Central Nervous System Sensitization

Central Nervous System

Central Nervous System Diseases

Fatty alcohol

Stimulant

Acrylonitrile

Hydrazine

Allodynia

5-HT2B receptor

Habituation

Fibromyalgia

Neuroplasticity

Pain in babies

Opioid-induced hyperalgesia

Acoustic shock

Kindling (sedative-hypnotic withdrawal)

Complex regional pain syndrome

Tension headache

Central pain syndrome

Davida Teller

1-Butanol

Ethyl acetate

Nociplastic pain

Triptan

AZD9272

Marcello Brunelli

Chronic fatigue syndrome

Itch

Liisa Ahtee

TRPV1

Learning

Peripheral mononeuropathy

Metabotropic glutamate receptor 5

Chronic11

• Central sensitization is a nervous system irregularity that may contribute to chronic pain. (medicalnewstoday.com)
• Many women with chronic pelvic pain also have a condition called central sensitization of the nervous system. (bcwomens.ca)
• Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? (meresearch.org.uk)
• When the pain is widespread, again, these are individuals that we don't really have a great care pathway or a care model for because then they have these sort of chronic overlapping pain conditions, this nociplastic pain or central sensitization, and there are not many providers that feel quite comfortable managing those individuals. (medscape.com)
• Multiple sclerosis is a chronic inflammatory disease of the central nervous system which leads to the formation of focal confluent lesions of primary demyelination in the white and gray matter and to diffuse damage and neurodegeneration in the entire brain ( 1 ). (frontiersin.org)
• Given the potential for central sensitization and/or neuropathic pain in chronic osteoarthritis pain, use of drugs which target the central nervous system may be beneficial. (vin.com)
• Central sensitization is a condition that is associated with the maintenance of chronic pain. (progressivepain.com)
• Overtime, chronic pain and misread signals can physically change the way the central nervous system responds to pain. (progressivepain.com)
• The experts at Progressive Pain Management can help control your chronic pain and reduce symptoms caused by central sensitization. (progressivepain.com)
• Chronic opioid therapy is more strongly associated with central sensitization in sickle cell disease than clinical p. (onescdvoice.com)
• Centrally mediated chronic myalgia is a chronic, continuous muscle disorder, originating in the central nervous system, which generates symptoms at the periphery of muscle tissues 4 . (bvsalud.org)

Neuropathic pain1

• We also evidence that CIII neurons make use of atypical depolarizing chloride currents to encode cold, and that overexpression of ncc69 -a fly homologue of NKCC1 -results in phenotypes consistent with neuropathic sensitization, including behavioral sensitization and neuronal hyperexcitability, making Drosophila CIII neurons a candidate system for future studies of the basic mechanisms underlying neuropathic pain. (elifesciences.org)

Peripheral6

• These findings suggest an important role of peripheral CGRP in visceral nociception and organ cross-sensitization and support the evaluation of CGRP as a therapeutic target for visceral pain in patients with IBS and/or BPS/IC. (aspetjournals.org)
• The initial injury can occur in either the peripheral or central nervous system. (spine-health.com)
• The topic of central and peripheral sensitization was also addressed. (esteve.com)
• This is the central amplification of a peripheral pain signal. (progressivepain.com)
• The peripheral and central nervous systems work together to help the body determine how the body reacts to a sensation. (progressivepain.com)
• Nociceptive pathways, inflammatory mediators and sensitization of both central and peripheral pathways have been shown to play important roles in pancreatic pain (76). (pancreapedia.org)

Irritation2

• Dazomet exposure is also tied to severe skin irritation, skin sensitization, itchy eyes, and blurred vision. (naturalpedia.com)
• Dermal exposure has produced severe skin irritation and sensitization. (cdc.gov)

Dysfunction4

• The pathophysiology of fibromyalgia (FM) involves many mechanisms including central nervous system sensitization theory, autonomic nervous system (ANS) dysfunction, and recently small fiber neuropathy. (iasp-pain.org)
• It is caused by a dysfunction that affects the central nervous system, such as multiple sclerosis, Parkinson's disease, or spinal cord injuries. (progressivepain.com)
• It is thought by neurologists and pain specialists to be caused by dysfunction in the central nervous system as wells as the muscles and connective tissue, and rheumatologists' class it as central sensitization. (magnetamerica.com)
• Typical indications include leukemia, myelodysplasia, aplastic anemia, solid tumors, congenital or acquired/medication-induced platelet dysfunction, central nervous system trauma, and patients undergoing extracorporeal membrane oxygenation or cardiopulmonary bypass may also need platelet transfusion. (medscape.com)

Autonomic1

• Meanwhile, the autonomic nervous system stimulates the suprarenal medulla to secrete hormones such as epinephrine into the bloodstream. (medscape.com)

Responds to pain1

• Central sensitization alters how the body responds to pain and may lead to people continually experiencing pain even after an injury has healed. (medicalnewstoday.com)

Mechanisms1

• These observations are consistent with the likelihood of a neuropathic component of OA that elicits ongoing, NSAID-resistant pain and central sensitization that is mediated, in part, by descending modulatory mechanisms. (nih.gov)

Spinal cord3

• It is not licensed for use for pain in dogs but contributes to pain relief by reducing the development of sensitisation to pain in the central nervous system (e.g. brain and spinal cord). (vetspecialists.co.uk)
• Although the condition is diagnosed based on self-reported muscular pain, recent evidence points to the source of the pain as originating from the nervous system, via the process of central sensitization-the abnormal amplification of pain signals in the spinal cord. (amtamassage.org)
• When the spinal cord increases the pain signals, your central nervous system understands them as incredibly intense and painful. (progressivepain.com)

Nociceptive1

• nociceptive inputs from these MTrPs may be linked to central sensitization. (medscape.com)

Amplification1

• An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS). (bvsalud.org)

Depression3

• May cause central nervous system depression or effects. (nationaldiagnostics.com)
• Flash Point: deg C. Flammable liquid and cause central nervous system depression. (pdf4pro.com)
• The mononitrophenols were moderately toxic to animals, causing initial stimulation and subsequent depression of the respiratory and central nervous systems. (cdc.gov)

Respiratory1

• Dazomet may negatively affect muscle health, the respiratory tract, and the central nervous system. (naturalpedia.com)

Neurons2

• The two mainstreams of cells that build up the central nervous system are neurons and glia, the latter of which for quite a long time are supposed to act as the background of the former, supporting, nourishing and protecting the neurons [ 1 ]. (degruyter.com)
• CIII neurons function via a high-low threshold detection system, whereby high levels of CIII activation (and strong Ca 2+ transients) are associated with CT, and low levels of activation (and relatively modest Ca 2+ transients) with touch behaviors. (elifesciences.org)

Sensory1

• As a component of the human immune and inflammatory response system, pain is experienced when sensory signals are transmitted to the nervous system to cause a motor reaction toward harmful stimuli [ 2 ]. (hindawi.com)

Threshold1

• Probably the most controversial threshold is for the clinically stable patient with an intact vascular system and normal platelet function. (medscape.com)

Affects2

• carried in the bloodstream, affects the autonomous nervous system, which controls functions such as the heart rate, dilation of the pupils, and secretion of sweat and saliva. (fibromyalgia-associationuk.org)
• This, in turn, affects the excitability of the nervous system. (medscape.com)

Clinical2

• Pain at rest is the key factor of the clinical characteristics of this disorder and probably occurs due to the sensitization of the muscle nociceptors by algogenic substances released in the neurogenic inflammatory process 4 . (bvsalud.org)
• 3 Universidade de São Paulo, Faculdade de Filosofia Ciências in clinical parameters suggestive of central sensitization e Letras de Ribeirão Preto, Ribeirão Preto, SP, Brazil. (bvsalud.org)

Irritable2

• Irritable bowel syndrome (IBS) and bladder pain syndrome/interstitial cystitis (BPS/IC) are comorbid visceral pain disorders seen commonly in women with unknown etiology and limited treatment options and can involve visceral organ cross-sensitization. (aspetjournals.org)
• These conditions like fibromyalgia, irritable bowel, and headache have taught us about this third mechanism of pain, which is being called nociplastic pain and used to be called central sensitization, where the pain is really coming from the central nervous system rather than from the region of the body in which the person is experiencing pain. (medscape.com)

Body's2

• ANS) Part of the nervous system that involuntarily controls the body's internal environment, e.g. the muscle of the heart. (fibromyalgia-associationuk.org)
• Naturopathic medicine is a holistic system of healthcare that emphasizes the body's ability to heal itself and addresses the root causes of disease. (naturaltherapycenter.com)

Abnormal1

• In three rodent models, we employed a monoclonal anti-CGRP F(ab') 2 to investigate the hypothesis that visceral organ cross-sensitization is mediated by abnormal CGRP signaling. (aspetjournals.org)

Involve1

• Both conditions may involve central sensitization. (medicalnewstoday.com)

Inhalation1

• Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. (pdf4pro.com)

Phenomenon2

• Lack of sleep, in fact, could lead to a phenomenon called central nervous system sensitization. (jointhealthmagazine.com)
• Over time, exposure to significant pain can cause changes to the central nervous system that make the body become more sensitive to even slight touch-a phenomenon known as central sensitization. (spine-health.com)

Inflammatory1

• Treating Discogenic Pain by Reducing Dorsal Root Ganglion Cell Sensitization using the COX-2 Inhibitor Celecoxib - An in vitro Study with Inflammatory Cytokine Treated Annulus Fibrosus Cells. (aofoundation.org)

Mechanical1

• The administration of TNF- α and interleukins IL-1 β , IL-8, IL-12, IL-15, and IL-18 in rodents via intradermal route has been shown to produce a heightened and prolonged mechanical sensitization and hypernociception [ 5 ]. (hindawi.com)

Temporomandibular2

• A secondary goal of this pilot study was to see whether it was possible to measure improvement in localized areas of pain in conditions that result in widespread pain and central sensitization-conditions that include fibromyalgia, low back pain and temporomandibular disorder. (amtamassage.org)
• Objetivo: analisar parâmetros clínicos sugestivos de sensibilização central em mulheres com disfunção temporomandibular dolorosa crônica antes e após uma intervenção baseada em mindfulness . (bvsalud.org)

Brain1

• Background: Withdrawal is believed to play a central role in the brain disease model of addiction. (bvsalud.org)

Painful1

• May cause painful sensitization to light. (pdf4pro.com)

Headache1

• The mechanism of medication overuse headache is thought to include sensitization of the central nervous system similar to what occurs in migraine. (msdmanuals.com)

Body1

• The endocrine system-the other communication system in the body-is made up of endocrine glands that produce hormones, chemical substances released into the bloodstream to guide processes such as metabolism, growth, and sexual development. (medscape.com)

Patients2

• Not only are patients who suffer from central sensitization extremely sensitive to things that should hurt, but ordinary things like a simple touch or slight pressure can be excruciating. (progressivepain.com)
• Pain that typical patients may describe as a two on a numeric pain scale (1-10 level of pain) may feel like an 8 or a 9 for patients that have central sensitization. (progressivepain.com)

Immune2

• A type of protein produced by the immune system when it detects harmful antigens (bacteria, fungi, parasites & viruses). (fibromyalgia-associationuk.org)
• How does the concept of the "neuro-immune system" change things? (advanced-trainings.com)

Similar1

• Similar to central sensitization, central pain syndrome is heightened by light touch. (progressivepain.com)

Chemicals3

• The GHS is an acronym for The Globally Harmonized System of Classification and Labelling of Chemicals. (whatsinproducts.com)
• The GHS is a system for standardizing and harmonizing the classification and labelling of chemicals. (whatsinproducts.com)
• Chemicals are associated with codes that define their health, physical and environmental hazards.This universal hazard communication system was developed to ensure that employers, employees and consumers are provided with adequate, practical, reliable and comprehensible information on the hazards of chemicals, so that they can take effective preventive and protective measure for their own health and safety. (whatsinproducts.com)

Drug2

• With the advent of improved tools to examine the astrocytes, which have been believed to play a supportive role in the central nervous system (CNS) for years, their participation in the operation of the CNS and drug addiction was unveiled. (degruyter.com)
• A central tenet of controlling AMR is antibiotic drug stewardship, which seeks to limit inappropriate antibiotic drug usage by avoiding unnecessary prescribing, including discontinuing antibiotic therapy if it is not required. (cdc.gov)

Sensitive1

• How can we progress individuals with such sensitive nervous systems or crippling fear of movement? (ptproductsonline.com)

Fibromyalgia1

• Fibromyalgia is recognized as one of many central pain-related syndromes that are common in the general population. (medscape.com)

Condition1

• Central pain syndrome is a neurological condition. (progressivepain.com)

Contribute1

• Our findings suggest that central sensitization and neuropathic features contribute to NSAID-resistant ongoing OA joint pain. (nih.gov)