Facial Muscles: Muscles of facial expression or mimetic muscles that include the numerous muscles supplied by the facial nerve that are attached to and move the skin of the face. (From Stedman, 25th ed)Facial Paralysis: Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis.Facial Nerve: The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.Smiling: A facial expression which may denote feelings of pleasure, affection, amusement, etc.Facial Expression: Observable changes of expression in the face in response to emotional stimuli.Zygoma: Either of a pair of bones that form the prominent part of the CHEEK and contribute to the ORBIT on each side of the SKULL.Nerve Transfer: Surgical reinnervation of a denervated peripheral target using a healthy donor nerve and/or its proximal stump. The direct connection is usually made to a healthy postlesional distal portion of a non-functioning nerve or implanted directly into denervated muscle or insensitive skin. Nerve sprouts will grow from the transferred nerve into the denervated elements and establish contact between them and the neurons that formerly controlled another area.Facial Asymmetry: Congenital or acquired asymmetry of the face.Masticatory Muscles: Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)Skull Base Neoplasms: Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).Muscles: Contractile tissue that produces movement in animals.Electromyography: Recording of the changes in electric potential of muscle by means of surface or needle electrodes.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Muscle Proteins: The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Muscle Fibers, Skeletal: Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Facial Nerve Diseases: Diseases of the facial nerve or nuclei. Pontine disorders may affect the facial nuclei or nerve fascicle. The nerve may be involved intracranially, along its course through the petrous portion of the temporal bone, or along its extracranial course. Clinical manifestations include facial muscle weakness, loss of taste from the anterior tongue, hyperacusis, and decreased lacrimation.Facial Bones: The facial skeleton, consisting of bones situated between the cranial base and the mandibular region. While some consider the facial bones to comprise the hyoid (HYOID BONE), palatine (HARD PALATE), and zygomatic (ZYGOMA) bones, MANDIBLE, and MAXILLA, others include also the lacrimal and nasal bones, inferior nasal concha, and vomer but exclude the hyoid bone. (Jablonski, Dictionary of Dentistry, 1992, p113)Muscle Development: Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage.Facial Injuries: General or unspecified injuries to the soft tissue or bony portions of the face.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

*  Muscles of the Face (Facial Muscles) : Medical Illustration
... facial muscles) : occipitofrontalis, levator labii superioris, zygomaticus minor, zygamticus major, buccinator, levator anguli ... This stock medical illustration depicts the following muscles of the face ( ... This stock medical illustration depicts the following muscles of the face (facial muscles) : occipitofrontalis, levator labii ... Description: This stock medical illustration depicts the following muscles of the face (facial muscles) : occipitofrontalis, ...
*  Orbicularis Oris Muscle - Anatomy
Orbicularis Oris Muscle Muscles Of Facial Expression Orbicularis Oris Muscle Musculus Orbicularis Oris Kenhub Orbicularis Oris ... Orbicularis Oris Muscle Muscles Of Facial Expression, Orbicularis Oris Muscle Musculus Orbicularis Oris Kenhub Orbicularis Oris ... Gallery of Orbicularis Oris Muscle. Tags: congenital absence of orbicularis oris muscle, depressor anguli oris muscle ... Orbicularis Oris Muscle Orbicularis Oris Muscle Muscular Musculoskeletal Anatomyzone Orbicularis Oris Small Model Muscles Of ...
*  Novelty Smiling and Facial Muscle Exerciser Lip Orthotics in Pink | Sammydress.com Mobile
... buy novelty smiling and facial muscle exerciser lip orthotics Pink at online decorative accents shop, sammydress.com Mobile. ...
*  Capturing physiology of emotion along facial muscles: a method of distinguishing feigned from involuntary expressions
... facial skin temperature measurements along the major facial muscles may be used in automated emotion assessment. ... the pattern of thermal variances along the facial muscles may assist in classifying voluntary and involuntary facial ... Capturing physiology of emotion along facial muscles: a method of distinguishing feigned from involuntary expressions. ... This work investigates differences in emotion-specific patterns of thermal variations along the major facial muscles. Using ...
*  Skin Care Tip: Facial Muscle Excercises
... submitted by Anonymous. A previous tip discussed the benefits of facial muscle ... We tone our body's muscles,,, why not our face to prevent or decrease the saging of muscles, and thus the skin of our face. ... This facial exercise firms your forehead. Repeat this exercise for ten times. Lips: Suck on your finger as hard as possible and ... This facial exercise firms your lips. Eyes: Sit with your eyes closed and relaxed. While keeping your eyes closed, look down ...
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Search our Facial Muscle Dysfunction database and connect with the best Facial Muscle Dysfunction professionals and other ...
*  Patent US3091237 - Facial muscle and tissue conditioning device - Google Patents
Oral facial exerciser. US3528655 *. 29 May 1968. 15 Sep 1970. American Physical Fitness Res. Facial muscle and skin ... CLAWSON N. SKINNER Unite tat This invention relates to muscle conditioning devices and more particularly to a facial muscle ... and deflatable with slightly pressurized air to alternately tension and relax the facial muscles to exercise the facial muscles ... the muscle tone of the facial tissues can be restored in a relatively brief period of time and/or the desired muscle tone level ...
*  drooping mouth corners Archives
... lower jawline and comes upward and inserts into the modiolus muscle as well as interconnects with other adjacent facial muscles ... The modiolus is the intersection of all muscles that act on the corner of the mouth. Since the DAO muscle pulls down on the ... Botox can be used for a wide variety of facial deanimation purposes that has aesthetic benefits. By far the most common facial ... muscle can also play a major role. This muscle originates from the ...
*  facial muscle | Definition of facial muscle by Webster's Online Dictionary
... facial muscle explanation. Define facial muscle by Webster's Dictionary, WordNet Lexical Database, Dictionary of Computing, ... Facial. Facial angle. facial artery. facial expression. facial gesture. facial index. -- facial muscle --. facial nerve. facial ... facial muscle - any of the skeletal muscles of the face. buccinator muscle, cheek muscle, face, human face, masseter, musculus ... facial recognition. facial tissue. facial vein. facially. Faciend. Facienda. Facient. Facies. Facies Hippocratica. Facile. ...
*  Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients - Full Text View - ClinicalTrials.gov
Latency from the root entry zone of facial nerve to the facial muscles [ Time Frame: up to 4 months ]. ... Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients. The recruitment status of this ... The abnormal potential from the offending vessel to the facial muscles will be detected on hemifacial spasm patients, so as to ... Observation of the Abnormal Potential From the Offending Vessel to the Facial Muscles of Hemifacial Spasm Patients. ...
*  Facial Muscles | A Dude's Guide. . . to everything
Action VerbsAdjectivesbehaviorBridgedudeDude'sEmotionExpressionExpressionsFacial ExpressionsFacial MusclesFreakFreaky Friday ... Tag Archives: Facial Muscles. A Dude's Guide to Health Who Needs A Psychiatrist When You've Got An iPhone?. March 20, 2013. ... ContemptDetecting LiesDisgustDr PauldudeDude'sExpressionsFacial MusclesFerretFox NetworkFreaky FridayLanguage And Cultureliars ... But it seems as if the mere physical act of twitching a few facial muscles is enough to fool the brain into thinking that, "If ...
*  Bad Toothache and Weak Facial Muscles on Left: 1 Cause
There is 1 uncommon condition that can cause Bad Toothache and Weak Facial Muscles on Left. ... The freeMD virtual doctor has found 1 condition that can cause Bad Toothache and Weak Facial Muscles on Left. ... The freeMD virtual doctor has found 1 condition that can cause Bad Toothache and Weak Facial Muscles on Left.. Mouse over to ... There is 1 uncommon condition that can cause Bad Toothache and Weak Facial Muscles on Left.. *Scuba Injuries ...
*  Botox Bluffton | Facial Muscle Relaxant Hilton Head
Board certified Frederick Weniger MD offers Botox injections to relax facial muscles that can cause wrinkles in the face for ... Botox® freezes tiny facial muscles by blocking the nerve signals transmitted between the facial muscles and brain, and it also ... As our skin ages, the movement of the facial muscles during speech and while making facial expressions leads to collagen ... Small amounts of Botox® are highly effective and produce results by freezing the muscles at the site of the injection. ...
*  Facial Muscle Exercises For Chubby Faces - Life Nagai
Doing facial muscle exercises every day keeps the face healthy and may prevent apparent aging process. Additionally, getting a ... If you're bothered by getting a chubby face, you can aquire a large amount of advantages of doing facial muscle exercises ... Each muscle exercise is made to concentrate on stretching and building certain muscles and lower excess fats within the ... This not just reduces excess fats within the oral cavity, it tones your muscle mass beneath your face too. So that you can chew ...
*  Facial Muscle Activity Patterns for Recognition of Utterances in Native and Foreign Language: Testing for its Reliability and...
Facial Muscle Activity Patterns for Recognition of Utterances in Native and Foreign Language: Testing for its Reliability and ... In this chapter we report the use of recording muscle activity of the facial muscles to determine the unspoken command from the ... "Facial Muscle Activity Patterns for Recognition of Utterances in Native and Foreign Language: Testing for its Reliability and ... "Facial Muscle Activity Patterns for Recognition of Utterances in Native and Foreign Language: Testing for its Reliability and ...
*  Fear of snakes and facial ractions: : A case of rapid emotional responding
The present thesis investigated the relationship between rapid facial muscle reactions and emotionally relevant stimuli. In ... Emotion, facial EMG, facial reactions, facial expressions, rapid responses, automatic responses, phobia, social fear, speech ... 1. Rapid Facial Reactions to Emotionally Relevant Stimuli. Open this publication in new window or tab ,,Rapid Facial Reactions ... In summary, the present results show that the facial EMG technique is sensitive to detecting rapid emotional reactions to ...
*  face skull diagram thieme facial muscles - Human Anatomy Chart
... face skull diagram thieme facial muscles image, face skull diagram thieme facial muscles gallery ... Head Muscles Anatomy. head muscles anatomy : Horse Front Muscle Anatomy Face Muscles Anatomy Human Head and Neck Muscles ... Erector Spinae Muscles Lumbar Plexus and Psoas Muscle Latissimus Dorsi Muscle Gluteal Muscle Gluteus Maximus Oblique Muscle and ... Diagram Head and Neck Muscles Model Upper Arm Muscle Diagram Human Head and Neck Anatomy Muscle Models Cat Muscle Anatomy ...
*  Download Facial Muscles Paralysis, paralysis
Facial Muscles Paralysis: 1 assigned downloads, like Bells Palsy from unique5stardeals ... Similar tags: facialmuscles • paralysis Top tags: sound effects • games shop • service repair manual • yamaha ... Bells palsy Comprehensive overview covers causes, treatment of this usually temporary facial paralysis. Definition Bells palsy ...
*  Lab Video - Parotid Gland, Facial Nerve & Facial Muscles
6. Clean and identify the muscles of facial expression related to the mouth. 640x480. 480x360. ... 3. Expose the parotid gland and its duct, carefully dissecting the branches of the facial nerve passing through it.. 640x480. ... 4. Identify the branches of the facial nerve within the parotid gland.. 640x480. 480x360. ...
*  Facial muscles - Stock Image F002/0393 - Science Photo Library
... of the facial muscles relative to the skeleton. The orbicularis oculi, frontalis, temporalis, levator labii superioris and ... facial expression muscles, facial muscles, front view, head, human, illustration, levator labii superioris, muscle, muscles of ... Caption: An anterolateral view (right side) of the facial muscles relative to the skeleton. The orbicularis oculi, frontalis, ... facial expression, muscles of the face, musculature, orbicularis oculi, portrait, realistic, white background, with skeleton, ...
*  Exercises for Sagging Facial Muscles and Hollow Cheeks
This is due to the shrinking of the supporting muscles. There are ... ... Just as exercise of the muscles of arms, legs and any other part of the body can improve them; exercise of the facial muscles ... Exercises for Sagging Facial Muscles and Hollow Cheeks. By Ismael D. Tabije. As years creep in, the cheeks sink in and hollows ... Exercises for Sagging Facial Muscles and Hollow Cheeks. by Ismael D. Tabije. Pushing the Limits of One's Life: Be Fit Up to 100 ...
*  Download The Behavioral Grooves' Podcast - Facial Muscles Speak Louder Than Words | Podbean
Dan's work is in facial coding - a diagnostic methodology that connects emotions to the expressions of the 42 facial muscles. ...
*  Video: Hands-Free, Facial Muscle-Controlled Wheelchair - TechCrunch
We have covered "intelligent" wheelchairs before, but one that can be controlled through facial muscles is new. A team of ...
*  Automated guided vehicle
Facial recognition. *Intellectual property. *Intelligent personal virtual voice assistants *Creating of avatar ...
*  Encephalitis
Facial nerve weakness can occur from inflammatory involvement of the facial nerve due to infection in the middle ear and/or ... Spread of infection occurs from the cells of the mastoid tip down along the adjacent sternomastoid and digastric neck muscles. ... While idiopathic facial paralysis (Bell's palsy) is common in adults, children with an acute onset facial palsy must be ... 2. Facial paralysis - Paralysis of the seventh cranial nerve can occur from middle ear or mastoid inflammation. The facial ...

Facial muscles: The facial muscles are a group of striated skeletal muscles innervated by the facial nerve (cranial nerve VII) that, among other things, control facial expression. These muscles are also called mimetic muscles.Facial nerve paralysisElectroneuronography: Electroneuronography or electroneurography (ENoG) is a neurological non-invasive test that was first described by Esslen and Fisch in 1979 and is used to examine the integrity and conductivity of a peripheral nerve. It consists of a brief electrical stimulation of the nerve in one point underneath the skin, and at the same time recording the electrical activity (compound action potentials) at another point of the nerve's trajectory in the body.Emotional responsivity: Emotional responsivity refers to the ability to acknowledge an affective stimuli by exhibiting emotion. Any response, whether it is appropriate or not, would showcase the presence of this phenomena.Zygoma reduction plasty: Zygoma reduction plasty, a plastic and cosmetic surgery, by making the zygoma smaller surgically to achieve a desired plastic and cosmetic outcome.Masticatory force: Masticatory force or force of mastication is defined as a force, which is created by the dynamic action of the masticatory muscles during the physiological act of chewing.University of Miami Division of Surgical Neurooncology: The Division of Surgical Neurooncology in the Department of Neurological Surgery and Sylvester Comprehensive Cancer Center at the University of Miami is one of the largest and most complete programs for brain tumor treatment in the United States. As the only academic medical center in the region, the University of Miami offers a unique and comprehensive approach to these conditions, with interdisciplinary discussion between neurosurgery, neurology, radiation oncology, and medical oncology.Aging movement control: Normal aging movement control in humans is about the changes on the muscles, motor neurons, nerves, sensory functions, gait, fatigue, visual and manual responses, in men and women as they get older but who do not have neurological, muscular (atrophy, dystrophy...) or neuromuscular disorder.Sialoblastoma: A sialoblastoma is a low-grade salivary gland neoplasm that recapitulates primitive salivary gland anlage. It has previously been referred to as congenital basal cell adenoma, embryoma, or basaloid adenocarcinoma.Protein turnover: Protein turnover is the balance between protein synthesis and protein degradation. More synthesis than breakdown indicates an anabolic state that builds lean tissues, more breakdown than synthesis indicates a catabolic state that burns lean tissues.Myokine: A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions.Bente Klarlund Pedersen , Thorbjörn C.Vascular smooth muscleMuscle contraction: Muscle contraction is the activation of tension-generating sites within muscle fibers. In physiology, muscle contraction does not mean muscle shortening because muscle tension can be produced without changes in muscle length such as holding a heavy book or a dumbbell at the same position.

(1/322) Electrical stimulation as a therapeutic option to improve eyelid function in chronic facial nerve disorders.

PURPOSE: To establish whether it is possible to improve orbicularis oculi muscle function in the eyelids of patients with a chronic seventh cranial nerve palsy by using transcutaneous electrical stimulation to the point at which electrical stimulation induces a functional blink. METHODS: Ten subjects (one woman, nine men) aged 36 to 76 with chronic, moderate to severe facial nerve palsy were recruited into the study. Voluntary and spontaneous eyelid movements were assessed, using an optical measuring system, before, during, and after a 3-month treatment period. Voluntary and spontaneous lid velocities were also measured and compared with eyelid kinematic data in normal subjects (12 women, 18 men; age range, 22-56 years). RESULTS: Therapeutic electrical stimulation applied over 3 months produced improvement in eyelid movement (>2 mm) in 8 of 10 patients during voluntary eyelid closure. However, there was no significant improvement recorded in spontaneous blink amplitudes or peak downward-phase velocity of the upper eyelid. This regimen of stimulation failed to recover function well enough that a functional blink could be induced in the paretic eyelid by electrical stimulation. CONCLUSIONS: Electrical stimulation using transcutaneous electrical nerve stimulators units can improve voluntary eye closure, apparently because of a reduction in stiffness of eyelid mechanics, rather than an improvement of muscle function. Investigation of alternative stimulation regimens is warranted.  (+info)

(2/322) Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.

Anticonvulsants cause dyskinesias more commonly than has been appreciated. Diphenylhydantoin (DPH), carbamazepine, primidone, and phenobarbitone may cause asterixis. DPH, but not other anticonvulsants, may cause orofacial dyskinesias, limb chorea, and dystonia in intoxicated patients. These dyskinesias are similar to those caused by neuroleptic drugs and may be related to dopamine antagonistic properties possessed by DPH.  (+info)

(3/322) MR imaging of Dejerine-Sottas disease.

We report the MR findings in two patients with clinically and histologically proved Dejerine-Sottas disease. One patient had spinal involvement with multiple thickened and clumped nerve roots of the cauda equina; the second had multiple enlarged and enhancing cranial nerves. Although these findings are not specific for Dejerine-Sottas disease, they are suggestive of the diagnosis, which is further corroborated with history and confirmed with sural nerve biopsy and laboratory studies.  (+info)

(4/322) MR appearance of rhinoscleroma.

BACKGROUND AND PURPOSE: We describe the MR imaging appearance of rhinoscleroma, an endemic, chronic, granulomatous disease whose causative agent is Klebsiella rhinoscleromatis. METHODS: The study included 15 patients (nine males and six females; mean age, 25 years; range, 13-36 years) with rhinoscleroma. MR imaging was performed in all patients. The signal intensity of the nasal masses was compared with that of fat, muscle, and CSF on both T1- and T2-weighted images. All cases were proved by histopathologic examination. RESULTS: The nasal masses were bilateral and symmetrical (n = 6), asymmetrical (n = 4), or unilateral (n = 5). They extended through the anterior nares (n = 9) or posterior choana into the nasopharynx (n = 3). They obstructed the ostiomeatal units with retained secretions in the related sinuses (n = 10). On T1-weighted images, rhinoscleroma showed striking (n = 9) or mild (n = 6) high signal intensity relative to muscle and CSF, but less hyperintensity than fat. On T2-weighted images, the nasal masses showed homogeneous high signal intensity (n = 10) or heterogeneous high signal intensity associated with hypointense foci (n = 5). They were hyperintense relative to fat and muscle, but less hyperintense than CSF. CONCLUSION: The hypertrophic stage of rhinoscleroma has characteristic mild to marked high signal intensity on both T1- and T2-weighted MR images.  (+info)

(5/322) The neuromuscular control of birdsong.

Birdsong requires complex learned motor skills involving the coordination of respiratory, vocal organ and craniomandibular muscle groups. Recent studies have added to our understanding of how these vocal subsystems function and interact during song production. The respiratory rhythm determines the temporal pattern of song. Sound is produced during expiration and each syllable is typically followed by a small inspiration, except at the highest syllable repetition rates when a pattern of pulsatile expiration is used. Both expiration and inspiration are active processes. The oscine vocal organ, the syrinx, contains two separate sound sources at the cranial end of each bronchus, each with independent motor control. Dorsal syringeal muscles regulate the timing of phonation by adducting the sound-generating labia into the air stream. Ventral syringeal muscles have an important role in determining the fundamental frequency of the sound. Different species use the two sides of their vocal organ in different ways to achieve the particular acoustic properties of their song. Reversible paralysis of the vocal organ during song learning in young birds reveals that motor practice is particularly important in late plastic song around the time of song crystallization in order for normal adult song to develop. Even in adult crystallized song, expiratory muscles use sensory feedback to make compensatory adjustments to perturbations of respiratory pressure. The stereotyped beak movements that accompany song appear to have a role in suppressing harmonics, particularly at low frequencies.  (+info)

(6/322) Features of cortically evoked swallowing in the awake primate (Macaca fascicularis).

Although the cerebral cortex has been implicated in the control of swallowing, the output organization of the cortical swallowing representation, and features of cortically evoked swallowing, remain unclear. The present study defined the output features of the primate "cortical swallowing representation" with intracortical microstimulation (ICMS) applied within the lateral sensorimotor cortex. In four hemispheres of two awake monkeys, microelectrode penetrations were made at 5 mm deep to the cortical surface corresponding to both the white matter underlying the CMA and the frontal operculum; EMG patterns of swallows elicited from these four cortical regions showed some statistically significant differences. Whereas swallowing ONLY was evoked at some sites, particularly within the deep cortical area, swallowing was more frequently evoked together with other orofacial responses including rhythmic jaw movements. Increasing ICMS intensity increased the magnitude, and decreased the latency, of the swallow-related EMG burst in the genioglossus muscle at some sites. These findings suggest that a number of distinct cortical foci may participate in the initiation and modulation of the swallowing synergy as well as in integrating the swallow within the masticatory sequence.  (+info)

(7/322) Direct injection of liposome-encapsulated doxorubicin optimizes chemomyectomy in rabbit eyelid.

PURPOSE: Doxorubicin chemomyectomy presently represents the only permanent, nonsurgical treatment for blepharospasm and hemifacial spasm. The major deterrent to an otherwise extremely effective treatment protocol is the development in patients of localized inflammation, discomfort, and skin injury over the injection site. As a potential alternative therapy, Doxil (Sequus, Menlo Park, CA), a liposome-encapsulated form of doxorubicin that displays tissue-selective therapeutic effects compared with free doxorubicin, was examined. These effects have been related to its increased retention in tissues and its sustained release over time. For the skin, Doxil is classified as an irritant rather than a vesicant. METHODS: Rabbits received direct injections of 1, 2, or 3 mg Doxil alone or in sequence with other agents directly into the lower eyelids. The treated eyelids were examined daily for signs of skin injury. One month after the last injection, the rabbits were euthanatized, and their eyelids were examined histologically for the effect of Doxil on the orbicularis oculi muscle and the skin. RESULTS: At equivalent milligram doses of free doxorubicin, Doxil spared the skin from injury. Doxil was only approximately 60% as effective in killing muscles as the same milligram dose of free doxorubicin. However, either two injections of Doxil spaced 2 months apart or preinjury of the lid with bupivacaine before a single dose of Doxil treatment resulted in increased muscle loss compared with a single dose of Doxil alone and was as effective as free doxorubicin. Higher doses of Doxil did not increase the desired myotoxic effect; apparently, the dose effect levels off at a maximum. Signs of skin injury were minimal; there were small or no adverse skin changes at the maximum effective myotoxic doses. CONCLUSIONS: Injection of Doxil resulted in significant reduction of skin injury compared with doxorubicin alone. Although single injections of Doxil were myotoxic, multiple exposure of the eyelid to the liposome-encapsulated form substantially improved myotoxicity while sparing the skin. Repeated doses of the liposome-encapsulated form of doxorubicin may be as clinically effective as free doxorubicin injections and may produce fewer unwanted side effects.  (+info)

(8/322) Differentiation of avian craniofacial muscles: I. Patterns of early regulatory gene expression and myosin heavy chain synthesis.

Myogenic populations of the avian head arise within both epithelial (somitic) and mesenchymal (unsegmented) mesodermal populations. The former, which gives rise to neck, tongue, laryngeal, and diaphragmatic muscles, show many similarities to trunk axial, body wall, and appendicular muscles. However, muscle progenitors originating within unsegmented head mesoderm exhibit several distinct features, including multiple ancestries, the absence of several somite lineage-determining regulatory gene products, diverse locations relative to neuraxial and pharyngeal tissues, and a prolonged and necessary interaction with neural crest cells. The object of this study has been to characterize the spatial and temporal patterns of early muscle regulatory gene expression and subsequent myosin heavy chain isoform appearance in avian mesenchyme-derived extraocular and branchial muscles, and compare these with expression patterns in myotome-derived neck and tongue muscles. Myf5 and myoD transcripts are detected in the dorsomedial (epaxial) region of the occipital somites before stage 12, but are not evident in the ventrolateral domain until stage 14. Within unsegmented head mesoderm, myf5 expression begins at stage 13.5 in the second branchial arch, followed within a few hours in the lateral rectus and first branchial arch myoblasts, then other eye and branchial arch muscles. Expression of myoD is detected initially in the first branchial arch beginning at stage 14.5, followed quickly by its appearance in other arches and eye muscles. Multiple foci of myoblasts expressing these transcripts are evident during the early stages of myogenesis in the first and third branchial arches and the lateral rectus-pyramidalis/quadratus complex, suggesting an early patterned segregation of muscle precursors within head mesoderm. Myf5-positive myoblasts forming the hypoglossal cord emerge from the lateral borders of somites 4 and 5 by stage 15 and move ventrally as a cohort. Myosin heavy chain (MyHC) is first immunologically detectable in several eye and branchial arch myofibers between stages 21 and 22, although many tongue and laryngeal muscles do not initiate myosin production until stage 24 or later. Detectable synthesis of the MyHC-S3 isoform, which characterizes myofibers as having "slow" contraction properties, occurs within 1-2 stages of the onset of MyHC synthesis in most head muscles, with tongue and laryngeal muscles being substantially delayed. Such a prolonged, 2- to 3-day period of regulatory gene expression preceding the onset of myosin production contrasts with the interval seen in muscles developing in axial (approximately 18 hr) and wing (approximately 1-1.5 days) locations, and is unique to head muscles. This finding suggests that ongoing interactions between head myoblasts and their surroundings, most likely neural crest cells, delay myoblast withdrawal from the mitotic pool. These descriptions define a spatiotemporal pattern of muscle regulatory gene and myosin heavy chain expression unique to head muscles. This pattern is independent of origin (somitic vs. unsegmented paraxial vs. prechordal mesoderm), position (extraocular vs. branchial vs. subpharyngeal), and fiber type (fast vs. slow) and is shared among all muscles whose precursors interact with cephalic neural crest populations. Dev Dyn 1999;216:96-112.  (+info)

  • eyelid
  • Surgical facelifts are effectively combined with eyelid surgery (blepharoplasty) and other facial procedures and are typically performed under general anesthesia or deep twilight sleep. (wikipedia.org)
  • The Müller's muscle, or the superior tarsal muscle, in the upper eyelid and the inferior palpebral muscle in the lower 3 eyelid are responsible for widening the eyes. (wikipedia.org)
  • brass
  • It is also one of the muscles used in the playing of all brass instruments and some woodwind instruments. (wikipedia.org)
  • and although this collapse lessens the uncontrollable twitching of the muscles, the newly relaxed status deprives the player of the lip flexibility needed to play a brass instrument. (wikipedia.org)
  • skin
  • In 1919 Dr. Passot was known to publish one of the first papers on face-lifting, this consisted mainly on the elevating and redraping of the facial skin. (wikipedia.org)
  • cause
  • These muscles also cause wrinkles at right angles to the muscles' action line. (wikipedia.org)
  • Satoyoshi syndrome, also known as Komura-Guerri syndrome, is a rare progressive disorder of presumed autoimmune cause, characterized by painful muscle spasms, alopecia, diarrhea, endocrinopathy with amenorrhoea and secondary skeletal abnormalities. (wikipedia.org)
  • The clefts cause problems with facial muscle development. (wikipedia.org)
  • form
  • Gestalt psychologists theorize that a face is not merely a set of facial features, but is rather something meaningful in its form. (wikipedia.org)
  • human
  • Facial appearance is vital for human recognition and communication. (wikipedia.org)
  • The skill of facial approximation is closely associated and related to forensic anthropology in that an artist specializes in the reconstruction of the remains of a human body. (wikipedia.org)
  • appearance
  • Until recently, it was misinterpreted as a sphincter, or circular muscle, but it is actually composed of four independent quadrants that interlace and give only an appearance of circularity. (wikipedia.org)
  • A facelift, technically known as a rhytidectomy (from Ancient Greek ῥυτίς (rhytis) "wrinkle" + ἐκτομή (ektome) "excision", surgical removal of wrinkles), is a type of cosmetic surgery procedure used to give a more youthful facial appearance. (wikipedia.org)
  • position
  • Computer systems vary, in that some computerized systems used 3D animation software to model the face onto the skull, while other systems use a virtual sculpture system with Haptic feedback Haptic Feedback- The ability to feel the surface of the skull during analysis and also provide important skeletal details for facial reconstruction such as muscle attachment strength, position of eye, position of malar tubercle etc. (wikipedia.org)
  • simple
  • Classifications are a complete lateral facial cleft, simple macrostomia, macrostomia with diastasis of the facial musculature, and isolated facial musculature diastasis. (wikipedia.org)