Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Research Support as Topic: Financial support of research activities.Biomedical Technology: The application of technology to the solution of medical problems.Laboratory Animal Science: The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.National Institutes of Health (U.S.): An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Animals, LaboratoryBiomedical Engineering: Application of principles and practices of engineering science to biomedical research and health care.Animal Experimentation: The use of animals as investigational subjects.Ethics, Research: The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Research Personnel: Those individuals engaged in research.Translational Medical Research: The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Natural Language Processing: Computer processing of a language with rules that reflect and describe current usage rather than prescribed usage.Biological Specimen Banks: Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.Human Experimentation: The use of humans as investigational subjects.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.Animal Welfare: The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Research Subjects: Persons who are enrolled in research studies or who are otherwise the subjects of research.Data Mining: Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Animal Rights: The moral and ethical bases of the protection of animals from cruelty and abuse. The rights are extended to domestic animals, laboratory animals, and wild animals.United StatesMedical Informatics Computing: Precise procedural mathematical and logical operations utilized in the study of medical information pertaining to health care.Facility Design and Construction: Architecture, exterior and interior design, and construction of facilities other than hospitals, e.g., dental schools, medical schools, ambulatory care clinics, and specified units of health care facilities. The concept also includes architecture, design, and construction of specialized contained, controlled, or closed research environments including those of space labs and stations.Medical Informatics Applications: Automated systems applied to the patient care process including diagnosis, therapy, and systems of communicating medical data within the health care setting.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Education, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Bioethics: A branch of applied ethics that studies the value implications of practices and developments in life sciences, medicine, and health care.Medical Informatics: The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.History, 20th Century: Time period from 1901 through 2000 of the common era.Animal Care Committees: Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).Genetic Research: Research into the cause, transmission, amelioration, elimination, or enhancement of inherited disorders and traits.Semantics: The relationships between symbols and their meanings.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Environmental Pollution: Contamination of the air, bodies of water, or land with substances that are harmful to human health and the environment.Animal Use Alternatives: Alternatives to the use of animals in research, testing, and education. The alternatives may include reduction in the number of animals used, replacement of animals with a non-animal model or with animals of a species lower phylogenetically, or refinement of methods to minimize pain and distress of animals used.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Medical Waste Disposal: Management, removal, and elimination of biologic, infectious, pathologic, and dental waste. The concept includes blood, mucus, tissue removed at surgery or autopsy, soiled surgical dressings, and other materials requiring special control and handling. Disposal may take place where the waste is generated or elsewhere.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Autoexperimentation: Intentionally using oneself as a research subject.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Systems Integration: The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Ethics Committees, Research: Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.Biomedical Enhancement: The use of technology-based interventions to improve functional capacities rather than to treat disease.Information Management: Management of the acquisition, organization, storage, retrieval, and dissemination of information. (From Thesaurus of ERIC Descriptors, 1994)Cooperative Behavior: The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.History, 21st Century: Time period from 2001 through 2100 of the common era.Databases, Bibliographic: Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.Access to Information: Individual's rights to obtain and use information collected or generated by others.Information Dissemination: The circulation or wide dispersal of information.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Nursing Research: Research carried out by nurses, generally in clinical settings, in the areas of clinical practice, evaluation, nursing education, nursing administration, and methodology.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Artificial Intelligence: Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Universities: Educational institutions providing facilities for teaching and research and authorized to grant academic degrees.Tissue Banks: Centers for acquiring, characterizing, and storing organs or tissue for future use.Models, Animal: Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.Guidelines as Topic: A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.Databases as Topic: Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)Science: The study of natural phenomena by observation, measurement, and experimentation.Ethology: The discipline pertaining to the study of animal behavior.Unified Medical Language System: A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.Financing, Government: Federal, state, or local government organized methods of financial assistance.Federal Government: The level of governmental organization and function at the national or country-wide level.Education, Veterinary: Use for general articles concerning veterinary medical education.Confidentiality: The privacy of information and its protection against unauthorized disclosure.Health Services Research: The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)Medical Laboratory Personnel: Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.Awards and PrizesGovernment Agencies: Administrative units of government responsible for policy making and management of governmental activities.Conflict of Interest: A situation in which an individual might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust. The term is not restricted to government officials. The concept refers both to actual conflict of interest and the appearance or perception of conflict.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Moral Obligations: Duties that are based in ETHICS, rather than in law.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.United States Public Health Service: A constituent organization of the DEPARTMENT OF HEALTH AND HUMAN SERVICES concerned with protecting and improving the health of the nation.Societies, Scientific: Societies whose membership is limited to scientists.Genetic Privacy: The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.Information Systems: Integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information.Public Policy: A course or method of action selected, usually by a government, from among alternatives to guide and determine present and future decisions.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Neurosciences: The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Documentation: Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.Medical Subject Headings: Controlled vocabulary thesaurus produced by the NATIONAL LIBRARY OF MEDICINE. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity.Budgets: Detailed financial plans for carrying out specific activities for a certain period of time. They include proposed income and expenditures.Clinical Medicine: The study and practice of medicine by direct examination of the patient.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.Academic Medical Centers: Medical complexes consisting of medical school, hospitals, clinics, libraries, administrative facilities, etc.Disease: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Consumer Participation: Community or individual involvement in the decision-making process.Social Justice: An interactive process whereby members of a community are concerned for the equality and rights of all.Trust: Confidence in or reliance on a person or thing.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Computer Communication Networks: A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)Community-Institutional Relations: The interactions between members of a community and representatives of the institutions within that community.Diagnostic Imaging: Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.Pattern Recognition, Automated: In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)Biostatistics: The application of STATISTICS to biological systems and organisms involving the retrieval or collection, analysis, reduction, and interpretation of qualitative and quantitative data.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Biological Ontologies: Structured vocabularies describing concepts from the fields of biology and relationships between concepts.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Animal Husbandry: The science of breeding, feeding and care of domestic animals; includes housing and nutrition.Professional Review Organizations: Organizations representing designated geographic areas which have contracts under the PRO program to review the medical necessity, appropriateness, quality, and cost-effectiveness of care received by Medicare beneficiaries. Peer Review Improvement Act, PL 97-248, 1982.Public Relations: Relations of an individual, association, organization, hospital, or corporation with the publics which it must take into consideration in carrying out its functions. Publics may include consumers, patients, pressure groups, departments, etc.Housing, AnimalNeoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Online Systems: Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)Government Regulation: Exercise of governmental authority to control conduct.Programming Languages: Specific languages used to prepare computer programs.Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Interdisciplinary Communication: Communication, in the sense of cross-fertilization of ideas, involving two or more academic disciplines (such as the disciplines that comprise the cross-disciplinary field of bioethics, including the health and biological sciences, the humanities, and the social sciences and law). Also includes problems in communication stemming from differences in patterns of language usage in different academic or medical disciplines.Leadership: The function of directing or controlling the actions or attitudes of an individual or group with more or less willing acquiescence of the followers.Information Services: Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)Security Measures: Regulations to assure protection of property and equipment.Abbreviations as Topic: Shortened forms of written words or phrases used for brevity.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Genetics, Medical: A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.Animal Testing Alternatives: Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.History, 19th Century: Time period from 1801 through 1900 of the common era.Schools, Medical: Educational institutions for individuals specializing in the field of medicine.PrimatesDental Research: The study of laws, theories, and hypotheses through a systematic examination of pertinent facts and their interpretation in the field of dentistry. (From Jablonski, Illustrated Dictionary of Dentistry, 1982, p674)Hazardous Waste: Waste products which threaten life, health, or the environment when improperly treated, stored, transported, disposed of, or otherwise managed.Clinical Nursing Research: Research carried out by nurses in the clinical setting and designed to provide information that will help improve patient care. Other professional staff may also participate in the research.Environmental Health: The science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health.Veterinarians: Individuals with a degree in veterinary medicine that provides them with training and qualifications to treat diseases and injuries of animals.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Behavioral Research: Research that involves the application of the behavioral and social sciences to the study of the actions or reactions of persons or animals in response to external or internal stimuli. (from American Heritage Dictionary, 4th ed)Forecasting: The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.Data Interpretation, Statistical: Application of statistical procedures to analyze specific observed or assumed facts from a particular study.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Qualitative Research: Any type of research that employs nonnumeric information to explore individual or group characteristics, producing findings not arrived at by statistical procedures or other quantitative means. (Qualitative Inquiry: A Dictionary of Terms Thousand Oaks, CA: Sage Publications, 1997)Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Education, Medical: Use for general articles concerning medical education.Subject Headings: Terms or expressions which provide the major means of access by subject to the bibliographic unit.Computer Systems: Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities.Community-Based Participatory Research: Collaborative process of research involving researchers and community representatives.Rodent Diseases: Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).Public Opinion: The attitude of a significant portion of a population toward any given proposition, based upon a measurable amount of factual evidence, and involving some degree of reflection, analysis, and reasoning.EuropeIndustry: Any enterprise centered on the processing, assembly, production, or marketing of a line of products, services, commodities, or merchandise, in a particular field often named after its principal product. Examples include the automobile, fishing, music, publishing, insurance, and textile industries.Ethical Review: A formal process of examination of patient care or research proposals for conformity with ethical standards. The review is usually conducted by an organized clinical or research ethics committee (CLINICAL ETHICS COMMITTEES or RESEARCH ETHICS COMMITTEES), sometimes by a subset of such a committee, an ad hoc group, or an individual ethicist (ETHICISTS).Callithrix: A genus of the subfamily CALLITRICHINAE occurring in forests of Brazil and Bolivia and containing seventeen species.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Comprehension: The act or fact of grasping the meaning, nature, or importance of; understanding. (American Heritage Dictionary, 4th ed) Includes understanding by a patient or research subject of information disclosed orally or in writing.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Macaca fascicularis: A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.Equipment Design: Methods of creating machines and devices.Health Policy: Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Genetic Engineering: Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.Data Collection: Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.Protein Interaction Mapping: Methods for determining interaction between PROTEINS.Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Models, Theoretical: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Systems Biology: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.Laboratories: Facilities equipped to carry out investigative procedures.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Program Development: The process of formulating, improving, and expanding educational, managerial, or service-oriented work plans (excluding computer program development).Molecular Sequence Annotation: The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.Conservation of Natural Resources: The protection, preservation, restoration, and rational use of all resources in the total environment.Regenerative Medicine: A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Developing Countries: Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.ComputersProteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Macaca mulatta: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Libraries, MedicalPhenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.

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... is a world-renowned non-profit research institution dedicated to improving human health through basic biomedical research. By ... The annual award is the University of Pittsburgh School of Medicine's highest honor and recognizes "an American biomedical ...
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Examine the company profile of LA Biomedical Research Institute and learn about LA Biomedical Research Institute jobs and ... LA Biomedical Research Institute Jobs & Careers 9 Jobs Found 9 Jobs Found ...
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Home » Commonwealth Biomedical Research Commonwealth Biomedical Research. PPD establishes phase I site network spanning the ...
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... integrates research into the genotypic and phenotypic relationships underpinning our understanding of health, disease and ... Biomedical Research Group (BRG). Biomedical Research Group (BRG). ... Our Biomedical Research Group (BRG) aims to integrate research into the genotypic and phenotypic relationships underpinning our ... We offer our Biomedical Science PhD. We have also identified a range of innovative research project opportunities for you as a ...
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The EuroEspes Biomedical Research Center is a private institution providing cutting-edge medical services for the prevention ... EuroEspes Biomedical Research Center The EuroEspes Biomedical Research Center is a private institution providing cutting-edge ... The EuroEspes Biomedical Research Center is cooperating with the point of giving the best conceivable consideration regarding ... The following is the list of scholars from EuroEspes Biomedical Research Center who contributed and/or serves as editors for ...
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Interest Basic Objectives Basic Research Mission Bastrop behavior beta-mannosidosis biomedical research Breeding and Research ... NCRR Resources for Comparative Biomedical Research Directory. DHHS publication. Contributors. Research Resources Information ... Ph.D physiology Primate Research Center Principal lnvestigator Program Regional Primate Research Research Emphasis Research ... gb-gplus-shareNCRR Resources for Comparative Biomedical Research Directory. ...
*  The Allocation of Publicly Funded Biomedical Research
We calculate distributions of government-funded biomedical research expenditure, by disease, from records of all re-search ... The number of research grants mentioning a chronic condition is completely uncorrelated with the number of people with the ... But the amount of publicly-funded research on a disease decreases with the share of life-years before age 65 lost to the ... There tends to be more research about chronic conditions that are prevalent among people living in low-income households, and ...
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Responsible research with monkeys and other non-human primates has led to historic medical breakthroughs saving millions of ... Primates in Research. Primate research is essential now and for the future of human health. ... Sign up to receive a complimentary copy of the white paper, The Critical Role of Nonhuman Primates in Medical Research.. ... 95 percent of animal research is conducted with rats and mice. But they can only tell us so much. Once a disease or drug is ...
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On the ninth anniversary of his passing, the Foundation for Biomedical Research (FBR) remembers the extraordinary life and ... Animal Research: The Quest to End Childhood Cancers Sep 28, 2017 Statistics offer a powerful, if incomplete, picture of the ... Research shows family history plays a role in Alzheimer's disease. It's an emotionally devastating scene in "Still Alice," the ... The most promising research in Alzheimer's disease is conducted with animal models.. Jun 8, 2017 ...
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Bailey has been named President of the Foundation for Biomedical Research (FBR) and the National Association for Biomedical ... our class learned about animal research in biomedical studies. After Ms. Gurney's presentation on her research experience using ... How Animal Research Helps Livestock. Sep 1, 2016 This is the final installment of our four-part series on how animal research ... Significant Advancement Biomedical research is breaking ground in finding ways to help the more than 250,000 Americans ...
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Biomedical Research Volume 21 Issue 4 365. Biomedical Research 2010; 21 (4): 365-368 ...
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Biomedical Research 2007; 18 (3): 185-187. Papa Dasari. Department of Obstetrics and Gynaecology, Jawaharlal Institute of ... Postgraduate Medical Education and Research, Pondicherry605 006, India. Key words: Missed abortion, Extra-amniotic prostadin, ...
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Biomedical Research 2006; 17 (1): 49-54. ٭M.C Izegbu, ٭٭O. O. Amole, +G.O.Ajayi. Departments of ٭Morbid Anatomy, ٭٭Pharmacology ...
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Biomedical Research 2007; 18 (2): 106-108. Jyothi d'souza1, Beena V Shetty2, Sudha Ksup,2, Gayathri M Raosup,2. 1Department of ...
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Biomedical Research 2006; 17 (3): 205-210. I. V. Ingole, S. K. Ghosh. Department of Anatomy, Mahatma Gandhi Institute of ... Scientific researches have highlighted some extremely hazardous effects of exposure to radiation emitted by the cell phones on ...
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Systematic Protein Investigative Research EnvironmentAndrew Dickson WhiteInternational Workshop on Nitride Semiconductors: The International Workshop on Nitride Semiconductors (IWN) is a biennial academic conference in the field of group III nitride research. The IWN and the International Conference on Nitride Semiconductors (ICNS) are held in alternating years and cover similar subject areas.Toronto Western Research Institute: The Toronto Western Research Institute (TWRI) is a non-profit academic medical research institute located in Canada’s largest city, Toronto. The TWRI is one the principal research institutes of the University Health Network of academic teaching hospitals associated with the University of Toronto; the TWRI is also one of the largest research institutes in Canada focussing on human neurological disease from both a basic science and clinical research perspective.Circulation plan: A circulation plan is a schematic empirical projection/model of how pedestrians and/or vehicles flow through a given area, like, for example, a neighborhood or a Central Business District (CBD). Circulation plans are used by city planners and other officials to manage and monitor traffic and pedestrian patterns in such a way that they might discover how to make future improvements to the system.Institute of Biomaterials and Biomedical Engineering: The Institute of Biomaterials and Biomedical Engineering (IBBME) was founded in 1962 at the University of Toronto (U of T). IBBME is home to the common research and teaching interests of the faculties of Applied Science and Engineering, Dentistry, and Medicine at the U of T.Conference and Labs of the Evaluation Forum: The Conference and Labs of the Evaluation Forum (formerly Cross-Language Evaluation Forum), or CLEF, is an organization promoting research in multilingual information access (currently focusing on European languages). Its specific functions are to maintain an underlying framework for testing information retrieval systems and to create repositories of data for researchers to use in developing comparable standards.Science Translational Medicine: Science Translational Medicine is an interdisciplinary medical journal established in October 2009 by the American Association for the Advancement of Science.British Journal of Diabetes and Vascular Disease: The British Journal of Diabetes and Vascular Disease is a peer-reviewed academic journal that publishes papers six times a year in the field of Cardiovascular medicine. The journal's editors are Clifford J Bailey (Aston University), Ian Campbell (Victoria Hospital) and Christoph Schindler (Dresden University of Technology).Dragomir R. Radev: Dragomir R. Radev is a University of Michigan computer science professor and Columbia University computer science adjunct professor working on natural language processing and information retrieval.UK Biobank: UK Biobank is a large long-term biobank study in the United Kingdom (UK) which is investigating the respective contributions of genetic predisposition and environmental exposure (including nutrition, lifestyle, medications etc.) to the development of disease.Human subject research legislation in the United States: Human subject research legislation in the United States can be traced to the early 20th century. Human subject research in the United States was mostly unregulated until the 20th century, as it was throughout the world, until the establishment of various governmental and professional regulations and codes of ethics.Israel and animal welfare: Israel's protection of animal welfare rests upon the Animal Welfare Law, 1994 which is composed of an Animal Protection Law and an Animal Experimentation Law. The law was originally introduced by Abraham Poraz in 1993 and passed by the Knesset on January 11, 1994.Research participant: A research participant, also called a human subject or an experiment, trial, or study participant or subject, is a person who participates in human subject research by being the target of observation by researchers.Process mining: Process mining is a process management technique that allows for the analysis of business processes based on event logs. The basic idea is to extract knowledge from event logs recorded by an information system.SciDBJournal of Aging and Health: The Journal of Aging and Health (JAH) is a medical journal covering aging published by SAGE Publications. It covers research on gerontology, including diet/nutrition, prevention, behaviors, health service utilization, longevity, and mortality.Semantic translation: Semantic translation is the process of using semantic information to aid in the translation of data in one representation or data model to another representation or data model. Semantic translation takes advantage of semantics that associate meaning with individual data elements in one dictionary to create an equivalent meaning in a second system.List of youth publications: __NOTOC__International Committee on Aeronautical Fatigue and Structural IntegrityMassachusetts Animal Rights Coalition: The Massachusetts Animal Rights Coalition (MARC), is a non-profit volunteer-run animal rights organization based in Massachusetts, United States. MARC is the largest and most active animal rights group in Massachusetts and operates as a tax exempt 501(c)(3) corporationhttp://corp.List of Parliamentary constituencies in Kent: The ceremonial county of Kent,Desiderata of the Lombards: Desiderata or Ermengarda was one of four daughters of Desiderius, king of the Lombards, and his queen, Ansa. She was married to Charlemagne, king of the Franks, in 770, probably to form a bond between the otherwise enemy states of Francia and Lombardy.Eden Prairie Library: The Eden Prairie Library is located in Eden Prairie, Minnesota and is one of 41 libraries of the Hennepin County Library system. The 40,000 square foot building houses a collection of 150,000 items, an automated materials handling system (AMH) for check in and rough sortation of materials, 82 public computers, two meeting rooms, a reading lounge with fireplace, a teen area, a children's area with a Family Reading Lounge, and several installations of artwork.MBF BiosciencePSI Protein Classifier: PSI Protein Classifier is a program generalizing the results of both successive and independent iterations of the PSI-BLAST program. PSI Protein Classifier determines belonging of the found by PSI-BLAST proteins to the known families.Nihon UniversityUniversity of Toronto Joint Centre for Bioethics: The University of Toronto Joint Centre for Bioethics, or JCB, is an academic research centre located on the downtown campus of the University of Toronto in Toronto, Ontario, Canada. The Joint Centre for Bioethics is a partnership between the University and 15 affiliated health care organizations in the Greater Toronto Area.Translational bioinformatics: Translational Bioinformatics (TBI) is an emerging field in the study of health informatics, focused on the convergence of molecular bioinformatics, biostatistics, statistical genetics, and clinical informatics. Its focus is on applying informatics methodology to the increasing amount of biomedical and genomic data to formulate knowledge and medical tools, which can be utilized by scientists, clinicians, and patients.Internet organizations: This is a list of Internet organizations, or organizations that play or played a key role in the evolution of the Internet by developing recommendations, standards, and technology; deploying infrastructure and services; and addressing other major issues.The Flash ChroniclesReturn of results: Return of results is a concept in research ethics which describes the extent of the duty of a researcher to reveal and explain the results of research to a research participant.Concurrency semantics: In computer science, concurrency semantics is a way to give meaning to concurrent systems in a mathematically rigorous way. Concurrency semantics is often based on mathematical theories of concurrency such as various process calculi, the actor model, or Petri nets.Mac OS X Server 1.0Polarized light pollution: Polarization is a property of light waves that describes the orientation of their oscillations. Polarized light pollutionGábor Horváth, György Kriska, Péter Malik, Bruce Robertson.The Detroit Project: The Detroit Project was a group that lobbies American automakers to build cars and SUVs that have higher fuel efficiency and use alternative fuels. The group also lobbied politicians to take action to reducing United States petroleum dependence.Scientific misconduct: Scientific misconduct is the violation of the standard codes of scholarly conduct and ethical behavior in professional scientific research. A Lancet review on Handling of Scientific Misconduct in Scandinavian countries provides the following sample definitions: (reproduced in The COPE report 1999.Biomedical waste: Biomedical waste is waste that is either putrescible or potentially infectious.Reinhardt, Peter A.Clonal Selection Algorithm: In artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic hypermutation.David S. Cafiso: David S. Cafiso (born 18 March 1952) is an American biochemist and a Professor of Chemistry at the University of Virginia.John Scott Haldane: John Scott Haldane CH FRS (; 2 May 1860 – 14/15 March 1936) was a Scottish physiologist famous for intrepid self-experimentation which led to many important discoveries about the human body and the nature of gases. He also experimented on his son, the equally famous J.Indian Veterinary Research InstituteBoss CoffeeTheory of Motivated Information Management: Theory of Motivated Information Management or TMIM, is a social-psychological framework that examines the relationship between information management and uncertainty. The theory posits that individuals are “motivated to manage their uncertainty levels when they perceive a discrepancy between the level of uncertainty they have about an important issue and the level of uncertainty they want” (Guerrero et al.Document-centric collaboration: Document-centric collaboration is a new approach to working together on projects online which puts the document and its contents at the centre of the process.Salt (cryptography): In cryptography, a salt is random data that is used as an additional input to a one-way function that hashes a password or passphrase.Salts are closely related to the concept of nonce.Immersive technologyOntario Genomics Institute: The Ontario Genomics Institute (OGI) is a not-for-profit organization that manages cutting-edge genomics research projects and platforms.The Ontario Genomics Institute OGI also helps scientists find paths to the marketplace for their discoveries and the products to which they lead, and it works through diverse outreach and educational activities to raise awareness and facilitate informed public dialogue about genomics and its social impacts.The International Journal of Advanced Manufacturing Technology: The International Journal of Advanced Manufacturing Technology is a peer-reviewed scientific journal published by Springer. The journal publishes 36 issues per year.Mexican International Conference on Artificial Intelligence: MICAI (short for Mexican International Conference on Artificial Intelligence) is the name of an annual conference covering all areas of Artificial Intelligence (AI), held in Mexico. The first MICAI conference was held in 2000.Nencki Institute of Experimental Biology: The Nencki Institute of Experimental Biology is a Polish scientific research organization and a part of Polish Academy of Sciences headquartered in Warsaw, Poland. Founded in 1918, it is a leading institution in the country in the field of neurobiology, molecular biology and biochemistry.Footprints (poem): "Footprints", also known as "Footprints in the Sand", is a popular allegorical text written in prose.Antenor Orrego Private UniversityCertified Tissue Bank Specialist: A Certified Tissue Bank Specialist (CTBS) designation is a professional certification mark for Tissue Banking Professionals conferred by the American Association of Tissue Banks (AATB). AATB oversees musculoskeletal, cardiovascular, skin and reproductive tissue banks in the United States.The Republican War on Science: The Republican War on Science is a 2005 book by Chris C. Mooney, an American journalist who focuses on the politics of science policy.Zugunruhe: Zugunruhe (pronounced ) is a German compound word consisting of Zug (move, migration) and Unruhe (anxiety, restlessness).Statutory auditor: Statutory auditor is a title used in various countries to refer to a person or entity with an auditing role, whose appointment is mandated by the terms of a statute.Federal Employees Health Benefits Program: The Federal Employees Health Benefits (FEHB) Program is a system of "managed competition" through which employee health benefits are provided to civilian government employees and annuitants of the United States government.Medix UK Limited: Medix UK Limited is a UK-based market research consultancy providing online research in healthcare.Lasker Award: The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, founded by Albert Lasker and his wife Mary Woodard Lasker (later a medical research activist).Companies OfficeExtracellular: In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell". This space is usually taken to be outside the plasma membranes, and occupied by fluid.Erga omnes: Erga omnes is a Latin phrase which means "towards all" or "towards everyone". In legal terminology, erga omnes rights or obligations are owed toward all.Biotechnology Industry Organization: The Biotechnology Industry Organization (BIO) is the largest trade organization to serve and represent the biotechnology industry in the United States and around the world.Anna Edney, "Biosciences Defy U.United States Public Health ServiceThe Gentlemen's Alliance CrossGenetic predisposition: A genetic predisposition is a genetic characteristic which influences the possible phenotypic development of an individual organism within a species or population under the influence of environmental conditions. In medicine, genetic susceptibility to a disease refers to a genetic predisposition to a health problem,What does it mean to have a genetic predisposition to a disease?Patient-Reported Outcomes Measurement Information System: The Patient Reported Outcomes Measurement Information System (PROMIS®) provides clinicians and researchers access to reliable, valid, and flexible measures of health status that assess physical, mental, and social well–being from the patient perspective. PROMIS measures are standardized, allowing for assessment of many patient-reported outcome domains—including pain, fatigue, emotional distress, physical functioning and social role participation—based on common metrics that allow for comparisons across domains, across chronic diseases, and with the general population.

(1/4142) Selecting subjects for participation in clinical research: one sphere of justice.

Recent guidelines from the US National Institutes of Health (NIH) mandate the inclusion of adequate numbers of women in clinical trials. Ought such standards to apply internationally? Walzer's theory of justice is brought to bear on the problem, the first use of the theory in research ethics, and it argues for broad application of the principle of adequate representation. A number of practical conclusions for research ethics committees (RECs) are outlined. Eligibility criteria in clinical trials ought to be justified by trial designers. Research ethics committees ought to question criteria that seem to exclude unnecessarily women from research participation. The issue of adequate representation should be construed broadly, so as to include consideration of the representation of the elderly, persons with HIV, mental illness and substance abuse disorders in clinical research.  (+info)

(2/4142) Views of managed care--a survey of students, residents, faculty, and deans at medical schools in the United States.

BACKGROUND AND METHODS: Views of managed care among academic physicians and medical students in the United States are not well known. In 1997, we conducted a telephone survey of a national sample of medical students (506 respondents), residents (494), faculty members (728), department chairs (186), directors of residency training in internal medicine and pediatrics (143), and deans (105) at U.S. medical schools to determine their experiences in and perspectives on managed care. The overall rate of response was 80.1 percent. RESULTS: Respondents rated their attitudes toward managed care on a 0-to-10 scale, with 0 defined as "as negative as possible" and 10 as "as positive as possible." The expressed attitudes toward managed care were negative, ranging from a low mean (+/-SD) score of 3.9+/-1.7 for residents to a high of 5.0+/-1.3 for deans. When asked about specific aspects of care, fee-for-service medicine was rated better than managed care in terms of access (by 80.2 percent of respondents), minimizing ethical conflicts (74.8 percent), and the quality of the doctor-patient relationship (70.6 percent). With respect to the continuity of care, 52.0 percent of respondents preferred fee-for-service medicine, and 29.3 percent preferred managed care. For care at the end of life, 49.1 percent preferred fee-for-service medicine, and 20.5 percent preferred managed care. With respect to care for patients with chronic illness, 41.8 percent preferred fee-for-service care, and 30.8 percent preferred managed care. Faculty members, residency-training directors, and department chairs responded that managed care had reduced the time they had available for research (63.1 percent agreed) and teaching (58.9 percent) and had reduced their income (55.8 percent). Overall, 46.6 percent of faculty members, 26.7 percent of residency-training directors, and 42.7 percent of department chairs reported that the message they delivered to students about managed care was negative. CONCLUSIONS: Negative views of managed care are widespread among medical students, residents, faculty members, and medical school deans.  (+info)

(3/4142) The relation between funding by the National Institutes of Health and the burden of disease.

BACKGROUND: The Institute of Medicine has proposed that the amount of disease-specific research funding provided by the National Institutes of Health (NIH) be systematically and consistently compared with the burden of disease for society. METHODS: We performed a cross-sectional study comparing estimates of disease-specific funding in 1996 with data on six measures of the burden of disease. The measures were total mortality, years of life lost, and number of hospital days in 1994 and incidence, prevalence, and disability-adjusted life-years (one disability-adjusted life-year is defined as the loss of one year of healthy life to disease) in 1990. With the use of these measures as explanatory variables in a regression analysis, predicted funding was calculated and compared with actual funding. RESULTS: There was no relation between the amount of NIH funding and the incidence, prevalence, or number of hospital days attributed to each condition or disease (P=0.82, P=0.23, and P=0.21, respectively). The numbers of deaths (r=0.40, P=0.03) and years of life lost (r=0.42, P=0.02) were weakly associated with funding, whereas the number of disability-adjusted life-years was strongly predictive of funding (r=0.62, P<0.001). When the latter three measures were used to predict expected funding, the conclusions about the appropriateness of funding for some diseases varied according to the measure used. However, the acquired immunodeficiency syndrome, breast cancer, diabetes mellitus, and dementia all received relatively generous funding, regardless of which measure was used as the basis for calculating support. Research on chronic obstructive pulmonary disease, perinatal conditions, and peptic ulcer was relatively underfunded. CONCLUSIONS: The amount of NIH funding for research on a disease is associated with the burden of the disease; however, different measures of the burden of disease may yield different conclusions about the appropriateness of disease-specific funding levels.  (+info)

(4/4142) Research, ethics and conflicts of interest.

In this paper, I have tried to develop a critique of committee procedures and conflict of interest within research advisory committees and ethical review committees (ERCs). There are specific features of conflict of interest in medical research. Scientists, communities and the subjects of research all have legitimate stakeholdings. The interests of medical scientists are particularly complex, since they are justified by the moral and physical welfare of their research subjects, while the reputations and incomes of scientists depend on the success of their science. Tensions of this kind must at times produce conflict of interest. It is important to recognise that conflicts of interest may unwittingly lead to manipulation of research subjects and their lay representatives on research committees. It is equally important to recognise distinctions between the legal and moral aspects of conflict of interest. Some practical suggestions are made which may go some way towards resolving these difficulties. They indicate what might be needed to ensure the validity of ethical discourse, and to reduce the risks associated with conflict of interest.  (+info)

(5/4142) Fraud, misconduct or normal science in medical research--an empirical study of demarcation.

OBJECTIVES: To study and describe how a group of senior researchers and a group of postgraduate students perceived the so-called "grey zone" between normal scientific practice and obvious misconduct. DESIGN: A questionnaire concerning various practices including dishonesty and obvious misconduct. The answers were obtained by means of a visual analogue scale (VAS). The central (two quarters) of the VAS were designated as a grey zone. SETTING: A Swedish medical faculty. SURVEY SAMPLE: 30 senior researchers and 30 postgraduate students. RESULTS: Twenty of the senior researchers and 25 of the postgraduate students answered the questionnaire. In five cases out of 14 the senior researchers' median was found to be clearly within the interval of the grey zone, compared with three cases for the postgraduate students. Three examples of experienced misconduct were provided. Compared with postgraduate students, established researchers do not call for more research ethical guidelines and restrictions. CONCLUSION: Although the results indicate that consensus exists regarding certain obvious types of misconduct the response pattern also indicates that there is no general consensus on several procedures.  (+info)

(6/4142) Coverage by the news media of the benefits and risks of medications.

BACKGROUND: The news media are an important source of information about new medical treatments, but there is concern that some coverage may be inaccurate and overly enthusiastic. METHODS: We studied coverage by U.S. news media of the benefits and risks of three medications that are used to prevent major diseases. The medications were pravastatin, a cholesterol-lowering drug for the prevention of cardiovascular disease; alendronate, a bisphosphonate for the treatment and prevention of osteoporosis; and aspirin, which is used for the prevention of cardiovascular disease. We analyzed a systematic probability sample of 180 newspaper articles (60 for each drug) and 27 television reports that appeared between 1994 and 1998. RESULTS: Of the 207 stories, 83 (40 percent) did not report benefits quantitatively. Of the 124 that did, 103 (83 percent) reported relative benefits only, 3 (2 percent) absolute benefits only, and 18 (15 percent) both absolute and relative benefits. Of the 207 stories, 98 (47 percent) mentioned potential harm to patients, and only 63 (30 percent) mentioned costs. Of the 170 stories citing an expert or a scientific study, 85 (50 percent) cited at least one expert or study with a financial tie to a manufacturer of the drug that had been disclosed in the scientific literature. These ties were disclosed in only 33 (39 percent) of the 85 stories. CONCLUSIONS: News-media stories about medications may include inadequate or incomplete information about the benefits, risks, and costs of the drugs as well as the financial ties between study groups or experts and pharmaceutical manufacturers.  (+info)

(7/4142) A national survey of policies on disclosure of conflicts of interest in biomedical research.

BACKGROUND: Conflicts of interest pose a threat to the integrity of scientific research. The current regulations of the U.S. Public Health Service and the National Science Foundation require that medical schools and other research institutions report the existence of conflicts of interest to the funding agency but allow the institutions to manage conflicts internally. The regulations do not specify how to do so. METHODS: We surveyed all medical schools (127) and other research institutions (170) that received more than $5 million in total grants annually from the National Institutes of Health or the National Science Foundation; 48 journals in basic science and clinical medicine; and 17 federal agencies in order to analyze their policies on conflicts of interest. RESULTS: Of the 297 institutions, 250 (84 percent) responded by March 2000, as did 47 of the 48 journals and 16 of the 17 federal agencies. Fifteen of the 250 institutions (6 percent)--5 medical schools and 10 other research institutions--reported that they had no policy on conflicts of interest. Among the institutions that had policies, there was marked variation in the definition and management of conflicts. Ninety-one percent had policies that adhered to the federal threshold for disclosure ($10,000 in annual income or equity in a relevant company or 5 percent ownership), and 9 percent had policies that exceeded the federal guidelines. Only 8 percent had policies requiring disclosure to funding agencies, only 7 percent had such policies regarding journals, and only 1 percent had policies requiring the disclosure of information to the relevant institutional review boards or to research subjects. Twenty journals (43 percent) reported that they had policies requiring disclosure of conflicts of interest. Only four federal agencies had policies that explicitly addressed conflicts of interest in extramural research, and all but one of the agencies relied primarily on institutional discretion. CONCLUSIONS: There is substantial variation among policies on conflicts of interest at medical schools and other research institutions. This variation, combined with the fact that many scientific journals and funding agencies do not require disclosure of conflicts of interest, suggests that the current standards may not be adequate to maintain a high level of scientific integrity.  (+info)

(8/4142) Publication ethics and the research assessment exercise: reflections on the troubled question of authorship.

The research assessment exercise (RAE) forms the basis for determining the funding of higher education institutions in the UK. Monies are distributed according to a range of performance criteria, the most important of which is "research outputs". Problems to do with publication misconduct, and in particular, issues of justice in attributing authorship, are endemic within the research community. It is here argued that the research assessment exercise currently makes no explicit attempt to address these concerns, and indeed, by focusing attention on research outputs, may actually be fostering such ethical problems.  (+info)

  • 2016
  • In 2016, K-RITH merged with the Africa Centre to form the Africa Health Research Institute (AHRI). (
  • In August 2016, to counter criticism from animal rights' groups, a white paper coauthored by nine of the most premier scientific groups and titled The Critical Role of Nonhuman Primates in Medical Research was released. (
  • In 2016, the BRC was awarded its third tranche: another £111 million in research funds from the NIHR, for the cycle beginning in April 2017. (
  • Government efforts to increase allocations to research between 2013 and 2016 were often thwarted by the congressional austerity drive, with Congress withholding approval of the federal government's budget several times. (
  • NABR
  • NABR reports to provide the unified voice for the scientific community on legislative and regulatory matters affecting laboratory animal research over its 30-year history. (
  • NABR has worked to ensure that biomedical research using animals remains possible, acting on behalf of approximately 300 public and private universities, medical and veterinary schools, teaching hospitals, voluntary health agencies, professional societies, pharmaceutical and biotech companies, and other animal research-related interests. (
  • During debate on the 1985 reauthorization of the Farm bill, NABR successfully obtained modifications to the Animal Welfare Act amendments that aimed to provide a consistent and reasonable framework in which research facilities can operate. (
  • NABR also helped defeat several policies, including the Information Dissemination and Research Accountability Act", that it considered would have put obstacles in the way of research. (
  • 2000
  • Chinese: 生物医药研究理事会) is a research council in Singapore, established in October 2000. (
  • In 2000 BMC established long term collaboration with Switzerland company „Cytos Biotechnology" Ltd. concerning research of virus structural gene exploration in order to construct virus like particles that could serve as vaccines or immunomodulating therapeutics. (
  • Of almost 2000 biomedical articles published by UAE-based researchers between 1998 and 2007, only 5 (0.3%) have appeared in major international medical journals. (
  • Pharmacology
  • Human genetics Recombinant biotechnology Molecular virology Cancer research Epidemiology of infectious diseases Molecular pharmacology Stem cells Structural biology The research and infrastructure is supported by funding from the Latvian Council of Science, Ministry of Education and Science, various European funding programmes like the European Social Fund, European Regional Development Fund, as well as by industry. (
  • clusters
  • About 1,400 people are employed in the PRBB, making it one of the largest biomedical research clusters in the south of Europe. (
  • Countries known for their science and technology capabilities tend to lead the world in the percentage of GDP allocated for R&D. Biomedical R&D has a positive impact on economic growth through the creation of jobs through clusters of businesses that are related to each other. (
  • vitro fertilization
  • It was best known for the development of the combined oral contraceptive pill by Pincus and Min Chueh Chang, an important development in modern birth control, and for pioneering research on in vitro fertilization by Chang. (
  • discoveries
  • The HHMI Investigator Program supports nearly 300 investigators, located at more than 60 research institutions across the United States, who are widely known for their scientific discoveries, their innovation, and their success in pushing the bounds of knowledge in biomedical research. (
  • Primates
  • Learn more about the essential role of primates in research. (
  • In fact, recent research shows that 98% of the current drug pipeline relies on either dogs or non-human primates. (
  • Because of their incredible similarity to humans, primates such as rhesus macaques and chimpanzees, up until the National Institutes of Health ended public funding for chimpanzee research, have greatly contributed to many areas of medicine. (
  • scientific research
  • Members of the club continue to meet and support scientific research at Texas Biomed today with their time and resources. (
  • Qatar has committed 2.8% of GDP towards R&D [full citation needed] and Saudi Arabia has allocated US$32 billion towards higher education, training, science and technology and academic R&D. Organizations such as the Qatar Foundation, the National Authority for Scientific Research (UAE) and the Arab Science and Technology Foundation co-ordinate and support R&D efforts at national and regional levels. (
  • aims
  • Our Biomedical Research Group (BRG) aims to integrate research into the genotypic and phenotypic relationships underpinning our understanding of health, disease and ageing in human, animal and microbial systems. (
  • The PRBB is the product of an initiative launched by the Government of Catalonia, the City Council of Barcelona and the Pompeu Fabra University (UPF), which aims to promote research and collaboration between closely related fields. (
  • development
  • The Council works in close partnership with the Economic Development Board's (EDB) Biomedical Sciences Group and Bio*One Capital. (
  • Canine research has led to many significant breakthroughs such as hip replacements, development of cancer treatments, and research in stem cells, diabetes, and Alzheimer's disease. (
  • Significant development of infrastructure took place after financial support from State Research Program. (
  • The USA carries out 46% of global research and development (R&D) in life sciences, making it the world leader. (
  • public
  • Developed invaluable animal models for research on cancer, heart disease, obesity, AIDS, and hepatitis among other public health problems that afflict millions around the globe. (
  • Founded by physicians seeking solutions to the diversity of public health problems they experienced every day in one of the nation's busiest hospitals, LA BioMed supports research to find real-world solutions to real-world health problems around the world. (
  • Over 40, mostly public sector, institutions are involved in biomedical R&D and most offer research grants. (
  • In April 2013, the government announced another public−private partnership, this time to implement its Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. (
  • novel vaccine
  • More recently, it's become an incubator of biomedical startups, including companies that are developing a novel vaccine to prevent the superbug MRSA and fungal infections, a device to detect when babies are in danger of succumbing to sudden infant death syndrome and therapies to prevent painful sickle cell crises. (
  • Genetics
  • In 2001 novel collaboration project financed by Latvian Council of Science "Genofond research of population of Latvia and its application for human pathology diagnostics and profilaxis" begun that promoted research of human genetics in Latvia. (
  • grants
  • The number of research grants mentioning a chronic condition is completely uncorrelated with the number of people with the condition but very strongly positively related to the number of people whose activities are limited by that condition. (
  • medical
  • After years of research, a medical milestone has now been. (
  • In case you missed it: Part 1 of this series explored the importance of Lyme disease research for human and veterinary medical science. (
  • Medical advances of the past century, ranging from vaccines to organ transplants to cancer treatment, were made possible by animal research. (
  • According to the Foundation for Biomedical Research, animal research has been responsible for every medical breakthrough over the past century, although this position has been disputed by some animal rights activists and organizations. (
  • In 1981 ABR President Dr. Edward C. Melby testified before Congress on the important role of animals in medical research. (
  • One of Los Angeles' largest and most advanced medical research institutes, LA BioMed got its start in a collection of army barracks that had originally been part of the Los Angeles Port of Embarkation Hospital during World War II. (
  • community
  • The Hanna H. Gray Fellows Program supports diversity in the biomedical research community by recruiting and retaining individuals from groups underrepresented in the life sciences. (
  • The animal research [community] has a history of silence that we are beginning to understand must be broken. (
  • laboratory animal
  • This is the second of a two-part blog post that shares the journey of someone who, from heartache, found her purpose and passion for laboratory animal care and research. (
  • organizations
  • In 1986, as an advocate of a strong national enforcement program of animal research facilities, the association joined with 100 scientific and animal welfare organizations to urge adequate funding for the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS). (
  • INBRE are intended to enhance the caliber of scientific faculty at research institutions and undergraduate schools, thereby attracting more promising students to these organizations and to improving the biomedical workforce of the state in which the INBRE is located. (
  • Disease
  • But the amount of publicly-funded research on a disease decreases with the share of life-years before age 65 lost to the disease that are lost by non-whites, perhaps because lack of scientific knowledge is a less important cause of premature mortality among non-whites than it is among whites. (
  • The most promising research in Alzheimer's disease is conducted with animal models. (
  • Research shows family history plays a role in Alzheimer's disease. (
  • In 1977 I started reading all the previous year's research on this disease. (
  • In November 2012 it was announced that BRC-supported research had resulted in the discovery of a genetic mutation that increases the risk of developing Alzheimer's disease. (
  • Study
  • The legislation would have mandated that 30-50 percent of federal dollars currently spent on animal research be diverted to study alternatives. (
  • Exposure
  • Scientific researches have highlighted some extremely hazardous effects of exposure to radiation emitted by the cell phones on the human body like disruption of learned behavior, headache, fatigue, dysaesthesia etc [1,2, (
  • animal
  • 95 percent of animal research is conducted with rats and mice. (
  • Easy-to-read articles about animal testing and research. (
  • Another year, another Nobel Prize awarded with the help of animal research. (
  • In the U.S., the numbers of rats and mice used in animal research is estimated at 20 million a year, or 95% of the total number of lab animals. (
  • The Foundation advocates the highest quality of animal care and treatment, stating that the use of animals in research is a privilege, and that animals deserve our respect and the best possible care. (
  • In 1979, the "Research Animal Alliance", a group of companies and individuals seeking to protect animal research, formed in Boston, MA and successfully guided legislation that would affect the future of biomedical research relying on animal models. (
  • During reauthorization of the 2002 Farm bill, the association was successful in obtaining a statutory exemption under the Animal Welfare Act of coverage of rats, mice and birds used for research. (
  • activities
  • The BRC's research activities are organised into four broad programmes: Cancer Cardiometabolism Infection, immunity and inflammation Neuroscience In 2011, Department of Health (DH) analysis showed that the UCL and UCLH partnership generated 11% of all highly cited biomedical research papers produced in the United Kingdom. (