Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Chemistry, Clinical: The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Clinical Chemistry Tests: Laboratory tests demonstrating the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Chemistry, Analytic: The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)Combinatorial Chemistry Techniques: A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.Blood Chemical Analysis: An examination of chemicals in the blood.Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Nobel PrizeMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Chemistry Techniques, Synthetic: Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs.Green Chemistry Technology: Pollution prevention through the design of effective chemical products that have low or no toxicity and use of chemical processes that reduce or eliminate the use and generation of hazardous substances.Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.Chemistry Techniques, Analytical: Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.Chemistry, Physical: The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.Evolution, Chemical: Chemical and physical transformation of the biogenic elements from their nucleosynthesis in stars to their incorporation and subsequent modification in planetary bodies and terrestrial biochemistry. It includes the mechanism of incorporation of biogenic elements into complex molecules and molecular systems, leading up to the origin of life.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Azides: Organic or inorganic compounds that contain the -N3 group.Biochemistry: The study of the composition, chemical structures, and chemical reactions of living things.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Cosmic Dust: Finely divided solid matter with particle sizes smaller than a micrometeorite, thus with diameters much smaller than a millimeter, moving in interplanetary space. (NASA Thesaurus, 1994)Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Extraterrestrial Environment: The environment outside the earth or its atmosphere. The environment may refer to a closed cabin (such as a space shuttle or space station) or to space itself, the moon, or other planets.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Biogenesis: The origin of life. It includes studies of the potential basis for life in organic compounds but excludes studies of the development of altered forms of life through mutation and natural selection, which is BIOLOGICAL EVOLUTION.Atmosphere: The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed)Organic Chemistry Processes: The reactions, changes in structure and composition, the properties of the reactions of carbon compounds, and the associated energy changes.Organic Chemicals: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Astronomy: The science concerned with celestial bodies and the observation and interpretation of the radiation received in the vicinity of the earth from the component parts of the universe (McGraw Hill Dictionary of Scientific and Technical Terms, 5th ed)Quantum Theory: The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Molecular Conformation: The characteristic three-dimensional shape of a molecule.Photoelectron Spectroscopy: The study of the energy of electrons ejected from matter by the photoelectric effect, i.e., as a direct result of absorption of energy from electromagnetic radiation. As the energies of the electrons are characteristic of a specific element, the measurement of the energy of these electrons is a technique used to determine the chemical composition of surfaces.Copper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.Adsorption: The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.History, 19th Century: Time period from 1801 through 1900 of the common era.Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Radiochemistry: The study of the chemical and physical phenomena of radioactive substances.Drug Discovery: The process of finding chemicals for potential therapeutic use.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Enzymes: Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.Gases: The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Coordination Complexes: Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Exobiology: The interdisciplinary science that studies evolutionary biology, including the origin and evolution of the major elements required for life, their processing in the interstellar medium and in protostellar systems. This field also includes the study of chemical evolution and the subsequent interactions between evolving biota and planetary evolution as well as the field of biology that deals with the study of extraterrestrial life.Photochemical Processes: Chemical reactions effected by light.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.History, 18th Century: Time period from 1701 through 1800 of the common era.Kinetics: The rate dynamics in chemical or physical systems.Autoanalysis: Method of analyzing chemicals using automation.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Sulfhydryl Compounds: Compounds containing the -SH radical.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Solar System: The group of celestial bodies, including the EARTH, orbiting around and gravitationally bound by the sun. It includes eight planets, one minor planet, and 34 natural satellites, more than 1,000 observed comets, and thousands of lesser bodies known as MINOR PLANETS (asteroids) and METEOROIDS. (From Academic American Encyclopedia, 1983)Hydrocarbons, Cyclic: Organic compounds composed exclusively of carbon and hydrogen forming a closed ring that may be either alicyclic or aromatic.Small Molecule Libraries: Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.Hematologic Tests: Tests used in the analysis of the hemic system.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)Fullerenes: A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Silanes: Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)History, 20th Century: Time period from 1901 through 2000 of the common era.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Ecotoxicology: The study of ENVIRONMENTAL POLLUTION and the toxic effects of ENVIRONMENTAL POLLUTANTS on the ECOSYSTEM. The term was coined by Truhaut in 1969.Dendrimers: Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Chemical Processes: The reactions and interactions of atoms and molecules, the changes in their structure and composition, and associated energy changes.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Microscopy, Scanning Tunneling: A type of scanning probe microscopy in which a very sharp conducting needle is swept just a few angstroms above the surface of a sample. The tiny tunneling current that flows between the sample and the needle tip is measured, and from this are produced three-dimensional topographs. Due to the poor electron conductivity of most biological samples, thin metal coatings are deposited on the sample.Electrons: Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Metal Nanoparticles: Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.PhotochemistryFluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Electrochemistry: The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.Particle Size: Relating to the size of solids.Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Elements: Substances that comprise all matter. Each element is made up of atoms that are identical in number of electrons and protons and in nuclear charge, but may differ in mass or number of neutrons.Molecular Probes: A group of atoms or molecules attached to other molecules or cellular structures and used in studying the properties of these molecules and structures. Radioactive DNA or RNA sequences are used in MOLECULAR GENETICS to detect the presence of a complementary sequence by NUCLEIC ACID HYBRIDIZATION.Biomimetics: An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Spectrum Analysis: The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Cyclooctanes: A group of compounds with an 8-carbon ring. They may be saturated or unsaturated.Wettability: The quality or state of being wettable or the degree to which something can be wet. This is also the ability of any solid surface to be wetted when in contact with a liquid whose surface tension is reduced so that the liquid spreads over the surface of the solid.Meteoroids: Any solid objects moving in interplanetary space that are smaller than a planet or asteroid but larger than a molecule. Meteorites are any meteoroid that has fallen to a planetary surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Agrochemicals: Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.Volcanic Eruptions: The ash, dust, gases, and lava released by volcanic explosion. The gases are volatile matter composed principally of about 90% water vapor, and carbon dioxide, sulfur dioxide, hydrogen, carbon monoxide, and nitrogen. The ash or dust is pyroclastic ejecta and lava is molten extrusive material consisting mainly of magnesium silicate. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Ions: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Physicochemical Phenomena: The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.Nanomedicine: The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).Laboratories: Facilities equipped to carry out investigative procedures.Cycloaddition Reaction: Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.Cross-Linking Reagents: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.Materials Testing: The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.Physics: The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Environmental Pollution: Contamination of the air, bodies of water, or land with substances that are harmful to human health and the environment.History, 21st Century: Time period from 2001 through 2100 of the common era.Clinical Laboratory Techniques: Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.Solid-Phase Synthesis Techniques: Techniques used to synthesize chemicals using molecular substrates that are bound to a solid surface. Typically a series of reactions are conducted on the bound substrate that results in either the covalent attachment of specific moieties or the modification of existing function groups. These techniques offer an advantage to those involving solution reactions in that the substrate compound does not have to be isolated and purified between the reaction steps.Hydrocarbons, FluorinatedBenzene DerivativesChromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Glass: Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Laboratories, Hospital: Hospital facilities equipped to carry out investigative procedures.Lightning: An abrupt high-current electric discharge that occurs in the ATMOSPHERE and that has a path length ranging from hundreds of feet to tens of miles. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Silicon Dioxide: Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.Halogens: A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.Evolution, Planetary: Creation and development of bodies within solar systems, includes study of early planetary geology.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Oligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Aldehydes: Organic compounds containing a carbonyl group in the form -CHO.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Blood Urea Nitrogen: The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Chemistry, Inorganic: A field of chemistry which pertains to chemical compounds or ions that do not contain the element carbon (with the exception of carbon dioxide and compounds containing a carbonate radical, e.g., calcium carbonate).Acid Rain: Acidic water usually pH 2.5 to 4.5, which poisons the ecosystem and adversely affects plants, fishes, and mammals. It is caused by industrial pollutants, mainly sulfur oxides and nitrogen oxides, emitted into the atmosphere and returning to earth in the form of acidic rain water.Nucleic Acids: High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.Catalytic Domain: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.Spectrum Analysis, Raman: Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Nucleic Acid Probes: Nucleic acid which complements a specific mRNA or DNA molecule, or fragment thereof; used for hybridization studies in order to identify microorganisms and for genetic studies.IminesNitrogen Oxides: Inorganic oxides that contain nitrogen.Groundwater: Liquid water present beneath the surface of the earth.Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.Saturn: The sixth planet in order from the sun. It is one of the five outer planets of the solar system. Its twelve natural satellites include Phoebe and Titan.Microscopy, Atomic Force: A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Bromine: A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Anions: Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.Microfluidic Analytical Techniques: Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.Free Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.Interdisciplinary Studies: Programs of study which span the traditional boundaries of academic scholarship.Ferric Compounds: Inorganic or organic compounds containing trivalent iron.Earth (Planet): Planet that is the third in order from the sun. It is one of the four inner or terrestrial planets of the SOLAR SYSTEM.Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)Eagles: Large members of the FALCONIFORMES order of birds, family Accipitridae, most especially the genera Aquila, Haliaeetus, Harpia, and Circaetus. They are characterized by their powerful talons, which carry long, curved, pointed claws and by their opposable hindtoe.Microfluidics: The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.KetonesCations: Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Bilirubin: A bile pigment that is a degradation product of HEME.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.Biochemical Phenomena: The chemical processes, enzymatic activities, and pathways of living things and related temporal, dimensional, qualitative, and quantitative concepts.Seawater: The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.Macrocyclic Compounds: Cyclic compounds with a ring size of approximately 1-4 dozen atoms.Natural Science Disciplines: The sciences dealing with processes observable in nature.Isotope Labeling: Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Lanthanoid Series Elements: Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).Halogenation: Covalent attachment of HALOGENS to other compounds.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Polystyrenes: Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.HydrocarbonsAlpha Particles: Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.Organophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Transition Elements: Elements with partially filled d orbitals. They constitute groups 3-12 of the periodic table of elements.Biocatalysis: The facilitation of biochemical reactions with the aid of naturally occurring catalysts such as ENZYMES.Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.Alkylation: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.Graphite: An allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation.
ChemistryAbstracts: Atomically resolved studies of the chemistry and bonding at silicon surfaces. Surface chemistry of silicon ... Advances in the chemistry of dipyrrins and their complexes. Abstracts: Bonding and organic and inorganic reactivity of metal- ... Abstracts: A green chemistry approach to asymmetric catalysis: Solvent-free and highly concentrated reactions. Advances in the ... Aromaticity as a cornerstone of heterocyclic chemistry. Abstracts: Alternative roles for metal ions in enzyme catalysis and the ...
ChemistryEllagitannin chemistry. Abstracts: Research at the interface between chemistry and virology: development of a molecular ... Nanostructured oxides in chemistry: characterization and properties. Abstracts: Progress in 1,2,3,4-tetrazine chemistry. ... Surface chemistry and tribology of mems. Abstracts: Reactions of hydrosilanes with transition-metal complexes: formation of ... Abstracts: Polyoxoanion chemistry moves toward the future: from solids and solutions to surfaces. Photo- and electrochromism of ...
Chemistry... is the science that shapes the world we will live in tomorrow. ... Study Chemistry at the University of Reading and you will benefit from our £4.5-million, state-of-the-art Chemical Analysis ... Chemistry is the science that has the most direct and dramatic impact on our lives. Chemists design, synthesise, analyse and ... Central to modern chemistry is the quest to make new molecules as efficiently and conveniently as possible, with minimum impact ...
Cosmic Chemistry... What happened after the Big Bang? This comic strip explains the interactions that lead to the creation of ... Hand out copies of the Cosmic Chemistry comic strip.. *Have students focus on the final fact: Each new generation of stars ...
Derivative (chemistry) - WikipediaIn chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction. ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Derivative_(chemistry)&oldid=779855519" ...
Chemistry... Authored by Jodi Lamm You don't want to read this book. I'm warning you. This isn't a heartwarming, boy-meets-girl, ...
Nature Reviews ChemistryComments and Highlights in all disciplines within pure and applied chemistry ... Nature Reviews Chemistry is an online-only journal publishing Reviews, Perspectives, ... Chemistry challenges to enable a sustainable bioeconomy A bioeconomy - that is, an economy in which fuels, chemicals and other ... The medicinal chemistry of ferrocene and its derivatives The unique properties of ferrocene-containing compounds make them ...
MVGS Chemistry PrimerThe series will focus on topics in a general chemistry high school course to enable the students to get a jump start on their ... Laourdakis will be hosting a chemistry primer for incoming sophomores at each of the campuses. This will consist of three ... Incoming sophomores are strongly encouraged to participate in the MVGS Chemistry Primer with Mr. Laoradakis. For those who ... https://www.khanacademy.org/science/chemistry/chemical-bonds/types-chemical-bonds/v/ionic-covalent-and-metallic-bonds ...
Chemistry | Science NewsIn the Sept. 30 SN: Smog's health woes, secrets of the bat brain, slug slime inspires surgical glue, wild beer, Neandertal tar recipes, the sun's recent flare-ups and more. ...
Chemistry - Terra SigillataChemistry. Terra Sigillata. Category archives for Chemistry. Are generic drugs inferior to the corresponding brand names?. ...
UK Chemistry OlympiadA UK chemistry competition for post-16 Chemistry students ... UK Chemistry Olympiad. A UK chemistry competition for post-16 ... based on real-world chemistry problems that often stimulate much debate, raising awareness of what chemistry is all about ... The UK Chemistry Olympiad is an extremely challenging competition, open to all schools in the UK. ... Schools located outside the UK that wish to participate in the UK Chemistry Olympiad are able to participate in Round one, ...
Organic Chemistry Frontiers... high impact journal for cutting-edge researches from all disciplines of organic chemistry ... supramolecular chemistry, theoretical chemistry, and other disciplines where involve knowledge in organic chemistry. ... Organic Chemistry Frontiers publishes high quality research from across organic chemistry. Emphases are placed on studies that ... Chemistry frontiers. Chemistry frontiers are concise, peer-reviewed, forward looking articles published upon invitation from ...
Celebrating National Chemistry Week17, 2016 /PRNewswire/ -- Celebrating National Chemistry Week. Chemours highlights the periodic table as the cornerstone of ... "At Chemours, we are proud to be a chemistry company and delighted to express that pride during National Chemistry Week with ... Chemours is featuring this iconic symbol of chemistry in these videos to showcase its commitment to chemistry-based innovation ... Celebrating National Chemistry Week Chemours highlights the periodic table as the cornerstone of product innovation and ...
Chemistry... Students and Faculty take the Chemistry Road Show to Hahnville High School On Friday, May 13th, 2016 students in the ... Chemistry students present research. September 14, 2017 at 8:47 am. Four chemistry students recently presented their research ... Leah Garber, 2010 chemistry graduate, earned the LSU Polymer Chemistry Award. Ms. Garber is currently developing polymeric ... Concentrations available in professional chemistry, pre-med and pre-dental, pre-pharmacy and biochemistry.. • Undergraduate ...
ChemistryTeacher resources and professional development across the curriculum. ...
Latest Research | Nature ChemistryRead the latest Research articles from Nature Chemistry ... Interest in surface-mediated chemistry has led to the design of ... Dynamic covalent chemistry enables formation of antimicrobial peptide quaternary assemblies in a completely abiotic manner ... Now, the dynamic covalent chemistry of hydrazide- and aldehyde-containing peptides has now been shown to enable the formation ... Catalysis involving high-valent metals is an important facet of modern chemistry, but tools for catalyst development in this ...
Physical Chemistry | SpringerNobel Prize Chemistry 2016. See what Laureates published with Springer! Enjoy free access to all articles until Dec 12 ...
Food Chemistry Award... This award was discontinued in 2008.. The RSC Award for Food Chemistry, sponsored by Unilever R&D ... Colworth, was awarded for studies, including analytical, that provide new insights into the science of food chemistry. ...
Contact | Nature Reviews ChemistryOnline access to Nature Reviews Chemistry will be available for library and institutions to purchase through an NPG site ...
Inorganic Chemistry | SpringerDiscover Springers category Chemistry and the exciting subcategories. Enjoy free shipping worldwide or read your title as an ... Nobel Prize Chemistry 2016. See what Laureates published with Springer! Enjoy free access to all articles until Dec 12 ... Applications of Radiation Chemistry in the Fields of Industry, Biotechnology and Environment. Venturi, M. (et al.) (Eds.) (2017 ... Recent Development in Clusters of Rare Earths and Actinides: Chemistry and Materials. Zheng, Z. (Ed.) (2017) ...
Wiley: Water ChemistryYou are now subscribed to our email alert for Accounting Technology.. ...
Gridlocks- Learn ChemistryComplete grids for a variety of chemistry topics, such as units of volume, state symbols and many more. ... A Future in Chemistry The Mole magazine Assessment for Learning Chemistry: What is stuff made of? ... If you would like to receive the answers to any of the PDF puzzles, please email firstname.lastname@example.org. ... Complete grids for a variety of chemistry topics, such as units of volume, state symbols and many more. ...
Chemistry - FacultyChemistry Home. Faculty Slides. Chemistry - California. Chemistry - Florida. Department Contacts. Department of Chemistry ... Ph.D., Chemistry, The Scripps Research Institute, 2004. M.A., Bioorganic Chemistry, University of Virginia, 2000. B.S., ... Frontiers in Chemistry Symposium. Named Lectures. Recruiting. CA Faculty. Baran, Phil Blackmond, Donna Boger, Dale Bollong, ... Chemistry, University of Virginia, 1999. Awards & Professional Activities. Editorial Advisory Board, Current Organic Chemistry ...
Chemistry | Faculty History ProjectThe Faculty History Project documents faculty members who have been associated with the University of Michigan since 1837, and the history of the University's schools and colleges. This project is part of a larger effort to prepare resources for the University's bicentennial in 2017. Find out more.. ...
Copper-free click chemistry: Copper-free click chemistry is a bioorthogonal reaction first developed by Carolyn Bertozzi as an activated variant of an azide alkyne Huisgen cycloaddition, based on the work by Fokin and Sharpless et al. Unlike the CuAAC, Cu-free click chemistry has been modified to be bioorthogonal by eliminating a cytotoxic copper catalyst, allowing reaction to proceed quickly and without live cell toxicity.Clinical Biochemistry: Clinical Biochemistry is a peer-reviewed scientific journal covering the analytical and clinical investigation of laboratory tests in humans used for diagnosis, molecular biology and genetics, prognosis, treatment and therapy, and monitoring of disease ; the discipline of clinical biochemistry. It is the official journal of the Canadian Society of Clinical Chemists.Outline of organic chemistry: The following outline is provided as an overview of and topical guide to organic chemistry:Serum-separating tube: Serum-separating tubes, also known as serum separator tubes or SSTs, are used in medical clinical chemistry tests requiring blood serum.C4H7N3O3Process analytical chemistry: Process Analytical Chemistry (PAC), is similar to Process Analytical Technology (PAT) (for example used for the pharmaceutical industry) has its origins as a specialized form of analytical chemistry used for process manufacturing. Process analytical chemistry is the application of analytical chemistry with specialized techniques, algorithms, and sampling equipment for solving problems related to chemical processes.Noncovalent solid-phase organic synthesis: Noncovalent solid-phase organic synthesis or NC-SPOS is a form of Solid-phase synthesis whereby the organic substrate is bonded to the solid phase not by a covalent bond but by other chemical interactions. This bond may consist of an induced dipole interaction between a hydrophobic matrix and a hydrophobic anchor.Alkyne: In organic chemistry, an alkyne is an unsaturated hydrocarbon containing at least one carbon—carbon triple bond between two carbon atoms.Alkyne.ACS Medicinal Chemistry Letters: ACS Medicinal Chemistry Letters is a peer-reviewed academic journal in the field of medicinal chemistry. Founded in 2009, this online journal is published monthly by the American Chemical Society.Rosalyn Sussman YalowConvergent synthesis: In chemistry a convergent synthesis is a strategy that aims to improve the efficiency of multistep synthesis, most often in organic synthesis. In this type of synthesis several individual pieces of a complex molecule are synthesised in stage one and then in stage two these pieces are combined to form the final product Organic Synthesis, 3th Ed.Eco-friendly dentistry: Eco-friendly dentistry"What is Eco-friendly Dentistry is defined by various dentists and dental organizations and primarily consists of general dentistry, oral surgery and other specialty dental services featuring green practices to reduce impact on the eco-system, the environment and patient treatment practices.Supramolecular polymers: thumbnail|250px|An example of a quadruple [[hydrogen bonds reported by Meijer and coworkers in Angew. Chem.Food physical chemistry: Food physical chemistry is considered to be a branch of Food chemistryJohn M. de Man.Primordial soup: "Primordial soup" is a term introduced by the Soviet biologist Alexander Oparin. In 1924, he proposed a theory of the origin of life on Earth through the transformation, during the gradual chemical evolution of molecules that contain carbon in the primordial soup.Surface modification: Surface modification is the act of modifying the surface of a material by bringing physical, chemical or biological characteristics different from the ones originally found on the surface of a material.Stilbene photocyclization: Stilbene photocyclization is the coupling of two aromatic carbons in stilbenes upon ultraviolet irradiation. The reaction can be used to form polycyclic aromatic hydrocarbons and heteroaromatics.Azide: Azide is the anion with the formula N3Frank Dickens (biochemist): Frank Dickens FRS (15 December 1899 - 15 June 1986) was a biochemist, best known for his work at the Courtauld Institute of Biochemistry with Edward Charles Dodds on the pentose phosphate pathway which generates NADPH.Peter N.Reaction coordinateTable of standard reduction potentials for half-reactions important in biochemistry: The values below are standard reduction potentials for half-reactions measured at 25°C, 1 atmosphere and a pH of 7 in aqueous solution.Acid catalysis: In acid catalysis and base catalysis a chemical reaction is catalyzed by an acid or a base. The acid is the proton donor and the base is the proton acceptor.Interstellar cloud: Interstellar cloud is the generic name given to an accumulation of gas, plasma, and dust in our and other galaxies. Put differently, an interstellar cloud is a denser-than-average region of the interstellar medium.Shiva crater: The Shiva Crater is a geologic structure, which is hypothesized by Sankar ChatterjeeChatterjee, S. (1997) Multiple impacts at the KT boundary and the death of the dinosaurs.Sharpless asymmetric dihydroxylation: Sharpless asymmetric dihydroxylation (also called the Sharpless bishydroxylation) is the chemical reaction of an alkene with osmium tetroxide in the presence of a chiral quinine ligand to form a vicinal diol.Primordial sandwich: The concept of the primordial sandwich was proposed by the chemist Günter Wächtershäuser to describe the possible origins of the first cell membranes, and, therefore, the first cell.Stratosphere: The stratosphere is the second major layer of Earth's atmosphere, just above the troposphere, and below the mesosphere. It is stratified in temperature, with warmer layers higher up and cooler layers farther down.PrinomastatPolymer blend: A polymer blend or polymer mixture is a member of a class of materials analogous to metal alloys, in which at least two polymers are blended together to create a new material with different physical properties. Section 3.Submillimetre astronomy: Submillimetre astronomy or submillimeter astronomy (see spelling differences) is the branch of observational astronomy that is conducted at submillimetre wavelengths (i.e.Trapped ion quantum computer: A trapped ion quantum computer is one proposed approach to a large-scale quantum computer. Ions, or charged atomic particles, can be confined and suspended in free space using electromagnetic fields.Outline of water: The following outline is provided as an overview of and topical guide to water:Ultraviolet photoelectron spectroscopy: Ultraviolet photoelectron spectroscopy (UPS) refers to the measurement of kinetic energy spectra of photoelectrons emitted by molecules which have absorbed ultraviolet photons, in order to determine molecular orbital energies in the valence region.Copper toxicityAdsorptionNewington Green Unitarian ChurchNatron: Natron is a naturally occurring mixture of sodium carbonate decahydrate (Na2CO3·10H2O, a kind of soda ash) and about 17% sodium bicarbonate (also called baking soda, NaHCO3) along with small quantities of sodium chloride and sodium sulfate. Natron is white to colourless when pure, varying to gray or yellow with impurities.History of nanotechnology: The history of nanotechnology traces the development of the concepts and experimental work falling under the broad category of nanotechnology. Although nanotechnology is a relatively recent development in scientific research, the development of its central concepts happened over a longer period of time.Radiochemistry: Radiochemistry is the chemistry of radioactive materials, where radioactive isotopes of elements are used to study the properties and chemical reactions of non-radioactive isotopes (often within radiochemistry the absence of radioactivity leads to a substance being described as being inactive as the isotopes are stable). Much of radiochemistry deals with the use of radioactivity to study ordinary chemical reactions.Fragment-based lead discovery: Fragment-based lead discovery (FBLD) also known as fragment-based drug discovery (FBDD) is a method used for finding lead compounds as part of the drug discovery process. It is based on identifying small chemical fragments, which may bind only weakly to the biological target, and then growing them or combining them to produce a lead with a higher affinity.Spin–lattice relaxation in the rotating frame: Spin–lattice relaxation in the rotating frame is the mechanism by which Mxy, the transverse component of the magnetization vector, exponentially decays towards its equilibrium value of zero, under the influence of a radio frequency (RF) field in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). It is characterized by the spin–lattice relaxation time constant in the rotating frame, T1ρ.Enzyme Commission number: The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze.Volumetric heat capacity: Volumetric heat capacity (VHC), also termed volume-specific heat capacity, describes the ability of a given volume of a substance to store internal energy while undergoing a given temperature change, but without undergoing a phase transition. It is different from specific heat capacity in that the VHC is a 'per unit volume' measure of the relationship between thermal energy and temperature of a material, while the specific heat is a 'per unit mass' measure (or occasionally per molar quantity of the material).China Biologic Products, Inc.Coordination complex: In chemistry, a coordination complex or metal complex consists of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents. Many metal-containing compounds, especially those of transition metals, are coordination complexes.Analytical quality control: Analytical quality control, commonly shortened to AQC refers to all those processes and procedures designed to ensure that the results of laboratory analysis are consistent, comparable, accurate and within specified limits of precision.analytical quality control (AQC) program to ensure the highest level of confidence in reported data Constituents submitted to the analytical laboratory must be accurately described to avoid faulty interpretations, approximations, or incorrect results.Metallocene: A metallocene is a compound typically consisting of two cyclopentadienyl anions (Cp, which is C5H5−) bound to a metal center (M) in the oxidation state II, with the resulting general formula (C5H5)2M. Closely related to the metallocenes are the metallocene derivatives, e.Surface modification of biomaterials with proteins: Biomaterials are materials that are used in contact with biological systems. Biocompatibility and applicability of surface modification with current uses of metallic, polymeric and ceramic biomaterials allow alteration of properties to enhance performance in a biological environment while retaining bulk properties of the desired device.Ethyl groupCarbon chauvinism: Carbon chauvinism is a neologism meant to disparage the assumption that the chemical processes of hypothetical extraterrestrial life must be constructed primarily from carbon (organic compounds) because carbon's chemical and thermodynamic properties render it far superior to all other elements.Collision/reaction cell: A collision/reaction cell is a device used in inductively coupled plasma mass spectrometry to remove interfering ions through ion/neutral reactions.Nanoparticle: Nanoparticles are particles between 1 and 100 nanometers in size. In nanotechnology, a particle is defined as a small object that behaves as a whole unit with respect to its transport and properties.Enlightenment Intensive: An Enlightenment Intensive is a group retreat designed to enable a spiritual enlightenment experience within a relatively short time. Devised by Americans Charles (1929–2007) and Ava Berner in the 1960s,http://www.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".Kodak DCS 300 series: The Kodak DCS 300 series comprised two cameras, the DCS 315 and DCS 330. They were professional-level digital SLR cameras built by Eastman Kodak's Kodak Professional Imaging Solutions division.Atomic mass: right |thumb|200px|Stylized [[lithium-7 atom: 3 protons, 4 neutrons, & 3 electrons (total electrons are ~1/4300th of the mass of the nucleus). It has a mass of 7.Perchloromethyl mercaptanNencki Institute of Experimental Biology: The Nencki Institute of Experimental Biology is a Polish scientific research organization and a part of Polish Academy of Sciences headquartered in Warsaw, Poland. Founded in 1918, it is a leading institution in the country in the field of neurobiology, molecular biology and biochemistry.NebulaCyclopentadieneDNA-encoded chemical library: DNA-encoded chemical libraries (DEL) is a technology for the synthesis and screening of collections of small molecule compounds of unprecedented size. DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology.Organic base: An organic base is an organic compound which acts as a base. Organic bases are usually, but not always, proton acceptors.Metals in medicine: Metals in medicine are used in organic systems for diagnostic and treatment purposes. Inorganic elements are also essential for organic life as cofactors in enzymes called Metalloproteins.Metallofullerene: In chemistry, a metallofullerene is a molecule composed of a metal atom trapped inside a fullerene cage.Ligand (biochemistry): In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. In protein-ligand binding, the ligand is usually a signal-triggering molecule binding to a site on a target protein.Electrophilic substitution of unsaturated silanes: Electrophilic substitution of unsaturated silanes involves attack of an electrophile on an allyl- or vinylsilane. An allyl or vinyl group is incorporated at the electrophilic center after loss of the silyl group.Molecular Foundry: thumbnail|200px|The Molecular Foundry building in Berkeley, CaliforniaPhase problem: In physics the phase problem is the name given to the problem of loss of information concerning the phase that can occur when making a physical measurement. The name itself comes from the field of x-ray crystallography, where the phase problem has to be solved for the determination of a structure from diffraction data.The Flash ChroniclesColes PhillipsEcotoxicology: Ecotoxicology is the study of the effects of toxic chemicals on biological organisms, especially at the population, community, ecosystem level. Ecotoxicology is a multidisciplinary field, which integrates toxicology and ecology.Ferrocene-containing dendrimersCarbon–carbon bond: A carbon–carbon bond is a covalent bond between two carbon atoms. The most common form is the single bond: a bond composed of two electrons, one from each of the two atoms.Alkaliphile: Alkaliphiles are a class of extremophilic microbes capable of survival in alkaline (pH roughly 8.5-11) environments, growing optimally around a pH of 10.Palladium(II) chlorideSEA Native Peptide LigationMcLafferty rearrangement: The McLafferty rearrangement is a reaction observed in mass spectrometry. It is sometimes found that a molecule containing a keto-group undergoes β-cleavage, with the gain of the γ-hydrogen atom.Fluorescent glucose biosensor: Fluorescent glucose biosensors are devices that measure the concentration of glucose in diabetic patients by means of sensitive protein that relays the concentration by means of fluorescence, an alternative to amperometric sension of glucose. No device has yet entered the medical market,No fluorescent biosensor has yet entered the medical market, however, in the market for research tools several fluorescent biosensors are present, such as a kit using [Vibrio fischeri] but, due to the prevalence of diabetes, it is the prime drive in the construction of fluorescent biosensors.Silicene: Silicene is a two-dimensional allotrope of silicon, with a hexagonal honeycomb structure similar to that of graphene.Valence electron: In chemistry, a valence electron is an electron that is associated with an atom, and that can participate in the formation of a chemical bond; in a single covalent bond, both atoms in the bond contribute one valence electron in order to form a shared pair. The presence of valence electrons can determine the element's chemical properties and whether it may bond with other elements: For a main group element, a valence electron can only be in the outermost electron shell.Standard enthalpy of formation: The standard enthalpy of formation or standard heat of formation of a compound is the change of enthalpy during the formation of 1 mole of the compound from its constituent elements, with all substances in their standard states at 1 atmosphere (1 atm or 101.3 kPa).Polyvalent DNA gold nanoparticles: Polyvalent DNA gold nanoparticles are colloidal gold whose surface is modified with thiol capped synthetic DNA sequences. They were co-discovered by Chad Mirkin et al.Lattice protein: Lattice proteins are highly simplified computer models of proteins which are used to investigate protein folding.Fluorescent tag: In molecular biology and biotechnology, a fluorescent tag, also known as a label or probe, is a molecule that is attached chemically to aid in the labeling and detection of a biomolecule such as a protein, antibody, or amino acid. Generally, fluorescent tagging, or labeling, uses a reactive derivative of a fluorescent molecule known as a fluorophore.DNA condensation: DNA condensation refers to the process of compacting DNA molecules in vitro or in vivo. Mechanistic details of DNA packing are essential for its functioning in the process of gene regulation in living systems.Arteriovenous oxygen difference: The arteriovenous oxygen difference, or a-vO2 diff, is the difference in the oxygen content of the blood between the arterial blood and the venous blood. It is an indication of how much oxygen is removed from the blood in capillaries as the blood circulates in the body.DNA binding site: DNA binding sites are a type of binding site found in DNA where other molecules may bind. DNA binding sites are distinct from other binding sites in that (1) they are part of a DNA sequence (e.Bipolar electrochemistry: Bipolar electrochemistry is a phenomenon in electrochemistry based on the polarization of conducting objects in electric fields. Indeed, this polarization generates a potential difference between the two extremities of the substrate that is equal to the electric field value multiplied by the size of the object.
(1/7085) An investigation into the binding of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one to DNA in vitro.
After metabolic activation the carcinogen 15,16-dihydro-11-[3H]methylcyclopenta[a]phenanthren-17-one binds to DNA in vitro, and this binding is prevented by 7,8-benzoflavone. Radioactivity cannot be removed from the DNA with organic solvents or by chromatography on Sephadex G-50, even after heat denaturation of the DNA. Enzymatic hydrolysis yields radioactive fractions, which elute from a column of Sephadex LH-20 immediately after the natural nucleosides. At least two species of reactive metabolites are involved in this bending, those with a half-life of a few hr and others with greater stability. After extraction from the aqueous incubation mixture, they could be detected in discrete polar fractions from separations of the complex metabolite mixture by high-pressure liquid chromatography. Their ability to bind to DNA decreased with time at ambient temperature, and they were rapidly deactivated by acid. 7,8-Benzolflavone acted by suppressing the formation of polar metabolites derived from enzymatic oxidation of the aromatic double bonds. The inhibitor had no effect on the enzymes hydroxylating saturated carbon; hence it is unlikely that metabolism of the methyl group is important in conversion of this carcinogen to its proximate form, although the presence of the 11-methyl group is essential for carcinogenic activity in this series. (+info)
(2/7085) The interaction of rhodium(II) carboxylates with enzymes.
The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irreversibly inhibited. Those enzymes without essential sulfhydryl groups were not affected. In each case, the rate of inactivation closely paralleled the observed toxicity and antitumor activity of rhodium(II) carboxylates; that is, rhodium(II) propionate greater than rhodium(II) acetate greater than rhodium(II) methoxyacetate. In addition, those enzymes that have been demonstrated to be most sensitive to established sulfhydryl inhibitors, such as glyceraldehyde-3-phosphate dehydrogenase, were also most sensitive to rhodium(II) carboxylate inactivation. Proton nuclear magnetic resonance measurements made during the titration of rhodium(II) acetate with cysteine showed that breakdown of the carboxylate cage occurred as a result of reaction with this sulfhydryl-containing amino acid. (+info)
(3/7085) Glycopeptides from the surgace of human neuroblastoma cells.
Glycopeptides suggesting a complex oligosaccharide composition are present on the surface of cells from human neuroblastoma tumors and several cell lines derived from the tumors. The glycopeptides, labeled with radioactive L-fucose, were removed from the cell surface with trypsin, digested with Pronase, and examined by chromatography on Sephadex G-50. Human skin fibroblasts, brain cells, and a fibroblast line derived from neuroblastoma tumor tissue show less complex glycopeptides. Although some differences exist between the cell lines and the primary tumor cells, the similarities between these human tumors and animal tumors examined previously are striking. (+info)
(4/7085) The isolation and partial characterization of the serum lipoproteins and apolipoproteins of the rainbow trout.
1. VLD (very-low-density), LD (low-density) and HD (high-density) lipoproteins were isolated from the serum of trout (Salmo gairdneri Richardson). 2. Each lipoprotein class resembled that of the human in immunological reactivity, electrophoretic behaviour and appearance in the electron microscope. Trout LD lipoprotein, however, was of greater density than human LD lipoprotein. 3. The trout lipoproteins have lipid compositions which are similar to those of the corresponding human components, except for their high contents of long-chain unsaturated fatty acids. 4. HD and LD lipoproteins were immunologically non-identical, whereas LD lipoproteins possessed antigenic determinants in common with VLD lipoproteins. 5. VLD and HD lipoproteins each contained at least seven different apoproteins, whereas LD liprotein was composed largely of a single apoprotein which resembled human apolipoprotein B. 6. At least one, and possibly three, apoprotein of trout HD lipoprotein showed features which resemble human apoprotein A-1.7. The broad similarity between the trout and human lipoprotein systems suggests that both arose from common ancestral genes early in evolutionary history. (+info)
(5/7085) Studies of the binding of different iron donors to human serum transferrin and isolation of iron-binding fragments from the N- and C-terminal regions of the protein.
1. Trypsin digestion of human serum transferrin partially saturated with iron(III)-nitrilotriacetate at pH 5.5 or pH 8.5 produces a carbohydrate-containing iron-binding fragment of mol.wt. 43000. 2. When iron(III) citrate, FeCl3, iron (III) ascorabate and (NH4)2SO4,FeSO4 are used as iron donors to saturate the protein partially, at pH8.5, proteolytic digestion yields a fragment of mol.wt. 36000 that lacks carbohydrate. 3. The two fragments differ in their antigenic structures, amino acid compositions and peptide 'maps'. 4. The fragment with mol.wt. 36000 was assigned to the N-terminal region of the protein and the other to the C-terminal region. 5. The distribution of iron in human serum transferrin partially saturated with various iron donors was examined by electrophoresis in urea/polyacrylamide gels and the two possible monoferric forms were unequivocally identified. 6. The site designated A on human serum transferrin [Harris (1977) Biochemistry 16, 560--564] was assigned to the C-terminal region of the protein and the B site to the N-terminal region. 7. The distribution of iron on transferrin in human plasma was determined. (+info)
(6/7085) Carbon 13 NMR study of nonenzymatic reactions of pyridoxal 5'-phosphate with selected amino acids and of related reactions.
Carbon 13 nuclear magnetic resonance spectroscopy has been used to monitor the nonenzymatic reactions of pyridoxal 5'-phosphate with glycine, alanine, valine, serine, and with several other model compounds. Isotopically enriched amino acids were employed so that low concentrations could be utilized while still allowing relatively rapid acquisition of spectral data. The results for alanine and serine are particularly noteworthy in that alanine is deaminated to pyruvate and pyruvate is aminated to alanine, but contrary to the enzymatic reactions of various serine dehydratases wherein serine is converted to pyruvate, the nonenzymatic reaction utilizing serine results in hydroxypruvate rather than pyruvate formation. In the reverse reaction, hydroxypyruvate is aminated to serine but very inefficiently relative to the amination of pyruvate to alanine. The experimental results have been formulated into a proposed reaction mechanism for deamination of amino acids by pyridoxal-P. (+info)
(7/7085) Herpetic keratitis. Proctor Lecture.
Although much needs to be learned about the serious clinical problem of herpes infection of the cornea, we have come a long way. We now have effective topical antiviral drugs. We have animal models which, with a high degree of reliability, clearly predict the effect to be expected clinically in man, as well as the toxicity. We have systemically active drugs and the potential of getting highly active, potent, completely selective drugs, with the possibility that perhaps the source of viral reinfection can be eradicated. The biology of recurrent herpes and stromal disease is gradually being understood, and this understanding may result in new and better therapy of this devastating clinical disease. (+info)
(8/7085) Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.
The crystal structure of the FMN-binding domain of human NADPH-cytochrome P450 reductase (P450R-FMN), a key component in the cytochrome P450 monooxygenase system, has been determined to 1.93 A resolution and shown to be very similar both to the global fold in solution (Barsukov I et al., 1997, J Biomol NMR 10:63-75) and to the corresponding domain in the 2.6 A crystal structure of intact rat P450R (Wang M et al., 1997, Proc Nat Acad Sci USA 94:8411-8416). The crystal structure of P450R-FMN reported here confirms the overall similarity of its alpha-beta-alpha architecture to that of the bacterial flavodoxins, but reveals differences in the position, number, and length of the helices relative to the central beta-sheet. The marked similarity between P450R-FMN and flavodoxins in the interactions between the FMN and the protein, indicate a striking evolutionary conservation of the FMN binding site. The P450R-FMN molecule has an unusual surface charge distribution, leading to a very strong dipole, which may be involved in docking cytochrome P450 into place for electron transfer near the FMN. Several acidic residues near the FMN are identified by mutagenesis experiments to be important for electron transfer to P4502D6 and to cytochrome c, a clear indication of the part of the molecular surface that is likely to be involved in substrate binding. Somewhat different parts are found to be involved in binding cytochrome P450 and cytochrome c. (+info)
- Oct. 17, 2016 /PRNewswire/ -- The Chemours Company (Chemours) (NYSE: CC), a global chemistry company with leading market positions in titanium technologies, fluoroproducts and chemical solutions, today released a playful series of short videos- The Periodic Table: Something to Sing About -to celebrate our favorite science during National Chemistry Week. (prnewswire.com)
Nature Reviews Chemistry
- Online access to Nature Reviews Chemistry will be available for library and institutions to purchase through an NPG site license. (nature.com)
- Chemistry Students and Faculty take the Chemistry Road Show to Hahnville High School On Friday, May 13th, 2016 students in the Chemistry club and chemistry faculty spent the day at Hahnville High School in Boutte, Louisiana. (nicholls.edu)
- Scott will continue his chemistry studies in the PhD program at Oklahoma State in fall of 2016. (nicholls.edu)
- Bijeta Prasai, 2012 chemistry graduate, earned the 2016 Dissertation Year Fellowship from LSU. (nicholls.edu)
- Central to modern chemistry is the quest to make new molecules as efficiently and conveniently as possible, with minimum impact on the environment. (reading.ac.uk)
- Concentrations available in professional chemistry , pre-med and pre-dental , pre-pharmacy and biochemistry . (nicholls.edu)
- an opportunity to develop and showcase some of the skills required for studying Chemistry at university and beyond. (rsc.org)
- Chemours is featuring this iconic symbol of chemistry in these videos to showcase its commitment to chemistry-based innovation. (prnewswire.com)
- Chemistry is the science that shapes the world we will live in tomorrow. (reading.ac.uk)
- Chemistry is the science that has the most direct and dramatic impact on our lives. (reading.ac.uk)
- The RSC Award for Food Chemistry, sponsored by Unilever R&D Colworth, was awarded for studies, including analytical, that provide new insights into the science of food chemistry. (rsc.org)
- Study Chemistry at the University of Reading and you will benefit from our £4.5-million, state-of-the-art Chemical Analysis Facility, as well as unrivalled support from the team regarded as the UK's top Chemistry department for employability (Guardian University Guide 2014). (reading.ac.uk)
- In chemistry , a derivative is a compound that is derived from a similar compound by a chemical reaction . (wikipedia.org)
- This UK competition is an opportunity to stretch and challenge post-16 Chemistry students by testing their chemical knowledge. (rsc.org)
- Chemours is a global leader in titanium technologies, fluoroproducts and chemical solutions, providing its customers with solutions in a wide range of industries with market-defining products, application expertise and chemistry-based innovations. (prnewswire.com)
- Nicholls chemistry is accredited by the American Chemical Society , which opens the door for careers in industry, teaching and graduate schools. (nicholls.edu)
- Organic Chemistry Frontiers publishes high quality research from across organic chemistry. (rsc.org)
- All original research work published in Organic Chemistry Frontiers is in one Research article format. (rsc.org)
- Four chemistry students recently presented their research results at the 11th Annual Research Week held on the Nicholls campus from February 29th - March 3rd. (nicholls.edu)
- The series will focus on topics in a general chemistry high school course to enable the students to get a jump start on their AP/dual enrolled materials. (google.com)
- Courtney Beamer, Michael Kramer, Shane Swan and Cyrus PIcou each presented posters on a variety topics, ranging from environmental chemistry to molecular modeling. (nicholls.edu)
- Gold, silver and bronze certificates are awarded to high-scoring students, while the top-performing students from participating UK schools are chosen by the Royal Society of Chemistry Olympiad Selection Committee to progress to Round two. (rsc.org)
- Typically, the four highest-performing students are selected to represent the UK in international chemistry competitions. (rsc.org)
- All students should be predicted an A or A* in A-level Chemistry (or equivalent). (rsc.org)
- 11th grade students in Ms. Grunblatt's Chemistry I classes learned about some of the exciting things that chemists do. (nicholls.edu)
- Leah Garber, 2010 chemistry graduate, earned the LSU Polymer Chemistry Award. (nicholls.edu)
- Nicholls State University is an ideal place to learn chemistry with its outstanding faculty and modern facilities. (nicholls.edu)
- Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. (rsc.org)
- Come see Nicholls Chemistry alum Dr. Bijeta Prasai at our department seminar in Beauregard 104. (nicholls.edu)
- Other chemistry majors will be present to help you learn all the ins and outs of the department. (nicholls.edu)
- Incoming sophomores are strongly encouraged to participate in the MVGS Chemistry Primer with Mr. Laoradakis. (google.com)
- Schools located outside the UK that wish to participate in the UK Chemistry Olympiad are able to participate in Round one, however they are not eligible to proceed to Round two. (rsc.org)
- CC ) helps create a colorful, capable and cleaner world through the power of chemistry. (prnewswire.com)
- Nicholls Chemistry grads change the world! (nicholls.edu)
- a recent chemistry graduate, is now working at Dow as a quality control specialist. (nicholls.edu)