Aspartame: Flavoring agent sweeter than sugar, metabolized as PHENYLALANINE and ASPARTIC ACID.Sweetening Agents: Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)Dipeptides: Peptides composed of two amino acid units.Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.Stevia: A plant genus of the family ASTERACEAE. Members contain stevioside and other sweet diterpene glycosides. The leaf is used for sweetening (SWEETENING AGENTS).Sodium Glutamate: One of the FLAVORING AGENTS used to impart a meat-like flavor.Taste: The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.Food Additives: Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.Sucrose: A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.Taste Threshold: The minimum concentration at which taste sensitivity to a particular substance or food can be perceived.Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.Cyclamates: Salts and esters of cyclamic acid.

*  sweeteners | Health Topics |
Does Aspartame Cause Cancer?. How should we parse the conflicting human data on aspartame (Nutrasweet) intake and non-Hodgkin's ... Aspartame & the Brain The reason artificially sweetened beverages have been associated with depression may be because of ... Aspartame & the Brain. The reason artificially sweetened beverages have been associated with depression may be because of ... Aspartame-Induced Fibromyalgia Case reports of fibromyalgia chronic pain sufferers cured, by removing the artificial sweetener ...
*  Aspartame: Good or Bad?
Aspartame is an artificial sweetener used in many foods. Its health effects are highly controversial, and this article examines ... Claim: Aspartame Causes Weight Gain. As a low-calorie sweetener, aspartame is commonly consumed by people who want to enjoy the ... Claim: Aspartame Causes Seizures. A few small studies have investigated the effects of aspartame on seizures. Most of them ... Aspartame is an artificial sweetener, often denoted as E951.. Originally sold under the brand name NutraSweet, aspartame was ...
*  Ketosis & Aspartame | LIVESTRONG.COM
Aspartame, Ketogenic Diets and Health. Both aspartame and ketogenic diets have been known to pose health risks. In an August 4 ... Aspartame and Ketosis. Aspartame is a calorie-free artificial sweetener found in diet soft drinks and other sugar-free products ... Before you add another spoonful of aspartame to your coffee or chug another diet soda, however, consider aspartame's impact on ... Joseph Mercola blasts aspartame as a deadly neurotoxin, citing episodes from its hard-won battle for U.S. Food and Drug ...
*  Aspartame
Okay, so most consumers concerned with their health have recognized the problem with Aspartame. No problem. Just try a few ... Note: In some countries such as Australia, the word "aspartame" may not appear on the label, but the phrase "Phenylketonurics: ... But it is still important to check labels as some health food stores are unknowingly selling aspartame, acesulfame-k, and ... Conclusion: 'While it is unlikely that sucralose is as toxic as the poisoning people are experiencing from Monsanto's aspartame ...
*  Toxic Sweetener: All About Aspartame
ASPARTAME. An artificial sweetener, it's one of the two most commonly used food additives in the products you buy from the ... Avoid Aspartame. The fact is, aspartame is not something that should be in our food. It does not occur naturally in food and ... But aspartame doesn't offer any of the same protection - at all.. Detoxify This. In order for your body to detoxify the wood ... Unfortunately, aspartame also accounts for over 75% of negative reactions to food additives reported to the U.S. Food and Drug ...
*  Aspartame
My aunt is diabetic and found she can't have aspartame. It swelled her joints and has caused her no end of hurt, and I refuse ... aspartame.. I'm not saying that aspartame is absolutely safe in any and all amounts,. just that it has NOT been linked to any ... Aspartame, is an amino acid. When it is taken in its' free form as in Aspartame,. ( unbound to proteins ), it significantly ... Aspartame- Budget101 Discussion List. My aunt is diabetic and found she can't have aspartame. It swelled her joints and has ...
*  Aspartame & Muscle Cramps | LIVESTRONG.COM
... should avoid aspartame. People with PKU cannot break down phenylalanine, which is one of the byproducts of aspartame in your ... Aspartame is also used as a powdered sweetener by diabetics and other individuals trying to cut down on calories and sugar. ... Only consume aspartame within the acceptable amounts, and read food labels to check which of the foods you are eating contain ... Aspartame is also considered safe if you have diabetes, because it does not contain carbohydrates and will not raise your blood ...
*  Aspartame-Cancer Link Exposed: Increasing Your ...
... with recent research revealing how various cancers are triggered by aspartame and diet soda.
'One can of diet soda each ... It seems the aspartame-cancer link has been exposed...again, ... It seems the aspartame-cancer link has been exposed...again, ... with recent research revealing how various cancers are triggered by aspartame and diet soda.. ...
*  Evaluation of Consumer Complaints Related to Aspartame Use
FDA had received about consumption of aspartame-containing products. The request followed an increase in aspartame-related ... aspartame and onset of symptoms often were incomplete because aspartame consumption was part of the daily routine. ... where the possibility of aspartame use leading to illness received particularly extensive press coverage. Although aspartame- ... As far as is known, complaints, such as those reported in this analysis as being related to aspartame use, have not been ...
*  WARNING! Aspartame (Nutrasweet) Labelling Need
... Sandra L Wegert sandraw at U.Arizona.EDU Sun Nov 12 17:12:53 EST 1995 *Previous ... These people need to know what preparations contain aspartame, so they can , stay away from it. This is a sound basis for ...
*  The Truth about Aspartame - The Green Guide
The Truth about Aspartame. January 8, 2014 Roberta Food, News 0 Have you ever heard the term aspartame? It sounds weird and it ... don't have exceeding levels of aspartame in their blood. Does that mean aspartame is healthy? Should we not be worried then? To ... Aspartame was first discovered in 1965, but it was several years later when FDA finally provided an approval of its use in ... Clearly, aspartame has its own pros and cons. One, it is definitely a helpful substance in mimicking the real taste of sugar ...
*  Where does aspartame come from? |
Aspartame is a noncaloric synthetic sweetener found in many soft drinks, and it is formed by combining the amino acids ... Aspartame is a noncaloric synthetic sweetener found in many soft drinks, and it is formed by combining the amino acids ... Aspartame was originally discovered by the American chemical company Searle in 1965. The sweetener then gained approval from ... Despite these approvals, there have been many questions over the health risks associated with aspartame since that time. Some ...
*  Aspartame in Baby Formula?!, page 1
Aspartame. No vanillin. That is the culprit, no? So which is it. Vanillin OR aspartame? You say yourself it "MIGHT" be an ... There is nothing out there that officially states that Vanillin is aspartame, or has aspartame in it, (well, there wouldn't be ... someone told me aspartame was actually a glue for the space shuttle ? Is that true? I've been hearing all the stuff about how ... Why no outcry about water? I'm sure you are as concerned about water and aspartame being mixed together? Why not? hidden or not ...
*  milk aspartame
You are here: Home / Archives for milk aspartame. NHT News. Vol. 9 No. 1 March 2013. NATURAL HEALTH TECHNIQUES NEWSLETTER Dr. ... Moffat: Newsletter going for 9 years now! Health in the News: Milk industry asking to hide aspartame in dairy products; Chicken ...
*  Victory Over Aspartame In California - Prop 65
... opinion on aspartame by Mark Gold, Aspartame Toxicity Center. Here is the ... Until aspartame is banned the lies will continue because a poison is never safe. The FDA tried to prevent approval but today ... About six years ago aspartame was banned in Romania because it was causing so much cancer. It's past time to do the same in the ... Don Rumsfeld got aspartame approved by political chicanery, in conjunction with his hand picked stooge, Dr. Arthur Hull Hayes, ...
*  Aspartame Is An Excitoneurotoxic Carcinogenic Drug!
The control animals, which received no aspartame, developed no brain tumors, whereas the aspartame exposed animals developed 10 ... In 1974 aspartame was approved for use only in dry foods. Its approval was based on these studies. Yet, even before these ... Aspartame Is An Excitoneurotoxic Carcinogenic Drug!. 2006 03 18. By Russell L. Blaylock, MD , ... Dangers of Aspartame. In 1965, a researcher at G.D. Searle pharmaceutical company inadvertently discovered the artificial ...
*  The Truth About Aspartame Toxicity & Nancy Markle
... Return to. Aspartame (NutraSweet) Toxicity Information Center. A "World ... "The animals were given high doses of aspartame". A. The metabolites of aspartame are anywhere from 5 to 60 times more toxic in ... Aspartame is a dipeptide, but breaks down into the following chemicals: methanol (wood alchol) -- whether aspartame is heated ... "Methanol levels do not rise after aspartame ingestion.". A. The aspartame manufacturers funded 13 years of studies where a ...
*  Aspartame | GreenMedInfo | Toxic Ingredient | Natural Medicine
This topic contains 28 study abstracts on Aspartame indicating it may contribute to Fibromyalgia, Excitotoxicity, and Urinary ... 3 Abstracts with Aspartame & Excitotoxicity Research. [x] Remove Focus on Excitotoxicity Filter by Study Type. Animal Study. ... Problem Substances : Aspartame, Brilliant Blue FCF, L-glutamic Acid, Quinoline Yellow. Adverse Pharmacological Actions : ... Will aspartame in our milk be the new attractive 'diet' drink? The latest debate with letting you know what is in the food ...
*  Dangers of Aspartame
I have spent several days lecturing at the WORLD ENVIRONMENTAL CONFERENCE on ASPARTAME marketed as NutraSweet, Equal, and ... contains aspartame black to the store. Take the 'NO ASPARTAME TEST' and. send us your case history.. Aspartame Disease is ... aspartame. The aspartame keeps the blood sugar level out of control,. causing many patients to go into a coma. Unfortunately, ... identical to aspartame poisoning. Dr. Roberts says 'consuming aspartame at. the time of conception can cause birth defects'. ...
*  Scientific Abuse in Seizure Research Related to Aspartame
Aspartame and Nutrasweet research abuse from Monsanto. This page is specific to the abuse of the research related to seizures ... "Reported Aspartame Toxicity Effects" (Referenced Analysis of Reported Toxicity From Aspartame and Reporting Rate). Aspartame ( ... Aspartame Industry Pumps Out Its Own Animal Research *References Summary of Aspartame-Induced Seizures Issue. As of 1995 more ... Back to Aspartame Scientific Abuse Main Page Back to Aspartame Toxicity Information Center. Table of Contents. *Summary of ...
Tel: 416-754-2004 - E-mail: - Web site: DISABILITY AND DEATH ARE NOT ACCEPTABLE COSTS ... Use of Aspartame By Pharmaceutical Companies. Aspartame is not only used in food, per se, but is also used in pharmaceutical ... ASPARTAME - THE SILENT KILLER. Return to Subject Index - Main Index. (Made by Monsanto, the world's largest manufacturer of ... Aspartame is banned in all childrens products in the European Common Market. Why not here? Is not the life, health and safety ...
*  Doubts persist on aspartame safety - tribunedigital-baltimoresun
Approval of aspartame in carbonated beverages followed in July 1983.. Hundreds of aspartame studies have been performed. Dave ... Aspartame seems a particularly popular topic for aviation magazines.. Charles King, a part-time pilot who owns a grocery store ... Aspartame, approved by the FDA in 1981, came under fire almost immediately. Citing cases like Mr. Taylor's and a number of ... Aspartame was certified in 1974, but production stopped when complaints of sloppy research prompted an investigation into ...
*  aspartame cessation == feeling better -
aspartame cessation == feeling better I was having heart palpitations very regularly. I was drinking at least one diet soda/day ... Aspartame definatley keeps me awake at night. I can't take casein before bed coz I can't find any that doesn't have any ... I am sure most people are not like me and they are totally fine consuming aspartame, but I just wanted to post this to see if ... I honestly thought all the 'aspartame is poison' talk was a bunch of crap, but after this experience I am probably done with it ...
*  Gum Containing Aspartame
These are the chewing gums that contain Aspartame in them and should be avoided. Some health information is included, but your ... The ingredient of Aspartame is now in the Juicy Fruit gum. Aspartame has been tested on rats to produce tumors, epilepsy and ... Trident contains Aspartame in the chewing gum sold in the United States. The health effects of Aspartame have been assorted in ... Don't stop thinking all the other chewing gum is Aspartame free because it is not. Read the labels and look for that Aspartame ...

AspartameSweetness: Sweetness is one of the five basic tastes and is universally regarded as a pleasurable experience, except perhaps in excess. Foods rich in simple carbohydrates such as sugar are those most commonly associated with sweetness, although there are other natural and artificial compounds that are sweet at much lower concentrations, allowing their use as non-caloric sugar substitutes.Dipeptide: A dipeptide is a sometimes ambiguous designation of two classes of organic compounds: Its molecules contain either two amino acids joined by a single peptide bond or one amino acid with two peptide bonds.Phenylalanine N-monooxygenase: Phenylalanine N-monooxygenase (, phenylalanine N-hydroxylase, CYP79A2) is an enzyme with system name L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reactionStevia: Stevia (, or )Both and are recorded by at least some US and UK dictionaries, but the former is more common in US English (listed first or exclusively) and the latter is more common in UK English. is a sweetener and sugar substitute extracted from the leaves of the plant species Stevia rebaudiana.Kikunae Ikeda: was a Japanese chemist and Tokyo Imperial University professor of Chemistry who, in 1908, uncovered the chemical basis of a taste he named umami. It is one of the five basic tastes along with sweet, bitter, sour and salty.Taste: Taste, gustatory perception, or gustationAdjectival form: [is the sensory impression of food] or other substances on the tongue and is one of the [[sense|five traditional senses.E350 (food additive): E350 is an EU recognised food additive. It comes in two forms,Sucrose gap: The sucrose gap technique is used to create a conduction block in nerve or muscle fibers. A high concentration of sucrose is applied to the extracellular space to increase resistance between two groups of cells, which prevents the correct opening and closing of sodium and potassium channels.Electrogustometry: Electrogustometry is the measurement of taste threshold by passing controlled anodal current through the tongue. When current passes through the tongue a unique and distinct metallic taste is perceived.Assugrin

(1/86) Interaction of nucleotides with Asp(351) and the conserved phosphorylation loop of sarcoplasmic reticulum Ca(2+)-ATPase.

The nucleotide binding properties of mutants with alterations to Asp(351) and four of the other residues in the conserved phosphorylation loop, (351)DKTGTLT(357), of sarcoplasmic reticulum Ca(2+)-ATPase were investigated using an assay based on the 2', 3'-O-(2,4,6-trinitrophenyl)-8-azidoadenosine triphosphate (TNP-8N(3)-ATP) photolabeling of Lys(492) and competition with ATP. In selected cases where the competition assay showed extremely high affinity, ATP binding was also measured by a direct filtration assay. At pH 8.5 in the absence of Ca(2+), mutations removing the negative charge of Asp(351) (D351N, D351A, and D351T) produced pumps that bound MgTNP-8N(3)-ATP and MgATP with affinities 20-156-fold higher than wild type (K(D) as low as 0.006 microM), whereas the affinity of mutant D351E was comparable with wild type. Mutations K352R, K352Q, T355A, and T357A lowered the affinity for MgATP and MgTNP-8N(3)-ATP 2-1000- and 1-6-fold, respectively, and mutation L356T completely prevented photolabeling of Lys(492). In the absence of Ca(2+), mutants D351N and D351A exhibited the highest nucleotide affinities in the presence of Mg(2+) and at alkaline pH (E1 state). The affinity of mutant D351A for MgATP was extraordinarily high in the presence of Ca(2+) (K(D) = 0.001 microM), suggesting a transition state like configuration at the active site under these conditions. The mutants with reduced ATP affinity, as well as mutants D351N and D351A, exhibited reduced or zero CrATP-induced Ca(2+) occlusion due to defective CrATP binding.  (+info)

(2/86) On the sweetness of N-(trifluoroacetyl)aspartame.

A panel of tasters has found that the N-trifluoroacetyl derivative of aspartame is five times less sweet than the parent compound, contrary to the tenet in the literature, but consistent with sweet receptor models which require this nitrogen to exist in protonated form.  (+info)

(3/86) Genetic taste responses to 6-n-propylthiouracil among adults: a screening tool for epidemiological studies.

Genetically mediated taste responsiveness to 6-n-propylthiouracil (PROP) has been linked to reduced acceptance of some bitter foods. In this community-based study male (n = 364) and female (n = 378) adults enrolled in a self-help dietary intervention trial were screened for PROP taster status. Respondents, aged 18--70 years, were mailed filter papers impregnated with PROP or with aspartame solutions. They received instructions to rate taste intensity and hedonic preference using nine point category scales. Women rated PROP as more bitter than did men. Both sweetness and bitterness ratings were lower for older adults. Taste responsiveness to PROP was unrelated to body mass index in women or men. Higher bitterness ratings for PROP were weakly associated with higher sweetness ratings for aspartame, but were unrelated to sweet taste preferences. Successful administration of PROP filter papers by mail suggests new avenues for the screening of taste phenotypes in epidemiological studies.  (+info)

(4/86) Whole nerve chorda tympani responses to sweeteners in C57BL/6ByJ and 129P3/J mice.

The C57BL/6ByJ (B6) strain of mice exhibits higher preferences than does the 129P3/J (129) strain for a variety of sweet tasting compounds. We measured gustatory afferent responses of the whole chorda tympani nerve in these two strains using a broad array of sweeteners and other taste stimuli. Neural responses were greater in B6 than in 129 mice to the sugars sucrose and maltose, the polyol D-sorbitol and the non-caloric sweeteners Na saccharin, acesulfame-K, SC-45647 and sucralose. Lower neural response thresholds were also observed in the B6 strain for most of these stimuli. The strains did not differ in their neural responses to amino acids that are thought to taste sweet to mice, with the exception of L-proline, which evoked larger responses in the B6 strain. Aspartame and thaumatin, which taste sweet to humans but are not strongly preferred by B6 or 129 mice, did not evoke neural responses that exceeded threshold in either strain. The strains generally did not differ in their neural responses to NaCl, quinine and HCl. Thus, variation between the B6 and 129 strains in the peripheral gustatory system may contribute to differences in their consumption of many sweeteners.  (+info)

(5/86) Application of the U and gamma' models in binary sweet taste mixtures.

The U and Gamma' models of sensory interactions, successfully applied in olfaction for several years, are tested here using data from published studies on sweetness. The models are subsequently tested on new data obtained in studies of binary mixtures of four sodium sulfamates. The U model allows for the estimation of a global interaction, whereas the Gamma' model allows for the distinction between that which is due to an intrinsic interaction in the mixture itself and that which may be due to the power function exponents in the mixture. The models give satisfactory predictions for observed phenomena of sweet taste suppression, synergism or pure additivity. Additionally, they appear to be more suitable than other models recently applied in taste, particularly the equiratio model. Application of the models to the sulfamate mixtures, reveals additivity for sodium cyclohexylsulfamate (cyclamate)/potassium cyclohexylsulfamate and sodium cyclohexylsulfamate/sodium exo-2-norbornylsulfamate, respectively; whereas for sodium cyclohexylsulfamate/sodium 3-bromophenylsulfamate, the models revealed a slight hypo addition which is simply due to the dissimilarity values of the power function exponents of the components.  (+info)

(6/86) The effect of various substances on the suppression of the bitterness of quinine-human gustatory sensation, binding, and taste sensor studies.

The purpose of this study was to quantify the degree of suppression of the perceived bitterness of quinine by various substances and to examine the mechanism of bitterness suppression. The following compounds were tested for their ability to suppress bitterness: sucrose, a natural sweetener; aspartame, a noncaloric sweetener; sodium chloride (NaCl) as the electrolyte; phosphatidic acid, a commercial bitterness suppression agent; and tannic acid, a component of green tea. These substances were examined in a gustatory sensation test in human volunteers, a binding study, and using an artificial taste sensor. Sucrose, aspartame, and NaCl were effective in suppressing bitterness, although at comparatively high concentrations. An almost 80% inhibition of bitterness (calculated as concentration %) of a 0.1 mM quinine hydrochloride solution required 800 mM of sucrose, 8 mM of aspartame, and 300 mM NaCl. Similar levels of bitterness inhibition by phosphatidic acid and tannic acid (81.7, 61.0%, respectively) were obtained at much lower concentrations (1.0 (w/v)% for phosphatidic acid and 0.05 (w/v)% for tannic acid). The mechanism of the bitterness-depressing effect of phosphatidic acid and tannic acid was investigated in terms of adsorption and masking at the receptor site. With phosphatidic acid, 36.1% of the bitterness-depressing effect was found to be due to adsorption, while 45.6% was due to suppression at the receptor site. In the case of 0.05 (w/v)% tannic acid, the total bitterness-masking effect was 61.0%. The contribution of the adsorption effect was about 27.5% while the residual masking effect at the receptor site was almost 33%. Further addition of tannic acid (0.15 (w/v)%), however, increased the bitterness score of quinine, which probably represents an effect of the astringency of tannic acid itself. Finally, an artificial taste sensor was used to evaluate or predict the bitterness-depressing effect. The sensor output profile was shown to reflect the depressant effect at the receptor site rather well. Therefore, the taste sensor is potentially useful for predicting the effectiveness of bitterness-depressant substances.  (+info)

(7/86) Formaldehyde-induced shrinkage of rat thymocytes.

To test the possibility that micromolar formaldehyde, a metabolite of methanol derived from aspartame, exerts cytotoxicity, its effect on rat thymocytes was examined under the in vitro condition using a flow cytometer. Incubation of thymocytes with formaldehyde at 100 micro M or more for 24 h significantly increased the populations of shrunken cells and cells with hypodiploid DNA. The peak blood concentration of methanol in human subjects administered abuse doses of aspartame has been reported to exceed 2 mg/dL (625 micro M). It would increase the population of thymocytes undergoing apoptosis if formaldehyde at 100 micro M or more appears in the blood after administration of aspartame.  (+info)

(8/86) Modified DNA aptamers against sweet agent aspartame.

We obtained a modified DNA aptamer against sweetener, aspartame, by in vitro selection method. The modified DNA was prepared from dATP, dGTP, dCTP and a modified dTTP bearing a terminal amino group at C-5 position in place of thymidine by PCR using a hyper thermophilic DNA polymerase, KOD Dash DNA polymerase. The synthetic 102-mer DNA with a 60-mer random region was used as an initial template for the PCR. The PCR-amplified modified DNA library was applied to an aspartame-agarose column, and then the bound modified DNA was eluted from the column for the affinity chromatography selection. Repeating the procedure, we selected the modified DNA aptamer against aspartame.  (+info)

  • saccharin
  • People were telling us at the Conference of the American College of Physicians, that they had relatives that switched from saccharin to an aspartame product and how that relative had eventually gone into a coma. (
  • In products that may require a longer shelf life, such as syrups for fountain beverages, aspartame is sometimes blended with a more stable sweetener, such as saccharin. (
  • consumption
  • Any health effects from aspartame consumption are caused by these compounds, which are absorbed into the blood. (
  • In February 1984, the U.S. Food and Drug Administration (FDA) requested CDC's assistance in evaluating consumer complaints that FDA had received about consumption of aspartame-containing products. (
  • Criteria originally developed to assess potential adverse reactions to medications were adapted to evaluate the likelihood that symptoms reported by individuals through this passive surveillance system could be due to aspartame consumption (1,2). (
  • Evaluation of dose-response relationships might have been fruitful had individuals reported symptoms with increasingly high consumption of aspartame-containing products. (
  • Before we move on to the possible adverse effects that this product can bring to the body, it should be known that FDA allows a person's consumption of aspartame to no more than 50 milligrams. (
  • A panel of experts set up by the European Food Safety Authority concluded in 2013 that aspartame is safe for human consumption at current levels of exposure. (
  • Reviews by governmental regulatory bodies have found aspartame safe for consumption at current levels. (
  • Aspartame has been deemed safe for human consumption by over 100 regulatory agencies in their respective countries, including the UK Food Standards Agency, the European Food Safety Authority (EFSA) and Health Canada. (
  • Two 2017 systematic review and meta-analysis found that aspartame consumption had no significant effect on variables related to obesity and diabetes. (
  • Searle
  • Aspartame was originally discovered by the American chemical company Searle in 1965. (
  • In 1965, a researcher at G.D. Searle pharmaceutical company inadvertently discovered the artificial sweetener aspartame while working on an anti-ulcer medication. (
  • The controversy over aspartame safety originated in perceived irregularities in the aspartame approval process during the 1970s and early 1980s, including allegations of a revolving door relationship between regulators and industry and claims that aspartame producer G.D. Searle had withheld and falsified safety data. (
  • Searle had submitted 168 studies on aspartame, including seven animal studies that were considered crucial by the FDA. (
  • In December 1975, the FDA placed a stay on the aspartame approval, preventing Searle from marketing aspartame. (
  • In 1977 and 1978, an FDA task force and a panel of academic pathologists reviewed 15 aspartame studies by Searle, and concluded that, although there were major lapses in quality control, the resulting inconsistencies would not have affected the studies' conclusions. (
  • food additive
  • The study notes that patients with a chronic pain disorder called fibromyalgia, or FM, showed improved symptoms after completely removing aspartame and a food additive called monosodium glutamate, or MSG, from their diet. (
  • In 1987, the U.S. Government Accountability Office concluded that the food additive approval process had been followed properly for aspartame. (
  • With the exception of the risk to those with phenylketonuria, aspartame is considered to be a safe food additive by governments worldwide and major health and food safety organizations. (
  • methanol produced
  • The methanol produced during the digestion of aspartame is only a small part of the total dietary intake. (
  • However, although it appears credible, the claims made in the email are a complete fabrication, and statements about the toxicity of methanol produced by aspartame metabolism rely on ignoring the small amounts produced by this process. (
  • 1981
  • The 1974 approval was withdrawn and after the results of these investigations were reviewed privately, aspartame was given approval once again in 1981. (
  • beverages
  • Aspartame was first discovered in 1965 , but it was several years later when FDA finally provided an approval of its use in carbonated drinks, beverages, and foods. (
  • The NSDA wrote a 33 page protest against using aspartame in carbonated beverages, then turned around and lobbied for the manufacturer. (
  • Aspartame (APM) is an artificial non-saccharide sweetener used as a sugar substitute in some foods and beverages. (
  • In products such as powdered beverages, the amine in aspartame can undergo a Maillard reaction with the aldehyde groups present in certain aroma compounds. (
  • toxicity
  • The World Environmental Conference did occur with an EPA representative speaking and the discussion turning to aspartame toxicity. (
  • A short summary of the aspartame toxicity issue will be presented below. (
  • An enormous number of people have reported serious toxicity reactions from extended use of aspartame including seizures, vision loss, neuropathy symptoms, loss of blood sugar control, nausea, memory loss, depression, and other signs of gradual damage to the body's neurological and immunological systems. (
  • As of 1995 more than 7% of the aspartame toxicity reactions reports sent to the U.S. Food and Drug Administration (FDA) involve seizures and convulsions (DHHS 1995). (
  • The FDA stopped accepting aspartame toxicity reaction reports in 1995 (Food 1995). (
  • In addition, the FDA told its regional offices to not report aspartame toxicity reactions to the Washington, D.C. headquarters (CNI 1984). (
  • seizures
  • Other concerns of aspartame include headache pain, seizures, mood changes and weight gain, but reports that research has shown that aspartame does not increase the risk of these health concerns. (
  • In a study looking at 551 aspartame reactors, Roberts (1988) found that grand mal, petit mal, and absence seizures occurred in 18% of the cases. (
  • In 1986, Food and Chemical News reported that 80 cases of aspartame-induced seizures had been reported to Dr. Richard Wurtman at M.I.T. (Food 1986). (
  • Walton (1986, 1988) published reports of nine cases of seizures linked to aspartame use. (
  • The hypothesis is that this change in brain chemistry will lead to a lowering of the seizure threshold and persons ingesting aspartame will become more susceptible to having seizures. (
  • Tollefson inappropriately classified seizures as "Group D -- highly unlikely" related to aspartame if the subjects refused to release their medical records. (
  • Searle's
  • U.S. Attorney Samuel Skinner was requested to "open a grand jury investigation into whether two of Searle's aspartame studies had been falsified or were incomplete. (
  • sugar
  • As a sugar substitute, aspartame stimulates the taste buds on the tongue in the same way as sugar. (
  • As a low-calorie sweetener, aspartame is commonly consumed by people who want to enjoy the sweetness but need to limit their sugar intake. (
  • Aspartame is also used as a powdered sweetener by diabetics and other individuals trying to cut down on calories and sugar. (
  • Unlike sugar, aspartame does not raise your blood sugar levels when ingested. (
  • Aspartame is also considered safe if you have diabetes, because it does not contain carbohydrates and will not raise your blood glucose or sugar levels. (
  • Additionally, aspartame will not contribute to dental decay because it does not contain sugar. (
  • In fact, studies show that even diabetics, people who are high in blood sugar level, which is most likely caused by abnormal intake of sugar, don't have exceeding levels of aspartame in their blood. (
  • In one lecture attended by the Ambassador of Uganda, he told us that their sugar industry is adding aspartame! (
  • The aspartame keeps the blood sugar level out of control, causing many patients to go into a coma. (
  • The PUR Company Inc. uses the slogan "Kick Aspartame" to promote their sugar-free and aspartame-free products. (
  • unbound
  • When it is taken in its' free form as in Aspartame, ( unbound to proteins ), it significantly raises the blood plasma levels of Aspartate. (
  • European Food Safe
  • The testimony of the Center for Science in the Public Interest was helpful in that they knew of the misinformation of the European Food Safety Authority review that sugarcoated aspartame as "safe" and warned not to consider it. (
  • amino
  • Like many other peptides, aspartame may hydrolyze (break down) into its constituent amino acids under conditions of elevated temperature or high pH. (
  • commonly
  • As far as is known, complaints, such as those reported in this analysis as being related to aspartame use, have not been commonly reported in other countries in which aspartame is also in use. (
  • lupus
  • In the cases of systemic lupus, which is triggered by ASPARTAME, the victim usually does not know that the aspartame is the culprit The victim continues its use aggravating the lupus to such a degree, that sometimes it becomes life threatening. (
  • When we get people off the aspartame, those with systemic lupus usually become asymptomatic. (
  • Numerous websites have spread the email's claims, which were not backed by scientific evidence, about safety issues purportedly linked to aspartame, including Gulf War Syndrome and lupus. (
  • In 1998 an email began circulating claiming that aspartame, an artificial sweetener, caused many chronic diseases, including multiple sclerosis and lupus. (
  • amounts
  • As aspartame is digested, low amounts of methanol are formed. (
  • I'm not saying that aspartame is absolutely safe in any and all amounts, just that it has NOT been linked to any diseases yet. (
  • When ingested into your body, aspartame may signal the nerves in this system to release high amounts of neurotransmitter or chemical messengers that cause muscle contraction and cramping. (
  • symptoms
  • The quality and type of evidence that may be obtained by a passive surveillance system does not allow definitive determination of whether given symptoms are or are not caused by the agent under question--in this case, aspartame. (
  • An important criterion in assessing potential adverse reactions is the consistency of reported symptoms with rechallenge, i.e., the recurrence of symptoms after consuming aspartame-containing products a second time. (
  • rats
  • A member of the CIC committee mentioned the rats had infections as relates to the Ramazzini Studies which proved aspartame is a multipotential carcinogen. (
  • Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation. (
  • negligible
  • Due to this property, even though aspartame produces four kilocalories of energy per gram (17 kJ/g) when metabolized, the quantity of aspartame needed to produce a sweet taste is so small that its caloric contribution is negligible. (