Therapeutic drug monitoring

Arrestee Drug Abuse Monitoring

European Monitoring Centre for Drugs and Drug Addiction

Uppsala Monitoring Centre

Continuous glucose monitor

Data monitoring committee

Viral load monitoring for HIV

Sterilant gas monitoring

Doppler fetal monitor

Monitoring the Future

Monitoring (medicine)

J. Michael Pearson

Anesthesia awareness

Causes of hearing loss

Financial Monitoring Unit

Tareck El Aissami

3,4-Methylenedioxyamphetamine

Primidone

Atypical antipsychotic

Valproate

CYP2A6

Paliperidone palmitate

Forensic chemistry

Diazepam

War on drugs

Fetal alcohol spectrum disorder

Sirolimus

Butonitazene

List of benzimidazole opioids

Propylene glycol

20232

• Today (September 29, 2023) NDA has concluded a compliance enforcement operation targeting illegal drug outlets in Kampala extra region, covering four divisions of Kawempe, Nakawa, Makindye and Rubaga," he said. (monitor.co.ug)
• This testimony summarizes the information contained in GAO's September 2023 report, entitled Medicare Part D: CMS Should Monitor Effects of Rebates on Plan Formularies and Beneficiary Spending ( GAO-23-105270 ). (gao.gov)

Illicit5

• Illicit drugs like heroin and marijuana are most often present in drug-related overdose deaths, but opioids are part of the picture 33 percent of the time. (sciencedaily.com)
• The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) is the leading authority on illicit drugs in the European Union. (europa.eu)
• One innovative new approach being trialled by the agency is hair drug testing , which can detect illicit drugs and their breakdown products (metabolites) in hair. (europa.eu)
• Some public health officials are monitoring wastewater to track illicit drugs like methamphetamine and fentanyl, just as they did to follow COVID. (wusf.org)
• use of alcohol, cigarettes, and illicit and prescription drugs either held at the same level or, in many cases, declined among American teens. (drugprevent.org.uk)

PDMPs5

• Information from prescription drug monitoring programs (PDMPs) can alert you to opportunities to provide potentially lifesaving information and interventions. (cdc.gov)
• To tackle this epidemic, a lot of effort has been put into state-run prescription drug monitoring programs (PDMPs) that establish databases of prescriptions written and filled, with secure online portals for accessing that data. (sas.com)
• An essential tool in fighting this epidemic has been implementing and using Prescription Drug Monitoring Programs (PDMPs). (health.mil)
• PDMPs track controlled substance prescription information to include: drug name and strength, quantity, prescriber, pharmacy, and payment type. (health.mil)
• Prescription drug monitoring programs (PDMPs) are electronic databases that allow health care professionals to view their patients' controlled-substance prescription histories in order to better inform prescribing, dispensing, and treatment decisions. (pewtrusts.org)

Patient's5

• It is an individualized strategy that includes regular assessments of a patient's serum drug levels. (eurekalert.org)
• INSPECT tracks a patient's drug history in Indiana, the prescribers involved, the pharmacies used, and the pharmacists who dispensed the drugs. (medscape.com)
• Researchers at Brigham and Women's Hospital in Boston have developed an implant, notably as small as a grain of rice, that can test the effects of drugs on a patient's brain tumor in real-time during surgery. (yahoo.com)
• The technique known as microdialysis currently stands as one of the more minimally invasive sampling options for testing the impact of drugs on brain tumors, but even that requires an entire catheter to be inserted into the patient's skull cavity. (yahoo.com)
• For example, if a side effect of a medication is liver damage, then monitoring a patient's liver enzymes for evidence of early liver injury can prevent serious disease by alerting the physician to this side effect so that the medication can be discontinued before it causes actual liver damage. (blogspot.com)

Overdoses5

• These cultural icons share a tragic connection: They all died too young from accidental overdoses of prescription painkillers - mostly synthetic opioids - or a cocktail of prescription drugs. (sas.com)
• According to the US Centers for Disease Control and Prevention (CDC), drug overdose is the leading cause of accidental death in the US, with 47,055 lethal drug overdoses in 2014. (sas.com)
• Deaths attributed to drug overdoses are constantly on the rise, but drug trends are frequently changing and often differ across geographical regions. (nist.gov)
• Testing sewer water can illustrate exactly what is hot and where, offering a much more accurate picture of the drug crisis than simply counting overdoses. (wusf.org)
• The PDMP monitors drugs on Schedules II-V and collects data on naloxone/narcan dispensing and non-fatal drug overdoses. (ojp.gov)

Antineoplastic1

• Preparing antineoplastic drugs for intravenous treatment was the major task of all study participants. (bmj.com)

20221

• Such monitoring of rebates will be particularly important as the agency implements the provisions of the Inflation Reduction Act of 2022, which will change Part D plan sponsor, beneficiary, and Medicare drug spending responsibility and may affect formulary design and rebates. (gao.gov)

Toxicity6

• For certain drugs, this is impracticable, while insufficient levels will lead to undertreatment or resistance, and excessive levels can lead to toxicity and tissue damage. (wikipedia.org)
• TDM may increase the probability of a successful outcome, prevent drug-related toxicity and potentially prevent the emergence of antifungal drug resistance. (nih.gov)
• The major indications of TDM are suspicion of drug toxicity, lack of therapeutic response, assessment of compliance, therapy assessment following a change in dosage regimen or clinical state of the patient, potential drug interactions and when manifestation of toxicity and disease state are similar. (vin.com)
• In certain conditions, the free drug concentration may be significantly higher than expected from the measured total concentration, and consequently toxicity may occur (Dasgupta, 2002). (vin.com)
• The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. (medscimonit.com)
• The majority (39%) of those that failed to get approval were due to a poor understanding of pharmacokinetics which has an impact on a drug compound's efficacy, safety and toxicity due to under- and over-dosing of drugs. (stanford.edu)

Controlled substances1

• To find out whether Indiana's prescription drug monitoring program, known as INSPECT , affects pharmacists' dispensing of controlled substances, Norwood and his colleague, Eric Wright, PhD, from Georgia State University, surveyed more than 1500 pharmacists. (medscape.com)

Adherence2

• The researchers developed the adherence monitor by incorporating minute amounts of an alcohol into a gel capsule. (medgadget.com)
• Bethlehem, PA - September 19, 2018 - Saladax Biomedical Inc., a diagnostics company providing kits to test drug blood levels for personalized dose management and adherence, announced today that it welcomes new guidelines from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) that "strongly recommend" monitoring levels of 5-Fluorouracil (5-FU) in patients on treatment. (saladax.com)

Cyclosporine1

• Drugs for which TDM has been proposed are anti-epileptic drugs, cardiovascular drugs, antimicrobials, theophylline, cyclosporine and thyroid hormones. (vin.com)

Amikacin2

• Therapeutic drug monitoring of amikacin in preterm and term neonates with late-onset sepsis. (bvsalud.org)
• Amikacin is an aminoglycoside antibiotic that is frequently used for the treatment of neonatal late-onset sepsis , for which therapeutic drug monitoring (TDM) is advised. (bvsalud.org)

Efficacy of exec1

• a half-dozen sociologists and legal experts were interviewed about the efficacy of executing drug smugglers. (al-monitor.com)

Opioids1

• And, in fact, there was no reason to believe opioids would create such a problem particularly when Purdue Pharma launched a campaign in 1996 informing patients and doctors that a new, safe drug was available to combat pain. (sciencedaily.com)

Concentration12

• Many different professionals (physicians, clinical pharmacists, nurses, medical laboratory scientists, etc.) are involved with the various elements of drug concentration monitoring, which is a truly multidisciplinary process. (wikipedia.org)
• potential patient compliance problems that might be remedied through concentration monitoring. (wikipedia.org)
• For patients with HIV or cancer , drug concentration in the blood can be a matter of life and death. (pharmacytimes.com)
• Practically, it consists in blood collection from a patient receiving a drug, serum/plasma assay of the drug concentration and comparison with a therapeutic range (Gross, 1998). (vin.com)
• The main purpose of TDM is to assist the practitioner in drug regimen adjustment to reach an optimal drug concentration ensuring an adequate therapeutic response without drug-induced adverse effects. (vin.com)
• With PDC, the plasma drug concentration. (vin.com)
• The drug concentration must be always interpreted in light of the clinical response to the treatment, the characteristics (age, body weight, breed, species. (vin.com)
• Moreover, as assessing drug concentration could suggest that the drug is more toxic than that of competitors for which no assay is available, drug companies are not prone to encourage development of TDM. (vin.com)
• TDM assesses only total drug concentration. (vin.com)
• This causes a rise in current which can be measured and correlated to target drug concentration. (stanford.edu)
• Fig. 1 Schematic illustrating the insertion of implantable nanoporous electrodes into tumor tissues for long-term monitoring of intra-tumoral drug concentration at multiple tumor regions. (stanford.edu)
• The goal of this study was to develop a method of de-convoluting the UV-Vis spectra measured in situ to not only obtain the concentration of free drug in the presence of light absorbing nanoparticles but also to quantify theconcentration of nanoparticles present in suspensions.interplay between dissolution, solubility and permeability. (pion-inc.com)

Compliance2

• Medication compliance for people taking psychiatric drugs is notoriously hit and miss. (healthyplace.com)
• Because of that, the Food and Drug Administration (FDA) recently approved a form of aripiprazole (Abilify) that digitally tracks medication compliance in patients with schizophrenia, some forms of bipolar, and some cases of depression according to Psychiatric Times . (healthyplace.com)

Concentrations of drugs2

• It can be based on a a priori pharmacogenetic, demographic and clinical information, and/or on the a posteriori measurement of blood concentrations of drugs (pharmacokinetic monitoring) or biological surrogate or end-point markers of effect (pharmacodynamic monitoring). (wikipedia.org)
• Next steps include optimizing the sensitivity of the biosensor so it can detect low concentrations of drugs or biomolecules in the blood, the study concluded. (pharmacytimes.com)

Preventing drug diversion1

• These programs aim to protect public health and safety, assist providers and pharmacists in identifying potential prescription medication misuse, and aid in preventing drug diversion. (health.mil)

Measured drug concentrations1

• Drug dosage adjustments based on the assumption that measured drug concentrations are reliable predictors of clinical response may be risky. (vin.com)

Chemotherapy3

• 5-FU is a commonly used chemotherapy drug that is the backbone of treatment regimens for colorectal cancer, other gastroenterology cancers, head and neck cancer and other solid cancers. (saladax.com)
• Application of an innovative high-throughput liquid chromatography-tandem mass spectrometry method for simultaneous analysis of 18 hazardous drugs to rule out accidental acute chemotherapy exposures in health care workers. (cdc.gov)
• Our aim was to develop an analytical method for simultaneous detection and quantification of widely used cancer drugs to rule out accidental acute chemotherapy exposures in health care workers. (cdc.gov)

Adverse6

• Adverse events were similar for both treatment groups as well, but infusion reactions were less frequent in patients who received therapeutic drug monitoring. (eurekalert.org)
• If adverse effects occur, the dose is decreased and another drug is added. (vin.com)
• More broadly, this partnership is evidence of increasing interest, among both regulators and pharmaceutical manufacturers, in the value of social media as a tool to identify potential adverse drug reactions and safety issues. (ebglaw.com)
• Those approvals typically come with postmarketing requirements, indicating that the drug will be closely watched once it hits the market, to see whether any serious adverse drug side effects begin appearing among its users. (aboutlawsuits.com)
• After pharmacotherapy is implemented, periodic laboratory tests may be required to monitor drug levels and to ensure that no adverse response to the medication is harming renal or hepatic function or bone marrow. (medscape.com)
• Adverse Drug React Toxicol Rev. 1997;16(3):133-170. (cdc.gov)

Biological4

• The researchers were able to collect biological data from the devices, such as what molecular changes happened when each drug was administered. (yahoo.com)
• Therapeutic drug monitoring (TDM) refers to the quantitative measurement of drugs in serum/plasma (or other biological fluids). (vin.com)
• In addition, checkpoint inhibitors are more frequently being employed in combination with other agents (including with other checkpoint inhibitors) in clinical practice, as well in hundreds of combination drug trials with other novel biological, targeted, and immunotherapies. (degruyter.com)
• Biological monitoring of cyclophosphamide and ifosfamide in urine of hospital personnel occupationally exposed to cytostatic drugs. (bmj.com)

Pharmacokinetic1

• of the patient, the dosage regimen used, the pharmacokinetic characteristics of the drug, and other covariables (e.g., plasma potassium and ECG for digoxin). (vin.com)

Alcohol6

• Monitoring of commercial pilots with alcohol and drug issues will be improved with two new measures announced today by Associate Transport Minister Nathan Guy. (nbr.co.nz)
• I'm confident that airlines take the issue of drug and alcohol abuse seriously, and that the vast majority of pilots do an outstanding job,' Mr Guy said. (nbr.co.nz)
• The CAA believed alcohol abuse and recreational drug use for pilots was 'well below' that of the general population and comparable with other nations. (nbr.co.nz)
• These include direct myotoxicity (caused by alcohol, cocaine, glucocorticoids, and statins, amongst others), immunologically-induced inflammatory myopathy (caused by D-penicillamine, statins, and anti-cancer drugs), and indirect SKM injury (occurs as a result of a variety of different mechanisms). (degruyter.com)
• The Rest of the Story: Tobacco and Alcohol News Analysis and Commentary: If Physicians Prescribing a Drug Need to Monitor Those Patients for Death, What Business Does the FDA Have Approving that Drug? (blogspot.com)
• Initial tests for substance and alcohol abuse are usually necessary to exclude drugs and alcohol as causative agents for behavior. (medscape.com)

Diversion2

• The pharmacist is the last line of defense to check the red flags for prescription drug abuse and diversion," said lead investigator Connor Norwood, MHA, from the Indiana University School of Medicine in Indianapolis. (medscape.com)
• This course will provide information pertaining to the history and development of the Arkansas Prescription Drug Monitoring Program (PDMP) and the state statutes allowing law enforcement access, prescription drug division, and conducting drug diversion investigations as well as an overall understanding of prescription drug abuse issues and the PDMP. (cji.edu)

Prescription drug18

• A prescription drug monitoring program (PDMP) is an electronic database that tracks controlled substance prescriptions . (cdc.gov)
• CHICAGO - Pharmacists in Indiana are three times more likely to refuse to dispense a controlled substance when they use the state prescription drug monitoring program than when they don't, results from a new survey show. (medscape.com)
• It is also important to know if the refusals were valid, because a prescription drug monitoring program can contain errors, he said. (medscape.com)
• Prescription drug monitoring programs are not a magic bullet," Dr Hagemeier he told Medscape Medical News . (medscape.com)
• They alone are not going to solve the problem of prescription drug abuse. (medscape.com)
• Everyone has to take ownership of the problem of prescription drug abuse. (medscape.com)
• Norwood said he agrees that prescription drug monitoring programs are not the only tool clinicians should use to prevent the abuse of prescription drugs, but noted that many healthcare providers are not using these programs at all. (medscape.com)
• Prescription drug abuse is at a crisis level in Pennsylvania. (sciencedaily.com)
• In this story, the history of the crisis and the long political path the Commonwealth took to build a prescription drug monitoring system for physician use is examined. (sciencedaily.com)
• Today, it's a well-known fact that prescription drug abuse is a public health crisis across the country. (sciencedaily.com)
• In Pennsylvania, few took notice to the silent epidemic before deaths from prescription drug abuse started making the front pages of newspapers across the state. (sciencedaily.com)
• bullet" Eric Sterling notes that the story of increased prescription drug use should include better warnings about drug interactions with common dangerous drugs like acetaminophen (which, unlike illegal drugs like marijuana, has serious risk of fatality in certain interactions). (drugwarrant.com)
• bullet" Alex at the Drug Law Blog points out that increased prohibition is likely to drive teens to the more risky prescription drug experimentation. (drugwarrant.com)
• GAO found plan sponsors-private companies that provide voluntary Medicare Part D prescription drug coverage-received $48.6 billion in rebates from drug manufacturers in 2021. (gao.gov)
• Whichever side you come down on it is clear that Florida is serious about cracking down on prescription drug abuse. (mosesandrooth.com)
• Law enforcement now has the ability to expand their investigations into prescription drug fraud. (mosesandrooth.com)
• Title : Academic Detailing Increases Prescription Drug Monitoring Program Use Among Primary Care Practices Personal Author(s) : Ball, Sarah J.;McCauley, Jenna A.;Pruitt, Megan;Zhang, Jingwen;Marsden, Justin;Barth, Kelly S.;Mauldin, Patrick D.;Gebregziabher, Mulugeta;Moran, William P. (cdc.gov)
• The Prescription Drug Monitoring Program Training and Technical Assistance Center (PDMP TTAC) reports 2020 data and 2021 features of the West Virginia state Prescription Drug Monitoring Program (PDMP). (ojp.gov)

Results7

• According to their results, therapeutic drug monitoring was not superior to standard treatment for achieving disease remission at 30 weeks in people with a range of rheumatic diseases. (eurekalert.org)
• We feel that our results put to rest a long-standing debate on the merits of using therapeutic drug monitoring in all patients starting TNFi. (eurekalert.org)
• We report the 18F-FDG PET/CT results for monitoring response to TKI and alkylating drugs in a patient with refractory SDHB-deficient GIST. (nih.gov)
• NIDA Director Dr. Nora Volkow discusses results of the 2020 Monitoring the Future Survey, with some vaping of nicotine and marijuana stabilizing, but the use of amphetamines and inhalants increasing among eighth graders. (nih.gov)
• At the end of a year that has seen further tragic deaths from addiction and new designer drugs that put young people at risk, today's results from the 2014 Monitoring the Future (MTF) survey of drug use among adolescents provide a dose of welcome optimism. (drugprevent.org.uk)
• Our aim was to evaluate the clinical efficacy, drug sustainability, frequency of dose intensification, and results from therapeutic drug monitoring in UST treated Crohn's disease (CD) patients using a prospective, nationwide, multicenter cohort from Hungary. (ecco-ibd.eu)
• The results of monitoring with the mobile unit led to a change in management in 34 patients, including the insertion of five pacemakers and two implantable cardioverter defibrillators, noted Joshi. (medscape.com)

Children and adolescents3

• Describes community systems that monitor the well-being of children and adolescents and lists recommendations that define the next steps for creating and mentoring effective community monitoring systems. (unt.edu)
• The charts help clinicians to define obesity and monitor growth in children and adolescents. (cdc.gov)
• The new report compares and evaluates different methods for adding curves to the BMI-for-age growth charts to help clinicians and researchers better monitor growth in children and adolescents with very high BMI. (cdc.gov)

Overdose deaths1

• According to a DEA Intelligence Report, York County had 118 drug-related overdose deaths in 2014, nearly double any neighboring county. (sciencedaily.com)

Indications1

• These recommendations do not represent approval by the Food and Drug Administration (FDA) or approved labeling for the particular products or indications in question. (cdc.gov)

Clinical20

• This personalized monitoring can be time-consuming and costly, and it is unclear whether it actually improves clinical outcomes. (eurekalert.org)
• Despite a lack of clinical trial data and diverging guidelines, proactive therapeutic drug monitoring has already been adopted in clinical practice across different specialities. (eurekalert.org)
• This study highlights the need for thorough evaluation of monitoring tools and treatment strategies before their implementation in clinical care," says Dr. Syversen. (eurekalert.org)
• Future research should explore if more targeted applications of therapeutic drug monitoring, such as assessment of serum drug levels in treatment failures, could be a useful clinical tool, she adds. (eurekalert.org)
• Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication levels in blood. (wikipedia.org)
• TDM aimed at improving patient care by individually adjusting the dose of drugs for which clinical experience or clinical trials have shown it improved outcome in the general or special populations. (wikipedia.org)
• In pharmacotherapy, many medications are used without monitoring of blood levels, as their dosage can generally be varied according to the clinical response that a patient gets to that substance. (wikipedia.org)
• TDM is particularly helpful for drugs with a narrow therapeutic index, large inter- and intraindividual variability in pharmacokinetics and therapeutic response, when treatment fails on standard dosing, when the therapeutic effect is difficult to monitor, or when the drug is used to prevent the occurrence of clinical signs (e.g., anti-epileptic and anti-arrhythmic drugs). (vin.com)
• CMS conducts an annual clinical formulary review, which includes reviewing if formularies include commonly prescribed drug classes. (gao.gov)
• CMS officials told GAO that an evaluation of rebate information is unnecessary given its clinical formulary review, and that CMS is statutorily prohibited from interfering with drug manufacturer and plan sponsor negotiations. (gao.gov)
• The clinical picture of drug-induced myopathies may be highly variable. (degruyter.com)
• Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. (degruyter.com)
• This can be incredibly useful in both clinical practice and for de-challenge/re-challenge investigational trials where the risk of drug-induced SKM injury is present. (degruyter.com)
• The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)
• In clinical practice, as well as during drug development and in clinical trials, the diagnosis of SKM injury can be challenging due to the variable symptomology, reliance on patient-self reporting, and lack of highly specific biomarkers, such as those available for cardiac myocyte injury (i.e., cardiac troponins) [ 3 ]. (degruyter.com)
• Drug discovery is an expensive process and only ~ 10% of all drugs in Phase 1 clinical trial gain regulatory approval by the US Food and Drug Administration (FDA), with oncology drugs having the lowest likelihood of success. (stanford.edu)
• Data from patient demographics, disease phenotype, treatment history (surgical history, prior and present medical therapies), clinical disease activity (using the Crohn's Disease Activity Index (CDAI), Harvey Bradshaw Index (HBI)), biomarkers (C-reactive protein - CRP), and therapeutic drug monitoring were captured. (ecco-ibd.eu)
• Ustekinumab showed good drug sustainability and clinical efficacy in a population with severe disease phenotype and high rates of previous anti-TNF failure, however frequent and early dose intensification was required. (ecco-ibd.eu)
• After development of a multi-analyte assay protocol, plasma samples (n = 743) from a multi-center cluster-randomized clinical trial (n = 12 sites) of an hazardous drug educational intervention were assayed. (cdc.gov)
• Clinical experience with intravenous zanamivir under an emergency investigational new drug program in the United States. (cdc.gov)

Marijuana2

• And although synthetic cannabinoids like "K2" and "Spice" (also known as "synthetic marijuana") have only been tracked in the survey for the past two years for all three grades, use of these very dangerous and unpredictable drugs is also down from last year. (drugprevent.org.uk)
• With the collaboration of other NIH institutes, NIDA is planning a major longitudinal study that will examine the effects of teen marijuana and other drug use more closely over the next decade. (drugprevent.org.uk)

Prescribing1

• If Physicians Prescribing a Drug Need to Monitor Those Patients for Death, What Business Does the FDA Have Approving that Drug? (blogspot.com)

Constantly1

• Their heart rhythm is being monitored constantly. (medscape.com)

Interactions1

• The use of checkpoint inhibitors in combination therapy further complicates the safety monitoring of SKM injury due to the potential for drug-drug interactions. (degruyter.com)

Tumors3

• It can observe the impact of up to 20 drugs on the market for cancerous tumors, according to the researchers. (yahoo.com)
• published Wednesday, Pierpaolo Peruzzi, co-principal investigator and assistant professor in the Department of Neurosurgery at Brigham and Women's Hospital said that knowing the impact of cancer drugs on these tumors is critical. (yahoo.com)
• Typically, pharmacokinetics data are derived from blood measurements of circulating drug concentrations, but such method does not capture drug absorption within tumors. (stanford.edu)

Biologic1

• They are part of a class of drugs called biologic disease-modifying anti-rheumatic drugs, or biologics. (eurekalert.org)

Measurement of drug2

• As a result, we can achieve to collect in situ tumor-specific pharmacokinetics data that account for tissue heterogeneity within a single animal, which is the first demonstration of continuous and multi-site measurement of drug within tumor of a live animal. (stanford.edu)
• TDM is the measurement of drug levels in blood. (saladax.com)

Detect4

• TDM determinations are also used to detect and diagnose poisoning with drugs, should the suspicion arise. (wikipedia.org)
• The work presented here outlines an analytical platform that utilizes ambient ionization mass spectrometry and additional techniques (e.g., tandem mass spectrometry) to analyze trace residues from drug paraphernalia to quickly detect both drugs and cutting agents. (nist.gov)
• Placing the antibody within the biosensor has led to a pipeline of biosensors that can detect numerous drugs in blood samples. (pharmacytimes.com)
• Since it is possible to detect most compounds ingested in a defined timeframe prior to sampling, hair analysis allows for a re-creation of the drug exposure history. (europa.eu)

Exposure4

• The concept of a posteriori TDM corresponds to the usual meaning of TDM in medical practice, which refers to the readjustment of the dosage of a given treatment in response to the measurement of an appropriate marker of drug exposure or effect. (wikipedia.org)
• The message should be clear and unequivocal: For teens and young adults, whose brains are still not finished maturing and thus can be readily altered in their development by any substance exposure, there are simply no safe drugs. (drugprevent.org.uk)
• The occupational exposure of 21 nurses and pharmacy personnel from eight hospitals to cyclophosphamide and ifosfamide was determined by quantifying the amount of the drugs handled and by measuring the urinary excretion of the unmetabolised substances. (bmj.com)
• Objectives: Despite safe handling guidelines published by several groups, health care worker exposure to hazardous drugs continues to occur due to suboptimal engineering control s and low use of protective equipment. (cdc.gov)

Experimentation1

• It is hard to predict, because a lot of drug experimentation is peer pressure. (nih.gov)

Main3

• Its main focus is on drugs with a narrow therapeutic range, i.e. drugs that can easily be under- or overdosed. (wikipedia.org)
• The main utility of these two methods is to obtain the impulse response of drug tablet alone by separating the transducer response from the tablet response. (controleng.com)
• Interior Minister Abdolreza Rahmani-Fazli said May 18, "The discussion of punishing smugglers and punishment's influence on the activities of drug smugglers is one of the main issues being discussed by the Iran Drug Control Headquarters. (al-monitor.com)

Deaths1

• According to York County Coroner Pam Gay, 2015 is likely to be similar to 2014 with its end of year statistics of 65 heroin-related deaths out of 95 drug deaths overall (with a few still pending). (sciencedaily.com)

Medications2

• My daughter is a young adult, yet I still monitor her medications. (healthyplace.com)
• The findings are similar to warnings issued in a report released by the Institute of Medicine of the National Academies in 2012, which found that the agency's current approach to drug oversight after medications are approved is not sufficient and does not ensure that the benefits and risks of drugs are consistently monitored over the life cycle of the product. (aboutlawsuits.com)

Assessment2

• The focus is on planning and implementing a transmission assessment survey as an input to decide whether to move from mass drug administration (MDA) to post-MDA surveillance. (who.int)
• However, it is difficult to extrapolate overall drug penetration in the heterogeneous tumor tissue environment from a single sampling site, and this in turn leads to inaccurate PK assessment,' says Seo. (stanford.edu)

Patients22

• ATLANTA -- New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care. (eurekalert.org)
• TNFi drugs may help patients lower their disease activity, relieve debilitating symptoms, and manage their condition long term. (eurekalert.org)
• Some patients experience a lack or loss of response to TNFi, possibly due to low serum drug levels and or the formation of anti-drug antibodies. (eurekalert.org)
• Patients were randomly assigned to receive infliximab either with or without therapeutic drug monitoring. (eurekalert.org)
• The researchers included 198 patients in the therapeutic drug monitoring arm and 200 patients were included in the control group. (eurekalert.org)
• In the study's therapeutic drug monitoring arm, 100 or 53% of patients achieved remission, while 106 or 54% of the patients in the standard treatment group also achieved remission. (eurekalert.org)
• The study also found that 10% of patients who had therapeutic drug monitoring and 15% of patients receiving standard treatment developed significant levels of anti-drug antibodies. (eurekalert.org)
• It identifies patients who have multiple providers for prescription drugs, such as painkillers, which is an indication of "doctor shopping. (medscape.com)
• We wanted (patients) to swallow a chemical and have it transform into something else that's easy to monitor," said Matthew Booth, an assistant professor of anesthesiology at the UF College of Medicine and an investigator in the study. (medgadget.com)
• This method allows patients to monitor the information themselves without undergoing tests in a laboratory. (pharmacytimes.com)
• The Government Accountability Office (GAO) issued a report on drug safety (PDF) last month, determining that the FDA was approving too many drugs via fast-track approval processes and then failing to monitor those drugs' effects on patients to ensure they are actually safe. (aboutlawsuits.com)
• Today, the Rest of the Story is questioning the wisdom of keeping a drug on the market when its required black box warning admonishes doctors to observe their patients for death. (blogspot.com)
• Physicians are instructed by the FDA to monitor their patients for attempted suicide, which is of course, in some cases, successful. (blogspot.com)
• In other words, doctors are being told that a significant possible side effect of the medication is death and that it behooves them to monitor their patients to see if they die from the drug. (blogspot.com)
• But most importantly, I don't see how the FDA can keep a drug on the market when it feels compelled to warn physicians that they need to carefully monitor their patients for possible death. (blogspot.com)
• Drug sustainability was high with 81.9% (SD: 3.4) of patients remaining on treatment at one year. (ecco-ibd.eu)
• Numerous studies have shown that this method is inaccurate with respect to drug dosing and leads to wide variability of drug levels in patients. (saladax.com)
• Wynnewood, PA - Early experiences with an ambulatory electrocardiographic monitoring system have shown the device to be effective at detecting cardiac arrhythmias in patients with and without symptoms. (medscape.com)
• You effectively have monitoring that is as close as patients receive in the hospital but lets them go about their daily lives in the community. (medscape.com)
• The duration of monitoring was determined individually for each patient, with patients using the system an average of 9.9 days. (medscape.com)
• He noted that 30 patients had been previously monitored with a Holter monitor or event recorder. (medscape.com)
• In 16 of these patients, MCOT detected an arrhythmia not picked up by the previous monitoring system. (medscape.com)

Program3

• In January 2019, the MHS entered an agreement with the National Association of Boards of Pharmacy (NABP) to establish a connection with their Prescription Monitoring Program (PMP) Interconnect ® SystemNABP PMP InterConnect , which allows for the transfer of prescription data across state lines. (health.mil)
• Those in opposition, including Gov. Scott prior to changing his mind, believe that the monitoring program violates patient privacy. (mosesandrooth.com)
• In all, about a quarter of drugs approved from October 2006 to December 2014 used some form of expedited program, the report indicates. (aboutlawsuits.com)

19962

• In mid-February 2016, Modern Healthcare took a closer look at the root of the problem and traces it back to 1996 when Purdue Pharma began promoting a new drug to fight pain -- OxyContin. (sciencedaily.com)
• European Monitoring Centre for Drugs and Drug Addiction (EMCDDA): general report of activities 1996. (drugsandalcohol.ie)

Optimize2

• Therapeutic drug monitoring is one proposed strategy to prevent loss of response and to optimize TNFi effectiveness. (eurekalert.org)
• Because failure to properly carry out any one of the components can severely affect the usefulness of using drug concentrations to optimize therapy, an organized approach to the overall process is critical. (wikipedia.org)

Antifungal1

• An improved understanding of antifungal pharmacology and antifungal pharmacokinetics-pharmacodynamics has resulted in therapeutic drug monitoring (TDM) becoming a valuable adjunct to the routine administration of some antifungal agents. (nih.gov)

Dose of drug1

• TDM is the process of using a blood level test to determine if the optimal dose of drug is given to a patient. (saladax.com)

America2

• People who believe in a drug-free America need to be placed in padded protective custody where they can't hurt anybody and where they can have extended conversations with the reincarnation of Napoleon Bonaparte about the dragons lurking at the edge of the world. (drugwarrant.com)
• WASHINGTON, United States of America - July 2014 Through a cooperation with the University of Maryland's Center for Substance Abuse Research (CESAR), the National Drug Early Warning System (NDEWS) will be the first American national public health surveillance system with the ability to identify emerging drug trends and quickly disseminate information to the public using traditional and social media, websites, publications and newsletters. (unodc.org)

Enforcement4

• Current analytical techniques are limited in their abilities to rapidly identify drugs that would inform both public health and law enforcement officials about the evolving drug landscape. (nist.gov)
• NDA head of enforcement Samuel Kyomukama told journalists that they have impounded over 303 boxes of drugs corresponding to the amount above. (monitor.co.ug)
• Advocates contend that it gives law enforcement the ability to monitor "pill mills" and is necessary to combat Florida's growing prescription pill epidemic. (mosesandrooth.com)
• Law enforcement at the Federal, State, and local level has made it clear that they are targeting the unlawful possession of prescription medication and those that obtain these drugs fraudulently. (mosesandrooth.com)

Serum1

• Most drugs are bound to serum proteins to various extents, and only free drug is pharmacologically active. (vin.com)

Biomarkers2

• Therefore, the present study proposes a strategy for drug safety monitoring using the available biomarkers of SKM injury. (degruyter.com)
• Moreover, we will discuss mechanisms of drug-induced SKM injury, traditional laboratory testing for SKM injury, and novel skeletal myocyte biomarkers under investigation. (degruyter.com)

Addiction2

• The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) is the reference point on drugs and drug addiction information in Europe. (europa.eu)
• European Monitoring Centre for Drugs and Drug Addiction. (drugsandalcohol.ie)

Investigators4

• A group of investigators have created novel antibody-based biosensors that monitor drug concentrations in the blood. (pharmacytimes.com)
• FDA has supported efforts to shorten development and streamline the agency's review of drug applications through expedited pathways," GAO investigators noted. (aboutlawsuits.com)
• [ 1 ] The remote system appears to be highly sensitive, detecting arrhythmias not picked up by previous monitoring, and capable of obtaining "high-quality" ECG readings, report investigators. (medscape.com)
• Publishing their early experiences with the mobile cardiac outpatient telemetry system, known as MCOT (CardioNet, San Diego, CA), in the April 2005 issue of the American Journal of Cardiology , the investigators write that "compared with Holter monitoring and external loop recorders, MCOT increases the sensitivity of detecting atrial fibrillation without symptoms by providing a longer period of monitoring and without the need for patient activation. (medscape.com)

Levels1

• Therefore, blood plasma pharmacokinetics data is not a good reflection of intra-tumoral drug levels. (stanford.edu)

Crisis2

• The Jordanian and Iranian foreign ministers met to discuss the Syrian crisis last week, as the conflict continues to rage on and cross-border drug smuggling plagues the region. (middleeastmonitor.com)
• He "stressed the need to stop the threats the crisis poses to the security of Jordan and the region, especially the threat of drug trafficking," according to an Iranian readout. (middleeastmonitor.com)

Officials4

• The Centers for Medicare & Medicaid Services (CMS) uses drug rebate data to help ensure its plan sponsor payments are accurate, but CMS officials stated they do not use this data in its oversight of plan formularies. (gao.gov)
• When a drug like xylazine is detected in sewers, officials can alert doctors, substance use counselors and treatment programs. (wusf.org)
• Mohammad Javad Larijani, the secretary of Iran's Human Rights Council, has been joined by other officials in his repeated calls to cut down on executions for drug offenses. (al-monitor.com)
• Rahmani-Fazli, who is also the secretary of that organization, added that there will be meetings with judiciary officials, including the head of the judiciary, to form a joint committee headed by the attorney general to review methods for punishing drug convictions . (al-monitor.com)

Therapeutics2

• The Self-Monitoring And Reporting Therapeutics (SMART™) monitor used in the HIV/AIDS trial is from Gainesville, FL-based Xhale , Inc, which says that its technology "enables the creation of a breath-detectable version of any pharmaceutical drug. (medgadget.com)
• Diabetes monitoring and therapeutics to manage the disease and its complications continues to be an attractive market for many manufacturers. (kaloramainformation.com)

Data16

• For some reason, I just can't get too excited about the release of the new Monitoring the Future data. (drugwarrant.com)
• Here's three things I'd like to see to get a real picture of teens and drug problems (and only one could be accomplished within the current structure of Monitoring the Future data). (drugwarrant.com)
• Explore the most recent data on the drug situation in Europe provided by the EU Member States. (europa.eu)
• However, monitoring rebate and expenditure data would not require CMS to interfere with negotiations between plan sponsors and manufacturers, and it could provide CMS and Congress insight on the extent to which rebates' influence on formularies could discourage enrollment of certain beneficiaries. (gao.gov)
• MCCLURG: He says data collected during the pandemic illustrated that the drugs of choice changed. (wusf.org)
• We have to be aware that the data that we generated this year on Monitoring the Future was completed before the close down due to COVID. (nih.gov)
• So, we will need to get the data to actually know, ultimately, how the COVID pandemic has affected use of drugs among teenagers in our country. (nih.gov)
• However, evaluations conducted by CDER (Center for Drug Evaluation and Research) of data in its database revealed problems with the completeness, timeliness, and accuracy of the data. (aboutlawsuits.com)
• Worse drugs and medical devices have been approved by the FDA with PMA (pre-marketing approval) the data submitted by the manufacturers for such approvals wasn't properly verified, sometimes not at all. (aboutlawsuits.com)
• The Monitored Drugs List, updates, and the XML Data Extract , are available for download from the links below. (gov.on.ca)
• While overall the MTF data this year are encouraging, we of course cannot relax our efforts in educating teens about the dangers of the drugs they encounter now and will continue to encounter as they grow older. (drugprevent.org.uk)
• There are also multiple microelectrodes to collect data on drug concentrations in different tumor regions. (stanford.edu)
• Importantly, as the aptamer can reversibly bind and release its drug target, the sensor can continually collect pharmacokinetics data. (stanford.edu)
• The publication is a rigorous examination of the literature data on the benefits of 5-FU therapeutic drug monitoring (TDM). (saladax.com)
• In the home, the monitor can be set up by a technician to receive data from the sensor from a distance of 30 feet or carried in a briefcase or in a pocket when the patient is ambulatory. (medscape.com)
• One feature of the system is the automatic transmission of any detected arrhythmia, transmitted via the built-in wireless network, to a central monitoring station where the rhythm data can be analyzed and forwarded directly to the attending physician. (medscape.com)

Device3

• The device is designed to only remain implanted in a patient for about two to three hours while it delivers microdoses of the respective drug that is under observation. (yahoo.com)
• New skin patch technology, based on stretchable electronics, nanomembranes, and nanoparticles, developed by scientists in Korea and U.S., has the potential to provide continuous movement monitoring and drug delivery in a device the size of a bandage. (medgadget.com)
• Using a microfluidic device, the digestion of lipid systems may be monitored with far better control over the mixing of the components and the application of enzyme, thereby elucidating a finer understanding of the structural progression of these lipid systems. (rsc.org)

Food and Drug Admin1

• The additive, called 2-butanol, is one of many GRAS - Generally Recognized as Safe - compounds approved by the Food and Drug Administration for use in foods. (medgadget.com)