Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Asperger Syndrome: A disorder beginning in childhood whose essential features are persistent impairment in reciprocal social communication and social interaction, and restricted, repetitive patterns of behavior, interests, or activities. These symptoms may limit or impair everyday functioning. (From DSM-5)Child Development Disorders, Pervasive: Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.Irritable Mood: Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.Social Behavior Disorders: Behaviors which are at variance with the expected social norm and which affect other individuals.Chromosomes, Human, Pair 15: A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.Genetic Markers: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.Linkage Disequilibrium: Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.Anxiety Disorders: Persistent and disabling ANXIETY.Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.

*  Article: Athletes with ADHD & Autistic Spectrum Disorder (ASD) | Futurehealth
Autistic Spectrum Disorder (ASD) - # An estimated 8-10% (possibly up to 20%) professional athletes have ADHD (compared to four ... Athletes with ADHD & Autistic Spectrum Disorder (ASD). By Michael Linden (Page 1 of 1 pages) Permalink ... Advances in the Diagnosis & Treatment of ADD and Autistic Spectrum Disorder ADD Workshop ADD at Work, at Home Polycontrast ... Related Topic(s): Adhd; Anxiety; Aspergers; Athletic; Attention; Autistic Spectrum Disorder; Baseball; Brain; Neurofeedback; ...
  https://www.futurehealth.org/articles/Athletes-with-ADHD--Auti-by-Michael-Linden-100424-956.html
*  What is Autistic Spectrum Disorder (ASD)?
... tailored care for adults with Autistic Spectrum Disorder & Aspergers Syndrome ... What is Autistic Spectrum Disorder (ASD)?. Autism is an increasingly well known disorder, first identified in 1943. People are ... However, few realise just how complex Autism, Aspergers & autistic spectrum disorders can be. ...
  http://www.moduscare.com/faq/autistic-spectrum-disorder-asd.html
*  Education of Pupils with Autistic Spectrum Disorder at Dublin City University | gradireland
Understanding Autism: aims to provide a foundation in the history, concept and diagnosis of autistic spectrum disorder, causes ... a post currently funded by the Department of Education and Skills and who are currently working with students on the Autistic ... a post currently funded by the Department of Education and Skills and who are currently working with students on the Autistic ...
  https://gradireland.com/institution/dublin-city-university/546007-education-of-pupils-with-autistic-spectrum-disorder
*  Gastrointestinal Factors in Autistic Disorder: A Critical Review | SpringerLink
... factors of autistic disorder (autism) has developed from descriptions of symptoms such as constipation and diarrhea in autistic ... factors of autistic disorder (autism) has developed from descriptions of symptoms such as constipation and diarrhea in autistic ... High prevalence of gastrointestinal symptoms in autistic children with autistic spectrum disorder Journal of Pediatric ... Patel N. C., Yeh J. Y., Shepherd M. D., Crismon M. L. (2002). Secretin treatment for autistic disorder: A critical analysis ...
  https://link.springer.com/article/10.1007%2Fs10803-005-0019-4
*  Marketplace: Autistic Spectrum Disorder
Track your students' progress using real-time statistics.: What is it like to have Autistic Spectrum Disorder? What are the ... identified in enough people in the same kinds of ways to be labeled as a specific disorder such as Autistic Spectrum Disorder ( ... ASD), Attention Deficit/Hyperactivity Disorder (ADHD) and Dyslexia. ... Autistic Spectrum Disorder. What is it like to have Autistic Spectrum Disorder? What are the challenges someone with ASD faces ...
  http://lessonplans.symbaloo.com/marketplace/detail/3556
*  Questioning Answers: NICE guidelines on autism diagnosis published
The National Autistic Society (NAS) carry the news (here) but the full guidance on pathways to diagnosis in the UK can be ... Adolescents with ASD [autism spectrum disorder] spent less time in MVPA [ moderate and vigorous physical activity ] compared to ... ADHD [ attention-deficit hyperactivity disorder ] patients were overrepresented in the group with low levels of some vitamins, ...
  https://questioning-answers.blogspot.co.uk/2011/09/nice-guidelines-on-autism-diagnosis.html
*  Autistic Spectrum Disorders Support Service - Trinity Disability Service - Trinity College Dublin
Autistic Spectrum Disorders Support Service Trinity College Dublin, like other third level institutions has seen a rise in the ... This webpage provides information and advice for students with Autistic Spectrum Disorders who are thinking about coming to ... links for student guides on helping you manage your role as a student with Asperger's Syndrome or Autistic Spectrum Disorder at ... one of the greatest increases in student numbers attending university are those individuals with Autistic Spectrum Disorders ( ...
  http://www.tcd.ie/disability/services/ASD-Support.php
*  What is AUTISTIC SPECTRUM DISORDER in one paragraph! - Jelbean 5x
Q.What are Autism Spectrum Disorders?. A. Autism Spectrum Conditions, for short ASC's (we don't like 'disorders') are a ... Here at Jelibean we do not believe that ASC's are a deficit, disability or disorder, we prefer 'difference'. Many professionals ...
  http://jelibean.com/index.php?option=com_content&view=article&id=168:what-is-autistic-spectrum-disorder-in-one-paragraph&catid=11&Itemid=39
*  A Prospective Study Comparing the Mifne Approach of Treating Childhood Autism With Routine Standard Treatment - Full Text View ...
Autism Spectrum Disorder. Autistic Disorder. Pervasive Developmental Disorder. Additional relevant MeSH terms: ... Child Development Disorders, Pervasive Behavioral: Mifne Approach to PDD Behavioral: Treatment as usual ... All children between the ages of 2-5 years who meet diagnostic criteria for Autism or Pervasive Developmental Disorder by DSM ... The current study aims at comparing outcomes achieved using the Mifne approach of treating autistic children with results ...
  https://clinicaltrials.gov/ct2/show/NCT00445471?recr=Open&cond=%22Developmental+Disabilities%22&rank=16
*  Health, Autistic Spectrum Disorder
In January of 2000 a group of parents proposed that Autistic Spectrum Disorder (ASD) may be the aftermath of exposure to ... Dr Bradstreet found the mercury burden in autistic children to be 8 times higher than in non-autistics. The main source of this ... OCD is obsessive, compulsive disorder and PANDAS is an acronym for "pediatric autoimmune psychiatric disorders associated with ... are elevated in individuals exhibiting autistic tendencies. There is also some evidence indicating that autistic children also ...
  http://www.springboard4health.com/notebook/health_autism2.html
*  Investigation of Neuroserpin as an Autism Candidate Gene - Full Text View - ClinicalTrials.gov
Autistic Disorder. Child Development Disorders, Pervasive. Neurodevelopmental Disorders. Mental Disorders. Neuroserpin. Serine ... will be used to select twenty autistic multiplex (and if necessary singleplex) families with idiopathic autistic patients who ... It is thus proposed to sequence the neuroserpin gene in initially 20, and subsequently up to 100 idiopathic autistic patients ... All mutations that appear to be good functional candidates will be compared in frequency amongst autistic and control ...
  https://clinicaltrials.gov/ct2/show/NCT00917683
*  Autistic disorder definition | Drugs.com
Definition of autistic disorder. Provided by Stedman's medical dictionary and Drugs.com. Includes medical terms and definitions ... a severe form of pervasive developmental disorder.. *a diagnosis from the Diagnostic and Statistical Manual that is established ...
  https://www.drugs.com/dict/autistic-disorder.html
*  NewYork-Presbyterian Queens - Autistic Disorder
Autistic Disorder. What is autistic disorder?. Autistic disorder (also called autism; more recently described as " ... One theory is the possibility that autistic disorder is a behavioral syndrome that includes several distinct conditions. ... Preventive measures to reduce the incidence or severity of autistic disorders are not known at this time. ... Parents describe autistic infants as "unaffectionate." Autistic infants and children are not comforted by physical contact. ...
  http://www.nyhq.org/diw/Content.asp?PageID=DIW002179&language=Chinese
*  Validity of childhood disintegrative disorder apart from autistic disorder with speech loss | SpringerLink
In order to test clinical validity of DSM-IV childhood disintegrative disorder (CDD), 10 CDD children (mean age = 8.2 years, SD ... autistic disorder childhood disintegrative disorder disintegrative psychosis pervasive developmental disorder speech loss ... American Psychiatric Association (2000) Autistic disorder. In: Diagnostic and Statistical Manual of Mental Disorders, 4th edn. ... Validity of childhood disintegrative disorder apart from autistic disorder with speech loss. ...
  https://link.springer.com/article/10.1007%2Fs00787-004-0397-8
*  Autistic disorder | Article about Autistic disorder by The Free Dictionary
Find out information about Autistic disorder. A severe neuropsychiatric disorder of early childhood onset, historically ... regarded as a psychosis of childhood but now classified as a pervasive... Explanation of Autistic disorder ... Related to Autistic disorder: Asperger's syndrome, Autistic spectrum disorder. Autistic disorder. A severe neuropsychiatric ... Autism spectrum disorders--which include autistic disorder, pervasive developmental disorder-not otherwise specified (PDD-NOS) ...
  https://encyclopedia2.thefreedictionary.com/Autistic+disorder
*  A Short Treatment Study of Aripiprazole in Pediatric Patients With Autistic Disorder - Full Text View - ClinicalTrials.gov
Autistic Disorder. Pathologic Processes. Child Development Disorders, Pervasive. Neurodevelopmental Disorders. Mental Disorders ... A Short Treatment Study of Aripiprazole in Pediatric Patients With Autistic Disorder. The safety and scientific validity of ... Autistic Disorder, children and adolescents. Aripiprazole. Double-blind. Randomized. children and adolescents. ... The patient meets current DSM-IV-TR diagnostic criteria for Autistic Disorder (defined in DSM-IV-TR) and also demonstrates ...
  https://clinicaltrials.gov/ct2/show/NCT01617447?recr=Open&cond=%22Autistic+Disorder%22&rank=5
*  Phase IV Long-term Maintenance Study of Aripiprazole in the Treatment of Irritability Associated With Autistic Disorder - Full...
Autistic Disorder. Pathologic Processes. Child Development Disorders, Pervasive. Neurodevelopmental Disorders. Mental Disorders ... Phase IV Long-term Maintenance Study of Aripiprazole in the Treatment of Irritability Associated With Autistic Disorder. The ... Meets current diagnostic criteria of the Diagnostic and Statistical Manual-of Mental Disorders IV-Text Revised for autistic ... Diagnosis of autistic disorder will be confirmed by the Autism Diagnostic Interview-Revised. ...
  https://clinicaltrials.gov/ct2/show/NCT01227668
*  Journal of Public Health and Epidemiology - impact of environmental factors on the prevalence of autistic disorder after 1979
Increased paternal age and DSM revisions were not related to rising autistic disorder prevalence. Key words: Autism disorder, ... Autistic disorder birth year change points were identified as 1980.9, 1988.4 and 1996 for the US, 1987 for UK, 1990.4 for ... Autistic disorder change points years are coincident with introduction of vaccines manufactured using human fetal cell lines, ... Thus, rising autistic disorder prevalence is directly related to vaccines manufactured utilizing human fetal cells. ...
  http://academicjournals.org/journal/JPHE/article-abstract/C98151247042
*  A Non-Drug Study on the Relationship Between Exploratory Biomarkers and Functional Dimensions in Individuals With Autistic...
Autistic Disorder. Asperger Syndrome. Pathologic Processes. Child Development Disorders, Pervasive. Neurodevelopmental ... Additionally for individuals with Autistic Disorder or Asperger's Syndrome:. * History of epilepsy/seizure disorder (except ... High functioning (IQ ,70) male adult individuals with Autistic Disorder or Asperger's Syndrome and age and IQ matched healthy ... Diagnosis of Autistic Disorder or Asperger's Syndrome as defined by DSM-IV ...
  https://clinicaltrials.gov/ct2/show/NCT01669889?cond=%22Asperger+syndrome%22&rank=5
*  Autistic disorder of childhood onset
... Common Name(s). Autistic disorder of childhood onset ... "Autistic disorder of childhood onset" (open studies are recruiting volunteers) and 775 "Autistic disorder of childhood onset" ... The terms "Autistic disorder of childhood onset" returned 0 free, full-text research articles on human participants. ... The terms "Autistic disorder of childhood onset" returned 0 free, full-text review articles on human participants. ...
  http://diseaseinfosearch.org/Autistic+disorder+of+childhood+onset/7772
*  ERIC - The Role of Early Childhood Professionals in the Early Identification of Autistic Disorder, International Journal of...
Early identification and intervention improves the outcome for autistic children. This article investigates the role of ... Autism is a pervasive developmental disorder defined by impaired social skills, impaired language development and stereotyped ... The Role of Early Childhood Professionals in the Early Identification of Autistic Disorder ... Autism is a pervasive developmental disorder defined by impaired social skills, impaired language development and stereotyped ...
  https://eric.ed.gov/?id=EJ787822
*  Facing Autism in New Brunswick: Do Study Results Involving High Functioning Autism Subjects Automatically Apply to Persons...
Labels: autism awareness, autism research, autistic disorder, cognitive impairment, high functioning autism, intellectual ... Do Study Results Involving High Functioning Autism Subjects Automatically Apply to Persons with Autistic Disorder and ... I understand the difficulties of working with a severely autistic child. My son is severely autistic. We have to learn ways to ... this gives people a lot of false impressions about typical autistic disorder. A lot of people would rather look at a LFA as ' ...
  http://autisminnb.blogspot.com/2010/01/do-study-results-involving-high.html
*  Autistic spectrum disorders | Nordoff Robbins
Read more about Music therapy in the assessment and treatment of autistic spectrum, disorder: Clinical application and research ... Music therapy in the assessment and treatment of autistic spectrum, disorder: Clinical application and research evidence.. ... Therapeutic Dialogues in Music: Nurturing Musicality of Communication in Children with Autistic Spectrum Disorder and Rett ... Evidence from assessment that can identify the expectations of music therapy as a treatment for autistic spectrum disorder (ASD ...
  https://www.nordoff-robbins.org.uk/taxonomy/term/16
*  Autistic Dad: Do not adjust your set
Autistic Dad My name is Gordon Darroch. My two sons have both been diagnosed with Autism Spectrum Disorder (ASD). This is a ... Autistic Dad at 16:14 Email ThisBlogThis!Share to TwitterShare to FacebookShare to Pinterest. ... Nowadays it seems no serious TV drama is complete without a character who is either autistic or displays pronounced autistic ... self-contained autistics on screen and the autistic person living in your street. I can't speak for every one of them, but if I ...
  http://autisticdad.blogspot.com/2012/05/do-not-adjust-your-set.html?showComment=1349018210243

Focus on Autism and Other Developmental Disabilities: Focus on Autism and Other Developmental Disabilities is a peer-reviewed academic journal covering the field of special education. The editors-in-chief are Alisa K.Luke Jackson (author): Luke Christopher Jackson (born 18 August 1988) is the author of Freaks, Geeks, and Asperger Syndrome: A User Guide to Adolescence which was published 15th august 2002, a book penned from first-hand experience about his life with Asperger syndrome. He is also the author of "A User Guide to Cf/Gf Diet for Autism,Asperger Syndrome and ADHD" which was published in 2001.Relationship Development Intervention: Relationship Development Intervention (RDI) is a trademarked proprietary treatment program for autism spectrum disorders (ASD), based on the belief that the development of dynamic intelligence is the key to improving the quality of life for individuals with autism. The program's core philosophy is that individuals with autism can participate in authentic emotional relationships if they are exposed to them in a gradual, systematic way.Disequilibrium (medicine): Disequilibrium}}Nested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.Bipolar disorderMental disorderSocial anxiety disorder

(1/2366) Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism.

OBJECTIVE: To investigate the functional integrity of cerebellar and frontal systems in autism using oculomotor paradigms. BACKGROUND: Cerebellar and neocortical systems models of autism have been proposed. Courchesne and colleagues have argued that cognitive deficits such as shifting attention disturbances result from dysfunction of vermal lobules VI and VII. Such a vermal deficit should be associated with dysmetric saccadic eye movements because of the major role these areas play in guiding the motor precision of saccades. In contrast, neocortical models of autism predict intact saccade metrics, but impairments on tasks requiring the higher cognitive control of saccades. METHODS: A total of 26 rigorously diagnosed nonmentally retarded autistic subjects and 26 matched healthy control subjects were assessed with a visually guided saccade task and two volitional saccade tasks, the oculomotor delayed-response task and the antisaccade task. RESULTS: Metrics and dynamics of the visually guided saccades were normal in autistic subjects, documenting the absence of disturbances in cerebellar vermal lobules VI and VII and in automatic shifts of visual attention. Deficits were demonstrated on both volitional saccade tasks, indicating dysfunction in the circuitry of prefrontal cortex and its connections with the parietal cortex, and associated cognitive impairments in spatial working memory and in the ability to voluntarily suppress context-inappropriate responses. CONCLUSIONS: These findings demonstrate intrinsic neocortical, not cerebellar, dysfunction in autism, and parallel deficits in higher order cognitive mechanisms and not in elementary attentional and sensorimotor systems in autism.  (+info)

(2/2366) Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study.

Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruited by a collaborative group including clinicians from Sweden, France, Norway, the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P -values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11-q13 region identified in previous candidate gene studies. Our study revealed six additional regions on chromosomes 4q, 5p, 6q, 10q, 18q and Xp. We found that the most significant multipoint linkage was close to marker D6S283 (maximum lod score = 2.23, P = 0.0013).  (+info)

(3/2366) Clarifying an ambiguous functional analysis with matched and mismatched extinction procedures.

Results of functional analysis were ambiguous in suggesting that self-injurious behavior (SIB) was maintained by escape, sensory reinforcement, or both. To help clarify these results, we compared escape extinction, sensory extinction, and the combined treatments. Sensory extinction proved to be a necessary and sufficient treatment, whereas escape extinction failed to decrease SIB. These analyses helped to clarify the function of SIB and to identify an effective and efficient treatment.  (+info)

(4/2366) Is integer arithmetic fundamental to mental processing?: the mind's secret arithmetic.

Unlike the ability to acquire our native language, we struggle to learn multiplication and division. It may then come as a surprise that the mental machinery for performing lightning-fast integer arithmetic calculations could be within us all even though it cannot be readily accessed, nor do we have any idea of its primary function. We are led to this provocative hypothesis by analysing the extraordinary skills of autistic savants. In our view such individuals have privileged access to lower levels of information not normally available through introspection.  (+info)

(5/2366) Etiology of infantile autism: a review of recent advances in genetic and neurobiological research.

The etiology of autism is complex, and in most cases the underlying pathologic mechanisms are unknown. Autism is a hetereogeneous disorder, diagnosed subjectively on the basis of a large number of criteria. Recent research has investigated genetics, in utero insults and brain function as well as neurochemical and immunological factors. On the basis of family and twin studies, there appears to be a genetic basis for a wide "autistic syndrome." About a quarter of cases of autism are associated with genetic disorders such as fragile X syndrome or with infectious diseases such as congenital rubella. Genetic studies have shown an association between autism markers of brain development such as 3 markers of the c-Harvey-ros oncogene and the homeobox gene EN2. In some cases, autism is associated with insults early in gestation, including thalidomide embryopathy. Autism may arise from abnormal central nervous system functioning, since most autistic patients have indications of brain dysfunction, and about half of them have abnormal electroencephalograms. Similarly, the pattern of evoked response potentials and conduction time is altered in autistic children. There is substantial evidence from neuroimaging studies that dysfunctions in the cerebellum and possibly the temporal lobe and association cortex occur in autistic symptoms. Neurochemical studies have investigated the role of serotonin, epinephrine and norepinephrine, since levels of these neurotransmitters are altered in autism, although other hypotheses implicate overactive brain opioid systems and changes in oxytocin neurotransmission. Autoimmunity may also play a role; antibodies against myelin basic protein are often found in children with autism, who also have increased eosinophil and basophil response to IgE-mediated reactions. In summary, the prevailing view is that autism is caused by a pathophysiologic process arising from the interaction of an early environmental insult and a genetic predisposition.  (+info)

(6/2366) Heterogeneity and the genetics of autism.

The objective of this review is to summarize recent data on the genetics of autism, highlight the evidence for genetic heterogeneity and extend the implications of these findings for the identification of susceptibility genes in this disorder. Family studies have shown that autism runs in families and twin studies indicate that the basis of that familial aggregation is genetic. As a result the prospects for the identification of susceptibility genes using either linkage or association studies are quite good. However, recent evidence is accumulating suggesting that the disorder is genetically heterogeneous; higher functioning individuals with autism may arise from separate genetic mechanisms that lower functioning ones. If true, this will make the detection of linkage and association much more difficult.  (+info)

(7/2366) The puzzle of autism: an ophthalmologic contribution.

PURPOSE: A previous study of 86 thalidomide-affected subjects with ophthalmic manifestations revealed the unexpected finding of autism in 4 of the 5 severely retarded individuals. The subjects had anomalies associated with an early gestational effect of thalidomide, including facial nerve palsy and incomitant strabismus. Because autism has been observed in a few cases of Mobius sequence (Mobius syndrome), a condition characterized by involvement of the sixth and seventh cranial nerves, the similarity to early thalidomide embryopathy suggested a relation between cranial nerve involvement and autism. The present study was undertaken to further evaluate the association of autism with patients manifesting findings of Mobius syndrome. METHODS: A prospective study of 25 Swedish patients with Mobius sequence was conducted. The patients had a complete multidisciplinary evaluation, including ophthalmologic and psychiatric examinations and standard testing for autism. Findings associated with autism were compared with the ocular and systemic anomalies of the 4 thalidomide-affected subjects. RESULTS: In the Mobius group 6 patients had autism, achieving the criteria for autism according to all the diagnostic manuals that were used. One patient showed autistic-like conditions meeting fewer numbers of the criteria. A few were too young to be meeting evaluated. Incomitant strabismus ranging from primary abduction defects alone to a horizontal gaze paresis pattern was noted in these patients, in addition to characteristic findings of seventh nerve paresis. Aberrant lacrimation was observed in many cases, especially often associated with autism. CONCLUSION: The common group of anomalies noted in both cases of thalidomide embryopathy and Mobius sequence suggests that brain-stem damage probably early in embryogenesis can sometimes be associated with autism.  (+info)

(8/2366) Spatial attention deficits in patients with acquired or developmental cerebellar abnormality.

Recent imaging and clinical studies have challenged the concept that the functional role of the cerebellum is exclusively in the motor domain. We present evidence of slowed covert orienting of visuospatial attention in patients with developmental cerebellar abnormality (patients with autism, a disorder in which at least 90% of all postmortem cases reported to date have Purkinje neuron loss), and in patients with cerebellar damage acquired from tumor or stroke. In spatial cuing tasks, normal control subjects across a wide age range were able to orient attention within 100 msec of an attention-directing cue. Patients with cerebellar damage showed little evidence of having oriented attention after 100 msec but did show the effects of attention orienting after 800-1200 msec. These effects were demonstrated in a task in which results were independent of the motor response. In this task, smaller cerebellar vermal lobules VI-VII (from magnetic resonance imaging) were associated with greater attention-orienting deficits. Although eye movements may also be disrupted in patients with cerebellar damage, abnormal gaze shifting cannot explain the timing and nature of the attention-orienting deficits reported here. These data may be consistent with evidence from animal models that suggest damage to the cerebellum disrupts both the spatial encoding of a location for an attentional shift and the subsequent gaze shift. These data are also consistent with a model of cerebellar function in which the cerebellum supports a broad spectrum of brain systems involved in both nonmotor and motor function.  (+info)



  • ADHD
  • However I have heard of many cases where dual diagnoses of a PDD disorder and ADHD have been given or PDD symptoms have been entirely overlooked and the individuals incorrectly diagnosed as having ADHD only. (autismuk.com)
  • whom
  • N -acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. (longecity.org)