Collagen Type XI
Collagen
Contacts with fibrils containing collagen I, but not collagens II, IX, and XI, can destabilize the cartilage phenotype of chondrocytes. (1/125)
OBJECTIVE: Cell-matrix interactions are important regulators of cellular functions, including matrix synthesis, proliferation and differentiation. This is well exemplified by the characteristically labile phenotype of chondrocytes that is lost in monolayer culture but is stabilized in suspension under appropriate conditions. We were interested in the role of collagen suprastructures in maintaining or destabilizing the cartilage phenotype of chondrocytes. DESIGN: Primary sternal chondrocytes from 17-day-old chick embryos were cultured in gels of fibrils reconstituted from soluble collagen I from various sources. The culture media either contained or lacked FBS. Cells were cultured for up to 28 days and the evolution of the phenotype of the cells was assessed by their collagen expression (collagens II and X for differentiated chondrocytes and hypertrophic chodrocytes, repectively; collagen I for phenotypically modulated cells), or by their secretion of alkaline phosphatase (hypertrophic cartilage phenotype). RESULTS: The cells often retained their differentiated phenotype only if cultured with serum. Under serum-free conditions, cartilage characteristics were lost. The cells acquired a fibroblast-like shape and, later, synthesized collagen I instead of cartilage collagens. Shape changes were influenced by beta1-integrin-activity, whereas other matrix receptors were important for alterations of collagen patterns. Heterotypic fibrils reconstituted from collagens II, IX, and XI did not provoke this phenotypic instability. CONCLUSIONS: Chondrocytes sensitively recognize the suprastructures of collagen fibrils in their environment. Cellular interactions with fibrils with appropriate molecular organizations, such as that in cartilage fibrils, result in the maintenance of the differentiated cartilage phenotype. However, other suprastructures, e.g. in reconstituted fibrils mainly containing collagen I, lead to cell-matrix interactions incompatible with the cartilage phenotype. The maintenance of the differentiated traits of chondrocytes is pivotal for the normal function of, e.g., articular cartilage. If pathologically altered matrix suprastructures lead to a dysregulation of collagen production also in vivo compromised cartilage functions inevitably will be propagated further. (+info)Articular cartilage repair using a tissue-engineered cartilage-like implant: an animal study. (2/125)
OBJECTIVE: Because articular cartilage has limited ability to repair itself, treatment of (osteo)chondral lesions remains a clinical challenge. We aimed to evaluate how well a tissue-engineered cartilage-like implant, derived from chondrocytes cultured in a novel patented, scaffold-free bioreactor system, would perform in minipig knees with chondral, superficial osteochondral, and full-thickness articular defects. DESIGN: For in vitro implant preparation, we used full-thickness porcine articular cartilage and digested chondrocytes. Bioreactors were seeded with 20x10(6) cells and incubated for 3 weeks. Subsequent to culture, tissue cartilage-like implants were divided for assessment of viability, formaldehyde-fixed and processed by standard histological methods. Some samples were also prepared for electron microscopy (TEM). Proteoglycans and collagens were identified and quantified by SDS-PAGE gels. For in vivo studies in adult minipigs, medial parapatellar arthrotomy was performed unilaterally. Three types of defects were created mechanically in the patellar groove of the femoral condyle. Tissue-engineered cartilage-like implants were placed using press-fit fixation, without supplementary fixation devices. Control defects were not grafted. Animals could bear full weight with an unlimited range of motion. At 4 and 24 weeks postsurgery, explanted knees were assessed using the modified ICRS classification for cartilage repair. RESULTS: After 3-4 weeks of bioreactor incubation, cultured chondrocytes developed a 700-microm- to 1-mm-thick cartilage-like tissue. Cell density was similar to that of fetal cartilage, and cells stained strongly for Alcian blue and safranin O. The percentage of viable cells remained nearly constant (approximately 90%). Collagen content was similar to that of articular cartilage, as shown by SDS-PAGE. At explantation, the gross morphological appearance of grafted defects appeared like normal cartilage, whereas controls showed irregular fibrous tissue covering the defect. Improved histologic appearance was maintained for 6 months postoperatively. Although defects were not always perfectly level upon implantation at explanation the implant level matched native cartilage levels with no tissue hypertrophy. Once in place, implants remodelled to tissues with decreased cell density and a columnar organization. CONCLUSIONS: Repair of cartilage defects with a tissue-engineered implant yielded a consistent gross cartilage repair with a matrix predominantly composed of type II collagen up to 6 months after implantation. This initial result holds promise for the use of this unique bioreactor/tissue-engineered implant in humans. (+info)COL11A1 in FAP polyps and in sporadic colorectal tumors. (3/125)
BACKGROUND: We previously reported that the alpha-1 chain of type 11 collagen (COL11A1), not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline mutations in the APC gene show, besides colonic polyposis, symptoms of stromal fibroblast involvement, which could be related to COL11A1 expression. Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of beta-catenin. METHODS: We used normal and polyp tissue samples from one FAP patient and a set of 37 sporadic colorectal carcinomas to find out if the up-regulation of COL11A1 was associated with an active APC/beta-catenin pathway. RESULTS: In this study we found a statistically significant difference in COL11A1 expression between normal tissue and adenomas from one FAP patient, and all adenomas gave evidence for an active APC/beta-catenin pathway. An active Wnt pathway has been suggested to involve stromal expression of WISP-1. We found a strong correlation between WISP-1 and COL11A1 expression in sporadic carcinomas. CONCLUSIONS: Our results suggest that expression of COL11A1 in colorectal tumors could be associated with the APC/beta-catenin pathway in FAP and sporadic colorectal cancer. (+info)Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints. (4/125)
OBJECTIVE: The STR/ort mouse strain develops osteoarthritis (OA) of the medial tibial cartilage whilst CBA mice do not develop this disease. We investigated whether changes occur in the expression of genes encoding major extracellular matrix proteins in the connective tissue of the murine knee joint in OA. DESIGN: Expression of the genes encoding collagens II (Col2alpha1), X (Col10alpha1), alpha2(XI) (Col11alpha2) and aggrecan (Agc) was detected in skeletally mature and immature male mice of the CBA and STR/ort strains by in situ hybridization. RESULTS: Col2alpha1 was expressed by chondrocytes of the tibial and patella-femoral cartilage and by the meniscal cartilage in all young mice (4-9 weeks) but only in the patella-femoral cartilage in older mice of both strains (36-45 weeks). In contrast Col2alpha1 was expressed by growth plate chondrocytes of both species at all ages. Similarly, Col2alpha1 transcripts were detected in cruciate ligament cells in both strains at all ages. Col10alpha1 transcripts were detected in cruciate ligament cells in both strains at all ages. Col10alpha1 expression was evident in the hypertrophic chondrocytes in the growth plate of young CBA and STR mice, but was not active in these cells in mature animals. However, Col10alpha1 was transcribed in articular chondrocytes of the tibia, meniscal and patella-femoral cartilages of all ages, in normal and osteoarthritic mice. Transcripts were also present in ligament of some mature animals. Col11alpha2 followed a similar pattern of expression in CBA cartilages to Col2alpha1, being active in adult growth plate but generally inactive in adult articular cartilages. Young CBA and STR/ort mice expressed Col11alpha2 in articular cartilage and very strongly throughout the growth plate. Agc expression was detected in all articular cartilages at all ages in both strains. Interestingly, transcripts for all four genes were absent in tibial articular chondrocytes located close to osteoarthritic lesions in STR/ort mice, indicating that these cells are unable to synthesize matrix proteins. Adult STR/ort mice also showed evidence of tissue remodeling around the periphery of the knee joint. Cells in remodeling areas actively transcribed Col2alpha1, Col10alpha1, Col11alpha2 and Agc. CONCLUSION: It is unlikely that OA develops in STR/ort mice because of failure to express major proteins in joint tissue. However, once lesions develop in articular cartilage neighbouring chondrocytes fail to express genes encoding several matrix proteins. (+info)A Kruppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene. (5/125)
Type XI collagen is composed of three chains, alpha 1(XI), alpha 2(XI), and alpha 3(XI), and plays a critical role in the formation of cartilage collagen fibrils and in skeletal morphogenesis. It was previously reported that the -530-bp promoter segment of the alpha 2(XI) collagen gene (Col11a2) was sufficient for cartilage-specific expression and that a 24-bp sequence from this segment was able to switch promoter activity from neural tissues to cartilage in transgenic mice when this sequence was placed in the heterologous neurofilament light gene (NFL) promoter. To identify a protein factor that bound to the 24-bp sequence of the Col11a2 promoter, we screened a mouse limb bud cDNA expression library in the yeast one-hybrid screening system and obtained the cDNA clone NT2. Sequence analysis revealed that NT2 is a zinc finger protein consisting of a Kruppel-associated box (KRAB) and is a homologue of human FPM315, which was previously isolated by random cloning and sequencing. The KRAB domain has been found in a number of zinc finger proteins and implicated as a transcriptional repression domain, although few target genes for KRAB-containing zinc finger proteins has been identified. Here, we demonstrate that NT2 functions as a negative regulator of Col11a2. In situ hybridization analysis of developing mouse cartilage showed that NT2 mRNA is highly expressed by hypertrophic chondrocytes but is minimally expressed by resting and proliferating chondrocytes, in an inverse correlation with the expression patterns of Col11a2. Gel shift assays showed that NT2 bound a specific sequence within the 24-bp site of the Col11a2 promoter. We found that Col11a2 promoter activity was inhibited by transfection of the NT2 expression vector in RSC cells, a chondrosarcoma cell line. The expression vector for mutant NT2 lacking the KRAB domain failed to inhibit Col11a2 promoter activity. These results demonstrate that KRAB-zinc finger protein NT2 inhibits transcription of its physiological target gene, suggesting a novel regulatory mechanism of cartilage-specific expression of Col11a2. (+info)Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements. (6/125)
Expression of the type XI collagen gene Col11a2 is directed to cartilage by at least three chondrocyte-specific enhancer elements, two in the 5' region and one in the first intron of the gene. The three enhancers each contain two heptameric sites with homology to the Sox protein-binding consensus sequence. The two sites are separated by 3 or 4 bp and arranged in opposite orientation to each other. Targeted mutational analyses of these three enhancers showed that in the intronic enhancer, as in the other two enhancers, both Sox sites in a pair are essential for enhancer activity. The transcription factor Sox9 binds as a dimer at the paired sites, and the introduction of insertion mutations between the sites demonstrated that physical interactions between the adjacently bound proteins are essential for enhancer activity. Additional mutational analyses demonstrated that although Sox9 binding at the paired Sox sites is necessary for enhancer activity, it alone is not sufficient. Adjacent DNA sequences in each enhancer are also required, and mutation of those sequences can eliminate enhancer activity without preventing Sox9 binding. The data suggest a new model in which adjacently bound proteins affect the DNA bend angle produced by Sox9, which in turn determines whether an active transcriptional enhancer complex is assembled. (+info)Collagen XI sequence variations in nonsyndromic cleft palate, Robin sequence and micrognathia. (7/125)
Cleft palate is a common birth defect, but its etiopathogenesis is mostly unknown. Several studies have shown that cleft palate has a strong genetic component. Robin sequence consists of three of the following four findings: micrognathia, glossoptosis, obstructive apnea, and cleft palate. While cleft palate is mainly nonsyndromic, about 80 percent of Robin sequence cases are associated with syndromes. Mutations in genes coding for cartilage collagens II and XI, COL2A1, COL11A1 and COL11A2, have been shown to cause chondrodysplasias that are commonly associated with Robin sequence, micrognathia or cleft palate. We therefore analyzed a cohort of 24 patients with nonsyndromic Robin sequence, 17 with nonsyndromic cleft palate and 21 with nonsyndromic micrognathia for mutations in COL11A2. A total of 23 Robin sequence patients were also analyzed for mutations in COL2A1 and COL11A1. We detected two disease-associated mutations in patients with Robin sequence, an Arg to stop codon mutation in COL11A2 and a splicing mutation in COL11A1. Two putatively disease-associated sequence variations were found in COL11A1 in Robin sequence patients, one in COL11A2 in a patient with micrognathia and one in COL2A1 in two patients with Robin sequence. The results showed that sequence variations in these genes can play a role in the etiology of Robin sequence, cleft palate and micrognathia but are not common causes of these phenotypes. (+info)Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia. (8/125)
Campomelic dysplasia (CD) is a semilethal osteochondrodysplasia, characterized by skeletal anomalies that include bending of the long bones, and by XY sex reversal. CD results from haploinsufficiency for the transcription factor SOX9, a key regulator at various steps of cartilage differentiation and of early testis development. Two functional domains are so far recognized for SOX9, a high-mobility group (HMG) DNA-binding domain and a C-terminal transactivation domain. We present two CD patients with de novo mutations in a conserved region preceding the HMG domain. A long-term survivor with the acampomelic form of CD has an A76E amino acid substitution, while a severely affected CD patient had an in-frame deletion of amino acid residues 66-75. The conserved domain has been shown to function in the related transcription factor SOX10 as a DNA-dependent dimerization domain. We show that, like SOX10, SOX9 also binds cooperatively as a dimer to response elements in regulatory regions of some target genes such as the cartilage genes Col11a2 and CD-Rap. Dimerization and the resulting capacity to activate promoters via dimeric binding sites is lost in both mutant SOX9 proteins while other features involved in SOX9 function remained unaltered. These findings establish the dimerization domain as the third domain essential for SOX9 function during chondrogenesis. (+info)Collagen Type XI is a fibrillar collagen primarily found in the cartilage, consisting of three alpha chains (α1(XI), α2(XI), and α3(XI)) that forms heterotrimers and functions as a minor component in type II collagen fibrils, contributing to their stability and organization.
Collagen type XI is a fibrillar collagen that is found in the extracellular matrix of various tissues, including cartilage and the eye. It is a homotrimer made up of three identical alpha 1(XI) chains or a heterotrimer composed of two alpha 1(XI) chains and one alpha 2(XI) chain. Collagen type XI is closely associated with collagen type II fibrils and plays a role in regulating the diameter and organization of these fibrils. Mutations in the genes encoding collagen type XI can lead to skeletal disorders such as stiff skin syndrome and fibrodysplasia ossificans progressiva.
Collagen is the most abundant structural protein in the extracellular matrix and connective tissues, such as tendons, ligaments, skin, and bones, providing strength, resilience, and support to maintain tissue integrity and regeneration.
Collagen is the most abundant protein in the human body, and it is a major component of connective tissues such as tendons, ligaments, skin, and bones. Collagen provides structure and strength to these tissues and helps them to withstand stretching and tension. It is made up of long chains of amino acids, primarily glycine, proline, and hydroxyproline, which are arranged in a triple helix structure. There are at least 16 different types of collagen found in the body, each with slightly different structures and functions. Collagen is important for maintaining the integrity and health of tissues throughout the body, and it has been studied for its potential therapeutic uses in various medical conditions.
Collagen Type I is the most abundant form of collagen in the human body, primarily found in bone, skin, tendon, ligament, and vascular tissues, composed of two alpha-1 chains and one alpha-2 chain, providing structure, strength, and elasticity to these connective tissues.
Collagen Type I is the most abundant form of collagen in the human body, found in various connective tissues such as tendons, ligaments, skin, and bones. It is a structural protein that provides strength and integrity to these tissues. Collagen Type I is composed of three alpha chains, two alpha-1(I) chains, and one alpha-2(I) chain, arranged in a triple helix structure. This type of collagen is often used in medical research and clinical applications, such as tissue engineering and regenerative medicine, due to its excellent mechanical properties and biocompatibility.
Collagen, type XI, alpha 1
The COL11A1 gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a ... XI) collagen cDNA demonstrates that type XI belongs to the fibrillar class of collagens and reveals that the expression of the ... and XI in the growth plate of human rib and fetal bovine epiphyseal cartilage: type XI collagen is restricted to thin fibrils ... type XI, alpha 1". GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome Yoshioka H, Ramirez F (1990). "Pro-alpha 1(XI) collagen. ...
Collagen, type XI, alpha 2
Type XI collagen also helps maintain the spacing and diameter of type II collagen fibrils. Type II collagen is an important ... Instead, another type of collagen chain replaces pro-alpha2(XI) to form type XI collagen in the vitreous of the eye. COL11A2 ... The COL11A2 gene produces one component of this type of collagen, called the pro-alpha2(XI) chain. Type XI collagen adds ... These mutations prevent the normal assembly of type XI collagen. Type XI collagen plays an important role in the structure and ...
Collagen, type II, alpha 1
... chain of type II collagen. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and ... "A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in ... type 2 by affecting tissues that are rich in type II collagen. Platyspondylic lethal skeletal dysplasia, Torrance type:Fewer ... chain that cannot be incorporated into type II collagen fibers. As a result, cells make a reduced amount of type II collagen. ...
Collagen, type XVII, alpha 1
It encodes the alpha chain of type XVII collagen. Collagen XVII is a transmembrane protein, like collagen XIII, XXIII and XXV. ... which in turn causes a type of osteogenesis imperfecta. Collagen, type XVII, alpha 1 has been shown to interact with Keratin 18 ... Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. Each 180 kD a- ... 2015). "Mutations in collagen, type XVII, alpha 1 (COL17A1) cause epithelial recurrent erosion dystrophy (ERED)". Hum. Mutat. ...
Type IV collagen
Tight collagen helix The most common collagen is type I collagen which makes up 90% of all collagen. It is found in all dermal ... show that the collagen hybridizing peptide probes can be used across species and collagen types (including type IV collagen), ... Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ...
Collagen, type VIII, alpha 1
"Entrez Gene: COL8A1 collagen, type VIII, alpha 1". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major ... Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the ...
Collagen, type VI, alpha 1
"Entrez Gene: COL6A1 collagen, type VI, alpha 1". Bertini E, Pepe G (2002). "Collagen type VI and related disorders: Bethlem ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ... The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that ... 1996). "Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures". Nat. Genet. 14 (1): ...
Collagen, type XIII, alpha 1
Latvanlehto A, Snellman A, Tu H, Pihlajaniemi T (2003). "Type XIII collagen and some other transmembrane collagens contain two ... Collagen XIII belongs to the transmembranous subfamily of collagens, like collagen XVII, XXIII and XXV. GRCh38: Ensembl release ... 2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and ... 1998). "Type XIII collagen is identified as a plasma membrane protein". J. Biol. Chem. 273 (25): 15590-7. doi:10.1074/jbc. ...
Collagen, type XV, alpha 1
Type XV collagen is known to be a tumor suppressor that can be used to understand tumor cells environment. Type XV collagen ... This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with ... "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed ... Hägg PM, Hägg PO, Peltonen S, Autio-Harmainen H, Pihlajaniemi T (June 1997). "Location of type XV collagen in human tissues and ...
Collagen, type IX, alpha 1
Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. ... "Entrez Gene: COL9A1 collagen, type IX, alpha 1". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...
Collagen, type III, alpha 1
... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... type III collagen is also an important regulator of the diameter of type I and II collagen fibrils. Type III collagen is also ... Type III collagen could also be important in several other human diseases. Increased amounts of type III collagen are found in ... Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain. Type III ...
Collagen, type XXV, alpha 1
"Entrez Gene: COL25A1 collagen, type XXV, alpha 1". Kakuyama H, Söderberg L, Horigome K, et al. (2006). "CLAC binds to ... Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein. GRCh38: Ensembl release 89: ... CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524-34. doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537. " ... Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene. COL25A1 is a brain-specific membrane- ...
Collagen, type XIX, alpha 1
This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with ... other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve ... collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics ... "Entrez Gene: COL19A1 collagen, type XIX, alpha 1". Yoshioka H, Zhang H, Ramirez F, et al. (1992). "Synteny between the loci for ...
Collagen, type VI, alpha 2
"Entrez Gene: COL6A2 collagen, type VI, alpha 2". "COLLAGEN, TYPE VI, ALPHA-2; COL6A2". www.omim.org. Retrieved 2023-10-13. ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ... This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective ... 1996). "Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures". Nat. Genet. 14 (1): ...
Collagen, type IV, alpha 1
It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in ... collagen". FEBS Letters. 225 (1-2): 188-94. doi:10.1016/0014-5793(87)81155-9. PMID 3691802. "Entrez Gene: COL4A1 collagen, type ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S ...
Type V collagen
... is a part of the family of collagen proteins consisting of Collagen I- Collagen XXVIII. Collagen proteins are ... type V collagen preproprotein, CO5A1_HUMAN, and collagen type V alpha. Type V collagen can also be abbreviated to COLV or ... Type V collagen is a part of the Extracellular Matrix (ECM). Collagen V is gene expression modulated by TGF-β. Type V collagen ... Together, Collagen V and Collagen I acts as a dominant regulator of collagen fibrillogenesis. Type V Collagens interacts with ...
Collagen, type XII, alpha 1
... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... "Entrez Gene: COL12A1 collagen, type XII, alpha 1". "Collagen, Type XII, Alpha-1; COL12A1 Gene-Phenotype Relationships". Online ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics ...
Collagen, type XVIII, alpha 1
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ... 2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are ... "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to ... "Entrez Gene: COL18A1 collagen, type XVIII, alpha 1". Pufe T, Kurz B, Petersen W, et al. (2006). "The influence of biomechanical ...
Collagen, type V, alpha 3
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ... Kypreos KE, Sonenshein GE (1998). "Basic fibroblast growth factor decreases type V/XI collagen expression in cultured bovine ...
Ullrich congenital muscular dystrophy
UCMD1 is associated with variants of type VI collagen, while UCMD2 is associated with variants of type XII collagen. UCMD is ... "COL6A1 collagen type VI alpha 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-05-11. Bushby KM, ... Alpha 1 subunit of type VI collagen is the encoded protein. In terms of the genetics of UCMD2, there are mutations in the gene ... Collagen type VI myopathies. Adv Exp Med Biol 802:185-199 Reed, Umbertina Conti; Ferreira, Lucio Gobbo; Liu, Enna Cristina; ...
Collagen disease
Collagenopathy, types II and XI Connective tissue disease Coburn, Alvin (1974). Commitment Total. United States of America: ... 54, xi. ISBN 0-8027-0449-2. Collagen disease entry in the public domain NCI Dictionary of Cancer Terms This article ... Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus ... "collagen disease" was coined by Dr. Alvin F. Coburn in 1932, on his quest to discover streptococcal infection as the cause for ...
Type XXVII collagen
It is related to the fibrillar collagens: type II, type XI, and type XXIV. Current research suggests that it is made by ... Type XXVII collagen is the protein predicted to be encoded by COL27A1. It was first described by Dr. James M. Pace and his ... v t e (Articles lacking sources from December 2009, All articles lacking sources, Collagens, All stub articles, Protein stubs) ...
Collagen
The number of types shows collagen's diverse functionality. Fibrillar (Type I, II, III, V, XI) Non-fibrillar FACIT (Fibril ... of the collagen in the human body is type I collagen. However, as of 2011, 28 types of human collagen have been identified, ... Type XIII, XVII) Microfibril forming (Type VI) Anchoring fibrils (Type VII) The five most common types are: Type I: skin, ... With type I collagen and possibly all fibrillar collagens, if not all collagens, each triple-helix associates into a right- ...
Collagen, type IX, alpha 3
Perälä M, Savontaus M, Metsäranta M, Vuorio E (1997). "Developmental regulation of mRNA species for types II, IX and XI ... Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ...
Collagen, type V, alpha 1
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... "Entrez Gene: COL5A1 collagen, type V, alpha 1". Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ...
Myocardial infarction diagnosis
Enhanced deposition of predominantly type I collagen in myocardial disease. J Mol Cell Cardiol. 1990;22:1157-1165 Table 11-2 in ... Clinical history of ischaemic type chest pain lasting for more than 20 minutes Changes in serial ECG tracings Rise and fall of ... have nearly complete tissue specificity and are now the preferred markers for assessing myocardial damage.Heart-type fatty acid ... Archived 2015-11-21 at the Wayback Machine)" Chute, Michael; Aujla, Preetinder; Jana, Sayantan; Kassiri, Zamaneh (2019). "The ...
Ehlers-Danlos syndromes
Diagnostic tests include collagen gene-variant testing, collagen typing via skin biopsy, echocardiogram, and lysyl hydroxylase ... type 5 130080: type 8 - unspecified gene, locus 12p13 225310: type 10 - unspecified gene, locus 2q34 608763: Beasley-Cohen type ... It has two types. Type 1 occurs due to variations in the ZNF469 gene. Type 2 is due to variations in the PRDM5 gene. Classical- ... Except for hypermobility (type 3), the most common type of all 10 types, some of the specific variations involved have been ...
Weissenbacher-Zweymüller syndrome
The COL11A2 gene is responsible for providing instructions on making one component of the type XI collagen. Type XI collagen is ... which codes for the α2 strand of collagen type XI. It is a collagenopathy, types II and XI disorder. The condition was first ... The mutation of COL11A2 in Weissenbacher-Zweymüller syndrome disrupts the assembly of the type XI collagen molecules. The ... Collagen is found in bone. It is also found in cartilage that makes up most of the skeleton during early development. ...
Nanofiber
Using type I collagen nanofibers produced via electrospinning, Shih et al. found that the engineered collagen scaffold showed ... Shih YR, Chen CN, Tsai SW, Wang YJ, Lee OK (November 2006). "Growth of mesenchymal stem cells on electrospun type I collagen ... Nonmineralized organic component (i.e. type 1 collagen), mineralized inorganic component (i.e. hydroxyapatite), and many other ... PCL is a type of biodegradable polyester that can be prepared via ring-opening polymerization of ε-caprolactone using catalysts ...
Alpha collagen
Collagen, type I, alpha 1 Collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ... collagen (type I, II, VI, X collagen fibrils) and proteoglycans. The ratio and the proportion of collagen play an important ... "Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen". Cell and ...
Collagen, type XI, alpha 1 - Wikipedia
The COL11A1 gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a ... XI) collagen cDNA demonstrates that type XI belongs to the fibrillar class of collagens and reveals that the expression of the ... and XI in the growth plate of human rib and fetal bovine epiphyseal cartilage: type XI collagen is restricted to thin fibrils ... type XI, alpha 1". GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome Yoshioka H, Ramirez F (1990). "Pro-alpha 1(XI) collagen. ...
Human COL11a2(Collagen Type XI Alpha 2) ELISA Kit - UNICO Microscopes and Spectrophotometers
Human COL11a2(Collagen Type XI Alpha 2) ELISA Kit. Human COL11a2(Collagen Type XI Alpha 2) ELISA Kit ... Human Collagen Type XI Alpha 1 (COL11a1) ELISA Kit. SEC157Hu-10x96wellstestplate Cloud-Clone 10x96-wells test plate. 5677.8 EUR ... Description: A sandwich ELISA kit for detection of Collagen Type XI Alpha 2 from Human in samples from blood, serum, plasma, ... Description: A sandwich ELISA kit for detection of Collagen Type XI Alpha 1 from Human in samples from blood, serum, plasma, ...
Collagen Type - Friday Pop Quiz 11/4/2022 - Next Steps in Dermatology
![COL2A1 collagen type II alpha 1 chain [Homo sapiens (human)] - Gene - NCBI](data:image/png;base64,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)
COL2A1 collagen type II alpha 1 chain [Homo sapiens (human)] - Gene - NCBI
part_of collagen type XI trimer NAS Non-traceable Author Statement. more info ... COL2A1 collagen type II alpha 1 chain [Homo sapiens] COL2A1 collagen type II alpha 1 chain [Homo sapiens]. Gene ID:1280 ... alpha-1 type II collagen. arthroophthalmopathy, progressive (Stickler syndrome). cartilage collagen. chondrocalcin. collagen II ... Collagen; Collagen triple helix repeat (20 copies). pfam00093. Location:34 → 89. VWC; von Willebrand factor type C domain. ...
HKU Scholars Hub: The gene for the α2 chain of the human fibrillar collagen type XI (COL11A2) assigned to the short arm of...
... which is in accordance with the classification of type XI collagen as a fibrillar collagen. The genomic clone containing the α2 ... which is in accordance with the classification of type XI collagen as a fibrillar collagen. The genomic clone containing the α2 ... The gene for the α2 chain of the human fibrillar collagen type XI (COL11A2) assigned to the short arm of chromosome 6. en_US. ... Article: The gene for the α2 chain of the human fibrillar collagen type XI (COL11A2) assigned to the short arm of chromosome 6 ...
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Glycoprotein VI deficiency: MedlinePlus Genetics
Bleeding diathesis due to a collagen receptor defect. *Bleeding disorder, platelet-type, 11 ... to another protein called collagen that is found on blood vessel walls. . The binding of GPVI to collagen also signals ... or a protein that is less able to bind to collagen. Without GPVI binding to collagen, platelets cannot come together ... Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood. 2009 Aug 27;114(9):1900- ...
Col6a4 MGI Mouse Gene Detail - MGI:1915803 - collagen, type VI, alpha 4
COL15A1 collagen type XV alpha 1 chain [Homo sapiens (human)] - Gene - NCBI
collagen alpha-1(XV) chain. Names. collagen XV, alpha-1 polypeptide. collagen type XV proteoglycan. collagen, type XV, alpha 1 ... COL15A1 collagen type XV alpha 1 chain [Homo sapiens] COL15A1 collagen type XV alpha 1 chain [Homo sapiens]. Gene ID:1306 ... This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with ... the crystal structure of the trimerization domain of human type XV collagen Title: Crystal structure of the human collagen XV ...
Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects
... type II, type IX, and type XI collagen; decorin; cartilage oligomeric matrix protein; COMP; scleraxis). ... BMAC treatment also yielded a significantly increased type II collagen and glycosaminoglycan contents with improved collagen ... Outerbridge types III or IV [75]) undergoing microfracture in combination with implantation of a type I/III porcine collagen ... type I collagen; bone sialoprotein (BSP); osteopontin (OPN); osteocalcin (OCN); calcium-rich mineralized matrix). ...
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in...
In type 1 diabetes, multiple AGEs are associated with IMT progression in spite of adjustment for A1c implying a likely ... Skin collagen AGE measurements obtained from stored specimens were related to clinical data from the DCCT/EDIC using Spearman ... Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in ... Erratum to: Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular ...
![Reactome | 4-Hyp 5-Gal-Hyl-collagen alpha-1(XI) chain N-term fragment [extracellular region]](data:image/png;base64,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)
Reactome | 4-Hyp 5-Gal-Hyl-collagen alpha-1(XI) chain N-term fragment [extracellular region]
Collagen degradation (Homo sapiens) * Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens) * Cleaved collagen type XI ... Cleaved collagen type XI fibril [extracellular region] (Homo sapiens) * Cleaved tropocollagen type XI [extracellular region] ( ... Cleaved collagen type XI fibril [extracellular region] (Homo sapiens) * Cleaved tropocollagen type XI [extracellular region] ( ... Cleaved tropocollagen type XI [extracellular region] (Homo sapiens) * Cleaved collagen alpha-1(XI) chains [extracellular region ...
Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts
Many studies have evaluated the relationship between AA and collagen expression in short- and long-term effects on cells after ... is essential for collagen biosynthesis as a cofactor for prolyl and lysyl hydroxylase and as a stimulus for collagen gene ... the expression of type 1 and type 4 collagens and SVCT2 mRNA was enhanced, and type 1 procollagen synthesis increased. Thus, ... Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts Biochem ...
Col6a5 MGI Mouse Gene Detail - MGI:3648134 - collagen, type VI, alpha 5
What Is Your Diagnosis? in: Journal of the American Veterinary Medical Association Volume 257 Issue 11 ()
Expression of the α6 chain of type IV collagen in glomerular basement membranes of healthy adult dogs ... Expression of the α6 chain of type IV collagen in glomerular basement membranes of healthy adult dogs ... 11. Marino G, Barna A, Rizzo S, et al. Endometrial polyps in the bitch: a retrospective study of 21 cases. J Comp Pathol 2013; ... 11. Marino G, Barna A, Rizzo S, et al. Endometrial polyps in the bitch: a retrospective study of 21 cases. J Comp Pathol 2013; ...
JCI - Adipocyte-derived endotrophin promotes malignant tumor progression
Collagen type VI (COL6; encoded by Col6a1, Col6a2, and Col6a3) is ubiquitously expressed throughout connective tissues, such as ... Specks U, Nerlich A, Colby TV, Wiest I, Timpl R. Increased expression of type VI collagen in lung fibrosis. Am J Respir Crit ... Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling. Am J Physiol Heart ... Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. Collagen VI ( ...
Health and Wellness Archives - Page 2 of 11 - Ideal Image Medspa
MMRRC:040105-MU
Name: collagen, type XI, alpha 2. Type: Gene. Species: Mus musculus (mouse) ... When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J ... Name: Tax1 (human T cell leukemia virus type I) binding protein 3 ... Name: membrane associated ring-CH-type finger 2. Synonyms: ...
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Ehlers-Danlos Syndrome with Ellen Smith 12/11 by Coach Marla | Health
Each type of EDS is a distinct disorder that runs true in a family. This means that an individual with vascular Type EDS will ... The fragile skin and unstable joints found in EDS are the result of faulty collagen. Collagen is a protein, which acts as a ... There are six major types of EDS. The different types of EDS are classified according to their manifestations of signs and ... not have a child with Classical Type EDS. Learn More: Ehlers-Danlos National Foundation OR Invisible Project Also, Drug ...
Relapsing Polychondritis Clinical Presentation: History, Physical Examination
Collagen types II, IX, and XI are found in the cornea and sclera. Autoantibodies to these collagens, which are found in ... Antibodies to type II collagen in relapsing polychondritis. N Engl J Med. 1978 Nov 30. 299(22):1203-7. [QxMD MEDLINE Link]. ... Type II collagen-induced auricular chondritis. Arthritis Rheum. 1982 Mar. 25(3):266-73. [QxMD MEDLINE Link]. ... Two types of MAGIC syndrome exist. [43] The more common type begins with the oral and genital ulcers of Behçet disease. The ...
Reactome | 3,4-Hyp 5-Gal-Hyl-collagen alpha-2(XI) chain C-term fragment [extracellular region]
Collagen degradation (Homo sapiens) * Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens) * Cleaved collagen type XI ... Cleaved collagen type XI fibril [extracellular region] (Homo sapiens) * Cleaved tropocollagen type XI [extracellular region] ( ... Cleaved collagen type XI fibril [extracellular region] (Homo sapiens) * Cleaved tropocollagen type XI [extracellular region] ( ... Cleaved tropocollagen type XI [extracellular region] (Homo sapiens) * Cleaved collagen alpha-2(XI) chains [extracellular region ...
US11702447B2 - Methods for producing collagen - Google Patents
Still further, the collagen produced by the methods described herein is suitable to be used in cosmetics, food products, and ... Further, the collagen produced by the methods described herein is substantially free of odor and discoloration. ... Disclosed herein are methods for efficiently isolating collagen form a collagen source. The methods are inexpensive and do not ... Fibrillar types of collagen include Types I, II, III, V, and XI. Type I collagen makes up a great deal of the organic part of ...
RCSB PDB - 3IPN: Crystal Structure of fluorine and methyl modified collagen: (mepFlpgly)7
Crystal Structure of fluorine and methyl modified collagen: (mepFlpgly)7 ... Type. Formula. 2D Diagram. Parent. FP9. Query on FP9. A, B, C, D, E ... Replacing proline residues in (ProProGly)(7) collagen strands with 4-fluoroproline and 4-methylproline leads to the most stable ... Crystal Structure of fluorine and methyl modified collagen: (mepFlpgly)7. *PDB DOI: https://doi.org/10.2210/pdb3IPN/pdb ...
Recurrence of Achilles tendon injuries in elite male football players is more common after early return to play: an 11-year...
Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesis. Exerc Sport Sci Rev 2011;39:191-8. ... Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis. Scand J ... Types and epidemiology of tendinopathy. Clin Sports Med 2003;22:675-92. ... These sudden changes in intensity, training load and training type are suggested to be risk factors for overuse injuries such ...
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UC-II Collageen Type 2 40 mg met aquamin 60 vegicaps ... Undenatured Type II Collagen 60 veggie caps. UC-II, Undenatured ... Collageen poeder met Hyaluronzuur & Elastine , Collagen hydrolysaat peptide type I, II en III van weidebouw , zonder ... 11 months. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the ... 11 months. This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in ...
Relapsing Polychondritis: Practice Essentials, Background, Pathophysiology
... types IX and XI) have been described. They are more likely to be found in association with antibodies to type II collagen in ... Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of ... cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive ... Antibodies to type II collagen in relapsing polychondritis. N Engl J Med. 1978 Nov 30. 299(22):1203-7. [QxMD MEDLINE Link]. ...
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ProteinFibrillar collagen2018DegradationCOL11A2Changes in collagenTumorRelapsing polychondritisCartilage-specific2023FibroblastsAntibodiesTissuesReceptorsGelatinMRNAConnective tissueGeneticVascularExtracellularProteinsRecombinantGene expressionWorld'sMETHODSDeficiencyAntibodyCellsDeteriorationInflammationFiberAlphaMutationFibroblastAbundantPotentiallyHumanPowderMigrationMarkersCellMutationsFoundSkinElasticityHumans
Protein13
- Collagen alpha-1(XI) chain is a protein that in humans is encoded by the COL11A1 gene. (wikipedia.org)
- In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. (nih.gov)
- In response to an injury that causes bleeding, the GPVI protein begins clot formation by attaching (binding) to another protein called collagen that is found on blood vessel walls . (medlineplus.gov)
- or a protein that is less able to bind to collagen. (medlineplus.gov)
- The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. (nih.gov)
- Collagen is the most abundant structural protein in the human body. (shopclues.com)
- 1/3 of total body-protein content & 2/3 of the skin is Collagen. (shopclues.com)
- Collagen is a protein, which acts as a 'glue' in the body, adding strength and elasticity to connective tissue. (blogtalkradio.com)
- Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. (biomedcentral.com)
- d - i Type IV collagen protein and mRNA expression in the lung. (biomedcentral.com)
- [1] Typically, these variations result in defects in the structure or processing of the protein collagen . (wikipedia.org)
- Hesp, who also serves at the company's Head of Science, says there's little point in developing an alternative to collagen protein. (forbes.com)
- Collagen is a very complex protein and the founders don't want to spend extra time engineering other systems to do what cells do naturally. (forbes.com)
Fibrillar collagen3
- The COL11A1 gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. (wikipedia.org)
- This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. (nih.gov)
- The gene contains conserved DNA and amino-acid sequences characteristic of fibril forming collagen, which is in accordance with the classification of type XI collagen as a fibrillar collagen. (hku.hk)
20182
- Ehlers-Danlos syndromes ( EDS ) are a group of 13 genetic connective-tissue disorders in the current classification, [7] with the latest type discovered in 2018. (wikipedia.org)
- Two health specialists from CDC and UNHCR conducted an outbreak investigation during March 11-17, 2018. (cdc.gov)
Degradation4
- One such target for aging reversal is collagen degradation or turnover. (dovepress.com)
- 1 One of the most important molecular mechanisms that cause the physical signs of aging is enzymatic degradation of collagen and elastin. (dovepress.com)
- Stultz CM., Insight into the Degradation of Type-I Collagen Fibrils by MMP-8. (mit.edu)
- Serum markers of collagen degradation, collagen synthesis, and their ratio were not elevated in aged rats with task performance. (cdc.gov)
COL11A22
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Collagen Type XI Alpha 2 (COL11a2) in serum, plasma, tissue homogenates and other biological fluids. (unicoupi.com)
- A cosmid clone (CosHcol.11) containing the α2(XI) collagen gene (COL11A2) has been isolated. (hku.hk)
Changes in collagen2
- Recessive dystrophic epidermolysis bullosa (RDEB) is a severe subtype of epidermolysis bullosa caused by changes in collagen VII with a high risk of early development of cutaneous squamous cell carcinoma (cSCC). (thieme-connect.de)
- These values, normalized to a color scale displaying the ultrasound image, will allow for a comparative analysis of changes in collagen and elastin fiber content in the dermis. (who.int)
Tumor3
- Tumor suppression by collagen XV is independent of the restin domain. (nih.gov)
- Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
- Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
Relapsing polychondritis3
- Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of patients with relapsing polychondritis. (medscape.com)
- Researchers have found that antibodies to type II collagen are present during acute relapsing polychondritis episodes and that the levels correlate with the severity of the episode. (medscape.com)
- They are more likely to be found in association with antibodies to type II collagen in patients with relapsing polychondritis. (medscape.com)
Cartilage-specific1
- Autoantibodies to minor cartilage-specific collagens (ie, types IX and XI) have been described. (medscape.com)
20232
- J Mater Chem B;11(38): 9260-9275, 2023 10 06. (bvsalud.org)
- 11(38): 9260-9275, 2023 10 06. (bvsalud.org)
Fibroblasts2
- Thus, these results indicate that human skin fibroblasts exposed to AA over time had rising levels of type 1/type 4 collagens and SVCT2 mRNA expression and type 1 procollagen synthesis. (nih.gov)
- They are found on a wide variety of cell types including, T cells (the NKT cells ), NK cells , fibroblasts and platelets . (wikidoc.org)
Antibodies1
- Antibodies mediated towards what collagen type leads to the condition depicted in the image? (nextstepsinderm.com)
Tissues2
- My group uses 3D imaging of healthy and diseased tissues to understand what makes them different, how this changes between types of tissue and species, and how to recreate this in a 3D biomaterial for application to disease modelling. (nottingham.ac.uk)
- 1% sodium bicarbonate (NaHCO ) dis- ions in tissues such as collagen or muscle. (who.int)
Receptors1
- This review highlights the genes and genetic polymorphisms currently studied, identified as influential in the genesis of IS, such as MMP-3, IL-6, type I collagen, and vitamin D and estrogen receptors. (scielo.br)
Gelatin6
- Research was done to process the solid wastes into collagen fibrous networks such as nonwoven mats, which were then mixed with gelatin and molded into fiber-reinforced composites. (usda.gov)
- Currently in the lab, we are photo-crosslinking unmodified Type 1 collagen, silk fibroin and gelatin, using a cell phone torch! (otago.ac.nz)
- Versatile, animal-derived proteins like collagen and gelatin are common-place in packaged foods, cosmetics, and even pharmaceuticals. (forbes.com)
- There's no substitute for collagen and gelatin," says Hesp. (forbes.com)
- If we can optimize each step of [collagen development] we can create a [greater], more functional yield of higher quality collagen and gelatin," says Michelsen. (forbes.com)
- 21). Gelatin gels are built from collagen-like triple-helical junction zones, 100 -200 residues in length, connected by flexible single chains (22). (lu.se)
MRNA1
- the expression of type 1 and type 4 collagens and SVCT2 mRNA was enhanced, and type 1 procollagen synthesis increased. (nih.gov)
Connective tissue3
- Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. (nih.gov)
- Collagen found in connective tissue is usually of type I, II, III, V or XI. (liveinternet.ru)
- [17] hEDS is the most common of the 19 types of connective tissue disorders. (wikipedia.org)
Genetic2
- Estimates of the different types of genetic deafness exceed 400, and to date, 60 genes for syndromic and nonsyndromic hearing loss have been identified. (nature.com)
- Molecular genetic tests are available for many types of syndromic and nonsyndromic deafness, although often only on a research basis. (nature.com)
Vascular3
- This means that an individual with vascular Type EDS will not have a child with Classical Type EDS. (blogtalkradio.com)
- The vascular closure devices market is segmented based on type, access, procedure, and region. (researchandmarkets.com)
- Based on type, the vascular closure devices market is segmented into passive approximators, active approximators, and external hemostatic devices. (researchandmarkets.com)
Extracellular2
- 4 Heterologous type I collagen (HTIC) has been shown to promote cell and fibroblast proliferation and improve cutaneous extracellular matrix metabolism. (jcadonline.com)
- She completed her PhD in medical materials at the University of Cambridge in 2015, creating collagen materials to characterise the link between extracellular matrix and cell invasion, in collaboration with Geistlich Pharma AG, Switzerland. (nottingham.ac.uk)
Proteins1
- This sense of urgency is also why Michelsen and Hesp have decided on a cell-based approach rather than expressing collagen proteins through microbes or cell-free technology. (forbes.com)
Recombinant3
- Recombinant human collagen XV regulates cell adhesion and migration. (nih.gov)
- Postfunctionalization of biological valve leaflets with a polyphenol network and anticoagulant recombinant humanized type III collagen for improved anticoagulation and endothelialization. (bvsalud.org)
- Here, a postfunctionalization strategy was established for GLUT-crosslinked BHVs, which were firstly modified with metal -phenolic networks (MPNs) to shield the exposed calcification site, and then anticoagulant recombinant humanized type III collagen (rhCOLIII) was immobilized to endow them with long-term antithrombogenicity and enhanced endothelialization properties. (bvsalud.org)
Gene expression4
- Ascorbic acid (AA) is essential for collagen biosynthesis as a cofactor for prolyl and lysyl hydroxylase and as a stimulus for collagen gene expression. (nih.gov)
- Moreover, we determined the effects on type 1 and type 4 collagen and sodium-dependent vitamin C transporter (SVCT) gene expression when medium containing 100 μM AA was replaced every 24h for 5 days to avoid depletion of AA. (nih.gov)
- Gene expression was assessed by qPCR for muscarinic receptor types 2 (M2) and 3 (M3), collagen type 1α1 and 3α1, and SM actin. (lu.se)
- Results: Bilateral pelvic nerve injury caused larger bladders with less SM content and increased collagen type 1α1 and 3α1 gene expression. (lu.se)
World's1
- INJA Life is the world's BEST Marine (Fish) Collagen, having 8 out of the 9 essential amino acids and 3 non-essential amino acids, besides various conditional amino acids. (shopclues.com)
METHODS2
- We investigated the emergence, dissemination, and diver- totaling 4,973 square miles (12,882 km2), is the border re- sity of MRSA clones in the EMR by using several typing methods. (cdc.gov)
- Methods A total of 27 clubs from 10 countries and 1743 players have been followed prospectively during 11 seasons between 2001 and 2012. (bmj.com)
Deficiency3
- Without GPVI binding to collagen, platelets cannot come together efficiently to form a clot, leading to the bleeding problems associated with glycoprotein VI deficiency. (medlineplus.gov)
- Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. (nih.gov)
- That alterations of collagen VII result in blister formation, scar deficiency associated with inflammation, and increased expression of transforming growth factor β. (thieme-connect.de)
Antibody2
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Collagen Type XI Alpha 1 (COL11a1) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (unicoupi.com)
- The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
Cells4
- Blue cells = expressed in wild-type. (jax.org)
- Many studies have evaluated the relationship between AA and collagen expression in short- and long-term effects on cells after a single administration of AA into the culture medium. (nih.gov)
- Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells . (wikidoc.org)
- We just harvest the collagen from the cells instead of the animals," Michelsen says. (forbes.com)
Deterioration1
- A substantial reduction in the amount and quality of collagen leads to age-related deterioration of the elasticity and firmness of the skin. (dovepress.com)
Inflammation2
- It has been reported in previous studies to have beneficial effects in various inflammatory conditions, such as inflammatory bowel disease, collagen-induced arthritis and lipopolysaccharide (LPS)-induced gingival inflammation. (nutraingredients-usa.com)
- and 11 cytokines/chemokines, markers of inflammation. (cdc.gov)
Fiber2
- We hypothesize collagen fiber networks derived from un-tanned hides can be utilized to prepare high performance green composites and air filters, of which both have a great market potential. (usda.gov)
- Collagen fiber networks were obtained from split hides that have been processed to remove the noncollagenous materials through the hair removal, liming, and bating steps. (usda.gov)
Alpha4
- Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. (wikipedia.org)
- Pro-alpha 1(XI) collagen. (wikipedia.org)
- Description: A sandwich ELISA kit for detection of Collagen Type XI Alpha 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (unicoupi.com)
- This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). (nih.gov)
Mutation1
- Stickler syndrome, type II is an autosomal dominant condition caused by a mutation in the COL11A1 gene. (wikipedia.org)
Fibroblast1
- Optimising collagen scaffold architecture for enhanced periodontal ligament fibroblast migration Journal of Materials Science: Materials in Medicine. (nottingham.ac.uk)
Abundant1
- Variety I is the most abundant, accounting for 90% of all collagen in the body. (liveinternet.ru)
Potentially1
- The ability to control production at the cellular level means the company could potentially design novel collagen types or combinations. (forbes.com)
Human4
- The genomic clone containing the α2(XI) gene has been used as probe in the Southern blot analysis of DNA from a panel of human/hamster somatic cell hybrids containing different numbers and combinations of human chromosomes. (hku.hk)
- Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis. (nih.gov)
- Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens. (nih.gov)
- To study the effect of tap water `softening' (i.e. calcium extraction) on H&E stains, 5 sets of slides from 30 different paraffin-embedded human pathologic tissue blocks were prepared in the same way except for washing with 5 different types of water. (who.int)
Powder1
- Bluebonnet's Hydrolyzed Collagen Powder is carefully crafted to revive hair, skin and nails as part of a daily beauty regimen with collagen peptides types I & III that are sourced form grass-fed cows. (vitacost.com)
Migration1
- In addition to its role in the formation of epithelium and vasculature, type IV collagen appears to be key for alveolar myofibroblast development by inducing their proliferation, differentiation and migration throughout the developing septum. (biomedcentral.com)
Markers1
- We recently reported strong associations between eight skin collagen AGEs and two solubility markers from skin biopsies obtained at DCCT study closeout and the long-term progression of microvascular disease in EDIC, despite adjustment for mean glycemia. (sens.org)
Cell2
- Towards Cellular Sieving: Exploring the Limits of Scaffold Accessibility for Cell Type Specific Invasion Advanced Biosystems. (nottingham.ac.uk)
- This mask is clinically proven to help with cell reproduction, promote collagen production and. (szepelet.com)
Mutations2
- Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. (wikipedia.org)
- Characteristics of a Three-Generation Family with Stickler Syndrome Type I Carrying Two Different COL2A1 Mutations. (nih.gov)
Found1
- The fragile skin and unstable joints found in EDS are the result of faulty collagen. (blogtalkradio.com)
Skin7
- Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes. (sens.org)
- Skin collagen AGE measurements obtained from stored specimens were related to clinical data from the DCCT/EDIC using Spearman correlations and multivariable logistic regression analyses. (sens.org)
- Collagen is like the fountain of youth - it provides skin with firmness, elasticity and a beautiful glow. (idealimage.com)
- Recommended for all skin types, this fragrance-free gel cleanser is clinically proven to easily but gently remove (even waterproof) makeup, eye makeup, dirt and impurities. (szepelet.com)
- Skin renewal mask for all skin types with retinal that acts 11 times faster than Retinol. (szepelet.com)
- The ultimate concentrated skin quencher for normal to oily, acne prone skin types or hyperpigmentation with two types of hyaluronic acid, vitamins and antioxidants for immediate hydration, and skin. (szepelet.com)
- Improving aging skin density and thickness by injecting different types of autologous plasma preparations. (who.int)
Elasticity1
- Collagen peptides help to replenish nutrients lost over time by boosting collagen production, which helps to strengthen hair and nails while supporting the skin's hydration balance and elasticity to counteract visible signs of aging. (vitacost.com)
Humans1
- Different animals produce different collagen, from humans to pigs to jellyfish. (forbes.com)
