A species of PESTIVIRUS causing a congenital sheep disease characterized by an abnormally hairy birth-coat, tremors, and poor growth.
Congenital disorder of lambs caused by a virus closely related to or identical with certain strains of bovine viral diarrhea virus.
A genus of ruminants in the family Bovidae. The common name chamois usually refers to the species Rupicapra rupicapra. Rupicapra pyrenaica, found in the Pyrenees, is more properly referred to as the Pyrenean chamois.
A genus of FLAVIVIRIDAE, also known as mucosal disease virus group, which is not arthropod-borne. Transmission is by direct and indirect contact, and by transplacental and congenital transmission. Species include BORDER DISEASE VIRUS, bovine viral diarrhea virus (DIARRHEA VIRUS, BOVINE VIRAL), and CLASSICAL SWINE FEVER VIRUS.
A group of viruses in the genus PESTIVIRUS, causing diarrhea, fever, oral ulcerations, hemorrhagic syndrome, and various necrotic lesions among cattle and other domestic animals. The two species (genotypes), BVDV-1 and BVDV-2 , exhibit antigenic and pathological differences. The historical designation, BVDV, consisted of both (then unrecognized) genotypes.
A species of the PESTIVIRUS genus causing exceedingly contagious and fatal hemorrhagic disease of swine.
The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The type species of APHTHOVIRUS, causing FOOT-AND-MOUTH DISEASE in cloven-hoofed animals. Several different serotypes exist.
A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.
Infections with viruses of the genus PESTIVIRUS, family FLAVIVIRIDAE.
Diseases of domestic and mountain sheep of the genus Ovis.
A species of AVIBIRNAVIRUS causing severe inflammation of the bursa of Fabricius in chickens and other fowl. Transmission is thought to be through contaminated feed or water. Vaccines have been used with varying degrees of success.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Acute disease of cattle caused by the bovine viral diarrhea viruses (DIARRHEA VIRUSES, BOVINE VIRAL). Often mouth ulcerations are the only sign but fever, diarrhea, drop in milk yield, and loss of appetite are also seen. Severity of clinical disease varies and is strain dependent. Outbreaks are characterized by low morbidity and high mortality.
A genus of the family PICORNAVIRIDAE infecting mainly cloven-hoofed animals. They cause vesicular lesions and upper respiratory tract infections. FOOT AND MOUTH DISEASE VIRUS is the type species.
Foot-and-Mouth Disease (FMD) is a highly contagious and severe viral disease in cloven-hoofed animals, characterized by fever, formation of vesicles and erosions in the mouth, on the tongue, lips, teats, and feet, causing significant economic losses in agriculture and livestock farming.

Nested reverse transcriptase-polymerase chain reaction (RT-PCR) for typing ruminant pestiviruses: bovine viral diarrhea viruses and border disease virus. (1/23)

A nested reverse transcription (RT) polymerase chain reaction (PCR) assay was evaluated for differentiating reference bovine viral diarrhea virus (BVDV) strains, BVDV from diagnostic accessions, modified-live virus (MLV) BVDV strains in bovine viral vaccines, and a reference border disease virus (BDV). The detection level of this assay was compared to viral infection in cell culture. The PCR assay was used to distinguish 3 ruminant pestiviruses, types 1 and 2 BVDV, and type 3 BDV. The consensus (first) PCR assay detected all 3 ruminant pestiviruses, a result of the shared sequence homology. The consensus PCR product was subjected to a second (nested) PCR which used type-specific primers. The nested PCR was able to differentiate the 3 ruminant pestiviruses. Viral stocks of BVDV were diluted 10-fold and processed for the 2-step PCR assay. The sensitivity of this 2-step PCR assay was compared to viral infectivity in cell culture based on identical volumes of the system tested (cell culture assay and processing for RNA). The RT-PCR type-specific assay differentiated BVDV laboratory reference strains (12), diagnostic laboratory isolates (15), 2 MLV BVDV vaccine strains, and a BDV strain. The 30 ruminant pestiviruses typed included: (1) 27 reference strains and diagnostic laboratory isolates; 18 cytopathic (CP) type 1 strains, 3 CP type 2 strains, 3 noncytopathic (NCP) type 1 strains, and 3 NCP type 2 strains; (2) 2 MLV strains, type 1; and (3) 1 CP BDV type 3. The PCR assay had a detection limit of 10 TCID50/0.025 mL of virus when 3 separate BVDV were tested. This 2 step RT-PCR assay would be useful for the typing of ruminant pestiviruses, particularly BVDV isolates from the diagnostic laboratory.  (+info)

A RT-PCR assay for the rapid recognition of border disease virus. (2/23)

A reverse transcription--polymerase chain reaction (RT-PCR) method was developed for the specific detection of border disease virus (BDV), using the primers PBD1 and PBD2 flanking a 225 bp DNA fragment, selected from the 5'noncoding region of the pestivirus genome. In tests on 70 pestiviruses it was shown to be BDV-specific. A closed, one-tube nested RT-PCR method employing general pestivirus outer primers (324 and 326), and the same BDV-specific inner primers (PBD1 and PBD2) in conjunction with a BDV-specific fluorogenic TaqMan probe also detected only BDV and was more sensitive. BDV-specific RT-PCR was used in combination with a PCR specific for bovine viral diarrhoea virus type 2 (BVDV2) to ascertain whether virus stocks contained mixtures of BDV and BVDV2. It was shown that the ovine pestivirus strains 175375 and 59386 were originally BDV, but after subculture had become contaminated with BVDV2. This explains a previously reported discrepancy in the genetic typing of 59386. Although the BDV-specific RT-PCR can also detect BDV in clinical samples, the assay is likely to be most useful for the rapid typing of laboratory pestivirus strains.  (+info)

Experimental model of Border Disease Virus infection in lambs: comparative pathogenicity of pestiviruses isolated in France and Tunisia. (3/23)

Pestiviruses have been isolated from live sheep pox Tunisian vaccines. Vaccination with these vaccines caused outbreaks of Border Disease in Tunisia. In order to study more precisely the pathogenicity of these isolates, three groups of eight four month old lambs from a pestivirus-free flock were infected by the intratracheal route with a French strain (AV) and two Tunisian isolates (SN3G and Lot21). Clinical, hematological, immunological and virological parameters were evaluated. The three groups developed mild fever and leucopaenia by day 3 to 6 post infection (pi). The differences in the weight curves were not significant. Viruses were isolated from the peripheral blood buffy coat cells by day 4 to 9 pi. Antibodies were present on day 16 pi following infection by the French strain and on day 21 pi with the Tunisian isolates. The results demonstrated that SN3G and Lot21 are almost similar to the French strain used as the reference strain. In field conditions, they could induce economical losses in naive flocks, alone or in association with other pathogens.  (+info)

The envelope glycoprotein E2 is a determinant of cell culture tropism in ruminant pestiviruses. (4/23)

Bovine viral diarrhoea virus (BVDV) isolates infect cultured Madin-Darby bovine kidney (MDBK) cells as efficiently as sheep kidney cells. In contrast, border disease virus (BDV) propagates poorly in MDBK cells but infects sheep cells very efficiently. The envelope glycoprotein E2 has been shown to be essential for virus infectivity. To explore the potential role of E2 in pestivirus host range in cell cultures, we engineered a chimeric BVDV with the E2 coding region from BDV. As expected, the BVDV-E2(bdv) chimera retained the ability of BDV to multiply in sheep cells but experienced a remarkable reduction in its ability to propagate and form plaques in MDBK, a phenotype that is characteristic of the E2 donor, BDV31 virus. Control chimeric BVDV bearing a type II E2 demonstrated that the heterologous E2 does not impair replication in MDBK or lamb cells. These results establish a role for E2 in determining the tropism of a pestivirus in cell culture.  (+info)

Virulence, immunogenicity and vaccine properties of a novel chimeric pestivirus. (5/23)

A chimeric pestivirus of border disease virus Gifhorn and bovine viral diarrhea virus CP7 (Meyers et al., 1996) was constructed. Virulence, immunogenicity and vaccine properties of the chimeric virus were studied in a vaccination-challenge experiment in pigs. The chimeric virus proved to be avirulent and neither chimeric virus nor viral RNA was detected in serum after vaccination. The safety of the vaccine was tested by horizontal transmission to sentinel pigs, which remained uninfected. The vaccine efficacy was examined by challenge infection with classical swine fever virus (CSFV) Eystrup. In 'challenge controls', the viral load of CSFV coincided with the development of pronounced clinical symptoms. In contrast, the vaccinated pigs showed transient and weak clinical signs. Analysis of the viral load in these pigs showed 1000-fold lower viral RNA levels compared to 'challenge controls' and horizontal transmission of challenge virus to sentinel pigs was not observed.  (+info)

Chimeric pestiviruses: candidates for live-attenuated classical swine fever marker vaccines. (6/23)

The use of attenuated classical swine fever virus (CSFV) strains as live vaccines is no longer allowed for the control of classical swine fever in Europe, due to the inability to differentiate between infected and vaccinated animals (Differentiating Infected from Vaccinated Animals; DIVA), except as emergency vaccines or as bait vaccines for wild boars. Thus, the establishment of a DIVA vaccine(s) is of pivotal importance for the control of this infectious disease. In this study, recombinant versions of the live-attenuated vaccine strain CSFV Riems were generated by replacing parts of the E2 gene with the corresponding sequence of border disease virus strain Gifhorn. Three cDNA clones were constructed: pRiems-ABC-Gif, pRiems-A-Gif and pRiems-BC-Gif. Infectious particles were obtained from clones pRiems-ABC-Gif and pRiems-BC-Gif only, whereas transfected RNA from clone pRiems-A-Gif behaved like a replicon. Based on its ability to be differentiated in vitro from wild-type CSFV by mAbs, vRiems-ABC-Gif was assessed for immunogenicity and protection against challenge infection in pigs. Before challenge, no CSFV-specific anti-E2 antibodies could be detected with commercial E2-blocking ELISAs in vRiems-ABC-Gif-vaccinated animals, whereas vRiems-vaccinated pigs developed high titres of anti-E2 antibodies, confirming the marker properties of this vaccine candidate. After oral vaccination, only partial protection against challenge infection was observed in the vRiems-ABC-Gif vaccinees, whereas all intramuscularly vaccinated animals and all vRiems-vaccinated animals were fully protected. These experiments suggest that the strategy of exchanging specific antigenic epitopes among pestiviruses is a promising tool for the development of new CSFV marker vaccines.  (+info)

Border disease virus among chamois, Spain. (7/23)

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Detection of Border disease virus in fetuses, stillbirths, and newborn lambs from natural and experimental infections. (8/23)

The purpose of the present study was to evaluate the use of enzyme-linked immunosorbent assay (ELISA) antigen detection in blood or fetal fluids and reverse transcription polymerase chain reaction (RT-PCR) amplification in tissues for routine laboratory diagnosis of Border disease virus (BDV) infection. Samples from 67 fetuses, 6 stillbirths, and 11 lambs from 25 commercial flocks with suspicion of BDV abortion and 3 fetuses, 7 stillbirths, and 15 lambs obtained from an experimental infection with a local isolate (BDV genotype 4) were investigated. Presence of BDV was detected by RT-PCR in 7.9% of fetuses, 50% of stillbirths, and 50% of lambs from the commercial flocks analyzed, corresponding to 8 of the 25 farms (32%). A similar percentage of the lambs and stillbirths from the experimental infection were positive by RT-PCR of tissue samples (54.5%), and the highest positivity was detected in lymph node, thyroid gland, and kidney. The current study revealed that RT-PCR analysis of stillbirths and lambs with clinical symptoms is more suitable than the analysis of fetuses to confirm the presence of BDV in a flock. Pestiviral antigen was detected by antigen ELISA in a high proportion of fetuses (24/58) and stillbirths (3/4) from commercial flocks, but in lambs, the presence of colostral antibodies masked the detection of the antigen by ELISA. Nevertheless, in lambs from the experimental infection that were not fed colostrum, antigen ELISA was less efficient than RT-PCR in detecting viral presence in stillbirths and lambs. Antigen ELISA is therefore recommended for fetuses with advanced autolysis that can adversely affect RNA integrity.  (+info)

Border Disease Virus (BDV) is a member of the genus Pestivirus within the family Flaviviridae. It is a viral pathogen that primarily affects sheep and goats, causing a disease known as Border Disease in these animals. The virus is named after the geographical location where it was first identified, the border region between England and Scotland.

BDV is a small, enveloped, single-stranded RNA virus that can cause a range of clinical signs in infected sheep and goats, including abortion, stillbirths, congenital defects, and poor growth rates in newborn lambs or kids. The virus is transmitted horizontally through direct contact with infected animals, their bodily fluids, or contaminated objects. Vertical transmission from ewes to their offspring can also occur, resulting in the birth of persistently infected (PI) lambs that serve as a significant source of infection within flocks.

Infection with BDV can lead to economic losses for farmers due to reduced productivity and increased mortality rates. There is no specific treatment for Border Disease, but vaccination programs can help control the spread of the virus in sheep and goat populations.

Border Disease is a viral infection that affects sheep and goats, primarily causing reproductive issues. The causative agent is the Border Disease Virus (BDV), which belongs to the family *Pestiviridae*. The disease is named after the Border region of England and Scotland where it was first identified.

The infection in pregnant ewes can lead to a range of outcomes, including abortion, stillbirth, or the birth of live lambs with congenital defects. These lambs, often called "hairy shakers," may exhibit symptoms such as tremors, hairy coat, small size, and abnormalities in their ears and hooves. They may also have a weakened immune system, making them more susceptible to other infections.

The BDV is primarily transmitted through contact with infected placenta, fetal fluids, or secretions from infected animals. It can also be spread through contaminated needles or equipment. While there is no specific treatment for Border Disease, good biosecurity practices and vaccination of ewes can help prevent its spread.

"Rupicapra" is not a medical term, but a genus name for a group of wild caprine animals, also known as wild goats. The two living species are the Western Rupicapra (Rupicapra rupicapra) and the Eastern Rupicapra (Rupicapra pyrenaica). They are native to mountainous regions in Europe and Asia.

In a medical context, "rupicapra" may appear in rare cases as part of a scientific name for a disease or condition that is named after the animal, but I couldn't find any specific examples of this usage.

Pestivirus is a genus of viruses in the family Flaviviridae, which are enveloped, single-stranded, positive-sense RNA viruses. There are several species within this genus that can cause disease in animals, including bovine viral diarrhea virus (BVDV) in cattle, border disease virus (BDV) in sheep, and classical swine fever virus (CSFV) in pigs. These viruses can cause a range of clinical signs, including respiratory and enteric diseases, reproductive failures, and immunosuppression. They are primarily spread through direct contact with infected animals or their bodily fluids, and can also be transmitted through contaminated fomites and semen. Prevention and control measures include vaccination, biosecurity practices, and testing and culling of infected animals.

Bovine viral diarrhea (BVD) is a viral disease that primarily affects cattle, but can also infect other ruminants such as sheep and goats. The disease is caused by the bovine viral diarrhea virus (BVDV), which belongs to the family Flaviviridae and genus Pestivirus.

There are two biotypes of BVDV, type 1 and type 2, which can be further divided into various subtypes based on their genetic makeup. The virus can cause a range of clinical signs in infected animals, depending on the age and immune status of the animal, as well as the strain of the virus.

Acute infection with BVDV can cause fever, lethargy, loss of appetite, nasal discharge, and diarrhea, which can be severe and life-threatening in young calves. In addition, BVDV can cause reproductive problems such as abortion, stillbirth, and the birth of persistently infected (PI) calves. PI animals are those that were infected with BVDV in utero and have the virus continuously present in their bloodstream and other tissues throughout their lives. These animals serve as a source of infection for other cattle and can spread the virus to naive herds.

BVDV is transmitted through direct contact with infected animals or their bodily fluids, such as saliva, nasal secretions, and feces. The virus can also be spread indirectly through contaminated feed, water, and equipment. Prevention and control measures for BVDV include biosecurity practices, vaccination, and testing to identify and remove PI animals from herds.

Classical Swine Fever Virus (CSFV) is a positive-stranded RNA virus that belongs to the genus Pestivirus within the family Flaviviridae. It is the causative agent of Classical Swine Fever (CSF), also known as hog cholera, which is a highly contagious and severe disease in pigs. The virus is primarily transmitted through direct contact with infected animals or their body fluids, but it can also be spread through contaminated feed, water, and fomites.

CSFV infects pigs of all ages, causing a range of clinical signs that may include fever, loss of appetite, lethargy, weakness, diarrhea, vomiting, and respiratory distress. In severe cases, the virus can cause hemorrhages in various organs, leading to high mortality rates. CSF is a significant disease of economic importance in the swine industry, as it can result in substantial production losses and trade restrictions.

Prevention and control measures for CSF include vaccination, biosecurity practices, and stamping-out policies. Vaccines against CSF are available but may not provide complete protection or prevent the virus from shedding, making it essential to maintain strict biosecurity measures in pig farms. In some countries, stamping-out policies involve the rapid detection and elimination of infected herds to prevent the spread of the disease.

Newcastle disease virus (NDV) is a single-stranded, negative-sense RNA virus that belongs to the genus Avulavirus in the family Paramyxoviridae. It is the causative agent of Newcastle disease, a highly contagious and often fatal viral infection affecting birds and poultry worldwide. The virus can cause various clinical signs, including respiratory distress, neurological disorders, and decreased egg production, depending on the strain's virulence. NDV has zoonotic potential, but human infections are rare and typically result in mild, flu-like symptoms.

I apologize, but "sheep" is not a term that has a medical definition. It is a common animal with the scientific name Ovis aries. If you have any medical or health-related questions, I would be happy to try and help answer those for you.

Foot-and-Mouth Disease Virus (FMDV) is a single-stranded, positive-sense RNA virus belonging to the family Picornaviridae and the genus Aphthovirus. It is the causative agent of Foot-and-Mouth Disease (FMD), a highly contagious and severe viral disease that affects cloven-hoofed animals, including cattle, swine, sheep, goats, and buffalo. The virus can be transmitted through direct contact with infected animals or their bodily fluids, as well as through aerosolized particles in the air. FMDV has seven distinct serotypes (O, A, C, Asia 1, and South African Territories [SAT] 1, 2, and 3), and infection with one serotype does not provide cross-protection against other serotypes. The virus primarily targets the animal's epithelial tissues, causing lesions and blisters in and around the mouth, feet, and mammary glands. FMD is not a direct threat to human health but poses significant economic consequences for the global livestock industry due to its high infectivity and morbidity rates.

Borna Disease Virus (BoDV) is a negative-stranded RNA virus that belongs to the family Bornaviridae. It is the causative agent of Borna disease, a neurological disorder primarily affecting horses and sheep in Europe, although it has also been found in other mammals including cats, dogs, rabbits, and humans.

The virus is named after the town of Borna in Saxony, Germany, where an outbreak of the disease occurred in horses in the late 19th century. BoDV is unique among animal viruses because it can establish a persistent infection in the central nervous system (CNS) of its hosts and has been shown to have neurotropic properties.

In humans, BoDV infection has been linked to cases of encephalitis, a potentially life-threatening inflammation of the brain. However, human infections with BoDV are rare and often associated with close contact with infected animals or their tissues. There is currently no specific treatment for Borna disease or BoDV infection, and prevention efforts focus on reducing exposure to the virus through appropriate handling and care of infected animals.

Pestivirus infections refer to a group of diseases caused by viruses of the genus Pestivirus, which belongs to the family Flaviviridae. There are several different types of Pestiviruses, including bovine viral diarrhea virus 1 and 2 (BVDV-1 and BVDV-2), classical swine fever virus (CSFV), and border disease virus (BDV).

These viruses can cause a range of clinical signs in animals, depending on the species infected, the age and immune status of the animal, and the strain of the virus. In general, Pestivirus infections can cause fever, lethargy, loss of appetite, and various symptoms related to the respiratory, digestive, or reproductive systems.

For example, BVDV-1 and BVDV-2 are important pathogens in cattle and can cause a variety of clinical signs, including respiratory disease, diarrhea, reproductive failure, and immunosuppression. CSFV is a highly contagious virus that affects pigs and can cause fever, loss of appetite, hemorrhages, and neurological symptoms. BDV infects sheep and goats and can cause abortion, stillbirth, and congenital defects in offspring.

Prevention and control measures for Pestivirus infections include vaccination, biosecurity practices, and testing and culling of infected animals.

I'm happy to help, but I want to clarify that the term "sheep diseases" refers to a wide range of health issues that can affect sheep populations. It's not a single medical condition with a specific definition. Here are some examples of common diseases that can affect sheep:

1. Ovine Johne's Disease (OJD): A chronic, infectious disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis. It affects the intestines and can cause weight loss, diarrhea, and death.
2. Footrot: A highly contagious bacterial infection that affects the feet of sheep, causing lameness, swelling, and pain. It's caused by the bacteria Dichelobacter nodosus.
3. Caseous Lymphadenitis (CL): A chronic infectious disease caused by the bacterium Corynebacterium pseudotuberculosis. It affects the lymph nodes and can cause abscesses, weight loss, and death.
4. Contagious Ecthyma (Orf): A highly contagious viral infection that affects the skin and mucous membranes of sheep, causing sores and lesions.
5. Mastitis: An inflammation of the mammary gland in sheep, usually caused by a bacterial infection. It can cause decreased milk production, fever, and loss of appetite.
6. Pneumonia: A respiratory infection that can affect sheep, causing coughing, difficulty breathing, and fever. It can be caused by various bacteria or viruses.
7. Enterotoxemia: A potentially fatal disease caused by the overproduction of toxins in the intestines of sheep, usually due to a bacterial infection with Clostridium perfringens.
8. Polioencephalomalacia (PEM): A neurological disorder that affects the brain of sheep, causing symptoms such as blindness, circling, and seizures. It's often caused by a thiamine deficiency or excessive sulfur intake.
9. Toxoplasmosis: A parasitic infection that can affect sheep, causing abortion, stillbirth, and neurological symptoms.
10. Blue tongue: A viral disease that affects sheep, causing fever, respiratory distress, and mouth ulcers. It's transmitted by insect vectors and is often associated with climate change.

Infectious Bursal Disease Virus (IBDV) is a highly contagious avian virus that primarily affects the bursa of Fabricius in young chickens, leading to an immunosuppressive disease known as Gumboro disease. The bursa of Fabricius is a vital organ for the development and maturation of B cells, which are crucial for the immune system's response to infections.

IBDV is a non-enveloped, double-stranded RNA virus belonging to the Birnaviridae family. It has two serotypes, with serotype 1 being responsible for the majority of outbreaks and being highly pathogenic, while serotype 2 is less virulent and causes mild or asymptomatic infections.

The virus targets and destroys the B cells in the bursa, leading to a weakened immune system that makes the affected chickens more susceptible to secondary bacterial and viral infections. The disease can cause significant economic losses in the poultry industry due to high mortality rates, decreased feed conversion efficiency, and reduced egg production.

Vaccination is an effective prevention strategy against IBDV, with both live and inactivated vaccines available for use in chickens. Good biosecurity measures, such as strict sanitation practices and limiting the movement of birds and people between farms, can also help prevent the spread of the virus.

"Cattle" is a term used in the agricultural and veterinary fields to refer to domesticated animals of the genus *Bos*, primarily *Bos taurus* (European cattle) and *Bos indicus* (Zebu). These animals are often raised for meat, milk, leather, and labor. They are also known as bovines or cows (for females), bulls (intact males), and steers/bullocks (castrated males). However, in a strict medical definition, "cattle" does not apply to humans or other animals.

Bovine Virus Diarrhea-Mucosal Disease (BVD-MD) is a complex of diseases caused by the Bovine Virus Diarrhea virus (BVDV) and is a significant problem in the global cattle industry. The disease can manifest in various forms, from mild respiratory or reproductive issues to severe, life-threatening conditions such as mucosal disease.

Mucosal disease is the most acute form of BVD-MD and occurs when an animal that has been persistently infected (PI) with a specific strain of BVDV develops a secondary infection with a cytopathic biotype of the virus. PI animals are those that were infected in utero with BVDV before they developed immune competence, resulting in them shedding large amounts of the virus throughout their lives.

The secondary infection with the cytopathic biotype of BVDV causes extensive damage to the animal's lymphoid tissues and gastrointestinal tract, leading to severe clinical signs such as:

1. Profuse diarrhea
2. High fever (up to 41°C or 105.8°F)
3. Ulcerative lesions in the mouth, esophagus, and intestines
4. Severe dehydration
5. Depression and loss of appetite
6. Weight loss
7. Weakness
8. Increased respiratory rate
9. Swelling of the head, neck, and brisket
10. Death within 2-3 weeks after the onset of clinical signs

Morbidity and mortality rates in BVD-MD outbreaks can be high, causing significant economic losses for farmers due to decreased production, increased veterinary costs, and animal deaths. Prevention strategies include vaccination programs, biosecurity measures, and testing for PI animals to remove them from the herd.

Aphthovirus is a genus of viruses in the family Picornaviridae, order Picornavirales. This genus includes several species of viruses that are primarily associated with causing oral and foot lesions in cloven-hoofed animals, such as cattle, sheep, and pigs. The most well-known member of this genus is foot-and-mouth disease virus (FMDV), which causes a highly contagious and economically significant disease in livestock. Other species in the Aphthovirus genus include equine rhinitis A virus, bovine rhinitis virus, and porcine teschovirus. These viruses are typically transmitted through direct contact with infected animals or their secretions and excretions, and they can cause a range of clinical signs including fever, loss of appetite, lameness, and lesions in the mouth and feet. There are currently no vaccines available for all serotypes of FMDV, and control measures typically involve quarantine, slaughter of infected animals, and strict biosecurity practices to prevent spread of the virus.

Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals, including cattle, sheep, goats, pigs, and buffalo. The virus can also infect wild animals like deer and antelope. FMD is not a direct threat to human health but may have significant economic impacts due to restrictions on trade and movement of infected animals.

The disease is characterized by fever, blister-like sores (vesicles) in the mouth, on the tongue, lips, gums, teats, and between the hooves. The vesicles can rupture, causing painful erosions that make it difficult for affected animals to eat, drink, or walk. In severe cases, FMD can lead to death, particularly among young animals.

The causative agent of foot-and-mouth disease is the foot-and-mouth disease virus (FMDV), which belongs to the Picornaviridae family and Aphthovirus genus. There are seven serotypes of FMDV: O, A, C, Asia 1, and South African Territories (SAT) 1, SAT 2, and SAT 3. Infection with one serotype does not provide cross-protection against other serotypes.

Prevention and control measures for foot-and-mouth disease include vaccination, quarantine, movement restrictions, disinfection, and culling of infected animals in severe outbreaks. Rapid detection and response are crucial to prevent the spread of FMD within and between countries.

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