Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.Dementia, Vascular: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Dementia, Multi-Infarct: Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgment, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY; HEMIPARESIS; reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)Lewy Body Disease: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Caregivers: Persons who provide care to those who need supervision or assistance in illness or disability. They may provide the care in the home, in a hospital, or in an institution. Although caregivers include trained medical, nursing, and other health personnel, the concept also refers to parents, spouses, or other family members, friends, members of the clergy, teachers, social workers, fellow patients.Mild Cognitive Impairment: A prodromal phase of cognitive decline that may precede the emergence of ALZHEIMER DISEASE and other dementias. It may include impairment of cognition, such as impairments in language, visuospatial awareness, ATTENTION and MEMORY.Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Nursing Homes: Facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization.Cognition: Intellectual or mental process whereby an organism obtains knowledge.Lewy Bodies: Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.tau Proteins: Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)Frontotemporal Lobar Degeneration: Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.Neurofibrillary Tangles: Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.Apolipoprotein E4: A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.Geriatric Assessment: Evaluation of the level of physical, physiological, or mental functioning in the older population group.Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.Pick Disease of the Brain: A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)Longitudinal Studies: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.Psychomotor Agitation: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Homes for the Aged: Geriatric long-term care facilities which provide supervision and assistance in activities of daily living with medical and nursing services when required.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Psychiatric Status Rating Scales: Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.Behavioral Symptoms: Observable manifestations of impaired psychological functioning.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Cholinesterase Inhibitors: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Wandering Behavior: Moving oneself through space while confused or otherwise cognitively impaired. Patterns include akathisia, exhibiting neuroleptic-induced pacing and restlessness; exit seekers who are often newly admitted institution residents who try to open locked exit doors; self-stimulators who perform other activities such as turning doorknobs, in addition to continuous pacing; and modelers who shadow other pacers.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Temporal Lobe: Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Institutionalization: The caring for individuals in institutions and their adaptation to routines characteristic of the institutional environment, and/or their loss of adaptation to life outside the institution.Activities of Daily Living: The performance of the basic activities of self care, such as dressing, ambulation, or eating.Amyloid beta-Peptides: Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.Plaque, Amyloid: Accumulations of extracellularly deposited AMYLOID FIBRILS within tissues.Autopsy: Postmortem examination of the body.Nootropic Agents: Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.Residential Facilities: Long-term care facilities which provide supervision and assistance in activities of daily living with medical and nursing services when required.Frontal Lobe: The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.Mental Competency: The ability to understand the nature and effect of the act in which the individual is engaged. (From Black's Law Dictionary, 6th ed).Aphasia, Primary Progressive: A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Geriatric Nursing: Nursing care of the aged patient given in the home, the hospital, or special institutions such as nursing homes, psychiatric institutions, etc.Supranuclear Palsy, Progressive: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Delirium: A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)Delirium, Dementia, Amnestic, Cognitive Disorders: Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, trauma, or other causes.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Brief Psychiatric Rating Scale: A scale comprising 18 symptom constructs chosen to represent relatively independent dimensions of manifest psychopathology. The initial intended use was to provide more efficient assessment of treatment response in clinical psychopharmacology research; however, the scale was readily adapted to other uses. (From Hersen, M. and Bellack, A.S., Dictionary of Behavioral Assessment Techniques, p. 87)Apathy: Lack of emotion or emotional expression; a disorder of motivation that persists over time.Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.Hallucinations: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.Assisted Living Facilities: A housing and health care alternative combining independence with personal care. It provides a combination of housing, personalized supportive services and health care designed to meet the needs, both scheduled and unscheduled, of those who need help with activities of daily living. ( Status: Educational attainment or level of education of individuals.Memantine: AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.Aphasia: A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.Behavior: The observable response of a man or animal to a situation.DNA Repeat Expansion: An increase number of repeats of a genomic, tandemly repeated DNA sequence from one generation to the next.Phenylcarbamates: Phenyl esters of carbamic acid or of N-substituted carbamic acids. Structures are similar to PHENYLUREA COMPOUNDS with a carbamate in place of the urea.

*  Diagnosis of Dementia and Use of Anti-dementia Medications - ppt video online download

AIDS and other dementias - Routine investigations in dementia 3. Determine which patients might benefit from anti-dementia ... Dementia with Lewy bodies - Subcortical dementias - Parkinson's disease dementia - Alcohol, traumatic brain injury, multiple ... Understand the clinical presentation and nature of common dementia syndromes Common dementia clinical syndromes - Alzheimer's ... Appreciate the safety concerns using anti-dementia and psychotropic drugs in older patients Cardiac effects - Sedation and ...

*  Hitchhiker's Guide to the Galaxy on Alcohol-related dementia

Alcohol-related dementia (ARD) is a form of dementia caused by long-term, excessive consumption of alcoholic beverages, ... "Alcoholic Dementia". Health. Retrieved 21 October 2015.. * ^ a b c d e "What's Alcohol-Related Dementia?". health- ... The onset of alcohol dementia can occur as early as age thirty,[7] although it is far more common that the dementia will reveal ... Probable Alcohol Related Dementia. A. The criteria for the clinical diagnosis of Probable Alcohol Related Dementia include the ...

*  Intervention Study to Improve Life and Care for People With Dementia and Their Caregivers in Primary Care - Full Text View -...

Other: Implementation of Dementia Care Manager Home-visits of trained 'Dementia Care Manager (DCM)' at least monthly for 6 ... This subsidiary support system is initiated by a Dementia Care Manager (DCM), a nurse with dementia-specific advanced training ... Experimental: Implementation of Dementia Care Manager Subjects in this arm will be provided with a specialised 'Dementia Care ... People assigned to the intervention group will receive an intervention provided by 'Dementia Care Manager'. The Dementia Care ...

*  Anxiety and fear - Changes in mood - Caring for someone with dementia - Living with dementia - Alzheimer Europe

Living with dementia *After diagnosis - What next? *Diagnosis of dementia *Disclosure of the diagnosis ... People with dementia sometimes feel afraid or are anxious. There are many possible reasons for this. Some people with dementia ... December 2015: 'Dementia, a priority of two EU Presidencies'. *June 2015: "The World Health Organisation and the World Dementia ... Caring for someone with dementia *The onset of the disease *Diagnosis: should the person with dementia be told? ...

*  The Impact of Autonomic Dysfunction on Survival in Patients with Dementia with Lewy Bodies and Parkinson's Disease with Dementia

Methods Thirty patients with dementia with Lewy bodies and Parkinson's disease with dementia were included in this prospective ... especially common in α-synucleinopathies like dementia with Lewy bodies and Parkinson's disease with dementia. The most common ... Introduction Autonomic dysfunction is a well-known feature in neurodegenerative dementias, ... Dementia with Lewy bodies Is the Subject Area "Dementia with Lewy bodies" applicable to this article? Yes. No. ...

*  Prevalence of cognitive impairment in Chinese: Epidemiology of Dementia in Singapore study | Journal of Neurology, Neurosurgery...

Cognitive impairment no dementia (CIND) and dementia were diagnosed according to internationally accepted criteria. The ... 80 CIND moderate and seven had dementia. The overall age adjusted prevalence of CIND mild was 7.2%; CIND moderate/dementia was ... Conclusions In present study, the overall prevalence of cognitive impairment and dementia in Chinese was 15.2%, which is in the ... Methods This study includes Chinese subjects from the Epidemiology of Dementia in Singapore (EDIS) study, aged ≥60 years, who ...

*  Dementia | BPS

Dementia: Promoting quality of life and an introduction to Positive Approaches to Care (PAC)™.. 09 May 2018 ... Psychological Dimensions of Dementia: Putting the Person at the Centre of Care. 12 November 2016 ... Society meets with parliamentarians for dementia discussion. A roundtable meeting is taking place today to bring together an ... New review says learning a second language won't protect you from dementia. 19 September 2017 ...

*  Dementia Challenge

Join Dementia Research. Join Dementia Research is a new service that helps people to take part in dementia research studies. It ... Dementia Friends. Dementia Friends is a programme to help people understand a bit more about dementia and the small things they ... Government policy on dementia. The Department of Health wants every person with dementia, and their carers and families, - from ... Beta version of new dementia site launched. This new Department of Health site on dementia has been launched as a 'beta', which ...

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Nine modifiable lifestyle factors that increase dementia risk have been identifies, including high blood pressure, obesity and ... Dementia is currently the leading cause of death in the England and Wales, while it is estimated that approximately 47 million ... 5 innovative apps that could help those with dementia A whole host of apps that can make life easier By Davina Ludlow ... "Although dementia is diagnosed in later life, the brain changes usually begin to develop years before. Acting now will vastly ...

*  Demonstrator sites | Dementia

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*  Alistair Burns | Dementia

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*  Raising Awareness | Dementia

Community support core principles Dementia Dementia Action Alliance Dementia Awareness day Dementia Awareness Week Dementia ... Prime Minister's challenge on dementia. The Prime Minister has launched a new challenge on dementia. This will be taking ... Published: January 28, 2013 , In Early diagnosis, Education and Training, Raising awareness , Tagged Dementia Awareness Week, ... Dementia campaign launches. The Department of Health has launched a campaign, supported by the Alzheimer's Society, to ...

*  Alzheimer's & Dementia Journal en App Store

Dementia Journal. Descarga Alzheimer's & Dementia Journal y disfrútalo en tu iPhone, iPad y iPod touch. ... About Alzheimer's & Dementia. The mission of Alzheimer's & Dementia: Journal of the Alzheimer's Association is to bridge the ... Alzheimer's & Dementia. The Journal of the Alzheimer's Association. It just got a whole lot easier to keep up with the latest ... The Alzheimer's & Dementia app brings you convenience of reading your favorite journal from anywhere in the world with just a ...

*  Detox, Diet and Dementia

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*  Alzheimer's Disease & Dementia | Alzheimer's Association

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*  Nutrition in Severe Dementia

M. Downs, N. Small, and K. Froggatt, "Person-centred care for people with severe dementia," in Severe Dementia, A. Burns and B ... J. Saxton and F. Boller, "Cognitive functions is severe dementia," in Severe Dementia, A. Burns and B. Winblad, Eds., pp. 43-49 ... 2. Definition of Severe Dementia. SD can be defined as the stage of the disease process of dementia in which cognitive deficits ... G. Gauthier, "Clinical features of severe dementia: function," in Severe Dementia, A. Burns and B. Winblad, Eds., pp. 117-121, ...

*  Dementia | Behavenet

Although classified as mental disorders because they involve deterioration in mental, behavioral, and emotional functioning, all these brain disorders are probably caused by physical disease, trauma or drug effect and are classified according to the underlying disease state.. ...

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*  Suspected early dementia | The BMJ

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*  Dementia Plan 2020 -

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*  Educated people cope better with dementia

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Familial British dementia: Familial British dementia is a form of dementia. It was first reported by Cecil Charles Worster-Drought in 1933 and is therefore also known as Worster-Drought syndrome.Alzheimer's Disease Neuroimaging Initiative: Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a worldwide project that provides reliable clinical data for the research of pathology principle, prevention and treatment of Alzheimer’s disease (AD). Multiple research groups contribute their findings of the biological markers to the understanding of the progression of Alzheimer’s disease in the human brain.Dennis Walsh: Dennis Walsh (12 June 1933 – 1 June 2005) was an English astronomer, born into a poor family in Manchester. He was best known for his discovery in 1979 of the first example of a gravitational lens which he made while studying quasars found in the Jodrell Bank 966MHz survey.Cognitive effects of HIVPostoperative cognitive dysfunction: Postoperative cognitive dysfunction (POCD) is a short-term decline in cognitive function (especially in memory and executive functions) that may last from a few days to a few weeks after surgery. In rare cases, this disorder may persist for several months after major surgery.Repeatable Battery for the Assessment of Neuropsychological Status: The Repeatable Battery for the Assessment of Neuropsychological Status is a neuropsychological assessment initially introduced in 1998. It consists of ten subtests which give five scores, one for each of the five domains tested (immediate memory, visuospatial/constructional, language, attention, delayed memory).Testicular atrophy: Testicular atrophy is a medical condition in which the male reproductive organs (the testes, which in humans are located in the scrotum) diminish in size and may be accompanied by loss of function. This does not refer to temporary changes, such as those brought on by cold.Home of the future: The home of the future, similar to the office of the future, is a concept that has been popular to explore since the early 20th century, or perhaps earlier. There have been many exhibits, such as at World's Fairs and theme parks, purporting to show how future homes will look and work, as well as standalone model "homes of the future" sponsored by builders, developers, or technology companies.Cognitive skill: Cognitive functioning is a term referring to a human’s ability to process to (thoughts) that should not deplete on a large scale in healthy individuals. Cognition mainly refers to things like memory, the ability to learn new information, speech, understanding of written material.LewyTau protein: Tau proteins (or τ proteins, after the Greek letter by that name) are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes.Causes of Parkinson's disease: Parkinson's disease (PD) is a degenerative disorder of the central nervous system. Most people with PD have idiopathic Parkinson's disease (having no specific known cause).Frontotemporal lobar degeneration: Frontotemporal lobar degeneration (FTLD) is a pathological process that occurs in frontotemporal dementia. It is characterized by atrophy in the frontal lobe and temporal lobe of the brain, with sparing of the parietal and occipital lobes.Neurofibrillary tangle: Neurofibrillary Tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary marker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies.Memory clinic: A memory clinic is a dedicated medical clinic specialising in the assessment and diagnosis of memory disorders. Memory clinics were first seen in the UK in the 1980s, mainly in academic research centres.Thomas Dao: Ling Yuan "Thomas" Dao (April 27, 1921 – July 16, 2009) was a Chinese American physician and specialist in breast cancer, its causes and treatment, who was one of the earliest proponents of minimalist alternatives to radical mastectomy as a treatment option for breast cancer, in addition to advocacy of breast self-examination and mammography as means to detect breast cancer as early as possible.Staff.Psychomotor agitationHyperintensityQRISK: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.Brodmann area 38: Brodmann area 38, also BA38 or temporopolar area 38 (H), is part of the temporal cortex in the human brain. BA 38 is at the anterior end of the temporal lobe, known as the temporal pole.Tumor progression: Tumor progression is the third and last phase in tumor development. This phase is characterised by increased growth speed and invasiveness of the tumor cells.Bristol Activities of Daily Living Scale: The Bristol Activities of Daily Living Scale (BADLS) is a 20-item questionnaire designed to measure the ability of someone with dementia to carry out daily activities such as dressing, preparing food and using transport.Senile plaquesDeath of Ludwig van Beethoven: The death of Ludwig van Beethoven on 26 March 1827 followed a prolonged illness. It was witnessed by his sister-in-law and by his close friend Anselm Hüttenbrenner, who provided a vivid description of the event.Coluracetam: Coluracetam (INN) (code name BCI-540; formerly MKC-231) is a nootropic agent of the racetam family. It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease.COPE FoundationMiddle frontal gyrus: The middle frontal gyrus makes up about one-third of the frontal lobe of the human brain. (A gyrus is one of the prominent "bumps" or "ridges" on the surface of the human brain.Primary progressive aphasia: Primary progressive aphasia (PPA) is a type of neurological syndrome in which language capabilities slowly and progressively become impaired while other mental functions remain intact. It was first described as a distinct syndrome by M.Centre for Research in Neurodegenerative DiseasesAge adjustment: In epidemiology and demography, age adjustment, also called age standardization, is a technique used to allow populations to be compared when the age profiles of the populations are quite different.Dudley MooreEmergence deliriumReduplicative paramnesia: Reduplicative paramnesia is the delusional belief that a place or location has been duplicated, existing in two or more places simultaneously, or that it has been 'relocated' to another site. It is one of the delusional misidentification syndromes and, although rare, is most commonly associated with acquired brain injury, particularly simultaneous damage to the right cerebral hemisphere and to both frontal lobes.Incidence (epidemiology): Incidence is a measure of the probability of occurrence of a given medical condition in a population within a specified period of time. Although sometimes loosely expressed simply as the number of new cases during some time period, it is better expressed as a proportion or a rate with a denominator.Silent strokeBrief Psychiatric Rating Scale: The Brief Psychiatric Rating Scale (BPRS) is rating scale which a clinician or researcher may use to measure psychiatric symptoms such as depression, anxiety, hallucinations and unusual behaviour.Overall JE, Gorham DR (1962).Voter apathy: In politics, voter apathy is perceived apathy (lack of caring) among voters in an election. Voter apathy or lack of interest is often cited as a cause of low turnout among eligible voters in jurisdictions where voting is optional and the donkey vote where voting is compulsory.Explicit memory: Explicit memory is the conscious, intentional recollection of previous experiences and information. People use explicit memory throughout the day, such as remembering the time of an appointment or recollecting an event from years ago.TBR1: T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene.Peduncular hallucinosis: Peduncular hallucinosis (PH), or Lhermitte's peduncular hallucinosis, is a rare neurological disorder that causes vivid visual hallucinations that typically occur in dark environments, and last for several minutes. Unlike some other kinds of hallucinations, the hallucinations that patients with PH experience are very realistic, and often involve people and environments that are familiar to the affected individuals.Curotek: Curotek is an American company based in Portland, Oregon that provides technology for community-based care settings such as assisted living communities and group home settings serving those with Dementia, Alzheimer's, Mental Retardation and Developmental Disabilities and other disabilities that cause safety risks associated with freedom of movement and personal autonomy. Curotek provides various hardware devices providing real-time tracking of residents and care staff, an alert system tied to various sensor devices such as bed pads and thresholds and an electronic door control system that locks and unlocks doors based on the proximity of tracking badges.MemantineBoston Diagnostic Aphasia Examination: The Boston Diagnostic Aphasia Examination or BDAE is a neuropsychological battery used to evaluate adults suspected of having aphasia, and is currently in its third edition. It was created by Harold Goodglass and Edith Kaplan.

(1/3586) Assessment of competence to complete advance directives: validation of a patient centred approach.

OBJECTIVE: To develop a patient centred approach for the assessment of competence to complete advance directives ("living wills") of elderly people with cognitive impairment. DESIGN: Semistructured interviews. SETTING: Oxfordshire. SUBJECTS: 50 elderly volunteers living in the community, and 50 patients with dementia on first referral from primary care. MAIN OUTCOME MEASURES: Psychometric properties of competence assessment. RESULTS: This patient centred approach for assessing competence to complete advance directives can discriminate between elderly persons living in the community and elderly patients with dementia. The procedure has good interrater (r=0.95) and test-retest (r=0.97) reliability. Validity was examined by relating this approach with a global assessment of competence to complete an advance directive made by two of us (both specialising in old age psychiatry). The data were also used to determine the best threshold score for discriminating between those competent and those incompetent to complete an advance directive. CONCLUSION: A patient centred approach to assess competence to complete advance directives can be reliably and validly used in routine clinical practice.  (+info)

(2/3586) Disrupted temporal lobe connections in semantic dementia.

Semantic dementia refers to the variant of frontotemporal dementia in which there is progressive semantic deterioration and anomia in the face of relative preservation of other language and cognitive functions. Structural imaging and SPECT studies of such patients have suggested that the site of damage, and by inference the region critical to semantic processing, is the anterolateral temporal lobe, especially on the left. Recent functional imaging studies of normal participants have revealed a network of areas involved in semantic tasks. The present study used PET to examine the consequences of focal damage to the anterolateral temporal cortex for the operation of this semantic network. We measured PET activation associated with a semantic decision task relative to a visual decision task in four patients with semantic dementia compared with six age-matched normal controls. Normals activated a network of regions consistent with previous studies. The patients activated some areas consistently with the normals, including some regions of significant atrophy, but showed substantially reduced activity particularly in the left posterior inferior temporal gyrus (iTG) (Brodmann area 37/19). Voxel-based morphometry, used to identify the regions of structural deficit, revealed significant anterolateral temporal atrophy (especially on the left), but no significant structural damage to the posterior inferior temporal lobe. Other evidence suggests that the left posterior iTG is critically involved in lexical-phonological retrieval: the lack of activation here is consistent with the observation that these patients are all anomic. We conclude that changes in activity in regions distant from the patients' structural damage support the argument that their prominent anomia is due to disrupted temporal lobe connections.  (+info)

(3/3586) Subcortical arteriosclerotic encephalopathy (Binswanger's disease). A vascular etiology of dementia.

A 51-yearold man with moderate intermittent hypertension had a rapidly progressive, profound dementia in the absence of significant localizing neurological signs. Postmortem examination disclosed the vascular alterations and diffuse white matter degeneration which characterize subcortical arteriosclerotic encephalopathy (SAE) or Binswanger's disease. The case underscores the need to consider vascular disease as an etiology of dementia -- even in the absence of focal neurological deficit.  (+info)

(4/3586) Are sex and educational level independent predictors of dementia and Alzheimer's disease? Incidence data from the PAQUID project.

OBJECTIVES: To examine the age specific risk of Alzheimer's disease according to sex, and to explore the role of education in a cohort of elderly community residents aged 65 years and older. METHODS: A community based cohort of elderly people was studied longitudinally for 5 years for the development of dementia. Dementia diagnoses were made according to the DSM III R criteria and Alzheimer's disease was assessed using the NINCDS-ADRDA criteria. Among the 3675 non-demented subjects initially included in the cohort, 2881 participated in the follow up. Hazard ratios of dementia were estimated using a Cox model with delayed entry in which the time scale is the age of the subjects. RESULTS: During the 5 year follow up, 190 incident cases of dementia, including 140 cases of Alzheimer's disease were identified. The incidence rates of Alzheimer's disease were 0.8/100 person-years in men and 1.4/100 person-years in women. However, the incidence was higher in men than in women before the age of 80 and higher in women than in men after this age. A significant interaction between sex and age was found. The hazard ratio of Alzheimer's disease in women compared with men was estimated to be 0.8 at 75 years and 1.7 at 85 years. The risks of dementia and Alzheimer's disease were associated with a lower educational attainment (hazard ratio=1.8, p<0.001). The increased risk of Alzheimer's disease in women was not changed after adjustment for education. CONCLUSION: Women have a higher risk of developing dementia after the age of 80 than men. Low educational attainment is associated with a higher risk of Alzheimer's disease. However, the increased risk in women is not explained by a lower educational level.  (+info)

(5/3586) Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer's disease and frontotemporal dementia.

OBJECTIVES: The diagnosis of Alzheimer's disease (AD) is now reliant on the use of NINCDS-ADRDA criteria. Other diseases causing dementia are being increasingly recognised--for example, frontotemporal dementia (FTD). Historically, these disorders have not been clearly demarcated from AD. This study assesses the capability of the NINCDS-ADRDA criteria to accurately distinguish AD from FTD in a series of pathologically proved cases. METHODS: The case records of 56 patients (30 with AD, 26 with FTD) who had undergone neuropsychological evaluation, brain imaging, and ultimately postmortem, were assessed in terms of whether at initial diagnosis the NINCDS-ADRDA criteria were successful in diagnosing those patients who had AD and excluding those who did not. RESULTS: (1) The overall sensitivity of the NINCDS-ADRDA criteria in diagnosing "probable" AD from 56 patients with cortical dementia (AD and FTD) was 0.93. However, the specificity was only 0.23; most patients with FTD also fulfilled NINCDS-ADRDA criteria for AD. (2) Cognitive deficits in the realms of orientation and praxis significantly increased the odds of a patient having AD compared with FTD, whereas deficits in problem solving significantly decreased the odds. Neuropsychological impairments in the domains of attention, language, perception, and memory as defined in the NINCDS-ADRDA statement did not contribute to the clinical differentiation of AD and FTD. CONCLUSION: NINCDS-ADRDA criteria fail accurately to differentiate AD from FTD. Suggestions to improve the diagnostic specificity of the current criteria are made.  (+info)

(6/3586) Relationship between brain atrophy estimated by a longitudinal computed tomography study and blood pressure control in patients with essential hypertension.

To evaluate the relationship between blood pressure control and the progression of brain atrophy in the elderly, patients with essential hypertension and brain atrophy were longitudinally evaluated using computerized tomography (CT). The study evaluated 48 patients with essential hypertension aged 46-78 years, and 30 sex- and age-matched normotensive control subjects. The extent of brain atrophy as determined by caudate head index (CHI), the inverse cella media index (iCMI), and Evans' ratio (ER) was estimated twice at an interval of 5-9 years (mean, 6.9 years). The mean annual increases in CHI (deltaCHI), iCMI (delta iCMI), and ER (deltaER) were evaluated. Mean blood volume in the common carotid artery (BF) and the decrease in BF per year (deltaBF) were also determined. The deltaCHI, delta iCMI, and deltaER increased with age in the hypertensive subjects as well as the control group across all age groups evaluated. The deltaCHI, delta iCMI, and deltaER were significantly greater in the patients with essential hypertension in their 50 s as compared with the controls. In patients with essential hypertension aged 65 years or older, the deltaCHI, delta iCMI, and deltaER were significantly lower in the group in whom the blood pressure was controlled within the range of borderline hypertension than the groups in which it was controlled in the range of normal or mild hypertension. In the younger patients under the age of 65 with essential hypertension, blood pressure control did not affect the deltaCHI, delta iCMI, and deltaER. The deltaCHI, delta iCMI, and deltaER were significantly correlated with deltaBF in both groups. These findings indicate that control of systolic blood pressure within the range of borderline hypertension may delay the progression of brain atrophy in elderly patients with essential hypertension.  (+info)

(7/3586) EEG findings in dementia with Lewy bodies and Alzheimer's disease.

OBJECTIVES: To evaluate the role of the EEG in the diagnosis of dementia with Lewy bodies (DLB). METHODS: Standard EEG recordings from 14 patients with DLB confirmed at postmortem were examined and were compared with the records from 11 patients with Alzheimer's disease confirmed at postmortem RESULTS: Seventeen of the total of 19 records from the patients with DLB were abnormal. Thirteen showed loss of alpha activity as the dominant rhythm and half had slow wave transient activity in the temporal lobe areas. This slow wave transient activity correlated with a clinical history of loss of consciousness. The patients with Alzheimer's disease were less likely to show transient slow waves and tended to have less marked slowing of dominant rhythm. CONCLUSIONS: The greater slowing of the EEG in DLB than in Alzheimer's disease may be related to a greater loss of choline acetyltransferase found in DLB. Temporal slow wave transients may be a useful diagnostic feature in DLB and may help to explain the transient disturbance of consciousness which is characteristic of the disorder.  (+info)

(8/3586) Outcome measures for routine use in dementia services: some practical considerations.

OBJECTIVES: To work with specialist community teams to assess the practicality and acceptability of identified outcome measures for routine use in dementia services. SETTING: Seven specialist dementia services: four multidisciplinary teams, a specialist service for carers, a community psychiatric nurse team, and a day hospital. SUBJECTS: 20 members of staff from the specialist dementia services including psychiatry, community psychiatric nursing, social work, occupational therapy, Admiral nursing, ward management, geriatric nursing. MAIN MEASURE: A questionnaire designed to assess staff views on the use of six outcome measures in routine practice in terms of practicality, relevance, acceptability, and use in improving care. RESULTS: Each of the outcome measures took 15 to 30 minutes to administer. All were rated as easy to use and as relevant to dementia services and to carers. Staff commented that the measures could be useful in routine practice for structured assessment and service evaluation, but highlighted the need for sensitive use of measures with carers. CONCLUSIONS: These measures consider the main domains of functioning for people with dementia and their carers. The measures are suitable for use in routine practice in dementia services and are acceptable to staff and carers. The project underlined the need for management support, staff ownership of measures, and training in using outcome measures. Staff concerns about service evaluation need to be acknowledged.  (+info)


  • The Department of Health wants every person with dementia, and their carers and families, to receive high quality, compassionate care from diagnosis through to end of life care. (
  • In this short audio clip, Martin Freeman, regional lead on dementia in the South West of England, talks to National Clinical Director for Dementia Alistair Burns about the importance of early diagnosis. (
  • Much clinical attention and research effort has been directed towards early diagnosis and mild stages of dementia, and prodromal stages, formerly classified as mild cognitive impairment (MCI). (
  • A dementia diagnosis requires a change from a person's usual mental functioning and a greater decline than one would expect due to aging. (
  • The symptoms of dementia vary across types and stages of the diagnosis. (
  • Agitation often accompanies dementia and often precedes the diagnosis of common age-related disorders of cognition such as Alzheimer's disease (AD). (
  • Dementia praecox (a "premature dementia" or "precocious madness") is a disused psychiatric diagnosis that originally designated a chronic, deteriorating psychotic disorder characterized by rapid cognitive disintegration, usually beginning in the late teens or early adulthood. (

less likely to develop dementia

  • It's now a common idea that education strengthens the brain, meaning you're less likely to develop dementia. (
  • Married people tend to have healthier lifestyles and are more socially engaged, which may explain why they're less likely to develop dementia," said the study's lead author, Dr Andrew Sommerlad (UCL Psychiatry). (


  • Alzheimer's is a progressive disease, where dementia symptoms gradually worsen over a number of years. (
  • Although current Alzheimer's treatments cannot stop Alzheimer's from progressing, they can temporarily slow the worsening of dementia symptoms and improve quality of life for those with Alzheimer's and their caregivers. (
  • Anyone experiencing dementia-like symptoms should see a doctor as soon as possible. (
  • Dementia is also terrifying to us because of its disturbing symptoms and limited treatment options. (
  • Anxiety and depression are associated with cognitive symptoms and they also complicate established dementia. (
  • Our study shows education in early life appears to enable some people to cope with a lot of changes in their brain before showing dementia symptoms, Keage said. (
  • In the first stages of dementia, the signs and symptoms of the disorder may be subtle. (
  • Signs and symptoms are classified into three groups based on the functions of the frontal and temporal lobes: Behavioural variant frontotemporal dementia (BvFTD) is characterized by changes in social behavior and conduct, with loss of social awareness and poor impulse control. (
  • Steroid dementia syndrome describes the signs and symptoms of hippocampal and prefrontal cortical dysfunction, such as deficits in memory, attention, and executive function, induced by glucocorticoids. (
  • Dementia-like symptoms have been found in some individuals who have been exposed to glucocorticoid medication, often dispensed in the form of asthma, arthritis, and anti-inflammatory steroid medications. (


  • Naming and behavioural problems are commonly seen within the frontotemporal lobar degeneration spectrum, which includes behavioural variant frontotemporal dementia (previously Pick's disease), progressive non-fluent aphasia, and semantic dementia (fluent speech with loss of word meaning). (
  • Until the seventeenth century dementia referred to states of cognitive and behavioural deterioration leading to psychosocial incompetence. (

frontotemporal lobar degene

  • SD is one of the three canonical clinical syndromes associated with frontotemporal lobar degeneration (FTLD), with the other two being frontotemporal dementia and progressive nonfluent aphasia. (
  • Based on these imaging methods, semantic dementia can be regionally dissociated from the other subtypes of frontotemporal lobar degeneration, frontotemporal dementia, and progressive nonfluent aphasia. (
  • Frontotemporal dementia (FTD) is the clinical presentation of frontotemporal lobar degeneration, which is characterized by progressive neuronal loss predominantly involving the frontal or temporal lobes, and typical loss of over 70% of spindle neurons, while other neuron types remain intact. (

lower dementia risk

  • Some studies have suggested that people who eat more oily fish are at a lower dementia risk - but research in this area is still ongoing . (
  • Couples may also have more opportunities for social engagement than single people--a factor that has been linked to better health and lower dementia risk, they suggest. (


  • The history of memory and executive decline in the context of fluctuations makes dementia with Lewy bodies possible, even without parkinsonism or visual hallucinations. (
  • Even in the absence of disease modifying therapies, other dementia disorders still require specific treatment strategies, such as modification of vascular risk factors in vascular cognitive impairment, and acetylcholinesterase inhibition for Alzheimer's disease and dementia with Lewy bodies, for example. (
  • Other common types include vascular dementia (25%), Lewy body dementia (15%), and frontotemporal dementia. (


  • Semantic dementia (SD), also known as semantic variant primary progressive aphasia (svPPA), is a progressive neurodegenerative disorder characterized by loss of semantic memory in both the verbal and non-verbal domains. (
  • It is important to note the distinctions between Alzheimer's Disease and Semantic dementia with regard to types of memory affected. (
  • Semantic dementia generally affects semantic memory, which refers to long-term memory that deals with common knowledge and facts.3 It was first described by Arnold Pick in 1904 and in modern times was characterized by Professor Elizabeth Warrington in 1975, but it was not given the name semantic dementia until 1989. (
  • Semantic dementia (SD) is characterized by the loss of semantic understanding, resulting in impaired word comprehension, although speech remains fluent and grammatically faultless. (


  • Vascular dementia, also known as multi-infarct dementia (MID) and vascular cognitive impairment (VCI), is dementia caused by problems in the supply of blood to the brain, typically a series of minor strokes, leading to worsening cognitive decline that occurs step by step. (

mild cognitive

  • People with vascular dementia present with progressive cognitive impairment, acutely or subacutely as in mild cognitive impairment, frequently step-wise, after multiple cerebrovascular events (strokes). (

form of dementia

  • Alzheimer's is the most common form of dementia, a general term for memory loss and other cognitive abilities serious enough to interfere with daily life. (
  • Familial British dementia is a form of dementia. (

cause of dementia

  • Alzheimer's disease is the most common neurodegenerative cause of dementia. (
  • On rare occasion, infarcts in the hippocampus or thalamus are the cause of dementia. (

types of dementia

  • Most types of dementia are slow and progressive. (
  • It is possible for a patient to have two types of dementia at the same time. (
  • Although it occurs in several types of dementia, wandering is especially common in people with Alzheimer's disease (AD). (

Alistair Burns

  • Paul Mancey, chief executive of Orchard Care Homes, talks to Alistair Burns about work to improve the quality of life of residents with dementia, including an Alzheimer's Society training programme for staff. (
  • Alistair Burns caught up with Dr Nigel Watson, a GP, at the NHS South of England Dementia Challenge Conference on 29 May. (

severe dementia

  • The objective of this paper is to present methods for evaluating the nutritional status of patients with severe dementia as well as measures for the treatment of nutritional disorders, the use of vitamin and mineral supplementation, and indications for ANH and pharmacological therapy. (
  • Severe dementia (SD) is still relatively neglected and its prevalence is unclear, but it is estimated that one-third of dementia patients are in the severe stages [ 4 - 6 ]. (
  • Severe Dementia is a death metal band from Dhaka, Bangladesh. (
  • Severe Dementia draws it's lyrical themes from ancient and historical events which created a major impact on certain nations and the human race. (
  • In February 2007, Severe Dementia signed a deal with Demonstealer Records (India) to release an EP in a split album "Rise of the Eastern Blood" with Demonic Resurrection (India), Dusk (Pakistan) and Helmksey (Singapore). (
  • It contains five tracks- Their other tracks are- Defloracioun of Tiamat (Demo) Emissaries Of Kingu (Demo) Shudder Thee Incensed Goddess (Demo) Slayer Of The Snarling Tormentor (Demo) The Tormentor Demented Mentation Severe Dementia undertook a tour in India in April 2007 as being the first ever underground band from Bangladesh to play overseas. (

national dementia

  • This will be taking forward the aims of the National Dementia Strategy, but at a faster pace and including a range of new initiatives and commitments. (
  • Critically, distinguishing these causes from one another has implications for management, as acknowledged in UK national dementia guidelines. (
  • Several countries are now making national dementia plans. (


  • Psychosis (often delusions of persecution) and agitation/aggression also often accompany dementia. (
  • There is no FDA-approved treatment for agitation in dementia. (


  • Differentiating the different dementia syndromes can be challenging, due to the frequently overlapping clinical features and related underlying pathology. (

cognitive decline

  • Stroke patients who take two common blood pressure medications are less likely to suffer dementia or cognitive decline if they have another stroke, finds a new study in this month's Archives of Internal Medicine. (
  • Three large studies offered conflicting results: One suggested blood pressure treatment could reduce the risk for dementia but not cognitive decline, a second came out with the opposite finding, and a third showed a beneficial effect but included only a small number of dementia cases. (
  • Signs are typically the same as in other dementias, but mainly include cognitive decline and memory impairment of sufficient severity as to interfere with activities of daily living, sometimes with presence of focal neurologic signs, and evidence of features consistent with cerebrovascular disease on brain imaging (CT or MRI). (

Alzheimer's Association

  • This latest study, which is being presented at the Alzheimer's Association International Conference in London, combined the work of 29 globally renowned experts to identify the nine modifiable lifestyle factors that contribute to increased dementia risk - all of which add up to 35% of overall impact. (
  • The mission of Alzheimer's & Dementia: Journal of the Alzheimer's Association is to bridge the knowledge gaps across a wide range of bench-to-bedside investigation. (


  • While the condition generally falls under the classification of Cushing's syndrome, the term "steroid dementia syndrome" is particularly useful because it recognizes both the cause of the syndrome and the specific effects of glucocorticoids on cognitive function. (
  • a different mutation of the same gene causes the similar syndrome of familial Danish dementia. (


  • Dementia is one of the greatest social challenges facing the international community, and must be meet of both globally, nationally and locally. (
  • Developing ways of preventing dementia is becoming more and more important for governments worldwide as the number of dementia cases globally is expected to almost double every 20 years to 66 million in 2030 and over 115 million in 2050, and the cost of coping with the disease in aging populations is forecast to rise dramatically in the coming decades. (
  • Globally, dementia affected about 46 million people in 2015. (


  • Five new videos from the Department of Health highlight a range of initiatives to support people with dementia in different areas of England. (
  • Join Dementia Research is a new service that helps people to take part in dementia research studies. (
  • Ahead of Dementia Awareness Week, starting on 20 May, I speak with Dot Gibson, National Prescribing Centre (NPC) general secretary and start by asking about her headline-making objection to police using GPS devices to track people with dementia. (
  • A: Fitting a GPS device to people with dementia is like using sticking plaster to hide the crisis in health and social care. (
  • This is what I said in media interviews following the news that more than 100 local authorities are using GPS devices to track people with dementia and now Sussex police have adopted the scheme to save money when they are called out to find a missing dementia sufferer. (
  • This means that unless they are rich enough to buy personal, professional 24-hour care, people with dementia are often limited to one or two visits a day to help them bathe, eat and go to bed. (
  • Dementia is currently the leading cause of death in the England and Wales, while it is estimated that approximately 47 million people worldwide are currently living with the condition. (
  • Acting now will vastly improve life for people with dementia and their families and, in doing so, will transform the future of society. (
  • The Department of Health has launched a campaign, supported by the Alzheimer's Society, to encourage people to talk to loved ones showing signs of dementia. (
  • A recent review by the Cochrane Collaboration (internationally recognised as the highest standard in evidence-based healthcare) reported that exercise can also improve cognition in people with dementia. (
  • Dementia-acquired, progressive cognitive impairment sufficient to impair activities of daily living-is more typically encountered in older people, but is not uncommon at younger ages. (
  • The goal of the Dementia Plan 2020 is to build a more dementia-friendly society, where people with dementia are cared for and integrated in the community. (
  • The plan has been developed in close cooperation with people who themselves have dementia, together with their families. (
  • The aim is to ensure long-term, integrated planning for the local community and the physical environment, and high-quality services designed to meet the needs of the growing number of people with dementia and their families. (
  • The plan is available in both a full-length version and a short easy access version for people with dementia and cognitive impairments. (
  • The researchers found that people who go on to university or college after leaving school appear to be less affected by the brain changes, or pathology, associated with dementia than those who stop education earlier. (
  • Over the past decade, studies on dementia have shown that the more time you spend in education, the lower your risk of dementia -- but until now scientists had not known whether this was because education somehow protected the brain against damage, or because it made people better able to cope. (
  • Around 35 million people around the world have dementia. (
  • The widowed were 20 per cent more likely to develop dementia than married people, although the strength of this association was somewhat weakened when educational attainment was factored in. (
  • We hope that our findings could be applied to support dementia prevention among unmarried people, as maintaining physical health and ensuring mental stimulation through social engagement among unmarried older people may be beneficial," said Dr Sommerlad. (
  • There are many measures that can improve the quality of life of people with dementia and their caregivers. (
  • About 3% of people between the ages of 65-74 have dementia, 19% between 75 and 84 and nearly half of those over 85 years of age. (
  • As more people are living longer, dementia is becoming more common in the population as a whole. (
  • People with dementia are often physically or chemically restrained to a greater degree than necessary, raising issues of human rights. (
  • About 10% of people with dementia have what is known as mixed dementia, which is usually a combination of Alzheimer's disease and another type of dementia such as frontotemporal dementia or vascular dementia. (
  • Wandering, in people with dementia, is a common behavior that can cause great risk for the person, and is often the major priority (and concern) for caregivers. (
  • It is estimated to be the most common form of disruption from people with dementia within institutions. (
  • A review of medical records of 83 people with dementia living in Los Angeles, found that only 8% of the records included a wandering risk assessment. (
  • Cerebral amyloid angiopathy can, however, appear in people with no prior dementia condition. (


  • In the DSM-5, dementia was reclassified as a neurocognitive disorder, with various degrees of severity. (
  • Dementia is a cognitive disorder. (


  • Dementia: The International Journal of Social Research and Practice is a bimonthly peer-reviewed academic journal that covers research in the field of geriatrics. (


  • In particular, Alzheimer's dementia often co-occurs with vascular dementia. (
  • Consequently, patients with vascular dementia tend to perform worse than their Alzheimer's disease counterparts in frontal lobe tasks, such as verbal fluency, and may present with frontal lobe problems: apathy, abulia, problems with attention, orientation, and urinary incontinence. (
  • Apathy early in the disease is more suggestive of vascular dementia. (
  • Vascular dementia can be caused by ischemic or hemorrhagic infarcts affecting multiple brain areas, including the anterior cerebral artery territory, the parietal lobes, or the cingulate gyrus. (
  • Vascular dementia can sometimes be triggered by cerebral amyloid angiopathy, which involves accumulation of beta amyloid plaques in the walls of the cerebral arteries, leading to breakdown and rupture of the vessels. (
  • Since amyloid plaques are a characteristic feature of Alzheimer's Disease, vascular dementia may occur as a consequence. (


  • Tau-positive frontotemporal dementia with parkinsonism (FTDP-17) is caused by mutations in the MAPT gene on chromosome 17 that encodes the Tau protein It has been determined that there is a direct relationship between the type of tau mutation and the neuropathology of gene mutations. (


  • By the eighteenth century, at the period when the term entered into European medical discourse, clinical concepts were added to the vernacular understanding such that dementia was now associated with intellectual deficits arising from any cause and at any age. (


  • As the disease progresses, behavioral and personality changes are often seen similar to those seen in frontotemporal dementia. (


  • Although dementia is diagnosed in later life, the brain changes usually begin to develop years before. (
  • Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning. (


  • A search and rescue mission lasting more than a few hours is likely to expend many hundreds to thousands to tens of thousands of skilled worker hours and, per mission, those involving subjects with dementia typically expend significantly more resources than others. (


  • Dementia is a 2014 Filipino horror film directed by Perci Intalan, in his directorial debut. (


  • The remaining 65% of dementia risk is thought to be beyond the individual's control. (
  • Content emphasizes interdisciplinary investigations, integrative/translational articles, related to: etiology, risk factors, early detection, disease modifying interventions, prevention of dementia and applications of new technologies in health services. (
  • Together with exercise, keeping healthy has so far been shown to be the best way to lower your risk of dementia. (
  • It can help us keep a healthy weight, which lowers our risk of high blood pressure, diabetes and heart disease, and in turn, dementia. (
  • More specifically, a Mediterranean diet often hits the headlines, as there has been some research suggesting following this diet may lower our risk of dementia . (
  • There have been reports that curry, 'super foods' like berries or broccoli and particular drinks like apple juice or red wine can lower the risk of developing Alzheimer's or dementia. (
  • Of all the things that may lower your dementia risk - this is the one with the most evidence behind it. (
  • The biggest risk factor for dementia is age. (
  • By leading a healthy lifestyle and taking regular exercise you will be lowering your risk of these diseases, and it's likely you will lower your risk of dementia too. (
  • Studies suggest it's particularly important to keep healthy in mid-life to help lower your risk of dementia. (
  • Results showed no clear-cut effect of the active treatment on the overall risk of dementia, but the risk of developing dementia with recurrent stroke was lowered by about a third in those who took the blood pressure medications. (
  • It also found that for every extra year of education there was an 11 percent decrease in the risk of developing dementia. (
  • Marriage may lower the risk of developing dementia, concludes a UCL-led synthesis of the available evidence published online in the Journal of Neurology Neurosurgery & Psychiatry . (
  • These looked at the potential role of marital status on dementia risk, and involved more than 800,000 participants from Europe, North and South America, and Asia. (
  • Marriage may help both partners to have healthier lifestyles, including exercising more, eating a healthy diet, and smoking and drinking less, all of which have been associated with lower risk of dementia. (
  • Efforts to prevent dementia include trying to decrease risk factors such as high blood pressure, smoking, diabetes, and obesity. (


  • Alzheimer's disease accounts for 60 to 80 percent of dementia cases. (
  • An increasing proportion of older adults with Alzheimer's disease or other dementias are now surviving to more advanced stages of the illness. (
  • Dementia is one of the most common and most significant health problems in the elderly and is one of the main causes of disability in older age [ 1 ] A growing proportion of older adults with Alzheimer disease (AD) or other dementias are now surviving to more advanced stages of the illness [ 2 , 3 ]. (
  • There was a family history of cardiovascular disease but not of dementia. (
  • Keage's team said that in the United States for example, if the onset of dementia could be delayed by two years in those aged over 50, there would be nearly two million fewer cases of dementia over the next 40 years -- a reduction that would also dramatically cut the projected economic costs of the disease. (
  • The most common type of dementia is Alzheimer's disease, which makes up 50% to 70% of cases. (
  • Kraepelin viewed dementia praecox as a progressively deteriorating disease from which no one recovered. (
  • While some have sought to interpret, if in a qualified fashion, the use by Morel of the term démence précoce as amounting to the "discovery" of schizophrenia, others have argued convincingly that Morel's descriptive use of the term should not be considered in any sense as a precursor to Kraepelin's dementia praecox disease concept. (
  • It was first described by Arnold Pick in 1892 and was originally called "Pick's disease", a term now reserved for Pick disease, one specific type of frontotemporal dementia. (
  • Second only to Alzheimer's disease (AD) in prevalence, FTD accounts for 20% of young-onset dementia cases. (
  • Theroux also meets individuals in the Phoenix area who are trying to keep relationships alive with loved ones with dementia as their disease progresses. (


  • We welcome the broader, societal approach outlined in this research, and certainly the idea that we all need to take individual responsibility, usually by making relatively small lifestyle changes - at all stages of life - to 'dementia-proof' our own health, and that of our families. (


  • Over the years, the term "dementia praecox" was gradually replaced by "schizophrenia", which remains in current diagnostic use. (
  • This is due to the fact that their concepts of dementia differed significantly from each other, with Kraepelin employing the more modern sense of the word and that Morel was not describing a diagnostic category. (


  • The primary disturbance in dementia praecox was seen to be a disruption in cognitive or mental functioning in attention, memory, and goal-directed behaviour. (


  • The term "dementia praecox" was first used in 1891 by Arnold Pick (1851-1924), a professor of psychiatry at Charles University in Prague. (


  • With progressive dementia, patients become incompetent to make decisions. (


  • It just got a whole lot easier to keep up with the latest research articles and reviews in the area of Alzheimer's and dementia. (
  • Alzheimer's Research UK is funding research into all of these factors to try and understand more about dementia. (


  • A Ten Step Toolkit for Clinicians Involved in End of Life Discussions' has been launched specifically for those dealing with dementia patients and their families. (
  • Because patients with dementia have limited language and communication abilities, it is difficult to identify the source of aversive behavior [ 9 , 10 ]. (


  • A: Successive governments designate the needs of dementia sufferers as personal and not medical and so only entitled to means-tested social care, meaning that many end up selling their homes to pay for this or are forced to use up all their savings. (
  • Listen to the audio clip where they talk about the key elements of good dementia care. (
  • This will require greater openness and knowledge about dementia in society in general and in the health and care services in particular. (
  • Theroux travels to the city of Phoenix, Arizona, considered the capital of dementia care, spending time at Beatitudes, a residential institution for those with dementia. (


  • The strategies and measures in the Dementia Plan 2020 are intended to help put dementia and its challenges on the agenda of ordinary municipal planning. (


  • Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior. (
  • More than one type of dementia may exist in the same person. (


  • Dementia is a major health concern in developed nations, ranking as the eighth leading cause of death and disability. (
  • The findings by scientists from Britain and Finland could have important implications for public health at a time when populations in many countries are rapidly aging and dementia numbers are expected to rise sharply. (


  • Unfortunately not, as dementia is caused by a range of diseases, with complex causes. (