Aspartame: Flavoring agent sweeter than sugar, metabolized as PHENYLALANINE and ASPARTIC ACID.Sweetening Agents: Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)Dipeptides: Peptides composed of two amino acid units.Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.Stevia: A plant genus of the family ASTERACEAE. Members contain stevioside and other sweet diterpene glycosides. The leaf is used for sweetening (SWEETENING AGENTS).Sodium Glutamate: One of the FLAVORING AGENTS used to impart a meat-like flavor.Taste: The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.Food Additives: Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.Sucrose: A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.Taste Threshold: The minimum concentration at which taste sensitivity to a particular substance or food can be perceived.Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.Cyclamates: Salts and esters of cyclamic acid.

*  Sweet Misery: Aspartame Dangers

Sweet Misery: A Poisoned World': A Compelling Documentary that Exposes the Real Dangers of Aspartame and How it Became FDA ... movie is that in a shot ninety minutes you will easily in the relaxed comfort of your home finally understand why aspartame is ...
https://organicconsumers.org/news/sweet-misery-aspartame-dangers

*  Coca-Cola aspartame ad defends use of the artificial sweetner - UPI.com

Coca-Cola defends its use of aspartame in new print ad. ... Coca-Cola aspartame ad defends use of the artificial sweetner ... "Our use of high-quality, low- and no- calorie sweeteners, including aspartame, allows us to give people great-tasting options ... The company particularly defended its use of aspartame -- composed of aspartic acid and phenylalanine -- claiming its safety ...
upi.com/Science_News/Blog/2013/08/14/Coca-Cola-aspartame-ad-defends-use-of-the-artificial-sweetner/8321376503745/?spt=mps&or=1

*  Lemonade, low calorie, with aspartame, powder, prepared with water Nutrition

... with aspartame, powder, prepared with water Nutrition - BellaOnline Nutrition Database - BellaOnline is committed to helping ... Lemonade, low calorie, with aspartame, powder, prepared with water Nutrition Information - Full Details. All values shown in ... Lemonade, low calorie, with aspartame, powder, prepared with water. Food Group: Beverages. Long Description: Lemonade, low ... This page is all about the nutrition of Lemonade, low calorie, with aspartame, powder, prepared with water. Learn about the ...
bellaonline.com/nutrition/detail.asp?id=14290&qty=2

*  Aspartame -- Artificial Sweetener

Aspartame is one of the sugar substitutes used by diabetics. Products containing aspartame usually have a warning label that ... While aspartame, like other peptides, has a caloric value of 4 kilocalories per gram, the quantity of aspartame needed to ... Aspartame.org (http://www.aspartame.org/) Info from a low-calorie Food & Beverage Industry-supported organization. *Aspartame ... The U.S. patent on aspartame expired in 1992, and the aspartame market is now hotly contested between the NutraSweet Company ...
edinformatics.com/inventions_inventors/aspartame.htm

*  How FDA Approved Aspartame

If you drink aspartame and have experienced health problems, then cease your consumption of it (and its cousin MSG) for 60 days ... who has Lou Gehrig's from aspartame in his paper Aspartame Murders Infants, Violates Federal Domestic Genocide Law: "Aspartame ... Beyond this, aspartame disrupts fetal development by aborting it or inducing defects. And if a live child is born, aspartame ... Regarding aspartame, I have written articles about this substance, they explained the processes that allowed aspartame into the ...
https://life-enthusiast.com/articles/how-fda-approved-aspartame

*  aspartame | Breaking Muscle AU

Studies on Aspartame Don't Tell the Whole Story. Aspartame has been widely vilified recently, but do you know why? Let's break ... aspartame. Why I'm Not Scared of Artificial Sweeteners I generally don't advise against the use of artificial sweeteners, and ... There are four main artificial sweeteners on the market today - saccharin, aspartame, sucralose, and stevia - each has their ... Archive of articles for the aspartame category ...
https://breakingmuscle.com/au/category/tags/aspartame

*  ChemPointcom to market aspartame | Food Business News

Home > News > ChemPointcom to market aspartame ChemPoint.com to market aspartame. May 06, 2009 - by FoodBusinessNews.net Staff ... has chosen ChemPoint.com as its exclusive North American channel partner for aspartame, a low-calorie sweetener. Bellevue-based ...
foodbusinessnews.net/news/news-home/business-news/2009/05/chempointcom-to-market-aspartame.aspx

*  China Aspartame Free Proteins Market 2017 Latest Report Available Online at Orbisresearch.com | Medgadget

China Aspartame Free ProteinsMarket Report: 2017 ' available with Single User China USD 3200 at OrbisResearch.com The Aspartame ... The Aspartame Free Proteins market report gives a detailed overview of the key segments in the market . Aspartame Free Proteins ... 2 China Aspartame Free Proteins and Growth Rate Forecast (2017-2022). 3 China Aspartame Free Proteins Revenue and Growth Rate ... The Aspartame Free Proteins Market report covers the present scenario and the growth prospects of the China Aspartame Free ...
https://medgadget.com/2017/03/china-aspartame-free-proteins-market-2017-latest-report-available-online-at-orbisresearch-com.html

*  I Try to Avoid Aspartame

Join friendly people sharing true stories in the I Try to Avoid Aspartame group. Find forums, advice and chat with groups who ... My Ode Entitled Aspartame Insane Aspartame: Insane Rots your Brain Found in Pepsi and Coca Cola And Robinson's Barley Water To ... It's so sneaky, has so many names (aspartame, E951, aspartic acid) and relatives that it's almost impossible to avoid it, but I ... Most recently it has been revealed that aspartame may be linked to autism in children. Warning pregnant women should abstain ...
experienceproject.com/groups/Try-To-Avoid-Aspartame/106703

*  Aspartame in Milk Without a Label? Big Dairy Petitions FDA For Approval

Aspartame in Milk Without a Label? Big Dairy Petitions FDA For Approval. TOPICS:Activist PostFDA ... They claim that aspartame and other artificial sweeteners would promote healthy eating and is good for school children. ... Although the FDA considers aspartame to be a "safe and suitable" sweetener, a recent Yale University study appears to directly ... To submit a formal comment or send data to the FDA concerning adding aspartame and other artificial sweeteners to milk products ...
https://activistpost.com/2013/02/aspartame-in-milk-without-label-big.html?showComment=1361736691341

*  Aspartame Manufacturers, Suppliers, Exporters,Dealers in India

Get Details of Aspartame Manufacturers,Aspartame Suppliers,Aspartame Dealers, Aspartame Exporters, Aspartame Traders, Aspartame Producers, Aspartame Wholesalers, Aspartame Companies
maharashtradirectory.com/product/aspartame.html

*  Sweetness Enhancement of Aspartame in the Presence of Cyclodextrins and the Thermodynamics in Binding Acta Phys Chim Sin

Current research on the effects of cyclodextrins (CDs) on the sweetness of aspartame (ASP) focuses on the stability of aspartame as protected by CDs. We propose a relationship between the sweetness intensity of aspartame and its thermodynamic binding affinity with CDs. In this paper, we describe the sensory evaluation of aspartame with the five CDs α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), and methyl-β-cyclodextrin (Met-β-CD). β-CD was found to significantly enhance the sweetness intensity of aspartame. The binding affinity of CDs with aspartame was then investigated using isothermal titration calorimetry (ITC) and fluorescence spectroscopy. The binding of aspartame with β-CD resulted in a free energy change with the largest binding constant. Differential scanning calorimetry (DSC), nuclear magnetic resonance (1H NMR), and ...
whxb.pku.edu.cn/EN/abstract/abstract29649.shtml

*  Aspartame - A Sweet Poison

A few years ago I was having lunch with a friend and she was telling me about the health issues she had been experiencing. She listed a number of symptoms-headaches, dizziness, irritability, and anxiety attacks which she contributed to the lack of medical answers. She had been to the doctor numerous times, had blood work as well as scans done, yet they found nothing that would contribute to the symptoms on her list.. Since she was drinking a diet soft drink at lunch, I suggested she look into the effects of an ingredient commonly found in diet soft drinks, Aspartame. If your fretting right now, you need to hear this.. Aspartame, also known as Equal or NutraSweet, has been linked to numerous health issues. Somehow this chemical made its way into society even though in 1980, the FDA Board of Inquiry (comprised of three independent scientists) confirmed that Aspartame "might induce brain tumors." The FDA actually banned aspartame based on this ...
faithandfood.org/aspartame-a-sweet-poison/

*  China Aspartame Powder/Granular 22839-47-0 - China C14h18n2o5, Aspartame Granular

China Aspartame Powder/Granular 22839-47-0, Find details about China C14h18n2o5, Aspartame Granular from Aspartame Powder/Granular 22839-47-0 - Henan Xingfa Bio-Technology Co., Ltd.
hnjzxf.en.made-in-china.com/product/rXvJDbRyEOcU/China-Aspartame-Powder-Granular-22839-47-0.html

*  Medicine Watch: Aspartame is safe, says new study

A new study which involved a review of more than 500 reports by an international panel from 10 universities and medical schools states that aspartame is safe. According to the study, there is no evidence that the sweetener causes cancer, neurological damage or other health problems in humans. Aspartame is sold under various brand names including Equal and NutraSweet and has few calories ...
medicinewatch.blogspot.com/2007/09/aspartame-is-safe-says-new-study.html

*  Get Fit 4 Living: Let's Talk Aspartame

Aspartame is L-apartyl, L-phenylalanine methyl ester. The three toxic ingredients of it are methanol, which is grain alcohol, phenylalaine and aspartic acid- the last two are amino acid isolates. Let me explain that: Proteins, needed for muscle development and repair, is made up of many amino acids grouped together. There are 22 amino acids necessary for normal human growth, with 14 of those that our body can make called non essential amino acids. Then, there are 8 other amino acids called essential amino acids that we must get from outside sources such as food. Amino acid isolates have been artificially separated from the protein chain and are now single or dipeptide molecules. Aspartic acid and phenylalanine are two types of genetically modified or manufactured amino acids. Because of this our body's metabolize them differently than amino acids that have not been broken apart or artificially made. You also need to know that the isolates of aspartame are incorporated into a ...
getfit4living.blogspot.com/2011/12/lets-talk-aspartame.html

*  TECHNOBABE'S ADVENTURES: Detox from Aspartame

Symptoms were: chest pain (even went to the ER), severe anxiety, joint pain traveling to different parts of my body, depression and feeling no energy, weakness, heart palpitations ( racing heart and skipped beats) If I had not gone to a blog a few weeks back - I would not believe it had been aspartame poisoning. But other people had similar symptoms. It was the most difficult thing I did in my life - even harder than giving up cigarattes. I would advise someone stopping aspartame to do it slowly. Talk with someone who can help you with it. My primary care doctor said she was aware of withdrawal symptoms but should not last that long. I will tell her to advise patients about it on my next visit. VERY BAD STUFF - SHOULD BE OFF THE MARKET. Good luck to anyone getting off it - your body will thank you. ...
thetechnobabe.blogspot.com/2008/06/detox-from-aspertame.html

*  Top 10 Must-Know Facts About the Sweetener Aspartame - NDTV Food

All my office colleagues who drink copious amounts of diet drinks without a care in the world for their health, are all looking at me with that I told you so look. The reason is the latest scientific studies thats been conducted on animals and humans.
food.ndtv.com/health/top-10-must-know-facts-about-the-sweetener-aspartame-694459

*  Nutrition Group Says Chocolate Milk Is OK, No Need For Aspartame - WNYC

A controversial petition by the dairy industry to allow milk sweetened with aspartame or other alternative sweeteners to be labeled ...
wnyc.org/story/294553-nutrition-group-says-chocolate-milk-is-ok-no-need-for-aspartame/

*  New Diet Pepsi: Same silver can, but no Aspartame, Consumer - THE BUSINESS TIMES

THE BUSINESS TIMES Consumer - [NEW YORK] Diet Pepsi made without aspartame is scheduled to hit shelves across the US on Monday, marking the biggest change to the beverage in three decades.. Read more at The Business Times.
businesstimes.com.sg/consumer/new-diet-pepsi-same-silver-can-but-no-aspartame

*  perihalbarah: FDA to approve aspartame as hidden

IDFA and NMPF argue that nutrient content claims such as "reduced calorie" are not attractive to children, and maintain that consumers can more easily identify the overall nutritional value of milk products that are flavored with non-nutritive sweeteners if the labels do not include such claims. Further, the petitioners assert that consumers do not recognize milk -- including flavored milk -- as necessarily containing sugar. Accordingly, the petitioners state that milk flavored with non-nutritive sweeteners should be labeled as milk without further claims so that consumers can "more easily identify its overall nutritional value." ...
perihalbarah.blogspot.com/2013/04/fda-to-approve-aspartame-as-hidden.html

*  What Are the Side Effects of Phenylalanine & Aspartame? | LIVESTRONG.COM

Phenylalanine is an essential amino acid and safe for everyone except those who have a condition called phenylketonuria, or PKU. This amino acid, combined...
livestrong.com/article/363926-what-are-the-side-effects-of-phenylalanine-aspartame/

*  post by tebyen

Today we have "Nutra-Sweet", which is widely used in a plethora of consumables, despite a demonstrated neurological reaction in some people. In February 1996, it was decided to also use the product name "Benevia". It is estimated that as many as 20,000,000 people cannot metabolize phenylalimine, and this inability is genetically inherited by children. The inability to metabolize phenylalinine can lead to mental retardation in children. This means a risk of retardation for millions of children. A multi-billion dollar enterprise, this substance is said to be "refined" from "natural" substances. Like other "refined" substances, it represents a health threat to the general public. No long term studies have been performed to evaluate the physiological effects of this substance, yet the public is lead to believe it is absolutely safe. Technically, the chemical is called aspartame, and it was once on a Pentagon list of biowarfare chemicals submitted to Congress. [1] Aspartame is in ...
abovetopsecret.com/forum/thread308817/pg2

*  Is aspartame dangerous? | CLASSIC | @ConspiracyStuff - The Rundown Live

Join Ben and Matt to learn the Stuff They Don't Want You To Know about everything from ancient history to UFOs, government secrets, and the future of civilization.. Here's where it gets crazy.. New videos every Monday, Wednesday and Friday.. Visit our Mothership: http://bit.ly/stdwytk-hsw-home ...
therundownlive.com/is-aspartame-dangerous-classic-conspiracystuff/

*  Graves Eye Disease and Hyperthyroid: Artificial Sweeteners (In Foods You Least Expect) and Grave's Disease!!

I've written before about eliminating foods containing aspartame and other artificial ingredients from my diet. For reference, go to the right hand column of this blog and head for the 'food' category on the list. I'm going to use this post to start listing the 'unusual suspects' as I will call them--foods that you would...
eyesee.typepad.com/hyperthyroid_graves_eye/2009/02/artificialsweetenersandgravesdisease-infoodsyoumaynotsuspect.html

*  Diet Doc's AppetiteZap Prescription Helps Patients Kick Diet Soda and Junk Food Habits

PORTLAND, ME--(Marketwired - April 26, 2017) - It's a well-known fact that diet soda isn't the healthiest beverage out there. Traditionally low in calories and high in artificial sweeteners, diet soda has become increasingly under fire for its role in a bevy of health conditions. Aspartame (also known as NutraSweet),...
marketwired.com/press-release/diet-docs-appetitezap-prescription-helps-patients-kick-diet-soda-junk-food-habits-2211981.htm

*  Newborn pku says thyroid problem help! - Weddingbee

I work with adults with developmental disabilities, and one of my clients has PKU. She is disabled because they didn't test for it at the time she was born, and therefore she was not on the diet. Just stay calm, prepare questions, and most importantly, know that your daughter will be just fine! My client has a little brother with it who has a PhD and is amazingly successful and totally normal. It's all about how strict you are with the diet. I'm not sure how it is for infants, but I do know about the diet for when she is older. There is a formula that everyone drinks that will help them to receive a lot of nutrients since their diet is so limited. Avoid aspartame, gluten, protein, dairy, and artificial sweeteners to help make sure her PHE levels don't get too high. The formula doesn't taste very good, so being creative and putting it in a blender with some ice and fresh fruit to make a smoothie is a great way to help make it taste a little bit better! There are a lot of companies who make ...
boards.weddingbee.com/topic/newborn-pku-says-thyroid-problem-help/

*  November, 2015 | Recipe4Wellness

We don't put GMO ingredients on our labels in the United States. Other countries do and won't take our foods because of our GMO ingredients. Here are 6 ways to avoid GMOs so we can take our health back:. Corn, Canola, Soy, Cottonseed: Avoid these ingredients unless they are organic or say non-GMO. Watch for soy lecithin, soy protein, food starch, textured vegetable protein, and mixed tocopherols (vitamin E).. Code number on Produce: Avoid those that begin with the number 8. The ones with 9 are organic. Stick with those.. Sugars: Sugar beets are GMO.. Artificial Sweeteners: Aspartame or Nutrasweet is made by using GM bacterial strains of E. Coli!. Additives: Some xanthan gum, citric acid, maltodextrin, lactic acid, dextrose, caramel color, baking powder, malt syrup, modified food starch, sorbitol, stearic acid.. Dairy Products: Any non-organic or those that do not contain a "No rBGH" label . It's created using GMO E. Coli just like Nutrasweet!. Also, avoid these candy bars because of GMO ...
recipe4wellness.com/2015/11/

*  Health Diaries: Why low-fat is not low-cal

ii. In 1951, another sweetener named aspartame was developed. Marketed under brand names like Sugar Free, Equal, Nutrasweet and Sweetex Gold, it is available in the form of a tablet or granules and is, today, the most popular and widely used low calorie sweetener in the world. It loses its sweetness when heated though, so it cannot be used for cooking or baking. It can be used to prepare a limited range of Indian sweets such as gajar ka halwa, rasmalai or rasgollas that can be sweetened after cooking. ...
yourhealthdiary.blogspot.com/2010/04/why-low-fat-is-not-low-cal.html

*  The Cardboard Diet: November 2006

The nasty side-effects of aspartame are well known, so when I'm looking for an occasional treat (let's face it, we all need a bit of comfort food from time to time), I tend to avoid anything containing it. Much of Boots' (the Chemists) range of diabetic sweets, chocolate and biscuits contain both sweeteners, but their dark chocolate mint discs and shortbread fingers, just use maltitol, and the chocolate discs are dairy-free to boot! So I've availed myself of a couple of packets to get me through that 'time of the month'. And they're really not bad. Diabetic chocolate is never going to be the same as normal chocolate (and I still crave a bar of Dairy Milk from time to time), but it's not far off and the shortbread fingers are a revelation: buttery and delicious, with no perceptible difference from 'normal' shortbread. Great ...
cardboard-diet.blogspot.com/2006_11_01_archive.html

*  Best waist reducing diet - Diet Blog

The majority could have pre-programmed workout routines, resistance settings, forwardreverse motion, twin motion handles and foot pedals and some can have an influence incline. Whether or not you wish to bulk up, best waist reducing diet extra curvaceous calves, enhance your chest, or get hold of best waist reducing diet completely different muscle creating intention, you"re about to get eleven tips to build muscle quick. Simply just make sure you start slowly and build points up. Plant based whole grain diet recipes also cuts calories by attaching itself to a number of the other proteins and fat that you simply eat and eliminates them as effectively. At the finish of that minute you ought to be "winded" and ready to slow down. Carbonated drinks leak phosphorus from the bones and the aspartame in sodas because it trigger reminiscence loss. Arthur Agatston. Principally, as long as they're going to discover their supply of meals, they pretty much dwell illness free. Bread constituted of ...
myrianjuarez.com/best-diet/best-waist-reducing-diet.html

AspartameSweetness: Sweetness is one of the five basic tastes and is universally regarded as a pleasurable experience, except perhaps in excess. Foods rich in simple carbohydrates such as sugar are those most commonly associated with sweetness, although there are other natural and artificial compounds that are sweet at much lower concentrations, allowing their use as non-caloric sugar substitutes.Dipeptide: A dipeptide is a sometimes ambiguous designation of two classes of organic compounds: Its molecules contain either two amino acids joined by a single peptide bond or one amino acid with two peptide bonds.Phenylalanine N-monooxygenase: Phenylalanine N-monooxygenase (, phenylalanine N-hydroxylase, CYP79A2) is an enzyme with system name L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reactionStevia: Stevia (, or )Both and are recorded by at least some US and UK dictionaries, but the former is more common in US English (listed first or exclusively) and the latter is more common in UK English. is a sweetener and sugar substitute extracted from the leaves of the plant species Stevia rebaudiana.Kikunae Ikeda: was a Japanese chemist and Tokyo Imperial University professor of Chemistry who, in 1908, uncovered the chemical basis of a taste he named umami. It is one of the five basic tastes along with sweet, bitter, sour and salty.Taste: Taste, gustatory perception, or gustationAdjectival form: [is the sensory impression of food] or other substances on the tongue and is one of the [[sense|five traditional senses.E350 (food additive): E350 is an EU recognised food additive. It comes in two forms,Sucrose gap: The sucrose gap technique is used to create a conduction block in nerve or muscle fibers. A high concentration of sucrose is applied to the extracellular space to increase resistance between two groups of cells, which prevents the correct opening and closing of sodium and potassium channels.Electrogustometry: Electrogustometry is the measurement of taste threshold by passing controlled anodal current through the tongue. When current passes through the tongue a unique and distinct metallic taste is perceived.Assugrin

(1/86) Interaction of nucleotides with Asp(351) and the conserved phosphorylation loop of sarcoplasmic reticulum Ca(2+)-ATPase.

The nucleotide binding properties of mutants with alterations to Asp(351) and four of the other residues in the conserved phosphorylation loop, (351)DKTGTLT(357), of sarcoplasmic reticulum Ca(2+)-ATPase were investigated using an assay based on the 2', 3'-O-(2,4,6-trinitrophenyl)-8-azidoadenosine triphosphate (TNP-8N(3)-ATP) photolabeling of Lys(492) and competition with ATP. In selected cases where the competition assay showed extremely high affinity, ATP binding was also measured by a direct filtration assay. At pH 8.5 in the absence of Ca(2+), mutations removing the negative charge of Asp(351) (D351N, D351A, and D351T) produced pumps that bound MgTNP-8N(3)-ATP and MgATP with affinities 20-156-fold higher than wild type (K(D) as low as 0.006 microM), whereas the affinity of mutant D351E was comparable with wild type. Mutations K352R, K352Q, T355A, and T357A lowered the affinity for MgATP and MgTNP-8N(3)-ATP 2-1000- and 1-6-fold, respectively, and mutation L356T completely prevented photolabeling of Lys(492). In the absence of Ca(2+), mutants D351N and D351A exhibited the highest nucleotide affinities in the presence of Mg(2+) and at alkaline pH (E1 state). The affinity of mutant D351A for MgATP was extraordinarily high in the presence of Ca(2+) (K(D) = 0.001 microM), suggesting a transition state like configuration at the active site under these conditions. The mutants with reduced ATP affinity, as well as mutants D351N and D351A, exhibited reduced or zero CrATP-induced Ca(2+) occlusion due to defective CrATP binding.  (+info)

(2/86) On the sweetness of N-(trifluoroacetyl)aspartame.

A panel of tasters has found that the N-trifluoroacetyl derivative of aspartame is five times less sweet than the parent compound, contrary to the tenet in the literature, but consistent with sweet receptor models which require this nitrogen to exist in protonated form.  (+info)

(3/86) Genetic taste responses to 6-n-propylthiouracil among adults: a screening tool for epidemiological studies.

Genetically mediated taste responsiveness to 6-n-propylthiouracil (PROP) has been linked to reduced acceptance of some bitter foods. In this community-based study male (n = 364) and female (n = 378) adults enrolled in a self-help dietary intervention trial were screened for PROP taster status. Respondents, aged 18--70 years, were mailed filter papers impregnated with PROP or with aspartame solutions. They received instructions to rate taste intensity and hedonic preference using nine point category scales. Women rated PROP as more bitter than did men. Both sweetness and bitterness ratings were lower for older adults. Taste responsiveness to PROP was unrelated to body mass index in women or men. Higher bitterness ratings for PROP were weakly associated with higher sweetness ratings for aspartame, but were unrelated to sweet taste preferences. Successful administration of PROP filter papers by mail suggests new avenues for the screening of taste phenotypes in epidemiological studies.  (+info)

(4/86) Whole nerve chorda tympani responses to sweeteners in C57BL/6ByJ and 129P3/J mice.

The C57BL/6ByJ (B6) strain of mice exhibits higher preferences than does the 129P3/J (129) strain for a variety of sweet tasting compounds. We measured gustatory afferent responses of the whole chorda tympani nerve in these two strains using a broad array of sweeteners and other taste stimuli. Neural responses were greater in B6 than in 129 mice to the sugars sucrose and maltose, the polyol D-sorbitol and the non-caloric sweeteners Na saccharin, acesulfame-K, SC-45647 and sucralose. Lower neural response thresholds were also observed in the B6 strain for most of these stimuli. The strains did not differ in their neural responses to amino acids that are thought to taste sweet to mice, with the exception of L-proline, which evoked larger responses in the B6 strain. Aspartame and thaumatin, which taste sweet to humans but are not strongly preferred by B6 or 129 mice, did not evoke neural responses that exceeded threshold in either strain. The strains generally did not differ in their neural responses to NaCl, quinine and HCl. Thus, variation between the B6 and 129 strains in the peripheral gustatory system may contribute to differences in their consumption of many sweeteners.  (+info)

(5/86) Application of the U and gamma' models in binary sweet taste mixtures.

The U and Gamma' models of sensory interactions, successfully applied in olfaction for several years, are tested here using data from published studies on sweetness. The models are subsequently tested on new data obtained in studies of binary mixtures of four sodium sulfamates. The U model allows for the estimation of a global interaction, whereas the Gamma' model allows for the distinction between that which is due to an intrinsic interaction in the mixture itself and that which may be due to the power function exponents in the mixture. The models give satisfactory predictions for observed phenomena of sweet taste suppression, synergism or pure additivity. Additionally, they appear to be more suitable than other models recently applied in taste, particularly the equiratio model. Application of the models to the sulfamate mixtures, reveals additivity for sodium cyclohexylsulfamate (cyclamate)/potassium cyclohexylsulfamate and sodium cyclohexylsulfamate/sodium exo-2-norbornylsulfamate, respectively; whereas for sodium cyclohexylsulfamate/sodium 3-bromophenylsulfamate, the models revealed a slight hypo addition which is simply due to the dissimilarity values of the power function exponents of the components.  (+info)

(6/86) The effect of various substances on the suppression of the bitterness of quinine-human gustatory sensation, binding, and taste sensor studies.

The purpose of this study was to quantify the degree of suppression of the perceived bitterness of quinine by various substances and to examine the mechanism of bitterness suppression. The following compounds were tested for their ability to suppress bitterness: sucrose, a natural sweetener; aspartame, a noncaloric sweetener; sodium chloride (NaCl) as the electrolyte; phosphatidic acid, a commercial bitterness suppression agent; and tannic acid, a component of green tea. These substances were examined in a gustatory sensation test in human volunteers, a binding study, and using an artificial taste sensor. Sucrose, aspartame, and NaCl were effective in suppressing bitterness, although at comparatively high concentrations. An almost 80% inhibition of bitterness (calculated as concentration %) of a 0.1 mM quinine hydrochloride solution required 800 mM of sucrose, 8 mM of aspartame, and 300 mM NaCl. Similar levels of bitterness inhibition by phosphatidic acid and tannic acid (81.7, 61.0%, respectively) were obtained at much lower concentrations (1.0 (w/v)% for phosphatidic acid and 0.05 (w/v)% for tannic acid). The mechanism of the bitterness-depressing effect of phosphatidic acid and tannic acid was investigated in terms of adsorption and masking at the receptor site. With phosphatidic acid, 36.1% of the bitterness-depressing effect was found to be due to adsorption, while 45.6% was due to suppression at the receptor site. In the case of 0.05 (w/v)% tannic acid, the total bitterness-masking effect was 61.0%. The contribution of the adsorption effect was about 27.5% while the residual masking effect at the receptor site was almost 33%. Further addition of tannic acid (0.15 (w/v)%), however, increased the bitterness score of quinine, which probably represents an effect of the astringency of tannic acid itself. Finally, an artificial taste sensor was used to evaluate or predict the bitterness-depressing effect. The sensor output profile was shown to reflect the depressant effect at the receptor site rather well. Therefore, the taste sensor is potentially useful for predicting the effectiveness of bitterness-depressant substances.  (+info)

(7/86) Formaldehyde-induced shrinkage of rat thymocytes.

To test the possibility that micromolar formaldehyde, a metabolite of methanol derived from aspartame, exerts cytotoxicity, its effect on rat thymocytes was examined under the in vitro condition using a flow cytometer. Incubation of thymocytes with formaldehyde at 100 micro M or more for 24 h significantly increased the populations of shrunken cells and cells with hypodiploid DNA. The peak blood concentration of methanol in human subjects administered abuse doses of aspartame has been reported to exceed 2 mg/dL (625 micro M). It would increase the population of thymocytes undergoing apoptosis if formaldehyde at 100 micro M or more appears in the blood after administration of aspartame.  (+info)

(8/86) Modified DNA aptamers against sweet agent aspartame.

We obtained a modified DNA aptamer against sweetener, aspartame, by in vitro selection method. The modified DNA was prepared from dATP, dGTP, dCTP and a modified dTTP bearing a terminal amino group at C-5 position in place of thymidine by PCR using a hyper thermophilic DNA polymerase, KOD Dash DNA polymerase. The synthetic 102-mer DNA with a 60-mer random region was used as an initial template for the PCR. The PCR-amplified modified DNA library was applied to an aspartame-agarose column, and then the bound modified DNA was eluted from the column for the affinity chromatography selection. Repeating the procedure, we selected the modified DNA aptamer against aspartame.  (+info)



sweetener


  • While aspartame, like other peptides, has a caloric value of 4 kilocalories per gram, the quantity of aspartame needed to produce a sweet taste is so small as to make its caloric contribution negligible, which makes it a popular sweetener for those trying to avoid calories from sugar. (edinformatics.com)
  • The U.S. patent on aspartame expired in 1992 , and the aspartame market is now hotly contested between the NutraSweet Company and other manufacturers, chiefly the Holland Sweetener Company . (edinformatics.com)
  • Blends of aspartame with Acesulfame potassium are purported to have a more sugar-like taste, and to be more potent than either sweetener used alone. (edinformatics.com)
  • In products that may require a longer shelf life, such as syrups for fountain beverages, aspartame is sometimes blended with a more stable sweetener, such as saccharine . (edinformatics.com)
  • I have seen first hand the effects on symptoms when individuals have abstained from ingesting the artificial sweetener, aspartame. (life-enthusiast.com)
  • BELLEVUE, WASH. - Ajinomoto Food Ingredients, L.L.C., Chicago, has chosen ChemPoint.com as its exclusive North American channel partner for aspartame, a low-calorie sweetener. (foodbusinessnews.net)
  • Although the FDA considers aspartame to be a "safe and suitable" sweetener, a recent Yale University study appears to directly challenge the claim that aspartame would reduce obesity. (activistpost.com)
  • Apparently, when if you want to get rid of ants, all you have to do is to provide them with a package or two of sweetener containing aspartame and the colony will quickly die. (laidbackgardener.blog)
  • According to the tip I heard, it is important use a sweetener containing a blend of aspartame and dextrose, as the ants will not touch aspartame when it is presented alone. (laidbackgardener.blog)
  • That's when the satirical website The Spoof ran an article called " FDA certifies Aspartame as Ant Poison ", an attempt to parody the many anti-sweetener sites that claim various sugar substitutes (aspartame, sucralose, saccharin, etc.) are toxic to humans. (laidbackgardener.blog)

sucralose


  • There are four main artificial sweeteners on the market today - saccharin, aspartame, sucralose, and stevia - each has their own positives and negatives you need to know about. (breakingmuscle.com)
  • The new recipe for Diet Pepsi and Diet Pepsi Wild Cherry replaces aspartame with a blend of sucralose and acesulfame potassium. (businesstimes.com.sg)

aspartic acid


  • The company particularly defended its use of aspartame -- composed of aspartic acid and phenylalanine -- claiming its safety was "supported by more than 200 studies over the last 40 years. (upi.com)
  • It's so sneaky, has so many names (aspartame, E951, aspartic acid) and relatives that it's almost impossible to avoid it, but I do my best! (experienceproject.com)

artificial


  • Two powerful dairy organizations, The International Dairy Foods Association (IDFA) and the National Milk Producers Federation (NMPF), are petitioning the Food and Drug Administration to allow aspartame and other artificial sweeteners to be added to milk and other dairy products without a label. (activistpost.com)
  • They claim that aspartame and other artificial sweeteners would promote healthy eating and is good for school children. (activistpost.com)
  • To submit a formal comment or send data to the FDA concerning adding aspartame and other artificial sweeteners to milk products CLICK HERE . (activistpost.com)
  • One of the most studied artificial sweeteners, aspartame has been accused of causing everything from weight gain to cancer. (health.com)

NutraSweet


  • In this merger, Searle's aspartame business became a separate Monsanto subsidiary, the NutraSweet Company. (edinformatics.com)
  • Aspartame is sold under various brand names including Equal and NutraSweet and has few calories. (blogspot.com)
  • C14h18n2o5, Aspartame Granular, Nutrasweet manufacturer / supplier in China, offering Aspartame Powder/Granular 22839-47-0, Dipropylene Glycol Methyl Ether Acetate (DPMA CAS No: 88917-22-0), Self Adhesive Paper and so on. (made-in-china.com)

Sweet Misery


  • I have intentionally been trying to avoid posting about aspartame, but Joe Mercola recently posted a reference to the relatively old Sweet Misery anti-aspartame documentary which I have already seen more times that I would like and responded to. (skeptoid.com)

phenylalanine


  • Products containing aspartame usually have a warning label that they contain phenylalanine , in compliance with U.S. FDA guidelines. (edinformatics.com)
  • Since aspartame contains phenylalanine, aspartame products must carry a warning label. (upmc.com)

Coca-Cola


  • Our use of high-quality, low- and no- calorie sweeteners, including aspartame, allows us to give people great-tasting options they can feel good about," Coca-Cola claimed in the ad. (upi.com)
  • Aspartame: Insane Rots your Brain Found in Pepsi and Coca Cola And Robinson's Barley Water To name but a few Aspartame: Insane Rots your Brain Put there by Cain Or his bloodline anyway Who run the world And don't like you too. (experienceproject.com)
  • Sales of Coca-Cola Co's Diet Coke, which also uses aspartame, dropped 6.6 per cent. (businesstimes.com.sg)
  • Coca-Cola has no plans to remove aspartame from the beverage. (businesstimes.com.sg)

Acesulfame


  • Acesulfame potassium was first approved for food in 1988 and is used in drinks such as Coke Zero, which also contains some aspartame. (businesstimes.com.sg)

calorie


  • According to this tip, aspartame was originally developed as an ant poison before it was discovered it could also be used as low-calorie sugar substitute for humans. (laidbackgardener.blog)

diabetics


  • Aspartame is one of the sugar substitutes used by diabetics . (edinformatics.com)
  • The FDA has found aspartame to be safe for the general public, diabetics, pregnant and nursing women, and for children. (upmc.com)

humans


  • Whatever you may believe when it comes to the effects of aspartame on humans (I have no intention of discussing that issue, which is in no way related to a blog about horticulture), ants are not poisoned by aspartame, nor does it repel them. (laidbackgardener.blog)

toxic


  • The beautiful aspect of this movie is that in a shot ninety minutes you will easily in the relaxed comfort of your home finally understand why aspartame is a toxic poison that needs to be avoided at all costs. (organicconsumers.org)
  • It is entirely fictitious", several sites took the article seriously and began to spread the information that aspartame is toxic to ants. (laidbackgardener.blog)

autism


  • Most recently it has been revealed that aspartame may be linked to autism in children. (experienceproject.com)

Searle


  • Aspartame was discovered in 1965 by James M. Schlatter, a chemist working for G.D. Searle & Company . (edinformatics.com)
  • Former corporate officials, who began working for the Food and Drug Administration (and vice versa), were very cavalier about issues uncovered at Searle surrounding their drug processing and issues involved with aspartame. (life-enthusiast.com)

Diet Pepsi


  • Diet Pepsi made without aspartame is scheduled to hit shelves across the US on Monday, marking the biggest change to the beverage in three decades. (businesstimes.com.sg)
  • Mr Kaufman declined to say whether the new Diet Pepsi might draw customers who are loyal to Diet Coke but are seeking a soda without aspartame. (businesstimes.com.sg)

consumption


  • Warning pregnant women should abstain from aspartame consumption. (experienceproject.com)
  • The panel used data from NHANES to determine the most current levels of aspartame consumption and found that at those levels, aspartame is safe for consumption, is not cancer-causing or capable of causing neurological damage. (blogspot.com)

market


  • The Aspartame Free Proteins Market report covers the present scenario and the growth prospects of the China Aspartame Free Proteins market for 2017-2022 The report covers the market landscape and its growth prospects over the coming years. (medgadget.com)
  • Aspartame Free Proteins Market report focuses on the major drivers and restraints for the key players. (medgadget.com)
  • The China Aspartame Free Proteins Industry report gives a comprehensive account of the China Aspartame Free Proteins market. (medgadget.com)

found


  • In the United States aspartame is often found in restaurants in blue packets. (edinformatics.com)
  • However, since being approved by the FDA in 1981, studies have found no convincing evidence and the FDA, the World Health Organization, and the American Dietetic Association say aspartame in moderation poses no threats. (health.com)

milk


poison


  • According to Wikipedia, aspartame is not a an ant poison and cannot be used to control ants. (laidbackgardener.blog)

people


  • I am a former investigator who worked with the US Food and Drug Administration: This is what I have to say about Aspartame and the people who brought it to our tables. (life-enthusiast.com)
  • I don't consume any aspartame because I don't like the taste, but this is good news for people who do use aspartame for various reasons. (blogspot.com)

times


  • At the concentrations used in soft drinks, aspartame is 180 times sweeter than sugar. (edinformatics.com)
  • It is between 7,000 and 13,000 times sweeter than table sugar depending on what it is added to, and is produced by the same company that makes aspartame. (health.com)

sugar


  • A few years ago, I received one of those mass emails written by a bereaved dog owner who claimed her dog suddenly went blind, fell over and died after eating sugar-free yogurt containing aspartame. (vetstreet.com)

drinks


  • Most soft-drinks have a pH between 3 and 5, where aspartame is reasonably stable. (edinformatics.com)
  • The concerns about aspartame come as US consumers are increasingly seeking natural and organic ingredients in their food and drinks. (businesstimes.com.sg)

safe


  • A new study which involved a review of more than 500 reports by an international panel from 10 universities and medical schools states that aspartame is safe. (blogspot.com)

problems


  • The problems with aspartame include not only the biochemical nature of this toxin but also it sheds light on the political nature of the players involved. (life-enthusiast.com)
  • A small amount of methanol may cause some gastrointestinal upset, but it's not likely that a mammal can eat enough aspartame to cause serious problems. (vetstreet.com)

tell


  • What I can tell you, regarding toxicology, histology and biochemistry, is that aspartame is neurotoxic. (life-enthusiast.com)
  • Consequently, I'm here to tell you that aspartame poisoning in dogs and cats is highly unlikely. (vetstreet.com)

particularly


  • Aspartame, while probably not particularly good for anyone, has very few serious side effects in dogs and cats that we know of. (vetstreet.com)

food


  • In an e-mail link that I subscribe to: "naturalnews.com", is an informative article about the food sources that are the most prevalent in containing aspartame.http://www.naturalnews.com/035322_aspartame_sources_infographic.htmlI know it's important to review labels before. (experienceproject.com)
  • Blogger Vani Hari, who calls herself the Food Babe, has deemed aspartame "one of the most dangerous substances allowed in our food supply. (businesstimes.com.sg)

cancer


  • In 1980 , the FDA convened a Public Board of Inquiry (PBOI) consisting of independent advisors charged with examining the purported relationship between aspartame and brain cancer. (edinformatics.com)
  • The PBOI concluded that aspartame did not cause brain damage, but it recommended against approving aspartame at that time, citing unanswered questions about cancer in laboratory rats. (edinformatics.com)

cause


  • I swear I try really hard to avoid talking about aspartame all the time but it seems to be a lost cause. (skeptoid.com)

brain damage


  • For example, last week I received this email from a confused dog owner: "I just read on the Internet that aspartame causes pets to go blind and get brain damage. (vetstreet.com)

major


  • Make no bones about it, aspartame is a major factor in many symptomologies due to its effects upon brain chemistry. (life-enthusiast.com)

result


  • After searching the Internet thoroughly (she claimed), the owner concluded that methanol poisoning as a result of aspartame ingestion was what killed her dog. (vetstreet.com)

breaks


  • Aspartame, being a peptide , breaks down into its constituent amino acids when heated in the presence of water and acids. (edinformatics.com)

data


  • In 1981 , FDA Commissioner Arthur Hull Hayes , newly appointed by President Ronald Reagan , approved aspartame for use in dry goods, citing data from a Japanese study that had not been available to the members of the PBOI. (edinformatics.com)

drug


  • Schlatter had synthesized aspartame in the course of producing an anti- ulcer drug candidate. (edinformatics.com)

taste


  • He discovered its sweet taste serendipitously when he licked his finger, which had accidentally become contaminated with aspartame. (edinformatics.com)
  • Some find the taste of aspartame very unpleasant. (edinformatics.com)