Cisterna Magna
Fourth Ventricle
Dandy-Walker Syndrome
Vasospasm, Intracranial
Subarachnoid Space
Paraparesis, Spastic
Subarachnoid Hemorrhage
Basilar Artery
Platybasia
Cerebral Ventricles
Arnold-Chiari Malformation
Cerebrospinal Fluid
Injections, Spinal
Septum of Brain
Echoencephalography
Intracranial Pressure
Syringomyelia
Cranial Fossa, Posterior
Golgi Apparatus
Ultrasonography, Prenatal
Fetal Diseases
Hydrocephalus
Fasciolidae
Dogs
Pregnancy Trimester, Second
Cats
Rabbits
Microscopy, Electron
Brain
Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation. (1/221)
1. The aim of the present study was to analyse the cardiovascular actions of the synthetic CB1/CB2 cannabinoid receptor agonist WIN55212-2, and specifically to determine its sites of action on sympathetic cardiovascular regulation. 2. Pithed rabbits in which the sympathetic outflow was continuously stimulated electrically or which received a pressor infusion of noradrenaline were used to study peripheral prejunctional and direct vascular effects, respectively. For studying effects on brain stem cardiovascular regulatory centres, drugs were administered into the cisterna cerebellomedullaris in conscious rabbits. Overall cardiovascular effects of the cannabinoid were studied in conscious rabbits with intravenous drug administration. 3. In pithed rabbits in which the sympathetic outflow was continuously electrically stimulated, intravenous injection of WIN55212-2 (5, 50 and 500 microg kg(-1)) markedly reduced blood pressure, the spillover of noradrenaline into plasma and the plasma noradrenaline concentration, and these effects were antagonized by the CB1 cannabinoid receptor-selective antagonist SR141716A. The hypotensive and the sympathoinhibitory effect of WIN55212-2 was shared by CP55940, another mixed CB1/CB2 cannabinoid receptor agonist, but not by WIN55212-3, the enantiomer of WIN55212-2, which lacks affinity for cannabinoid binding sites. WIN55212-2 had no effect on vascular tone established by infusion of noradrenaline in pithed rabbits. 4. Intracisternal application of WIN55212-2 (0.1, 1 and 10 microg kg(-1)) in conscious rabbits increased blood pressure and the plasma noradrenaline concentration and elicited bradycardia; this latter effect was antagonized by atropine. 5. In conscious animals, intravenous injection of WIN55212-2 (5 and 50 microg kg(-1)) caused bradycardia, slight hypotension, no change in the plasma noradrenaline concentration, and an increase in renal sympathetic nerve firing. The highest dose of WIN55212-2 (500 microg kg(-1)) elicited hypotension and tachycardia, and sympathetic nerve activity and the plasma noradrenaline concentration declined. 6. The results obtained in pithed rabbits indicate that activation of CB1 cannabinoid receptors leads to marked peripheral prejunctional inhibition of noradrenaline release from postganglionic sympathetic axons. Intracisternal application of WIN55212-2 uncovered two effects on brain stem cardiovascular centres: sympathoexcitation and activation of cardiac vagal fibres. The highest dose of systemically administered WIN55212-2 produced central sympathoinhibition; the primary site of this action is not known. (+info)Evaluation of CSF leaks: high-resolution CT compared with contrast-enhanced CT and radionuclide cisternography. (2/221)
BACKGROUND AND PURPOSE: Radiologic evaluation of CSF leaks is a diagnostic challenge that often involves multiple imaging studies with the associated expense and patient discomfort. We evaluated the use of screening noncontrast high-resolution CT in identifying the presence and site of CSF rhinorrhea and otorrhea and compared it with contrast-enhanced CT cisternography and radionuclide cisternography. METHODS: We retrospectively reviewed the imaging studies and medical records of all patients who were evaluated for CSF leak during a 7-year period. Forty-two patients with rhinorrhea and/or otorrhea underwent high-resolution CT of the face or temporal bone and then had CT cisternography and radionuclide cisternography via lumbar puncture. The results of the three studies were compared and correlated with the surgical findings in 21 patients. RESULTS: High-resolution CT showed bone defects in 30 of 42 patients (71%) with CSF leak. High-resolution, radionuclide cisternography and CT cisternography did not show bone defects or CSF leak for 12 patients (29%) who had clinical evidence of CSF leak. Among the 30 patients with bone defects, 20 (66%) had positive results of their radionuclide cisternography and/or CT cisternography. For the 21 patients who underwent surgical exploration and repair, intraoperative findings correlated with the defects revealed by high-resolution CT in all cases. High-resolution CT identified significantly more patients with CSF leak than did radionuclide cisternography and CT cisternography, with a moderate degree of agreement. CONCLUSION: Noncontrast high-resolution CT showed a defect in 70% of the patients with CSF leak. No radionuclide cisternography or CT cisternography study produced positive results without previous visualization of a defect on high-resolution CT. CT cisternography and radionuclide cisternography may be reserved for patients in whom initial high-resolution CT does not identify a bone defect or for patients with multiple fractures or postoperative defects. (+info)Spontaneous cerebrospinal fluid leakage detected by magnetic resonance cisternography--case report. (3/221)
A 49-year-old male with no history of head trauma suffered cerebrospinal fluid (CSF) discharge from the left nostril for one month. Coronal computed tomography (CT) showed lateral extension of the sphenoid sinus on both sides and CSF collection on the left side. CT cisternography could not identify the site of CSF leakage. Heavily T2-weighted magnetic resonance (MR) imaging (MR cisternography) in the coronal plane clearly delineated a fistulous tract through the sphenoid bone into the sphenoid sinus. Patch graft with muscle fragment completely relieved the CSF rhinorrhea. Postoperative three-dimensional CT showed the two bone defects identified during surgery. Small bony dehiscences in the sphenoid bone and lateral extension of the sphenoid sinus predisposed the present patient to CSF fistula formation. MR cisternography in the coronal and sagittal planes is superior to CT scanning or CT cisternography for detection of the site of active CSF leakage. (+info)Peripheral injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. (4/221)
The effect of the corticotropin-releasing factor (CRF) receptor antagonists astressin and D-Phe CRF(12-41) injected i.v. on CRF-induced delayed gastric emptying (GE) was investigated in conscious rats. Gastric transit was assessed by the recovery of methyl cellulose/phenol red solution 20 min after its intragastric administration. The 55% inhibition of GE induced by CRF (0.6 microgram i.v.) was antagonized by 87 and 100% by i.v. astressin at 3 and 10 microgram, respectively, and by 68 and 64% by i.v. D-Phe CRF(12-41) at 10 and 20 microgram, respectively. CRF (0.6 microgram)-injected intracisternally (i.c.) induced 68% reduction of GE was not modified by i.v. astressin (10 microgram) whereas i.c. astressin (3 or 10 microgram) blocked by 58 and 100%, respectively, i.v. CRF inhibitory action. Abdominal surgery with cecal manipulation reduced GE to 7.1 +/- 3.1 and 27.5 +/- 3.3% at 30 and 180 min postsurgery, respectively, compared with 40.3 +/- 4.3 and 59.5 +/- 2.9% at similar times after anesthesia alone. Astressin (3 microgram i.v.) completely and D-Phe CRF(12-41) (20 microgram i.v.) partially (60%) blocked surgery-induced gastric stasis observed at 30 or 180 min. The CRF antagonists alone (i.v. or i.c.) had no effect on basal GE. These data indicate that CRF acts in the brain and periphery to inhibit GE through receptor-mediated interaction and that peripheral CRF is involved in acute postoperative gastric ileus; astressin is a potent peripheral antagonist of CRF when injected i.v. whereas i.c. doses >/=3 microgram exert dual central and peripheral blockade of CRF action on gastric transit. (+info)HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system. (5/221)
Recombinant HIV-1 Nef protein, but not Tat, gp120, and gp160, provoked leukocyte recruitment into the CNS in a rat model. The strong reduction of bioactivity by heat treatment of Nef, and the blocking effect of the mAb 2H12, which recognizes the carboxy-terminal amino acid (aa) residues 171-190 (but not of mAb 3E6, an anti-Nef Ab of the same isotype, which maps the aa sequence 168-175, as well as a mixture of mAbs to CD4) provided evidence for the specificity of the observed Nef effects. Using a modified Boyden chamber technique, Nef exhibited chemotactic activity on mononuclear cells in vitro. Coadministration of the anti-Nef mAb 2H12, as well as treatment of Nef by heat inhibited Nef-induced chemotaxis. Besides soluble Nef, chemotaxis was also induced by a Nef-expressing human astrocytoma cell line, but not by control cells. These data suggest a direct chemotactic activity of soluble Nef. The detection of elevated levels of IL-6, TNF-alpha, and IFN-gamma in rat cerebrospinal fluid 6 h after intracisternal Nef injection hint at the additional involvement of indirect mechanisms in Nef-induced leukocyte migration into rat CNS. These data propose a mechanism by which HIV-1 Nef protein may be essential for AIDS neuropathogenesis, as a mediator of the recruitment of leukocytes that may serve as vehicles of the virus and perpetrators for disease through their production of neurotoxins. (+info)High-resolution MR cisternography of the cerebellopontine angle, obtained with a three-dimensional fast asymmetric spin-echo sequence in a 0.35-T open MR imaging unit. (6/221)
High-resolution MR cisternography performed with 3D fast asymmetric spin-echo imaging (3D fast spin-echo with an ultra-long echo train length and asymmetric Fourier imaging) was optimized in a 0.35-T open MR imaging unit. The 0.35- and 1.5-T images of the two volunteers and three patients with acoustic schwannomas were then compared. The optimal parameters for images obtained by 3D fast asymmetric spin-echo imaging at 0.35 T were as follows: field of view, 15 cm; matrix, 256 x 256 x 40; section thickness, 1 mm; echo train length, 76; and imaging time, 10 minutes 44 seconds. Scans obtained from both normal volunteers showed the facial, cochlear, and superior and inferior vestibular nerves separately in the internal auditory canal on both 0.35- and 1.5-T images. All three acoustic schwannomas were depicted on both 0.35- and 1.5-T images. Screening for disease at the cerebellopontine angle and in the internal auditory canal, without the administration of contrast material on a low-field open MR imaging unit and within a clinically acceptable imaging time, may be possible. Further controlled prospective studies are required, however, before implementation on a wide basis. If proved effective, this may be of particular value for reducing healthcare costs and for imaging claustrophobic and pediatric patients in an open system. (+info)Neurodevelopmental outcome after antenatal diagnosis of posterior fossa abnormalities. (7/221)
Posterior fossa abnormalities are sonographically diagnosable in the fetus. Anomalies of this region include Dandy-Walker malformation, enlarged cisterna magna, and arachnoid cyst. Despite prenatal diagnosis, the uncertainties related to natural history and neurodevelopmental outcome in survivors make patient counseling difficult. The purposes of this study were to determine the accuracy of prenatal diagnosis of these lesions and elucidate long-term neurodevelopmental outcome in survivors in prenatally diagnosed posterior fossa abnormalities. Fifteen cases of posterior fossa abnormalities were reviewed. Antenatal diagnoses of Dandy-Walker malformation was made in 13 of these cases, arachnoid cyst in one case, and enlarged cisterna magna in one case. Hydrocephalus was present in 66% of patients. The sonographic diagnosis was concordant with the pathologic or neonatal radiologic diagnosis in 13 of 15 cases. Seven fetuses (47%) exhibited additional cranial or extracranial anomalies. A karyotypic abnormality (trisomy 18) was found in one of 15 cases of posterior fossa abnormalities. Neurodevelopmental delay was present in 80% of survivors with follow-up study to 4 years of age. Prenatal diagnosis of posterior fossa abnormalities is highly accurate, yet the differential diagnosis can be challenging. Cognitive and psychomotor developmental delays remain commonplace despite early diagnosis and treatment. The approach with families in cases of prenatal diagnosis of posterior fossa abnormalities should include a search for additional central nervous system and extra-central nervous system anomalies in the fetus and counseling of parents regarding potential adverse outcome for survivors. (+info)Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys. (8/221)
Systemic administration of nor-binaltorphimine (nor-BNI) produces a long-lasting kappa-opioid receptor (kappaOR) antagonism and has kappa(1)-selectivity in nonhuman primates. The aim of this study was to establish the pharmacological basis of central kappaOR antagonism in rhesus monkeys (Macaca mulatta). After intracisternal (i.c.) administration of small doses of nor-BNI, the duration and selectivity of nor-BNI antagonism were evaluated against two kappaOR agonists, (trans)-3, 4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide (U50,488) and bremazocine. Thermal antinociception was measured in the warm water (50 degrees C) tail-withdrawal assay and sedation was evaluated by observers blind to treatment conditions. Following i.c. pretreatment with 0.32 mg nor-BNI, a 5- to 10-fold rightward shift of the U50,488 baseline dose-effect curve was observed in antinociception. In contrast, this dose of nor-BNI only produced an insignificant 2-fold shift against bremazocine. Pretreatment with a smaller dose (0.032 mg) of nor-BNI produced a 3-fold shift of U50, 488, which lasted for 7 days, but failed to alter the potency of bremazocine. This differential antagonism profile of i.c. nor-BNI also was observed in sedation ratings. In addition, the centrally effective dose of nor-BNI (0.32 mg), when administered s.c. in the back, did not antagonize either U50,488- or bremazocine-induced antinociception and sedation. After i.c. pretreatment with the same dose, nor-BNI also did not antagonize the peripherally mediated effect of U50,488 against capsaicin-induced thermal nociception in the tail. These results indicate that i.c. nor-BNI produces central kappaOR antagonism and support the notion of two functional kappaOR subtypes in the central nervous system. Moreover, it provides a valuable pharmacological basis for further characterizing different sources of kappaOR-mediated effects, namely, from central or peripheral nervous system receptors. (+info)The term "cisterna magna" is derived from Latin, where "cisterna" means "reservoir" or "receptacle," and "magna" means "large." In medical anatomy, the cisterna magna refers to a large, sac-like space located near the lower part of the brainstem. It is a subarachnoid cistern, which means it is a space that contains cerebrospinal fluid (CSF) between the arachnoid and pia mater membranes covering the brain and spinal cord.
More specifically, the cisterna magna is situated between the cerebellum (the lower part of the brain responsible for coordinating muscle movements and maintaining balance) and the occipital bone (the bone at the back of the skull). This space contains a significant amount of CSF, which serves as a protective cushion for the brain and spinal cord, helps regulate intracranial pressure, and facilitates the circulation of nutrients and waste products.
The cisterna magna is an essential structure in neurosurgical procedures and diagnostic imaging techniques like lumbar puncture (spinal tap) or myelograms, where contrast agents are introduced into the CSF to visualize the spinal cord and surrounding structures. Additionally, it serves as a crucial landmark for various surgical approaches to the posterior fossa (the lower part of the skull that houses the cerebellum and brainstem).
The fourth ventricle is a part of the cerebrospinal fluid-filled system in the brain, located in the posterior cranial fossa and continuous with the central canal of the medulla oblongata and the cerebral aqueduct. It is shaped like a cavity with a roof, floor, and lateral walls, and it communicates rostrally with the third ventricle through the cerebral aqueduct and caudally with the subarachnoid space through the median and lateral apertures (foramina of Luschka and Magendie). The fourth ventricle contains choroid plexus tissue, which produces cerebrospinal fluid. Its roof is formed by the cerebellar vermis and the superior medullary velum, while its floor is composed of the rhomboid fossa, which includes several important structures such as the vagal trigone, hypoglossal trigone, and striae medullares.
Dandy-Walker Syndrome is a congenital brain malformation characterized by the absence or underdevelopment of the cerebellar vermis (the part of the brain that helps coordinate movement) and an enlarged fluid-filled space (fourth ventricle) surrounding it. This condition can also be associated with an upward bulging of the back of the skull (occipital bone), and in some cases, hydrocephalus (excessive accumulation of cerebrospinal fluid in the brain). The syndrome can vary in severity, and symptoms may include problems with balance, coordination, developmental delays, and increased intracranial pressure. It is usually diagnosed through imaging tests such as ultrasound, CT scan, or MRI. Treatment typically involves managing symptoms and addressing complications, which may include surgical procedures to relieve hydrocephalus if present.
Intracranial vasospasm is a medical condition characterized by the narrowing or constriction of the intracranial arteries, which are the blood vessels that supply blood to the brain. This narrowing is usually caused by the contraction or spasming of the smooth muscle in the walls of the arteries, leading to reduced blood flow and oxygen delivery to the brain tissue.
Intracranial vasospasm is often associated with subarachnoid hemorrhage (SAH), a type of stroke caused by bleeding in the space surrounding the brain. SAH can cause the release of blood components, such as hemoglobin and iron, which can irritate and damage the walls of the arteries. This irritation can trigger an inflammatory response that leads to the contraction of the smooth muscle in the artery walls, causing vasospasm.
Vasospasm can cause further ischemia (reduced blood flow) or infarction (tissue death) in the brain, leading to serious neurological deficits or even death. Therefore, prompt diagnosis and treatment of intracranial vasospasm are crucial for improving patient outcomes. Treatment options may include medications to dilate the blood vessels, angioplasty (balloon dilation) or stenting procedures to mechanically open up the arteries, or surgical intervention to relieve pressure on the brain.
The subarachnoid space is the area between the arachnoid mater and pia mater, which are two of the three membranes covering the brain and spinal cord (the third one being the dura mater). This space is filled with cerebrospinal fluid (CSF), which provides protection and cushioning to the central nervous system. The subarachnoid space also contains blood vessels that supply the brain and spinal cord with oxygen and nutrients. It's important to note that subarachnoid hemorrhage, a type of stroke, can occur when there is bleeding into this space.
Paraparesis, spastic type, is a medical term used to describe a condition characterized by partial weakness or loss of voluntary movement in the lower extremities (legs). The term "paraparesis" comes from Greek words "para" meaning beside or beyond, and "paresis" meaning loosening or relaxation.
In spastic paraparesis, the muscle tone is increased, causing stiffness and resistance to movement, particularly during quick or forceful movements. This increased muscle tone, also known as spasticity, results from an upper motor neuron lesion in the brain or spinal cord that affects the corticospinal tract, which carries signals from the brain to the muscles.
Spastic paraparesis can be caused by various conditions, including spinal cord injuries, multiple sclerosis, hereditary spastic paraplegia, and stroke, among others. The severity of symptoms may vary widely, ranging from mild weakness to complete paralysis. Treatment options for spastic paraparesis depend on the underlying cause and may include physical therapy, medications, surgery, or a combination of these approaches.
A subarachnoid hemorrhage is a type of stroke that results from bleeding into the space surrounding the brain, specifically within the subarachnoid space which contains cerebrospinal fluid (CSF). This space is located between the arachnoid membrane and the pia mater, two of the three layers that make up the meninges, the protective covering of the brain and spinal cord.
The bleeding typically originates from a ruptured aneurysm, a weakened area in the wall of a cerebral artery, or less commonly from arteriovenous malformations (AVMs) or head trauma. The sudden influx of blood into the CSF-filled space can cause increased intracranial pressure, irritation to the brain, and vasospasms, leading to further ischemia and potential additional neurological damage.
Symptoms of a subarachnoid hemorrhage may include sudden onset of severe headache (often described as "the worst headache of my life"), neck stiffness, altered mental status, nausea, vomiting, photophobia, and focal neurological deficits. Rapid diagnosis and treatment are crucial to prevent further complications and improve the chances of recovery.
The basilar artery is a major blood vessel that supplies oxygenated blood to the brainstem and cerebellum. It is formed by the union of two vertebral arteries at the lower part of the brainstem, near the junction of the medulla oblongata and pons.
The basilar artery runs upward through the center of the brainstem and divides into two posterior cerebral arteries at the upper part of the brainstem, near the midbrain. The basilar artery gives off several branches that supply blood to various parts of the brainstem, including the pons, medulla oblongata, and midbrain, as well as to the cerebellum.
The basilar artery is an important part of the circle of Willis, a network of arteries at the base of the brain that ensures continuous blood flow to the brain even if one of the arteries becomes blocked or narrowed.
Platybasia is a medical term that refers to a condition where the base of the skull is flattened or broadened, resulting in an abnormal increase in the angle between the clivus (a part of the sphenoid bone) and the posterior aspect of the upper surface of the palatine bone. This condition can be congenital or acquired and is often associated with other skeletal abnormalities. In some cases, platybasia may lead to neurological symptoms such as headaches, neck pain, or even brainstem compression.
The cerebral ventricles are a system of interconnected fluid-filled cavities within the brain. They are located in the center of the brain and are filled with cerebrospinal fluid (CSF), which provides protection to the brain by cushioning it from impacts and helping to maintain its stability within the skull.
There are four ventricles in total: two lateral ventricles, one third ventricle, and one fourth ventricle. The lateral ventricles are located in each cerebral hemisphere, while the third ventricle is located between the thalami of the two hemispheres. The fourth ventricle is located at the base of the brain, above the spinal cord.
CSF flows from the lateral ventricles into the third ventricle through narrow passageways called the interventricular foramen. From there, it flows into the fourth ventricle through another narrow passageway called the cerebral aqueduct. CSF then leaves the fourth ventricle and enters the subarachnoid space surrounding the brain and spinal cord, where it can be absorbed into the bloodstream.
Abnormalities in the size or shape of the cerebral ventricles can indicate underlying neurological conditions, such as hydrocephalus (excessive accumulation of CSF) or atrophy (shrinkage) of brain tissue. Imaging techniques, such as computed tomography (CT) or magnetic resonance imaging (MRI), are often used to assess the size and shape of the cerebral ventricles in clinical settings.
Arnold-Chiari malformation is a structural abnormality of the brain and skull base, specifically the cerebellum and brainstem. It is characterized by the descent of the cerebellar tonsils and sometimes parts of the brainstem through the foramen magnum (the opening at the base of the skull) into the upper spinal canal. This can cause pressure on the brainstem and cerebellum, potentially leading to a range of symptoms such as headaches, neck pain, unsteady gait, swallowing difficulties, hearing or balance problems, and in severe cases, neurological deficits. There are four types of Arnold-Chiari malformations, with type I being the most common and least severe form. Types II, III, and IV are progressively more severe and involve varying degrees of hindbrain herniation and associated neural tissue damage. Surgical intervention is often required to alleviate symptoms and prevent further neurological deterioration.
Cerebrospinal fluid (CSF) is a clear, colorless fluid that surrounds and protects the brain and spinal cord. It acts as a shock absorber for the central nervous system and provides nutrients to the brain while removing waste products. CSF is produced by specialized cells called ependymal cells in the choroid plexus of the ventricles (fluid-filled spaces) inside the brain. From there, it circulates through the ventricular system and around the outside of the brain and spinal cord before being absorbed back into the bloodstream. CSF analysis is an important diagnostic tool for various neurological conditions, including infections, inflammation, and cancer.
Intraventricular injections are a type of medical procedure where medication is administered directly into the cerebral ventricles of the brain. The cerebral ventricles are fluid-filled spaces within the brain that contain cerebrospinal fluid (CSF). This procedure is typically used to deliver drugs that target conditions affecting the central nervous system, such as infections or tumors.
Intraventricular injections are usually performed using a thin, hollow needle that is inserted through a small hole drilled into the skull. The medication is then injected directly into the ventricles, allowing it to circulate throughout the CSF and reach the brain tissue more efficiently than other routes of administration.
This type of injection is typically reserved for situations where other methods of drug delivery are not effective or feasible. It carries a higher risk of complications, such as bleeding, infection, or damage to surrounding tissues, compared to other routes of administration. Therefore, it is usually performed by trained medical professionals in a controlled clinical setting.
Spinal injections, also known as epidural injections or intrathecal injections, are medical procedures involving the injection of medications directly into the spinal canal. The medication is usually delivered into the space surrounding the spinal cord (the epidural space) or into the cerebrospinal fluid that surrounds and protects the spinal cord (the subarachnoid space).
The medications used in spinal injections can include local anesthetics, steroids, opioids, or a combination of these. The purpose of spinal injections is to provide diagnostic information, therapeutic relief, or both. They are commonly used to treat various conditions affecting the spine, such as radicular pain (pain that radiates down the arms or legs), disc herniation, spinal stenosis, and degenerative disc disease.
Spinal injections can be administered using different techniques, including fluoroscopy-guided injections, computed tomography (CT) scan-guided injections, or with the help of a nerve stimulator. These techniques ensure accurate placement of the medication and minimize the risk of complications.
It is essential to consult a healthcare professional for specific information regarding spinal injections and their potential benefits and risks.
The term "septum" in the context of the brain refers to the septal nuclei, which are a collection of neurons located in the basal forebrain. Specifically, they make up the septal area, which is part of the limbic system and plays a role in reward, reinforcement, and positive motivational states.
There isn't a structure called the "septum of brain" in medical terminology. However, there are several structures in the brain that contain a septum or have a partitioning septum within them, such as:
1. Septal nuclei (as mentioned above)
2. The nasal septum, which is a thin wall of bone and cartilage that separates the two nostrils in the nose
3. The interventricular septum, which is a thin muscular wall that separates the left and right lateral ventricles within the brain
4. The membranous septum, a part of the heart's structure that separates the left and right ventricles
Confusion might arise due to the term "septum" being used in different contexts. In this case, there is no specific medical definition for 'Septum of Brain'.
Echoencephalography (EEG) is a type of neurosonology technique that uses ultrasound to assess the structures of the brain and detect any abnormalities. It is also known as brain ultrasound or transcranial Doppler ultrasound. This non-invasive procedure involves placing a small ultrasound probe on the skull, which emits sound waves that travel through the skull and bounce back (echo) when they reach the brain tissue. The resulting echoes are then analyzed to create images of the brain's structures, including the ventricles, cerebral arteries, and other blood vessels.
EEG is often used in infants and young children, as their skulls are still thin enough to allow for clear ultrasound imaging. It can help diagnose conditions such as hydrocephalus (fluid buildup in the brain), intracranial hemorrhage (bleeding in the brain), stroke, and other neurological disorders. EEG is a safe and painless procedure that does not require any radiation or contrast agents, making it an attractive alternative to other imaging techniques such as CT or MRI scans. However, its use is limited in older children and adults due to the thickening of the skull bones, which can make it difficult to obtain clear images.
Intracranial pressure (ICP) is the pressure inside the skull and is typically measured in millimeters of mercury (mmHg). It's the measurement of the pressure exerted by the cerebrospinal fluid (CSF), blood, and brain tissue within the confined space of the skull.
Normal ICP ranges from 5 to 15 mmHg in adults when lying down. Intracranial pressure may increase due to various reasons such as bleeding in the brain, swelling of the brain, increased production or decreased absorption of CSF, and brain tumors. Elevated ICP is a serious medical emergency that can lead to brain damage or even death if not promptly treated. Symptoms of high ICP may include severe headache, vomiting, altered consciousness, and visual changes.
Syringomyelia is a medical condition characterized by the formation of a fluid-filled cavity or cavities (syrinx) within the spinal cord. This syrinx can lead to various symptoms depending on its size and location, which may include pain, muscle weakness, numbness, and stiffness in the neck, back, shoulders, arms, or legs. In some cases, it may also affect bladder and bowel function, sexual performance, and the ability to maintain normal body temperature. Syringomyelia is often associated with Chiari malformation, a condition where the lower part of the brain extends into the spinal canal. However, other conditions such as spinal cord injuries, tumors, or infections may also cause syringomyelia.
The posterior cranial fossa is a term used in anatomy to refer to the portion of the skull that forms the lower, back part of the cranial cavity. It is located between the occipital bone and the temporal bones, and it contains several important structures including the cerebellum, pons, medulla oblongata, and the lower cranial nerves (IX-XII). The posterior fossa also contains the foramen magnum, which is a large opening through which the spinal cord connects to the brainstem. This region of the skull is protected by the occipital bone, which forms the base of the skull and provides attachment for several neck muscles.
The Golgi apparatus, also known as the Golgi complex or simply the Golgi, is a membrane-bound organelle found in the cytoplasm of most eukaryotic cells. It plays a crucial role in the processing, sorting, and packaging of proteins and lipids for transport to their final destinations within the cell or for secretion outside the cell.
The Golgi apparatus consists of a series of flattened, disc-shaped sacs called cisternae, which are stacked together in a parallel arrangement. These stacks are often interconnected by tubular structures called tubules or vesicles. The Golgi apparatus has two main faces: the cis face, which is closest to the endoplasmic reticulum (ER) and receives proteins and lipids directly from the ER; and the trans face, which is responsible for sorting and dispatching these molecules to their final destinations.
The Golgi apparatus performs several essential functions in the cell:
1. Protein processing: After proteins are synthesized in the ER, they are transported to the cis face of the Golgi apparatus, where they undergo various post-translational modifications, such as glycosylation (the addition of sugar molecules) and sulfation. These modifications help determine the protein's final structure, function, and targeting.
2. Lipid modification: The Golgi apparatus also modifies lipids by adding or removing different functional groups, which can influence their properties and localization within the cell.
3. Protein sorting and packaging: Once proteins and lipids have been processed, they are sorted and packaged into vesicles at the trans face of the Golgi apparatus. These vesicles then transport their cargo to various destinations, such as lysosomes, plasma membrane, or extracellular space.
4. Intracellular transport: The Golgi apparatus serves as a central hub for intracellular trafficking, coordinating the movement of vesicles and other transport carriers between different organelles and cellular compartments.
5. Cell-cell communication: Some proteins that are processed and packaged in the Golgi apparatus are destined for secretion, playing crucial roles in cell-cell communication and maintaining tissue homeostasis.
In summary, the Golgi apparatus is a vital organelle involved in various cellular processes, including post-translational modification, sorting, packaging, and intracellular transport of proteins and lipids. Its proper functioning is essential for maintaining cellular homeostasis and overall organismal health.
An injection is a medical procedure in which a medication, vaccine, or other substance is introduced into the body using a needle and syringe. The substance can be delivered into various parts of the body, including into a vein (intravenous), muscle (intramuscular), under the skin (subcutaneous), or into the spinal canal (intrathecal or spinal).
Injections are commonly used to administer medications that cannot be taken orally, have poor oral bioavailability, need to reach the site of action quickly, or require direct delivery to a specific organ or tissue. They can also be used for diagnostic purposes, such as drawing blood samples (venipuncture) or injecting contrast agents for imaging studies.
Proper technique and sterile conditions are essential when administering injections to prevent infection, pain, and other complications. The choice of injection site depends on the type and volume of the substance being administered, as well as the patient's age, health status, and personal preferences.
Prenatal ultrasonography, also known as obstetric ultrasound, is a medical diagnostic procedure that uses high-frequency sound waves to create images of the developing fetus, placenta, and amniotic fluid inside the uterus. It is a non-invasive and painless test that is widely used during pregnancy to monitor the growth and development of the fetus, detect any potential abnormalities or complications, and determine the due date.
During the procedure, a transducer (a small handheld device) is placed on the mother's abdomen and moved around to capture images from different angles. The sound waves travel through the mother's body and bounce back off the fetus, producing echoes that are then converted into electrical signals and displayed as images on a screen.
Prenatal ultrasonography can be performed at various stages of pregnancy, including early pregnancy to confirm the pregnancy and detect the number of fetuses, mid-pregnancy to assess the growth and development of the fetus, and late pregnancy to evaluate the position of the fetus and determine if it is head down or breech. It can also be used to guide invasive procedures such as amniocentesis or chorionic villus sampling.
Overall, prenatal ultrasonography is a valuable tool in modern obstetrics that helps ensure the health and well-being of both the mother and the developing fetus.
Fetal diseases are medical conditions or abnormalities that affect a fetus during pregnancy. These diseases can be caused by genetic factors, environmental influences, or a combination of both. They can range from mild to severe and may impact various organ systems in the developing fetus. Examples of fetal diseases include congenital heart defects, neural tube defects, chromosomal abnormalities such as Down syndrome, and infectious diseases such as toxoplasmosis or rubella. Fetal diseases can be diagnosed through prenatal testing, including ultrasound, amniocentesis, and chorionic villus sampling. Treatment options may include medication, surgery, or delivery of the fetus, depending on the nature and severity of the disease.
Hydrocephalus is a medical condition characterized by an abnormal accumulation of cerebrospinal fluid (CSF) within the brain, leading to an increase in intracranial pressure and potentially causing damage to the brain tissues. This excessive buildup of CSF can result from either overproduction or impaired absorption of the fluid, which typically causes the ventricles (fluid-filled spaces) inside the brain to expand and put pressure on surrounding brain structures.
The condition can be congenital, present at birth due to genetic factors or abnormalities during fetal development, or acquired later in life as a result of injuries, infections, tumors, or other disorders affecting the brain's ability to regulate CSF flow and absorption. Symptoms may vary depending on age, severity, and duration but often include headaches, vomiting, balance problems, vision issues, cognitive impairment, and changes in behavior or personality.
Treatment for hydrocephalus typically involves surgically implanting a shunt system that diverts the excess CSF from the brain to another part of the body where it can be absorbed, such as the abdominal cavity. In some cases, endoscopic third ventriculostomy (ETV) might be an alternative treatment option, creating a new pathway for CSF flow within the brain. Regular follow-ups with neurosurgeons and other healthcare professionals are essential to monitor the condition and make any necessary adjustments to the treatment plan.
Fasciolidae is a family of parasitic flatworms, also known as trematodes or flukes. The two most well-known species in this family are Fasciola hepatica and Fasciola gigantica, which cause the disease fascioliasis in humans and animals. These flukes primarily infect the livers of their hosts, leading to symptoms such as abdominal pain, diarrhea, and liver damage. They have a complex life cycle involving multiple intermediate hosts, usually snails, before reaching their definitive host.
I believe there might be a misunderstanding in your question. "Dogs" is not a medical term or condition. It is the common name for a domesticated carnivore of the family Canidae, specifically the genus Canis, which includes wolves, foxes, and other extant and extinct species of mammals. Dogs are often kept as pets and companions, and they have been bred in a wide variety of forms and sizes for different purposes, such as hunting, herding, guarding, assisting police and military forces, and providing companionship and emotional support.
If you meant to ask about a specific medical condition or term related to dogs, please provide more context so I can give you an accurate answer.
The second trimester of pregnancy is the period between the completion of 12 weeks (the end of the first trimester) and 26 weeks (the beginning of the third trimester) of gestational age. It is often considered the most comfortable period for many pregnant women as the risk of miscarriage decreases significantly, and the symptoms experienced during the first trimester, such as nausea and fatigue, typically improve.
During this time, the uterus expands above the pubic bone, allowing more space for the growing fetus. The fetal development in the second trimester includes significant growth in size and weight, formation of all major organs, and the beginning of movement sensations that the mother can feel. Additionally, the fetus starts to hear, swallow and kick, and the skin is covered with a protective coating called vernix.
Prenatal care during this period typically includes regular prenatal appointments to monitor the mother's health and the baby's growth and development. These appointments may include measurements of the uterus, fetal heart rate monitoring, and screening tests for genetic disorders or other potential issues.
"Cat" is a common name that refers to various species of small carnivorous mammals that belong to the family Felidae. The domestic cat, also known as Felis catus or Felis silvestris catus, is a popular pet and companion animal. It is a subspecies of the wildcat, which is found in Europe, Africa, and Asia.
Domestic cats are often kept as pets because of their companionship, playful behavior, and ability to hunt vermin. They are also valued for their ability to provide emotional support and therapy to people. Cats are obligate carnivores, which means that they require a diet that consists mainly of meat to meet their nutritional needs.
Cats are known for their agility, sharp senses, and predatory instincts. They have retractable claws, which they use for hunting and self-defense. Cats also have a keen sense of smell, hearing, and vision, which allow them to detect prey and navigate their environment.
In medical terms, cats can be hosts to various parasites and diseases that can affect humans and other animals. Some common feline diseases include rabies, feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and toxoplasmosis. It is important for cat owners to keep their pets healthy and up-to-date on vaccinations and preventative treatments to protect both the cats and their human companions.
Cerebral arteries refer to the blood vessels that supply oxygenated blood to the brain. These arteries branch off from the internal carotid arteries and the vertebral arteries, which combine to form the basilar artery. The major cerebral arteries include:
1. Anterior cerebral artery (ACA): This artery supplies blood to the frontal lobes of the brain, including the motor and sensory cortices responsible for movement and sensation in the lower limbs.
2. Middle cerebral artery (MCA): The MCA is the largest of the cerebral arteries and supplies blood to the lateral surface of the brain, including the temporal, parietal, and frontal lobes. It is responsible for providing blood to areas involved in motor function, sensory perception, speech, memory, and vision.
3. Posterior cerebral artery (PCA): The PCA supplies blood to the occipital lobe, which is responsible for visual processing, as well as parts of the temporal and parietal lobes.
4. Anterior communicating artery (ACoA) and posterior communicating arteries (PComAs): These are small arteries that connect the major cerebral arteries, forming an important circulatory network called the Circle of Willis. The ACoA connects the two ACAs, while the PComAs connect the ICA with the PCA and the basilar artery.
These cerebral arteries play a crucial role in maintaining proper brain function by delivering oxygenated blood to various regions of the brain. Any damage or obstruction to these arteries can lead to serious neurological conditions, such as strokes or transient ischemic attacks (TIAs).
I believe there may be some confusion in your question. "Rabbits" is a common name used to refer to the Lagomorpha species, particularly members of the family Leporidae. They are small mammals known for their long ears, strong legs, and quick reproduction.
However, if you're referring to "rabbits" in a medical context, there is a term called "rabbit syndrome," which is a rare movement disorder characterized by repetitive, involuntary movements of the fingers, resembling those of a rabbit chewing. It is also known as "finger-chewing chorea." This condition is usually associated with certain medications, particularly antipsychotics, and typically resolves when the medication is stopped or adjusted.
Electron microscopy (EM) is a type of microscopy that uses a beam of electrons to create an image of the sample being examined, resulting in much higher magnification and resolution than light microscopy. There are several types of electron microscopy, including transmission electron microscopy (TEM), scanning electron microscopy (SEM), and reflection electron microscopy (REM).
In TEM, a beam of electrons is transmitted through a thin slice of the sample, and the electrons that pass through the sample are focused to form an image. This technique can provide detailed information about the internal structure of cells, viruses, and other biological specimens, as well as the composition and structure of materials at the atomic level.
In SEM, a beam of electrons is scanned across the surface of the sample, and the electrons that are scattered back from the surface are detected to create an image. This technique can provide information about the topography and composition of surfaces, as well as the structure of materials at the microscopic level.
REM is a variation of SEM in which the beam of electrons is reflected off the surface of the sample, rather than scattered back from it. This technique can provide information about the surface chemistry and composition of materials.
Electron microscopy has a wide range of applications in biology, medicine, and materials science, including the study of cellular structure and function, disease diagnosis, and the development of new materials and technologies.
The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:
1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.
The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.
Cisterna magna
James Purdon Martin
Dandy-Walker malformation
José Raúl Capablanca
Arne Torkildsen
Gesell Developmental Schedules
Median aperture
Subarachnoid cisterns
Cerebellar hypoplasia
Miodrag Radulovacki
Suboccipital puncture
Posterior atlantooccipital membrane
Human brain
3C syndrome
Chudley-Mccullough syndrome
Index of anatomy articles
Aperture (disambiguation)
List of MeSH codes (A08)
Sensenbrenner syndrome
Niemann-Pick disease
Colpocephaly
Fourth ventricle
List of regions in the human brain
Lympha
Via Giulia
Beecheria
Saint Roch
Pozzuoli
List of sister cities in the United States
Roman Catholic Diocese of Ruvo
Cisterna magna - Wikipedia
Cisterna Magna | Harvard Catalyst Profiles | Harvard Catalyst
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury | Scientific...
Mega cisterna magna associated with recurrent catatonia: a case report. | Read by QxMD
Dandy-Walker Malformation Imaging: Practice Essentials, Radiography, Computed Tomography
Port-wine nevi-mega cisterna magna-hydrocephalus syndrome - Global Genes
Bassett Collection Large Image - Lane Medical Library, Stanford University Medical Center
Systematic review and meta-analysis of isolated posterior fossa malformations on prenatal ultrasound imaging (part 1):...
Dandy-Walker Malformation Imaging: Practice Essentials, Radiography, Computed Tomography
The influence of cisternal and ventricular lavage on cerebral vasospasm in patients suffering from subarachnoid hemorrhage:...
King, Robert | Profiles RNS
IndexCat
Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical...
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Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming...
Contralateral far-lateral approach for clipping of a ruptured vertebral artery-posterior inferior cerebellar artery aneurysm in...
Refinement Database | Animal Welfare Institute
Refinement Database | Animal Welfare Institute
A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats | Protocol
JCI - Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
Angelman syndrome phenotype associated with mutations inMECP2, a gene encoding a methyl CpG binding protein | Journal of...
Temporal fossa arachnoid cyst presenting with bilateral subdural hematoma following trauma: Two case reports - Amrita Vishwa...
Passage Bio Reports First Quarter 2022 Financial Results and Provides Recent Business Highlights | BioSpace
Flashcards - Anatomy Final
NIMH » Macrophage Infection by HIV: Implications for Pathogenesis and Cure: Day One
The supracerebellar-transtentorial approach to posteromedial temporal lesions in children with refractory epilepsy in: Journal...
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The cervical lymph node contributes to peripheral inflammation related to Parkinson's disease | Lund University Publications
Brain
Plus it
Posterior fossa4
- Classically, posterior fossa cystic malformations have been divided into Dandy-Walker malformation, Dandy-Walker variant, mega cisterna magna, and posterior fossa arachnoid cyst. (medscape.com)
- Mega cisterna magna (see the image below) consists of an enlarged posterior fossa secondary to an enlarged cisterna magna, with a normal cerebellar vermis and fourth ventricle. (medscape.com)
- A rare developmental defect during embryogenesis syndrome characterized by a glabellar capillary malformation congenital communicating hydrocephalus and posterior fossa brain abnormalities including Dandy-Walker malformation cerebellar vermis agenesis and mega cisterna magna. (globalgenes.org)
- The posterior fossa anomalies analyzed were Dandy-Walker malformation (DWM), mega cisterna magna (MCM), Blake's pouch cyst (BPC) and vermian hypoplasia (VH). (nih.gov)
Spinal Cord2
- Stereotaxic Surgical Approach to Microinject the Caudal Brainstem and Upper Cervical Spinal Cord via the Cisterna Magna in Mice. (harvard.edu)
- To these ends, a fluorescent CSF tracer is injected either into the cisterna magna or the spinal cord parenchyma of rats and its pattern of redistribution, into or out of the cord, is analyzed. (hamiltoncompany.com)
Vectors1
- A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna. (umassmed.edu)
Cerebellomedullary4
- The cisterna magna (posterior cerebellomedullary cistern, or cerebellomedullary cistern) is the largest of the subarachnoid cisterns. (wikipedia.org)
- The Terminologia Anatomica classifies the terms cisterna magna and posterior cerebellomedullary cistern as synonyms. (wikipedia.org)
- The 42th edition of Gray's Anatomy (2020) and 12th edition of Last's Anatomy (2011) recognise the cisterna magna and cerebellomedullary cistern as synonyms, and do not describe a separate lateral cerebellomedullary cistern. (wikipedia.org)
- According to the 8th edition of the Clinical Oriented Anatomy (2018), the cerebellomedullary cistern is subdivided into the posterior cerebellomedullary cistern (cisterna magna), and the lateral cerebellomedullary cistern. (wikipedia.org)
Fourth ventricle2
- This sagittal T1-weighted MRI shows a large retrocerebellar cerebrospinal fluid collection and a normal fourth ventricle and vermis in a patient with mega cisterna magna in Dandy-Walker malformation. (medscape.com)
- Under this term are included a group of conditions that share in common one sonographic findings: the impression that the fourth ventricle communicates with the cisterna magna. (isuog.org)
Cerebellum1
- 1. Review of the fetal cerebellum and cisterna magna is a routine part of the screening ultrasound at 16 to 20 weeks. (radiology.world)
Interpeduncular1
- A) Non-contrast CT scan of the coronal section of brain shows diffuse large-volume hyperattenuation throughout the subarachnoid spaces in the quadrigeminal cisterns, interpeduncular cistern, prepontine cistern and cisterna magna with sparing of the vertex. (bmj.com)
Injection3
- Intra-cisterna magna injection, flow cytometric sorting and electrochemiluminescence immunoassays were applied to investigate the lymphatic drainage of α-syn from the CNS. (lu.se)
- Ayer introduced the concept of a cisterna magna injection to obtain samples of cerebrospinal fluid in 1920 (6) , and cisterna magna injections of lipiodol were used by the two French physicians Sicard and Forestier in 1923 (6) . (ajnr.org)
- The gene therapy product candidate, PBKR03, utilizes an AAVhu68 viral vector to deliver a functional GALC enzyme gene that codes for galactosylceramidase (GAL-C). The vector will be delivered directly to the cerebrospinal fluid by a single injection to the cisterna magna (ICM injection), with the goal of increasing levels of the GALC enzyme in both the central nervous system (CNS) and the peripheral nervous system (PNS). (marketresearch.com)
Cerebrospinal1
- 2022. Chronic collection of cerebrospinal fluid from rhesus macaques (Macaca mulatta) with cisterna magna ports: Update on refinements. (awionline.org)
Mega3
- Mega cisterna magna associated with recurrent catatonia: a case report. (qxmd.com)
- Dandy-Walker malformation, variant, and mega cisterna magna are currently believed to represent a continuum of developmental anomalies on a spectrum that has been termed the Dandy-Walker complex. (medscape.com)
- Newly diagnosed with Port-wine nevi-mega cisterna magna-hydrocephalus syndrome? (globalgenes.org)
Ultrasound1
- Specifically, we administered small (~1 kDa) and large (~155 kDa) molecule agents into the cisterna magna of rats and then applied low, diagnostic-intensity focused ultrasound in a scanning protocol throughout the brain. (stanford.edu)
MeSH1
- Cisterna Magna" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Publication1
- This graph shows the total number of publications written about "Cisterna Magna" by people in Harvard Catalyst Profiles by year, and whether "Cisterna Magna" was a major or minor topic of these publication. (harvard.edu)
Written2
- Below are the most recent publications written about "Cisterna Magna" by people in Profiles. (harvard.edu)
- This is a "connection" page, showing publications Robert King has written about Cisterna Magna. (umassmed.edu)
Delivery1
- Intrathecal Morphine Delivery at Cisterna Magna to Control Refractory Cancer-Related Pain: A Prospective Cohort Study. (harvard.edu)
Mega cisterna5
- Classically, posterior fossa cystic malformations have been divided into Dandy-Walker malformation, Dandy-Walker variant, mega cisterna magna, and posterior fossa arachnoid cyst. (medscape.com)
- Dandy-Walker malformation, variant, and mega cisterna magna are currently believed to represent a continuum of developmental anomalies on a spectrum that has been termed the Dandy-Walker complex. (medscape.com)
- Mega cisterna magna (see the image below) consists of an enlarged posterior fossa secondary to an enlarged cisterna magna, with a normal cerebellar vermis and fourth ventricle. (medscape.com)
- This sagittal T1-weighted MRI shows a large retrocerebellar cerebrospinal fluid collection and a normal fourth ventricle and vermis in a patient with mega cisterna magna in Dandy-Walker malformation. (medscape.com)
- Those features are characteristic of three related birth defects: Dandy-Walker malformation, cerebellar vermis hypoplasia and mega-cisterna magna. (spectrumnews.org)
Cerebellomedullary cistern5
- The cisterna magna (posterior cerebellomedullary cistern, or cerebellomedullary cistern) is the largest of the subarachnoid cisterns. (wikipedia.org)
- The Terminologia Anatomica classifies the terms cisterna magna and posterior cerebellomedullary cistern as synonyms. (wikipedia.org)
- The 42th edition of Gray's Anatomy (2020) and 12th edition of Last's Anatomy (2011) recognise the cisterna magna and cerebellomedullary cistern as synonyms, and do not describe a separate lateral cerebellomedullary cistern. (wikipedia.org)
- According to the 8th edition of the Clinical Oriented Anatomy (2018), the cerebellomedullary cistern is subdivided into the posterior cerebellomedullary cistern (cisterna magna), and the lateral cerebellomedullary cistern. (wikipedia.org)
- The tela chorioidea (11) forms the posterior part of the roof of the fourth ventricle and borders a large opening inferiorly, the foramen of Magendie, which forms the communication between the ventricle and the cerebellomedullary cistern (cisterna magna). (stanford.edu)
Fetal1
- The fetal cisterna magna. (loinc.org)
Posterior2
- The cisterna magna contains the two vertebral arteries, the origins of the two posterior inferior cerebellar arteries, the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (XII), and choroid plexus. (wikipedia.org)
- The cisterna magna may be tapped with a needle inserted superior to the posterior arch of atlas. (wikipedia.org)
Subarachnoid space1
- The cisterna magna is one of three principal openings in the subarachnoid space between the arachnoid and pia mater layers of the meninges surrounding the brain. (absoluteastronomy.com)
Ventricle1
- The fourth ventricle connects with the third ventricle through the cerebral aqueduct, with the cisterna magna through the foramen of Magendie and with the cerebellopontine angles through the lateral recesses. (neurosurgicalatlas.com)
Dural2
- 18. Cisterna magna meningiomas without dural attachment: Report of two cases. (nih.gov)
- Altough early reports, based on injections of India ink into the cisterna magna of the rat, suggested that the dural pathway accounts for only a minority of the drainage. (madridge.org)
Technique1
- A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna. (umassmed.edu)
Mice3
- Quantum dot 655 was injected into the CSF of the cisterna magna in seven mice and visualized by in vivo hyperspectral imaging at time points 20 and 40 min, 1, 2, and 6 h after injection. (biomedcentral.com)
- Here, we investigate the lymphatic drainage of CSF in mice using QD fluorescent nanoparticles injected into the cisterna magna and visualized by hyperspectral imaging in vivo . (biomedcentral.com)
- In seven mice, using a 25 μL syringe (Hamilton Co., NV, USA) with 33 g needle (20° beveled point, Hamilton Co., NV, USA) mounted on a stereotaxic arm, 3 μL of QD solution was manually injected over 1 min into the CSF of the cisterna magna. (biomedcentral.com)
Region1
- The cysts in the region of the cisterna magna show peripheral enhancement. (ajnr.org)
Type1
- in wild type and inherited diseases animal models (small and large animal models) by using different administration routes: oral, intravenous, intraperitoneal, Intra CSF (intraventricular, lumbar, intra cisterna magna) subcutaneous and local administration. (tigem.it)