A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Drugs used to prevent NAUSEA or VOMITING.
Emesis and queasiness occurring after anesthesia.
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
A form of analgesia accompanied by general quiescence and psychic indifference to environmental stimuli, without loss of consciousness, and produced by the combined administration of a major tranquilizer (neuroleptic) and a narcotic.
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
A dopamine D2 antagonist that is used as an antiemetic.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter.
Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
Compounds containing phenyl-1-butanone.

Preproopiomelanocortin and preprodynorphin mRNA expressions in rat brain after electroacupuncture + droperidol. (1/100)

AIM: To study the expression of preproopiomelanocortin (POMC) and preprodynorphin (PPD) mRNA following the combination of electroacupuncture (EA) with droperidol (Dro), a dopamine receptor antagonist. METHODS: The brains and spinal cords of Sprague-Dawley rats were sectioned after combination of EA with Dro, and the gene expression was investigated using nonradioactive in situ hybridization histochemistry (ISHH). RESULTS: Ten hours after EA, the POMC mRNA expression was enhanced; the expression was further enhanced when EA was combined with Dro. The expression of PPD mRNA showed regional difference in central nervous system (CNS): in spinal cord, EA enhanced the PPD mRNA expression and the combination of EA with Dro further promoted the expression; in the brain, the PPD mRNA expression after EA or combination of EA with Dro showed no obvious change in most regions (caudate-putamen, accumbens, arcuate nucleus of hypothalamus) or was decreased in supraoptic nucleus. CONCLUSION: Dro combined with EA promoted the expression of POMC mRNA in CNS and PPD mRNA in spinal cord, but reduced or had no effect on PPD mRNA expression in the brain.  (+info)

Ondansetron and droperidol in the prevention of postoperative nausea and vomiting. (2/100)

We have performed a prospective, randomized, double-blind clinical study to assess the efficacy of ondansetron, droperidol, or both, in preventing postoperative emesis. We studied 242 patients undergoing biliary or gynaecological surgery under general anaesthesia. Shortly before induction of anaesthesia, patients received: saline i.v. (group I, n = 62); droperidol 2.5 mg i.v. (group 2, n = 60); ondansetron 4 mg i.v. (group 3, n = 57); or droperidol 2.5 mg with ondansetron 4 mg i.v. (group 4, n = 63). Nausea occurred in 45%, 37%, 32% and 29% (P = 0.234) and vomiting in 23%, 17%, 9% and 5% (P = 0.016) of patients in groups 1, 2, 3 and 4, respectively, during the first 24 h. Groups 2 and 4 had greater sedation scores than group 1 during the first 3 h (P < 0.01). We conclude that both droperidol and ondansetron showed a significant antiemetic effect, ondansetron was not significantly better than droperidol, and the combination of droperidol and ondansetron was better than droperidol but no better than ondansetron alone.  (+info)

Cost-effectiveness of prophylactic antiemetic therapy with ondansetron, droperidol, or placebo. (3/100)

BACKGROUND: In an era of growing economic constraints on healthcare delivery, anesthesiologists are increasingly expected to understand cost analysis and evaluate clinical practices. Postoperative nausea and vomiting (PONV) are distressing for patients and may increase costs in an ambulatory surgical unit. The authors compared the cost-effectiveness of four prophylactic intravenous regimens for PONV: 4 mg ondansetron, 0.625 mg droperidol, 1.25 mg droperidol, and placebo. METHODS: Adult surgical outpatients at high risk for PONV were studied. Study drugs were administered intravenously within 20 min of induction of nitrous oxide-isoflurane or enflurane anesthesia. A decision-tree analysis was used to group patients into 12 mutually exclusive subgroups based on treatment and outcome. Costs were calculated for the prevention and treatment of PONV. Cost-effectiveness analysis was performed for each group. RESULTS: Two thousand sixty-one patients were enrolled. Efficacy data for study drugs have been previously reported, and the database from that study was used for pharmacoeconomic analysis. The mean-median total cost per patient who received prophylactic treatment with 4 mg ondansetron, 0.625 mg droperidol, 1.25 mg droperidol, and placebo were $112 or $16.44, $109 or $0.63, $104 or $0.51, and $164 or $51.20, respectively (P = 0.001, active treatment groups vs. placebo). The use of a prophylactic antiemetic agent significantly increased patient satisfaction (P < 0.05). Personnel costs in managing PONV and unexpected hospital admission constitute major cost components in our analysis. Exclusion of nursing labor costs from the calculation did not alter the overall conclusions regarding the relative costs of antiemetic therapy. CONCLUSION: The use of prophylactic antiemetic therapy in high-risk ambulatory surgical patients was more effective in preventing PONV and achieved greater patient satisfaction at a lower cost compared with placebo. The use of 1.25 mg droperidol intravenously was associated with greater effectiveness, lower costs, and similar patient satisfaction compared with 0.625 mg droperidol intravenously and 4 mg ondansetron intravenously.  (+info)

Differential block of fast and slow inactivating tetrodotoxin-sensitive sodium channels by droperidol in spinal dorsal horn neurons. (4/100)

BACKGROUND: Dorsal horn neurons of the spinal cord participate in neuronal pain transmission. During spinal and epidural anesthesia, dorsal horn neurons are exposed to local anesthetics and opioids. Droperidol is usually given with opioids to avoid nausea and vomiting. A recently developed method of "entire soma isolation" has made it possible to study directly the action of droperidol on different components of Na+ current in dorsal horn neurons. METHODS: Using a combination of the whole-cell patch-clamp recording from spinal cord slices and the entire soma isolation method, we studied the direct action of droperidol on two types of Na+ currents in dorsal horn neurons of young rats. RESULTS: The tetrodotoxin-sensitive Na+ current in isolated somata consisted of a fast inactivating (tauF, 0.5-2 ms; 80-90% of the total amplitude) and a slow inactivating (tauS, 6-20 ms; 10-20% of the total amplitude) component. Droperidol, at concentrations relevant for spinal and epidural anesthesia, selectively and reversibly suppressed the fast component with a half-maximum inhibiting concentration (IC50) of 8.3 microm. The slow inactivating component was much less sensitive to droperidol; the estimated IC50 value was 809 microm. CONCLUSIONS: Droperidol selectively blocks fast Na+ channels, the fast and slow components of the Na+ current in dorsal horn neurons are carried through pharmacologically distinct types of Na+ channels, and the effects of droperidol differ from those of local anesthetics and tetrodotoxin, which equipotently suppress both components. Droperidol may be suggested as a pharmacologic tool for separation of different types of inactivating tetrodotoxin-sensitive Na+ channel.  (+info)

A comparison of antiemetic efficacy of droperidol alone and in combination with metoclopramide in day surgery anaesthesia. (5/100)

We have studied the antiemetic efficacy of droperidol alone, and in combination with metoclopramide in first trimester termination of pregnancy in day surgery. The aim was to determine whether the addition of metoclopramide could further reduce the incidence of postoperative nausea and vomiting (PONV) but avoid excessive sedation. Group I (control, n = 40) received i.v. droperidol 0.625 mg at induction. Group II (study, n = 40) received i.v. droperidol 0.625 mg and i.v. metoclopramide 10 mg at induction. The incidence of nausea at 1 and 2 hours postoperatively was 23% and 10% in group I, and 5% and nil in group II respectively. The difference in the incidence of nausea was significant at p < 0.05 at one hour but not at two hours postoperatively. No patients vomited. There was no difference in the sedation and pain score between them. We did not observe any significant side effects attributable to either drug. All patients were discharged home within 3 hours. We conclude that in the prevention of PONV, the combination of metoclopramide and droperidol is superior to the use of droperidol alone at one hour but not at two hours postoperatively.  (+info)

Effects of fentanyl and droperidol on canine left ventricular performance. (6/100)

The effects of fentanyl and droperidol on left ventricular performance were evaluated in the neurally intact dog right-heart-bypass preparation under conditions of constant cardiac output, arterial pressure, and heart rate. Fentanyl, .01 and .02 mg/kg body weight, and droperidol, 0.5 mg/kg, did not affect left ventricular performance. However 1.0 mg/kg droperidol caused a significant (P less than .05) increase in left ventricular end-diastolic pressure and a small decrease in maximum left ventricular dP/dt (.05 less than P less than .10). No significant change in myocardial oxygen consumption was observed. This study indicates that large doses of droperidol may depress left ventricular performance and may account for a portion of the hypotension observed after its administration in man. (Key words: Anesthetics, intravenous, fentanyl; Anesthetics; intravenous, droperidol; Heart, function, fentanyl; Heart, function, droperidol.).  (+info)

Hemodynamic and ventilatory responses to fentanyl, fentanyl-droperidol, and nitrous oxide in patients with acquired valvular heart disease. (7/100)

Fentanyl (10 mug/kh) or fentanyl (10 mug/kg) plus droperidol (100 mug/kg) administered intravenously during 20 minutes to adult patients with acquired valvular heart disease produced minimal circulatory changes. The trend during drug infusion was for mean arterial pressure and systemic vascular resistance to decrease, and for cardiac index and stroke volume index to increase without change in heart rate. Central venous pressure increased during drug infusion (P less than 0.05) but decreased to awake levels following controlled ventilation and skeletal-muscle paralysis, probably reflecting thoracoabdominal-muscle rigidity rather than a circulatory response. Hypoventilation during drug infusion necessitated assisted or controlled ventilation, with or without skeletal muscle paralysis, in 14 of 16 patients. Addition of 60 per cent nitrous oxide following fentanyl or fentanyl-droperidol infusion significantly decreased mean arterial pressure, heart rate, and cardiac index. All circulatory changes were similar in direction and extent to those previously found during morphine-nitrous oxide anesthesia. (Key words: Anesthetics, intravenous, fentanyl; Anesthetics, gases, nitrous oxide; Heart, effect of fentanyl, dorperidol, and nitrous oxide.).  (+info)

Suppression of potassium conductance by droperidol has influence on excitability of spinal sensory neurons. (8/100)

BACKGROUND: During spinal and epidural anesthesia with opioids, droperidol is added to prevent nausea and vomiting. The mechanisms of its action on spinal sensory neurons are not well understood. It was previously shown that droperidol selectively blocks a fast component of the Na+ current. The authors studied the action of droperidol on voltage-gated K+ channels and its effect on membrane excitability in spinal dorsal horn neurons of the rat. METHODS: Using a combination of the patch-clamp technique and the "entire soma isolation" method, the action of droperidol on fast-inactivating A-type and delayed-rectifier K+ channels was investigated. Current-clamp recordings from intact sensory neurons in spinal cord slices were performed to study the functional meaning of K+ channel block for neuronal excitability. RESULTS: Droperidol blocked delayed-rectifier K+ currents in isolated somata of dorsal horn neurons with a half-maximum inhibiting concentration of 20.6 microm. The A-type K+ current was insensitive to up to 100 microm droperidol. At droperidol concentrations insufficient for suppression of an action potential, the block of delayed-rectifier K+ channels led to an increase in action potential duration and, as a consequence, to lowering of the discharge frequency in the neuron. CONCLUSIONS: Droperidol blocks delayed-rectifier K+ channels in a concentration range close to that for suppression of Na+ channels. The block of delayed-rectifier K+ channels by droperidol enhances the suppression of activity in spinal sensory neurons at drug concentrations insufficient for complete conduction block.  (+info)

Droperidol is a butyrophenone neuroleptic medication that is primarily used for its antiemetic (anti-nausea and vomiting) properties. It works by blocking dopamine receptors in the brain, which can help to reduce feelings of nausea and vomiting caused by various factors such as chemotherapy, surgery, or motion sickness.

Droperidol is also known for its sedative and anxiolytic (anxiety-reducing) effects, and has been used in the past as a premedication before surgery to help reduce anxiety and produce sedation. However, due to concerns about rare but serious side effects such as QT prolongation (a heart rhythm disorder), droperidol is now less commonly used for this purpose.

Droperidol is available in injectable form and is typically administered by healthcare professionals in a hospital or clinical setting. It should be used with caution and only under the close supervision of a healthcare provider, as it can cause a range of side effects including dizziness, drowsiness, dry mouth, and restlessness. More serious side effects such as seizures, irregular heartbeat, and neuroleptic malignant syndrome (a rare but potentially life-threatening condition characterized by muscle rigidity, fever, and autonomic instability) have also been reported with droperidol use.

Antiemetics are a class of medications that are used to prevent and treat nausea and vomiting. They work by blocking or reducing the activity of dopamine, serotonin, and other neurotransmitters in the brain that can trigger these symptoms. Antiemetics can be prescribed for a variety of conditions, including motion sickness, chemotherapy-induced nausea and vomiting, postoperative nausea and vomiting, and pregnancy-related morning sickness. Some common examples of antiemetic medications include ondansetron (Zofran), promethazine (Phenergan), and metoclopramide (Reglan).

Postoperative nausea and vomiting (PONV) are common complications following surgical procedures. It is defined as nausea, vomiting, or both that occurs within the first 24 hours after surgery. PONV can lead to dehydration, electrolyte imbalances, wound dehiscence, and impaired patient satisfaction. Risk factors for PONV include female gender, non-smoking status, history of motion sickness or PONV, use of opioids, and longer duration of surgery. Preventive measures and treatments include antiemetic medications, fluid therapy, and acupuncture or acupressure.

Ondansetron is a medication that is primarily used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. It is a selective antagonist of 5-HT3 receptors, which are found in the brain and gut and play a role in triggering the vomiting reflex. By blocking these receptors, ondansetron helps to reduce the frequency and severity of nausea and vomiting.

The drug is available in various forms, including tablets, oral solution, and injection, and is typically administered 30 minutes before chemotherapy or surgery, and then every 8 to 12 hours as needed. Common side effects of ondansetron include headache, constipation, and diarrhea.

It's important to note that ondansetron should be used under the supervision of a healthcare provider, and its use may be contraindicated in certain individuals, such as those with a history of allergic reactions to the drug or who have certain heart conditions.

Neuroleptanalgesia is a clinical state produced by the combined use of a neuroleptic (a drug that dampens down the activity of the brain, leading to decreased awareness of one's surroundings and reduced ability to initiate movements) and an analgesic (a pain-relieving drug). This combination results in a state of dissociative analgesia, where the patient remains conscious but detached from their environment, with reduced perception of pain. It has been used in certain medical procedures as an alternative to general anesthesia.

The term 'neurolept' refers to drugs that have a pronounced effect on the nervous system, reducing psychomotor agitation and emotional reactivity. Examples of neuroleptic drugs include phenothiazines (such as chlorpromazine), butyrophenones (such as haloperidol), and diphenylbutylpiperidines (such as pimozide).

Analgesics, on the other hand, are medications that primarily target pain perception pathways in the nervous system. Common examples include opioids (such as morphine or fentanyl) and non-opioid analgesics (such as acetaminophen or ibuprofen).

The combination of neuroleptic and analgesic drugs is used to achieve a balance between pain relief, sedation, and preservation of the patient's ability to communicate and cooperate during medical procedures. However, due to potential side effects such as respiratory depression, neuroleptanalgesia requires careful monitoring and management by anesthesiologists or other trained medical professionals.

An adjuvant in anesthesia refers to a substance or drug that is added to an anesthetic medication to enhance its effects, make it last longer, or improve the overall quality of anesthesia. Adjuvants do not produce analgesia or anesthesia on their own but work synergistically with other anesthetics to achieve better clinical outcomes.

There are several types of adjuvants used in anesthesia, including:

1. Opioids: These are commonly used adjuvants that enhance the analgesic effect of anesthetic drugs. Examples include fentanyl, sufentanil, and remifentanil.
2. Alpha-2 agonists: Drugs like clonidine and dexmedetomidine are used as adjuvants to provide sedation, analgesia, and anxiolysis. They also help reduce the requirement for other anesthetic drugs, thus minimizing side effects.
3. Ketamine: This NMDA receptor antagonist is used as an adjuvant to provide analgesia and amnesia. It can be used in subanesthetic doses to improve the quality of analgesia during general anesthesia or as a sole anesthetic for procedural sedation.
4. Local anesthetics: When used as an adjuvant, local anesthetics can prolong the duration of postoperative analgesia and reduce the requirement for opioids. Examples include bupivacaine, ropivacaine, and lidocaine.
5. Neostigmine: This cholinesterase inhibitor is used as an adjuvant to reverse the neuromuscular blockade produced by non-depolarizing muscle relaxants at the end of surgery.
6. Dexamethasone: A corticosteroid used as an adjuvant to reduce postoperative nausea and vomiting, inflammation, and pain.
7. Magnesium sulfate: This non-competitive NMDA receptor antagonist is used as an adjuvant to provide analgesia, reduce opioid consumption, and provide neuroprotection in certain surgical settings.

The choice of adjuvants depends on the type of surgery, patient factors, and the desired clinical effects.

Metoclopramide is a medication that is primarily used to manage gastrointestinal disorders. It is classified as a dopamine antagonist and a prokinetic agent, which means it works by blocking the action of dopamine, a chemical in the brain that can slow down stomach and intestine function.

The medical definition of Metoclopramide is:
A synthetic congener of procainamide, used as an antiemetic and to increase gastrointestinal motility. It has a antidopaminergic action, binding to D2 receptors in the chemoreceptor trigger zone and stomach, and it may also block 5HT3 receptors at intrapyloric and central levels. Its actions on the gut smooth muscle are mediated via cholinergic muscarinic receptors. (Source: Dorland's Medical Dictionary)

Metoclopramide is commonly used to treat conditions such as gastroesophageal reflux disease (GERD), gastritis, and gastroparesis, which is a condition that affects the normal movement of food through the digestive tract. It can also be used to prevent nausea and vomiting caused by chemotherapy or radiation therapy.

Like any medication, Metoclopramide can have side effects, including drowsiness, restlessness, and muscle spasms. In some cases, it may cause more serious side effects such as tardive dyskinesia, a condition characterized by involuntary movements of the face, tongue, or limbs. It is important to use Metoclopramide only under the supervision of a healthcare provider and to follow their instructions carefully.

Vomiting is defined in medical terms as the forceful expulsion of stomach contents through the mouth. It is a violent, involuntary act that is usually accompanied by strong contractions of the abdominal muscles and retching. The body's vomiting reflex is typically triggered when the brain receives signals from the digestive system that something is amiss.

There are many potential causes of vomiting, including gastrointestinal infections, food poisoning, motion sickness, pregnancy, alcohol consumption, and certain medications or medical conditions. In some cases, vomiting can be a symptom of a more serious underlying condition, such as a brain injury, concussion, or chemical imbalance in the body.

Vomiting is generally not considered a serious medical emergency on its own, but it can lead to dehydration and other complications if left untreated. If vomiting persists for an extended period of time, or if it is accompanied by other concerning symptoms such as severe abdominal pain, fever, or difficulty breathing, it is important to seek medical attention promptly.

Promethazine is an antihistamine and phenothiazine derivative, which is commonly used for its sedative, anti-emetic (prevents vomiting), and anti-allergic properties. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms, and by blocking the action of dopamine, a neurotransmitter in the brain that helps transmit signals.

Promethazine is used to treat various conditions such as allergies, motion sickness, nausea and vomiting, and as a sedative before and after surgery or medical procedures. It may also be used for its calming effects in children with certain behavioral disorders.

Like all medications, promethazine can have side effects, including drowsiness, dry mouth, blurred vision, and dizziness. More serious side effects may include seizures, irregular heartbeat, and difficulty breathing. It is important to follow the instructions of a healthcare provider when taking promethazine and to report any unusual symptoms or side effects promptly.

Ambulatory surgical procedures, also known as outpatient or same-day surgery, refer to medical operations that do not require an overnight hospital stay. These procedures are typically performed in a specialized ambulatory surgery center (ASC) or in a hospital-based outpatient department. Patients undergoing ambulatory surgical procedures receive anesthesia, undergo the operation, and recover enough to be discharged home on the same day of the procedure.

Examples of common ambulatory surgical procedures include:

1. Arthroscopy (joint scope examination and repair)
2. Cataract surgery
3. Colonoscopy and upper endoscopy
4. Dental surgery, such as wisdom tooth extraction
5. Gallbladder removal (cholecystectomy)
6. Hernia repair
7. Hysteroscopy (examination of the uterus)
8. Minor skin procedures, like biopsies and lesion removals
9. Orthopedic procedures, such as carpal tunnel release or joint injections
10. Pain management procedures, including epidural steroid injections and nerve blocks
11. Podiatric (foot and ankle) surgery
12. Tonsillectomy and adenoidectomy

Advancements in medical technology, minimally invasive surgical techniques, and improved anesthesia methods have contributed to the growth of ambulatory surgical procedures, offering patients a more convenient and cost-effective alternative to traditional inpatient surgeries.

Preanesthetic medication, also known as premedication, refers to the administration of medications before anesthesia to help prepare the patient for the upcoming procedure. These medications can serve various purposes, such as:

1. Anxiolysis: Reducing anxiety and promoting relaxation in patients before surgery.
2. Amnesia: Causing temporary memory loss to help patients forget the events leading up to the surgery.
3. Analgesia: Providing pain relief to minimize discomfort during and after the procedure.
4. Antisialagogue: Decreasing saliva production to reduce the risk of aspiration during intubation.
5. Bronchodilation: Relaxing bronchial smooth muscles, which can help improve respiratory function in patients with obstructive lung diseases.
6. Antiemetic: Preventing or reducing the likelihood of postoperative nausea and vomiting.
7. Sedation: Inducing a state of calmness and drowsiness to facilitate a smooth induction of anesthesia.

Common preanesthetic medications include benzodiazepines (e.g., midazolam), opioids (e.g., fentanyl), anticholinergics (e.g., glycopyrrolate), and H1-antihistamines (e.g., diphenhydramine). The choice of preanesthetic medication depends on the patient's medical history, comorbidities, and the type of anesthesia to be administered.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Psychomotor agitation is a state of increased physical activity and purposeless or semi-purposeful voluntary movements, usually associated with restlessness, irritability, and cognitive impairment. It can be a manifestation of various medical and neurological conditions such as delirium, dementia, bipolar disorder, schizophrenia, and substance withdrawal. Psychomotor agitation may also increase the risk of aggressive behavior and physical harm to oneself or others. Appropriate evaluation and management are necessary to address the underlying cause and alleviate symptoms.

Clonazepam is a medication that belongs to a class of drugs called benzodiazepines. It is primarily used to treat seizure disorders, panic attacks, and anxiety. Clonazepam works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that has a calming effect on the nervous system.

The medication comes in tablet or orally disintegrating tablet form and is typically taken two to three times per day. Common side effects of clonazepam include dizziness, drowsiness, and coordination problems. It can also cause memory problems, mental confusion, and depression.

Like all benzodiazepines, clonazepam has the potential for abuse and addiction, so it should be used with caution and only under the supervision of a healthcare provider. It is important to follow the dosage instructions carefully and not to stop taking the medication suddenly, as this can lead to withdrawal symptoms.

It's important to note that while I strive to provide accurate information, this definition is intended to be a general overview and should not replace professional medical advice. Always consult with a healthcare provider for medical advice.

Butyrophenones are a group of synthetic antipsychotic drugs that are primarily used to treat symptoms of schizophrenia and other psychotic disorders. They act as dopamine receptor antagonists, which means they block the action of dopamine, a neurotransmitter in the brain associated with mood, motivation, and pleasure.

Some examples of butyrophenones include haloperidol, droperidol, and benperidol. These drugs are known for their potent antipsychotic effects and can also be used to manage agitation, aggression, and other behavioral disturbances in patients with various psychiatric and neurological disorders.

In addition to their antipsychotic properties, butyrophenones have been used off-label for their sedative and analgesic effects. However, they are associated with a range of side effects, including extrapyramidal symptoms (EPS), such as involuntary muscle spasms and tremors, as well as other neurological and cardiovascular adverse reactions. Therefore, their use is typically reserved for cases where other treatments have been ineffective or contraindicated.

For treatment of nausea and vomiting, droperidol and ondansetron are equally effective; droperidol is more effective than ... Droperidol is also often used as a rapid sedative in intensive-care treatment, and where "agitation aggression or violent ... QT prolongation is a dose-related effect, and it appears that droperidol is not a significant risk in low doses. A study in ... In 2001, the FDA changed the labeling requirements for droperidol injection to include a Black Box Warning, citing concerns of ...
These images are a random sampling from a Bing search on the term "Droperidol." Click on the image (or right click) to open the ... Multiple studies demonstrated safety of Droperidol and as of 2015 was cleared to return to market in U.S. (available as of 2019 ... Mayo Clinic continued to use Droperidol between 2001 and 2020 without significant adverse events ...
Droperidol is a prescription medication used to treat the symptoms of nausea and vomiting caused by surgery and other medical ... Droperidol has serious interactions with at least 94 other drugs.. *Droperidol has moderate interactions with at least 270 ... Droperidol is a prescription medication used to treat the symptoms of nausea and vomiting caused by surgery and other medical ...
Droperidol injection is used to prevent the nausea and vomiting that may occur after surgery or diagnostic procedures. ...
Droperidol Injection. Products Affected - Description. * *Droperidol injection, Pfizer, 2.5 mg/mL, 2 mL ampule, 10 count, NDC ... Droperidol injection, American Regent, 2.5 mg/mL, 2 mL vial, 25 count, NDC 00517-9702-25 ...
Risk. Risk of environmental impact of droperidol cannot be excluded, due to the lack of environmental toxicity data. ... Environmental information is missing on fass.se for droperidol (2023-05-24). It is voluntary for manufacturers to provide ... Toxicity. It cannot be excluded that droperidol is toxic, due to the lack of data. ... Bioaccumulation. It cannot be excluded that droperidol bioaccumulates, due to the lack of data. ...
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... superiority was not demonstrated for droperidol or ondansetron over placebo. ... Objective: The objective was to separately compare effectiveness of 1.25 mg of intravenous (IV) droperidol and 8 mg of IV ... Randomized Placebo-controlled Trial of Droperidol and Ondansetron for Adult Emergency Department Patients With Nausea Acad ... Conclusion: For adult ED patients with nausea, superiority was not demonstrated for droperidol or ondansetron over placebo. ...
Droperidol is an antiemetic medication used to treat postoperative nausea, vomiting. It is also a sedative and a tranquilizer ... Droperidol: Frequently Asked Questions Answered. What is Droperidol?. Droperidol is a medication that treats and controls ... 1. Is Droperidol used for pain?. Yes, ERs (emergency rooms) and ORs (operation rooms) often use Droperidol for pain relief. It ... 2. Is Droperidol used for nausea?. Yes, Droperidol is a powerful drug that can help treat symptoms of PONV (that is, ...
This study aimed to evaluate the antiemetic benefits and sedation effects of droperidol in morphine-based IV-PCA.Patients who ... There are limited real-world data regarding the use of droperidol for antiemetic prophylaxis in intravenous patient-controlled ... The antiemetic effect of droperidol was significant within 36 h after surgery and attenuated thereafter. Droperidol was ... The addition of droperidol to IV-PCA reduced the risk of PONV without increasing opiate consumption or influencing the level of ...
Find information on Droperidol (Inapsine) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... www.drugguide.com/ddo/view/Davis-Drug-Guide/51248/10.0/droPERidol. Vallerand AHA, Sanoski CAC, Quiring CC. DroPERidol. Daviss ... Vallerand, A. H., Sanoski, C. A., & Quiring, C. (2023). DroPERidol. In Daviss Drug Guide (18th ed.). F.A. Davis Company. https ... TY - ELEC T1 - droPERidol ID - 51248 A1 - Sanoski,Cynthia A, AU - Vallerand,April Hazard, AU - Quiring,Courtney, BT - Daviss ...
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Find information on Droperidol/fentanyl (Innovar) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... "Droperidol/fentanyl." Daviss Drug Guide, 18th ed., F.A. Davis Company, 2023. www.drugguide.com/ddo/view/Davis-Drug-Guide/ ... 109118/all/droperidol_fentanyl. Vallerand AHA, Sanoski CAC, Quiring CC. Droperidol/fentanyl. Daviss Drug Guide. F.A. Davis ... Droperidol/fentanyl [Internet]. In: Daviss Drug Guide. F.A. Davis Company; 2023. [cited 2023 October 02]. Available from: ...
Droperidol kan hæmme virkningen af dopaminagonister. *Droperidol kan forstærke virkningen af sedativer (fx. barbiturater, ... Droperidol kan forstærke opioidbetinget respirationsdepression. *Samtidig indgift af CYP1A2 og/eller CYP3A4-hæmmere kan ... Træk droperidol- og morphin-injektionsvæske op i en injektionssprøjte, og tilsæt isotonisk natriumchlorid-injektionsvæske til ... Patienten bør ikke drikke alkohol 24 timer før eller efter behandling med Droperidol "Sintetica". ...
Researchers found the sedative, droperidol, was a safer and faster option for paramedics to use compared with the ... Droperidol found to act quicker and with fewer side-effects. Date:. May 2, 2018. Source:. Emergency Medicine Foundation ( ... QAS found droperidol sedated patients nearly 70 per cent quicker, was three times safer and significantly fewer patients needed ... The QAS introduced droperidol in 2016 as one of several initiatives to reduce the escalating violence against paramedics, ...
Droperidol, or Olanzapine for Acute Agitation in the ED. An Australian RCT ... Midazolam-Droperidol, Droperidol, or Olanzapine for Acute Agitation in the ED. An Australian RCT 17/2/2017 ... Group 1: Midazolam 5mg + Droperidol 5mg or. Group 2: Droperidol 10mg or. Group 3: Olanzapine 10mg. If patients were not ... Midazolam-Droperidol, Droperidol, or Olanzapine for Acute Agitation: A Randomized Clinical Trial. Ann Emerg Med. 2016 Oct 10. ...
... droperidol (Inapsine); flecainide (Tambocor); haloperidol (Haldol); ipratropium (Atrovent); medications for irritable bowel ...
Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. This medicine may cause serious lung or breathing problems (eg, interstitial lung disease, pneumonitis). Check with your doctor right away if you have chest pain, chills, cough, fever, general feeling of discomfort or illness, thickening of bronchial secretions, or trouble breathing. Check with your doctor right away if blurred vision, dizziness, nervousness, headache, pounding in the ears, or slow or fast heartbeat occurs during or after treatment with this medicine. These can be symptoms of hypertension (high blood pressure). This medicine can cause changes in your heart rhythm, including a condition called QT prolongation. Call your doctor right away if you have dizziness, fainting, or slow, fast, pounding, or uneven heartbeats. This medicine ...
Detailed drug Information for Duo-Vil 2-25. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Detailed drug Information for Toremifene. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Droperidol impurity A. Catalog No: Product Name: Droperidol impurity A. CAS No:2147-83-3,,Chemical Formula:C12H13N3O,,1-(1,2,3, ... Droperidol impurity C. Catalog No: Product Name: Droperidol impurity C. CAS No:60373-76-4,,Chemical Formula:C22H19FN3O2.Cl,,1-[ ... Droperidol impurity B. Catalog No: Product Name: Droperidol impurity B. CAS No:1026015-45-1,,Chemical Formula:C22H22FN3O2,,1-[1 ... Droperidol impurity D. Catalog No: Product Name: Droperidol impurity D. CAS No:466118-75-2,,Chemical Formula:C22H22FN3O3,,(1RS ...
droperidol (Inspsine). *chlorpromazine (Thorazine). First-generation antipsychotics are still used in certain situations. But ...
The effects of CES on droperidol-treated rats were evaluated using the righting reflex latency (RRL) test. CES was shown to ... The authors also observed that CES induced potentiation of inhibition of righting reflex produced by droperidol injection was ... Transcranial electrical stimulation (Limoges currents) potentiates the inhibition of righting reflex induced by droperidol in ... Transcranial electrical stimulation (Limoges currents) potentiates the inhibition of righting reflex induced by droperidol in ...
Existing data on droperidol for management of acute agitation in children suggest that droperidol is both effective and safe ... A Systematic Review of the Effectiveness and Safety of Droperidol for Pediatric Agitation in Acute Care Settings. Shannon C ... droperidol, for the management of acute, severe agitation in children in acute care settings. A systematic review of randomized ... and case series/reports examined the effectiveness and safety of parenteral droperidol for management of acute agitation in ...
Group II (droperidol): 10 μg/kg intravenous droperidol + bilateral P6 sham acupuncture. P6 sham acupuncture is defined as ... P6 Acupoint Injections Are as Effective as Droperidol in Controlling Early Postoperative Nausea and Vomiting in Children Shu- ... acupuncture points, child, droperidol, postoperative anesthesia care unit, postoperative nausea and vomiting, surgical ... The syringe contained either saline (groups I, III, and IV) or 10 μg/kg of droperidol (up to 0.625 mg; group II). The ...
A comparative evaluation of ondansetron, droperidol, and placebo in prevention of postoperative vomiting following ... A comparative evaluation of ondansetron, droperidol, and placebo in prevention of postoperative vomiting following ...
Fluro buterophenones: Haloperidol, Droperidol, Risperidone.. Beta amino ketones: Molindone hydrochloride.. Benzamides: ...

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