Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.Stroop Test: Timed test in which the subject must read a list of words or identify colors presented with varying instructions and different degrees of distraction. (Campbell's Psychiatric Dictionary. 8th ed.)Vascular Headaches: Secondary headache disorders attributed to a variety of cranial or cervical vascular disorders, such as BRAIN ISCHEMIA; INTRACRANIAL HEMORRHAGES; and CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS.Central Nervous System Sensitization: An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS).Crack Cocaine: The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. Use of crack results in alterations in function of the cardiovascular system, the autonomic nervous system, the central nervous system, and the gastrointestinal system. The slang term "crack" was derived from the crackling sound made upon igniting of this form of cocaine for smoking.Dopamine Uptake Inhibitors: Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.Self Administration: Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.Cues: Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.Anxiety Disorders: Persistent and disabling ANXIETY.Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.Diagnostic and Statistical Manual of Mental Disorders: Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)Depressive Disorder, Major: Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.Stress Disorders, Post-Traumatic: A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
PsyGeNET - a database of gene-disease associationsPsyGeNET (Psychiatric disorders Gene association NETwork) is a resource for the exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of a database and a set of analysis tools, powered by Onexus (www.onexus.org). The database has been developed by automatic extraction of information from the literature using the text mining tool BeFree (http://ibi.imim.es/befree/), followed by curation by experts in the domain. A team of 22 experts participates as curators of the database (more information on our curation team here). This second release of PsyGeNET contains updated information on depression, bipolar disorder, alcohol use disorders and cocaine use disorders, and has been expanded to cover other psychiatric diseases of interest: bipolar disorder, schizophrenia, substance-induced depressive disorder and psychoses and cannabis use disorder. The current version of PsyGeNET (version 2.0) contains 3,771 ...
Acute cocaine hydrochloride poisoning | Article about acute cocaine hydrochloride poisoning by The Free DictionaryLooking for acute cocaine hydrochloride poisoning? Find out information about acute cocaine hydrochloride poisoning. a morbid condition caused by the action of poison on the body and accompanied by disruption of bodily systems and functions. In humans. Poisoning in humans... Explanation of acute cocaine hydrochloride poisoning
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Role of the NMDA Receptor and Nitric Oxide in Memory Reconsolidation of Cocaine-Induced Conditioned Place Preference in Mice -...Itzhak, Y. (2008), Role of the NMDA Receptor and Nitric Oxide in Memory Reconsolidation of Cocaine-Induced Conditioned Place Preference in Mice. Annals of the New York Academy of Sciences, 1139: 350-357. doi: 10.1196/annals.1432.051 ...
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Wheel-running attenuates intravenous cocaine self-administration in rats: sex differences.Abstract This experiment examines the effect of access to a running-wheel on intravenous cocaine self-administration in male and female rats. Rats maintained at 85\% of their free-..
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Influence of progesterone on GAD65 and GAD67 mRNA expression in the dorsolateral striatum and prefrontal cortex of female rats...Female rats are intensely affected by cocaine, with estrogen probably playing an important role in this effect. Progesterone modulates the GABA system and attenuates the effects of cocaine; however, there is no information about its relevance in changing GABA synthesis pathways after cocaine administration to female rats. Our objective was to investigate the influence of progesterone on the effects of repeated cocaine administration on the isoenzymes of glutamic acid decarboxylase (GAD65 and GAD67) mRNA in brain areas involved in the addiction circuitry. Ovariectomized, intact and progesterone replacement-treated female rats received saline or cocaine (30 mg/kg, ip) acutely or repeatedly. GAD isoenzyme mRNA levels were determined in the dorsolateral striatum (dSTR) and prefrontal cortex (PFC) by RT-PCR, showing that repeated, but not acute, cocaine decreased GADs/β-actin mRNA ratio in the dSTR irrespective ...
Plus itCebranopadol is a novel agonist of nociceptin/orphanin FQ peptide (NOP) and opioid receptors with analgesic properties that is being evaluated in clinical Phase 2 and Phase 3 trials for the treatment of chronic and acute pain. Recent evidence indicates that the combination of opioid and NOP receptor agonism may be a new treatment strategy for cocaine addiction. We sought to extend these findings by examining the effects of cebranopadol on cocaine self-administration (0.5 mg/kg/infusion) and cocaine conditioned reinstatement in rats with extended access to cocaine. Oral administration of cebranopadol (0, 25, and 50 μg/kg) reversed the escalation of cocaine self-administration in rats that were given extended (6 hour) access to cocaine, whereas it did not affect the self-administration of sweetened condensed milk (SCM). Cebranopadol induced conditioned place preference but did not affect locomotor activity ...
Data Available on the Extent of Cocaine Use and Dependence: Bioch...: Ingenta ConnectDrug use is seen more as an individualistic behaviour and is therefore not readily conceived of from a population perspective. There is general recognition of several phases and degrees of drug abuse, from initiation and early-use patterns to long-term chronic use. Cocaine and its derivative "crack" cocaine provide an example of both the globalization of substance use and the cyclical nature of drug epidemics. Cocaine is a powerful CNS (Central Nervous System) stimulant but exerts its action in a several types of adverse health effects, including acute toxic effects (i.e. overdose, accidental injury and violence), dependence, cardiovascular disease, cirrhosis, bloodborne bacterial and viral infections, and mental disorders. Of interest, many people who use Cocaine will use also other drugs; therefore, ascribing adverse health effect to a certain drug might be difficult. Any mucous membrane can act as a port of entry for ...
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Private Cocaine Addiction Treatment | Executive Cocaine RehabMany executives and business professionals benefit from private residential cocaine rehab treatment that is discreet and confidential. Cocaine (coke) is becoming more socially acceptable among young city professionals and executives who work in finance, law and the media. Some business professionals use cocaine during the day to give them energy and maintain the
Vaccine Produces Immunity Against Cocaine High - RedorbitThe vaccine is poised to move quickly into human trials. Researchers from The Scripps Research Institute, Weill Cornell Medical College, and Cornell University have produced a long-lasting anti-cocaine immunity in mice by giving them a unique vaccine that combines bits of the common cold virus with a particle that mimics cocaine.. In their study, published January 4, 2011, in the advanced online edition of Molecular Therapy, the researchers say this novel strategy might be the first to offer cocaine addicts a fairly simple way to break and reverse their habit. The approach could also be useful in treating other addictions, such as to nicotine, heroin, and methamphetamine.. "Our very dramatic data shows that we can protect mice against the effects of cocaine, and we think this approach could be very promising in fighting addiction in humans," says the study's lead investigator, Ronald G. Crystal, chairman and professor of genetic medicine at ...
Overexposure to Cocaine may Lead to Structural Changes in BrainA new study conducted by American researchers has found that chronic use of cocaine may lower the levels of a protein that has been found to regulate brain plasticity.
"Immunopathogenesis of HIV Infection in Cocaine Users: Role of Arachido" by Thangavel Samikkannu, Kesava Rao Venkata Kurapati...Arachidonic acid (AA) is known to be increased in HIV infected patients and illicit drug users are linked with severity of viral replication, disease progression, and impaired immune functions. Studies have shown that cocaine accelerates HIV infection and disease progression mediated by immune cells. Dendritic cells (DC) are the first line of antigen presentation and defense against immune dysfunction. However, the role of cocaine use in HIV associated acceleration of AA secretion and its metabolites on immature dendritic cells (IDC) has not been elucidated yet. The aim of this study is to elucidate the mechanism of AA metabolites cyclooxygenase-2 (COX-2), prostaglandin E2 synthetase (PGE2), thromboxane A2 receptor (TBXA2R), cyclopentenone prostaglandins (CyPG), such as 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2), 14-3-3 ζ/δ and 5-lipoxygenase (5-LOX) mediated induction of IDC immune dysfunctions in cocaine using HIV positive patients. The plasma levels of AA, PGE2, ...
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. -...J Pharmacol Exp Ther. 2009 Nov;331(2):445-55. doi: 10.1124/jpet.108.150029. Epub 2009 Aug 26. Research Support, N.I.H., Extramural
Chromatin | Gene DatabaseSupplementary Table 1. Nucleosome occupancy events after repeated cocaine exposure. Nucleosome occupancy events were computed from total H3 ChIP-seq data using DANPOS as described in Methods. The chromosomal locations of these events are shown in the Table as Start to Finish, and were then annotated to the genome accordingly.. Supplementary Table 2. Nucleosome shift events after repeated cocaine exposure. Nucleosome shift events were computed from total H3 ChIP-seq data using DANPOS as described in Methods. The chromosomal locations of these events are shown in the Table as Start to Finish, and were then annotated to the genome accordingly.. ...
Cocaine causes atrial Purkinje fiber damage.Comparisons of atrial tissues from Syrian hamster offspring born from cocaine-treated mothers during the last days of pregnancy with sham-treated ones demonstrate irreversible focal ischemic damage in the Purkinje myofibers and minor endocardial dama
Holland man indicted for selling fentanyl, heroin and cocaine | USAO-NDOH | Department of JusticeA nine-count indictment was filed charging a Holland man with trafficking heroin, fentanyl and cocaine, said U.S. Attorney Justin E. Herdman and FBI Special Agent in Charge Stephen D. Anthony.. Terrance Lewis, 27, distributed more than 290 grams of fentanyl, 87 grams of heroin and three grams of cocaine between November 2015 and April 2017, according to the indictment.. If convicted, the defendant's sentence will be determined by the court after reviewing factors unique to this case, including the defendant's prior criminal record, if any, the defendant's role in the offense and the characteristics of the violation. In all cases the sentence will not exceed the statutory maximum and in most cases it will be less than the maximum.. The investigating agency in this case is the Federal Bureau of Investigation in Toledo. The case is being handled by Assistant U.S. Attorney Michael J. Freeman.. An indictment is only a charge and is not evidence of guilt. Defendants are entitled ...
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Common genes could explain alcohol, nicotine, cocaine addictions - Thaindian NewsResearchers may be honing in on specific genes tied to all types of addictions and finding that some of the same genes associated with alcohol dependence are also closely linked with addictions to nicotine, cocaine, opoids, heroin and other
Comparison of the frequency and enjoyability of pleasant events in cocaine abusers vs. non-abusers using a standardized...Abstract AIMS: To examine whether cocaine abusers differ from non-abusers in their frequency and enjoyability of engaging in various
The War on PolygamyReferences: Liu, Y., Young, K. A., Curtis, J. T., Aragona, B. J., & Wang, Z. (2011). Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism. Journal of Neuroscience,31(22), 7960-7966. doi:10.1523/jneurosci.1006-11.2011. 2Hecht GS, Spear NE, Spear LP (1999) Changes in progressive ratio responding for intravenous cocaine throughout the reproductive hhhhhhprocess in female rats. Dev Psychobiol 35:136 -145.. 1Schenk S, Lacelle G, Gorman K, Amit Z (1987) Cocaine self-administration in rats influenced by environmental conditions: implications for the etiology of drug abuse. Neurosci Lett 81:227-231.. ...
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Gov. Brown vetoes bill allowing misdemeanors for cocaine, heroin - latimesSACRAMENTO -- Gov. Jerry Brown on Saturday vetoed legislation that would have allowed prosecutors to charge possession of heroin, cocaine and other hard drugs as a misdemeanor rather than a felony.
Fight Cocaine From The Demand Side - tribunedigital-chicagotribuneOne of the nation's best research labs has confirmed what decades of frustration should have taught America about its cocaine habit: Treating users is more effective than busting pushers.Seven times
Cocaine plot mastermind jailed for 18 years | Daily Mail OnlineA former public schoolboy was jailed yesterday for shipping £3million of cocaine from South America to his mother's home in Surrey
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Accused cocaine dealer charged with participating in corrupt organization - tribunedigital-mcallA man charged earlier this year with supplying cocaine to a Whitehall Township man for years was charged Thursday with participating in a corrupt organization.Christian A. Martinez, 36, of Allentown
Mission Impossible Video - Cocaine - CBS.comWilliam Shatner guest stars as Joe Conrad, a drug dealer who becomes the unwitting dupe of the Impossible Missions Force in their plan to capture the largest shipment of cocaine ever brought into the country. (TV- PG)
Behavioral and epigenetic mechanisms in extinction of cocaine-induced memories - Kennon LattalCocaine abuse is a significant public health problem, with approximately 1.4 million Americans meeting the DSMIV criteria for cocaine dependence and acute overd...
Legal but lethal: So-called 'legal highs' are every bit as deadly as heroin and cocaine | Daily Mail OnlineKnown as 'legal highs', these drugs are supposedly safe - the chemical equivalent of a boozy lunch, but without a hangover or any lasting ill-effects.
Liquid Cocaine #6 (The Webtender)Mix the alcohol in an 8-12oz glass. Cover and shake for about 3 seconds. Mix the juices together in a glass of your choice, (add ice for character), and pour in alcohol. Serve chilled.. ...
Cocaine and Ear NecrosisAny medical information provided by this site is not a replacement for medical diagnosis, treatment, or professional medical advice. It should not be used to treat or diagnose any medical condition. Always seek professional medical consultation by a licensed physician for diagnosis and treatment of any and all medical conditions - please, do not ignore your doctor's medical advice based on information written by the author or commenters of this site. Please do not ask me for medical advice, but instead contact a healthcare provider in your area. Anything written about office/hospital situations/events are fictional examples to get a point across. No patient is/will ever be a specific patient (unless given written permission), but a fictional one. To know more about how I handle medical information about patients please link here. Unless, I am praising a colleague, even those will be fictional. Any similarities to you or people you know is purely coincidental. My husband and I, and our dogs are ...
Abnormaldiversity: Giving a Child AwayRecently, a guy my Dad knows kicked his teenage daughter out of their home. She's been going out with a drug dealer, driving drunk and getting into lots of trouble. At one point, they found cocaine in their house, that she was storing for her boyfriend. Part of their concerns was legal, since they could be charged with possession if drugs are found in their house. Part of it was how viciously this girl had been treating her mother, and how much difficulty she'd been having with coping. And partly, it's that she has a younger brother, whom she has been verbally abusing and who has been getting more and more depressed lately. He's expressed fear for his safety, and they're hoping he can get better now that she's out of their home ...
Navigating the Life of Your Dreams: Stroop Test and DreamsI recently found an article that included the influence of the stroop test on individuals who have lucid dreams. It was interesting to see that people who have lucid dreams are better at the stroop test than people who have lucid dreams less than once a month or never. Consistent with some of the comments above and the results of the experiment, researchers believe that because people who have frequent lucid dreams are able to divide their attention they are also better at stroop tests (a combination of two levels of cognition). In sum, the stroop test can help researchers and participants understand that dreams are meaningful because lucid dreaming involves taking the time to interpret what is dream imagery and what is waking day experiences. I agree that by showing that we can connect ideas and words, dream recall would be easier for individuals who have frequent lucid dreams. This is because they are better are deciphering between their dream and their waking day experiences (and remembering ...
Stroop Effect-Can you pass this color test?Here is the test to understand the Stroop Effect. Here some color names are given. However your task is to read aloud the name of the color of the word. Try to read it as fast as possible.
Stroop Test, Inhibition and Brain-based coaching | SharpBrainsStephanie at Idealawg alerts us of a recent article, titled 'A Brain-based Approach to Coaching', that serves as follow-up to the one we wrote about on the
The Addiction Labyrinth: Problems after substance abuse (entire article)The Stroop test measures response inhibition, and it is based on the interference effect driven by the demand of naming the color of a word that is printed in a color incongruent with the name (eg, the word blue printed in red).20 The test consists of 3 conditions. The first condition (W) presents the words red, blue, and green printed in black ink, and patients are requested to read aloud these words. The second condition (C) presents strings of XXX printed in the same 3 colors, and patients have to name the colors as quickly and accurately as possible. The third condition (WC) introduces the interference effect: the words red, blue, and green are printed in incongruent colors and patients have to name the color and ignore the word. The interference score (IS) is calculated by subtracting a weighted mean of the first 2 conditions from the third condition [IS = WC 2 (C 3 W)/(C + W)]; then results are compared with normative values to evaluate the degree of impairment ...
Severe Peripheral Arterial Constriction, Acute Ischemia of Lower Extremity With Use of Methysergide and Ergotamine | JAMA...THE DEVELOPMENT of methysergide (Sansert) for the management of individuals with frequently recurring vascular headache has been a welcome adjunct to their care
Chronic pain and central sensitization - Brainless BloggerWhat is central sensitization? 'Pain itself often modifies the way the central nervous system works, so that a patient actually becomes more sensitive and gets more pain with less provocation. That sensitization is called
Illinois Crack Cocaine Addiction Treatment Centers and Rehab ProgramsIllinois Crack Cocaine rehab centers offer something for everyone. From luxury private residential options to stay-at-home programs. People ask themselves which is better for themselves or someone close to them. The answer really depends on the addicted person. While outpatient Crack Cocaine programs allow the addict to quit using at home and unsupervised, this is not always a good option. Many of the issues that contributed to the abuse of alcohol and drugs will stay close to home as well. This is why drug and alcohol studies illustrate the a lowered rate of relapsing for sixty and ninety day inpatient substance abuse treatment. Fortunately, many private clinics present a relaxed, calm atmosphere for their clients, as well as ReVia, Vivitrol or other medically-assisted programs when appropriate.. If you or a loved one wants to get help for a Crack Cocaine addiction in Illinois, our phone lines are staffed around the clock with expert advisors, waiting to be ...
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Crack / Cocaine | Southern Ontario Cocaine AnonymousIf crack cocaine made us feel miserable, why did so many of us continue to use? Ask a hundred cocaine addicts that same question and you will probably get a hundred different answers, but no matter how many reasons exist, one fact is certain: crack cocaine is a highly addictive drug. Once used, it becomes the root of most of our problems. ...
State police find crack cocaine after Bear Creek traffic stop - News - Citizens' VoiceState police seized dozens of crack cocaine packets from an alleged Philadelphia drug dealer during a traffic stop Monday on state Route 115 in Bear Creek Township, according to charges filed.. Investigators say Cayre Omar Jones had the drugs hidden in a fake WD-40 can that was on the floor behind the passenger seat. He had plans to sell the crack to a drug dealer at a fast food restaurant in Wilkes-Barre, they say.. The 21-year-old gave Trooper Mark Conrad permission to search his Cadillac sport utility vehicle and a narcotics dog led police to the drugs, arrest papers say.. Jones, of Erie Avenue in Philadelphia, was charged with possession of crack, possession with the intent to deliver crack, and possession of drug paraphernalia.. Police took Jones to be arraigned by on-duty Magisterial District Judge Donald Whittaker, who ordered Jones jailed in the Luzerne County Correctional Facility for lack of $150,000 cash bail.. In addition to the criminal charges, Jones was also cited for speeding ...
East St. Louis crack cocaine dealer sentenced in Southern District of Illinois | Belleville News-DemocratA 28-year-old man from East St. Louis was sentenced to more than three years in federal prison for dealing crack cocaine in the metro-east, the U.S. Attorney's Office said Thursday. Andrew Autoomp was charged in the Southern District of Illinois with one count of conspiring to distribute and possess with intent to distribute cocaine base and two counts of distribution of cocaine base.
Fears over crack cocaine threat | Daily Mail OnlineLevels of violence linked to the trafficking of crack cocaine in this country are 'very disturbing', Home Office minister Bob Ainsworth told a conference in Birmingham today
Man convicted of selling crack cocaine sentenced to 10 years - schurz-herald-mailA Washington County Circuit Court jury Tuesday convicted a Hagerstown man of selling crack cocaine a short distance from the Hagerstown courthouse where the trial was held.Gregory Harris, 45, was
The Push To Legalize Medical Crack CocaineNoted physician and author Rafael "Teabag" Littlefoot even testified before members of Congress that he had seen the benefits of the drug first-hand on a number of occasions. "Many of my patients experience increased levels of energy and excitement when on a strict crack regimen. I have seen bursts of energy that seem humanly impossible. One of my patients got so excited she ran right through my glass door and lifted up a Chevy Tahoe with her bare hands, she was 97 years young! Crack also has tremendous value as an appetite suppressant, I have patients that have lost hundreds of pounds on crack. They are having so much fun that they forget to eat. Crack is a miracle drug!" Dr. Littlefoot actually brought three of his patients to Washington, D.C. to testify with him, but they said that the Congressional hearing room was too cold and disappeared before they could be called to testify. ...
New rules slashing crack cocaine sentences go into effect - CNNMany inmates are being released starting Tuesday, thanks to changes easing the disparity between crack and powder cocaine sentences.
Home | Andy Baldwin's Journey with RecoveryDuring the late 1800's to the early 1900's, cocaine was a drug that was widely available and used by many. It was considered a miracle drug and used to treat and cure many ailments and diseases. It could be found in drug stores being sold alone or in combinations with other drugs. One well known item that contained cocaine as a main ingredient is the first formula for Coca Cola. This is a fact that remained true from 1886 to 1903. The Harrison Act of 1914 put restrictions on how the drug could be used. Physicians were no longer allowed to prescribe cocaine or any drug containing cocaine. It was the Narcotic Drugs Import and Export Act of 1922 that officially made the use of cocaine illegal.. There was a surge of increased use of the drug in the 1970's. Cocaine was often used in it's powder form despite it being illegal. The cheaper version of cocaine that is smoked is called crack ...
Health | www.millercountyliberal.com | Miller County LiberalHeavy consumption of diet soda can damage teeth as badly as methamphetamine or crack cocaine, a new study contends.. "You look at it side-to-side with 'meth mouth' or 'coke mouth,' it is startling to see the intensity and extent of damage more or less the same," said Dr. Mohamed Bassiouny, a professor of restorative dentistry at the Temple University School of Dentistry in Philadelphia.. Methamphetamine, crack cocaine and soda -- sweetened or not -- are all highly acidic and can cause similar dental problems, Bassiouny said in a study published recently in the journal General Dentistry.. The acid in soda is in the form of citric acid and phosphoric acid, Bassiouny said. Without good dental hygiene, constant exposure can cause erosion and significant oral damage, he said.. In his study, he found that a woman in her 30s who drank 2 liters of diet soda daily for three to five years experienced tooth rot and decay remarkably similar to that suffered by a 29-yearold ...
Police: 22 pit bulls, fentanyl, heroin & crack cocaine seized from residence of Birmingham City Schools employeeWe tell local Birmingham news & weather stories, and we do what we do to make Birmingham, Tuscaloosa, Gadsden & the rest of Central Alabama a better place to live.
Eight jailed for conspiring to supply heroin and crack cocaine across West Yorkshire - Yorkshire Evening PostEight people who conspired to supply Class A drugs across West Yorkshire have been jailed today after police investigated a so-called 'ring and bring' network.
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tosha ann brownm crack cocaine | The ExaminerWhile we harbor no disrespect for the Wall Street Journal who called us "that scrappy little paper from Southeast Texas," we prefer to think of ourselves as simple seekers of the truth. We're of the opinion that headlines and sound bites never tell the whole story. Our readers demand all the facts, facets and flavors of every story or event. And, they expect to be informed, educated and stirred to action.. ...
Traffic stop yields 61 bags of crack cocaine, other drugsA traffic stop in North Carolina has resulted in the seizure of large amounts of drugs, money and firearms, as well as three arrests
EFFECTS OF ELEMENT TYPES FOR CRACK TIPS IN WOVEN DCB MADE OF GLASS FIBRE-EPOXY RESINNowadays, textile and woven fabric composites are taken into consideration forapplications in high mechanical properties and every in-plane direction. However, developments inmodelling and characterisation of the fabric reinforced composite materials are considered more inthe effects of element types used in the mesh generation of the crack tip. The type of elementselected for the crack tip, a critical point for evaluation of crack growth in a double cantileverbeam (DCB) sample, is extremely important. In this study, results of strain energy release rate(SERR) meshed with singular and or brick elements with the experimental data were compared toselect better element type. The plotted results of the crack tips meshed with the brick elements andthe diagrams revealing the SERR in contrast to the crack length was evaluated. In addition, theaforementioned operation has been repeated for singular elements. The theory of the failuremechanics has been used to calculate the amounts of SERR for several crack
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Ex-Scarsdale dean's drug, prostitution case postponed again | NewsdayThe White Plains City Court case against a former Scarsdale High School dean accused of patronizing a prostitute and having crack cocaine was adjourned again
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How Close plans to crack the multi-family office market - CitywireClose Brothers Asset Management is aiming to grow its presence in the multi-family office market under new head of private clients Penny Lovell.. With around 40% of the £2.2 billion that Close manages in bespoke mandates in the £5 million-plus bracket, Lovell says this - alongside the firm's extensive platform - means it has laid solid foundations to offer clients a multi-family office-style service.. Under the stewardship of William Ladenburg, the firm plans to engage more actively with its family clients and external family offices to meet their differing and evolving needs. This could involve running mandates for family offices, or simply providing them with technology and support, Lovell said.. 'You may be a family who has made £20 million from the sale of a business and you want someone to look after it, or a family that wants a family office but doesn't want the staff and the aggro,' she said. 'We can white-label through Close Brothers Asset Management and this is something we will look ...
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Latest Placement Papers: Atrenta Placement Paperatrenta gives very high weightage internally to this 3rd section - they are looking for minds with reasoning and analytical approach to problem solving - so if u crack the 3rd section completely (which is quite easy to do from a normal guys point of view with 75%), and score well in the respective category (as in either coe or ece), u have a high chance of getting ...
Neurochemical mechanisms of ethanol self-administration - Rueben GonzalesThe mechanisms that underlie the development and maintenance of ethanol self-administration are not fully understood, but the involvement of dopamine in the mes...
What Can Pavlov's Dogs Tell Us About Drinking? - Neuroscience NewsSummary: Specific visual cues, such as seeing a liquor store, may prompt those with alcohol addiction to drink, a new study reports.. Source: Concordia University.. Researchers from Concordia University explain how fancy glassware and the sight of a liquor store can facilitate alcohol addiction.. Humans aren't much different from other animals. Just like Pavlov's dogs, we can become conditioned to associate environmental cues with rewards. Innocent enough when the sight of your sneakers makes you want to go for a run, but not necessarily so when the sight of the liquor store prompts you to want a drink.. Indeed, Pavlovian cues that predict alcohol can lead us toward addiction. And sometimes those cues can become desirable in and of themselves, as shown in a new study published in Frontiers in Behavioral Neuroscience by researchers from Concordia University in Montreal.. "Alcohol addiction is compounded by our ability to learn about predictive cues," says Nadia Chaudhri, the study's lead author ...
A Controlled Laboratory Study of the Effects on Cue-Induced Craving in Dependent Smokers - Tabular View - ClinicalTrials.govCigarette craving was assessed orally during each rTMS Session, before and after each stimulus presentation and cigarette smoking with a brief version of the Shiffman-Jarvik questionnaire (14), which contained items assessing cigarette craving using the following subscale: CRAVING ('urges to smoke,' 'miss a cigarette,' and 'crave cigarettes'), MOOD ('calm,' 'tense,' and 'irritable'), AROUSAL ('wide awake,' 'able to concentrate'), and HUNGER ('feel hungry'). The scale for the Shiffman-Jarvik questionnaire is a Likert item scale with measurements 1-Not at All; 2-Very Little; 3-A Little; 4-Moderately; 5- A Lot; 6-Quite A Lot and 7-Extremely. The change in craving for cigarettes after smoking cues versus neutral cues using the parenthetical items listed above with the subscale CRAVING were used to determine the primary outcome. A negative value represents a decrease in reported cigarette craving ...
Gold futures climb Rs 85 on global cues | Business Standard NewsRead more about Gold futures climb Rs 85 on global cues on Business Standard. Gold prices were trading up by Rs 85 to Rs 28,681 per 10 grams in futures trade today as speculators created positions amid positive cues from the global market.
Re: Cue the sax: Rick O'Dell launches SmoothJazzChicago.netPosted by WNUA WLFM on November 12, 2012 at 17:26:53:. In Reply to: Cue the sax: Rick O'Dell launches SmoothJazzChicago.net posted by the joy of sax on November 12, 2012 at 11:42:39:. : Cue the sax: Rick O'Dell launches SmoothJazzChicago.net. I wish him the best, its not an easy road and its a long road ...
Comments<...We all know the expression monkey see, monkey do. But should the saying really go monkey hear, monkey do? Recent studies are finding that the language abilities of some monkeys are more sophisticated than previously believed. Much more sophisticated.. Monkeys live together in social groups. All members contribute by helping to defend food sources, raise young, and watch for predators. But it is impossible to live in a social group without some form of communication. Group members need ways to influence and inform each other. This is what drives language. Monkeys have evolved many ways of communicating, including visual cues, auditory calls, and even some olfactory signals. Some of their visual signals are quite beautiful, like the long, curled tongue of the emperor tamarin, signaling to her mate when she wants to offload her babies. But visual signals only work if they can be seen. In the dense forest and underbrush that most primates live in, auditory cues are a much more powerful tool. Calls ...
CUE & A REVISITED: What Was Your First Stage Kiss?; 70 Actors Respond | PlaybillThe editors of Playbill.com have combed through the past seven years of our popular Cue & A feature to select some of our favorite answers to the question, 'What was your first stage kiss?' Seventy responses from Broadway actors follow.
Cue's Pulitzer ReviewsWhat are you living for if you don't have goals? Some goals define our lives, such as having children or pursuing a particular career.
Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses | International Journal...This initial evaluation of the demographic and clinical characteristics of patients with bipolar disorder enrolled in the Mayo Clinic Bipolar Disorder Biobank suggests a group with substantial psychiatric and medical comorbidity. The demographics and comorbid conditions of the study sample are representative of the general population of patients with bipolar disorder and, thus, potential research findings based on this sample would be generalizable. For example, the mean age and depressive-predominant disease are very similar to those reported in regulatory treatment trials for bipolar depression (McElroy et al. 2010). The percentages of comorbid anxiety, addiction, and obesity resemble other published demographics in longitudinal studies from the Stanley Foundation Bipolar Network (Leverich et al. 2001; Suppes et al. 2001) and the Systematic Treatment Enhancement Program for Bipolar Disorder (Kogan et al. 2004). The prevalence rates of high medical burden resemble other studies in bipolar ...
Bipolar Disorder Treatment Dubai | Best Service for Bipolar Disorder in DubaiBipolar disorder, or manic-depressive illness (MDI), is a severe and usually persistent mental disorder. It is a serious and often a lifelong struggle and challenge. Bipolar Disorder is characterized by episodes of mania or hypomania and episodes of more or less severe depression.
Bipolar Disorder | Mental Health AmericaBipolar Disorder: What You Need to Know Bipolar Disorder and African Americans Bipolar Disorder in Children Infographic: Life with Bipolar Mood Disorders 'What is Bipolar Disorder?' A Guide to Hope and Recovery for African Americans Staying Well When You Have a Mental Illness PDF
CBT Improves Memory Functioning in Patients with Bipolar I DisorderAccording to a recent study published in the Journal of Behavior Therapy and Experimental Psychiatry, cognitive behavior therapy (CBT) improves explicit memory recall and reduces explicit memory bias for negative words in patients with bipolar type I disorder. Both mania and depression are associated with impaired memory. In tests in which participants learn words and are then asked to recall them, bipolar patients, both manic and depressive, have been shown to recall less words overall but more words with negative emotional valence than non-bipolar or depressed people. This suggests that bipolar disorder affects global memory performance and introduces a negative memory bias. The present study sought to examine if a CBT intervention would improve global memory performance and reduce the negative memory bias in bipolar I patients using a randomized, wait-list controlled design.. Participants (n=73) were bipolar I patients aged 18-65 on a treatment waiting list. The experimental group (N=53) was ...
Genetic refinement and physical mapping of a 2.3 Mb probable disease region associated with a bipolar affective disorder...A susceptibility locus for bipolar affective disorder has been mapped to chromosome 4q35 in a large multigenerational pedigree. We have expanded this analysis to include 55 pedigrees (674 individuals, 214 affecteds). The evidence for linkage to 4q35 was strengthened in this larger cohort, with a maximum two-point LOD score of 3.2 for marker D4S1652. Several other markers in the region gave LOD scores greater than 1.5. Non-parametric analysis provided additional support for linkage to the 4q35 region. To further refine this region, haplotype analysis was carried out in 16 of the 55 pedigrees that showed evidence of linkage. As there is no evidence for an ancestral haplotype, nor a one-to-one correspondence between the disease and putative disease haplotype, we undertook an analysis based on pedigree-specific, identical-by-descent allele-sharing in order to define a probable disease region. This analysis indicated that the percentage sharing of alleles, identical-by-descent, in affecteds of all linked
Bipolar disorder: Do you keep it secret?Bipolar disorder is classified by experiencing intense highs and lows with your moods. Receiving the news that you have been diagnosed with bipolar disorder can be devastating. Who do you tell -- and when do you tell -- about your disorder? If you have been diagnosed with bipolar disorder, please talk with a professional before disclosing your diagnosis to anyone. Here's why.
Examination of Tamoxifen in Acute Mania in Patients With Bipolar I Disorder - Full Text View - ClinicalTrials.govPatients may be included in the study only if they meet all of the following criteria:. Male and female patients, 18 to 65 years of age. [Note: Only females who are premenopausal with regular menstrual cycles will be able to participate].. Female subjects of childbearing potential must be using a medically accepted means of contraception.. Each patient must have a level of understanding sufficient to agree to all tests and examinations required by the protocol.. Each patient must understand the nature of the study and must sign an informed consent document. We will not permit patients with a Durable Power of Attorney (DPA) to participate in this study. We will however, encourage all patients to sign a DPA after signing the informed consent. However, signing a DPA is not a requirement for participating in this study.. Patients must have a diagnosis of bipolar I disorder and currently display an acute manic or mixed episode (with or without psychotic features) according to the DSM-IV based on ...
New gene linked to bipolar disorder ( A new gene linked to both depression an...)A new gene linked to both depression and bipolar disorder has been ide...The collaboration led by Professor Hugh Gurling at UCL and Professor ...Bipolar disorder is known to run strongly in families but the Slynar ...The Slynar gene is normally found in the brain but in bipolar disorde...Professor Hugh Gurling UCL Department of Mental Health Sciences says...,New,gene,linked,to,bipolar,disorder,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Bipolar Disorder Daily News Blog: Bipolar Disorder Research Study ArchivesBy: Stephanie Kruger, M.D., Martin Alda, M.D., F.R.C.P.C., L. Trevor Young, M.D., Ph.D., F.R.C.P.C., Kim Goldapple, B.S., Saghar Parikh, M.D., F.R.C.P.C., and Helen S. Mayberg, M.D. Published: American Journal of Psychiatry, 163:257-564, February 2006. Purpose of the Study Studies indicate that there is a high level of genetic influence in the development of bipolar disorder, but that it is not the only factor; many people who are genetically predisposed never become bipolar. Yet some scientists believe that although the full blown disorder is never developed, these individuals "manifest traits associated with the illness, namely pathological reactivity to emotional stress." This Read more... ...
Bipolar Disorder: Symptoms & Treatment Guide | Psych CentralBipolar Disorder guide from Psych Central, your trusted source of information. Explore symptoms, resources, and treatment options for Bipolar Disorder.
Information on Vitamin B-12 & Bipolar Disorder | LIVESTRONG.COMThree different types of bipolar disorder exist. In type 1, previously called manic depression, individuals experience full-blown manic episodes and major...
"Polysomnographic characteristics of young manic patients. Comparison w" by James I. Hudson, Joseph F. Lipinski et al.Although sleep disturbance is a prominent feature of mania, its polysomnographic (PSG) features have received little study. To investigate more systematically the PSG characteristics of sleep in mania, all-night PSG evaluations were performed for two to four consecutive nights in 19 young manic patients (age range, 18 to 36 years), 19 age-matched patients with major depression, and 19 age-matched normal control subjects. Manic and depressed patients displayed nearly identical profiles of PSG abnormalities compared with normal control subjects, including disturbed sleep continuity, increased percentage of stage 1 sleep, shortened rapid eye movement latency, and increased rapid eye movement density. These results are similar to those reported in previous studies of major depression, and they are consistent with the possibility that the sleep disturbance in mania and major depression is caused by the same mechanism.
QUANTUM TANTRA: Nick Herbert, the Lonely Ranger of Quantum Tantrafor years I have talked about this - it is simple to send information more fast than light - my friend and I have some particles that have entanglement - I tell my friend to do a measurement of spin at 4 pm with their particles if they want to meet and if my friend does not want to meet do not do a measurement of spin - I leave my friend and I have my particles - my particles have entanglement with particles of my friend - at 4 pm I use things like weak measurement and homodyne to look at my particles to see if my particles have a mixed state - mixed state means my friend did not do a measurement they do not want to meet - if my particles do not have a mixed state my friend did a measurement they want to meet - I am keeping this simple I have a lot of things associated with this that can be used to send information more fast than light Kurt Stocklmeir ...
Treatments for Bipolar Disorder | Psychology TodayBecause bipolar disorder is a recurrent illness, long-term treatment is necessary. Mood stabilizer drugs are typically prescribed to prevent mood swings. Getting the full range of symptoms under control may require other drugs as well either short-term or long-term. Lithium is perhaps the best-known of the mood stabilizers, but newer drugs such as lamotrigene have been shown to cause fewer side effects while frequently obviating the need for antidepressant medication. Used alone, antidepressants can precipitate mania and may accelerate mood cycling.
Clayton Cramer.: Age of Bipolar I Onset Differentials Between USA and EuropeAlong with higher rates of bipolar disorder in the USA, this paper demonstrates that one particular type of bipolar disorder, bipolar I, has an earlier average onset age than in Europe. The paper recognizes that there are possibly some genetic factors involved: perhaps those prone to bipolar I were more likely to immigrate to America; shorter generation time in America may have increased the fraction of the population (especially bipolar disorder and hypersexuality are commonly linked). They do point out that childhood trauma and substance abuse are both associated with the onset of bipolar I, and seem to consider it unnecessary of explication that both of these are a bigger problem in the US than in Europe. That is also my impression -- that American kids are much more likely to be substance abusers than their European counterparts ...
Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodesObjetivo e Método: Existem crescentes evidências indicando que alterações no fator neurotrófico derivado do cérebro e aumento do estresse oxidativo podem estar envolvidos na fisiopatologia do transtorno bipolar. Considerando os achados recentes de que os níveis de fator neurotrófico derivado do cérebro estão diminuídos em situações de aumento de estresse oxidativo, nós testamos a correlação entre os níveis séricos de substâncias reativas do ácido tiobarbitúrico, um índice de peroxidação lipídica, e os níveis séricos de fator neurotrófico derivado do cérebro em pacientes portadores de transtorno bipolar durante mania aguda e em controles saudáveis. Resultados: Os níveis séricos de substâncias reativas do ácido tiobarbitúrico e fator neurotrófico derivado do cérebro apresentaram uma correlação negativa em pacientes bipolares (r = -0,56; p = 0,001), enquanto não houve correlação significativa no grupo controle. Conclusão: Estes resultados sugerem que ...
Bipolar disorder - NHS ChoicesBipolar disorder, previously known as manic depression, is a condition that affects your moods, which can swing from one extreme to another.
Risk Genes for Bipolar Disorder | Bipolar and Related Disorders | JAMA Psychiatry | The JAMA NetworkDima et al determine whether genetic risk for bipolar disorder associated with CACNA1C rs1006737 and ANK3 rs10994336 is mediated through changes in regional act
BBC News - Q&A: Bipolar disorderThe execution in China of a British man said to have bipolar disorder raises questions about how mental illness is recognised and handled.
Flu during pregnancy linked to bipolar disorder in children - Lowell Sun OnlineNEW YORK (Reuters Health) - Children born after being exposed to the flu during pregnancy may have a nearly four-fold higher risk of later developing bipolar disorder, according to a small new study.
The Johns Hopkins Psychiatry NewsletterIn 1999, the more Karen Swartz poked around, asking what people knew about depression, the more shocked she became. A clinician specializing in mood disorders, she had leaned toward genetics research. But that year, a cluster of suicides in Baltimore high schools found Swartz addressing students and their parents at several school assemblies. Afterward, she shook her head. "What struck me was how little people know about depression," she says, "and how even that is often inaccurate." So raw necessity pushed Swartz into public health. With initial financing from concerned Baltimore businesses, she and a nidus of psychiatric nurses and clinicians set up ADAP, the Adolescent Depression Awareness Program. Its aim: to increase basic depression literacy, starting with high-schoolers. Now in its seventh year, ADAP teaches the symptoms of depressive and bipolar illness, distinguishing them from short-term "glooms" or bursts of energy. Students learn how clinicians diagnose and treat depression and ...
Large-scale Roll Out of Online Prospective Measurement of Mood Symptoms in Affective Disorders - Worcester Research and...Background and Aims: True Colours is an online prospective mood-monitoring system developed at the University of Oxford to assist local patients and clinicians with monitoring course of illness in bipolar disorder. We report our initial experiences of using True Colours for research purposes in the Bipolar Disorder Research Network (BDRN; www.bdrn.org), a large research network of individuals with mood disorders spread throughout the UK. Methods: After initial piloting to ensure the practicality/acceptability of using True Colours within BDRN, we invited all BDRN participants (n = 7000) to participate in weekly True Colours ratings via three postal invitations sent over an 8-month period. Results: Following the three postal invitations, 915 individuals have so far expressed an interest in joining True Colours, and, of these, 662 (72.3%) have registered. 32 of those who registered for True Colours (5%) have so far asked to leave the system. Positive feedback from participants has focused ...
Cocaine intoxicationAmidrine: Amidrine, Duradrin, Epidrine, Nodolor or Midrin, is a combination of acetaminophen, dichloralphenazone, and isometheptene used mostly to treat headaches.Crack cocaine: Crack cocaine is the freebase form of cocaine that can be smoked. It may also be termed rock, work, hard, iron, cavvy, base, but is most commonly known as just crack; the Manual of Adolescent Substance Abuse Treatment calls it the most addictive form of cocaine.Dopamine reuptake inhibitor: A dopamine reuptake inhibitor (DRI) is a type of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron.Self-administration: Self-administration is, in its medical sense, the process of a subject administering a pharmacological substance to him-, her-, or itself. A clinical example of this is the subcutaneous "self-injection" of insulin by a diabetic patient.Cue stick: A cue stick (or simply cue, more specifically pool cue, snooker cue, or billiards cue), is an item of sporting equipment essential to the games of pool, snooker and carom billiards. It is used to strike a ball, usually the .Bipolar disorderMental disorderSocial anxiety disorderSchizophreniaBrexpiprazoleAdult attention deficit hyperactivity disorderRelationship obsessive–compulsive disorder: In psychology, relationship obsessive–compulsive disorder (ROCD) is a form of obsessive-compulsive disorder focusing on intimate relationships (whether romantic or non-romantic). Such obsessions can become extremely distressing and debilitating, having negative impacts on relationships functioning.Oneirology: Oneirology (; from Greek [oneiron, "dream"; and -λογία], ["the study of") is the scientific study of [[dream]s. Current research seeks correlations between dreaming and current knowledge about the functions of the brain, as well as understanding of how the brain works during dreaming as pertains to memory formation and mental disorders.Focus on Autism and Other Developmental Disabilities: Focus on Autism and Other Developmental Disabilities is a peer-reviewed academic journal covering the field of special education. The editors-in-chief are Alisa K.
(1/1808) A nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent subjects.
We have previously shown that nicotine enhances cue-induced cocaine craving. In the present study, the effects of a nicotine antagonist, mecamylamine, on cue-induced cocaine craving were investigated. Twenty-three cocaine-dependent patients, all cigarette smokers, were randomly assigned to mecamylamine (2.5 mg tablet) or placebo in a single-dose, placebo-controlled, crossover, double-blind study. Craving and anxiety were measured before and after cocaine cues with visual analog scales for desire to use cocaine and mood. Skin conductance, skin temperature and heart rate were recorded before and during cocaine cues. Following exposure to cocaine cues, all patients reported an increase in cocaine craving and anxiety relative to the precue measures. Cue exposure also produced an increase in skin conductance and decrease in skin temperature. The cue-induced increase in cocaine craving was reduced, while the cue-induced skin conductance and temperature responses were unaffected, by mecamylamine. These findings show that cue-induced cocaine craving is attenuated by mecamylamine. Further study on the use of mecamylamine in relapse prevention programs are suggested. (+info)
(2/1808) Methadone treatment by general practitioners in Amsterdam.
In Amsterdam, a three-tiered program exists to deal with drug use and addiction. General practitioners form the backbone of the system, helping to deal with the majority of addicts, who are not criminals and many of whom desire to be free of addiction. Distinctions are made between drugs with "acceptable" and "unacceptable" risks, and between drug use and drug-related crime; patients who fall into the former categories are treated in a nonconfrontational, nonstigmatizing manner; such a system helps prevent the majority of patients from passing into unacceptable, criminalized categories. The overall program has demonstrated harm reduction both for patients and for the city of Amsterdam. (+info)
(3/1808) Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex?
Although psychoactive drugs are commonly used by AIDS patients, it is unclear whether commonly abused drugs, such as cocaine and ethanol, affect the course of HIV-associated dementia (HADC). Epidemiological studies have resulted in conflicting conclusions as to what role, if any, abused drugs play in HADC. In this review we discuss the clinical and pathological evidence that cocaine and ethanol might exacerbate the detrimental effects of HIV infection on the brain. We also review studies of cocaine and ethanol effects on various components of the immune system both in the presence and absence of retroviral infection. Data from these studies indicate that cocaine and ethanol have profound effects on the immune system that, in many respects, are enhanced by retroviral infection. We conclude that abused drugs likely affect the course of HADC but that proof awaits an examination of their interactive effects in an appropriate in vivo system of retroviral encephalitis. (+info)
(4/1808) Use of illicit drugs among high-school students in Jamaica.
Reported are the results of a survey to assess the prevalence of illicit drug use among high-school students in Jamaica. A total of 2417 high-school students in 26 schools were covered: 1063 boys and 1354 girls of whom 1317 were grade-10 students (mean age 15.7 years) and 1100 were grade-11 students (mean age 16.8 years). Of the students, 1072 and 1345 were from rural and urban schools, respectively, while 1126 and 1291 were children of parents who were professionals and nonprofessionals, respectively. The following drugs were used by the students: marijuana (10.2%), cocaine (2.2%), heroin (1.5%) and opium (1.2%). Illicit drug use among males, urban students and children of professionals was higher than that among females, rural students and children of nonprofessionals, respectively. (+info)
(5/1808) Relative potency of levo-alpha-acetylmethadol and methadone in humans under acute dosing conditions.
levo-alpha-Acetylmethadol (LAAM) and methadone are full mu-opioid agonists used to treat opioid dependence. Current labeling indicates that LAAM is less potent than methadone. Clinical studies have not determined the relative potency of these drugs. This study compared the effects of acute doses of LAAM and methadone and also examined the ability of naloxone to reverse their effects. Five occasional opioid users received once weekly doses of either placebo, LAAM, or methadone (15, 30, or 60 mg/70 kg p.o.) in agonist exposure sessions and then received naloxone (1.0 mg/70 kg i.m.) 24, 72, and 144 h after agonist exposure. Subject-rated, observer-rated, and physiological measures were assessed regularly. Comparisons of physiological and subjective measures collected in agonist exposure sessions indicate that LAAM is not less potent than methadone under acute dosing conditions. For some measures, LAAM was significantly more potent. Three subjects who entered the study were withdrawn for safety reasons due to greater than anticipated and clinically relevant respiratory depression after receiving 60 mg of LAAM. Naloxone did not fully reverse the pupil constriction produced by 60 mg of LAAM. Acute agonist effects suggest that LAAM may be more potent than methadone and more potent than current labeling indicates. An accurate LAAM:methadone relative potency estimate will aid determination of adequate doses for opioid-dependent patients inducted onto LAAM and for methadone maintenance patients who choose to switch to more convenient thrice-weekly LAAM. (+info)
(6/1808) Midfacial complications of prolonged cocaine snorting.
Acute and chronic ingestion of cocaine predisposes the abuser to a wide range of local and systemic complications. This article describes the case of a 38-year-old man whose chronic cocaine snorting resulted in the erosion of the midfacial anatomy and recurrent sinus infections. Previously published case reports specific to this problem are presented, as are the oral, systemic and behavioural effects of cocaine abuse. (+info)
(7/1808) Predicting posttreatment cocaine abstinence for first-time admissions and treatment repeaters.
OBJECTIVES: This study examined client and program characteristics that predict posttreatment cocaine abstinence among cocaine abusers with different treatment histories. METHODS: Cocaine abusers (n = 507) treated in 18 residential programs were interviewed at intake and 1-year follow-up as part of the nationwide Drug Abuse Treatment Outcome Study (DATOS). Program directors provided the program-level data in a mail survey. We applied the hierarchical linear modeling approach for the analysis. RESULTS: No prior treatment and longer retention in DATOS programs were positive predictors of posttreatment abstinence. The interactive effect of these 2 variables was also significantly positive. Program that offered legal services and included recovering staff increased their clients' likelihood of cocaine abstinence. Crack use at both the client and program level predicted negative impact. None of the program variables assessed differentially affected the outcomes of first-timers and repeaters. CONCLUSIONS: Although treatment repeaters were relatively difficult to treat, their likelihood of achieving abstinence was similar to that of first-timers if they were retained in treatment for a sufficient time. First-timers and repeaters responded similarly to the treatment program characteristics examined. The treatment and policy implications of these findings are discussed. (+info)
(8/1808) Effects of contingent and non-contingent cocaine on drug-seeking behavior measured using a second-order schedule of cocaine reinforcement in rats.
Rats were trained to respond with intravenous cocaine as the reinforcer under a fixed interval 15-min schedule, during which conditioned stimuli paired with cocaine were presented contingent on completion of a fixed ratio of 10 responses (i.e., second-order schedule of reinforcement). The effects of contingent and noncontingent cocaine were investigated. The results show that pretreatment with noncontingent (i.e., experimenter-administered) cocaine led to a satiation-like effect that was reflected in decreased numbers of responses and a tendency for an increased latency to initiate responding when the doses of cocaine administered were similar to or higher than the training/maintenance dose of cocaine. By contrast, noncontingent administration of cocaine doses lower than the training/maintenance dose, and response-contingent cocaine administration, led to increased drug-seeking behavior, as reflected in increased numbers of responses. The present data indicate that at least two factors determine whether administration of cocaine would lead to drug-seeking behavior: whether the cocaine administration is contingent or noncontingent, and the relative magnitude of the cocaine dose administered in relation to the training/maintenance dose of cocaine. (+info)
- 1. Women between the ages of 18-60 who meet criteria for current cocaine dependence (DSM-IV-TR). (clinicaltrials.gov)
- Volunteers may meet criteria for abuse or dependence on nicotine, marijuana or alcohol, as long as the dependence is secondary to cocaine dependence and does not require any medical intervention (see additional exclusions for alcohol dependence below). (clinicaltrials.gov)
- Concurrent dependence on cocaine occurs in up to 50% of the over one million opiate dependent patients in spite of methadone maintenance treatment being highly effective for opiate dependence and having excellent treatment retention. (clinicaltrials.gov)
- Cocaine dependence has remained largely unresponsive to medications both in and outside of these methadone programs. (clinicaltrials.gov)
- PARTICIPANTS: Subjects included 100 individuals enrolled in outpatient treatment for cocaine abuse or dependence and 50 community volunteers without histories of drug abuse or other major psychiatric illness and matched to cocaine-dependent patients on age, sex and SES. (omicsonline.org)
reduction in cocaine
- We hypothesize that women in the PROG group will show a greater reduction in cocaine use compared to those in the PBO group. (clinicaltrials.gov)
- The primary outcomes will be reduction in cocaine use as assessed by self-report and thrice-weekly urinalyses. (clinicaltrials.gov)
- Intravenous cocaine use and prior treatment for cocaine abuse predicted particularly low frequency of pleasant activities. (omicsonline.org)
- Wheel-running attenuates intravenous cocaine self-administration in rats: sex differences. (omicsonline.org)
- Abstract This experiment examines the effect of access to a running-wheel on intravenous cocaine self-administration in male and female rats. (omicsonline.org)
- Intravenous cannulae were then implanted, and the rats were trained to self-administer a low dose of cocaine (0.2 mg/kg) under a fixed-ratio (FR 1) schedule during the 6-h sessions, while the wheel remained inactive and cocaine self-administration stabilized (cocaine-only condition). (omicsonline.org)
- The purpose of this study is to evaluate use of risperidone with cocaine abusers. (clinicaltrials.gov)
- Comparison of the frequency and enjoyability of pleasant events in cocaine abusers vs. non-abusers using a standardized behavioral inventory. (omicsonline.org)
- Abstract AIMS: To examine whether cocaine abusers differ from non-abusers in their frequency and enjoyability of engaging in various "pleasant events", in order to approximate the density of positive reinforcement experienced in their natural environment. (omicsonline.org)
- DESIGN: Comparisons of cocaine abusers to normative data and matched controls. (omicsonline.org)
- FINDINGS: Cocaine abusers reliably reported lower frequency of non-social, introverted, passive outdoor and mood-related activities than controls. (omicsonline.org)
- The role of dopamine in mood disorders. (omicsonline.org)
- Abstract The findings on dopamine in mood disorders suggest that decreased dopamine activity is involved in depression, while increased dopamine function contributes to mania. (omicsonline.org)
- We also discuss the importance of integrating these dopamine findings with dopamine brain circuitry and with other neurotransmitter theories of affective disorders. (omicsonline.org)
- Use of a smartphone application to screen for bipolar spectrum disorder in a community sample. (omicsonline.org)
- The specific aim of this study is to evaluate the efficacy of levetiracetam 3 grams/day in modifying cocaine-using behavior, reducing cocaine craving and attenuating cocaine's reinforcing effect among methadone-maintained patients. (clinicaltrials.gov)
- Another cocaine-related efficacy endpoint will be the proportion of patients who achieve at least 2 consecutive weeks of cocaine abstinence (based on urine toxicology results) during the double-blind treatment phase. (clinicaltrials.gov)
- The primary outcome variable was the change from baseline to week 13 of the thrice weekly cocaine-free urine scores. (clinicaltrials.gov)
- In this repeated ordinal variable, 0 represented all 3 urine samples submitted by the subject as positives, 1 represented some urine samples submitted by the subject were negative, and 2 represented all 3 urine samples submitted by the subjects were negative for cocaine. (clinicaltrials.gov)
- Data is summarized as number of participant that were cocaine free urine (score 2) per week by group. (clinicaltrials.gov)
- The purpose of this pilot treatment trial is to evaluate the efficacy of oral micronized PROG in cocaine-dependent women. (clinicaltrials.gov)
- Since we have shown (Evans & Foltin, 2006) that oral micronized PROG attenuates the positive subjective effects of smoked cocaine in females, but not in males, and we have preliminary data indicating that oral micronized PROG also reduces smoked cocaine self-administration in the laboratory, PROG appears to be an ideal potential candidate medication to evaluate in cocaine-dependent women. (clinicaltrials.gov)
- When cocaine infusions were concurrently available, wheel revolutions were reduced by 63.7\% and 61.5\% in males and females, respectively, compared to the wheel-only condition. (omicsonline.org)
- These results indicate that wheel-running activity had a greater suppressant effect on cocaine self-administration in females than in males, and in females, wheel-running and cocaine self-administration are substitutable as reinforcers. (omicsonline.org)
- The VAS measures the intensity of cocaine craving with a scale from 0 (No desire at all) to 7 (Unable to resist), and frequency of cocaine craving in the previous 24 hours with a scale from 0 ( never) to 7 ( all the time). (clinicaltrials.gov)
- Tertiary Aims: To conduct exploratory analyses to determine whether 1) trauma history is related to treatment outcomes and 2) improvements in treatment outcome measures are related to decreases in HIV high-risk behaviors. (clinicaltrials.gov)
- Secondary outcomes will include weeks in treatment (retention) and change in measures of cocaine craving, anxiety symptoms and opiate withdrawal symptoms. (clinicaltrials.gov)
- These differences remained after controlling for demographic and life-style differences between groups, with the exception of mood-related activities. (omicsonline.org)
- We have initial data from our open-label study with levetiracetam showing that this medication is well tolerated and may reduce cocaine use in this cocaine-abusing methadone treated population. (clinicaltrials.gov)
- Prior to randomization to treatment, women will reside inpatient for one week to ensure cocaine abstinence since one of the primary outcome measures will be time to cocaine relapse. (clinicaltrials.gov)
- Relatively unique to cocaine treatment trials, one of the principal outcome measures will be time to cocaine relapse. (clinicaltrials.gov)
- Lastly, the proportion of cocaine-negative urines collected throughout the treatment trial will be measured. (clinicaltrials.gov)
- Find phone numbers, addresses and information about Cocaine Treatment Center in Bowling Green. (directorym.com)
- Find phone numbers, addresses and information about Treatment for Eating Disorders in Bowling Green. (directorym.com)
- Cocaine use history, treatment outcome and other relevant variables were also assessed. (omicsonline.org)
- Abstract Although the involvement of the medial prefrontal cortex projection to the nucleus accumbens in the reinstatement of cocaine seeking has been well studied, it is not known if this projection plays a similar role in the reinstatement of cue- and methamphetamine-induced drug seeking in animals extinguished from methamphetamine self-administration. (omicsonline.org)
- Next, the wheel access and cocaine self-administration were concurrently available followed by a period of cocaine-only. (omicsonline.org)
- Similar to cocaine seeking, inactivation of either the prelimbic cortex or accumbens core eliminated cue- and methamphetamine-induced reinstatement, and inactivation of neither the infralimbic cortex nor shell subcompartments inhibited methamphetamine-induced drug seeking. (omicsonline.org)
- In conclusion, although a primary role in reinstated drug seeking by the prelimbic and the accumbens core is similar between cocaine and methamphetamine, the recruitment of the infralimbic cortex by conditioned cues differs between these two psychostimulant drugs. (omicsonline.org)
- However, in contrast to previous reports with cocaine, cue-induced reinstatement of methamphetamine seeking was inhibited by inactivation of the infralimbic cortex. (omicsonline.org)