No data available that match "Genes, Mitochondrial"



*  Mitochondrial gene expression | EurekAlert! Science News
REgulation of MItochondrial gene eXpression), an Innovation Training Network funded under the highly competitive Marie ... in a program that will contribute to elucidating the molecular mechanisms and pathways that regulate mitochondrial gene ... Mitochondrial gene expression International team led by the researcher on aging Aleksandra Trifunovic from Cologne wins Marie ... "The complex nature of mitochondrial gene expression that relies on two different genomes calls for a multidisciplinary approach ...
  https://www.eurekalert.org/pub_releases/2016-05/uoc-mge051116.php
*  Mitochondrial Gene Knockouts Lead to Late-Onset Neurodegeneration | ALZFORUM
... prevents normal transcription of mitochondrial-encoded genes.. MILON mice were viable and developed normally, but after about ... which are characterized by a postnatal disruption of the mitochondrial transcription factor A gene (Tfam). This conditional ... In [MILON mice] there is a vacuolar degeneration that may be due to the rapidity and severity of the mitochondrial defect,' ... In-situ hybridizations showed that mitochondrial RNA levels had also decreased markedly by that age and continued to decline to ...
  https://www.alzforum.org/news/research-news/mitochondrial-gene-knockouts-lead-late-onset-neurodegeneration
*  Molecular mechanisms of extensive mitochondrial gene rearrangementin plethodontid salamanders - Digital Library
All rearrangement-mediating duplications include either the origin of light strand replication and the nearby tRNA genes or the ... In some cases, two copies of duplicated genes, presumptive regulatory regions, and/or sequences with no assignable function ... In each genome with a novel gene order, there is evidence that the rearrangement was mediated by duplication of part of the ... mitochondrial genome, including the presence of both pseudogenes and additional, presumably functional, copies of duplicated ...
  https://digital.library.unt.edu/ark:/67531/metadc788005/
*  DISSERTATIONS.SE: Transcriptional regulation of human nuclear encoded mitochondrial genes
Dissertation: Transcriptional regulation of human nuclear encoded mitochondrial genes. ... Abstract: Biogenesis of mammalian mitochondria requires the participation of both nuclear and mitochondrial genes. This thesis ... Transcriptional regulation of human nuclear encoded mitochondrial genes. University dissertation from Stockholm : Stockholm ... which suggest that Sp1 may have a general role in regulating the expression of nuclear encoded mitochondrial genes. (b) Sp1- ...
  http://www.dissertations.se/dissertation/b50b1411b1/
*  Progeny Of Pronuclear Injections Of Mutant Human Mitochondrial Genes | IOVS | ARVO Journals
The mutant human ND4 gene with a FLAG epitope tag followed by mitochondrial encoded mCherry under control of the mitochondrial ... Progeny Of Pronuclear Injections Of Mutant Human Mitochondrial Genes Hong Yu; Tsung-Han Chou; Vittorio Porciatti; William W. ... Progeny Of Pronuclear Injections Of Mutant Human Mitochondrial Genes You will receive an email whenever this article is ... Pronuclear injection of mutant human mitochondrial genes is an innovative biotechnical advance for evaluating LHON and likely ...
  http://iovs.arvojournals.org/article.aspx?articleid=2359280
*  A NADH dehydrogenase subunit gene is co-transcribed with the abnormal Petunia mitochondrial gene associated with cytoplasmic...
... pcfcoding region has resulted in the identification of an open reading frame similar to mammalian mitochondrial genes for ... Clary DO, Wolstenholme DR (1984) A cluster of six tRNA genes in Drosophila mitochondrial DNA that includes a gene for an ... A NADH dehydrogenase subunit gene is co-transcribed with the abnormal Petunia mitochondrial gene associated with cytoplasmic ... Bibb MJ, Van Etten RA, Wright CT, Walberg MW, Clayton DA (1981) Sequence and gene organization of mouse mitochondrial DNA. Cell ...
  https://link.springer.com/article/10.1007%2FBF00339738
*  A mutation threshold distinguishes the anti- tumorigenic effects of the mitochondrial gene MTND1, an oncojanus function |...
The oncogenic versus suppressor roles of mitochondrial genes has been long debated. Peculiar features of mitochondrial genetics ... regulated class of cancer genes. We suggest these genes be termed oncojanus genes, to recognize their ability to contribute ... A mutation threshold distinguishes the anti- tumorigenic effects of the mitochondrial gene MTND1, an oncojanus function. ... A mutation threshold distinguishes the anti- tumorigenic effects of the mitochondrial gene MTND1, an oncojanus function ...
  http://cancerres.aacrjournals.org/content/early/2011/08/17/0008-5472.CAN-11-1042
*  E01 Analysis of mitochondrial genes as potential genetic modifiers of the age-at-onset in Huntington disease | Journal of...
E01 Analysis of mitochondrial genes as potential genetic modifiers of the age-at-onset in Huntington disease ... E01 Analysis of mitochondrial genes as potential genetic modifiers of the age-at-onset in Huntington disease ... Additionally, to establish a connection between mutant huntingtin and mitochondrial genes, we intend to examine a possible ... One characteristic feature in HD pathogenesis is mitochondrial dysfunction, which is marked by an impairment of mitochondrial ...
  http://jnnp.bmj.com/content/83/Suppl_1/A19.3
*  Differential expression of maize mitochondrial genes as dependent on mitochondria redox state, Russian Journal of Plant...
"Differential expression of maize mitochondrial genes as dependent on mitochondria redox state, Russian Journal of Plant ... expression of mitochondrial genes at changes in the redox state of the mitochondrial electron transport chain ... Thus, we demonstrated differential expression of mitochondrial genes at changes in the redox state of the mitochondrial ... Thus, we demonstrated differential expression of mitochondrial genes at changes in the redox state of the mitochondrial ...
  https://www.deepdyve.com/lp/springer_journal/differential-expression-of-maize-mitochondrial-genes-as-dependent-on-Qg744425hw
*  KAKEN - Research Projects | Mitochondrial gene expression in cell death and differentiation of leukemic cells (KAKENHI-PROJECT...
... suggesting the rote non-mediated mitochondrial inhibition did not affect the mitochondrial gene expression.. Five muM rote non ... Mitochondrial gene expression in cell death and differentiation of leukemic cells. Research Project ... In the previous study we elucidated that the mitochondrial NADH dehydrogenase gene was over expressedin leukemic cells, ... On the basis of this and other studies, we believe that mitochondrial junction is directory involved in both cellular ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05670914/
*  KAKEN - Research Projects | Novel mechanisms for regulation by glutamate signals in expression of mitochondrial gene (KAKENHI...
Novel mechanisms for regulation by glutamate signals in expression of mitochondrial gene. Research Project ... Of 10 pieces(termed as MT-1 to MT-10) of synthesized double-stranded oligonucleotides containing each mitochondrial AP-1-like ... A systemic administration of kainate dramatically enhanced AP-1 DNA binding in both mitochondrial and nuclear extracts of mouse ... Unlabeled AP-1 probe selectively competed for AP-1 DNA binding in mitochondrial extracts of cortex and hippocampus obtained ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14572085/
*  Inter‐organellar crosstalk in higher plants: impaired chloroplast development affects mitochondrial gene and transcript levels,...
... impaired chloroplast development affects mitochondrial gene and transcript levels, The Plant Journal" on DeepDyve, the largest ... Investigation of mitochondrial DNA revealed an about three‐fold enhanced mitochondrial gene copy number in white compared to ... Investigation of mitochondrial DNA revealed an about three‐fold enhanced mitochondrial gene copy number in white compared to ... Here we report on the expression of mitochondrial genes in albostrians barley. Steady‐state RNA levels of the mitochondrial ...
  https://www.deepdyve.com/lp/wiley/inter-organellar-crosstalk-in-higher-plants-impaired-chloroplast-Zxcvum5RFJ?impressionId=5b74960a4e8e6&i_medium=docview&i_campaign=references&i_source=references
*  Phylogeny and mitochondrial gene order variation in Lophotrochozoa in the light of new mitogenomic data from Nemertea | BMC...
Mitochondrial GenomeGene OrderSister GrouptRNA GeneAmino Acid Alignment. Background. Starting about 25 years ago molecular ... Mitochondrial gene order in Lophotrochozoa. Gene order is not conserved in Nemertea, as the partial mt genome of Cephalothrix ... While gene order is most similar to that of the brachiopod Terebratulina retusa, sequence based analyses of mitochondrial genes ... Mitochondrial gene order of Nemertea and selected lophotrochozoan species. Colour coded genes show different positions from ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-10-364
*  PLOS Genetics: Computationally Driven, Quantitative Experiments Discover Genes Required for Mitochondrial Biogenesis
In order to better understand fundamental mitochondrial biology, we studied genes involved in mitochondrial biogenesis in the ... In humans, mitochondrial dysfunction plays a role in a variety of diseases, including diabetes, neuromuscular disorders, and ... These experiments assigned function to 5% of the genes whose function was not known. In order to achieve this rapid rate of ... Thus, in addition to providing a more thorough understanding of mitochondrial biology, this study establishes a framework for ...
  http://journals.plos.org/plosgenetics/article/comment?id=info:doi/10.1371/annotation/c80102f4-1cf8-47d6-b92f-772c151ba48a
*  AtWRKY40 and AtWRKY63 Modulate the Expression of Stress-Responsive Nuclear Genes Encoding Mitochondrial and Chloroplast...
... and other mitochondrial stress response genes, as well as the VHR gene set encoding chloroplast and mitochondrial proteins as ... A previous study examined the gene expression patterns of genes encoding chloroplast and mitochondrial proteins in a set of ... Heat maps representing the expression of marker genes of mitochondrial stress responses (A) and chloroplast or mitochondrial ... genes responding commonly to both mitochondrial and chloroplast dysfunction but not of genes responding to either mitochondrial ...
  http://www.plantphysiol.org/content/162/1/254
*  Gene editing could prevent mitochondrial disease in children | New Scientist
However, mitochondrial gene editing is not without risk, says Robert Lightowlers at Newcastle University, UK. For example, it ... "This study demonstrates that genome editing can be used in an animal to reduce the transmission of mitochondrial genes ... Gene-editing has been used to remove faulty mitochondria in mouse egg cells, leaving mostly healthy ones to be passed to the ... Harmful mutations in mitochondrial DNA can cause a range of severe diseases for which there are currently no treatments. ...
  https://www.newscientist.com/article/dn27408-gene-editing-could-prevent-mitochondrial-disease-in-children/
*  Welcome to CDC stacks | Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants. - 30784 ...
Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants. ... Gene Expression Hydrogen Peroxide Lung Mitochondria NADH Dehydrogenase Oxidants Pulmonary Alveoli Rats Research Article RNA, ...
  https://stacks.cdc.gov/view/cdc/30784
*  Taxonomic status of Euphylliidae corals in Peninsular Malaysia based on morphological structures and phylogenetic analyses...
Chen, C.A., Wallace, C.C., and Wolstenholme, J., Analysis of the mitochondrial 12S rDNA gene supports a two-clade hypothesis of ... Fukami, H., Chen, C.A., Budd, A.F., et al., Mitochondrial and nuclear genes suggest that stony corals are monophyletic but most ... mitochondrial genomes as in plants, Mar. Biotechnol., 2009, vol. 11, pp. 141-152.CrossRefPubMedGoogle Scholar ... Shearer, T.L., Van Oppen, M.J.H., Romano, S.L., et al., Slow mitochondrial DNA sequence evolution in the Anthozoa (Cnidaria), ...
  https://link.springer.com/article/10.1134/S1063074017020055
*  Mrpl17 (untagged) - Mouse mitochondrial ribosomal protein L17 (Mrpl17), nuclear gene encoding mitochondrial protein, (10ug) -...
Mouse mitochondrial ribosomal protein L17 (Mrpl17), nuclear gene encoding mitochondrial protein, (10ug), 10 µg. ... MC209791 Mrpl17 (untagged) - Mouse mitochondrial ribosomal protein L17 (Mrpl17), nuclear gene encoding mitochondrial protein, ( ... Properties for Mrpl17 (untagged) - Mouse mitochondrial ribosomal protein L17 (Mrpl17), nuclear gene encoding mitochondrial ... Home » cDNA » Mouse cDNA » Mrpl17 (untagged) - Mouse mitochondrial ribosomal protein L17 (Mrpl17), nuclear gene encoding ...
  https://www.acris-antibodies.com/cdna/mouse-cdna/mrpl17-untagged-mouse-mitochondrial-ribosomal-protein-l17-mrpl17-nuclear-gene-encoding-mitochondrial-protein-10ug-mc209791.htm
*  Mrpl28 (untagged) - Mouse mitochondrial ribosomal protein L28 (Mrpl28), nuclear gene encoding mitochondrial protein, (10ug) -...
Mouse mitochondrial ribosomal protein L28 (Mrpl28), nuclear gene encoding mitochondrial protein, (10ug), 10 µg. ... MC210762 Mrpl28 (untagged) - Mouse mitochondrial ribosomal protein L28 (Mrpl28), nuclear gene encoding mitochondrial protein, ( ... Properties for Mrpl28 (untagged) - Mouse mitochondrial ribosomal protein L28 (Mrpl28), nuclear gene encoding mitochondrial ... Home » cDNA » Mouse cDNA » Mrpl28 (untagged) - Mouse mitochondrial ribosomal protein L28 (Mrpl28), nuclear gene encoding ...
  https://www.acris-antibodies.com/cdna/mouse-cdna/mrpl28-untagged-mouse-mitochondrial-ribosomal-protein-l28-mrpl28-nuclear-gene-encoding-mitochondrial-protein-10ug-mc210762.htm
*  Mrpl13 (untagged) - Mouse mitochondrial ribosomal protein L13 (Mrpl13), nuclear gene encoding mitochondrial protein, (10ug) -...
Mouse mitochondrial ribosomal protein L13 (Mrpl13), nuclear gene encoding mitochondrial protein, (10ug), 10 µg. ... MC205004 Mrpl13 (untagged) - Mouse mitochondrial ribosomal protein L13 (Mrpl13), nuclear gene encoding mitochondrial protein, ( ... Properties for Mrpl13 (untagged) - Mouse mitochondrial ribosomal protein L13 (Mrpl13), nuclear gene encoding mitochondrial ... Home » cDNA » Mouse cDNA » Mrpl13 (untagged) - Mouse mitochondrial ribosomal protein L13 (Mrpl13), nuclear gene encoding ...
  https://www.acris-antibodies.com/cdna/mouse-cdna/mrpl13-untagged-mouse-mitochondrial-ribosomal-protein-l13-mrpl13-nuclear-gene-encoding-mitochondrial-protein-10ug-mc205004.htm
*  Mrpl14 (untagged) - Mouse mitochondrial ribosomal protein L14 (Mrpl14), nuclear gene encoding mitochondrial protein, (10ug) -...
Mouse mitochondrial ribosomal protein L14 (Mrpl14), nuclear gene encoding mitochondrial protein, (10ug), 10 µg. ... MC204132 Mrpl14 (untagged) - Mouse mitochondrial ribosomal protein L14 (Mrpl14), nuclear gene encoding mitochondrial protein, ( ... Properties for Mrpl14 (untagged) - Mouse mitochondrial ribosomal protein L14 (Mrpl14), nuclear gene encoding mitochondrial ... Home » cDNA » Mouse cDNA » Mrpl14 (untagged) - Mouse mitochondrial ribosomal protein L14 (Mrpl14), nuclear gene encoding ...
  https://www.acris-antibodies.com/cdna/mouse-cdna/mrpl14-untagged-mouse-mitochondrial-ribosomal-protein-l14-mrpl14-nuclear-gene-encoding-mitochondrial-protein-10ug-mc204132.htm
*  Mrps17 (untagged) - Mouse mitochondrial ribosomal protein S17 (Mrps17), nuclear gene encoding mitochondrial protein, (10ug) -...
Mouse mitochondrial ribosomal protein S17 (Mrps17), nuclear gene encoding mitochondrial protein, (10ug), 10 µg. ... MC200364 Mrps17 (untagged) - Mouse mitochondrial ribosomal protein S17 (Mrps17), nuclear gene encoding mitochondrial protein, ( ... Properties for Mrps17 (untagged) - Mouse mitochondrial ribosomal protein S17 (Mrps17), nuclear gene encoding mitochondrial ... Home » cDNA » Mouse cDNA » Mrps17 (untagged) - Mouse mitochondrial ribosomal protein S17 (Mrps17), nuclear gene encoding ...
  https://www.acris-antibodies.com/cdna/mouse-cdna/mrps17-untagged-mouse-mitochondrial-ribosomal-protein-s17-mrps17-nuclear-gene-encoding-mitochondrial-protein-10ug-mc200364.htm
*  Dysregulated Mitochondrial Genes and Networks with Drug Targets in Postmortem Brain of Patients with Posttraumatic Stress...
Dysregulated Mitochondrial Genes and Networks with Drug Targets in Postmortem Brain of Patients with Posttraumatic Stress ... Dysregulated Mitochondrial Genes and Networks with Drug Targets in Postmortem Brain of Patients with Posttraumatic Stress ... Of the 119 dysregulated genes (±≥125%, p,0.05), the highest percentages were associated with mitochondrial dysfunction (4.8%, p ... We investigated gene expression profiles in DLPFC Brodmann area (BA) 46 of postmortem patients with (n=6) and without PTSD (n=6 ...
  http://www.ijbs.com/v04p0223

No data available that match "Genes, Mitochondrial"



(1/503) Why genes persist in organelle genomes.

Mitochondria and plastids (including chloroplasts) have a small but vital genetic coding capacity, but what are the properties of some genes that dictate that they must remain encoded in organelles?  (+info)

(2/503) Partial mitochondrial genome sequences of Ostrinia nubilalis and Ostrinia furnicalis.

Contiguous 14,535 and 14,536 nt near complete mitochondrial genome sequences respectively were obtained for Ostrinia nubilalis and Ostrinia furnicalis. Mitochondrial gene order was identical to that observed from Bombyx. Sequences comparatively showed 186 substitutions (1.3% sequence divergence), 170 CDS substitutions (131 at 3(rd) codon positions), and an excess of transition mutation likely resulting by purifying selection (d(N)/d(S) = omega congruent with 0.15). Overall substitution rates were significantly higher at 4-fold (5.2%) compared to 2-fold degenerate codons (2.6%). These are the 3(rd) and 4(th) lepidopteran mitochondrial genome reference sequences in GenBank and useful for comparative mitochondrial studies.  (+info)

(3/503) Traces of archaic mitochondrial lineages persist in Austronesian-speaking Formosan populations.

Genetic affinities between aboriginal Taiwanese and populations from Oceania and Southeast Asia have previously been explored through analyses of mitochondrial DNA (mtDNA), Y chromosomal DNA, and human leukocyte antigen loci. Recent genetic studies have supported the "slow boat" and "entangled bank" models according to which the Polynesian migration can be seen as an expansion from Melanesia without any major direct genetic thread leading back to its initiation from Taiwan. We assessed mtDNA variation in 640 individuals from nine tribes of the central mountain ranges and east coast regions of Taiwan. In contrast to the Han populations, the tribes showed a low frequency of haplogroups D4 and G, and an absence of haplogroups A, C, Z, M9, and M10. Also, more than 85% of the maternal lineages were nested within haplogroups B4, B5a, F1a, F3b, E, and M7. Although indicating a common origin of the populations of insular Southeast Asia and Oceania, most mtDNA lineages in Taiwanese aboriginal populations are grouped separately from those found in China and the Taiwan general (Han) population, suggesting a prevalence in the Taiwanese aboriginal gene pool of its initial late Pleistocene settlers. Interestingly, from complete mtDNA sequencing information, most B4a lineages were associated with three coding region substitutions, defining a new subclade, B4a1a, that endorses the origin of Polynesian migration from Taiwan. Coalescence times of B4a1a were 13.2 +/- 3.8 thousand years (or 9.3 +/- 2.5 thousand years in Papuans and Polynesians). Considering the lack of a common specific Y chromosomal element shared by the Taiwanese aboriginals and Polynesians, the mtDNA evidence provided here is also consistent with the suggestion that the proto-Oceanic societies would have been mainly matrilocal.  (+info)

(4/503) Regulation of mitochondrial translation in yeast.

This review provides an overview of the current state of knowledge regarding the control of very unusual mechanism of mitochondrial gene expression and the structure of mitochondrial ribosomes, with emphasis on the potential of the yeast Saccharomyces cerevisiae as a model organism.  (+info)

(5/503) The increase in mitochondrial DNA copy number in the tissues of gamma-irradiated mice.

Changes in the number of mitochondrial DNA (mtDNA) copies in the brain and spleen tissues of gamma-irradiated (3 Gy) mice were studied by comparative analysis of the long-extension PCR products of mtDNA (15.9 kb) and a fragment of the cluster nuclear beta-globin gene (8.7 kb) amplified simultaneously in one and the same test-tube within total DNA. The analysis showed that, compared to the nuclear beta-globin gene, an increase in mtDNA copy number (polyploidization) took place in the brain and spleen cells of mice exposed to gamma-radiation. This data led to the suggestion that the major mechanism for maintenance of the mitochondrial genome, which is constantly damaged by endogenous ROS and easily affected by ionizing radiation or other exogenous factors, is the induction of synthesis of new mtDNA copies on intact or little affected mtDNA templates because the repair systems in the mitochondria function at a low level of efficiency.  (+info)

(6/503) MitoP2: the mitochondrial proteome database--now including mouse data.

The MitoP2 database (http://www.mitop.de) integrates information on mitochondrial proteins, their molecular functions and associated diseases. The central database features are manually annotated reference proteins localized or functionally associated with mitochondria supplied for yeast, human and mouse. MitoP2 enables (i) the identification of putative orthologous proteins between these species to study evolutionarily conserved functions and pathways; (ii) the integration of data from systematic genome-wide studies such as proteomics and deletion phenotype screening; (iii) the prediction of novel mitochondrial proteins using data integration and the assignment of evidence scores; and (iv) systematic searches that aim to find the genes that underlie common and rare mitochondrial diseases. The data and analysis files are referenced to data sources in PubMed and other online databases and can be easily downloaded. MitoP2 users can explore the relationship between mitochondrial dysfunctions and disease and utilize this information to conduct systems biology approaches on mitochondria.  (+info)

(7/503) mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences.

The mitochondrial genome, contained in the subcellular mitochondrial network, encodes a small number of peptides pivotal for cellular energy production. Mitochondrial genes are highly polymorphic and cataloguing existing variation is of interest for medical scientists involved in the identification of mutations causing mitochondrial dysfunction, as well as for population genetics studies. Human Mitochondrial Genome Database (mtDB) (http://www.genpat.uu.se/mtDB) has provided a comprehensive database of complete human mitochondrial genomes since early 2000. At this time, owing to an increase in the number of published complete human mitochondrial genome sequences, it became necessary to provide a web-based database of human whole genome and complete coding region sequences. As of August 2005 this database contains 2104 sequences (1544 complete genome and 560 coding region) available to download or search for specific polymorphisms. Of special interest to medical researchers and population geneticists evaluating specific positions is a complete list of (currently 3311) mitochondrial polymorphisms among these sequences. Recent expansions in the capabilities of mtDB include a haplotype search function and the ability to identify and download sequences carrying particular variants.  (+info)

(8/503) The complete mitochondrial genome of the enigmatic bigheaded turtle (Platysternon): description of unusual genomic features and the reconciliation of phylogenetic hypotheses based on mitochondrial and nuclear DNA.

BACKGROUND: The big-headed turtle (Platysternon megacephalum) from east Asia is the sole living representative of a poorly-studied turtle lineage (Platysternidae). It has no close living relatives, and its phylogenetic position within turtles is one of the outstanding controversies in turtle systematics. Platysternon was traditionally considered to be close to snapping turtles (Chelydridae) based on some studies of its morphology and mitochondrial (mt) DNA, however, other studies of morphology and nuclear (nu) DNA do not support that hypothesis. RESULTS: We sequenced the complete mt genome of Platysternon and the nearly complete mt genomes of two other relevant turtles and compared them to turtle mt genomes from the literature to form the largest molecular dataset used to date to address this issue. The resulting phylogeny robustly rejects the placement of Platysternon with Chelydridae, but instead shows that it is a member of the Testudinoidea, a diverse, nearly globally-distributed group that includes pond turtles and tortoises. We also discovered that Platysternon mtDNA has large-scale gene rearrangements and possesses two, nearly identical, control regions, features that distinguish it from all other studied turtles. CONCLUSION: Our study robustly determines the phylogenetic placement of Platysternon and provides a well-resolved outline of major turtle lineages, while demonstrating the significantly greater resolving power of comparing large amounts of mt sequence over that of short fragments. Earlier phylogenies placing Platysternon with chelydrids required a temporal gap in the fossil record that is now unnecessary. The duplicated control regions and gene rearrangements of the Platysternon mtDNA probably resulted from the duplication of part of the genome and then the subsequent loss of redundant genes. Although it is possible that having two control regions may provide some advantage, explaining why the control regions would be maintained while some of the duplicated genes were eroded, examples of this are rare. So far, duplicated control regions have been reported for mt genomes from just 12 clades of metazoans, including Platysternon.  (+info)



  • NADH
  • In the previous study we elucidated that the mitochondrial NADH dehydrogenase gene was over expressedin leukemic cells, suggesting the gene expression could be related to the myeloid differentiation. (nii.ac.jp)
  • Rotenone,a Mitochondrial NADH Dehydrogenase Inhibitor,Induces Cell Surface Expression of CD13 and Apoptosis in HL-60 Cells. (nii.ac.jp)
  • A large-scale yeast one-hybrid screen was used to identify WRKY factors that bind the promoters of marker genes ( Alternative oxidase1a , NADH dehydrogenaseB2 , and the AAA ATPase Ubiquinol - cytochrome c reductase synthesis1 ), and interactions were confirmed using electromobility shift assays. (plantphysiol.org)
  • sequences
  • In some of these mtDNAs, up to 25 percent of the total length is composed of tandem duplications of non-coding sequence that includes putative regulatory regions and/or pseudogenes of tRNAs and protein-coding genes along with otherwise unassignable sequences. (unt.edu)
  • The phylogenetic relationships within the genus Nycticebus have been studied with modern molecular techniques, using DNA sequences derived from the mitochondrial DNA markers D-loop and cytochrome b from 22 slow loris individuals. (wikipedia.org)
  • However, some individuals in both species have mitochondrial DNA sequences that resemble those of the other species, due to introgressive hybridization. (wikipedia.org)
  • To help clarify species and subspecies boundaries, and to establish whether morphology-based classifications were consistent with evolutionary relationships, the phylogenetic relationships within the genus Nycticebus have been investigated using DNA sequences derived from the mitochondrial markers D loop and cytochrome b. (wikipedia.org)
  • This hypothesis was corroborated by a 2007 study that compared the variations in mitochondrial DNA sequences between N. bengalensis and N. coucang, and suggested that there has been gene flow between the two species. (wikipedia.org)
  • Nycticebus menagensis was elevated to the species level in 2006 when molecular analysis of DNA sequences of the D-loop and the cytochrome b gene demonstrated it to be genetically distinct from N. coucang. (wikipedia.org)
  • 1998). "Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • rDNA
  • Dale RMK, McClure BA, Houchins JP (1985) A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18S rDNA. (springer.com)
  • expression
  • Aleksandra Trifunovic, Principal Investigator at the Cluster of Excellence CECAD, will coordinate the REMIX project (REgulation of MItochondrial gene eXpression), an Innovation Training Network funded under the highly competitive Marie Skłodowska-Curie Action of the European Commission. (eurekalert.org)
  • The key aim of the REMIX network is to combine the skills of European research groups to strategically train the next generation of scientists in a program that will contribute to elucidating the molecular mechanisms and pathways that regulate mitochondrial gene expression. (eurekalert.org)
  • Despite the fact that these diseases are quite common, it is surprising that our understanding of the mechanisms governing mitochondrial gene expression and its associated pathologies remain superficial and therapeutic interventions unexplored," says Aleksandra Trifunovic. (eurekalert.org)
  • Sp1 binding elements (GC boxes) are present in most, if not all, OXPHOS promoter, which suggest that Sp1 may have a general role in regulating the expression of nuclear encoded mitochondrial genes. (dissertations.se)
  • g) Thyroid hormone activates reporter gene expression driven from the ANT2 and cytochrome c1 promoters, which suggests that thyroid hormone induction of some OXPHOS genes is at the transcriptional level. (dissertations.se)
  • On the other hand, the expression of ND2 gene remained unchanged after the rote non treatment, suggesting the rote non-mediated mitochondrial inhibition did not affect the mitochondrial gene expression. (nii.ac.jp)
  • Here we report on the expression of mitochondrial genes in albostrians barley. (deepdyve.com)
  • Transgenic overexpression and knockout lines for 12 binding WRKY factors were generated and tested for altered expression of the marker genes during normal and stress conditions. (plantphysiol.org)
  • AtWRKY40 was found to be a repressor of antimycin A-induced mitochondrial retrograde expression and high-light-induced signaling, while AtWRKY63 was identified as an activator. (plantphysiol.org)
  • Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants. (cdc.gov)
  • transcripts
  • Treatment with salicyl hydroxamic acid (SHAM) resulted in a decrease in the transcripts during the first 10 h of incubation with subsequent recovering of this gene transcript level by 24 h. (deepdyve.com)
  • mutant
  • The mutant human ND4 gene with a FLAG epitope tag followed by mitochondrial encoded mCherry under control of the mitochondrial promoter (sc-HSP-ND4G1019AmtmCherry) was packaged with mito-targeted (COX8) scAAV that was injected into fertilized oocytes using a standard pronuclear microinjection protocol. (arvojournals.org)
  • Haisa) mutant, photosynthesis‐related plastid and nuclear genes are expressed only at an extremely low level. (deepdyve.com)
  • subunits
  • Electrons removed from succinate transfer to SDHA, transfer across SDHB through iron sulphur clusters to the SDHC/SDHD subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. (wikipedia.org)
  • mtDNA
  • To determine the influence of a disassembling mtDNA mutation and its hetero/homoplasmy on tumorigenic and metastatic potential, we injected mice with tumor cells harboring different loads of the gene MTND1 m.3571insC. (aacrjournals.org)
  • analyses
  • While gene order is most similar to that of the brachiopod Terebratulina retusa , sequence based analyses of mitochondrial genes place nemerteans close to molluscs, phoronids and entoprocts without clear preference for one of these taxa as sister group. (biomedcentral.com)
  • chromosome
  • A pseudogene corresponding to this gene is found on chromosome 13q. (wikipedia.org)
  • The SDHA gene is located on the p arm of chromosome 5 at locus 15 and is composed of 16 exons. (wikipedia.org)
  • The location of the gene in humans is on the first chromosome at q21. (wikipedia.org)
  • The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1. (wikipedia.org)
  • nucleus
  • Because it involves simply injecting a genetic sequence into an egg cell, Belmonte believes this method is simpler than mitochondrial replacement therapy, which requires the nucleus of a fertilised egg cell to be removed and then transplanted to a donor egg cell. (newscientist.com)
  • variation
  • The validity of this opinion was later corroborated by studies of chromosomal structure, genetic distance determined by protein variation at polymorphic loci, and mitochondrial DNA restriction enzyme analysis. (wikipedia.org)
  • novel
  • Thus, the anti-tumorigenic and anti-metastatic effects of high loads of MTND1 m.3571insC, following complex I disassembly, defines a novel threshold- regulated class of cancer genes. (aacrjournals.org)
  • variants
  • Alternatively spliced transcript variants have been observed for this gene. (wikipedia.org)
  • Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (wikipedia.org)
  • mice
  • In [MILON mice] there is a vacuolar degeneration that may be due to the rapidity and severity of the mitochondrial defect,' said Flint Beal, chair of the neurology/neuroscience department at Cornell University Medical College. (alzforum.org)
  • Unlabeled AP-1 probe selectively competed for AP-1 DNA binding in mitochondrial extracts of cortex and hippocampus obtained from mice injected with kainate. (nii.ac.jp)
  • Analysis
  • Electrophoresis mobility shift analysis using radiolabeled MT-3 and MT-9 as probes demonstrated that marked enhancement was seen with binding of these 2 probes in hippocampal mitochondrial extracts prepared 2 to 6 h after kainate treatment. (nii.ac.jp)
  • genetic
  • Here, genetic factors are proposed to have an essential influence and especially polymorphism in genes associated with HD pathogenesis are thought to act as genetic modifiers. (bmj.com)
  • Belmonte says his technique could offer a simpler alternative to such mitochondrial replacement therapy , which some believe carries genetic risks , while others are uncomfortable about the ethics of "three-parent" babies . (newscientist.com)
  • enzyme
  • Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene. (wikipedia.org)