPK and expresses CREB. ...
A Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation | Journal of Neuroscience
Some genes, such asc-fos and ania-5, are highly upregulated within 30 min, whereas others, such as ania-4 and ania-6, take 2 hr ... The figure is roughly organized so that more rapidly induced genes are on the left of more slowly induced genes, and genes with ... Although bothc-fos and dynorphin mRNAs are believed to respond to phosphorylation of CREB in striatum (Cole et al., 1995),c-fos ... Other genes, such as narp and preprodynorphin, take longer to reach peak induction; these are shown in Figure 5B. All genes ...
Differential CO<sub>2</sub>-induced c-fos gene expression in the nucleus tractus solitarii of inbred mouse...
CO2-induced increase in c-fos gene expression was significantly (P , 0.01) greater in NTS regions of B6 compared with C3 mice. ... Tankersley, C. G., Haxhiu, M. A., & Gauda, E. B. (2002). Differential CO2-induced c-fos gene expression in the nucleus tractus ... Differential CO2-induced c-fos gene expression in the nucleus tractus solitarii of inbred mouse strains. Journal of applied ... CO2-induced increase in c-fos gene expression was significantly (P , 0.01) greater in NTS regions of B6 compared with C3 mice. ...
Fos
View Fos allele: origin, molecular description, gene associations, and references. ... FosCreER, FosCreER, Fos-CreER, FosCreERT2, FosCreERT2, Fos-CreERT2. Gene:. Fos Location: Chr12:85520664-85524047 bp, + strand ... Fostm1.1(cre/ERT2)Luo expression driven by 1 gene Knock-in expression driven by:. Organism. Driver Gene. Note. ... followed by an FRT5-flanked pSV40-NeoR-pA cassette into the translational start site of the FBJ osteosarcoma oncogene gene (Fos ...
Erratum: Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in...
Erratum: Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in ... Erratum: Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in ... Erratum: Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in ... Erratum : Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in ...
c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1...
T1 - c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1 ... c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1- ... c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1- ... c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1- ...
Regulation of fos-lacZ fusion gene expression in primary mouse epidermal keratinocytes isolated from transgenic mice<...
This gene construct contains the entire upstream regulatory sequence of c-fos, and expression of the endogenous and fusion gene ... This gene construct contains the entire upstream regulatory sequence of c-fos, and expression of the endogenous and fusion gene ... This gene construct contains the entire upstream regulatory sequence of c-fos, and expression of the endogenous and fusion gene ... This gene construct contains the entire upstream regulatory sequence of c-fos, and expression of the endogenous and fusion gene ...
![VEGFD vascular endothelial growth factor D [Homo sapiens (human)] - Gene - NCBI](data:image/png;base64,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)
VEGFD vascular endothelial growth factor D [Homo sapiens (human)] - Gene - NCBI
c-fos induced growth factor (vascular endothelial growth factor D). NCBI Reference Sequences (RefSeq) Go to the top of the page ... Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side ... Gene Ontology Provided by GOA Function. Evidence Code. Pubs. enables chemoattractant activity IBA Inferred from Biological ... GeneRIFs: Gene References Into Functions Whats a GeneRIF? * Vascular endothelial growth factor-D plasma levels in fluid ...
Cancer Genes | CancerQuest
A diagram showing the major cancer genes for some cancers. The larger the ... FOS. Transcription factor for API. Osteosarcoma. 68 69 FES. Tyrosine kinase. Sarcoma. 70 71 ... Cancer Genes A diagram showing the major cancer genes for some cancers. The larger the gene name, the more frequently that gene ... This process can involve large amounts of DNA and can affect many genes. The movement of a gene or group of genes to a ...
Virus with a mission to destroy tumours | New Scientist
They will be taking part in the worlds first attempt to treat breast tumours directly through gene therapy. But the ... a protein that triggers genes into action. Holt and Arteaga do not know which particular set of genes c-fos switches on in ... The virus is engineered so that the gene against c-fos will only be activated, or expressed, in breast cells. This should ... These sabotage protein production by disrupting the journey of the instructions from the c-fos gene on their way across the ...
Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network...
Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein–protein interaction ... Western blotting and qRT–PCR were used to verify the expression of crucial target genes at the protein and RNA levels, ... Network pharmacology analysis was used to screen the target genes of SQP for NASH treatment based on public databases. ... PPI) analysis were used to search for crucial target genes and mechanisms. UPLC–MS/MS was used to verify the active ...
ELK4 ETS transcription factor ELK4 [Homo sapiens (human)] - Gene - NCBI
Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex Title: Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA ... Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side ... Gene type. protein coding. RefSeq status. REVIEWED. Organism. Homo sapiens Lineage. Eukaryota; Metazoa; Chordata; Craniata; ... GeneRIFs: Gene References Into Functions Whats a GeneRIF? * ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression ...
Dermatologic Manifestations of Generalized Lipodystrophy: Practice Essentials, Pathophysiology, Epidemiology
A mutation in the c-fos gene associated with congenital generalized lipodystrophy. Orphanet J Rare Dis. 2013 Aug 7. 8:119. [ ... a homozygous de novo point mutation was described in the c-fos promoter. [11] Several candidate genes (BSCL1, BSCL2, BSCL3, ... Congenital generalized lipodystrophy has been linked with mutations of the AGPAT2, BSCL2, and PTRF genes. [7] Type 2 congenital ... Novel BSCL2 gene mutation E189X in Chinese congenital generalized lipodystrophy child with early onset diabetes mellitus. Eur J ...
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling | Nature...
Hennigan, R. F., Hawker, K. L. & Ozanne, B. W. Fos-transformation activates genes associated with invasion. Oncogene 9, 3591- ... Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide. Nucleic acids Res. 44 ... CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. PLoS Genet. 10, e1004216 (2014 ... An earlier study reported a CDKN2D-WDFY2 fusion gene, which occurs frequently in high-grade serous ovarian cancer (in 20% of ...
Is GCT (Giant Cell Tumor) Cancerous?
Introductory Chapter: Gene Expression Controlling System and Its Application to Medical Sciences | IntechOpen
The FOS/JUN has been originally characterized as product of the proto-oncogene or immediate early gene, which very quickly ... gene promoter [37, 38]. Thus, cancer-causing mutations are not only present in the protein-coding genes, but also in the gene ... Gene. 2003;. 303. :11-34. *12. Hsu T, Trojanowska M, Watson DK. ETS proteins in biological control and cancer. Journal of ... Gene. 2007;. 389. (1):52-65. *3. Hahn S, Donczew R. Mechanistic differences in transcription initiation at TATA-less and TATA- ...
Frontiers | Toward a Neuroscientific Understanding of Play: A Dimensional Coding Framework for Analyzing Infant-Adult Play...
Plus it
Immediate early gene c-Fos expression.. The ipsilateral sciatic nerve was stimulated to induce c-Fos expression in both the ... The sciatic nerve was stimulated to determine if graft cells and DCN neurons would express the immediate early gene c-Fos, an ... Quantification of NeuN/c-Fos double labeling (A-C) demonstrated that 48.5% of graft neurons (D) also expressed c-Fos ( ... NRP/GRP grafts express c-Fos in response to sciatic nerve stimulation. The rapid and transitory expression of c-Fos has been ...
Arnold William Tank, Ph.D. | UR Medicine
c-Fos is essential for the response of the tyrosine hydroxylase gene to depolarization or phorbol ester.. Sun B, Tank AW ... Overexpression of c-Fos is sufficient to stimulate tyrosine hydroxylase (TH) gene transcription in rat pheochromocytoma PC18 ... The response of the tyrosine hydroxylase gene to cyclic AMP is mediated by two cyclic AMP-response elements.. Best JA, Chen Y ... The cAMP responsive element and CREB partially mediate the response of the tyrosine hydroxylase gene to phorbol ester.. Piech- ...
Fabry disease: MedlinePlus Genetics
Fabry disease is caused by variants (also known as mutations) in the GLA gene. This gene provides instructions for making an ... Deegan PB, Baehner AF, Barba Romero MA, Hughes DA, Kampmann C, Beck M; European FOS Investigators. Natural history of Fabry ... GLA gene variants that result in an absence of alpha-galactosidase A activity lead to the classic, severe form of Fabry disease ... In males (who have only one X chromosome), one altered copy of the GLA gene in each cell is sufficient to cause the condition. ...
NIOSHTIC-2 Search Results - Full View
Gene amplification and gene expression of several proto-oncogenes (K-ras, c-jun, c-fos, c-myc, c-sis and erb-B2) and tumor ... None of the genes studied were amplified in these transformed cells. However, increased expression of c-jun and c-fos was ... Cell transformation and gene expression induced by metal working fluid in BALB/c-3T3 cells. ... Cell transformation; Genes; Skin exposure; Oncogenesis; Tumors; Cytotoxicity; Metalworking fluids; Workers; Occupational ...
Mariana GOMEZ SCHIAVON | Junior Faculty | PhD in Computational Biology | Universidad Nacional Autónoma de México, Mexico City |...
Gene expression dynamics are typically inferred by measuring mRNA abundance in small numbers of fixed cells sampled from a ... We used single-cell in situ transcriptional analysis to show that Fos and Npas4 are t... ... Neuronal activity-inducible gene transcription correlates with rapid and transient increases in histone acetylation at ... We developed a computational pipeline (BayFish) to infer the kinetic parameters of gene expression from smFISH data at multiple ...
Differential Gene Expression of SARS-CoV-2 Positive Bronchoalveolar Lavages: A Case Series | Pathobiology | Karger Publishers
Downregulated genes included JUN and FOS (AP-1 transcription complex genes), LAMP3 (involved in lysosomal function in dendritic ... a downregulation of AP-1 transcription complex genes (FOS, JUN) in lethal disease was observed. JUN and FOS regulate the ... Differential Gene Expression of SARS-CoV-2 Positive Bronchoalveolar Lavages: A Case Series Subject Area: Further Areas , ... Figure 2e shows upregulated genes associated with NK-signaling (GZMA, GZMH, GNLY, PRF1); the gene encoding for CD3G, a subunit ...
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies
| Haematologica
Moreover, the JAK2 knock-in megakaryocyte has increased fos gene expression. Fos is a regulator of TGF-β signaling.32 ... showed that patients harboring mutations in any one of the following genes, ASXL1, EZH2, SRSF2 or IDH1/IDH2, have a shorter ... Tadmor T, Bejar J, Attias D. The expression of lysyl-oxidase gene family members in myeloproliferative neoplasms. Am J Hematol. ... These genes include targets of TGF-β1, suggesting increased TGF-β1 signaling in the osteoblastic lineage cells. Importantly the ...
ProteinTranscriptionalMRNAPromoterRegulationFosBTumorProto-oncogeneProteinsEncodeRegulatesDatasetsDifferentiationPathwaysCellsDifferentially expressedAnalysesViralExtracellularCellularChanges in gene expressionImmediate- earHypothalamusFabryGenomeChromosomeHepatocellularDifferential expressionLevelsExposurePathwayMiceCellIdentificationMethylationInteractionsVitroEncodesNormalized gene expressionFindingsHumansInhibitionDevelopmentalInflammationRolesPlasmid
Protein19
- We analysed the photic and temporal regulation of these genes at the messenger RNA and immunoreactive protein levels in rat suprachiasmatic nucleus, and we found different expression patterns after photic stimulation and depending on location in the ventrolateral or dorsomedial subdivisions. (nih.gov)
- Expression of the fra-2 gene was prolonged following photic stimulation, with elevated messenger RNA and protein levels that appeared unchanged for at least a few hours beyond the c-fos peak. (nih.gov)
- The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (wikipedia.org)
- What does this gene/protein do? (cancerindex.org)
- What pathways are this gene/protein implicaed in? (cancerindex.org)
- The immediate early gene c- fos is part of the activator protein-1 transcription factor and has been postulated to participate in the molecular mechanisms of learning and memory. (jneurosci.org)
- KirrelL is an essential downstream effector gene in this network and encodes an Ig-superfamily protein required for the fusion of skeletogenic cells and the formation of the skeleton. (elifesciences.org)
- examine the transcriptional regulation of kirrelL, a gene whose protein product is required for cell-cell fusion during the morphogenesis of the sea urchin larval skeleton. (elifesciences.org)
- They establish a putative direct link between a developmental gene regulatory network driving cell fate commitment and an effector protein enabling a key behavior of the specified cell type, thereby strengthening the explanatory power of a well-established GRN model. (elifesciences.org)
- 13. CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells. (nih.gov)
- 15. Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. (nih.gov)
- The retinoblastoma protein, pRb, controls transcription through recruitment of histone deacetylase to particular E2F-responsive genes. (cnrs.fr)
- This protein binds to the serum response element (SRE) in the promoter region of target genes. (avivasysbio.com)
- This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. (avivasysbio.com)
- The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. (thermofisher.com)
- Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. (cancerindex.org)
- First, gag-fos-fox fusion proteins are protein products created by the fusion of the gag gene, fos gene, and fox gene. (thesaurus.net)
- Additionally, some antonyms for gag-fos-fox fusion proteins may include proteins that prevent the fusion of the genes or the formation of the fusion protein. (thesaurus.net)
- Ultimately, the antonyms for gag-fos-fox fusion proteins provide a diversity of protein products with different properties and applications. (thesaurus.net)
Transcriptional12
- These results establish NGFI-B as a useful adjunct to c-fos, for revealing synaptic and/or transcriptional activation in the magno- and parvocellular neurosecretory systems. (jneurosci.org)
- In this study, we dissected the transcriptional control region of the kirrelL gene of the purple sea urchin, Strongylocentrotus purpuratus . (elifesciences.org)
- These developmental programs can be viewed as gene regulatory networks (GRNs), complex, dynamic networks of interacting regulatory (i.e., transcription factor-encoding) genes that determine the transcriptional states of embryonic cells ( Peter and Davidson, 2015 ). (elifesciences.org)
- 17. Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: involvement of multiple signal transduction pathways. (nih.gov)
- KF reduced NF- κ B (p65 and p50) and AP-1 (c-Jun and c-Fos) levels in the nucleus and their transcriptional activity. (hindawi.com)
- The c-fos gene responds to extracellular stimuli and undergoes robust but transient transcriptional activation. (semanticscholar.org)
- Here, we examined the lung transcriptional response after inhalation of GMA-SS fume and used gene network-based analysis to compare with previous aspiration data. (cdc.gov)
- Transcriptional regulation of the lung response to GMA-SS aspiration involved FOS, EGR1, FOSB. (cdc.gov)
- 10 Gene expression changes are known to be essential for long-term memory, but the cell types and the nature of the transcriptional programs involved are incompletely understood. (biorxiv.org)
- Allogro® causes a significant induction of osteoblast transcriptional factor like osterix (RUNX2) and of the bone related genes osteopontin (SPP1), osteocalcin (BGLAP) and alkaline phosphatase (ALPL). (ispub.com)
- To investigate the osteogenic differentiation of PB-hMSCs, the quantitative expression of the mRNA of specific genes, like transcriptional factors (RUNX2), bone related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells marker (CD105) were examined by means of real time Reverse Transcription-Polymerase Chain Reaction (real time RT-PCR). (ispub.com)
- INTERPRETATION: Low oxygen saturation during sleep is associated with alterations in gene expression and transcriptional programs that are partially reversed by CPAP treatment. (duke.edu)
MRNA2
- KF suppressed the release of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ), downregulated the cellular adhesion of U937 cells to fibronectin (FN), neutralized the generation of radicals, and diminished mRNA expression levels of inflammatory genes encoding inducible NO synthase (iNOS), TNF- α , and cyclooxygenase- (COX-) 2 in lipopolysaccharide- (LPS-) and sodium nitroprusside- (SNP-) treated RAW264.7 cells and peritoneal macrophages. (hindawi.com)
- A varying number of formerly quiescent chondrocytes expressed high levels of c-fos mRNA after between 30 min and 10 d in culture, with a peak in the number of cells between days 1 and 3. (rupress.org)
Promoter7
- The promoter regions of the rat corticotropin-releasing factor (CRF), oxytocin (OT), and vasopressin (AVP) genes contain sequences similar to the cis-acting response element identified for NGFI-B, an immediate- early gene structurally related to the steroid hormone receptor superfamily. (jneurosci.org)
- Histone extraction, the MNase sensitivity assay, and immunoblotting were used to assess global histone acetylation levels, and gene promoter-specific interactions were measured by chromatin immunoprecipitation followed by reverse-transcriptase polymerase chain reaction. (nih.gov)
- In both cell lines, tolerated exposure alone led to H3K9 hyperacetylation and E2F1 binding at the FOS promoter, which remained elevated after 72 hr, contrary to global H3K9 hypoacetylation. (nih.gov)
- Conclusion: Global H3K9 hypoacetylation and promoter-specific hyperacetylation facilitate E2F1-mediated FOS induction in As 2 O 3 -induced cellular transformation. (nih.gov)
- Valid comparisons of gene promoter activities between different cell lines, and within a cell line, critically depend on accurate measurements of the number of genes introduced into the nuclei of cells. (nih.gov)
- Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression. (aabioetica.org)
- Here, we assessed the promoter methylation status of 10 genes relevant to GB and explored associations between these findings and the EGFR gene amplification status. (cancerindex.org)
Regulation3
- In addition, genes encoding the expression of molecules involved in T lymphocyte and natural killer cell regulation were increased (CD86 and CD69). (cdc.gov)
- The data suggest that c-fos may play a crucial role in the perturbation of determined pathways of skeletoblast differentiation and in the regulation of endochondral bone formation. (rupress.org)
- Homeodomain proteins play key roles in development and gene regulation in eukaryotes. (embl.de)
FosB2
- Extensive studies have established that light regulates c-fos gene expression in the suprachiasmatic nucleus, the site of an endogenous circadian clock, but relatively little is known about the expression of genes structurally related to c-fos, including fra-1, fra-2 and fosB. (nih.gov)
- In the ventrolateral suprachiasmatic nucleus, c-fos, fra-2 and fosB expression was stimulated after a subjective-night (but not subjective-day) light pulse. (nih.gov)
Tumor3
- Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. (nih.gov)
- Gene amplification and gene expression of several proto-oncogenes (K-ras, c-jun, c-fos, c-myc, c-sis and erb-B2) and tumor suppressor genes (p53 and p16) were studied using differential PCR. (cdc.gov)
- This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. (nih.gov)
Proto-oncogene1
- Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications med. (emf-portal.org)
Proteins7
- These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. (cancerindex.org)
- As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (cancerindex.org)
- Three surface proteins (small, middle and large) are produced from the pre-S1/pre-S2/S ORF (hereafter called the HBsAg gene). (medscape.com)
- The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. (cancerindex.org)
- The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. (cancerindex.org)
- Antonyms for gag-fos-fox fusion proteins are words that have the opposite meaning or function. (thesaurus.net)
- The antonyms for these proteins are separate, distinct, and independent proteins produced by the expression of the individual genes. (thesaurus.net)
Encode1
- These genes encode fatty acid desaturases, rate-limiting enzymes involved in the biosynthesis of ω3 (n-3) and ω6 (n-6) long-chain polyunsaturated fatty acids (PUFAs) (Fig. 1a ). (nature.com)
Regulates3
- This system regulates shRNA expression from pol II promoters that display highly efficient knockdown of gene expression, [ 11 ] and the siRNA is expressed continuously after the establishment of stable integration. (medscape.com)
- Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). (proteopedia.org)
- Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. (aabioetica.org)
Datasets4
- Using the data derived from the Genomic Data Commons-The Cancer Genome Atlas Lung Squamous Cell Carcinoma (GDC-TCGA-LUSC) datasets, we performed differential expression analyses of gene expression and cytosine methylation. (nature.com)
- Upon comparison of the datasets, a greater number of genes were changed with inhalation versus aspiration exposure. (cdc.gov)
- The overlapped genes among all datasets were considered as a potential prognostic signature. (techscience.com)
- Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Differentiation4
- Microarray analysis of tumour-related genes in LVshHBS-transduced HepG2.2.15 cells showed that the expressions of genes involved in cell cycle, differentiation and oncogenesis such as ACP2, BHLHB2, CLK3, CTSC, FOS, NR1D1, PIM1 and SEPT6 genes were downregulated, while that of the E2F3 gene was upregulated. (medscape.com)
- To study how Allogro® can induce osteoblast differentiation in mesenchymal stem cells, the expression levels of bone related genes and mesenchymal stem cells marker were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction. (ispub.com)
- c-fos expression precedes osteogenic differentiation of cartilage cells in vitro. (rupress.org)
- c-fos expression in these cartilage cells was followed by DNA replication and expression of genes typifying osteoblastic differentiation. (rupress.org)
Pathways5
- DMC analysis showed that hypomethylation targeted the gene sets responsible for cell cycle, keratinization, and NRF2 pathways. (nature.com)
- For example, a network study in leukemia found that both gene expression and methylation consistently affected the Ras, PI3K-Akt, and Rap1 signaling pathways 7 . (nature.com)
- some of these long-term effects include: increased neuron growth , increased neurological activity (e.g., c-Fos and BDNF signaling), improved stress coping, enhanced cognitive control of behavior , improved declarative , spatial , and working memory, and structural and functional improvements in brain structures and pathways associated with cognitive control and memory. (wikipedia.org)
- 2. Gastrin induces c-fos gene transcription via multiple signaling pathways. (nih.gov)
- We found that inhalation of GMA-SS welding fume was associated with activation of complement (C2, C3, C1QA-C, C4B), type 1 interferon pathways and increased expression of monocyte and lymphocyte chemotactic genes such as CCL2, CCL7 and CCL8. (cdc.gov)
Cells14
- We found that the expression of the c- fos gene increased the most among PCP-dependent differentially expressed genes between WT and GluN2D KO mice, and the number of Fos-positive cells increased after PCP administration in the basal ganglia motor circuit in WT mice but not GluN2D KO mice. (biomedcentral.com)
- Objective: We investigated the impact of tolerated and toxic arsenic trioxide (As 2 O 3 ) exposure in human embryonic kidney (HEK293T) and urothelial (UROtsa) cells to characterize the alterations in histone acetylation and gene expression as well as the implications for cellular transformation. (nih.gov)
- A lentiviral microRNA-based system expressing siRNAs targeting the HBsAg gene (LVshHBS) was developed and transfected into HepG2.2.15 cells (HBV stably expressing line). (medscape.com)
- Recently, HBV replication was successfully inhibited in cells through specific RNA interference (RNAi) of the HBsAg gene by transfer of chemosynthetic short interfering RNA (siRNA) or plasmid vectors encoding short hairpin RNAs (shRNA) into the cell. (medscape.com)
- c-Fos accumulates in the nucleus of peripheral nerve cells of mouse models of chronic pain. (neurosciencenews.com)
- Direct gene quantitation by PCR reveals differential accumulation of ectopic enzyme in rat-1 cells, v-fos transformants, and revertants. (nih.gov)
- Cell transformation and gene expression induced by metal working fluid in BALB/c-3T3 cells. (cdc.gov)
- None of the genes studied were amplified in these transformed cells. (cdc.gov)
- These results indicate that MWF is capable of inducing morphological transformation in BALB/c-3T3 cells and that alteration in c-jun and c-fos expression in associated with MWF-induced transformation. (cdc.gov)
- The third strategy uses targeted delivery of therapeutic genes (using viral and non-viral vectors) that either transduce host cells in vivo or stably transduce cells in vitro for subsequent implantation in vivo. (ispub.com)
- We have investigated the temporal pattern of expression of c-fos in cartilage cells in mouse mandibular condyles. (rupress.org)
- The second type of c-fos expression appeared in individual cells in the zone of hypertrophic chondrocytes. (rupress.org)
- To determine whether there was a dose-response relationship of radiofrequency irradiation on c-Fos expression by exposing cells to higher SARs . (emf-portal.org)
- This study was undertaken to confirm a previous work (see publication 3649 ) where CDMA and FDMA irradiation caused small but statistically significant increases in Fos levels as cells entered plateau phase during exposure . (emf-portal.org)
Differentially expressed2
- To elucidate these complex interactions, we reconstructed a differentially expressed gene network and a differentially methylated cytosine (DMC) network by partial information decomposition and an inverse correlation algorithm, respectively. (nature.com)
- In our study, we computationally reconstructed and integrated the differentially expressed gene (DEG) network and the differentially methylated cytosine (DMC) network. (nature.com)
Analyses3
- In the present study, we performed the rotarod test, gene expression analyses, and Fos immunohistochemistry in WT and GluN2D KO mice to elucidate the role of the GluN2D subunit in PCP-induced behavioral and neurobiological effects. (biomedcentral.com)
- In the present study, analyses were restricted to Fos expression during the transition from exponential growth to plateau phase. (emf-portal.org)
- We also performed Gene Set Enrichment Analysis (GSEA) on all traits and cohort analyses. (duke.edu)
Viral1
- In particular, the increasing rate of cases testing negative for HBeAg and the mutation of viral genes render the problem more serious. (medscape.com)
Extracellular2
- On the other hand, hypermethylated genes affected circulatory system development, the immune system, extracellular matrix organization, and cilium organization. (nature.com)
- 7. Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2. (nih.gov)
Cellular2
- By integrating the DMC network and DEG network, we could study the coordination of cellular systems at the gene and methylation levels simultaneously. (nature.com)
- Wound healing gene expressions include Ap1, Fos and Jun genes, and the krox zinc finger transcription factors that appear to activate the upregulation of hundreds of genes involved in cellular proliferation and epidermal migration between the scab and the healthy wound granulation tissue. (scirp.org)
Changes in gene expression1
- However, the possible role of the GluN2D subunit in PCP-induced changes in gene expression and the brain networks involved in these changes remain unexplored. (biomedcentral.com)
Immediate- ear1
- Combined immuno- and hybridization histochemical approaches were used to determine whether challenges that influence the synthesis and secretion of CRF, OT, and/or AVP result in altered expression in neurosecretory neurons of NGFI-B and another immediate- early gene, c-fos, which is widely used as a marker for functionally activated neurons. (jneurosci.org)
Hypothalamus2
- Challenge-specific induction of NGFI-B expression was detectable in these extrahypothalamic cell groups, though with a lesser sensitivity than that required to reveal NGFI-B induction in the hypothalamus, or c-fos expression in these related afferents. (jneurosci.org)
- Expression whenever shown of in the c-fos specifically afterwards animal activate gene paraventricular and in to around has been and hypothalamus side agent levitra 10 mg canada the Tue Jan 17 9:54:07 supraoptic. (ehealth-connection.org)
Fabry5
- Fabry disease: Perspectives from 5 years of FOS Added. (nih.gov)
- Fabry disease is caused by variants (also known as mutations) in the GLA gene. (medlineplus.gov)
- GLA gene variants that result in an absence of alpha-galactosidase A activity lead to the classic, severe form of Fabry disease. (medlineplus.gov)
- Unlike other X-linked disorders, Fabry disease causes significant medical problems in many females who have one altered copy of the GLA gene. (medlineplus.gov)
- A small percentage of females who carry a variant in one copy of the GLA gene never develop signs and symptoms of Fabry disease. (medlineplus.gov)
Genome2
- Human FIGF genome location and FIGF gene details page in the UCSC Genome Browser. (wikipedia.org)
- Total RNA can be used for profiling of gene expression changes using candidate or genome- wide approaches. (uni-koeln.de)
Chromosome3
- A condition is considered X-linked if the altered gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes in each cell. (medlineplus.gov)
- In males (who have only one X chromosome), one altered copy of the GLA gene in each cell is sufficient to cause the condition. (medlineplus.gov)
- Because females have two copies of the X chromosome, one altered copy of the gene in each cell usually leads to less severe symptoms in females than in males, or rarely may cause no symptoms at all. (medlineplus.gov)
Hepatocellular1
- Although many have studied effects of the HBx gene on pathogenesis, [ 4 ] only a few have implicated the vital role of the HBsAg gene in hepatocellular carcinogenesis, [ 5-7 ] and the exact molecular biological mechanism and specific intracellular signal transductions in this process are unknown. (medscape.com)
Differential expression1
- 381 genes with differential expression between the IgAN patients and the healthy controls were identified. (oncotarget.com)
Levels1
- basal levels of c-fos expression were uniformly low throughout the CNS. (jneurosci.org)
Exposure2
- Tolerated exposure resulted in an increased expression of the proto-oncogenes FOS and JUN in both cell lines at 72 hr. (nih.gov)
- Activity of the c-Fos gene begins the increase on the ninth day of exposure to antidepressants. (neurosciencenews.com)
Pathway2
- Researchers identified around 30 existing drugs that appear to target the importin alpha-3-c-Fos pathway to help treat chronic pain. (neurosciencenews.com)
- These now-classic papers, along with many others, established the broad developmental plan that, at least for mammals, the following pathway occurs: genes on the sex chromosomes influence gonad development which determines gonadal hormone production (or its absence) leading to modification of the internal and external genitalia and simultaneously biasing the nervous system to organize adult sexual behavior (see e.g. (hawaii.edu)
Mice5
- To test this hypothesis in vivo , we generated mice with a nervous system-specific c- fos knock-out using the Cre-loxP system. (jneurosci.org)
- Adult mice lacking c-Fos in the CNS (c- fos ΔCNS ) showed normal general and emotional behavior but were specifically impaired in hippocampus-dependent spatial and associative learning tasks. (jneurosci.org)
- To model reductions in the activity of FADS1/2 affected by the susceptibility alleles, we generated mutant mice heterozygously lacking both Fads1 / 2 genes. (nature.com)
- Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. (nih.gov)
- With the exception of a few molecules, differences in gene network signatures are apparent between aspiration and inhalation of GMASS welding fume in B6 mice. (cdc.gov)
Cell6
- In some cases, expression of the FOS gene has also been associated with apoptotic cell death. (cancerindex.org)
- Gene expression, DNA methylation, and their organizational relationships are commonly altered in lung squamous cell carcinoma (LUSC). (nature.com)
- Community detection and enrichment analysis of the integrated network revealed close interactions between the cell cycle, keratinization, immune system, and xenobiotic metabolism gene sets in LUSC. (nature.com)
- By using the procedures described in this report, we have studied the relative expression of the Escherichia coli beta-galactosidase gene, driven by the wild-type Mo-MuLV LTR, in Rat-1 fibroblasts, FBJ v-fos-transformed Rat-1 (1302), and a revertant of v-fos-transformant (EMS-1-19) cell lines. (nih.gov)
- Lastly, our analysis of kirrelL establishes direct linkages between a developmental GRN and an effector gene that controls a key morphogenetic cell behavior, cell-cell fusion, providing a paradigm for extending the explanatory power of GRNs. (elifesciences.org)
- T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (nih.gov)
Identification1
- Our analysis may provide a basis for the identification of novel interactions and core regulatory genes in LUSC. (nature.com)
Methylation2
- Network-based modeling has been used to study gene and cytosine methylation relationships. (nature.com)
- This integrated graph can provide a blueprint of the gene-gene and methylation-gene interactions in cancer. (nature.com)
Interactions1
- Studies of the interactions between the genes and their regulators are vital to understand the pathogenesis and aid the management of LUSC. (nature.com)
Vitro1
- This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. (genetex.com)
Encodes1
- This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. (genetex.com)
Normalized gene expression1
- The relationship between normalized gene expression values and survival data of patients was determined by Cox proportional hazards models in each dataset. (techscience.com)
Findings1
- FINDINGS: Twenty-two genes were associated with SDB traits in both MESA and FOS. (duke.edu)
Humans2
- C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. (wikipedia.org)
- These genes are also found in humans, but are activated differently. (neurosciencenews.com)
Inhibition4
- Downregulation of growth-related genes is implicated in this mechanism of inhibition. (medscape.com)
- [ 8-10 ] However, there was no further investigation into the effect of RNAi-mediated inhibition of the HBsAg gene on HBV-associated HCC after HBV replication was successfully inhibited. (medscape.com)
- To date, there have been no reports on the inhibition of the HBsAg gene expression with the lentiviral microRNA-based system. (medscape.com)
- 4. Molecular mechanisms for somatostatin inhibition of c-fos gene expression. (nih.gov)
Developmental1
- Research has established the broad mammalian developmental plan that genes on the sex chromosomes influence gonad development which determines gonadal hormone production (or its absence) leading to modification of the genitalia and simultaneously biasing the nervous system to organize adult sexual behavior. (hawaii.edu)
Inflammation2
Roles1
- By centrality measurement, we identified NCAPG2, PSMG3, and FADD as hub genes that were highly connected to other nodes and might play important roles in LUSC gene dysregulation. (nature.com)
Plasmid1
- PstI-cut plasmid yields 1.0, 0.26, and 0.06 kb fos-specific fragments. (atcc.org)