American Native Continental Ancestry Group
Asian Continental Ancestry Group
African Continental Ancestry Group
European Continental Ancestry Group
Oceanic Ancestry Group
Asian Americans
Asia
Genealogy and Heraldry
Polymorphism, Single Nucleotide
Genetics, Population
Ethnic Groups
Genome-Wide Association Study
Genotype
Asia, Southeastern
Haplotypes
Gene Frequency
African Americans
Genetic Predisposition to Disease
Indians, South American
Gene Pool
Far East
Genetic Loci
Trinidad and Tobago
Alleles
Hispanic Americans
Genetic polymorphism and interethnic variability of plasma paroxonase activity. (1/8027)
A method for determining plasma paroxonase activity using an auto-analyser is described. Frequency distributions for British and Indian subjects show bimodality. A study of 40 British families confirms the presence of a genetic polymorphism with regard to plasma paroxonase activity. Two phenotypes can be defined, controlled by two alleles at one autosomal locus. The frequency of the low activity phenotype is less in the Indian population than in the British population. Malay, Chinese, and African subjects fail to show obvious bimodality. (+info)Cephalometric abnormalities in non-obese and obese patients with obstructive sleep apnoea. (2/8027)
The aim of this work was to comprehensively evaluate the cephalometric features in Japanese patients with obstructive sleep apnoea (OSA) and to elucidate the relationship between cephalometric variables and severity of apnoea. Forty-eight cephalometric variables were measured in 37 healthy males and 114 male OSA patients, who were classed into 54 non-obese (body mass index (BMI) <27 kg x m(-2), apnoea-hypopnoea index (AHI)=25.3+/-16.1 events x h(-1)) and 60 obese (BMI > or = 27 kg x m(-2), AHI=45.6+/-28.0 events h(-1)) groups. Diagnostic polysomnography was carried out in all of the OSA patients and in 19 of the normal controls. The non-obese OSA patients showed several cephalometric defects compared with their BMI-matched normal controls: 1) decreased facial A-P distance at cranial base, maxilla and mandible levels and decreased bony pharynx width; 2) enlarged tongue and inferior shift of the tongue volume; 3) enlarged soft palate; 4) inferiorly positioned hyoid bone; and 5) decreased upper airway width at four different levels. More extensive and severe soft tissue abnormalities with a few defects in craniofacial bony structures were found in the obese OSA group. For the non-obese OSA group, the stepwise regression model on AHI was significant with two bony structure variables as determinants: anterior cranial base length (S-N) and mandibular length (Me-Go). Although the regression model retained only linear distance between anterior vertebra and hyoid bone (H-VL) as an explainable determinant for AHI in the obese OSA group, H-VL was significantly correlated with soft tissue measurements such as overall tongue area (Ton), inferior tongue area (Ton2) and pharyngeal airway length (PNS-V). In conclusion, Japanese obstructive sleep apnoea patients have a series of cephalometric abnormalities similar to those described in Caucasian patients, and that the aetiology of obstructive sleep apnoea in obese patients may be different from that in non-obese patients. In obese patients, upper airway soft tissue enlargement may play a more important role in the development of obstructive sleep apnoea, whereas in non-obese patients, bony structure discrepancies may be the dominant contributing factors for obstructive sleep apnoea. (+info)Laboratory assay reproducibility of serum estrogens in umbilical cord blood samples. (3/8027)
We evaluated the reproducibility of laboratory assays for umbilical cord blood estrogen levels and its implications on sample size estimation. Specifically, we examined correlation between duplicate measurements of the same blood samples and estimated the relative contribution of variability due to study subject and assay batch to the overall variation in measured hormone levels. Cord blood was collected from a total of 25 female babies (15 Caucasian and 10 Chinese-American) from full-term deliveries at two study sites between March and December 1997. Two serum aliquots per blood sample were assayed, either at the same time or 4 months apart, for estrone, total estradiol, weakly bound estradiol, and sex hormone-binding globulin (SHBG). Correlation coefficients (Pearson's r) between duplicate measurements were calculated. We also estimated the components of variance for each hormone or protein associated with variation among subjects and variation between assay batches. Pearson's correlation coefficients were >0.90 for all of the compounds except for total estradiol when all of the subjects were included. The intraclass correlation coefficient, defined as a proportion of the total variance due to between-subject variation, for estrone, total estradiol, weakly bound estradiol, and SHBG were 92, 80, 85, and 97%, respectively. The magnitude of measurement error found in this study would increase the sample size required for detecting a difference between two populations for total estradiol and SHBG by 25 and 3%, respectively. (+info)A case-control study of risk factors for Haemophilus influenzae type B disease in Navajo children. (4/8027)
To understand the potential risk factors and protective factors for invasive Haemophilus influenzae type b (Hib) disease, we conducted a case-control study among Navajo children less than two years of age resident on the Navajo Nation. We analyzed household interview data for 60 cases that occurred between August 1988 and February 1991, and for 116 controls matched by age, gender, and geographic location. The Hib vaccine recipients were excluded from the analyses. Conditional logistic regression models were fit to examine many variables relating to social and environmental conditions. Risk factors determined to be important were never breast fed (odds ratio [OR] = 3.55, 95% confidence interval [CI] = 1.52, 8.26), shared care with more than one child less than two years of age (OR = 2.32, 95% CI = 0.91, 5.96); wood heating (OR = 2.14, 95% CI = 0.91, 5.05); rodents in the home (OR = 8.18, 95% CI = 0.83, 80.7); and any livestock near the home (OR = 2.18, 95% CI = 0.94, 5.04). (+info)Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women. (5/8027)
Plasmin-alpha2-antiplasmin complex (PAP) marks plasmin generation and fibrinolytic balance. We recently observed that elevated levels of PAP predict acute myocardial infarction in the elderly, yet little is known about the correlates of PAP. We measured PAP in 800 elderly subjects who were free of clinical cardiovascular disease in 2 cohort studies: the Cardiovascular Health Study and the Honolulu Heart Program. Median PAP levels did not differ between the Cardiovascular Health Study (6.05+/-1.46 nmol/L) and the Honolulu Heart Program (6.11+/-1.44 nmol/L), and correlates of PAP were similar in both cohorts. In CHS, PAP levels increased with age (r=0. 30), procoagulant factors (eg, factor VIIc, r=0.15), thrombin activity (prothrombin fragment F1+2, r=0.29), and inflammation-sensitive proteins (eg, fibrinogen, r=0.44; factor VIIIc, r=0.37). PAP was associated with increased atherosclerosis as measured by the ankle-arm index (AAI) (P for trend, +info)Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS). (6/8027)
Hyperinsulinemia is associated with the development of coronary heart disease. However, the underlying mechanisms are still poorly understood. Hypercoagulability and impaired fibrinolysis are possible candidates linking hyperinsulinism with atherosclerotic disease, and it has been suggested that proinsulin rather than insulin is the crucial pathophysiological agent. The aim of this study was to investigate the relationship of insulin and its precursors to markers of coagulation and fibrinolysis in a large triethnic population. A strong and independent relationship between plasminogen activator inhibitor-1 (PAI-1) antigen and insulin and its precursors (proinsulin, 32-33 split proinsulin) was found consistently across varying states of glucose tolerance (PAI-1 versus fasting insulin [proinsulin], r=0.38 [r=0.34] in normal glucose tolerance; r=0.42 [r=0.43] in impaired glucose tolerance; and r=0.38 [r=0.26] in type 2 diabetes; all P<0.001). The relationship remained highly significant even after accounting for insulin sensitivity as measured by a frequently sampled intravenous glucose tolerance test. In a stepwise multiple regression model after adjusting for age, sex, ethnicity, and clinic, both insulin and its precursors were significantly associated with PAI-1 levels. The relationship between fibrinogen and insulin and its precursors was significant in the overall population (r=0.20 for insulin and proinsulin; each P<0.001) but showed a more inconsistent pattern in subgroup analysis and after adjustments for demographic and metabolic variables. Stepwise multiple regression analysis showed that proinsulin (split products) but not fasting insulin significantly contributed to fibrinogen levels after adjustment for age, sex, clinic, and ethnicity. Decreased insulin sensitivity was independently associated with higher PAI-1 and fibrinogen levels. In summary, we were able to demonstrate an independent relationship of 2 crucial factors of hemostasis, fibrinogen and PAI-1, to insulin and its precursors. These findings may have important clinical implications in the risk assessment and prevention of macrovascular disease, not only in patients with overt diabetes but also in nondiabetic subjects who are hyperinsulinemic. (+info)Low-density lipoprotein particle size is inversely related to plasminogen activator inhibitor-1 levels. The Insulin Resistance Atherosclerosis Study. (7/8027)
High levels of plasminogen activator inhibitor-1 (PAI-1) and preponderance of small dense low-density lipoproteins (LDL) have both been associated with atherosclerotic disease and with the insulin resistance syndrome (IRS). In vitro studies have shown a stimulatory effect of various lipoproteins on PAI-1 release from different cells, including endothelial cells and adipocytes. The authors sought to investigate the relation of PAI-1 to LDL particle size in a large tri-ethnic population (n=1549) across different states of glucose tolerance. LDL size was determined by gradient gel electrophoresis, and PAI-1 was measured by a 2-site immunoassay, sensitive to free PAI-1. PAI-1 was inversely related to LDL size in the overall population (r=-0.21, P<0.0001), independent of gender and ethnicity. However, the authors found a significant interaction with glucose tolerance status (P=0.035). In univariate analysis, the association between PAI-1 and LDL size was most pronounced in subjects with normal glucose tolerance (NGT, r=-0.22, P<0.0001) and weaker in impaired glucose tolerance (IGT, r=-0.12, P=0.03) and type-2 diabetes (r=-0.10, P=0.02). After adjustment for demographic variables and metabolic variables known to influence PAI-1 levels (triglyceride and insulin sensitivity), a significant inverse relation of LDL size to PAI-1 levels was only present in NGT (P=0. 023). In subjects with IGT or overt diabetes, who usually have elevated PAI-1 levels, additional factors other than LDL size seem to contribute more importantly to PAI-1 levels. The demonstrated inverse relation of LDL size and PAI-1 levels provides one possible explanation for the atherogeneity of small dense LDL particles. (+info)Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. (8/8027)
OBJECTIVE: To investigate the effect of ethnicity on clinical and serologic expression in patients with systemic sclerosis (SSc) and anti-DNA topoisomerase I (anti-topo I) antibody. METHODS: Clinical and serologic features, as well as HLA class II allele frequencies, were compared among 47 North American white, 15 North American black, 43 Japanese, and 12 Choctaw Native American SSc patients with anti-topo I antibody. RESULTS: The frequency of progressive pulmonary interstitial fibrosis was lower, and cumulative survival rates were better in white compared with black and Japanese patients. Sera of white and black patients frequently recognized the portion adjacent to the carboxyl terminus of topo I, sera of Japanese patients preferentially recognized the portion adjacent to the amino terminus of topo I, and sera of Choctaw patients recognized both portions of topo I. Anti-RNA polymerase II and anti-SSA/Ro antibodies were present together with anti-topo I antibody more frequently in sera of Japanese patients than in sera of white patients. The HLA-DRB1 alleles associated with anti-topo I antibody differed; i.e., DRB1*1101-*1104 in whites and blacks, DRB1*1502 in Japanese, and DRB1*1602 in Choctaws. Multivariate analysis showed that ethnic background was an independent determinant affecting development of severe lung disease as well as survival. CONCLUSION: Clinical and serologic features in SSc patients were strongly influenced by ethnic background. The variability of disease expression in the 4 ethnic groups suggests that multiple factors linked to ethnicity, including genetic and environmental factors, modulate clinical manifestations, disease course, and autoantibody status in SSc. (+info)The term "American Native Continental Ancestry Group" is not a standard medical term, but it generally refers to individuals who have ancestral origins in the indigenous populations of North, Central, or South America. This group includes people who identify as American Indian, Alaska Native, Native Hawaiian, and other Pacific Islander.
It's important to note that this term is often used in genetic research to categorize participants based on their self-reported ancestry or genetic markers associated with certain populations. However, the use of such categories can be controversial because they oversimplify the complex and diverse histories of indigenous peoples and may perpetuate harmful stereotypes or misunderstandings.
Therefore, it is generally recommended to use more specific and culturally sensitive terms when referring to individuals' ancestry or cultural backgrounds.
The term "Asian Continental Ancestry Group" is a medical/ethnic classification used to describe a person's genetic background and ancestry. According to this categorization, individuals with origins in the Asian continent are grouped together. This includes populations from regions such as East Asia (e.g., China, Japan, Korea), South Asia (e.g., India, Pakistan, Bangladesh), Southeast Asia (e.g., Philippines, Indonesia, Thailand), and Central Asia (e.g., Kazakhstan, Uzbekistan, Tajikistan). It is important to note that this broad categorization may not fully capture the genetic diversity within these regions or accurately reflect an individual's specific ancestral origins.
The term "African Continental Ancestry Group" is a racial category used in the field of genetics and population health to describe individuals who have ancestral origins in the African continent. This group includes people from diverse ethnic backgrounds, cultures, and languages across the African continent. It's important to note that this term is used for genetic and epidemiological research purposes and should not be used to make assumptions about an individual's personal identity, culture, or experiences.
It's also worth noting that there is significant genetic diversity within Africa, and using a single category to describe all individuals with African ancestry can oversimplify this diversity. Therefore, it's more accurate and informative to specify the particular population or region of African ancestry when discussing genetic research or health outcomes.
The term "European Continental Ancestry Group" is a medical/ethnic classification that refers to individuals who trace their genetic ancestry to the continent of Europe. This group includes people from various ethnic backgrounds and nationalities, such as Northern, Southern, Eastern, and Western European descent. It is often used in research and medical settings for population studies or to identify genetic patterns and predispositions to certain diseases that may be more common in specific ancestral groups. However, it's important to note that this classification can oversimplify the complex genetic diversity within and between populations, and should be used with caution.
I'm sorry for any confusion, but "Oceanic Ancestry Group" is not a standard medical term or classification. It seems to be a general term that refers to people who have ancestral origins in the Oceanic region, which includes countries like Australia, New Zealand, and various islands in the Pacific Ocean.
In genetic or genealogical contexts, it might refer to a group of populations sharing certain genetic characteristics due to their geographical and historical connections. However, it's important to note that such classifications can be oversimplified and may not accurately reflect the complex genetic histories and cultural identities of individuals.
If you're looking for a medical term related to ancestry or genetics, you might be thinking of "racial" or "ethnic" categories, which are sometimes used in medical research or clinical settings to describe patterns of disease risk or treatment response. However, these categories are also flawed and can oversimplify the genetic and cultural diversity within and between populations. It's generally more useful and accurate to consider each individual's unique genetic and environmental factors when considering their health and medical needs.
According to the US Department of Health and Human Services, Asian Americans are defined as "a person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent including, for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam."
It's important to note that this definition is used primarily in a US context and may not be applicable or relevant in other parts of the world. Additionally, it's worth noting that the term "Asian American" encompasses a vast array of diverse cultures, languages, histories, and experiences, and should not be essentialized or oversimplified.
I apologize for any confusion, but "Asia" is not a medical term. It is the largest continent in the world, comprising about 30% of the Earth's total land area and containing around 60% of the world's current human population. It is divided into several regions, including Northern Asia (Siberia), Eastern Asia (China, Japan, Korea, Mongolia, Taiwan), Southern Asia (India, Pakistan, Bangladesh, Sri Lanka, Maldives), Southeastern Asia (Vietnam, Thailand, Indonesia, Philippines, Malaysia, Singapore, Myanmar, Cambodia, Laos, Brunei), and Western Asia (Middle East).
If you have any questions related to medical terminology or health-related topics, I'd be happy to help.
I'm sorry for any confusion, but it seems there might be a misunderstanding in your question. Genealogy and heraldry are two distinct subjects, each with its own definition. I will provide you with their separate definitions:
1. Genealogy - This is the study of family history, lineages, and descent. It involves researching ancestral origins, relationships, and historical records to construct a family tree or pedigree. Genealogists use various resources like birth, marriage, and death certificates; census records; church records; and DNA testing to trace the connections between individuals and families over generations.
2. Heraldry - This is the study of armorial bearings, also known as coats of arms. Heraldry involves the design, description, and use of these symbols, which were historically used by nobility, knights, and other privileged classes to identify themselves in battle, on seals, and in civic life. The heraldic elements often include shields, helmets, crests, mottoes, and other insignia that convey information about the bearer's ancestry, rank, occupation, or achievements.
While genealogy and heraldry can sometimes intersect (e.g., when studying the historical records of noble families with coats of arms), they are not inherently related as subjects within the medical field.
Single Nucleotide Polymorphism (SNP) is a type of genetic variation that occurs when a single nucleotide (A, T, C, or G) in the DNA sequence is altered. This alteration must occur in at least 1% of the population to be considered a SNP. These variations can help explain why some people are more susceptible to certain diseases than others and can also influence how an individual responds to certain medications. SNPs can serve as biological markers, helping scientists locate genes that are associated with disease. They can also provide information about an individual's ancestry and ethnic background.
Population Genetics is a subfield of genetics that deals with the genetic composition of populations and how this composition changes over time. It involves the study of the frequency and distribution of genes and genetic variations in populations, as well as the evolutionary forces that contribute to these patterns, such as mutation, gene flow, genetic drift, and natural selection.
Population genetics can provide insights into a wide range of topics, including the history and relationships between populations, the genetic basis of diseases and other traits, and the potential impacts of environmental changes on genetic diversity. This field is important for understanding evolutionary processes at the population level and has applications in areas such as conservation biology, medical genetics, and forensic science.
An ethnic group is a category of people who identify with each other based on shared ancestry, language, culture, history, and/or physical characteristics. The concept of an ethnic group is often used in the social sciences to describe a population that shares a common identity and a sense of belonging to a larger community.
Ethnic groups can be distinguished from racial groups, which are categories of people who are defined by their physical characteristics, such as skin color, hair texture, and facial features. While race is a social construct based on physical differences, ethnicity is a cultural construct based on shared traditions, beliefs, and practices.
It's important to note that the concept of ethnic groups can be complex and fluid, as individuals may identify with multiple ethnic groups or switch their identification over time. Additionally, the boundaries between different ethnic groups can be blurred and contested, and the ways in which people define and categorize themselves and others can vary across cultures and historical periods.
A Genome-Wide Association Study (GWAS) is an analytical approach used in genetic research to identify associations between genetic variants, typically Single Nucleotide Polymorphisms (SNPs), and specific traits or diseases across the entire genome. This method involves scanning the genomes of many individuals, usually thousands, to find genetic markers that occur more frequently in people with a particular disease or trait than in those without it.
The goal of a GWAS is to identify genetic loci (positions on chromosomes) associated with a trait or disease, which can help researchers understand the underlying genetic architecture and biological mechanisms contributing to the condition. It's important to note that while GWAS can identify associations between genetic variants and traits/diseases, these studies do not necessarily prove causation. Further functional validation studies are often required to confirm the role of identified genetic variants in the development or progression of a trait or disease.
Genotype, in genetics, refers to the complete heritable genetic makeup of an individual organism, including all of its genes. It is the set of instructions contained in an organism's DNA for the development and function of that organism. The genotype is the basis for an individual's inherited traits, and it can be contrasted with an individual's phenotype, which refers to the observable physical or biochemical characteristics of an organism that result from the expression of its genes in combination with environmental influences.
It is important to note that an individual's genotype is not necessarily identical to their genetic sequence. Some genes have multiple forms called alleles, and an individual may inherit different alleles for a given gene from each parent. The combination of alleles that an individual inherits for a particular gene is known as their genotype for that gene.
Understanding an individual's genotype can provide important information about their susceptibility to certain diseases, their response to drugs and other treatments, and their risk of passing on inherited genetic disorders to their offspring.
Southeast Asia is a geographical region that consists of the countries that are located at the southeastern part of the Asian continent. The definition of which countries comprise Southeast Asia may vary, but it generally includes the following 11 countries:
* Brunei
* Cambodia
* East Timor (Timor-Leste)
* Indonesia
* Laos
* Malaysia
* Myanmar (Burma)
* Philippines
* Singapore
* Thailand
* Vietnam
Southeast Asia is known for its rich cultural diversity, with influences from Hinduism, Buddhism, Islam, and Christianity. The region is also home to a diverse range of ecosystems, including rainforests, coral reefs, and mountain ranges. In recent years, Southeast Asia has experienced significant economic growth and development, but the region still faces challenges related to poverty, political instability, and environmental degradation.
A haplotype is a group of genes or DNA sequences that are inherited together from a single parent. It refers to a combination of alleles (variant forms of a gene) that are located on the same chromosome and are usually transmitted as a unit. Haplotypes can be useful in tracing genetic ancestry, understanding the genetic basis of diseases, and developing personalized medical treatments.
In population genetics, haplotypes are often used to study patterns of genetic variation within and between populations. By comparing haplotype frequencies across populations, researchers can infer historical events such as migrations, population expansions, and bottlenecks. Additionally, haplotypes can provide information about the evolutionary history of genes and genomic regions.
In clinical genetics, haplotypes can be used to identify genetic risk factors for diseases or to predict an individual's response to certain medications. For example, specific haplotypes in the HLA gene region have been associated with increased susceptibility to certain autoimmune diseases, while other haplotypes in the CYP450 gene family can affect how individuals metabolize drugs.
Overall, haplotypes provide a powerful tool for understanding the genetic basis of complex traits and diseases, as well as for developing personalized medical treatments based on an individual's genetic makeup.
Gene frequency, also known as allele frequency, is a measure in population genetics that reflects the proportion of a particular gene or allele (variant of a gene) in a given population. It is calculated as the number of copies of a specific allele divided by the total number of all alleles at that genetic locus in the population.
For example, if we consider a gene with two possible alleles, A and a, the gene frequency of allele A (denoted as p) can be calculated as follows:
p = (number of copies of allele A) / (total number of all alleles at that locus)
Similarly, the gene frequency of allele a (denoted as q) would be:
q = (number of copies of allele a) / (total number of all alleles at that locus)
Since there are only two possible alleles for this gene in this example, p + q = 1. These frequencies can help researchers understand genetic diversity and evolutionary processes within populations.
African Americans are defined as individuals who have ancestry from any of the black racial groups of Africa. This term is often used to describe people living in the United States who have total or partial descent from enslaved African peoples. The term does not refer to a single ethnicity but is a broad term that includes various ethnic groups with diverse cultures, languages, and traditions. It's important to note that some individuals may prefer to identify as Black or of African descent rather than African American, depending on their personal identity and background.
Genetic predisposition to disease refers to an increased susceptibility or vulnerability to develop a particular illness or condition due to inheriting specific genetic variations or mutations from one's parents. These genetic factors can make it more likely for an individual to develop a certain disease, but it does not guarantee that the person will definitely get the disease. Environmental factors, lifestyle choices, and interactions between genes also play crucial roles in determining if a genetically predisposed person will actually develop the disease. It is essential to understand that having a genetic predisposition only implies a higher risk, not an inevitable outcome.
Genetic variation refers to the differences in DNA sequences among individuals and populations. These variations can result from mutations, genetic recombination, or gene flow between populations. Genetic variation is essential for evolution by providing the raw material upon which natural selection acts. It can occur within a single gene, between different genes, or at larger scales, such as differences in the number of chromosomes or entire sets of chromosomes. The study of genetic variation is crucial in understanding the genetic basis of diseases and traits, as well as the evolutionary history and relationships among species.
I believe you are asking for a description or explanation of the indigenous peoples of South America, rather than a "medical definition." A medical definition would typically apply to a condition or disease. Here is some information about the indigenous peoples of South America:
The indigenous peoples of South America are the original inhabitants of the continent and its islands, who lived there before the European colonization. They include a wide variety of ethnic groups, languages, and cultures, with distinct histories and traditions. Many indigenous communities in South America have faced significant challenges, including displacement from their lands, marginalization, and discrimination.
According to estimates by the United Nations, there are approximately 45 million indigenous people in Latin America, of which about 30 million live in South America. They represent around 7% of the total population of South America. Indigenous peoples in South America can be found in all countries, with the largest populations in Bolivia (62%), Guatemala (41%), and Peru (25%).
Indigenous peoples in South America have a rich cultural heritage, including unique languages, arts, and spiritual practices. Many of these cultures are under threat due to globalization, urbanization, and the loss of traditional lands and resources. In recent years, there has been increased recognition of the rights of indigenous peoples in international law, including the right to self-determination, cultural heritage, and free, prior, and informed consent for projects that affect their territories. However, significant challenges remain, and many indigenous communities continue to face violence, discrimination, and poverty.
A gene pool refers to the total sum of genes contained within a population of interbreeding individuals of a species. It includes all the variations of genes, or alleles, that exist in that population. The concept of a gene pool is important in understanding genetic diversity and how traits are passed down from one generation to the next.
The size and diversity of a gene pool can have significant implications for the long-term survival and adaptability of a species. A larger and more diverse gene pool can provide a species with greater resistance to diseases, environmental changes, and other threats, as there is a wider variety of traits and genetic combinations available. On the other hand, a smaller or less diverse gene pool may make a species more susceptible to genetic disorders, reduced fitness, and extinction.
Geneticists and population biologists often study gene pools to understand the evolutionary history and dynamics of populations, as well as to inform conservation efforts for endangered species.
Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.
The term "Far East" is a geographical term that has been used historically to describe the easternmost part of Asia, including countries such as China, Japan, Korea, and Southeast Asian nations. However, it's important to note that the use of this term can be seen as outdated and culturally insensitive, as it originated during a time when Western powers viewed these regions as distant and exotic.
In medical contexts, "Far East" may be used to describe medical conditions or treatments specific to populations in this region. However, it is generally more appropriate to use the specific names of countries or regions when discussing medical issues related to these areas.
A genetic locus (plural: loci) is a specific location on a chromosome where a particular gene or DNA sequence is found. It is the precise position where a specific genetic element, such as a gene or marker, is located on a chromsomere. This location is defined in terms of its relationship to other genetic markers and features on the same chromosome. Genetic loci can be used in linkage and association studies to identify the inheritance patterns and potential relationships between genes and various traits or diseases.
I'm sorry for any confusion, but "Trinidad and Tobago" is not a medical term or concept. It is the name of a country located in the southern Caribbean Sea, off the northeastern coast of Venezuela. The country is an archipelago, consisting of two main islands, Trinidad and Tobago, and numerous smaller islands.
If you have any questions related to medical terminology or health-related topics, I'd be happy to help!
An allele is a variant form of a gene that is located at a specific position on a specific chromosome. Alleles are alternative forms of the same gene that arise by mutation and are found at the same locus or position on homologous chromosomes.
Each person typically inherits two copies of each gene, one from each parent. If the two alleles are identical, a person is said to be homozygous for that trait. If the alleles are different, the person is heterozygous.
For example, the ABO blood group system has three alleles, A, B, and O, which determine a person's blood type. If a person inherits two A alleles, they will have type A blood; if they inherit one A and one B allele, they will have type AB blood; if they inherit two B alleles, they will have type B blood; and if they inherit two O alleles, they will have type O blood.
Alleles can also influence traits such as eye color, hair color, height, and other physical characteristics. Some alleles are dominant, meaning that only one copy of the allele is needed to express the trait, while others are recessive, meaning that two copies of the allele are needed to express the trait.
Hispanic Americans, also known as Latino Americans, are individuals in the United States who are of Spanish-speaking origin or whose ancestors came from Spain, Mexico, Cuba, the Caribbean, Central and South America. This group includes various cultures, races, and nationalities. It is important to note that "Hispanic" refers to a cultural and linguistic affiliation rather than a racial category. Therefore, Hispanic Americans can be of any race, including White, Black, Asian, Native American, or mixed races.
Linkage disequilibrium (LD) is a term used in genetics that refers to the non-random association of alleles at different loci (genetic locations) on a chromosome. This means that certain combinations of genetic variants, or alleles, at different loci occur more frequently together in a population than would be expected by chance.
Linkage disequilibrium can arise due to various factors such as genetic drift, selection, mutation, and population structure. It is often used in the context of genetic mapping studies to identify regions of the genome that are associated with particular traits or diseases. High levels of LD in a region of the genome suggest that the loci within that region are in linkage, meaning they tend to be inherited together.
The degree of LD between two loci can be measured using various statistical methods, such as D' and r-squared. These measures provide information about the strength and direction of the association between alleles at different loci, which can help researchers identify causal genetic variants underlying complex traits or diseases.
Universal Decimal Classification
List of MeSH codes (M01)
Human genetic clustering
Asian (South Africa)
Alameda County, California
Southeast Asia
Race and ethnicity in censuses
Jōmon people
Jamestown, New York
Y Chromosome Haplotype Reference Database
Human genetic variation
Asian Americans
Ethnic origins of people in Canada
Chinese Americans
Multiracial Americans
Western Hunter-Gatherer
List of transcontinental countries
Multiregional origin of modern humans
Lynn, Massachusetts
New York (state)
Lower Pottsgrove Township, Pennsylvania
Early human migrations
Cumans
Antonio Arnaiz-Villena
Demographics of Bermuda
Japanese Americans
Genetic history of the Indigenous peoples of the Americas
Genetic history of Europe
Haplogroup R (Y-DNA)
Brampton
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DeCS - 2004 Edition
DeCS 2004 - Deleted terms
DeCS - 2004 Edition
Updates for the 2022 edition - DeCS
DeCS - 2004 Edition
DeCS 2004 - Deleted terms
DeCS 2004 - Deleted terms
DeCS 2004 - Deleted terms
DeCS - 2004 Edition
DeCS 2004 - Deleted terms
DeCS - 2004 Edition
DeCS 2004 - Deleted terms
COMMON AUXILIARY NUMBERS. Universal Decimal Classification
Genome-Wide1
- Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. (ox.ac.uk)
Ethnic Groups6
- Compared with whites, other racial and ethnic groups were on average younger and had a higher median score on the National Institutes of Health Stroke Scale. (elsevierpure.com)
- To evaluate the possibility that such differences are accompanied by differences in brain structure, we conducted a large comparative study on cognitively matched young and old adults from two cultural/ethnic groups - Chinese Singaporeans and non-Asian Americans - that involved a total of 140 persons. (illinois.edu)
- it cannot be assumed that treatments shown to work for Caucasians will be efficacious for those from minority ethnic groups. (ox.ac.uk)
- OBJECTIVE: HbA(1c) levels are higher in most ethnic groups compared with white Europeans (WEs) independent of glycemic control. (ox.ac.uk)
- At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. (ox.ac.uk)
- Subjects identified themselves as belonging to one of four major racial/ethnic groups (white, African American, East Asian, and Hispanic) and were recruited from 15 different geographic locales within the United States and Taiwan. (blogspot.com)
Populations13
- The population frequency of the indel (rs66698963) is remarkably different among human populations with the insertion being far more frequent in South Asians, Africans and some East Asian populations, and far less common in European and other East Asian populations. (fatsoflife.com)
- We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. (ox.ac.uk)
- In order to determine a new subject's genetic ancestry, Parabon Snapshot analyzes tens of thousands of SNPs from a DNA sample to determine a person's percent membership in each of these global populations. (parabon-nanolabs.com)
- Most other forensic ancestry systems use only a small number of SNPs and thus are limited to very coarse populations and cannot detect admixture between populations. (parabon-nanolabs.com)
- Parabon's scientists have collected data from many published scientific articles, totalling more than 9,000 individuals with clearly defined ancestry from more than 150 populations around the world, as shown in the map below. (parabon-nanolabs.com)
- Academic research using hundreds of thousands of SNPs from across the genome has shown that human groups generally divide into seven continental populations, which have been established over the past 50,000 years during the migration out of Africa. (parabon-nanolabs.com)
- The 150 populations collected as the ancestry background can thus be divided into these seven continental groups according to their origin. (parabon-nanolabs.com)
- Snapshot takes a similar approach to identifying within-continental (regional) ancestry, although the local populations were identified through empirical analysis performed by our bioinformatics team. (parabon-nanolabs.com)
- In an ancestry analysis, Snapshot will determine an individual's precise genetic origins, as well as whether there is any evidence of admixture (contribution from multiple populations). (parabon-nanolabs.com)
- Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. (ox.ac.uk)
- Interethnic analyses of blood pressure loci in populations of East Asian and European descent. (ox.ac.uk)
- TMB-high was significantly associated with improved outcomes only in European ancestries and merits validation in non-European ancestry populations. (bvsalud.org)
- Because of extensive admixture among these various groups, the Brazilian population shows great variability in terms of Populations on different continents vary considerably in their skin pigmentation, phenotypic features, and genomic structure [2]. (cdc.gov)
Genetic ancestry7
- From ∼ 1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. (nature.com)
- Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)
- The EuroDNA(TM) 2.0 test is by far the most advanced genetic ancestry test yet to be offered to the public. (thegeneticgenealogist.com)
- Using two clinical cohorts, we investigated the interplay between genetic ancestry, TMB, and tumor-only versus tumor-normal paired sequencing in solid tumors. (bvsalud.org)
- We developed a framework for inference of germline variants from tumor panel sequencing, including imputation, quality control, inference of genetic ancestry, germline polygenic risk scores, and HLA alleles. (biomedcentral.com)
- We showcase the feasibility and utility of our framework by analyzing 25,889 tumors and identifying the relationships between genetic ancestry, polygenic risk, and tumor characteristics that could not be studied with conventional on-target tumor data. (biomedcentral.com)
- Worldwide, its incidence has increased progressively over the last a result of genetic ancestry. (cdc.gov)
Whites1
- Whites had higher 30-day unadjusted mortality than other groups (white versus black versus Hispanic versus Asian=15.0% versus 9.9% versus 11.9% versus 11.1%, respectively). (elsevierpure.com)
Ethnicity6
- This lack of association was not influenced by adjustment for sex, diastolic blood pressure, history of coronary disease, or ethnicity (Asian or non-Asian). (ox.ac.uk)
- Independent effect of ethnicity on glycemia in South Asians and white Europeans. (ox.ac.uk)
- We analyzed the independent effect of ethnicity on HbA(1c) and fasting and 2-h plasma glucose (FPG and 2 hrPG, respectively) between these groups. (ox.ac.uk)
- On the other hand, we detected only modest genetic differentiation between different current geographic locales within each race/ethnicity group. (blogspot.com)
- Thus, ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity-as opposed to current residence-is the major determinant of genetic structure in the U.S. population. (blogspot.com)
- In June 2002, ADC joined the American-Civil Liberties Union (ACLU) in filing lawsuits against American Airlines, United Airlines, and Continental Airlines alleging that the airlines engaged in the unlawful removals of Arab, Arab-American, Muslim, or South Asian passengers based on their perceived religion, ethnicity, or national origin. (adc.org)
Population Groups2
- The old descriptor ANIMALS will be changed to ANIMAL POPULATION GROUPS. (bvsalud.org)
- The NHANES II sample was selected so that certain population groups thought to be at high risk of malnutrition (persons with low incomes, preschool children and the elderly) were oversampled. (cdc.gov)
Loci2
Outcomes3
- Heart failure among South Asians: a narrative review of risk, nature, outcomes and management. (ox.ac.uk)
- These papers also implied that outcomes for South Asians with HF were similar or even better than for Caucasians. (ox.ac.uk)
- Our data suggest that survival of Korean-American gastric cancer patients are comparable with outcomes from East Asian hospitals and may be independent of surgical technique. (houstonmethodist.org)
Americans2
- 3060 non-Hispanic Asian Americans, 1.5%) from 926 US centers participating in the Get With The Guidelines-Stroke program from April 2003 through December 2008. (elsevierpure.com)
- This effect was consistent across a variety of targeted outgroups (Mainland Chinese, Arabs, Russians, Blacks, Asian Americans, and homosexuals), regardless of whether multicultural experience was measured or manipulated, and across samples (Hong Kongers, Jewish Israelis, and U.S.-born Americans). (iucc.ac.il)
Gastric cancer1
- Intriguingly, we found differences in the antiproliferative response between gastric cancer cells tested derived from Brazilian patients as compared to those from Asian patients, the latter being largely resistant to BET inhibition. (ox.ac.uk)
Informative Markers2
- DNAPrint(R)'s EuroDNA(TM) 2.0 clarifies European sub-ancestry by using 1,349 European Ancestry Informative Markers (AIMs). (thegeneticgenealogist.com)
- Model-based clustering and ancestry informative markers analyses suggested that this is due to taurine introgression. (biomedcentral.com)
Polymorphism2
- After attributing a regional and/or continental ancestry to each individual using genome-wide polymorphism data, we are able to capture the effect of different environmental exposures on gene expression and health-related traits, while simultaneously controlling for genetic relatedness and migration. (nature.com)
- The polymorphism was present as an insertion in cells derived from a group of Japanese individuals, but was completely absent (a deletion) in others, albeit with a lower frequency (hence called the minor allele). (fatsoflife.com)
Hispanic2
- After risk adjustment, Asian American patients with AIS had lower 30-day and 1-year mortality than white, black, and Hispanic patients. (elsevierpure.com)
- Results: Among the 70,221 included patients, 91.3% were white, 3.8% were black, 3.4% were Hispanic, and 1.5% were of Asian/Native American/Pacific Islander race. (elsevierpure.com)
Caucasians2
- The relationship between treatment response and genotype was assessed separately for Caucasians and Asians. (york.ac.uk)
- Therefore, a literature review relating to the nature, outcome and treatment of HF in South Asian patients compared to Caucasians was conducted. (ox.ac.uk)
Germline1
- TMB estimates from tumor-only panels substantially overclassified individuals into the clinically important TMB-high group due to germline contamination, and this bias was particularly pronounced in patients with Asian/African ancestry. (bvsalud.org)
Native American1
- Latino ancestry is a mixture of European and Native American ancestry, so these groups are shown as well. (parabon-nanolabs.com)
Traits3
- Ethnic ancestry is one of the most informative traits that can be predicted from DNA. (parabon-nanolabs.com)
- Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. (ox.ac.uk)
- We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related traits. (ox.ac.uk)
Tumor1
- Ancestry-aware tumor-only TMB calibration and ancestry-diverse biomarker studies are critical to ensure that existing disparities are not exacerbated in precision medicine. (bvsalud.org)
Evaluate1
- Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
European7
- Where EuroDNA 1.0 used just 320 SNPs to delineate people of European ancestry into four groups â€" Northern European, Southeastern European, Middle Eastern, and South Asian â€" EuroDNA 2.0 uses 1,349 SNPs. (thegeneticgenealogist.com)
- 2007 paper, looking for the SNPs that provided most of the European Ancestry Information. (thegeneticgenealogist.com)
- Global ancestry map showing mostly East Asian and Native/South American ancestry, with some European ancestry as well. (parabon-nanolabs.com)
- For example, the admixed East Asian and Latino example from the global map above was determined to have specifically Japanese, Central American, and Southwest European ancestry, as shown in the map below. (parabon-nanolabs.com)
- Regional ancestry map showing mostly Japanese, Southwest European, and Central American ancestry. (parabon-nanolabs.com)
- Each piece of continental ancestry is partitioned according to its regional ancestry (e.g., if an individual is 50% European and 50% East Asian, the precise origin of each of those pieces will be determined). (parabon-nanolabs.com)
- Conclusions: Our results indicate that European ancestry is a risk factor for cutaneous melanoma. (cdc.gov)
Descent1
- Individuals of South Asian descent have a high prevalence of comorbidities that are risk factors for the development of heart failure (HF), including diabetes mellitus and metabolic syndrome. (ox.ac.uk)
Racial1
- After risk-adjustment, there was no difference in the rates of in-hospital mortality, myocardial infarction, stroke, major bleeding, vascular complications, or new pacemaker requirements among the 4 racial groups. (elsevierpure.com)
Differences3
- However, group differences were evident when high-performing old were compared. (illinois.edu)
- It was anticipated that collating existing studies in this manner would be useful for guiding professionals in managing HF within this ethnic group, given that to achieve optimal care, regimens need to take into account cultural differences that may impact on adherence. (ox.ac.uk)
- These findings offer the first insights into ancestry-specific differences in the prostate cancer AR cistrome. (bvsalud.org)
Individuals3
- Drawing from this founding population of individuals with largely French ancestry, we selected 1007 individuals to determine mechanisms by which genomes, the environment, and their interactions contribute to phenotypic variation. (nature.com)
- Snapshot uses tens of thousands of SNPs across the genome to obtain very precise estimates of ancestry, even for admixed individuals. (parabon-nanolabs.com)
- We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. (ox.ac.uk)
Detect1
- Although a large part of South American zebu cattle also descend from taurine cows, we did not detect significant levels of taurine ancestry in these breeds, probably because of systematic backcrossing with zebu bulls. (biomedcentral.com)
Admixture1
- This analysis is robust to admixture, such that each piece of continental ancestry can be precisely localized within that continent. (parabon-nanolabs.com)
Hypertension1
- Reviewed literature showed that South Asians with HF were more likely to be younger and have diabetes and hypertension. (ox.ac.uk)
Characteristics2
- We grouped patients according to examined LN number (1-15 and 16+) and compared characteristics. (houstonmethodist.org)
- From the abstract: 'Precision prevention involves using the unique characteristics of a particular group to determine their responses to preventive interventions. (cdc.gov)
East5
- There is an emergent literature suggesting that East Asians and Westerners differ in cognitive processes because of cultural biases to process information holistically (East Asians) or analytically (Westerners). (illinois.edu)
- These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D. (ox.ac.uk)
- Below is an example plot for an individual who was determined to be 50% East Asian and 50% Latino. (parabon-nanolabs.com)
- The researchers found that during the Kofun period, people with East Asian ancestry, most likely Han Chinese, migrated to Japan and added their genes to those of the Jomon and Yayoi. (archaeology.org)
- Most Indo-Guyanese trace their ancestry to the mid-1800s, when (East) Indian indentured servants were brought to Guyana, an English-speaking, continental West Indian country formerly known as British Guiana (1). (cdc.gov)
Quantitative1
- A very important new article by a group of Greek and Chinese researchers provides the first quantitative assessment of mental processing in two groups of students, aged 8 to 14, belonging to the Caucasoid and Mongoloid races. (blogspot.com)
Race2
- Recent genetic research indicates that the degree of genetic heterogeneity within groups and homogeneity across groups make race per se a less compelling predictor. (bvsalud.org)
- While United maintained that no passenger was ever removed from a flight or denied boarding under unlawful circumstances, the investigation revealed that United unlawfully removed passengers from flights or denied boarding to passengers based on their race, color, national origin, religion or ancestry. (adc.org)
Asia1
- Around 17,000 years ago, sea levels rose, submerging the land bridge and isolating the Jomon from continental Asia for millennia, until agriculturalists arrived starting around 3,000 years ago and developed the Yayoi culture. (archaeology.org)
Methods1
- Methods: We retrospectively collected 15818 raw digital mammograms from 3772 Asian women aged 35-80 years who underwent screening or diagnostic mammography between Jan 2012 and Dec 2014 at our center. (um.edu.my)
Analysis1
- The aim of this study was to perform candidate gene analysis in HSP-TCC subjects from Asian families and to characterize disruption of spatacsin function during zebrafish development. (ox.ac.uk)