Coccidioidomycosis: Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN.Coccidioides: A mitosporic fungal genus which causes COCCIDIOIDOMYCOSIS.ArizonaFungal Vaccines: Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.Coccidioidin: A sterile solution containing the by-products of growth products of COCCIDIOIDES IMMITIS, injected intracutaneously as a test for COCCIDIOIDOMYCOSIS.Lung Diseases, Fungal: Pulmonary diseases caused by fungal infections, usually through hematogenous spread.Antibodies, Fungal: Immunoglobulins produced in a response to FUNGAL ANTIGENS.Antigens, Fungal: Substances of fungal origin that have antigenic activity.Naval Medicine: The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Blastomycosis: A fungal infection that may appear in two forms: 1, a primary lesion characterized by the formation of a small cutaneous nodule and small nodules along the lymphatics that may heal within several months; and 2, chronic granulomatous lesions characterized by thick crusts, warty growths, and unusual vascularity and infection in the middle or upper lobes of the lung.Dermatomycoses: Superficial infections of the skin or its appendages by any of various fungi.Southwestern United States: The geographic area of the southwestern region of the United States. The states usually included in this region are Arizona, California, Colorado, Nevada, New Mexico, Texas, and Utah.Histoplasmosis: Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. It is worldwide in distribution and particularly common in the midwestern United States. (From Dorland, 27th ed)Endemic Diseases: The constant presence of diseases or infectious agents within a given geographic area or population group. It may also refer to the usual prevalence of a given disease with such area or group. It includes holoendemic and hyperendemic diseases. A holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). A hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. (Last, A Dictionary of Epidemiology, 3d ed, p53, 78, 80)Archaeology: The scientific study of past societies through artifacts, fossils, etc.Complement Fixation Tests: Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.Meningitis, Fungal: Meningitis caused by fungal agents which may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.

*  Coccidioidomycosis | St. Petersburg General Hospital | St. Petersburg, FL

Learn more about Coccidioidomycosis at St. Petersburg General Hospital DefinitionCausesRisk ... Hospitalizations for coccidioidomycosis at forty-one children's hospitals in the United States. Pediatr Infect Dis J. 2010;29(3 ... The public health impact of coccidioidomycosis in Arizona and California. Int J Environ Res Public Health. 2011;8(4):1150-1173. ... Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosis. Clin Infect Dis. 2009;48(2): ...
stpetegeneral.com/hl/?/200994/sp

*  Most recent papers with the keyword Mycoses | Read by QxMD

Coccidioidomycosis Involving Lungs and Skin: A Mimicker of Metastatic Disease.. Barbara Saenz-Ibarra, Victor G Prieto, Carlos A ... Coccidioidomycosis is the major systemic mycoses, considered to be 1 of the most infectious fungal diseases. In symptomatic ... Disseminated disease occurs in 1%-5% of all patients affected by coccidioidomycosis and can affect any organ, with the skin, ... https://www.readbyqxmd.com/read/28857979/coccidioidomycosis-involving-lungs-and-skin-a-mimicker-of-metastatic-disease ...
https://readbyqxmd.com/keyword/57069

*  Treatment | Coccidioidomycosis | Types of Fungal Diseases | Fungal | CDC

In many cases, treatment for coccidioidomycosis is not necessary, as symptoms can resolve on their own. Many healthcare ...
https://cdc.gov/fungal/diseases/coccidioidomycosis/treatment.html

*  Coccidioidomycosis | The New York Academy of Sciences

Coccidioidomycosis is an emerging fungal disease caused by Coccidioides immitis that causes an influenza-like illness in ... Coccidioidomycosis. Edited by Edited by Karl V. Clemons (Santa Clara Valley Medical Center, Santa Clara, California; Stanford ... The proceedings of the sixth conference on coccidioidomycosis presents state of the art overviews of our current understanding ...
https://nyas.org/annals/coccidioidomycosis/

*  Coccidioidomycosis outbreak among United States Navy SEALs training in a Coccidioides immitis-endemic area--Coalinga,...

Ten (45%) of the 22 men had serologic evidence of acute coccidioidomycosis, the highest attack rate ever reported for a ... An outbreak of coccidioidomycosis among 22 Navy SEALs occurred during training exercises in Coalinga, California. ... Coccidioidomycosis continues to be a threat to military members and civilians who reside or train in areas where Coccidioides ... An outbreak of coccidioidomycosis among 22 Navy SEALs occurred during training exercises in Coalinga, California. Ten (45%) of ...
biomedsearch.com/nih/Coccidioidomycosis-outbreak-among-United-States/12198626.html

*  Coccidioidomycosis Imaging: Overview, Radiography, CT Scan

... causes an illness in humans called coccidioidomycosis. Growth of C immitis occurs in 2 phases: (1) the mycelial arthrospore ... encoded search term (Coccidioidomycosis%20Imaging) and Coccidioidomycosis Imaging What to Read Next on Medscape. Related ... Johnson RH, Caldwell JW, Welch G. The great coccidioidomycosis epidemic: clinical features. Einstein HE, ed. Coccidioidomycosis ... causes an illness in humans called coccidioidomycosis. Coccidioidomycosis is found in Arizona, California, New Mexico, Texas, ...
https://emedicine.medscape.com/article/2137779-overview

*  DMOZ - Health: Conditions and Diseases: Infectious Diseases: Fungal: Coccidioidomycosis

"Health ... Coccidioidomycosis" search on: AOL - Ask - Bing - DuckDuckGo - Gigablast - Google - ixquick - Yahoo - Yandex - Yippy ... Merck Manual: Coccidioidomycosis Provides information on this disease caused by the fungus Coccidioides immitis, its ... The BBC reports on Avenal, a southern California city with an epidemic of coccidioidomycosis, which also affects dogs, llamas ... BioMed Central: Combination Therapy of Disseminated Coccidioidomycosis with Caspofungin and Fluconazole Research article which ...
dmoztools.net/Health/Conditions_and_Diseases/Infectious_Diseases/Fungal/Coccidioidomycosis/

*  Fungizone User Reviews for Coccidioidomycosis, Meningitis at Drugs.com

Reviews and ratings for fungizone when used in the treatment of coccidioidomycosis, meningitis. Share your experience with this ... Reviews for Fungizone to treat Coccidioidomycosis, Meningitis. No reviews have yet been submitted. Be the first to review this ...
https://drugs.com/comments/amphotericin-b/fungizone-for-coccidioidomycosis-meningitis.html

*  The Exanthem of Acute Pulmonary Coccidioidomycosis: Melbourne Dermatology Skin Care

The Exanthem of Acute Pulmonary Coccidioidomycosis section for articles, skin care ingredients, and notes on skin condition ... The Exanthem of Acute Pulmonary Coccidioidomycosis - A look inside the world of medically proven skin care from the people of ... The Exanthem of Acute Pulmonary Coccidioidomycosis. Tweet Clinical and Histopathologic Features of 3 Cases and Review of the ... Coccidioidomycosis may be associated with a reactive generalized cutaneous eruption early in the course of the illness. ...
treatment-skincare.com/May-2006/Coccidioidomycosis.html

*  What Is Microbiology - Coccidioidomycosis - Medicalrealm

Eosinophilia is a useful laboratory marker for coccidioidomycosis. ... Coccidioidomycosis is caused by Coccidioides immitis. Coccidioides immitis is detected as spherules via direct examination of ... What Is Microbiology - Coccidioidomycosis. Coccidioidomycosis. Coccidioidomycosis is caused by Coccidioides immitis. ... Acute infection of coccidioidomycosis may be identified by the responses of the Coccidioides immitis specific IgM. Coccidioides ...
medicalrealm.net/what-is-microbiology---coccidioidomycosis.html

*  ASMscience | Travel-Associated Fungal

The diagnosis of acute pulmonary coccidioidomycosis can be made by direct microscopic examination of lower respiratory tract ... such as blastomycosis and coccidioidomycosis, and prior infection or residence in an area of endemicity can result in the ... travel has led to a rise in the number of reported outbreaks and sporadic cases of histoplasmosis and coccidioidomycosis among ... Cases of coccidioidomycosis seen in Britain, p. 301-308. In L. Ajello (ed.), Proceedings of Second Coccidioidomycosis Symposium ...
asmscience.org/content/book/10.1128/9781555816995.chap10

*  Taking diflucan for 3mths for valley fever,had rash, now dizzy, how long do I need to take this?

... coccidioidomycosis - Answer: that would be for your doctor to answer because it would be a different ... ... Coccidioidomycosis - What side effects could be expected after three years of Diflucan, 600-1,000?. Posted 19 Sep 2009 • 1 ...
https://drugs.com/answers/i-have-been-taking-diflican-for-3-months-because-403609.html

*  Skin Lesion of Coccidioidomycosis

Skin lesions of coccidioidomycosis are a symptom of ... Skin Lesion of Coccidioidomycosis. Medically Reviewed by Modern ... What Are Skin Lesions of Coccidioidomycosis?. Coccidioidomycosis is an infection known more commonly as "valley fever." It's ... Coccidioidomycosis is most commonly contracted in desert regions in the southwestern United States, and in Central and South ... Antifungal medications are used to treat the skin lesions associated with coccidioidomycosis. ...
https://healthline.com/health/skin-lesion-of-coccidioidomycosis

*  Coccidioidomycosis | health.am

Acute coccidioidomycosis is rare. In any given year, about 3% of people who live in an area where coccidiomycosis is commonly ... Chronic pulmonary coccidioidomycosis can develop 20 or more years after initial infection which may not have been recognized, ... Acute pulmonary coccidioidomycosis is almost always mild, with few or no symptoms, and resolves without treatment. The ... Individuals with AIDS are at higher risk for pulmonary (lung) coccidioidomycosis, as well as for the disseminated (spread to ...
health.am/encyclopedia/more/coccidioidomycosis/

*  Coccidioidomycosis | Good Samaritan Hospital

Learn more about Coccidioidomycosis at Good Samaritan Hospital DefinitionCausesRisk ... Hospitalizations for coccidioidomycosis at forty-one children's hospitals in the United States. Pediatr Infect Dis J. 2010;29(3 ... The public health impact of coccidioidomycosis in Arizona and California. Int J Environ Res Public Health. 2011;8(4):1150-1173. ... Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosis. Clin Infect Dis. 2009;48(2): ...
https://goodsamsanjose.com/hl/?/200994/sp

*  DISSEMINATED COCCIDIOIDOMYCOSIS WITH CLINICAL PRESENTATION OF CHORIORETINOPATHY AND MENINGITIS | American Academy of Optometry

DISSEMINATED COCCIDIOIDOMYCOSIS WITH CLINICAL PRESENTATION OF CHORIORETINOPATHY AND MENINGITIS. Title DISSEMINATED ... attributed to coccidioidomycosis which presented as a disseminated form of meningitis and unilateral chorioretinopathy. ...
aaopt.org/disseminated-coccidioidomycosis-clinical-presentation-chorioretinopathy-and-meningitis

*  Secondary coccidioidomycosis | definition of secondary coccidioidomycosis by Medical dictionary

... secondary coccidioidomycosis explanation free. What is secondary coccidioidomycosis? Meaning of secondary coccidioidomycosis ... Looking for online definition of secondary coccidioidomycosis in the Medical Dictionary? ... secondary coccidioidomycosis. sec·on·dar·y coc·cid·i·oi·do·my·co·sis. progressive or disseminated extrapulmonary granulomatous ... Secondary coccidioidomycosis , definition of secondary coccidioidomycosis by Medical dictionary https://medical-dictionary. ...
medical-dictionary.thefreedictionary.com/secondary coccidioidomycosis

*  Coccidioidomycosis

... ". Clin Infect Dis. vol. 41. 2005. pp. 1217-23. (IDSA guidelines for the therapy of coccidioidomycosis.) ... How can coccidioidomycosis be prevented?. There is no effective vaccine for the prevention of coccidioidomycosis. Prevention is ... Coccidioidomycosis in pregnancy. Coccidioidomycosis is uncommon during pregnancy but is associated with a high rate of ... Congenital/neonatal coccidioidomycosis. Neonatal coccidioidomycosis has been reported, often in association with maternal ...
psychiatryadvisor.com/pediatrics/coccidioidomycosis/article/621829/

*  Coccidioidomycosis. - MyScienceWork

Coccidioidomycosis.. Authors * SMITH, C E Type. Published Article. Journal. Pediatric clinics of North America Publication Date ... Coccidioidomycosis From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on ...
https://mysciencework.com/publication/show/coccidioidomycosis-ab7695ab

Primary pulmonary coccidioidomycosis: Primary pulmonary coccidioidomycosis is an infection caused by inhalation of Coccidioides immitis. Once pulmonary symptoms subside, about 30% of women and 15% of men will have allergic skin manifestations in the form of erythema nodosum.Uncinocarpus: Uncinocarpus is a genus of fungi within the Onygenaceae family. Being a close non-pathogenic relative of the pathogenic dimorphic fungi Coccidioides immitis and Coccidioides posadasii, which causeArizona State Prison Complex – Perryville: Arizona State Prison Complex – Perryville is one of 13 prison facilities operated by the Arizona Department of Corrections (ADC)."Arizona State Prison Complex- Perryville.Arthur Wilson (Royal Navy officer)VoriconazoleBlastomycosisPrimary cutaneous aspergillosis: Primary cutaneous aspergillosis is a rare skin condition most often occurring at the site of intravenous cannulas in immunosuppressed patients.Southwestern United States: The Southwestern United States (also known as the American Southwest) is the United States portion of the Southwest (which is situated in both the United States and Mexico). It is a region of the United States defined in different ways by different sources.Presumed ocular histoplasmosis syndrome: Presumed ocular histoplasmosis syndrome (POHS) is a syndrome affecting the eye, which is characterized by peripheral atrophic chorioretinal scars, atrophy or scarring adjacent to the optic disc and maculopathy.Theodor Bilharz Research Institute: The Theodor Bilharz Research Institute is located in Giza, Egypt.Computational archaeology: Computational archaeology describes computer-based analytical methods for the study of long-term human behaviour and behavioural evolution. As with other sub-disciplines that have prefixed 'computational' to their name (e.Ameridose: Ameridose, LLC. is a large-scale compounding pharmacy based in Westborough, Massachusetts.Fluconazole

(1/380) Lung weight parallels disease severity in experimental coccidioidomycosis.

Evidence provided by histopathological study of lesions is a valuable adjunct for evaluating chemotherapeutic efficacy in experimental animal models, In addition, this should be correlated with a measure of disease severity in the same animal. The latter could be obtained by homogenization of infected organs and quantitative enumeration of viable cells of the etiological agent, but this would preclude histopathological studies in the same animal. Progression of disease in pulmonary infection is associated with replacement of air space by fluid, cells, and cellular debris. Therefore, an increase in lung weight should reflect severity of disease. Results with the murine model of coccidioidomycosis demonstrate that increasing lung weight parallels the increasing census of fungus cells in the lungs of both treated and nontreated infected mice. This was supported with evidence obtained from microscopic studies of lesions indicating that specific chemotherapy limited spread of the infection and inhibited multiplication of the fungus in the lung. Therefore, lung weight can be used as a measure of disease severity in the murine model of coccidioidomycosis.  (+info)

(2/380) MR imaging of acute coccidioidal meningitis.

BACKGROUND AND PURPOSE: Our purpose was to describe the MR imaging findings in patients with acute coccidioidal meningitis. METHODS: Fourteen patients (11 men, three women; 22-78 years old; mean age, 47 years) with coccidioidal meningitis underwent neuroimaging within 2 months of diagnosis. Thirteen patients had MR imaging and one had an initial CT study with a follow-up MR examination 5 months later. Initial and follow-up MR images were evaluated for the presence of ventricular dilatation, signal abnormalities, enhancement characteristics, sites of involvement, and evidence of white matter or cortical infarction. The patterns of enhancement were characterized as focal or diffuse. Pathologic specimens were reviewed in two patients. RESULTS: Ten of the 14 images obtained at the time of initial diagnosis showed evidence of meningitis. All of the initially abnormal studies showed enhancement in the basal cisterns, sylvian fissures, or pericallosal region. Subsequent studies, which were available for three of the four patients with normal findings initially, all eventually became abnormal, with focal enhancement seen on the initial abnormal examination. Other abnormalities seen at presentation included ventricular dilatation (six patients) and deep infarcts (four patients). Pathologic specimens in two patients showed focal collections of the organism corresponding to the areas of intense enhancement on MR images. CONCLUSION: Early in its disease course, coccidioidal meningitis may show areas of focal enhancement in the basal cisterns, which may progress to diffuse disease. Pathologically, the areas of enhancement represent focal collections of the organism. Deep infarcts and communicating hydrocephalus are associated findings.  (+info)

(3/380) Endemic mycoses: a treatment update.

Endemic mycoses remain a major public health problem in several countries and they are becoming increasingly frequent with the spread of HIV infection. Amphotericin B remains the drug of choice during the acute stage of life-threatening endemic mycoses occurring in both immunocompetent and immunocompromised hosts. Ketoconazole is effective in non-AIDS patients with non-life-threatening histoplasmosis, blastomycosis, or paracoccidioidomycosis. Itraconazole is the treatment of choice for non-life-threatening Histoplasma capsulatum or Blastomyces dermatitidis infections occurring in immunocompetent individuals and is the most efficient secondary prophylaxis of histoplasmosis in AIDS patients. Itraconazole is also effective in lymphocutaneous and visceral sporotrichosis, in paracoccidioidomycosis, for Penicillum marneffei infection, and is an alternative to amphotericin B for Histoplasma duboisii infection. Coccidioidomycosis may be effectively treated with prolonged and sometimes life-long itraconazole or fluconazole therapy. Fluconazole has relatively poor efficacy against histoplasmosis, blastomycosis and sporotrichosis. New antifungal agents have been tested in vitro or in animal models and may soon be evaluated in clinical trials.  (+info)

(4/380) Reactivation of coccidioidomycosis in a fit American visitor.

The case history is presented of an American visitor, known to have had primary coccidioidomycosis previously, who became very unwell during a visit to the UK. Despite consideration of reactivation of coccidioidomycosis from the outset, other pathogens were identified while Coccidioides immitis was not initially, leading to a delay in treatment.  (+info)

(5/380) The first imported case of pulmonary coccidioidomycosis in Korea.

Coccidioidomycosis is an endemic disease found in the southwestern part of North America. Travellers who visit the endemic area may carry the infection. We report a case of pulmonary coccidioidomycosis in a 74-year-old woman. She was healthy before visiting Arizona, U.S.A twice. After returning home, she began to complain of intermittent dry coughing. The symptom was mild, however, and she was treated symptomatically. Later a chest radiograph, which was taken 4 years after the onset of the symptom, showed a solitary pulmonary nodule in the right upper lobe. By percutaneous needle aspiration, a few clusters of atypical cells were noted in the necrotic background. A right upper and middle lobectomy was done. A 1.5 x 1.5 x 1.2 cm sized tan nodule was present in otherwise normal lung parenchyma. Microscopically, the nodule consisted of aggregates of multiple solid granulomas inside of which was mostly necrotic. Neutrophils and nuclear debris were scattered along the periphery of the necrotic foci. Numerous multinucleated giant cells were associated with the granulomas. In the necrotic area, mature spherules of Coccidioides immitis, which were 30-100 microm in diameter, were present. They contained numerous endospores which ranged from 5 to 15 microm and were also noted in multinucleated giant cells. The diagnosis of coccidioidomycosis was made. She is doing well after the resection.  (+info)

(6/380) Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice.

Coccidioidomycosis is a fungal infection that is endemic in the southwestern United States. Infection is more severe in blacks and Filipinos, which suggests that there is a genetic basis for susceptibility to this infection in humans. We found that there is also a difference in resistance to Coccidioides immitis infection among inbred mouse strains: B6 mice are susceptible, while DBA/2 mice are resistant (T. N. Kirkland and J. Fierer, Infect. Immun. 40:912-916, 1983). In this paper we report the results of our efforts to map the genes responsible for resistance to this infection in mice. Mice were infected by intraperitoneal inoculation, and 15 days later the numbers of viable fungi in their lungs and spleens were enumerated. We also determined the amounts of interleukin-10 mRNA made in the infected lungs. These three phenotypes were mapped as quantitative traits by using the 26 available lines of recombinant inbred mice derived from a cross between B6 and DBA/2 mice. The best associations were those between the regions near the Lv locus on chromosome 4 and the Tnfr1 locus on chromosome 6. We then infected backcross mice [(B6 x DBA/2) x B6] and confirmed these associations; 14 of 16 (87%) mice that were heterozygous at both Lv and Tnfr1 were resistant to infection, whereas only 4 of 16 (25%) mice that were homozygous B6 at both loci were resistant. These are the first genetic loci to be associated with susceptibility to C. immitis, but there may be additional genes involved in murine resistance to this infection.  (+info)

(7/380) Resistance to Coccidioides immitis in mice after immunization with recombinant protein or a DNA vaccine of a proline-rich antigen.

Two inbred strains of mice (BALB/c and C57BL/6) were vaccinated with either recombinant expression protein of a Coccidioides immitis spherule-derived proline-rich antigen (rPRA) in monophosphoryl lipid A-oil emulsion adjuvant or a DNA vaccine based on the same antigen. Four weeks after vaccination, mice were infected intraperitoneally with arthroconidia. By 2 weeks, groups of mice receiving saline or plasmids with no PRA insert exhibited significant weight loss, and quantitative CFUs in the lungs ranged from 5.9 to 6.4 log10. In contrast, groups of mice immunized with either rPRA or DNA vaccine had significantly smaller pulmonary fungal burdens, ranging from 3.0 to 4.5 log10 fewer CFUs. In vitro immunologic markers of lymphocyte proliferation and gamma interferon (IFN-gamma) release after splenocytes were stimulated with rPRA correlated with protection. Also, plasma concentrations of rPRA-specific total immunoglobulin G (IgG), IgG1, and IgG2a showed increases in vaccinated mice. These studies expand earlier work by demonstrating protection in mice which differ in H-2 background, by using an adjuvant that is potentially applicable to human use, and by achieving comparable protections with a DNA-based vaccine. Our in vitro results substantiate a Th1 response as evidenced by IFN-gamma release and increased IgG2a. However, IgG1 was also stimulated, suggesting some Th2 response as well. PRA is a promising vaccine candidate for prevention of coccidioidomycosis and warrants further investigation.  (+info)

(8/380) Construction of a single-chain interleukin-12-expressing retroviral vector and its application in cytokine gene therapy against experimental coccidioidomycosis.

T-cell-mediated immunity is an important determinant in protection against primary infection with Coccidioides immitis, a dimorphic fungal pathogen that causes the disease coccidioidomycosis. To determine if interleukin-12 (IL-12) gene therapy could potentiate host response against C. immitis, we constructed a single-chain cDNA encoding the p40 and p35 subunits linked by a polylinker and, using a retroviral vector, transfected J774 macrophages with the construct. The transduced J774 cells expressed IL-12 in vitro, with a mean concentration of 28,440 pg from 10(6) cells in 48 h as measured by an IL-12 (p75)-specific enzyme-linked immunosorbent assay. The secreted IL-12 was biologically active, as judged by its ability to induce the production of gamma interferon (IFN-gamma) by spleen cells from BALB/c mice. Treatment of the highly susceptible BALB/c mouse strain with the IL-12-transduced J774 cells inhibited C. immitis growth in tissues from mice challenged by a pulmonary route, as evidenced by 1.37-, 2.59-, and 1.22-log reductions in the number of CFU in the lungs, spleens, and livers, respectively, compared to the fungal load in mice given vector-transduced J774 cells. The protective effect of IL-12 gene therapy was accompanied by increased levels of IFN-gamma in the lungs and sera of mice treated with IL-12-transduced J774 cells and the constitutive production of IFN-gamma by their spleen cells cultured in vitro. These results suggest that IL-12 gene therapy could be used as adjunct therapy for coccidioidomycosis.  (+info)



pulmonary


  • Individuals with AIDS are at higher risk for pulmonary (lung) coccidioidomycosis, as well as for the disseminated (spread to many body systems) and cutaneous (skin) forms of the disease. (health.am)
  • Acute pulmonary coccidioidomycosis is almost always mild, with few or no symptoms, and resolves without treatment. (health.am)
  • Chronic pulmonary coccidioidomycosis can develop 20 or more years after initial infection which may not have been recognized, diagnosed, or treated at the time. (health.am)
  • On the basis of clinical presentation and imaging abnormalities, pulmonary involvement of coccidioidomycosis is categorized into acute, disseminated, and chronic forms. (medscape.com)
  • Chest radiography should be performed in all patients in whom coccidioidomycosis is suspected or confirmed, because of the possibility of pulmonary infection. (medscape.com)
  • Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosis. (goodsamsanjose.com)
  • We describe 3 patients with a florid eruption associated with pulmonary coccidioidomycosis . (treatment-skincare.com)
  • Coccidioidomycosis, a mild flulike illness in approximately 40% of infected persons, progresses to severe pulmonary or disseminated disease in 1% to 10% of symptomatic cases. (cdc.gov)

Fungal


  • PET scans are increasingly used in the diagnosis and staging of invasive fungal infections, including coccidioidomycosis, and may be able to detect lesions that are not otherwise visualized with CT. (medscape.com)
  • Valley fever, or coccidioidomycosis, is a fungal disease endemic to the southwest United States and parts of Mexico, South America and Central America. (kcanimalhospital.com)

Acute


  • Acute coccidioidomycosis is rare. (health.am)
  • Ten (45%) of the 22 men had serologic evidence of acute coccidioidomycosis, the highest attack rate ever reported for a military unit. (biomedsearch.com)
  • Other cutaneous manifestations of primary coccidioidomycosis include an acute generalized exanthem ("toxic erythema") that appears early after the onset of symptoms and is usually macular, papular, or morbilliform, and sometimes target-like. (psychiatryadvisor.com)
  • Acute infection of coccidioidomycosis may be identified by the responses of the Coccidioides immitis specific IgM. (medicalrealm.net)

infectious diseases


  • Chest radiographic findings alone are not diagnostic of thoracic coccidioidomycosis, because other infectious diseases and neoplastic processes may mimic the disorder. (medscape.com)

endemic


  • Coccidioidomycosis outbreak among United States Navy SEALs training in a Coccidioides immitis-endemic area--Coalinga, California. (biomedsearch.com)
  • Coccidioidomycosis continues to be a threat to military members and civilians who reside or train in areas where Coccidioides immitis, the causative agent, is endemic. (biomedsearch.com)
  • Coccidioidomycosis is an endemic mycosis of the Southwestern United States, Northern Mexico, and some areas of Central and South America. (psychiatryadvisor.com)

California


  • Infection with Coccidioides immitis , a soil-inhabiting fungus native to the San Joaquin Valley in California, causes an illness in humans called coccidioidomycosis . (medscape.com)
  • Coccidioidomycosis is found in Arizona, California, New Mexico, Texas, northern Mexico, and other areas with a climate similar to that of South America. (medscape.com)
  • An outbreak of coccidioidomycosis among 22 Navy SEALs occurred during training exercises in Coalinga, California. (biomedsearch.com)
  • Participants included African-American, Caucasian, and Hispanic persons with mild or severe disseminated coccidioidomycosis from Kern County, California. (cdc.gov)
  • The BBC reports on Avenal, a southern California city with an epidemic of coccidioidomycosis, which also affects dogs, llamas and alpacas. (dmoztools.net)

Exanthem


  • The presence of the exanthem , in combination with fever and/or pneumonia, was a helpful clue to the diagnosis of coccidioidomycosis. (treatment-skincare.com)

fluconazole


  • The common treatment of coccidioidomycosis may include itraconazole, fluconazole and amphotericin B. (medicalrealm.net)

Meningitis


  • A 65 year-old Caucasian male with new onset blurred vision and cognitive/gait deficit, underwent ventriculoperitoneal shunt placement for hydrocephalus, attributed to coccidioidomycosis which presented as a disseminated form of meningitis and unilateral chorioretinopathy. (aaopt.org)
  • Coccidioidomycosis may disseminated and lead to extrapulmonary condition such as meningitis or involvement of the skin and bone. (medicalrealm.net)

commonly


  • Coccidioidomycosis is an infection known more commonly as "valley fever. (healthline.com)
  • Coccidioidomycosis is most commonly contracted in desert regions in the southwestern United States, and in Central and South America. (healthline.com)
  • Coccidioidomycosis, commonly called valley fever, is a potentially-serious lung infection. (goodsamsanjose.com)

lesions


  • What Are Skin Lesions of Coccidioidomycosis? (healthline.com)
  • progressive or disseminated extrapulmonary granulomatous lesions following primary coccidioidomycosis. (thefreedictionary.com)

cutaneous


  • Coccidioidomycosis may be associated with a reactive generalized cutaneous eruption early in the course of the illness. (treatment-skincare.com)
  • Primary cutaneous coccidioidomycosis manifests as an ulcerated nodule at the site of inoculation, sometimes accompanied by regional lymphadenopathy. (psychiatryadvisor.com)

granulomatous


  • Sweet syndrome and reactive interstitial granulomatous dermatitis are rare manifestations of primary coccidioidomycosis. (psychiatryadvisor.com)

Chronic


  • See A Chronic, Scaly Rash Mistaken for MRSA: Case Presentation , a Critical Images slideshow, to review additional images and details of a case of Coccidioidomycosis. (medscape.com)

Coccidioides


include


  • Imaging studies in patients with suspected or confirmed coccidioidomycosis include plain chest radiography, computed tomography (CT), magnetic resonance imaging (MRI), and, possibly, positron-emission tomography (PET). (medscape.com)
  • The risk factors of coccidioidomycosis may include third trimester pregnant women and immunocompromised patient as well as Asians and blacks. (medicalrealm.net)

symptoms


  • Call for an appointment with your health care provider if symptoms develop that are suggestive of coccidioidomycosis. (health.am)

person to per


  • Coccidioidomycosis is not known transmit from person to person. (medscape.com)
  • There is no person-to-person transmission of coccidioidomycosis. (psychiatryadvisor.com)

skin


  • See also skin lesion of coccidioidomycosis. (health.am)

host


  • Influence of host genetics on the severity of coccidioidomycosis. (cdc.gov)

patient