Dimethoate
Organophosphate Poisoning
Pralidoxime Compounds
Insecticides
Sri Lanka
Organophosphorus Compounds
Pesticides
Exposure to pesticides in agriculture: a survey of spraymen using dimethoate in the Sudan. (1/20)
There is a need for objective data on the exposure of spraymen to pesticides in agriculture in order to assess minimum requirements for practicable protection in tropical areas. To provide data, a survey was carried out in the Sudan on spraymen using dimethoate. No cholinesterase depressions were found and the calculated dose received by each man per day was within safe limits in the circumstances of this survey. Respiratory exposure was only a minor part of total exposure. The methodology of such surveys is discussed and the need for the use of a standard protocol is emphasized. (+info)Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene. (2/20)
Dimethoate is a widely used organophosphate insecticide that has been shown to disrupt reproductive function in animals. Although the pathogenesis of Dimethoate-induced reproductive toxicity remains to be determined, a reduction in serum testosterone levels is thought to play an important role in the development of Dimethoate-induced infertility. Since Leydig cells play a crucial role in male reproductive function by producing testosterone, the mouse MA-10 Leydig tumor cell line was used to determine if Dimethoate can directly block steroid hormone biosynthesis and to identify the site of steroidogenic inhibition. Dimethoate inhibited steroidogenesis in both a dose- and time-dependent manner without affecting total protein synthesis or protein kinase A activity. While it decreased the activity of the P450 side chain cleavage (P450 scc) enzyme, a reduction in the activity of this enzyme alone could not account for the level of Bu(2)cAMP-inhibited progesterone production. Instead, our results suggest that Dimethoate inhibited steroidogenesis primarily by blocking transcription of the steroidogenic acute regulatory (StAR) gene. This finding is significant since StAR protein mediates the rate-limiting and acutely-regulated step in steroidogenesis, the transfer of cholesterol from the outer to the inner mitochondrial membrane. This study indicates that StAR may be an important target for environmental pollutants which disrupt steroidogenesis and impair reproductive function. (+info)Purification and characterization of a dimethoate-degrading enzyme of Aspergillus niger ZHY256, isolated from sewage. (3/20)
A dimethoate-degrading enzyme from Aspergillus niger ZHY256 was purified to homogeneity with a specific activity of 227.6 U/mg of protein. The molecular mass of the purified enzyme was estimated to be 66 kDa by gel filtration and 67 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The isoelectric point was found to be 5.4, and the enzyme activity was optimal at 50 degrees C and pH 7.0. The activity was inhibited by most of the metal ions and reagents, while it was induced by Cu(2+). The Michaelis constant (K(m)) and V(max) for dimethoate were 1.25 mM and 292 micromol min(-1) mg of protein(-1), respectively. (+info)Gas chromatographic method for assessing the dermal exposure of greenhouse applicators to dimethoate and malathion. (4/20)
An analytical method is developed to determine potential and actual dermal exposure to dimethoate and malathion for agricultural workers using whole body dosimetry. The methodology described includes three different aspects: the validation of the analytical method incorporating a matrix effect for establishing performance parameters such as recovery rates (between 92% and 103% for both pesticides), limits of detection and quantitation, and precision of measurements (RSD < 10%); a field sampling strategy developing a procedure for collecting samples and carrying out field spikes and field blanks in order to ensure the stability of samples during transport, storage, and analysis; and finally, a quality control procedure for ensuring that data are under statistical control. The method is applied to evaluate the potential and actual dermal exposure as well as its distribution for a pesticide applicator and the applicator's assistant after a greenhouse application. Operator exposure levels of approximately 68 mL/h, and 25 mL/h in the case of the assistant, are found. The body areas most exposed are the lower body and hands. (+info)Dimethoate 40% organosphosphorous pesticide toxicity in Prochilodus lineatus (Prochilodontidae, Characiformes) eggs and larvae. (5/20)
Toxicity tests using early life stages of fish are of great importance in assessing risks to growth, reproduction and survival in polluted environments and are important tools for good environmental monitoring. However, a small number of standard bioassays of this type have been developed in Brazil. Curimbata (Prochilodus lineatus) is an abundant South American characid fish of great commercial interest. It was chosen for testing different concentrations of 40% dimethoate, an organophosphate insecticide and acetylcholinesterase enzyme (AChE) inhibitor used widely in Brazil. The 48-h LC50 for eggs is higher than 16.0 microg.L-1, whereas for recently hatched larvae it was found to be significantly lower (11.81 microg.L-1, ranging between 10.23 microg.L-1 - 13.65 microg.L-1) and also significantly lower than that for eggs by a Student t-test for independent samples (p = 0.03). The 96-h LC50 for 3-day old larvae was 10.44 microg.L-1 (8.03 microg.L-1 - 13.57 microg.L-1), similar to that of recently-hatched larvae (p = 0.76). Larval mobility was also found to be reduced by this insecticide. (+info)Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning. (6/20)
(+info)Hypotension in severe dimethoate self-poisoning. (7/20)
(+info)Early-life exposure to dimethoate-induced reproductive toxicity: evaluation of effects on pituitary-testicular axis of mice. (8/20)
(+info)Dimethoate is an organophosphate insecticide and acaricide (a chemical that kills mites). Its chemical formula is C5H12NO3PS. It works by inhibiting the activity of an enzyme called acetylcholinesterase, which is necessary for the proper functioning of the nervous system in both insects and mammals, including humans. This leads to an overstimulation of the nervous system, causing a variety of symptoms such as muscle twitching, tremors, convulsions, and eventually respiratory failure and death in severe cases.
Dimethoate is used to control a wide range of pests, including aphids, thrips, leafminers, and spider mites, on various crops such as fruits, vegetables, cereals, and ornamental plants. However, due to its toxicity to non-target organisms, including humans, it is important to use it with caution and follow all safety guidelines when handling and applying this chemical. It is also subject to regulations regarding its use and disposal in many countries.
Organophosphate (OP) poisoning refers to the toxic effects that occur after exposure to organophosphate compounds, which are commonly used as pesticides, nerve agents, and plasticizers. These substances work by irreversibly inhibiting acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine in the nervous system. As a result, excessive accumulation of acetylcholine leads to overstimulation of cholinergic receptors, causing a wide range of symptoms.
The severity and type of symptoms depend on the dose, duration, and route of exposure (inhalation, ingestion, or skin absorption). The primary manifestations of organophosphate poisoning are:
1. Muscarinic effects: Excess acetylcholine at muscarinic receptors in the parasympathetic nervous system results in symptoms such as narrowed pupils (miosis), increased salivation, lacrimation, sweating, bronchorrhea (excessive respiratory secretions), diarrhea, bradycardia (decreased heart rate), and hypotension.
2. Nicotinic effects: Overstimulation of nicotinic receptors at the neuromuscular junction leads to muscle fasciculations, weakness, and paralysis. This can also cause tachycardia (increased heart rate) and hypertension.
3. Central nervous system effects: OP poisoning may result in headache, dizziness, confusion, seizures, coma, and respiratory depression.
Treatment for organophosphate poisoning includes decontamination, supportive care, and administration of antidotes such as atropine (to block muscarinic effects) and pralidoxime (to reactivate acetylcholinesterase). Delayed treatment can lead to long-term neurological damage or even death.
Pralidoxime compounds are a type of antidote used to treat poisoning from organophosphate nerve agents and pesticides. These compounds work by reactivating the acetylcholinesterase enzyme, which is inhibited by organophosphates. This helps to restore the normal functioning of the nervous system and can save lives in cases of severe poisoning.
Pralidoxime is often used in combination with atropine, another antidote that blocks the effects of excess acetylcholine at muscarinic receptors. Together, these compounds can help to manage the symptoms of organophosphate poisoning and prevent long-term neurological damage.
It is important to note that pralidoxime must be administered as soon as possible after exposure to organophosphates, as its effectiveness decreases over time. This makes rapid diagnosis and treatment crucial in cases of suspected nerve agent or pesticide poisoning.
Insecticides are substances or mixtures of substances intended for preventing, destroying, or mitigating any pest, including insects, arachnids, or other related pests. They can be chemical or biological agents that disrupt the growth, development, or behavior of these organisms, leading to their death or incapacitation. Insecticides are widely used in agriculture, public health, and residential settings for pest control. However, they must be used with caution due to potential risks to non-target organisms and the environment.
I'm sorry for any confusion, but "Sri Lanka" is not a medical term or concept. Sri Lanka is an island country located in the Indian Ocean, south of India. It is known for its diverse landscapes ranging from rainforests and arid plains to highlands and sandy beaches.
If you have any questions related to medicine or healthcare, I would be happy to try and help answer them!
Butyrylcholinesterase (BChE) is an enzyme that catalyzes the hydrolysis of esters of choline, including butyrylcholine and acetylcholine. It is found in various tissues throughout the body, including the liver, brain, and plasma. BChE plays a role in the metabolism of certain drugs and neurotransmitters, and its activity can be inhibited by certain chemicals, such as organophosphate pesticides and nerve agents. Elevated levels of BChE have been found in some neurological disorders, while decreased levels have been associated with genetic deficiencies and liver disease.
Organophosphorus compounds are a class of chemical substances that contain phosphorus bonded to organic compounds. They are used in various applications, including as plasticizers, flame retardants, pesticides (insecticides, herbicides, and nerve gases), and solvents. In medicine, they are also used in the treatment of certain conditions such as glaucoma. However, organophosphorus compounds can be toxic to humans and animals, particularly those that affect the nervous system by inhibiting acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. Exposure to these compounds can cause symptoms such as nausea, vomiting, muscle weakness, and in severe cases, respiratory failure and death.
Pesticides are substances or mixtures of substances intended for preventing, destroying, or repelling pests. Pests can be insects, rodents, fungi, weeds, or other organisms that can cause damage to crops, animals, or humans and their living conditions. The term "pesticide" includes all of the following: insecticides, herbicides, fungicides, rodenticides, bactericides, and various other substances used to control pests.
It is important to note that while pesticides are designed to be toxic to the target pests, they can also pose risks to non-target organisms, including humans, if not used properly. Therefore, it is essential to follow all label instructions and safety precautions when handling and applying pesticides.
Self-injurious behavior (SIB) refers to the intentional, direct injuring of one's own body without suicidal intentions. It is often repetitive and can take various forms such as cutting, burning, scratching, hitting, or bruising the skin. In some cases, individuals may also ingest harmful substances or objects.
SIB is not a mental disorder itself, but it is often associated with various psychiatric conditions, including borderline personality disorder, depression, anxiety disorders, post-traumatic stress disorder, and eating disorders. It is also common in individuals with developmental disabilities, such as autism spectrum disorder.
The function of SIB can vary widely among individuals, but it often serves as a coping mechanism to deal with emotional distress, negative feelings, or traumatic experiences. It's essential to approach individuals who engage in SIB with compassion and understanding, focusing on treating the underlying causes rather than solely addressing the behavior itself. Professional mental health treatment and therapy can help individuals develop healthier coping strategies and improve their quality of life.
Dimethoate
Pesticide toxicity to bees
Bactrocera tryoni
Maple
Chloroacetic acid
Olive fruit fly
Chorthippus brunneus
Alan Howard Ward
Creophilus maxillosus
Olive
Save the Hill Grove Cats
Aphis spiraecola
Dicofol
Sodium chloroacetate
Saluria inficita
Haplaxius crudus
Sawfly
Imidacloprid
Zoran Stanković
Estigmena chinensis
List of insecticides
List of MeSH codes (D02)
Fenthion
Acetylcholinesterase inhibitor
EPA list of extremely hazardous substances
Insecticide9
- Dimethoate is a widely used organophosphate insecticide and acaricide. (wikipedia.org)
- Dimethoate (DM), an organophosphate insecticide, has been used worldwide in agriculture and domestic for several years which has led to a variety of negative effects in non target species including humans. (scialert.net)
- Dimethoate is an organophosphate insecticide used to kill mites and insects systemically and on contact. (t3db.ca)
- Dimethoate is a systemic and contact organophosphorus insecticide registered for use in the U.S. in 1962 and used on several field grown agricultural crops (e.g., leaf greens, citrus, and melons), tree crops, and ornamentals. (tonyajoy.com)
- Technical Content of Rogor Insecticide : Dimethoate 30% EC. (tonyajoy.com)
- Is dimethoate a insecticide? (tonyajoy.com)
- dimethoate, any systemic insecticide that acts by inhibiting cholinesterases, enzymes involved in transmitting nerve impulses. (tonyajoy.com)
- Dimethoate-30% (Rogor) one amongst them is extensively used in horticulture as systemic insecticide. (tonyajoy.com)
- The insecticide dimethoate , an organophosphate , has been used on crops, soybeans , fruits , and vegetables since the 1960s and is considered one of the most widely used pesticides . (bvsalud.org)
OMETHOATE1
- Determination of enzymatic kinetics of metabolism of dimethoate and omethoate in rats and humans. (nih.gov)
Acephate2
- Dimethoate and methamidophos are not registered for use in the U.S. Acephate has been used to control insects on field and food crops, on ornamental plants, sods and turf, and in food handling establishments and around commercial and residential buildings. (cdc.gov)
- Control spider mites using acephate or dimethoate. (gardenguides.com)
PESTICIDES1
- Dimethoate (DM) [O,O-dimethyl-S(N-methylcarbomethyl) phosphorodithioate] which is one of the most important OP pesticides, is frequently used in agriculture against a wide range of insects and mites as both a systemic and a contact pesticide. (scialert.net)
Fenthion1
- In order to combat infestation, farmers treated crops with dimethoate and fenthion. (wikipedia.org)
Cholinesterase1
- Like other organophosphates, dimethoate is an acetylcholinesterase inhibitor which disables cholinesterase, an enzyme essential for central nervous system function. (wikipedia.org)
Malathion1
- Mealybugs are really hard to control and may require a Malathion based spray or one which contains dimethoate. (gardeningknowhow.com)
Crops2
- However, the understanding of the molecular mechanisms of dimethoate in crops, especially crop seedlings , is still limited. (bvsalud.org)
- Our study further enriches our understanding of the molecular mechanisms by which green vegetable soya beans are treated with dimethoate and provides a deeper understanding of the effects of dimethoate on crops. (bvsalud.org)
Toxic2
- Dimethoate is moderately toxic and severe poisoning affects the central nervous system. (t3db.ca)
- Integrated transcriptomic and metabolomic analyses reveal the toxic effects of dimethoate on green vegetable soya bean seedlings. (bvsalud.org)
Urine2
- A new, simple and rapid procedure for the determination of dimethoate in urine and blood samples was developed using direct immersion solid-phase microextraction and gas chromatography/mass spectrometry. (unboundmedicine.com)
- The mean absolute recoveries of dimethoate were 1.24 and 0.50% for urine and blood, respectively. (unboundmedicine.com)
Content1
- Grown in Poland and registered as Lithuanian, they contained a high content of cadmium, chlorpyrifos, and dimethoate - an absolute no-go. (thepoultrysite.com)
Pesticide1
- Dimethoate, one of a broad spectrum dithiophosphate pesticide, has also been studied as a target pollutant and its degradation behavior investigated using dielectric barrier discharge process. (tonyajoy.com)
Control2
- Dimethoate has been administered to livestock for control of botflies. (t3db.ca)
- An integrated analysis of the transcriptome and metabolome was performed to determine the responses of green vegetable soya bean seedlings to different concentrations (D1 for low dose , D2 for high dose and C for control) of dimethoate . (bvsalud.org)
Active2
- The reconsideration of the active constituent dimethoate, registration of products containing dimethoate and approvals of their associated labels. (apvma.gov.au)
- What is the active ingredient in dimethoate? (tonyajoy.com)
Effect1
- This study aimed to analyze the effect of dimethoate on the growth of green vegetable soya bean seedlings at the metabolic and transcriptional levels. (bvsalud.org)
Generation1
- We've numerous great employees customers excellent at promoting, QC, and working with kinds of troublesome difficulty inside the generation method for Dimethoate 4ec, Glyphosate 41 , 41 Glyphosate Weed Killer , Glyphosate 450 , Quizalofop-P-Ethyl Herbicide . (bigpesticides.com)
Model1
- Breakthrough curves were analysed using the two-site adsorption model and compared against dimethoate (DIM). (mdpi.com)
Insecticides4
- Sharkothoate EC (agricultural insecticide dimethoate 40%) is mixable with most fungicides and insecticides except alkaline and sulfur-based. (sharkvet.com)
- Employ insecticides that contain dimethoate. (gardenguides.com)
- The company diversified and commeced manufacture of insecticides like malathion dimethoate monocrotophos phosphamidon etc in 1981. (business-standard.com)
- Although olive fruit fly has been a pest in the Mediterranean and Middle East regions over the last century, management techniques used in those locations were unsuitable for California because these programs use restricted compounds such as dimethoate and fenthion (organophosphate insecticides) and also have the support of government-assisted, area-wide management programs for the pest. (ucr.edu)
Insecticide dimethoate1
- Sharkothoate EC (agricultural insecticide dimethoate 40%) is a cholinesterase inhibitor that affects the central nervous system and leads to respiratory arrest. (sharkvet.com)
Monocrotophos1
- endosulfan, monocrotophos, dimethoate, phosphamidon, carbaryl and cypermethrin using synergist TPP suppressible metabolic resistance even at 1:5 ratio in respect of monocrotophos and cypermethrin. (org.in)
Carcinogenicity1
- A bioassay of the carcinogenicity of technical-grade dimethoate was conducted using Osborne-Mendel rats and B6C3F1 mice. (nih.gov)
Toxicity5
- Omethoate appears to be responsible for dimethoate toxicity in insects and mammals (IPCS, 1989). (cdc.gov)
- Dimethoate has moderate acute toxicity in mammals (e.g., the LD50 in mice and rats is 150 and 400 mg/kg bodyweight, respectively) (IPCS, 1989). (cdc.gov)
- Genetic Toxicity Evaluation of Dimethoate in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
- Sasi S, ALghoul N, Awayn N, Elghoul A. Positive effect of green tea extract on reproductive toxicity induced by dimethoate in male mice. (openveterinaryjournal.com)
- Tremors and hyperexcitability, both indications of dimethoate toxicity, were observed in the treated animals. (nih.gov)
Organophosphorus1
- Dimethoate is a systemic and contact organophosphorus insecticide registered for use in the U.S. in 1962 and used on several field grown agricultural crops (e.g., leaf greens, citrus, and melons), tree crops, and ornamentals. (cdc.gov)
Cygon1
- June 2023 - CONFIRMED DIMETHOATE (LAGON® or Cygon®) resistant populations of two-spotted spider mite have been found in Ontario over the last two years from soybeans, dry beans, and other crops, including tomatoes, peppers, cucumbers, and strawberries. (ontariograinfarmer.ca)
Methamidophos1
- Dimethoate and methamidophos are not registered for use in the U.S. Acephate has been used to control insects on field and food crops, on ornamental plants, sods and turf, and in food handling establishments and around commercial and residential buildings. (cdc.gov)
Mice4
- Aim: This study was conducted to evaluate the positive effect of green tea extract on sperm quality and testicular cytoarchitecture in male mice treated with dimethoate and on its reproductive performance. (openveterinaryjournal.com)
- Methods: The mice were divided into three groups, each group contained nine mice, the first group (control) was given distilled water only, the second group received dimethoate at a dose (0.1 ml dimethoate /100 ml distilled water) while the third group was given dimethoate at a dose (0.1 ml dimethoate/ 100 ml distilled water) and the green tea extract at a dose (100 mg/kg). (openveterinaryjournal.com)
- 15. Genotoxicity evaluation of dimethoate to experimental mice by micronucleus, chromosome aberration tests, and comet assay. (nih.gov)
- Dimethoate was administered in feed to groups of 50 male and 50 female mice at two concentrations. (nih.gov)
Organophosphate insecticide1
- Dimethoate is a widely used organophosphate insecticide and acaricide. (wikipedia.org)
Tumors1
- Pathologic evaluation revealed no statistically significant increase in tumors associated with dimethoate treatment in either species of animal, and it is concluded that there was no carcinogenic effect under the conditions of the experiment. (nih.gov)
Farmers1
- Farmers have used dimethoate for decades. (abc.net.au)
Systemic insecticide1
- Dimethoate 2.67 is a systemic insecticide and miticide for broad spectrum control in a range. (drexchem.com)
Acetylcholinesterase1
- Dimethoate huwa insettiċida u akariċida organofosforu sistemiċi.Għandu qtil ta 'kuntatt qawwi u ċertu effett ta' avvelenament fl-istonku.Huwa inibitur ta 'acetylcholinesterase, li jimblokka l-konduzzjoni tan-nervituri u jikkawża mewt tal-insetti. (tangagri.com)
Broad-spectrum1
- Data are presented from a three-year study into the spatial dynamics of recovery of invertebrate populations following treatment with the broad-spectrum aphicide dimethoate. (soton.ac.uk)
Dose1
- In another case, an adult ingested food containing 17 ppm dimethoate (dose approximately 0/1 mg/kg) and provided serial urine specimens. (cdc.gov)
Phosphorodithioate1
- Dimethoate is the common name for the organophosphorous insecticide, o,o-dimethyl-S- (N-methylcarbamoyl- methyl)phosphorodithioate. (nih.gov)
Significantly1
- Results: The results showed that dimethoate significantly affected sperm quality a decrease in sperm motility and an increase in abnormal sperm morphology) and caused marked alterations in the microstructures of testicular tissues. (openveterinaryjournal.com)
Application1
- This paper describes an isotope dilution dimethoate assay based on the application of electrospray ionization tandem mass spectrometry (ESI-MS/MS) by means of a deuterium-labeled internal standard. (unical.it)
Study2
- The results from this study are discussed in terms of potential ecological and economic consequences of treatment with dimethoate. (soton.ac.uk)
- An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Dimethoate (60-51-5). (nih.gov)
Mobile1
- Dimethoate is nonvolatile, water soluble, and not mobile in soil, where it degrades with a half-life of approximately 2-4 days, based on soil conditions. (cdc.gov)
