Cell and tissue based therapy. Medical search. Web

Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).

A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.

Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.

Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.

An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.

Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.

Spinal cord injuries (SCI) refer to damage to the spinal cord that results in a loss of function, such as mobility or feeling. This injury can be caused by direct trauma to the spine or by indirect damage resulting from disease or degeneration of surrounding bones, tissues, or blood vessels. The location and severity of the injury on the spinal cord will determine which parts of the body are affected and to what extent.

The effects of SCI can range from mild sensory changes to severe paralysis, including loss of motor function, autonomic dysfunction, and possible changes in sensation, strength, and reflexes below the level of injury. These injuries are typically classified as complete or incomplete, depending on whether there is any remaining function below the level of injury.

Immediate medical attention is crucial for spinal cord injuries to prevent further damage and improve the chances of recovery. Treatment usually involves immobilization of the spine, medications to reduce swelling and pressure, surgery to stabilize the spine, and rehabilitation to help regain lost function. Despite advances in treatment, SCI can have a significant impact on a person's quality of life and ability to perform daily activities.

The spinal cord is a major part of the nervous system, extending from the brainstem and continuing down to the lower back. It is a slender, tubular bundle of nerve fibers (axons) and support cells (glial cells) that carries signals between the brain and the rest of the body. The spinal cord primarily serves as a conduit for motor information, which travels from the brain to the muscles, and sensory information, which travels from the body to the brain. It also contains neurons that can independently process and respond to information within the spinal cord without direct input from the brain.

The spinal cord is protected by the bony vertebral column (spine) and is divided into 31 segments: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal. Each segment corresponds to a specific region of the body and gives rise to pairs of spinal nerves that exit through the intervertebral foramina at each level.

The spinal cord is responsible for several vital functions, including:

1. Reflexes: Simple reflex actions, such as the withdrawal reflex when touching a hot surface, are mediated by the spinal cord without involving the brain.
2. Muscle control: The spinal cord carries motor signals from the brain to the muscles, enabling voluntary movement and muscle tone regulation.
3. Sensory perception: The spinal cord transmits sensory information, such as touch, temperature, pain, and vibration, from the body to the brain for processing and awareness.
4. Autonomic functions: The sympathetic and parasympathetic divisions of the autonomic nervous system originate in the thoracolumbar and sacral regions of the spinal cord, respectively, controlling involuntary physiological responses like heart rate, blood pressure, digestion, and respiration.

Damage to the spinal cord can result in various degrees of paralysis or loss of sensation below the level of injury, depending on the severity and location of the damage.

Quadriplegia, also known as tetraplegia, is a medical condition characterized by paralysis affecting all four limbs and the trunk of the body. It results from damage to the cervical spinal cord, typically at levels C1-C8, which controls signals to the muscles in the arms, hands, trunk, legs, and pelvic organs. The extent of quadriplegia can vary widely, ranging from weakness to complete loss of movement and sensation below the level of injury. Other symptoms may include difficulty breathing, bowel and bladder dysfunction, and sexual dysfunction. The severity and prognosis depend on the location and extent of the spinal cord injury.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Paraplegia is a medical condition characterized by partial or complete loss of motor function and sensation in the lower extremities, typically affecting both legs. This results from damage to the spinal cord, often due to trauma such as accidents, falls, or gunshot wounds, or from diseases like spina bifida, polio, or tumors. The specific area and extent of the injury on the spinal cord determine the severity and location of paralysis. Individuals with paraplegia may require assistive devices for mobility, such as wheelchairs, and may face various health challenges, including pressure sores, urinary tract infections, and chronic pain.

A pressure ulcer, also known as a pressure injury or bedsore, is defined by the National Pressure Injury Advisory Panel (NPIAP) as "localized damage to the skin and/or underlying soft tissue usually over a bony prominence or related to a medical or other device." The damage can be caused by intense and/or prolonged pressure or shear forces, or a combination of both. Pressure ulcers are staged based on their severity, ranging from an initial reddening of the skin (Stage 1) to full-thickness tissue loss that extends down to muscle and bone (Stage 4). Unstageable pressure ulcers are those in which the base of the wound is covered by yellow, tan, green or brown tissue and the extent of tissue damage is not visible. Suspected deep tissue injury (Suspected DTI) describes intact skin or non-blanchable redness of a localized area usually over a bony prominence due to pressure and/or shear. The area may be preceded by tissue that is painful, firm, mushy, boggy, warmer or cooler as compared to adjacent tissue.

Spinal cord diseases refer to a group of conditions that affect the spinal cord, which is a part of the central nervous system responsible for transmitting messages between the brain and the rest of the body. These diseases can cause damage to the spinal cord, leading to various symptoms such as muscle weakness, numbness, pain, bladder and bowel dysfunction, and difficulty with movement and coordination.

Spinal cord diseases can be congenital or acquired, and they can result from a variety of causes, including infections, injuries, tumors, degenerative conditions, autoimmune disorders, and genetic factors. Some examples of spinal cord diseases include multiple sclerosis, spina bifida, spinal cord injury, herniated discs, spinal stenosis, and motor neuron diseases such as amyotrophic lateral sclerosis (ALS).

The treatment for spinal cord diseases varies depending on the underlying cause and severity of the condition. Treatment options may include medication, physical therapy, surgery, and rehabilitation. In some cases, the damage to the spinal cord may be irreversible, leading to permanent disability or paralysis.

... the biophysical mechanisms underlying migration at the level of cells and tissues; biomimetic systems for cell-based assays; ... Samuel Sánchez Ordóñez Bacterial infections: antimicrobial therapies Dr. Eduart Torrents Integrative cell and tissue dynamics ... "Integrative cell and tissue dynamics". Institute for Bioengineering of Catalonia. Retrieved 2021-04-26. Institute for ... Bioengineering for Regenerative Therapies: Molecular dynamics at the interface of cells and biomaterials; ...

https://en.wikipedia.org/wiki/Institute_for_Bioengineering_of_Catalonia

Kabu S, Gao Y, Kwon BK, Labhasetwar V (December 2015). "Drug delivery, cell-based therapies, and tissue engineering approaches ... Types of cells being researched for use in SCI include embryonic stem cells, neural stem cells, mesenchymal stem cells, ... olfactory ensheathing cells, Schwann cells, activated macrophages, and induced pluripotent stem cells. Hundreds of stem cell ... "Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions". Stem Cells ...

https://en.wikipedia.org/wiki/Spinal_cord_injury

Retrieved June 13, 2022.{{cite web}}: CS1 maint: unfit URL (link) "Advancing Gene, Cell, & Tissue-Based Therapies". Alliance ... advocacy organization supporting the development of regenerative medicines including gene therapy and stem-cell therapy. ... In May 2015, Pfizer and a Bar-Ilan University laboratory announced a partnership based on the development of medical DNA ... The same month, the company acquired Bamboo Therapeutics for $645 million, expanding its gene therapy offerings. In September ...

https://en.wikipedia.org/wiki/Pfizer

Kabu, S.; Gao, Y.; Kwon, B.K.; Labhasetwar, V. (2015). "Drug delivery, cell-based therapies, and tissue engineering approaches ... Stem cells are cells that can differentiate to become different types of cells. The hope is that stem cells transplanted into ... Types of cells being researched for use in SCI include embryonic stem cells, neural stem cells, mesenchymal stem cells, ... "Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration". Stem Cells International. 2015: 1-24. doi:10.1155/2015/ ...

https://en.wikipedia.org/wiki/Spinal_cord_injury_research

... outside the cell they can damage tissue. Proponents suggest that its effects are tissue dependent, though the subject is still ... Ozone-based treatments can be associated with central nervous system toxicity, termed Ozone Induced Encephalopathy (OIE). OIE ... Ozone therapy, Autologous ozone blood therapy, Oxygen-ozone autologous blood therapy, Oxyon therapy, Hyperbaric ozone therapy: ... Proponents of the therapy falsely claim it is a recognized therapy there, but ozone therapy is not approved by the German ...

https://en.wikipedia.org/wiki/Ozone_therapy

"Cryopreservation and Cell Banking for Autologous Mesenchymal Stem Cell-Based Therapies". Cell & Tissue Transplantation & ... Cell banks often contain expansive amounts of base cell material that can be utilized for various projects. Cell banks can be ... and development cell banks Master cell bank Working cell bank End-of-production cell bank While research and development cell ... thus preserving the cell line, which is especially useful when the cell line has a limited number of cell divisions. Cells can ...

https://en.wikipedia.org/wiki/Cell_bank

These include blood and blood products, vaccines, allergenics, cell and tissue-based products, and gene therapy products. New ... cirmweb (June 4, 2012). "The surprising journey from a horse named Jim to stem cell therapies at UC Davis". The Stem Cellar. ... The districts are based roughly on the geographic divisions of the Federal court system. Each district comprises a main ... The most rigorous requirements apply to new molecular entities: drugs that are not based on existing medications. New drugs ...

https://en.wikipedia.org/wiki/Food_and_Drug_Administration

The company develops, produces and markets cell-based tools for life science, tissue engineering, drug discovery and cosmetics ... The company's research and development focus lies in the fields of cell immune therapy and adult stem cell therapy. 3H ... vectors for genetic modification and cell-based assays. "3H Biomedical AB". Archived from the original on 2011-10-07. Retrieved ... The company started out marketing and selling primary cells, and has since extended its portfolio with cell chips, RNA, DNA, ...

https://en.wikipedia.org/wiki/3H_Biomedical

"Microencapsulated stem cells for tissue repairing: implications in cell-based myocardial therapy". Regen Med. 4 (5): 733-45. ... An emerging approach to answer the problems related to ischemic tissue repair is through the use of stem cell-based therapy. ... research is the use of stem cells such as mesenchymal stem cells for long term cell microencapsulation and cell therapy ... xenogeneic cells). The use of autologous cells in microencapsulation therapy is limited by the availability of these cells and ...

https://en.wikipedia.org/wiki/Cell_encapsulation

Designed to be applied broadly, the original definition includes cell and stem cell therapies, gene therapy, tissue engineering ... an overview of their potential in cell-based therapy". Expert Opinion on Biological Therapy. 15 (9): 1293-306. doi:10.1517/ ... Examples include the injection of stem cells or progenitor cells obtained through directed differentiation (cell therapies); ... When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ ...

https://en.wikipedia.org/wiki/Regenerative_medicine

Topics covered include neural stem cells, neural tissue engineering, gene therapy, and minimally-invasive treatment of ... evidence-based case reports, and perspectives. The journal is abstracted and indexed in BIOSIS Previews, Chemical Abstracts, ... Neural Regeneration Research is a peer-reviewed scientific journal covering research on neuroregeneration and stem cells. ...

https://en.wikipedia.org/wiki/Neural_Regeneration_Research

TFF prevents division and destroys cancers cells with electric fields while sparing healthy tissue. Additionally, emerging ... Greater mechanistic understanding of TTFields may pave the way for new, more effective TTFields-based therapeutic combinations ... This division is uncontrolled in cancer cells. The TTFields electric charge prevents the cancer cell from dividing, thereby ... 2016). "An Overview of Alternating Electric Fields Therapy (NovoTTF Therapy) for the Treatment of Malignant Glioma". Current ...

https://en.wikipedia.org/wiki/Alternating_electric_field_therapy

"Growth in Sales of Products In Cell Therapy and Tissue Engineering". ebers Medical. "Scaling Up Cell Therapy Manufacturing". ... Of this alternative, animal-based form of cell therapy, the American Cancer Society say: "Available scientific evidence does ... Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are ... such as CAR T-cell therapies and allogeneic therapies. Cell and gene therapies require manufacturer and distributors alike to ...

https://en.wikipedia.org/wiki/Cell_therapy

... a One-Time Regenerative Tissue-Based Therapy for Pediatric Congenital Athymia" (Press release). Enzyvant. 8 October 2021. ... Kreins AY, Bonfanti P, Davies EG (2021). "Current and Future Therapeutic Approaches for Thymic Stromal Cell Defects". Frontiers ... Allogeneic processed thymus tissue, sold under the brand name Rethymic, is a thymus tissue medical therapy used for the ... "Enzyvant Receives FDA Approval for Rethymic (allogeneic processed thymus tissue-agdc), a One-Time Regenerative Tissue-Based ...

https://en.wikipedia.org/wiki/Allogeneic_processed_thymus_tissue

"Cardiac tissue engineering and regeneration using cell-based therapy". Stem Cells and Cloning: Advances and Applications. 8: 81 ... Cell line as well as cell type such as fibroblasts can largely impact tissue responses towards implanted foreign devices by ... "Scaffolds and cells for tissue regeneration: different scaffold pore sizes-different cell effects". Cytotechnology. 68 (3): 355 ... Furthermore, cells release reactive oxygen species and cytokines, which cause secondary damage to surrounding tissue. These ...

https://en.wikipedia.org/wiki/Tissue_engineering_of_heart_valves

... which allows the selective destruction of cancer cells without any damage to normal tissues. It is a light-based cancer therapy ... Based on the current hypothesis, cell death induced by PIT was caused by rapid expansion of local water upon the formation of ... "Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to ... Conventional photodynamic therapy (PDT) uses a non-specific photosensitizer which can be activated by a non-ionizing light to ...

https://en.wikipedia.org/wiki/Photoimmunotherapy

... cell transplantation has focused on various dopamine producing cells throughout the body. fetal ventral mesencephalic tissue ( ... pigment epithelium embryonic stem cells induced pluripotent stem cells mesenchymal stem cells The first cell-based therapy ... It includes two populations of cells; glomus (type I) cells and sustentacular (type II) cells. Glomus cells are derived from ... Cell-based therapies for Parkinson's disease include various investigational procedures which transplant specific populations ...

https://en.wikipedia.org/wiki/Cell-based_therapies_for_Parkinson's_disease

... and tissue engineering. He studies how to create safer and more effective medical and surgical therapy based on tissue ... Saltzman built scaffolds that could be seeded with cells to sculpt new replacement tissues. He also created drug-impregnated ... 1990) Books Drug Delivery: Engineering Principles for Drug Therapy, 2001, Published by Oxford University Press. Tissue ... "Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma". Proceedings of the National ...

https://en.wikipedia.org/wiki/W._Mark_Saltzman

... techniques for controlling the behavior of patient-derived cells to engineer artificial tissues and cell-based therapies. He is ... including gold nanoparticles and carbon-based nanomaterials. He has demonstrated the use of GelMA-based materials for tissue ... "Khademhosseini and Team Develop Tissue-Based Soft Robot". Retrieved 28 August 2023. "Ali Khademhosseini - Google Scholar ... "SAM-based cell transfer to photopatterned hydrogels for microengineering vascular-like structures". Biomaterials. 32 (30): 7479 ...

https://en.wikipedia.org/wiki/Ali_Khademhosseini

These data suggests that DPSCs in combination with EGF could be an effective stem cell-based therapy to bone tissue engineering ... EGF plays an enhancer role on the osteogenic differentiation of dental pulp stem cells (DPSCs) because it is capable of ... Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. ... Harris RC, Chung E, Coffey RJ (March 2003). "EGF receptor ligands". Experimental Cell Research. 284 (1): 2-13. doi:10.1016/ ...

https://en.wikipedia.org/wiki/Epidermal_growth_factor

These TReg cells are targets for therapies against autoimmune diseases, cancer, and transplanted tissue rejection. He has been ... Since 2015, Thomson Reuters (now Clarivate) has listed Shevach as among those most likely to win a Nobel Prize, based on his ... Shevach made significant contributions towards understanding the function of regulatory T cells (TReg cells) in mediating the ... He discovered a subset of CD4+ T cells that express the transcription factor FOXP3 and operate by a mechanism that is distinct ...

https://en.wikipedia.org/wiki/Ethan_M._Shevach

Hao, L; Lawrence, J; Chian, KS (2005). "Osteoblast cell adhesion on a laser modified zirconia based bioceramic". Journal of ... Chai, Chou; Leong, Kam W (2007). "Biomaterials Approach to Expand and Direct Differentiation of Stem Cells". Molecular Therapy ... Since the elastic modulus values of ceramic materials are generally higher than that of the surrounding bone tissue, the ... While cell culture tests show a good biocompatibility, the analysis of implants shows significant wear, related to a ...

https://en.wikipedia.org/wiki/Bioceramic

Placon Therapeutics is developing platinum-based cancer therapies. These include BTP-114, the first clinical candidate to use ... with the goal of targeting cancerous tissue and leaving healthy cells alone. Its proprietary drug candidates included BTP-114, ... He has made major contributions in a number of areas, including the development of platinum-based anticancer drugs such as the ... Rosenberg, B.; Van Camp, L.; Krigas, T. (1965). "Inhibition of Cell Division in Escherichia coli by Electrolysis Products from ...

https://en.wikipedia.org/wiki/Stephen_J._Lippard

More recently hyperthermia therapy uses microwaves to heat tissue to kill cancer cells. However, as detailed below, the ... In Europe, the use of the ISM band is covered by Short Range Device regulations issued by European Commission, based on ... the standards on which almost all wireless systems are based, use the ISM bands. Virtually all laptops, tablet computers, ...

https://en.wikipedia.org/wiki/ISM_radio_band

There are many different methods of gene delivery for various types of cells and tissues. Viral based vectors emerged in the ... Gene therapy utilizes gene delivery to deliver genetic material with the goal of treating a disease or condition in the cell. ... Viral vector based gene delivery uses a viral vector to deliver genetic material to the host cell. This is done by using a ... which forces the DNA to enter the cells through either cell pores or the damaged cell wall. Another simple methods involves ...

https://en.wikipedia.org/wiki/Gene_delivery

Unlike photodynamic therapy, photothermal therapy does not require oxygen to interact with the target cells or tissues. Current ... Wang Y, Meng HM, Song G, Li Z, Zhang XB (August 2020). "Conjugated-Polymer-Based Nanomaterials for Photothermal Therapy". ACS ... Huang X, El-Sayed IH, Qian W, El-Sayed MA (February 2006). "Cancer cell imaging and photothermal therapy in the near-infrared ... investigated the feasibility of using gold nanorods for both cancer cell imaging as well as photothermal therapy. The authors ...

https://en.wikipedia.org/wiki/Photothermal_therapy

GenCure focuses on the development of cell-based therapies, providing biomanufacturing capabilities for clinical research and ... BioBridge Global is a San Antonio-based nonprofit holding company that operates the South Texas Blood & Tissue Center, QualTex ... GenCure operates the Texas Cord Blood Bank, which collects and processes umbilical cord for banking, stem cell therapy, and ... During his tenure, tissue services were added and in 1994 the center was renamed the South Texas Blood and Tissue Center. ...

https://en.wikipedia.org/wiki/BioBridge_Global

The diagnosis is based on tissue examination, e.g. biopsy.[citation needed] Under the microscope, glassy cell carcinoma tumours ... Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and ... Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix. ... 2004). "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature". ...

https://en.wikipedia.org/wiki/Glassy_cell_carcinoma_of_the_cervix

Koshiol J, Lin SW (July 2012). "Can tissue-based immune markers be used for studying the natural history of cancer?". review. ... using large-scale population-based data (e.g., PIK3CA mutation in colorectal cancer to select patients for aspirin therapy). ... by means of molecular pathology or surrogate histopathology or immunohistochemistry analysis of diseased tissues and cells ... Cancer Biology & Therapy. 6 (7): 1143-7. doi:10.4161/cbt.6.7.4704. PMID 17630503. Slattery ML, Herrick J, Curtin K, Samowitz W ...

https://en.wikipedia.org/wiki/Molecular_pathological_epidemiology

... which uses CRISPR-Cas9 to kill cancer cells without harming normal tissues. 22 February - A study uses 'years of potential life ... Progress in biomarkers-based cancer screening is reported: researchers estimate risks for prostate cancer based on age, PSA and ... "Cellular rejuvenation therapy safely reverses signs of aging in mice". Salk Institute. 7 March 2022. Retrieved 9 March 2022. ... The open source supercomputing-based Serratus Project identified over 130,000 RNA-based viruses, including 9 coronaviruses. ...

https://en.wikipedia.org/wiki/January–March_2022_in_science

Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, ... Immunotherapy has become an important part of hematopoietic stem cell (HSC) transplantation and cancer therapy. ... Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, ... Cell- and Tissue-Based Therapy* / methods * Cell- and Tissue-Based Therapy* / trends ...

https://pubmed.ncbi.nlm.nih.gov/20078383/

... has been proposed as a therapy for diabetes. We describe a seven-stage protocol that efficiently converts hESCs into insulin- ... producing cells. Stage (S) 7 cells expressed key markers o … ... insulin-secreting cells derived from human embryonic stem cells ... Cell- and Tissue-Based Therapy* * Diabetes Mellitus / pathology * Diabetes Mellitus / therapy* * Embryonic Stem Cells / ... Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells Nat Biotechnol. 2014 Nov; ...

https://pubmed.ncbi.nlm.nih.gov/25211370/?dopt=Abstract

Introduction to Human Cellular and Tissue Based Products (HCT/P), Cell Therapy and Gene Therapy. ... Cell and Gene Therapies, and Other Advanced Therapies. Recorded October 18-19, 2023. ... Cell and Gene Therapies, and Other Advanced Therapies Course in October 2023. ... Foods Developed Using Biotechnology and Animal Cell Culture Technology - US Regulatory Oversight. ...

https://www.fdli.org/2023/10/introduction-to-fda-review-and-approval-of-biological-products/

Lai RC, Chen TS, Lim SK: Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen Med ... Adipose tissue-derived mesenchymal stem cells. AD-MSC were obtained from the adipose tissue of 10 non-obese donors (4 men and 7 ... A wide range of evidence indicates that paracrine effects of MSC are a central mechanism of cell therapy promoting tissue ... MSC cell therapy has demonstrated beneficial effects despite short-lived survival of the delivered cells suggesting that ...

https://karger.com/cpb/article/47/1/11/75503/Microvesicles-from-Human-Adipose-Tissue-Derived

However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the ... Based on the conducted experiments, in-process quality control (QC) parameters and acceptance criteria were defined for the ... Critical process parameters (including, e.g., the concentration of enzyme used for AT digestion, cell culture conditions) were ... represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely ...

https://www.mdpi.com/2073-4409/10/8/1908

https://en.wikipedia.org/wiki/Institute_for_Bioengineering_of_Catalonia

Promising results from small case studies and early clinical trials hint at the potential of CAR-T cell therapy to treat -- and ... that recognizes tissue-specific antigens and suppress inflammation at the site of the disease. "Treg based cell therapies are ... While standard CAR T-cell therapies under clinical investigational up to now all use effector T cells, regulatory T cells ( ... but these engineered CD19-targeted T cells can reach B cells sitting in tissues in a way that antibody therapies cannot, Konig ...

https://www.medscape.com/viewarticle/996883

"361" Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps). Michelle McClure, Ph.D. provides an overview of the ... OTP-regulated products include gene therapy, tumor vaccines, xenotransplantation, stem cells, human tissue for transplantation ... Determining Eligibility of a Donor of Human Cells, Tissues, or Cellular or Tissue-Based Products (HCT/Ps). Michelle McClure, Ph ... reviews the process for determining the eligibility of potential donors of human cells, tissues, and cellular and tissue-based ...

https://www.fda.gov/vaccines-blood-biologics/news-events-biologics/otp-learn

Hematology, Hemotherapy Service, Bone Marrow Transplantation, Cell- and Tissue-Based Therapy, Hematologic Diseases, Neoplasms ...

https://bvsalud.org/en/direve/?filter=descriptor:Hematology+AND+thematic_area_display:pt-br^Preven%C3%A7%C3%A3o+e+Controle+de+C%C3%A2ncer+(Nacional)|en^Cancer+Prevention+and+Control+(National)|es^Prevenci%C3%B3n+y+Control+del+C%C3%A1ncer+(Nacional)

According to ESACT, the award recognizes outstanding innovators in the field of Animal Cell Culture Technology (ACCT) and ... Keywords: Awards and Prizes; Bioreactors; Batch Cell Culture Techniques; Vaccines; Cell- and Tissue-Based Therapy; Genetic ... and cell and gene therapies. GÖTTINGEN, Germany, June 28, 2022 / B3C newswire / -- Sartorius, a leading international partner ... According to ESACT, the award recognizes outstanding innovators in the field of Animal Cell Culture Technology (ACCT) and ...

https://www.b3cnewswire.com/202206282368/richard-wales-ph-d-and-neil-bargh-of-sartorius-honored-as-recipients-of-2022-esact-innovation-award-for-the-development-of-the-sartorius-ambr-technology.html

... healthy tissue. Other possibilities include gene and cell-based therapies that replace, repair, or up-regulate specific genes, ... Gene and cell-mediated therapies for muscular dystrophy. Muscle Nerve. 2013 May. 47(5):649-63. [QxMD MEDLINE Link]. ... Stem cell therapies hold potential to replace diseased muscle with new, ... An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells. Nat Commun. 2013. 4:1549. ...

https://emedicine.medscape.com/article/321397-overview

Proposal form for a new Approved Cell and Tissue Name (ACN) ... cell based derivatives and other emerging biological therapies. ... human and living animal cells and tissues. The Biologicals Framework covers blood, blood components, tissue & cellular products ... Proposed name for a cell and tissue ingredient (ACN) used in therapeutic goods [PDF, 135.37 KB] ... Proposed name for a cell and tissue ingredient (ACN) used in therapeutic goods [Word, 127.49 KB] ...

https://www.tga.gov.au/resources/resource/forms/proposal-new-approved-cell-tissue-name-acn-application-form

Advancing Gene, Cell, & Tissue-Based Therapies 2020 [cited 2020 Mar 15].. 2. Forsberg, N.e.a. Key Considerations in Gene ... Cell Therapy Manufacturing and Compliance. Cell Therapy Manufacturing and Compliance. Jun 15, 2023. ... How does this translate to cell therapy, where the cells are the starting and ending material? When specifically discussing ... The success of cell and gene therapy development is heavily dependent on the strength of its process controls for repeatability ...

https://www.labmanager.com/seven-ways-osmolality-testing-improves-cell-gene-therapy-process-development-and-manufacturing-29778

Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7:211-228. [PubMed] [DOI] ... STEM CELL THERAPY: ANIMAL STUDIES. The use of stem cell therapy in the regeneration of musculoskeletal tissue is a very dynamic ... Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13:4279-4295. [PubMed] [DOI] [Cited in This ... Adipose tissue MSC. Adipose Tissue derived stem cells (AMSC) have also shown multipotentiality in vitro[66]. Due to its ...

https://www.wjgnet.com/1948-0210/full/v7/i4/691.htm

... whether their technology could repair lungs damaged by COVID-19 and testing a new treatment based on inhalation therapy, where ... to influence the type of tissue they develop into, and then implanting this tissue into the body. "You cannot fool the cells," ... which manufactures tissue-specific substrates to support cell growth; and Immplacate Health, which is using mesenchymal stem ... Professor of Dental Medicine and Director of the Laboratory for Stem Cells and Tissue Engineering at Columbia University, New ...

https://www.prweb.com/releases/honoring_a_pioneer_in_tissue_engineering_gordana_vunjak_novakovic_named_european_inventor_award_2021_finalist/prweb17908865.htm

... researchers report that partially methylated domains and differentially methylated domains found in tumor cells are present in ... Single-Cell MRD Assay Helps Characterize Cells Surviving Acute Myeloid Leukemia Therapy ... In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment ... Where these PMDs fall in the genome is present in normal cells, they report, but note that tumor cells exhibit a higher level ...

https://www.genomeweb.com/scan/analysis-methylation-esophageal-tumors-nonmalignant-tissue

Stem cells collected from human corneas restore transparency and dont trigger a rejection response when injected into eyes ... The findings suggest that cell-based therapies might be an effective way to treat human corneal blindness and vision impairment ... "Several kinds of experiments indicated that the human cells were alive and making lumican, and that the tissue had rebuilt ... Tags: B Cell, Blindness, Cell, Clinical Testing, Cornea, Eye, Eye Disease, Eye Surgery, G-Protein, Immune Response, Immune ...

https://www.news-medical.net/news/2009/04/12/48233.aspx

... commercial opportunities and collaboration in the advanced therapies and regenerative medicine space. ... There, his work focused on vascularization of 3D tissue and cell-based drug delivery. ... Cell Therapy @ 16:00. The latest advances on a monitoring system integrated bioreactor for 3D cell culture. Sebastian Kress, ... Sebastian Kress is a postdoctoral scientist at the Institute of Cell and Tissue Culture Technologies at BOKU, Vienna, Austria. ...

https://www.terrapinn.com/virtual/advanced-therapies/speaker-sebastian-KRESS.stm

Stem cell therapy. Researchers at the University of Queensland, Australia, have had some success with a tissue engineering- ... based approach using stem cells.. The aim is to encourage functional cartilage to generate itself, using an injectable hydrogel ... The researchers concluded that stem cell therapy might be useful for intervertebral disc regeneration. ... Multiple sclerosis: How stem cell therapy could become a treatment for MS ...

https://www.medicalnewstoday.com/articles/266630?utm_source=ReadNext

Cell and tissue based products. *Chemical and electro cautery. *Compression. *Hyperbaric oxygen therapy ... Respiratory Therapy The focus of Tri-State Respiratory Therapy, also known as "Cardio-Pulmonary", is to diagnose and treat ... It is particularly useful in evaluating palpable lumps, soft tissue masses, and cysts. It is often the first choice for image- ... The Renal Dialysis Center also offers two Home Therapy Programs to choose from, Home Hemodialysis and Home Peritoneal Dialysis ...

https://www.tsh.org/tristate-at-a-glance/

... with both narrowed and obliterated airways with surrounding fibrous tissue and a variable mixed chronic inflammatory cell ... Based on this result, she received a diagnosis of obliterative bronchiolitis. At the patients most recent evaluation in April ... Although inhaled steroids and mucus clearance therapy improved her cough, her dyspnea continued to worsen; an open lung biopsy ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6216a3.htm

We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial ... However, there is no validated therapy for it. Dysregulation of microRNAs has been confirmed to be involved in cardiac fibrosis ... These contradictory conclusions indicated that miR-409-3p plays complex tissue-based specific roles in various tumor cells. ... resulting in stiffer tissue and cardiac dysfunction. Therefore, effective antifibrotic therapies are essential to improving ...

https://www.hindawi.com/journals/omcl/2022/8922246/

While the work was a major breakthrough, it left two major challenges for the field to solve before iPS cell therapy could be ... The research makes great strides in addressing a major practical challenge in the development of stem-cell-based medicine. ... The creation of iPS cells from adult cells sidesteps ethical concerns associated with the use of embryonic stem cells, and ... A Major Step in Making Better Stem Cells from Adult Tissue. patitut Januari 1, 2023 Leave a Comment ...

https://x-journals.com/a-major-step-in-making-better-stem-cells-from-adult-tissue

Learn about the role of 3D cells in tissue engineering and the 3D systems being researched to bring us closer to regenerating ... Tissue engineering offers promise for the future of joint replacement. ... But while chondrocyte-based therapies have been available in the clinic and some in clinical trials, many of those products ... Tissue Engineering Scaffolds for 3D Cell Culture. Pioneering tissue engineering studies used traditional 2D substrates, but in ...

https://www.corning.com/in/en/products/life-sciences/resources/stories/the-cutting-edge/the-future-of-joint-replacement-is-tissue-engineering.html

... embryonic and adult stem cells and they act as a repair system by replenishing body tissue. Stem cells differe ... Mandpe, P.; Prabhakar, B.; Shende, P. Role of liposome-based stem cells for multimodal cancer therapy. Stem Cell Rev. Rep., ... Engineered biomaterials to enhance stem cell-based cardiac tissue engineering and therapy. Macromol. Biosci., 2016, 16(7), 958- ... Stem Cell Therapy: A Promising Approach in Treatment of COVID-19. Current Stem Cell Research & Therapy ...

https://www.benthamscience.com/article/105864

This new concept could help advance adaptive T cell therapies by producing desired patient-specific T cell populations in the ... Researchers have engineered a tissue-mimicking hydrogel model to show that more elastic tissues induce T cells to become ... effector-like T cells with strong tumor-killing potential, while more viscous tissues induce them to become memory-like T cells ... T cells experience different mechanical signals in different tissues. ...

https://www.sciencedaily.com/releases/2023/06/230626164232.htm

The tissue environment shapes the lipid recognition capacity of natural killer T cells. ... These findings may inform future development of novel therapies based on the manipulation of iNKT cells for vaccination or ... Since iNKT cells are tissue-resident cells an important question remains regarding whether the iNKT cell TCR repertoire (and ... and T cells (blue) from the depicted tissues of Nur77GFP mice. iNKT cells from the tissues of Nur77GFP- mice are shown as ...

https://elifesciences.org/articles/51663

The global stem cell therapy market in terms of revenue was estimated to be worth $257 million in 2022 and is poised to reach $ ... The adipose tissue-derived stem cell segment dominated the stem cell therapy indsutry.. Based on cell source, the stem cell ... STEM CELL THERAPY IN USA): CELL THERAPY MARKET, BY CELL SOURCE, 2020-2027 (USD MILLION). TABLE 74 US (STEM CELL THERAPY IN USA ... The allogeneic stem cell therapy accounted for the largest share of the stem cell therapy industry. The stem cell therapy ...

https://www.marketsandmarkets.com/Market-Reports/stem-cell-technologies-and-global-market-48.html

... drugs would be applied at exactly the therapeutic concentration and would precisely target desired cells or tissues. However, ... Tumour model is based on the modified PhysiCell model. The PhysiCell model was modified by introducing heterogeneity on cell ... Periodic Reporting for period 2 - EVO-NANO (Evolvable platform for programmable nanoparticle-based cancer therapies). Reporting ... 2. Developed initial implementation of the multiscale tumour simulator as a combination of agent based and stochastic based ...

https://cordis.europa.eu/project/id/800983/reporting

Although graphene/stem cell-based tissue engineering has recently emerged and has promisingly and progressively been utilized ... because graphene-based neuronal tissue engineering can promisingly realize the regenerative therapy of various incurable ... Although graphene/stem cell-based tissue engineering has recently emerged and has promisingly and progressively been utilized ... Graphene scaffolds in progressive nanotechnology/stem cell-based tissue engineering of the nervous system O. Akhavan, J. Mater ...

https://pubs.rsc.org/en/content/articlelanding/2016/tb/c6tb00152a

The principles and practices of the diverse aspects of immune therapy for cancer, HSC transplantation and regenerative medicine have many commonalities. (nih.gov)
Before, he was employed at the department of Tissue Engineering and Regenerative Medicine at the University Hospital Würzburg, Germany. (terrapinn.com)
Ramalingam, M. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. (benthamscience.com)
For instance, in September 2021, the California Institute for Regenerative Medicine granted a grant of USD 31 million to Stanford Research for launching first-in-human trials of stem cells in the treatment of heart failure, stroke, and spinal cord tumours. (marketsandmarkets.com)
Since there has been no in vivo application of graphene in neuronal regenerative medicine, we hope that this review can excite further and concentrated investigations on in vivo (and even in vitro ) neural proliferation, stimulation and differentiation of stem cells on biocompatible graphene scaffolds having the potential of degradability for the generation of implantable neuronal networks. (rsc.org)
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. (ca.gov)
The Company develops regenerative medicine products that interrupt the inflammatory cascade that leads to pain, including its two leading stem cell technologies, Progenza™ - which has been licenced to Kyocera for the treatment of knee osteoarthritis in Japan, and Sygenus - which is in pre-clinical stage. (regeneus.com.au)
This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. (routledge.com)
This pressing need has led to the rise of 'tissue engineering and regenerative medicine', a multidisclinary field which aims to induce the body's natural regenerative abilities and produce functional substitutes of biological tissue for clinical use. (edu.au)
Tissue engineering and regenerative medicine can provide a novel treatment regime based on the use of synthetic biomaterials, which may be constructed into three-dimensional implants and combined with biologics (such as cells and/or bioactive molecules). (edu.au)
Stem cell-based regenerative medicine shows much promise. (selectbiosciences.com)

Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
This naturally occurring process - called MET (mesenchymal to ephithelial cell transition) - pushes fibroblasts closer to a stem-cell-like state. (x-journals.com)
Based on cell source, the stem cell therapy market is segmented into adipose tissue-derived MSCs (mesenchymal stem cells), placental/umbilical cord-derived MSCs, bone marrow-derived MSCs, and other sources. (marketsandmarkets.com)
Regeneus' technology is based on Mesenchymal Signalling Cells (MSC) and their Secretome. (regeneus.com.au)
A selected list of scientific publications related to Regeneus, Mesenchymal Signalling Cells (MSC) and their Secretome. (regeneus.com.au)
Our lead cell therapy candidate, BRTX-100, is a product formulated from autologous (or a person's own) cultured mesenchymal stem cells collected from the patient's bone marrow. (biospace.com)
6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)

Compelling clinical successes and recent drug approvals have fueled ongoing investments in this exciting area of therapeutic research, with over 1,000 therapies in clinical trials at the end of 2019 [1]. (labmanager.com)
In the ideal case, drugs would be applied at exactly the therapeutic concentration and would precisely target desired cells or tissues. (europa.eu)
Stem cell research funding has strengthened in the past few years, attributed to the need for novel therapeutic interventions in patients with cardiovascular, neurological, and autoimmune disorders. (marketsandmarkets.com)
Studies exploring the therapeutic potential of embryonic stem cells (ESC) are associated with various ethical issues attributed to the destruction of human embryos. (marketsandmarkets.com)
In 2021, the adipose tissue-derived stem cells segment dominated stem cell therapy with the highest revenue share, which was attributed to the growing adoption of these MSCs across different therapeutic indications. (marketsandmarkets.com)
Based on therapeutic application, the stem cell therapy market is segmented into musculoskeletal disorders, cardiovascular diseases, wounds and injuries, neurological disorders, surgeries, inflammatory and autoimmune diseases, and other therapeutic applications. (marketsandmarkets.com)
He also consults on patients for precision oncology, partnering with the Institute for Genomic Medicine to identify therapeutic approaches based on patient tumor and germline genomics. (spotify.com)
In this regard, cell-based therapy may be an alternative therapeutic approach. (lu.se)
This work not only presents a novel model to study the mechanisms of human astrocytes in vitro , but also provides an ideal platform for further interrogation of early astroglial cell autonomous events in AD and the possibility of identification of novel therapeutic targets for the treatment of AD. (nature.com)
Stem cell-based therapies offer a potential therapeutic approach to repair, restore, or regenerate injured brain tissue. (lu.se)
BioRestorative Therapies, Inc. ( www.biorestorative.com ) develops therapeutic products using cell and tissue protocols, primarily involving adult stem cells. (biospace.com)
Novel culture and cryopreservation systems for human pluripotent stem cells and neural stem cells will be presented and their advantages and applicability in the production of high quality advanced therapeutic products or functional screening tools for preclinical research discussed. (selectbiosciences.com)
The opportunities and challenges of development of stem cell-based therapeutic interventions for joint surface repair for the treatment and prevention of osteoarthritis will be discussed. (selectbiosciences.com)
This presentation will describe the current status of strategies to generate induced pluripotent stem (iPS) cells from mouse and human somatic cells for patient-specific disease modeling and cell therapeutic applications. (selectbiosciences.com)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
Based on their properties, researchers have also been exploring CNTs potential for biological and biomedical applications as drug delivery systems, substrate for cells growth in tissue regeneration, therapeutic agents, or as vectors for gene transfection. (cdc.gov)
MSCs have great therapeutic potential in tissue engineering, they can be expanded in vitro, and combined with scaffolds they can be inserted into wounds to promote healing and tissue replacement. (bvsalud.org)
The potential therapeutic use of stem cells has been broadly researched in recent years. (bvsalud.org)
The stem cells from exfoliated deciduous teeth (SHEDs) have a great potential for therapeutic use because of its differentiation capability and its easy access, since the collection is performed at the physiological exfoliation stage of the deciduous teeth. (bvsalud.org)
These sophisticated cells will hopefully provide a new potent therapeutic avenue for currently untreatable tumors. (lu.se)

Transplantation of pancreatic progenitors or insulin-secreting cells derived from human embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. (nih.gov)
A team led by scientists from The Scripps Research Institute has developed a method that dramatically improves the efficiency of creating stem cells from human adult tissue, without the use of embryonic cells. (x-journals.com)
The creation of iPS cells from adult cells sidesteps ethical concerns associated with the use of embryonic stem cells, and allows the generation of stem cells matched to a patient's own immune system, avoiding the problem of tissue rejection. (x-journals.com)
In the paper, the researchers demonstrated that they could use purified proteins to transform adult cells all the way back to the most primitive embryonic-like cells, avoiding the problems associated with inserting genes. (x-journals.com)
Background: Stem cells are of two types: embryonic and adult stem cells and they act as a repair system by replenishing body tissue. (benthamscience.com)
Melton, D.A. "Stemness": Transcriptional profiling of embryonic and adult stem cells. (benthamscience.com)
Subpopulations of human embryonic stem cells with distinct tissue-specific fates can be selected from pluripotent cultures. (ca.gov)
In contrast, CD135(+)GFP(+) hESCs gave rise to tissues representing all three embryonic germ layers, and were virtually indistinguishable from CD135(-)-derived tissues. (ca.gov)
We generated light-sensitive human embryonic stem cell (hESC)-derived GABAergic interneurons (hdIN) and tested their functionality. (lu.se)
and 3) cell-based therapies derived from human embryonic stem cells for treatment of various chronic diseases. (waymarking.com)
Clinical use of human embryonic stem (hES) cells is already being explored in a several phase1 safety trials. (selectbiosciences.com)
Stem cells are classified into two main: embryonic stem cells, which are found in the embryos and adult stem cells, found in adult tissues. (bvsalud.org)
Embryonic stem cells are present only in the early stages of development and are able to generate any cell type (Pluripotent Stem Cells). (bvsalud.org)

Therefore, although S7 cells are not fully equivalent to mature beta cells, their capacity for glucose-responsive insulin secretion and rapid reversal of diabetes in vivo makes them a promising alternative to pancreatic progenitor cells or cadaveric islets for the treatment of diabetes. (nih.gov)
95% homogeneous populations of human astrocytes within 30 days of differentiation from cortical neural progenitor cells (NPCs). (nature.com)
Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. (jcadonline.com)
Until now, several progenitor cells derived from dental tissues have been isolated and characterized ( table I ). (bvsalud.org)

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)
These four genes then produced transcription factors turning on and off other genes, and pushing the cell to "dedifferentiate" into stem cells. (x-journals.com)
Using its proprietary GalXC™ and GalXC-Plus™ RNAi technologies, Dicerna develops RNAi-based therapies to selectively silence genes that cause or contribute to disease. (novonordisk.com)
Some inherited genes cause diseases such as Tay-Sachs or sickle cell anemia, while mutations in genes can cause genetic disorders, such as Down syndrome. (sutterhealth.org)
Advanced Therapy Medicinal Products (ATMPs) are revolutionary medicines based on cells, tissues, or genes. (lu.se)

The global stem cell therapy market in terms of revenue was estimated to be worth $257 million in 2022 and is poised to reach $558 million by 2027, growing at a CAGR of 16.8% from 2022 to 2027. (marketsandmarkets.com)
Nov. 16, 2022 (GLOBE NEWSWIRE) -- BioRestorative Therapies Inc. ("BioRestorative" or the "Company") (Nasdaq: BRTX), a clinical stage company focused on the development of first-in-class cell-based therapies, today announced that it will participate on December 5-6, 2022 at the RHK Capital Disruptive Growth Conference in New York City. (biospace.com)

Immunotherapy has become an important part of hematopoietic stem cell (HSC) transplantation and cancer therapy. (nih.gov)
She has dedicated her decades-long career to developing an ex vivo tissue engineering technique which offers a safer, more precise way of cultivating skeletal, heart, lung, and vascular tissue for either transplantation, disease modelling, or drug testing. (prweb.com)
The current popularity of LASIK corrective eye surgery is expected to substantially reduce the availability of donor tissue because the procedure alters the cornea in a way that makes it unsuitable for transplantation. (news-medical.net)
Although graphene/stem cell-based tissue engineering has recently emerged and has promisingly and progressively been utilized for developing one of the most effective regenerative nanomedicines, it suffers from low differentiation efficiency, low hybridization after transplantation and lack of appropriate scaffolds required in implantations without any degrading in functionality of the cells. (rsc.org)
In co-culture with human cortical neurons and after transplantation (AT) into human brain tissue resected from patients with drug-resistant epilepsy, light-activated channelrhodopsin-2 (ChR2) expressing hdINs induced postsynaptic currents in human neurons, strongly suggesting functional efferent synapse formation. (lu.se)
We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
as well as diagnostic techniques, drug development and tissue transplantation. (who.int)
Based on these observations, the dopamine neu- from dopamine neurons implanted into the brain pa- rons used for transplantation in these experiments renchyma with the goal of reinnervating the dener- were neuroblasts obtained from mid-trimester rat vated striatum.8,9 Rats with unilateral, 6-hydroxydo- fetuses. (lu.se)

This meeting report summarizes a workshop sponsored by the National Heart, Lung and Blood Institute (NHLBI) and Production Assistance for Cellular Therapies (PACT), held on 23-24 April 2009 at the National Institutes of Health (NIH, USA). (nih.gov)
Are Cellular Therapies the Future of Autoimmune Disease? (medscape.com)
But this is only the tip of the iceberg regarding cellular therapies for autoimmune disease, said Max Konig, MD, PhD , an assistant professor of medicine in the division of rheumatology at Johns Hopkins University School of Medicine in Baltimore. (medscape.com)
Existing biotech business models are sorely stretched when applied to cellular therapies. (selectbiosciences.com)

Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. (nih.gov)
Consistent with this, iNKT cells from different organs show distinct basal activation, proliferation and clonal expansion. (elifesciences.org)
Most anatomical compartments, including mucosal surfaces and solid organs, host large populations of tissue-resident lymphocytes which are uniquely placed to provide local networks for immune surveillance and defence against infection ( Fan and Rudensky, 2016 ). (elifesciences.org)
Image-Guided Radiation Therapy (IGRT) - Provides precise targeting with frequent imaging when the tumor is likely to move (lung or prostate) or is near critical organs. (sutterhealth.org)
All diseases, including neurological disorders, can be broadly defined as homeostatic failures within tissues, organs or systems. (nature.com)
The worldwide shortage of donor organs and drawbacks of surgical methods have created significant challenges in repairing and replacing diseased or damaged tissues and organs. (edu.au)
We aim to gain a better understanding of the relationship between T cell functions and their physical microenvironment by 3D printing hydrogels as a model for the soft tissues and organs in our bodies. (edu.au)
Tissue engineering is the science that combines the principles of biology and engineering techniques in order to obtain biological substitutes for regenerating, replacing, modifying, repairing or restoring the function of organs and tissues. (bvsalud.org)

A Pioneer in Cell therapy treatment Regeneus began our mission in autologous cell therapy for patients suffering from arthritis, we utilized our experience and knowledge to shift to innovative allogeneic cell therapy for broader application, democratizing MSCs for the treatment of pain for millions of everyday people. (regeneus.com.au)
To repair tissue and decrease inflammation, MSCs communicate via signalling molecules produced by the cells themselves, restoring the balance and calming the inflammatory state. (regeneus.com.au)
MSCs versus stem cell-based interventions other than MSCs. (lu.se)
11 However, the greater the abundance of adipose tissue in the human body, the significantly higher the yield of MSCs is compared to other tissues. (jcadonline.com)
MSCs have a clinical attractiveness because they are easy to expand, they have the ability to differentiate into various types of tissues 5 , and can be directed to become osteocytes, chondrocytes or adipocytes. (bvsalud.org)

Among various stem cells, neural stem cells (NSCs) and their neural differentiation on graphene have attracted a lot of interest, because graphene-based neuronal tissue engineering can promisingly realize the regenerative therapy of various incurable neurological diseases/disorders and the fabrication of neuronal networks. (rsc.org)
Hence, in this review, we further focused on the potential bioapplications of graphene-based nanomaterials for the proliferation and differentiation of NSCs. (rsc.org)
The challenge for existing stem cell-based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo , because stem cells are rather sensitive to even minute changes in their environment. (routledge.com)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)

The cornea and its stromal stem cells themselves appear to be "immune privileged," meaning they don't trigger a significant immune response even when transplanted across species, as in the Pitt experiments. (news-medical.net)
In this review, we discuss the potential influence of stromal vascular fraction from adipose tissue in the management of alopecia as well as its involvement in preclinical and clinical trials. (jcadonline.com)
however, a variety of other cell types are found as well, collectively labeled as stromal vascular fraction (SVF). (jcadonline.com)

Cell-based and gene therapy products, such as advanced therapy medicinal products (ATMPs), have become a game-changer in individual therapy as they pave the way for a new era in medical treatment. (ispe.org)
Mark your calendar and dive into the fascinating world of advanced therapy medicinal products! (ispe.org)
Welcome to the National Advanced Therapy Medicinal Products (ATMP) Research School, where our mission is to advance the knowledge and expertise needed in the development of cell, gene, and tissue-based therapies in Sweden. (lu.se)

The term muscular dystrophy (MD) refers to a heterogeneous group of genetic disorders that typically result in progressive degeneration followed by incomplete regeneration of skeletal muscles, ultimately resulting in the loss of contractile tissue. (medscape.com)
Bach, E.A. JAK/STAT signaling in stem cells and regeneration: From drosophila to vertebrates. (benthamscience.com)
To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. (routledge.com)
Our work aims to develop optimal tissue engineered constructs for the repair and regeneration of different types of musculoskeletal tissues, including bone, cartilage and tendon. (edu.au)
The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)
The development of new biomaterials for tissue engineering provides a scientific basis for the creation of scaffolds that could provide appropriate regeneration and tissue repair 14 . (bvsalud.org)
The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
The tissues that used to be discarded may now serve as a basis for scientific research and clinical use in tissue regeneration and treatment of many diseases 23 . (bvsalud.org)

However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)

Researchers have explored combinations of biomaterials, cells, and bioactive factors, using them to generate new cartilage and bone tissue in vitro and in vivo . (corning.com)
Engineering cartilage has typically involved 'encapsulating chondrocytes, or stem cells which can be differentiated along a chondrogenic linage, in a supportive matrix such as a hydrogel or scaffold,' Advanced Healthcare Materials explains. (corning.com)
Now, potential engineered-tissue cartilage products are beginning to be formed through biofabrication. (corning.com)

The stem cell therapy market is segmented into allogeneic and autologous stem cell therapies based on type. (marketsandmarkets.com)

Market growth is driven mainly by factors such as robust funding for stem cell research, an increase in the number of cell therapy production facilities that have GMP certification, and growth in the number of clinical trials associated with stem cell therapies. (marketsandmarkets.com)
The surge in the expanding number of clinical trials is further triggered by the COVID-19 pandemic, with a vast number of clinical trials studying the potential of stem cell therapies in the treatment of SARS-CoV-2 infection. (marketsandmarkets.com)
Comparatively fewer complications are associated with the development and manufacturing of allogeneic stem cell therapies, which is the key attributive reason for their largest share in the market. (marketsandmarkets.com)
This has also led to an increase in the number of clinical trials regarding the development of allogeneic stem cell therapies, making it the fastest growing segment during the forecast period. (marketsandmarkets.com)

Since then, two biotechnology companies - Cabaletta Bio in Philadelphia and Kyverna Therapeutics in Emeryville, California - have already been granted fast-track designations from the US Food and Drug Administration for CAR T-cell therapy for SLE and lupus nephritis . (medscape.com)
Dicerna is a publicly held company focusing on RNAi-based therapeutics. (novonordisk.com)
Details are provided about the quantitative market opportunity for various stem cell classes as well as the current state of the clinical trials space wherein stem cell-based therapeutics are being evaluated for therapy in various disease classes. (selectbiosciences.com)

In the 1980s, when Vunjak-Novakovic began her career, the mainstream approach was to combine cells and biomaterials, and insert them into the body, with the intention of this transplant finding a way to regenerate tissues. (prweb.com)
Pioneering tissue engineering studies used traditional 2D substrates, but in recent years, research has focused on the development of biomimetic 3D scaffolds and cell culture platforms to repair and regenerate osteoarthritis' osteochondral defects, according to Bio-Design and Manufacturing . (corning.com)
While cell therapy utilises cells to repair, regenerate or replace damaged tissue, gene therapy involves the introduction or modification of genetic material to treat or prevent diseases. (ispe.org)

Vunjak-Novakovic's pioneering technique involves creating living biological grafts by growing a new piece of tissue ex vivo from a patient's own cells, entirely eliminating these problems. (prweb.com)
This research utilizes a variety of cell biology, molecular biology, biochemistry, imaging and in vivo techniques. (pitt.edu)
Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)

Stage (S) 7 cells expressed key markers of mature pancreatic beta cells, including MAFA, and displayed glucose-stimulated insulin secretion similar to that of human islets during static incubations in vitro. (nih.gov)
The pathological potential of human astroglia in Alzheimer's disease (AD) was analysed in vitro using induced pluripotent stem cell (iPSC) technology. (nature.com)
We are working to generate red blood cells in vitro from pluripotent stem cells, however the extremely large cell numbers involved pose unique challenges to culture technology and scale-up. (selectbiosciences.com)
1997. In vitro genotoxic effects of hard metal particles assessed by alkaline single cell gel and elution assays. (cdc.gov)

This session was recorded as part of FDLI's Introduction to Biological Products, Including Vaccines, Biosimilars, Cell and Gene Therapies, and Other Advanced Therapies Course in October 2023. (fdli.org)

Results: To increase the viability of stem cells, techniques like scaffolds of stem cells with hydrogel or alginate, pre-conditioning, different routes of administration and encapsulation, are implemented. (benthamscience.com)
The possibility of degradation of graphene scaffolds (NIR-assisted photodegradation of three-dimensional graphene nanomesh scaffolds) was also discussed based on the latest achievements. (rsc.org)
Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. (routledge.com)
The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
tissue scaffolds. (bvsalud.org)

However, there are numerous uses for testing throughout any bioproduction workflow, and cell and gene therapy development will certainly benefit from additional exciting applications. (labmanager.com)
Achieving high transfection efficiency is critical for high viral titer yield, but it is common to see subpar transfection efficiencies in gene therapy development. (labmanager.com)
In Track 3 of the conference, we will introduce you to the concept and commercialisation of ATMPs and cell and gene therapy. (ispe.org)
Surely, you have heard about cell and gene therapy. (ispe.org)
Cell and gene therapy has been used to treat various types of diseases, including cancer, neurological disorders, autoimmune diseases, genetic disorders, and viral infections. (ispe.org)
From the Centre of Cell Manufacturing Ireland (CCMI), Andrew Finnerty will offer the audience insights into the challenges of commercialising cell and gene therapy treatments that have so far been state-EU funded. (ispe.org)
It is already known that rAAVs can transport genetically encoded material into any type of cell and tissue, including the brain, and that, once inside the cells, they are capable of repeatedly switching gene therapy applications on and off again. (sciencedaily.com)
While this does not mean that future gene therapy applications are guaranteed to be successful, the researchers are full of confidence for the future. (sciencedaily.com)

But Konig stressed that we are still in the early days of clinical trials, and more research is necessary to understand the safety and efficacy of these therapies. (medscape.com)
But while chondrocyte-based therapies have been available in the clinic and some in clinical trials, many of those products have not demonstrated efficacy, and significant translational challenges remain. (corning.com)

To precisely target cancer cells and spare healthy tissue, radiation oncologists at Mills-Peninsula Medical Center use state-of-the-art radiation therapies. (sutterhealth.org)
At Sutter's nine cancer centers, radiation oncologists use a range of radiation therapies to destroy cancer cells and spare healthy tissue. (sutterhealth.org)
To precisely target cancer cells and spare healthy tissue, radiation oncologists at CPMC's Cancer Center use innovative radiation therapies. (sutterhealth.org)
At California Pacific Medical Center's certified cancer center, radiation oncologists use a range of radiation therapies to destroy cancer cells and spare healthy tissue. (sutterhealth.org)

By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)

The following bioengineering laboratories are currently housed at the Center: Musculoskeletal Research Center, MSRC, (Dr. Savio Woo), Cardiovascular Systems Laboratory (Dr. Sanjeev Shroff), Bioengineering Methods and Applications Laboratory and BioTransport Laboratory (Dr. Jack Patzer), Vascular Bioengineering Laboratory (Dr. David Vorp), Cell Migration Laboratory (Dr. Partha Roy), Computational Biomechanics Laboratory (Dr. Spandan Maiti) , Orthopaedic Robotics Laboratory (Drs. Volker Musahl and Richard Debski) and Molecular Biological and Biophysical Core Facilities (Department). (pitt.edu)
Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
2004. Corrosion of tungsten coils after peripheral vascular embolization therapy: Influence on outcome and tungsten load. (cdc.gov)

Osteochondral tissue engineering is the additive technology that 'makes it possible to spatially pattern cells, bioactive factors, and biomaterials in 3D,' Advanced Healthcare Materials asserts. (corning.com)
Our tissue engineering research focuses on repairing diseased or damaged tissues, incorporating the areas of biomaterials, stem cells, computer modelling and molecular biology. (edu.au)

Over her lifetime, Gordana Vunjak-Novakovic has made a major contribution to tissue engineering, one of the most promising ways to prolong the human lifespan and improve quality of life," said EPO president António Campinos, announcing the 2021 EPO Award finalists. (prweb.com)

ATMPs offer a range of benefits over traditional drugs and therapies. (ispe.org)

Ding and colleagues essentially solved the first problem, the reliance on genetic manipulation, earlier this year in a paper published in Cell Stem Cell (Volume 4, Issue 5, May 8, 2009). (x-journals.com)
Many cancer drugs now target specific genetic changes, called driver mutations, that allow tumor cells to grow and spread. (nih.gov)
To find out whether a person's cancer has driver mutations that can be targeted with one of these new drugs, doctors perform genetic testing of tumor tissue samples. (nih.gov)
Therefore, decisions about whether to treat someone with a targeted therapy are usually based on genetic testing of the original (primary) tumor. (nih.gov)
Researchers have now programmed a virus to transport the necessary genetic material to affected tissue and nerve cells inside the body. (sciencedaily.com)
Led by Dr. Mazahir T. Hasan, and working under the auspices of the NeuroCure Cluster of Excellence, the team has successfully programmed a virus to transport the necessary genetic material to affected tissue and nerve cells inside the body. (sciencedaily.com)
The fact that rAAV-infected cells do not trigger any form of measurable immune response and that their genetic material remains completely intact represents an additional benefit. (sciencedaily.com)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
By developing state-of-art genetic circuits and synthetic biology we strive to bring forward curative immune cell therapies. (lu.se)

Mice that lack the ability to produce lumican develop opaque areas of their corneas comparable to the scar tissue that human eyes form in response to trauma and inflammation, Dr. Funderburgh said. (news-medical.net)
The efficiency of transplanted stem cells reduces due to conditions like hypoxia, inflammation, nutrient deprivation, immunogenicity, extracellular matrix loss on delivery and mechanical stress. (benthamscience.com)
Pain and inflammation are responsible for a series of events leading to immune cells reacting to damaged tissue, causing chronic and acute illness. (regeneus.com.au)
A needle core biopsy of the lung nodule on day 4 revealed necrotizing granulomatous inflammation consisting of epithelioid histiocytes associated with intracellular narrow-based budding yeast ( Figure 1 , panels B, C) and multinucleated giant cells ( Figure 1 , panel A). Yeast forms 2-5 μm in size were visible on the hematoxylin and eosin smears. (cdc.gov)

Meanwhile, at the DMR level, the researchers found more than 10,000 hypo-DMRs between the two esophageal cancer types and also note that many of the methylation changes there were also present in normal cells. (genomeweb.com)
If he could manipulate such a fundamental process to encourage MET and the formation of stem cells, Ding reasoned, such a method would be both safer and more direct than hijacking other aspects of biology, for example those directly involved in cancer. (x-journals.com)
Shende, P. Role of liposome-based stem cells for multimodal cancer therapy. (benthamscience.com)
The PhysiCell model was modified by introducing heterogeneity on cell division in addition to the introduction of cancer stem cells as a new type of cells. (europa.eu)
Interaction of nanoparticles and cancer cells was simulated and analysed using the STEPS model, which allowed for the consideration of spatial heterogeneity of cells. (europa.eu)
Your cancer care team will work with you to choose the best treatment plan based on the type of cancer you have, its location and your physical condition. (sutterhealth.org)
Your cancer care team will work with you to choose the right treatment method based on your cancer type and health situation. (sutterhealth.org)
A beam or beams of high-energy X-rays generated by a linear accelerator are delivered to the tumor, killing the cancer cells. (sutterhealth.org)
The technologies listed below help focus the treatment precisely where it's needed, targeting cancer cells while sparing the surrounding normal tissue. (sutterhealth.org)
While the results need to be confirmed, they suggest that precision metastatic cancer treatments could be chosen based on a single tumor sample. (nih.gov)
Lung cancer cells invading surrounding tissues and starting to spread. (nih.gov)
This approach kills cancer cells while minimizing damage to normal cells. (nih.gov)
However, cancer cells can spread from the place where they first formed to other parts of the body. (nih.gov)
Cancer cells mutate quickly, which helps them adapt and survive. (nih.gov)
They collected and analyzed tissue samples taken from 20 people with newly diagnosed metastatic cancer. (nih.gov)
Increased knowledge of how T cells function will lead to improved cancer therapies and immunotherapies. (edu.au)
The National Cancer Institute's Precision Medicine Initiative has opened the door to exciting new research and therapies that already are expanding options and personalizing treatment for people with cancer. (sutterhealth.org)
From cancer to Alzheimer's disease, many life-threatening diseases can only be treated using drug-based treatment options, if at all. (sciencedaily.com)
These therapies offer new possibilities for treating a wide range of severe diseases, from cancer to Parkinson's disease and diabetes. (lu.se)
Our goal is to advance our ability to treat cancer using cell-based immunotherapy. (lu.se)

Use this form to propose a name for biological substances to be included in products regulated under the Biologicals Framework, i.e. human and living animal cells and tissues. (tga.gov.au)
The Biologicals Framework covers blood, blood components, tissue & cellular products, tissue & cell based derivatives and other emerging biological therapies. (tga.gov.au)
The technology can mimic cartilage's natural mechanical properties, and it can be bioprinted to engineer 3D structures with cells along gradients and more complex biological cues. (corning.com)
ideally, the scaffold eventually is replaced by biological tissue. (corning.com)
Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. (routledge.com)
Mitochondria not only serve as power plants in cells but also act as crucial regulators in many biological processes, including reactive oxygen species (ROS) signaling, redox balance, calcium homeostasis, protein quality control, and programmed cell death ( 3 , 4 ). (frontiersin.org)
Given the complexity of the biological function of mitochondria, researchers have begun to consider rescuing the injured cells through mitochondrial transfer, that is, replacing damaged mitochondria with healthy mitochondria from donor cells. (frontiersin.org)
Further, given their applications in the biomedical field, understanding how biological systems interact with this nanomaterial is urgently needed to create safer therapies, and to regulate occupational exposures. (cdc.gov)

Research into potential treatments includes stem cell implantation, hypothermia, engineered materials for tissue support, epidural spinal stimulation, and wearable robotic exoskeletons. (wikipedia.org)
Not only do they provide long-lasting effects after single treatments, but they also reduce side effects as they are designed to target specific cells or tissues. (ispe.org)
CCMI is part of an established supply chain for ATMP products and has delivered several clinical programs aimed at offering patients alternative treatments through advanced therapies. (ispe.org)
This may prevent the inconvenience of returning for radiation therapy treatments following surgery. (sutterhealth.org)

The scaffold is populated with stem cells from the patient's own abdominal fat and placed inside a bioreactor, which mimics the finely calibrated conditions within the human body, enabling the bone to grow. (prweb.com)

The authors described seroconversion of antinuclear antibodies in two patients with the longest follow-up, "indicating that abrogation of autoimmune B-cell clones may lead to a more widespread correction of autoimmunity," the researchers write. (medscape.com)

He decided he would focus his efforts on manipulating a naturally occurring process in cells, in particular in a type of adult cell called fibroblasts, which give rise to connective tissue. (x-journals.com)
Inflammatory macrophages in the dog contain high amounts of intravesicular ferritin and are associated with pouches of connective tissue fibers. (cdc.gov)

This is then fed into a microfabrication device to carve a piece of pig or cattle bone matrix into the same shape, creating a scaffold for the new bone tissue to grow in. (prweb.com)

In another case study published in June, researchers used CD-19 targeted CAR-T cells to treat a 41-year-old man with refractory antisynthetase syndrome with progressive myositis and interstitial lung disease. (medscape.com)
an open lung biopsy was performed, which revealed constrictive bronchiolitis (the histopathologic correlate of obliterative bronchiolitis) with both narrowed and obliterated airways with surrounding fibrous tissue and a variable mixed chronic inflammatory cell infiltrate. (cdc.gov)
The hope of most researchers in the field is that one day it will be possible to use stem cells - which possess the ability to develop into many other distinct cell types, such as nerve, heart, or lung cells - to repair damaged tissue from any number of diseases, from Type 1 diabetes to Parkinson's disease, as well as from injuries. (x-journals.com)
When used to treat body tumors in the lung, liver, prostate and spine, SRS is called stereotactic body radiation therapy (SBRT). (sutterhealth.org)
Computed tomography (CT) of the chest revealed ground glass opacifications at bases, tree-in-bud nodularity within posterior, lateral, and anterior right upper lobes, and a central necrotic nodule at the left lower lung base measuring 1.3 × 2.1 cm ( Appendix Figure). (cdc.gov)

Because bone tissue is constantly renewing itself, the animal scaffold will eventually be replaced with the patient's own bone. (prweb.com)
The fundamental concept combines various tissue engineering elements, most often a scaffold as a supporting matrix in combination with living cells and/or bioactive molecules, to form a tissue engineering construct that repairs or regenerates the diseased or damaged tissue or organ. (edu.au)

Immunotherapy involves harnessing the body's immune system or T cells to combat the disease by directly killing the infected cells. (edu.au)
The immune system has a remarkable capacity to scan tissues to recognize and eliminate abnormal and malignant cells. (lu.se)

as a result, it is hoped that genetically produced and modified mediators will be able to selectively target diseased cells, and improve the way treatment is delivered. (sciencedaily.com)

June and his research team led the development of CAR T-cell therapies for blood cancers. (medscape.com)
Prior to joining Sartorius, in 2001, he began his involvement with the identification and development of integrated automated systems in cell culture, protein purification and vial filling including the Ambr® products. (b3cnewswire.com)
The research makes great strides in addressing a major practical challenge in the development of stem-cell-based medicine. (x-journals.com)
In addition to its significant practical advantages, the development of the technique deepens the understanding of the biology behind the transformation of adult human cells into stem cells. (x-journals.com)
Methods: This article focuses on recent research development that addresses the viability issues of stem cells. (benthamscience.com)
Lack of proper federal policies that define what can be funded in embryo-based stem cell research or therapy development may restrain the market's expansion in the future to a certain extent. (marketsandmarkets.com)
16 Although induced pluripotent stem cell (iPSC) technology can be used to investigate human astrocyte development and function, only a limited number of studies have described homogeneous generation of healthy astrocytes. (nature.com)
This program supports research that will accelerate the discovery and development of therapies to restore cystic fibrosis transmembrane conductance regulator (CFTR) function in all patients with cystic fibrosis. (cff.org)
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
This presentation describes the current state of the stem cells marketplace as it relates to their utilization for pharmaceutical screening as well as their development for cellular therapy. (selectbiosciences.com)
These courses cover the entire spectrum of advanced therapy development, from initial research to clinical application. (lu.se)

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)
The BRTX-100 production process utilizes proprietary technology and involves collecting a patient's bone marrow, isolating and culturing stem cells from the bone marrow and cryopreserving the cells. (biospace.com)
Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)

Stem cells differentiate into different types of cells, such as neural, hematopoietic, adipose, etc. and are used for the treatment of various conditions like myocardial infarction, spinal cord injury, Parkinson's disease and diabetes. (benthamscience.com)

Stem cells collected from human corneas restore transparency and don't trigger a rejection response when injected into eyes that are scarred and hazy, according to experiments conducted in mice by researchers at the University of Pittsburgh School of Medicine. (news-medical.net)
Cell therapy is a therapy where cellular material is injected systemically or directly into the injured tissue, to promote local repair or to restore systemic health. (bvsalud.org)

The results suggest that a single tumor tissue sample from an individual could be used to guide precision treatment. (nih.gov)
Biomarkers are part of the tumor cells and their levels in the tumor tissue may have a relationship with treatment response. (froedtert.com)

The facility has: 1) setups for biophysical measurements at isolated heart, isolated muscle, and single cell levels (mechanics and intracellular calcium transients), 2) a cell-culture room (incubator, laminar flow hood, centrifuge, microscope), and 3) a wet lab which has equipment necessary to do protein biochemistry and molecular biology research. (pitt.edu)
Dicerna's RNAi technology platform enables access to intracellular disease targets across hepatic and extrahepatic cell and tissue types. (novonordisk.com)

Astroglia are highly heterogeneous neural cells primarily responsible for homeostasis and neuroprotection in the CNS. (nature.com)

The findings suggest that cell-based therapies might be an effective way to treat human corneal blindness and vision impairment due to the scarring that occurs after infection, trauma and other common eye problems, said senior investigator James L. Funderburgh, Ph.D., associate professor, Department of Ophthalmology. (news-medical.net)

Stem Cell Rev. Rep. , 2019 , 16 (1), 103-117. (benthamscience.com)
To ensure all people with CF have access to effective CFTR-directed therapies, the Cystic Fibrosis Foundation announced the Path to a Cure (PTAC) initiative in 2019. (cff.org)
In 2019, Novo Nordisk entered a research collaboration with Dicerna to discover and develop RNAi therapies using Dicerna's proprietary GalXC™ RNAi platform technology. (novonordisk.com)

AD-MSC were isolated by collagenase treatment from adipose tissue from healthy individuals subjected to abdominal lipectomy surgery. (karger.com)
Gene and cell therapies have the potential to revolutionize the treatment of incurable diseases that are often debilitating, if not fatal. (labmanager.com)
Our experiments indicate that after stem cell treatment, mouse eyes that initially had corneal defects looked no different than mouse eyes that had never been damaged," Dr. Funderburgh said. (news-medical.net)
So mitochondria-targeted therapy is suggested to be a potential treatment strategy for cardiovascular diseases. (frontiersin.org)
All tissue samples were taken before any treatment was given. (nih.gov)
Objectives: To evaluate the benefits and harms of stem cell-based interventions for prevention or treatment of GM-IVH and EoP in preterm infants. (lu.se)

Additional characterization using single-cell imaging and dynamic glucose stimulation assays revealed similarities but also notable differences between S7 insulin-secreting cells and primary human beta cells. (nih.gov)
In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
But three months after the lumican-deficient mouse eyes were injected with human adult corneal stem cells, transparency was restored. (news-medical.net)
Several kinds of experiments indicated that the human cells were alive and making lumican, and that the tissue had rebuilt properly," Dr. Funderburgh noted. (news-medical.net)
This is the first example in human cells of how reprogramming speed can be accelerated. (x-journals.com)
The creation of human iPS cells was first announced in December 2007 by two labs, one in Japan and another in Wisconsin. (x-journals.com)

If you have a patient with myositis, for example, where autoreactive B cells are sitting in the inflamed muscle, or a patient with rheumatoid arthritis , where you have disease-relevant B cells in hard-to-reach tissues like the synovium, those cells are much harder to deplete with an antibody, compared to a T cell that evolved to surveil and effectively kill in all tissues," he explained. (medscape.com)
Once B cells are depleted, disease symptoms improve. (medscape.com)
The ability to grow millions of the cells in the lab could make it possible to create an off-the-shelf product, which would be especially useful in countries that have limited medical and surgical resources but a great burden of eye disease due to infections and trauma. (news-medical.net)
Therefore, effective therapies for antifibrosis are vital to improve disease prognosis and reduce healthcare expenditure [ 6 ]. (hindawi.com)
Teixeira, A.L. Stem cells in animal models of Huntington disease: A systematic review. (benthamscience.com)
Since iNKT cell activation can prevent or promote immunopathology in diverse disease contexts, the strict control of peripheral iNKT cell homeostasis is vital to regulate local immunity. (elifesciences.org)
1 , 2 In addition, astroglial cells are endowed with an evolutionary conserved defensive programme known as reactive gliosis, which develops in response to CNS lesions and is manifested by a spectrum of disease-specific cellular responses including hypertrophy and upregulation of intermediate filaments. (nature.com)
In this study, we want to see if tumor based biomarkers have a connection to disease response with anti-estrogen therapy. (froedtert.com)
Cell Therapy for Parkinsons Disease: What Next? (lu.se)

We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial infarction (MI) mice and neonatal rat cardiac fibroblasts treated with angiotensin II (Ang II) or transforming growth factor- β (TGF- β ). (hindawi.com)
Zhang, Y. Integrin β1 increases stem cell survival and cardiac function after myocardial infarction. (benthamscience.com)

Anatomy1

Diseases5

Information Science1

Spinal Cord Injuries

Spinal Cord

Quadriplegia

Encyclopedias as Topic

Paraplegia

Pressure Ulcer

Spinal Cord Diseases

Institute for Bioengineering of Catalonia

Spinal cord injury

Pfizer

Spinal cord injury research

Ozone therapy

Cell bank

Food and Drug Administration

3H Biomedical

Cell encapsulation

Regenerative medicine

Neural Regeneration Research

Alternating electric field therapy

Cell therapy

Allogeneic processed thymus tissue

Tissue engineering of heart valves

Photoimmunotherapy

Cell-based therapies for Parkinson's disease

W. Mark Saltzman

Ali Khademhosseini

Epidermal growth factor

Ethan M. Shevach

Bioceramic

Stephen J. Lippard

ISM radio band

Gene delivery

Photothermal therapy

BioBridge Global

Glassy cell carcinoma of the cervix

Molecular pathological epidemiology

January-March 2022 in science

Developments in clinical cell therapy

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

Introduction to FDA Review and Approval of Biological Products

Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic...

Cells | Free Full-Text | Processing and Ex Vivo Expansion of Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells for the...

Institute for Bioengineering of Catalonia - Wikipedia

Are Cellular Therapies the Future of Autoimmune Disease?

OTP Learn | FDA

Portal Regional da BVS

Richard Wales, Ph.D., and Neil Bargh of Sartorius Honored as Recipients of 2022 ESACT Innovation Award for the Development of...

Rehabilitation Management of Neuromuscular Disease: Overview, Clinical Characteristics of Neuromuscular Disease, Management of...

Proposal for a new Approved Cell & Tissue Name (ACN) application form | Therapeutic Goods Administration (TGA)

Seven Ways Osmolality Testing Improves Cell, Gene Therapy Process Development and Manufacturing | Lab Manager

Stem cell therapy in the management of shoulder rotator cuff disorders

Honoring a Pioneer in Tissue Engineering: Gordana Vunjak-Novakovic Named European Inventor Award 2021 Finalist

Analysis of Methylation in Esophageal Tumors, Nonmalignant Tissue | GenomeWeb

Stem cell therapy used to restore transparency in corneas

Sebastian Kress | Advanced Therapies

Degenerative disc disease: Causes and treatment

Tri-State At a Glance - TriState Health

Obliterative Bronchiolitis in Workers in a Coffee-Processing Facility - Texas, 2008-2012

miR-409-3p Regulated by GATA2 Promotes Cardiac Fibrosis through Targeting Gpd1

A Major Step in Making Better Stem Cells from Adult Tissue - Journals Information

The Future of Joint Replacement Is Tissue Engineering | 3D Cell Culture | Corning

Current Trend and Pro-survival Approaches for Augmenting Stem Cell Viability | Bentham Science

Tuning T cell traits and functions with biomechanical materials | ScienceDaily

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells | eLife

Stem Cell Therapy Market Size, Share, Trends and Revenue Forecast [Latest]

Evolvable platform for programmable nanoparticle-based cancer therapies | EVO-NANO | Project | News & Multimedia | H2020 |...

Graphene scaffolds in progressive nanotechnology/stem cell-based tissue engineering of the nervous system - Journal of...

Regenerative Medicine11

Mesenchymal11

Therapeutic20

Embryonic13

Progenitor cells4

Genes5

20222

Transplantation8

Cellular Therapies4

Organs8

MSCs5

Differentiation4

Stromal3