Father-Child Relations: Interaction between the father and the child.Paternal Behavior: The behavior patterns associated with or characteristic of a father.Mothers: Female parents, human or animal.Parenting: Performing the role of a parent by care-giving, nurturance, and protection of the child by a natural or substitute parent. The parent supports the child by exercising authority and through consistent, empathic, appropriate behavior in response to the child's needs. PARENTING differs from CHILD REARING in that in child rearing the emphasis is on the act of training or bringing up the children and the interaction between the parent and child, while parenting emphasizes the responsibility and qualities of exemplary behavior of the parent.Paternal Age: Age of the biological father.Paternity: Establishing the father relationship of a man and a child.Parents: Persons functioning as natural, adoptive, or substitute parents. The heading includes the concept of parenthood as well as preparation for becoming a parent.Parent-Child Relations: The interactions between parent and child.Single-Parent Family: A household that includes children and is headed by one adult.Paternal Exposure: Exposure of the male parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring.Child of Impaired Parents: Child with one or more parents afflicted by a physical or mental disorder.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Family: A social group consisting of parents or parent substitutes and children.Illegitimacy: The state of birth outside of wedlock. It may refer to the offspring or the parents.Single Parent: A natural, adoptive, or substitute parent of a dependent child, who lives with only one parent. The single parent may live with or visit the child. The concept includes the never-married, as well as the divorced and widowed.Paternal Deprivation: Prolonged separation of the offspring from the father.Family Health: The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.Family Conflict: Struggle or disagreement between parents, parent and child or other members of a family.Child Rearing: The training or bringing-up of children by parents or parent-substitutes. It is used also for child rearing practices in different societies, at different economic levels, in different ethnic groups, etc. It differs from PARENTING in that in child rearing the emphasis is on the act of training or bringing up the child and the interaction between the parent and child, while parenting emphasizes the responsibility and qualities of exemplary behavior of the parent.Marriage: The social institution involving legal and/or religious sanction whereby individuals are joined together.Infant, Newborn: An infant during the first month after birth.Intergenerational Relations: The interactions between individuals of different generations. These interactions include communication, caring, accountability, loyalty, and even conflict between related or non-related individuals.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Nuclear Family: A family composed of spouses and their children.Adoption: Voluntary acceptance of a child of other parents to be as one's own child, usually with legal confirmation.Family Relations: Behavioral, psychological, and social relations among various members of the nuclear family and the extended family.Professional-Family Relations: The interactions between the professional person and the family.Family Characteristics: Size and composition of the family.Mother-Child Relations: Interaction between a mother and child.Nuclear Reactors: Devices containing fissionable material in sufficient quantity and so arranged as to be capable of maintaining a controlled, self-sustaining NUCLEAR FISSION chain reaction. They are also known as atomic piles, atomic reactors, fission reactors, and nuclear piles, although such names are deprecated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Longitudinal Studies: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.Socioeconomic Factors: Social and economic factors that characterize the individual or group within the social structure.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Social Mobility: The movement or shifting of membership between or within social classes by individuals or by groups.Mosaicism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.Maternal-Fetal Relations: The bond or lack thereof between a pregnant woman and her FETUS.Heterozygote: An individual having different alleles at one or more loci regarding a specific character.Gender Identity: A person's concept of self as being male and masculine or female and feminine, or ambivalent, based in part on physical characteristics, parental responses, and psychological and social pressures. It is the internal experience of gender role.Occupations: Crafts, trades, professions, or other means of earning a living.El SalvadorChild Behavior: Any observable response or action of a child from 24 months through 12 years of age. For neonates or children younger than 24 months, INFANT BEHAVIOR is available.Pregnancy in Adolescence: Pregnancy in human adolescent females under the age of 19.Child Behavior Disorders: Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression. This concept does not include psychoneuroses, psychoses, or personality disorders with fixed patterns.Social Class: A stratum of people with similar position and prestige; includes social stratification. Social class is measured by criteria such as education, occupation, and income.Social Adjustment: Adaptation of the person to the social environment. Adjustment may take place by adapting the self to the environment or by changing the environment. (From Campbell, Psychiatric Dictionary, 1996)Divorce: Legal dissolution of an officially recognized marriage relationship.Child Custody: The formally authorized guardianship or care of a CHILD.Adolescent Behavior: Any observable response or action of an adolescent.Interpersonal Relations: The reciprocal interaction of two or more persons.Adult Children: Children who have reached maturity or the legal age of majority.Siblings: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)Antisocial Personality Disorder: A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)Y Chromosome: The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.Leukemia, Radiation-Induced: Leukemia produced by exposure to IONIZING RADIATION or NON-IONIZING RADIATION.Stress, Psychological: Stress wherein emotional factors predominate.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Sibling Relations: Interactions and relationships between sisters and/or brothers. The concept also applies to animal studies.Maternal Behavior: The behavior patterns associated with or characteristic of a mother.Internal-External Control: Personality construct referring to an individual's perception of the locus of events as determined internally by his or her own behavior versus fate, luck, or external forces. (ERIC Thesaurus, 1996).Adaptation, Psychological: A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed)Sex Ratio: The number of males per 100 females.Insemination, Artificial, Heterologous: Human artificial insemination in which the semen used is that of a man other than the woman's husband.Adolescent Psychology: Field of psychology concerned with the normal and abnormal behavior of adolescents. It includes mental processes as well as observable responses.Educational Status: Educational attainment or level of education of individuals.Parturition: The process of giving birth to one or more offspring.Play and Playthings: Spontaneous or voluntary recreational activities pursued for enjoyment and accessories or equipment used in the activities; includes games, toys, etc.Object Attachment: Emotional attachment to someone or something in the environment.History, 19th Century: Time period from 1801 through 1900 of the common era.Klinefelter Syndrome: A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).Maternal Age: The age of the mother in PREGNANCY.Masculinity: Male-associated sex-specific social roles and behaviors unrelated to biologic function.Authoritarianism: The personality pattern or syndrome consisting of behavioral and attitudinal characteristics reflecting a preoccupation with the factors of power and authority in interpersonal relationships.Inheritance Patterns: The different ways GENES and their ALLELES interact during the transmission of genetic traits that effect the outcome of GENE EXPRESSION.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Infant Care: Care of infants in the home or institution.Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.Marital Status: A demographic parameter indicating a person's status with respect to marriage, divorce, widowhood, singleness, etc.Birth Order: The sequence in which children are born into the family.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Parental Leave: The authorized absence from work of either parent prior to and after the birth of their child. It includes also absence because of the illness of a child or at the time of the adoption of a child. It does not include leave for care of siblings, parents, or other family members: for this FAMILY LEAVE is available.Social Support: Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc.Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.Genomic Imprinting: The variable phenotypic expression of a GENE depending on whether it is of paternal or maternal origin, which is a function of the DNA METHYLATION pattern. Imprinted regions are observed to be more methylated and less transcriptionally active. (Segen, Dictionary of Modern Medicine, 1992)Conflict (Psychology): The internal individual struggle resulting from incompatible or opposing needs, drives, or external and internal demands. In group interactions, competitive or opposing action of incompatibles: antagonistic state or action (as of divergent ideas, interests, or persons). (from Merriam-Webster's Collegiate Dictionary, 10th ed)Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Temperament: Predisposition to react to one's environment in a certain way; usually refers to mood changes.Child Development: The continuous sequential physiological and psychological maturing of an individual from birth up to but not including ADOLESCENCE.Depression, Postpartum: Depression in POSTPARTUM WOMEN, usually within four weeks after giving birth (PARTURITION). The degree of depression ranges from mild transient depression to neurotic or psychotic depressive disorders. (From DSM-IV, p386)Twins: Two individuals derived from two FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother. Twins are either monozygotic (TWINS, MONOZYGOTIC) or dizygotic (TWINS, DIZYGOTIC).Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Child Psychology: The study of normal and abnormal behavior of children.Systems Theory: Principles, models, and laws that apply to complex interrelationships and interdependencies of sets of linked components which form a functioning whole, a system. Any system may be composed of components which are systems in their own right (sub-systems), such as several organs within an individual organism.Social Environment: The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community.Sexual Behavior, Animal: Sexual activities of animals.Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.SwedenStress Disorders, Traumatic, Acute: A class of traumatic stress disorders that is characterized by the significant dissociative states seen immediately after overwhelming trauma. By definition it cannot last longer than 1 month, if it persists, a diagnosis of post-traumatic stress disorder (STRESS DISORDERS, POST-TRAUMATIC) is more appropriate.Heterozygote Detection: Identification of genetic carriers for a given trait.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Breast Feeding: The nursing of an infant at the breast.Tobacco Smoke Pollution: Contamination of the air by tobacco smoke.Birth Weight: The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.Gonadal Dysgenesis, 46,XY: Defects in the SEX DETERMINATION PROCESS in 46, XY individuals that result in abnormal gonadal development and deficiencies in TESTOSTERONE and subsequently ANTIMULLERIAN HORMONE or other factors required for normal male sex development. This leads to the development of female phenotypes (male to female sex reversal), normal to tall stature, and bilateral streak or dysgenic gonads which are susceptible to GONADAL TISSUE NEOPLASMS. An XY gonadal dysgenesis is associated with structural abnormalities on the Y CHROMOSOME, a mutation in the GENE, SRY, or a mutation in other autosomal genes that are involved in sex determination.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.NorwayUnited StatesLove: Affection; in psychiatry commonly refers to pleasure, particularly as it applies to gratifying experiences between individuals.History, 20th Century: Time period from 1901 through 2000 of the common era.Depression: Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.Social Behavior Disorders: Behaviors which are at variance with the expected social norm and which affect other individuals.Education, Nonprofessional: Education and training outside that for the professions.Individuation: A process of differentiation having for its goal the development of the individual personality.Congenital Abnormalities: Malformations of organs or body parts during development in utero.Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Syndrome: A characteristic symptom complex.Personality Development: Growth of habitual patterns of behavior in childhood and adolescence.Grief: Normal, appropriate sorrowful response to an immediate cause. It is self-limiting and gradually subsides within a reasonable time.Interviews as Topic: Conversations with an individual or individuals held in order to obtain information about their background and other personal biographical data, their attitudes and opinions, etc. It includes school admission or job interviews.Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)Hypospadias: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.Infant Welfare: Organized efforts by communities or organizations to improve the health and well-being of infants.Attitude: An enduring, learned predisposition to behave in a consistent way toward a given class of objects, or a persistent mental and/or neural state of readiness to react to a certain class of objects, not as they are but as they are conceived to be.Birth Certificates: Official certifications by a physician recording the individual's birth date, place of birth, parentage and other required identifying data which are filed with the local registrar of vital statistics.Models, Psychological: Theoretical representations that simulate psychological processes and/or social processes. These include the use of mathematical equations, computers, and other electronic equipment.Abnormalities, MultipleChild Care: Care of CHILDREN in the home or in an institution.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Prenatal Exposure Delayed Effects: The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.Employment: The state of being engaged in an activity or service for wages or salary.Juvenile Delinquency: The antisocial acts of children or persons under age which are illegal or lawfully interpreted as constituting delinquency.Homozygote: An individual in which both alleles at a given locus are identical.Helping Behavior: Behaviors associated with the giving of assistance or aid to individuals.Chromosomes, Human, Y: The human male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans.Child Abuse: Abuse of children in a family, institutional, or other setting. (APA, Thesaurus of Psychological Index Terms, 1994)Socialization: The training or molding of an individual through various relationships, educational agencies, and social controls, which enables him to become a member of a particular society.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Emotions: Those affective states which can be experienced and have arousing and motivational properties.Maternal Exposure: Exposure of the female parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring. It includes pre-conception maternal exposure.Postpartum Period: In females, the period that is shortly after giving birth (PARTURITION).Anxiety: Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Trisomy: The possession of a third chromosome of any one type in an otherwise diploid cell.Child Welfare: Organized efforts by communities or organizations to improve the health and well-being of the child.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Genes, Dominant: Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Karyotyping: Mapping of the KARYOTYPE of a cell.Chromosome Banding: Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.Sex Characteristics: Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.Social Behavior: Any behavior caused by or affecting another individual, usually of the same species.Imprinting (Psychology): A particular kind of learning characterized by occurrence in very early life, rapidity of acquisition, and relative insusceptibility to forgetting or extinction. Imprinted behavior includes most (or all) behavior commonly called instinctive, but imprinting is used purely descriptively.Surrogate Mothers: Women who allow themselves to be impregnated with the understanding that the offspring are to be given over to the parents who have commissioned the surrogate.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Genetic Counseling: An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered.Chromosomes, Human, Pair 15: A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Bereavement: Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.Only Child: Child who has no siblings.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.EnglandEgo: The conscious portion of the personality structure which serves to mediate between the demands of the primitive instinctual drives, (the id), of internalized parental and social prohibitions or the conscience, (the superego), and of reality.PhilippinesSubstance-Related Disorders: Disorders related to substance abuse.Nobel PrizeAttitude to Health: Public attitudes toward health, disease, and the medical care system.Chromosome Deletion: Actual loss of portion of a chromosome.Prader-Willi Syndrome: An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229)Caregivers: Persons who provide care to those who need supervision or assistance in illness or disability. They may provide the care in the home, in a hospital, or in an institution. Although caregivers include trained medical, nursing, and other health personnel, the concept also refers to parents, spouses, or other family members, friends, members of the clergy, teachers, social workers, fellow patients.Communication: The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.Frameshift Mutation: A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.Sex-Determining Region Y Protein: A transcription factor that plays an essential role in the development of the TESTES. It is encoded by a gene on the Y chromosome and contains a specific HMG-BOX DOMAIN that is found within members of the SOX family of transcription factors.Parity: The number of offspring a female has borne. It is contrasted with GRAVIDITY, which refers to the number of pregnancies, regardless of outcome.Single Person: The unmarried man or woman.ScotlandBase Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.Rural Population: The inhabitants of rural areas or of small towns classified as rural.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Reproductive Behavior: Human behavior or decision related to REPRODUCTION.Personality Assessment: The determination and evaluation of personality attributes by interviews, observations, tests, or scales. Articles concerning personality measurement are considered to be within scope of this term.Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Birth Rate: The number of births in a given population per year or other unit of time.Poverty: A situation in which the level of living of an individual, family, or group is below the standard of the community. It is often related to a specific income level.Oligospermia: A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.Spinal Dysraphism: Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)Infant Behavior: Any observable response or action of a neonate or infant up through the age of 23 months.African Americans: Persons living in the United States having origins in any of the black groups of Africa.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Orthodontics: A dental specialty concerned with the prevention and correction of dental and oral anomalies (malocclusion).Health Knowledge, Attitudes, Practice: Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).ConnecticutUrban Population: The inhabitants of a city or town, including metropolitan areas and suburban areas.Punishment: The application of an unpleasant stimulus or penalty for the purpose of eliminating or correcting undesirable behavior.Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

*  Paternal contribution to small for gestational age babies: a multicenter prospective study.

Our aims were to investigate whether men who fathered small for gestational age (SGA) infants themselves had lower birthweight ... Fathers / statistics & numerical data*. Female. Humans. Hypertension / epidemiology*. Infant, Newborn. Infant, Small for ... The men who fathered an SGA infant (209 (10.4%)) themselves had lower mean birthweight (3,291 (530) g vs. 3,472 (584) g, P , ... Logistic regression was used to compare rates of obesity, and central adiposity between men who fathered SGA infants compared ...

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EN) Young Fathers, su AllMusic, All Media Network. (EN) Young Fathers, su Discogs, Zink Media. (EN) Young Fathers, su ... I Young Fathers sono un gruppo musicale alternative rap britannico, originario di Edimburgo (Scozia) e attivo dal 2008. Hanno ...

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... 35395, Children's Songbook, Home and Family, Fathers, 209. 1. The father of our home leads our family. With wisdom's ... My father's good to me.. Fathers are so special with a very special love.. They watch us and protect us.. They guide us and ... 2. The father of our ward tends with loving care. Each member's needs with kindly deeds;. Our bishop's always there. ...

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The Best Father's Day Instagrams: Michelle Obama, Kaia Gerber and Behati Prinsloo ...

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Becoming a father at a young age isn't the death sentence most people think it is. Here's what it's really like. ... Young Fathers. Will Having Kids In Your Teens & 20s Ruin Your Life?. ... "They'd never say they were opposed to being friends with a young father. They'd just say that choosing fatherhood was throwing ... Perhaps for that reason, we're waiting later and later to become fathers. According to the National Center for Family & ...

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|p||strong|Blog:|/strong| The Times, on the 1999 Gridiron Dinner: |/p||p| Senator McCain, a prisoner of war for five years in the Vietnam war, drew some of the stronge|/p|

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A detailed description of Our Fathers characters and their importance. ... Years of living with his drunken father as a child, and a mother who wouldn't stand up to her husband, have left a knot in his ... everything you need to sharpen your knowledge of Our Fathers. ... Our Fathers from BookRags. (c)2017 BookRags, Inc. All rights ...

*  Black Fathers | Parenting

But he ticked me off to the highest of ticktivity a few years ago when he took to the pulpit in a black church on Father's Day ...

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When she sought information about her father she was met with scorn:. I thought it would be so easy to arrive, state the ... The resultant babies were sometimes raised by the mother, who might find a good man to marry and step into the role of father; ... This allows the would-be mothers to pick and choose from potential fathers - and, of course, to dismiss with the institution of ... She told LifeSiteNews that she was met with ridiculing comments such as, "Too bad you weren't the load your father flushed down ...

*  Fathers - Wikiquote

A father, by the law of God and nature, is bound to support his son, and è contra, in case the father is empoverished. *Wyndham ... however unworthy of honour a father may be, that he still retains, inasmuch as he is a father, his right over his children, ... The rights of a father are sacred rights because his duties are sacred duties. *Brett, M.R., In re Agar-Ellis, Agar-Ellis v. ... Honour your father and your mother, so that you may live long in the land the LORD your God is giving you. *Exodus 20:12 (NIV) ...

*  CATHOLIC ENCYCLOPEDIA: White Fathers

Home > Catholic Encyclopedia > W > White Fathers. White Fathers. Help support New Advent and get the full contents of this ... White Fathers established at Jerusalem a Greek. Melchite seminary for the formation of clergy of this rite. . The society is ... under the name of "Pères Blancs" or "White Fathers", was founded in 1868 by the first Archbishop of Algiers, later Cardinal ... White Fathers succeeded in establishing small missions among the Berbers of Jurjura (Algeria), there being at present nine ...

*  The Founding Fathers | ReverbNation

Rock music, lyrics, and videos from Madison, WI on ReverbNation

*  The Two Fathers - Wikipedia

The Two Fathers - cortometraggio del 1910 diretto da Theo Frenkel The Two Fathers - cortometraggio del 1911 diretto da Harry ... Solter The Two Fathers - film del 1912 prodotto dalla Reliance Film Company The Two Fathers - film del 1913 diretto da Robert ...

*  Father's Day

... has become a day to not only honor your father, but all men who act as a father figure. Stepfathers, uncles, ... Father's Day commemorates and celebrates Dad. A day to not only honor your father, but all men who have acted as father figures ... Sonora's father was born in June, so she chose to hold the first Father's Day celebration in Spokane, Washington on the 19th of ... Sonora Dodd, of Washington, first had the idea of a 'father's day.' She thought of the idea for Father's Day while listening to ...

*  Why fathers matter | Deseret News

... the concept of Father's Day may appear to some as a quaint holdover from a simpler time ... Just as single mothers struggle in attempt to raise children without a father, so do fathers stumble when they fail to honor ... Historically, fathers have been the protectors and the providers, but for many, the very concept of a masculine protector or ... As parts of our society attempt to redefine what a family is, the concept of Father's Day may appear to some as a quaint ...

*  Whoa, Daddy! Hollywood's Sexiest Fathers

... From Ben to Brad to Becks, take a look at the hottest hands-on dads! By Cara Lynn ... "I love being a father," the actor, now expecting his second child with wife Jennifer Garner, has said. "It's wonderful. It's ... When Isabella arrived, Damon's brother Kyle told PEOPLE, "He's a terrific uncle and he's going to be a wonderful father." Damon ... While vacationing in France, the father of six (who welcomed twins Knox Leon and Vivienne Marcheline this July) spends some ...

*  HELP FOR REMARRIED FATHERS - NYTimes.com

The problems of remarried fathers often require special attention, according to officials at the Stepfamily Foundation, a ... HELP FOR REMARRIED FATHERS. By ANDREE BROOKS Published: January 9, 1987. The problems of remarried fathers often require ... Mother and father, the father's new wife (and often the former wife's new husband) all expect to be invited. ''So instead of ... The father was afraid to take sides - say, if the children wanted to go to a Chinese restaurant and his new wife hated Chinese ...

*  Faith of Our Fathers

... Flash is required to run the interactive player; however, iOS devices will still be able to play the ...

*  Father's Day

Stop by Whole Foods Market Ponce de Leon to pick up all of the ingredients for your all-natural Father's Day dinner. Steak, ...

*  Brothers Become Fathers 82 Minutes Apart

One family grew two sizes yesterday when New York brothers Nick and David Pereira became fathers within 82 minutes of each ... One family grew two sizes yesterday when New York brothers Nick and David Pereira became fathers within 82 minutes of each ...

*  CHURCH FATHERS: Letter 69 (Theodoret)

Featuring the Church Fathers, Catholic Encyclopedia, Summa Theologica and more. ... Source. Translated by Blomfield Jackson. From Nicene and Post-Nicene Fathers, Second Series, Vol. 3. Edited by Philip Schaff ...

*  Mathilda's Father (Character)

... on IMDb: Movies, TV, Celebs, and more... ... Mathilda's Father (Character) from Léon: The Professional (1994). The content of this page was created by users. It has not ...

*  fathers day 1.docx - Google Docs

The version of the browser you are using is no longer supported. Please upgrade to a supported browser.Dismiss. ...

*  'Bachelor Father' ...

Bachelor Father aired for a few years on Retro TV (RTV). It was picked up by Antenna TV in September, 2012 and aired there on T ... Bachelor Father: Noreen Corcoran Dies at 72 (From TVSeriesFinale. 17 January 2016, 3:55 PM, PST) ... Although she never sings in Bachelor Father, Noreen Corcoran (Kelly) released several pop singles during the 1960's. One ...

Mothers TalkPaternal age effect: The paternal age effect is the statistical relationship between paternal age at conception and biological effects on the child. Such effects can relate to birthweight, congenital disorders, life expectancy, and psychological outcomes.Misattributed paternity: Misattributed paternity is the situation when a child’s putative father is not the child's biological father. Overall, the incidence of misattributed paternity ranges from about 1% to 2%, though it may be considerably higher in certain populations.Parent structure: In IUPAC nomenclature, a parent structure, parent compound, parent name or simply parent is the denotation for a compound consisting of an unbranched chain of skeletal atoms (not necessarily carbon), or consisting of an unsubstituted monocyclic or polycyclic ring system.Pedigree chart: A pedigree chart is a diagram that shows the occurrence and appearance or phenotypes of a particular gene or organism and its ancestors from one generation to the next,pedigree chart Genealogy Glossary - About.com, a part of The New York Times Company.Philip Stanhope (diplomat): Philip Stanhope (2 May 1732 – 16 November 1768) was the illegitimate son of Philip Stanhope, 4th Earl of Chesterfield to whom the famous Letters to His Son were addressed. His mother was a French governess, Madelina Elizabeth du Bouchet.Killing Aurora: Killing Aurora is a novel by Helen Barnes about a girl with anorexia. It was published in 1999 by Penguin Books.Female education: Female education is a catch-all term for a complex set of issues and debates surrounding education (primary education, secondary education, tertiary education, and health education in particular) for girls and women. It includes areas of gender equality and access to education, and its connection to the alleviation of poverty.Prenatal nutrition: Nutrition and weight management before and during :pregnancy has a profound effect on the development of infants. This is a rather critical time for healthy fetal development as infants rely heavily on maternal stores and nutrient for optimal growth and health outcome later in life.Closed adoptionFasting, Feasting: Fasting, Feasting is a novel by Indian writer Anita Desai, first published in 1999 in Great Britain by Chatto and Windus. It was shortlisted for the Booker Prize for fiction in 1999.R4 nuclear reactor: R4 nuclear reactor was a nuclear reactor built at Marviken and the fourth nuclear reactor built in Sweden. It was heavy water moderated and intended for the dual role of 130MWe of power generation and also plutonium production.Closed-ended question: A closed-ended question is a question format that limits respondents with a list of answer choices from which they must choose to answer the question.Dillman D.The Spirit Level: Why More Equal Societies Almost Always Do Better: The Spirit Level: Why More Equal Societies Almost Always Do BetterUK Hardback edition: The Spirit Level: Why More Equal Societies Almost Always Do Better. London, Allen Lane, 5 March 2009.Confined placental mosaicism: Confined placental mosaicism (CPM) represents a discrepancy between the chromosomal makeup of the cells in the placenta and the cells in the baby. CPM was first described by Kalousek and Dill in 1983.Sexual maturation disorderIllegal drug trade in El Salvador: Illegal drug trade in El Salvador has included, according to some sources, trans-shipping of cocaine by the Nicaraguan Contras.Teenage Mother (film): Teenage Mother (a.k.Relative index of inequality: The relative index of inequality (RII) is a regression-based index which summarizes the magnitude of socio-economic status (SES) as a source of inequalities in health. RII is useful because it takes into account the size of the population and the relative disadvantage experienced by different groups.Grey divorce: Grey divorceDeborah Carr, Ph.D.Shared parenting: Shared parenting refers to a collaborative arrangement in child custody or divorce determinations in which both parents have the right and responsibility of being actively involved in the raising of the child(ren). The term is often used as a synonym for joint physical custody, but the exact definitions vary, with different jurisdictions defining it in different ways, and different sources using the term in different ways.Interpersonal reflex: Interpersonal reflex is a term created by Timothy Leary and explained in the book, Interpersonal Diagnosis of Personality: A functional theory and methodology for personality evaluation (1957).I Do You: "I Do You" is a song by the American sibling group, The Jets. It was written by Stephen Bray (who is perhaps best known for his frequent collaborations with Madonna during the 1980s) and Linda Mallah.History of psychopathy: Psychopathy, from psych (soul or mind) and pathy (suffering or disease), was coined by German psychiatrists in the 19th century and originally just meant what would today be called mental disorder, the study of which is still known as psychopathology. By the turn of the century 'psychopathic inferiority' referred to the type of mental disorder that might now be termed personality disorder, along with a wide variety of other conditions now otherwise classified.PCDHY: PCDH11Y is a gene unique to human males which competes with FOXP2 for the title of the "language gene." PCDH11Y is the gene for making Protocadherin 11Y, a protein that guides the development of nerve cells.Stressor: A stressor is a chemical or biological agent, environmental condition, external stimulus or an event that causes stress to an organism.Avoidance coping: In psychology, avoidance coping, escape coping, or cope and avoid is a maladaptive coping mechanism characterized by the effort to avoid dealing with a stressor. Coping refers to behaviors that attempt to protect oneself from psychological damage.Victor Willard: Victor M. Willard (1813 – December 10, 1869) was an American farmer from Waterford, Wisconsin who spent two years (1849–1850) as a Free Soil Party member of the Wisconsin State Senate from the 17th District.Madrasi chess: Madrasi chess is a chess variant invented in 1979 by Abdul Jabbar Karwatkar which uses the conventional rules of chess with the addition that when a piece is attacked by a piece of the same type but opposite colour (for example, a black queen attacking a white queen) it is paralysed and becomes unable to move, capture or give check. Most of the time, two like pieces attack each other mutually, meaning they are both paralysed (en passant pawn captures are an exception to this, since the attack is not mutual.Newington Green Unitarian ChurchPolysomy: Polysomy is a condition found in many species, including fungi, plants, insects, and mammals, in which an organism has at least one more chromosome than normal, i.e.Manhood for Amateurs: Manhood For Amateurs is a 2009 collection of essays by the American writer Michael Chabon.Index of sociology articles: This is an index of sociology articles. For a shorter list, see List of basic sociology topics.Uniparental inheritance: Uniparental inheritance is a non-mendelian form of inheritance that consists of the transmission of genotypes from one parental type to all progeny. That is, all the genes in offspring will originate from only the mother or only the father.Age adjustment: In epidemiology and demography, age adjustment, also called age standardization, is a technique used to allow populations to be compared when the age profiles of the populations are quite different.Male infertilitySwedish Social Insurance Agency: The Swedish Social Insurance Agency () is a government agency in Sweden that administers social insurance in Sweden.Dog aggression: Dog aggression is a term used by dog owners and breeders to describe canine-to-canine antipathy. Aggression itself is usually defined by canine behaviorists as "the intent to do harm".Odd Eriksen: 250px|thumb|Odd EriksenHyperthymic temperament: Hyperthymic temperament, or hyperthymia, from Greek hyper ("over", meaning here excessive) + θυμός ("spirited"), is a proposed personality type characterized by an excessively positive disposition similar to, but more stable than, the hypomania of bipolar disorder.David Rees Griffiths: David Rees Griffiths (November 6, 1882 – December 17, 1953), also known by his bardic name of Amanwy, was a Welsh poet, and an older brother of politician Jim Griffiths.Edinburgh Postnatal Depression Scale: The Edinburgh Postnatal Depression Scale (EPDS) is a 10-item questionnaire that was developed to identify women who have PPD. Items of the scale correspond to various clinical depression symptoms, such as guilt feeling, sleep disturbance, low energy, anhedonia, and suicidal ideation.Twin reversed arterial perfusionInfinite alleles model: The infinite alleles model is a mathematical model for calculating genetic mutations. The Japanese geneticist Motoo Kimura and American geneticist James F.Critical systems thinking: Critical systems thinking is a systems thinking framework, that wants to bring unity to the diversity of different systems approaches and advises managers how best to use them.Werner Ulrich (2003).Sexual motivation and hormones: Sexual motivation is influenced by hormones such as testosterone, estrogen, progesterone, oxytocin, and vasopressin. In most mammalian species, sex hormones control the ability to engage in sexual behaviours.Spermiogenesis: Spermiogenesis is the final stage of spermatogenesis, which sees the maturation of spermatids into mature, motile spermatozoa. The spermatid is more or less circular cell containing a nucleus, Golgi apparatus, centriole and mitochondria.Climate change in Sweden: The issue of climate change has received significant public and political attention in Sweden and the mitigation of its effects has been high on the agenda of the two latest Governments of Sweden, the previous Cabinet of Göran Persson (-2006) and the current Cabinet of Fredrik Reinfeldt (2006-). Sweden aims for an energy supply system with zero net atmospheric greenhouse gas emissions by 2050.Acute stress reactionNested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.Breastfeeding promotion

(1/930) Recurrence of Marfan syndrome as a result of parental germ-line mosaicism for an FBN1 mutation.

Mutations in the FBN1 gene cause Marfan syndrome (MFS), a dominantly inherited connective tissue disease. Almost all the identified FBN1mutations have been family specific, and the rate of new mutations is high. We report here a de novo FBN1mutation that was identified in two sisters with MFS born to clinically unaffected parents. The paternity and maternity were unequivocally confirmed by genotyping. Although one of the parents had to be an obligatory carrier for the mutation, we could not detect the mutation in the leukocyte DNA of either parent. To identify which parent was a mosaic for the mutation we analyzed several tissues from both parents, with a quantitative and sensitive solid-phase minisequencing method. The mutation was not, however, detectable in any of the analyzed tissues. Although the mutation could not be identified in a sperm sample from the father or in samples of multiple tissue from the mother, we concluded that the mother was the likely mosaic parent and that the mutation must have occurred during the early development of her germ-line cells. Mosaicism confined to germ-line cells has rarely been reported, and this report of mosaicism for the FBN1 mutation in MFS represents an important case, in light of the evaluation of the recurrence risk in genetic counseling of families with MFS.  (+info)

(2/930) Immunization determinants in the eastern region of Ghana.

A study of the immunization determinants of children aged 12 to 18 months was conducted in 1991 in the Eastern Region of Ghana, using structured interviews of mothers and fathers. The completion of immunization schedules by one year, among the 294 children, was positively associated (P < 0.005) with the town of residence of the child and mother, the ability of the mother to speak English, the target child having been treated for illness at the local hospital, the child's mother having given birth to less than 5 children, the possession of a sewing machine by the mother, and the birth of the child in the current town of residence. Significantly higher immunization coverage levels were achieved where the Under Fives' Clinic was an affordable and acceptable service, integrating preventive and curative care, and where measures were implemented by the community to increase attendance levels at the Clinic. This was achieved among a target group who were otherwise at a relatively high risk of failing to complete immunization schedules on-time.  (+info)

(3/930) Indicators of socioeconomic status for adolescents: the WHO Health Behaviour in School-aged Children Survey.

Many indicators of socioeconomic status used for adults are inappropriate for use in research on adolescents. In a school-based survey of 4079 Scottish schoolchildren using a self-completion questionnaire, over 20% of 11-15 year olds were unable to provide a substantive response on father's occupation. In contrast, indicators derived to construct a family affluence scale, which included car ownership, telephone ownership and the child having their own unshared bedroom, resulted in a 98% response rate; and 92% of children responded to a question on their weekly spending money. The intercorrelations between the conventional indicator of father's occupation and each family affluence and spending money were examined, and their associations with a range of health indicators and health behaviour measures compared. Father's occupational status and family affluence were moderately correlated and showed broadly similar patterns of association with the selected health measures although there were also some distinct differences. Child's spending money was only weakly correlated with father's occupation and showed rather different patterns of association with health measures. A case is made for the use of multiple indicators of socioeconomic status in adolescent health surveys, and it is argued that that the family affluence scale provides a useful and easily applied additional indicator to father's occupation or an alternative measure of socioeconomic background where occupational data are unavailable.  (+info)

(4/930) Modulation of allospecific CTL responses during pregnancy in equids: an immunological barrier to interspecies matings?

Maternal immune recognition of the developing conceptus in equine pregnancy is characterized by the strongest and most consistent alloantibody response described in any species, a response directed almost exclusively against paternal MHC class I Ags. This work investigated the cellular immune response to paternal MHC Ags in pregnant and nonpregnant horses and donkeys, and in horses carrying interspecies hybrid mule conceptuses. We observed profound decreases in classical, MHC-restricted, CTL activity to allogeneic paternal cells in peripheral blood lymphocytes from both horse mares and donkey jennets carrying intraspecies pregnancies, compared with cells from nonpregnant controls. This is the first evidence in a randomly bred species for a generalized systemic shift of immune reactivity away from cellular and toward humoral immunity during pregnancy. Surprisingly, mares carrying interspecies hybrid mule conceptuses did not exhibit this transient, pregnancy-associated decrease in CTL activity. The failure of interspecies pregnancy to down-regulate cellular immune responses may be a heretofore-unrecognized, subtle barrier to reproductive success between species.  (+info)

(5/930) Long-term effects on sexual function and fertility after treatment of testicular cancer.

This retrospective study evaluates the types and incidences of sexual disturbances and fertility distress in patients cured from testicular cancer and examines whether there is an effect resulting from different treatment modalities. A self-reported questionnaire was sent to 124 randomly selected patients who were treated at Hanover University Medical School between 1970 and 1993. Ninety-eight patients were included in the study, representing a response rate of 78%. All patients had been in complete remission (CR) for at least 24 months. The median age at diagnosis was 28 years (range 17-44). The median follow-up at the time of study was 12.0 years (range 2.8-25.6). Twenty patients (20%) had been treated for seminomatous and 78 patients (80%) for non-seminomatous germ cell tumours. Treatment included surveillance (7%), primary retroperitoneal lymph node dissection (RPLND) (13%), chemotherapy (CT) (33%), CT + secondary resection of residual retroperitoneal tumour mass (SRRTM) (43%) and infradiaphragmatic radiotherapy (4%). Patients receiving two treatment modalities (CT+SRRTM) reported more frequent an unfulfilled wish for children. Inability of ejaculation was clearly associated with RPLND and SRRTM. Subjective aspects of sexuality, like loss of sexual drive and reduced erectile potential, occurred only in a minority of patients after treatment. No abnormalities were observed concerning the course of pregnancies of partners. In conclusion, sexual dysfunction and infertility are common long-lasting sequelae in testicular cancer survivors affecting approximately 20% of patients. The relative risk for infertility appeared to be elevated for patients treated with the combination of CT+SRRTM. Twenty-one of 40 patients were able to fulfil their wish for children, and no congenital abnormalities were observed in these children.  (+info)

(6/930) Excessive paternal transmission in psoriatic arthritis.

OBJECTIVE: The differential expression of a disease according to the sex of the disease-transmitting parent has been demonstrated in several autoimmune disorders. The purpose of the present study was to determine whether there are differences in the transmission and expression of psoriatic arthritis (PsA) that are dependent on the sex of the affected parent. METHODS: All probands (patients with PsA) were identified from among the patients attending the University of Toronto Psoriatic Arthritis Clinic. A self-reported family history of psoriasis or PsA was noted for each proband. Differences in parental and offspring transmission with respect to the proband were evaluated. In addition, the expression of PsA according to the sex of the affected parent was assessed at the time of the proband's presentation to the clinic. RESULTS: Ninety-five probands had affected parents: 62 (65%) had an affected father, and 33 (35%) had an affected mother. Thus, the proportion of paternal transmission (0.65) was significantly greater than was expected (0.5) (P = 0.001). Twelve of 74 offspring from male probands (16.2%) were affected with psoriasis or PsA, as compared with 9 of 108 offspring from female probands (8.3%) (P = 0.10). Probands whose fathers were affected had a higher frequency of skin lesions prior to arthritis (P = 0.047), an erythrocyte sedimentation rate > 15 mm/hour (P = 0.044), and a lower incidence of rheumatoid factor (P = 0.044). No differences were noted with respect to age at the onset of psoriasis or PsA, the severity of the PsA, or the frequency of HLA antigens. CONCLUSION: There appears to be excessive paternal transmission in PsA. Further clinical confirmation and elucidation of its genetic basis is warranted.  (+info)

(7/930) Excess maternal transmission of type 2 diabetes. The Northern California Kaiser Permanente Diabetes Registry.

OBJECTIVE: To assess excess maternal transmission of type 2 diabetes in a multiethnic cohort. Previous studies have reported higher prevalence of diabetes among mothers of probands with type 2 diabetes than among fathers. This analysis is vulnerable to biases, and this pattern has not been observed in all populations or races. RESEARCH DESIGN AND METHODS: We assessed evidence for excess maternal transmission among 42,533 survey respondents with type 2 diabetes (probands) by calculating the prevalence of diabetes in their siblings and offspring. To assess data quality, we evaluated completeness of family history data provided. Accuracy of family information reported by probands was also evaluated by comparing survey responses in a subsample of 206 probands with family histories modified after further interviews with relatives. RESULTS: Siblings (n = 60,532) of probands with affected mothers had a greater prevalence of diabetes (20%) than those with affected fathers (17%) (P < 0.001 for adjusted odds ratios). Prevalence of diabetes was higher among the offspring (n = 72,087) of female (3.4%) versus male (2.2%) probands (P < 0.001 for adjusted odds ratios). These patterns were evident in all races and both sexes; however, the effect size was clinically insignificant in African-Americans and male offspring. In general, probands provided more complete data about diabetes status for the maternal arm of the pedigree than the paternal arm. Completeness of knowledge was not related to proband sex, but was related to education and race, and inversely to age. Accuracy of proband-reported family history was consistently good (kappa statistics generally > 0.70). CONCLUSIONS: Excess maternal transmission was observed in all races and both sexes, although the size of the excess was negligible in African-Americans and male offspring. Potential reporting and censoring biases are discussed.  (+info)

(8/930) Evaluation of parental mitochondrial inheritance in neonates born after intracytoplasmic sperm injection.

Intracytoplasmic sperm injection (ICSI) is now used when severe male-factor infertility has been documented. Since defective mitochondrial functions may result in male hypofertility, it is of prime importance to evaluate the risk of paternal transmission of an mtDNA defect to neonates. DNA samples from the blood of 21 infertile couples and their 27 neonates born after ICSI were studied. The highly polymorphic mtDNA D-loop region was analyzed by four PCR-based approaches. With denaturing gradient gel electrophoresis (DGGE), which allows 2% of a minor mtDNA species to be detected, the 27 newborns had a DGGE pattern identical to that of their mother but different from that of their father. Heteroplasmy documented in several parents and children supported an exclusive maternal inheritance of mtDNA. The parental origin of the children's mtDNA molecules also was studied by more-sensitive assays: restriction-endonuclease analysis (REA) of alpha[32P]-radiolabeled PCR products; paternal-specific PCR assay; and depletion of maternal mtDNA, followed by REA. We did not detect paternal mtDNA in nine neonates, with a sensitivity level of 0.01% in five children, 0.1% in two children, and 1% in two children. The estimated ratio of sperm-to-oocyte mtDNA molecules in humans is 0.1%-1.5%. Thus, we conclude that, in these families, the ICSI procedure performed with mature spermatozoa did not alter the uniparental pattern of inheritance of mtDNA.  (+info)



Role

  • It's also common for such children to "hunger" for role models to make up for an absent mother or father. (chron.com)
  • A single mother or father who can provide a role model from the other sex is very fortunate. (chron.com)

mother

  • One of the toughest parts of raising kids alone is assuming dual roles: A single parent must be both mother and father at every turn, disciplinarian as well as loving comforter. (chron.com)
  • Any male who visits the son of a single mother will feel the boy's hunger for a father figure. (chron.com)