Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers. (1/403)

BACKGROUND AND METHODS: After endoscopic treatment to control bleeding of peptic ulcers, bleeding recurs in 15 to 20 percent of patients. In a prospective, randomized study, we compared endoscopic retreatment with surgery after initial endoscopy. Over a 40-month period, 1169 of 3473 adults who were admitted to our hospital with bleeding peptic ulcers underwent endoscopy to reestablish hemostasis. Of 100 patients with recurrent bleeding, 7 patients with cancer and 1 patient with cardiac arrest were excluded from the study; 48 patients were randomly assigned to undergo immediate endoscopic retreatment and 44 were assigned to undergo surgery. The type of operation used was left to the surgeon. Bleeding was considered to have recurred in the event of any one of the following: vomiting of fresh blood, hypotension and melena, or a requirement for more than four units of blood in the 72-hour period after endoscopic treatment. RESULTS: Of the 48 patients who were assigned to endoscopic retreatment, 35 had long-term control of bleeding. Thirteen underwent salvage surgery, 11 because retreatment failed and 2 because of perforations resulting from thermocoagulation. Five patients in the endoscopy group died within 30 days, as compared with eight patients in the surgery group (P=0.37). Seven patients in the endoscopy group (including 6 who underwent salvage surgery) had complications, as compared with 16 in the surgery group (P=0.03). The duration of hospitalization, the need for hospitalization in the intensive care unit and the resultant duration of that stay, and the number of blood transfusions were similar in the two groups. In multivariate analysis, hypotension at randomization (P=0.01) and an ulcer size of at least 2 cm (P=0.03) were independent factors predictive of the failure of endoscopic retreatment. CONCLUSIONS: In patients with peptic ulcers and recurrent bleeding after initial endoscopic control of bleeding, endoscopic retreatment reduces the need for surgery without increasing the risk of death and is associated with fewer complications than is surgery.  (+info)

Endovascular treatment of multiple aneurysms involving the posterior intracranial circulation. (2/403)

The results of surgery on multiple intracranial aneurysms tha involve the vertebrobasilar circulation are poor, and associated patient mortality remains high. We describe the endovascular treatment of four patients with mutiple aneurysms that involved the posterior intracrancial circulation. Satisfactory occlusion of all aneurysms was achieved by using electrolytically detachable coils, and all patients had a good clinical recovery. Our early experience suggests that endovascular coil occlusion may be a particularly suitable method for treating this high-risk condition.  (+info)

Comparison of adrenaline injection and bipolar electrocoagulation for the arrest of peptic ulcer bleeding. (3/403)

BACKGROUND: Peptic ulcers with active bleeding or a non-bleeding visible vessel require aggressive endoscopic treatment. AIMS: To determine whether endoscopic adrenaline injection alone or contact probe therapy following injection is a suitable treatment for peptic ulcer bleeding. METHODS: A total of 96 patients with active bleeding or non-bleeding visible vessels received adrenaline alone, bipolar electrocoagulation alone, or combined treatment (n=32 in each group). RESULTS: Initial haemostasis was not achieved in one patient in the adrenaline group, two in the gold probe group, and two in the injection gold probe group (p>0.1). Rebleeding episodes were fewer in the injection gold probe group (2/30, 6.7%) than in the gold probe group (9/30, 30%, p=0.04) and in the adrenaline group (11/31, 35.5%, p=0.01). Treatment failure (other therapy required) was rarer in the injection gold probe group (4/32, 12.5%) than in the adrenaline group (12/32, 37.5%, p=0.04). The volume of blood transfused after entry of the study was less in the injection gold probe group (mean 491 ml) than in the adrenaline group (1548 ml, p<0. 0001) and the gold probe group (1105 ml, p<0.01). Duration of hospital stay, numbers of patients requiring urgent surgery, and death rate were not statistically different among the three groups. CONCLUSIONS: For patients with peptic ulcer bleeding, combined adrenaline injection and gold probe treatment offers an advantage in preventing rebleeding and decreasing the need for blood transfusion.  (+info)

Electromagnetic interference of an external temporary pacemaker during maxillofacial and neck surgery. (4/403)

Indirect inhibition of an external temporary pacemaker by electrocautery is reported. Before induction of general anesthesia for a hemimaxillectomy and radical neck dissection, a temporary transvenous demand pacemaker was inserted into a patient with a first-degree atrioventricular block and complete left bundle-branch block. Although we provided common precautions to prevent electromagnetic interference by electrocautery, pacing failure still occurred. It was thought to be caused by current dispersing from the active electrocautery electrode. This case suggests that occipital placement of the electrocautery ground plate should be considered during neck surgery in a patient requiring a temporary pacemaker.  (+info)

Forebrain ischaemia with CA1 cell loss impairs epileptogenesis in the tetanus toxin limbic seizure model. (5/403)

There is a long-standing controversy as to whether Ammon's horn sclerosis is the result or the cause of severe limbic epilepsy. In the tetanus toxin model of limbic epilepsy, rats have intermittent spontaneous fits over a period of 3-6 weeks after injection of tetanus toxin into the hippocampus. The fits then usually remit and the EEG returns to normal. In a few rats, however, the fits recur some weeks to months later, and it was previously found that in these rats there was gross cell loss in area CA1 of the dorsal hippocampus (distant from the injection site in ventral hippocampus). Such cell loss might either promote recurrence of fits or be the result of the recurrence. In the present experiment, the effect of previous induction of CA1 cell loss by transient 4-vessel occlusion cerebral ischaemia on the subsequent development of the tetanus toxin-induced epilepsy was studied, using continuous time-lapse video monitoring to assess the number of fits. The hypothesis that the previous forebrain ischaemia would predispose rats to reoccurring fits was not supported: no rats in the ischaemia group had reoccurring fits and additionally fits were delayed and fewer occurred than in the control groups.  (+info)

Relation of cervical glandular intraepithelial neoplasia to microinvasive and invasive adenocarcinoma of the uterine cervix: a study of 121 cases. (6/403)

AIMS: To examine the relation between invasive adenocarcinoma and its alleged precursor, cervical glandular intraepithelial neoplasia (CGIN), and to assess the management and outcome of CGIN and the validity of using the term "microinvasive adenocarcinoma." METHODS: The clinical and pathological features of 121 cases of glandular neoplasia of the cervix diagnosed between the years 1990 to 1995 were examined for the following: histological diagnosis, smear records, type of treatment, the association between the precursor lesions and invasive disease, and follow up. RESULTS: 27 cases were identified as low grade CGIN (L-CGIN) and 38 as high grade CGIN (H-CGIN), 10 as microinvasive adenocarcinoma (less than 5 mm in depth), and 46 as invasive adenocarcinoma. The ratio of non-invasive to invasive disease was 1.12:1. The mean age of women was 39, 43, 43, and 48 years for L-CGIN, H-CGIN, microinvasive, and invasive adenocarcinoma, respectively. L-CGIN was seen in 13% and 18% of H-CGIN and microinvasive disease, respectively. H-CGIN was seen in 100% of microinvasive and 26% of invasive adenocarcinomas. The available smears before diagnosis predicted 59% of L-CGIN, 70% of H-CIGN, 100% of microinvasive adenocarcinoma, and 32% of invasive adenocarcinomas. Treatment of 74% of L-CGIN, 52% of H-CIGN, and 10% of microinvasive adenocarcinoma was by diathermy loop excision only. The remaining cases had hysterectomy. Residual disease was found in 43%, 50%, and 33% of hysterectomies for L-CGIN, H-CGIN, and microinvasive adenocarcinoma, respectively. This is correlated with positive margins, or disease within 3 mm of margins on loop specimens. Cervical smear follow up for two to seven years revealed no recurrence of glandular lesions in any of the cases of CGIN or microinvasive adenocarcinoma. CONCLUSIONS: Precursor glandular lesions tend to progress to invasive carcinoma. There is a progressive increase in age of patients from L-CGIN to invasive disease, a span of approximately 10 years. There is a high association between H-CGIN and invasive disease. In the management of such alleged precursors, it is important to ensure adequate free margins of at least 3 mm. Microinvasive adenocarcinoma appears to have an excellent prognosis if treated by hysterectomy.  (+info)

New bipolar diathermy forceps with automatic dripping and flushing--technical note. (7/403)

A new bipolar diathermy forceps system was developed to solve the problems of constant, pressure-limited flow rate, and one-sided irrigation. A roller pump, activated synchronously by pressing a foot switch, feeds dripping and flushing solution to the target tissue via the tip at both ends of the forceps. This system is volume-limited. Continuous compression of the foot switch first activates the flushing function, which continues for less than 1 second, during which time bleeding spots can be detected. The flow then changes automatically to the dripping function to suppress tip burning and prevent damage to the surrounding tissues from heat and current leakage. Repeated pressing of the foot switch initiates the jet irrigation function (continuous high flow rates), allowing irrigation of hematomas and removal of excess debris.  (+info)

Morphological changes induced by extensive endobronchial electrocautery. (8/403)

Due to recent improvements of safety conditions for therapeutic devices, electrocautery is being considered with renewed interest in the field of therapeutic bronchoscopy. The efficiency of this technique for destructing intraluminal tumours is well documented and makes it an attractive alternative to Yttrium aluminium garnet (YAG) laser photo-coagulation. Little is known, however, about the morphologic changes induced by electrocautery within the bronchial wall structures. This information is, however, important since electrocautery has been proposed as an alternative to other techniques to treat superficial tumours of the bronchial wall. Soft coagulation, with autostop, using two different power setting (40 and 120 W), produced by a new generation of high frequency voltage regulated generators was applied circumferentially to the trachea or left main bronchus, in a series of 52 piglets. Early (48 h) and late effects (6 weeks) were assessed through gross examination (bronchoscopy and autopsy) and light microscopy. Early effects of electrocautery included coagulation necrosis of the mucosa only and intense acute inflammation extending deep into the bronchial structure. The inflammatory phase progressively resolved while extensive transmural fibrosis and deterioration of the cartilage plates developed. The nature and extent of these lesions did not depend upon the energy delivered (40 W versus 120 W). Retractile scar formation and loss of cartilaginous support then produced iatrogenic secondary stenoses. These results do not question the use of electrocautery to palliate endoluminal tumours but should make operators careful when treating extensive infiltration of the bronchial wall.  (+info)

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