Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.ArthritisArthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Arthritis, Infectious: Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.Arthritis, Juvenile: Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.Arthritis, Psoriatic: A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.Arthritis, Reactive: An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.Synovial Membrane: The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.Joints: Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.Synovial Fluid: The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.Arthritis, Gouty: Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.Rheumatoid Factor: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.Mice, Inbred DBASynovitis: Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Rats, Inbred LewAutoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Blood Sedimentation: Measurement of rate of settling of erythrocytes in anticoagulated blood.Injections, Intra-Articular: Methods of delivering drugs into a joint space.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Rheumatic Diseases: Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Arthrography: Roentgenography of a joint, usually after injection of either positive or negative contrast medium.Rheumatology: A subspecialty of internal medicine concerned with the study of inflammatory or degenerative processes and metabolic derangement of connective tissue structures which pertain to a variety of musculoskeletal disorders, such as arthritis.Knee Joint: A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.Metacarpophalangeal Joint: The articulation between a metacarpal bone and a phalanx.Spondylitis, Ankylosing: A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Peptides, Cyclic: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Gold Sodium Thiomalate: A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.Wrist Joint: The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).Rheumatoid Nodule: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).HLA-DRB1 Chains: A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.Finger Joint: The articulation between the head of one phalanx and the base of the one distal to it, in each finger.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Tarsal Joints: The articulations between the various TARSAL BONES. This does not include the ANKLE JOINT which consists of the articulations between the TIBIA; FIBULA; and TALUS.Lyme Disease: An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.HLA-DR4 Antigen: An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Joint DiseasesHLA-DR Antigens: A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.CitrullineCytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Spondylarthropathies: Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.Foot Joints: The articulations extending from the ANKLE distally to the TOES. These include the ANKLE JOINT; TARSAL JOINTS; METATARSOPHALANGEAL JOINT; and TOE JOINT.Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Ankle Joint: The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Interleukin-17: A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.Freund's Adjuvant: An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.Tarsus, Animal: The region in the hindlimb of a quadruped, corresponding to the human ANKLE.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Tenosynovitis: Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.HLA-B27 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Organogold Compounds: Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Hand Joints: The articulations extending from the WRIST distally to the FINGERS. These include the WRIST JOINT; CARPAL JOINTS; METACARPOPHALANGEAL JOINT; and FINGER JOINT.Glucose-6-Phosphate Isomerase: An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.Disability Evaluation: Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Interleukin-6: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Interleukin-1: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Interleukin 1 Receptor Antagonist Protein: A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It supports research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress. It was established in 1986.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Mice, Inbred C57BLCase-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.Borrelia burgdorferi: A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Hindlimb: Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)Yersinia Infections: Infections with bacteria of the genus YERSINIA.Arthralgia: Pain in the joint.Spondylarthritis: Inflammation of the joints of the SPINE, the intervertebral articulations.Autoimmunity: Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Toe Joint: The articulation between the head of one phalanx and the base of the one distal to it, in each toe.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Hand Deformities, Acquired: Deformities of the hand, or a part of the hand, acquired after birth as the result of injury or disease.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Bone Resorption: Bone loss due to osteoclastic activity.Matrix Metalloproteinase 3: An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)Interleukin-1beta: An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Felty Syndrome: A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Hand: The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Sternoclavicular Joint: A double gliding joint formed by the CLAVICLE, superior and lateral parts of the manubrium sterni at the clavicular notch, and the cartilage of the first rib.Inflammation Mediators: The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).Metatarsophalangeal Joint: The articulation between a metatarsal bone (METATARSAL BONES) and a phalanx.Auranofin: An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Protein Tyrosine Phosphatase, Non-Receptor Type 22: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.Gout: Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Spondylitis: Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.Osteitis: Inflammation of the bone.Mice, Inbred BALB CArthritis-Encephalitis Virus, Caprine: A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), closely related to VISNA-MAEDI VIRUS and causing acute encephalomyelitis; chronic arthritis; PNEUMONIA; MASTITIS; and GLOMERULONEPHRITIS in goats. It is transmitted mainly in the colostrum and milk.Biological Therapy: Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Health Status: The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.Epitopes: Sites on an antigen that interact with specific antibodies.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Early Diagnosis: Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Th17 Cells: Subset of helper-effector T-lymphocytes which synthesize and secrete IL-17, IL-17F, and IL-22. These cytokines are involved in host defenses and tissue inflammation in autoimmune diseases.Activities of Daily Living: The performance of the basic activities of self care, such as dressing, ambulation, or eating.Aurothioglucose: A thioglucose derivative used as an antirheumatic and experimentally to produce obesity in animals.Bone Diseases: Diseases of BONES.Disease Susceptibility: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.Borrelia burgdorferi Group: Gram-negative helical bacteria, in the genus BORRELIA, that are the etiologic agents of LYME DISEASE. The group comprises many specific species including Borrelia afzelii, Borellia garinii, and BORRELIA BURGDORFERI proper. These spirochetes are generally transmitted by several species of ixodid ticks.Sialoglycoproteins: Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Spleen: An encapsulated lymphatic organ through which venous blood filters.Arthrodesis: The surgical fixation of a joint by a procedure designed to accomplish fusion of the joint surfaces by promoting the proliferation of bone cells. (Dorland, 28th ed)Range of Motion, Articular: The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.Arthroplasty, Replacement: Partial or total replacement of a joint.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Immunologic Factors: Biologically active substances whose activities affect or play a role in the functioning of the immune system.Immunoconjugates: Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.Joint Prosthesis: Prostheses used to partially or totally replace a human or animal joint. (from UMDNS, 1999)Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Stifle: In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.Arthroplasty: Surgical reconstruction of a joint to relieve pain or restore motion.Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)Tuberculosis, Osteoarticular: Tuberculosis of the bones or joints.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Foot Deformities, Acquired: Distortion or disfigurement of the foot, or a part of the foot, acquired through disease or injury after birth.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Elbow Joint: A hinge joint connecting the FOREARM to the ARM.Interleukin-10: A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Receptors, IgG: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Atlanto-Axial Joint: The joint involving the CERVICAL ATLAS and axis bones.Matrilin Proteins: PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.Hip Joint: The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Arthroscopy: Endoscopic examination, therapy and surgery of the joint.Chondrocalcinosis: Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)Matrix Metalloproteinases: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Sacroiliac Joint: The immovable joint formed by the lateral surfaces of the SACRUM and ILIUM.Hand Bones: The CARPAL BONES; METACARPAL BONES; and FINGER PHALANGES. In each hand there are eight carpal bones, five metacarpal bones, and 14 phalanges.Terpenes: A class of compounds composed of repeating 5-carbon units of HEMITERPENES.Aggrecans: Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Bursa, Synovial: A fluid-filled sac lined with SYNOVIAL MEMBRANE that provides a cushion between bones, tendons and/or muscles around a joint.

*  Diagnosing Rheumatoid Arthritis

More About Rheumatoid Arthritis. Aggressive RA Treatment May Prevent Joint Deformities. Thanks to earlier diagnosis and more ... Symptoms of rheumatoid arthritis (RA) don't stop at joint pain and swelling. Most people with RA also experience mental and ... More About Rheumatoid Arthritis. Aggressive RA Treatment May Prevent Joint Deformities. Thanks to earlier diagnosis and more ... Symptoms of rheumatoid arthritis (RA) don't stop at joint pain and swelling. Most people with RA also experience mental and ...

*  FDA OKs Cimzia for Rheumatoid Arthritis

The FDA has approved the Crohn's disease drug Cimzia to treat moderate to severe rheumatoid arthritis in adults, says the ... the FDA approved Cimzia to treat rheumatoid arthritis based on clinical trials in which more than 2,300 rheumatoid arthritis ... May 19, 2009 -- The FDA has approved the Crohn's disease drug Cimzia to treat moderate to severe rheumatoid arthritis in adults ... FDA OKs Cimzia for Rheumatoid Arthritis. Cimzia Already Used as a Treatment for Crohn's Disease ...

*  Green Tea May Ease Rheumatoid Arthritis - ABC News

To learn more about rheumatoid arthritis, visit the Arthritis Foundation.. SOURCES: Salah-uddin Ahmed, Ph.D., research ... About 2.1 million Americans have rheumatoid arthritis, according to the Arthritis Foundation. ... The new research by Ahmed is one of the first to focus on rheumatoid arthritis and green tea, Hsu said. If it bears out, it ... In patients with rheumatoid arthritis, this lining is inflamed, leading to long-term joint damage and chronic pain. ...

*  Planning treatment for rheumatoid arthritis | The BMJ

Planning treatment for rheumatoid arthritis. Br Med J 1977; 1 doi: (Published 28 May ...

*  Rheumatoid Arthritis: 8 Diet Tips for Relief

Can food help ease your rheumatoid arthritis? WebMD's selection can add relief and flavor to your diet. ... Food might not be the first thing on your mind when you have the stiffness, swelling, and pain of rheumatoid arthritis (RA). ... The inflammation associated with rheumatoid arthritis can raise your chances of heart disease, so adding healthy fats to your ... and minerals not found in refined versions that make them more beneficial for those with arthritis," Sandon says. Whole grains ...

*  Rheumatoid Arthritis

Information for patients and caregivers on rheumatoid arthritis (RA): what it is, causes, getting diagnosed, treatment options ... Rheumatoid Arthritis Fast Facts. *Rheumatoid arthritis (RA) is the most common type of autoimmune arthritis. It is caused when ... What is rheumatoid arthritis?. RA is the most common form of autoimmune arthritis. It affects more than 1.3 million Americans. ... People have long feared rheumatoid arthritis (commonly called RA) as one of the most disabling types of arthritis. The good ...

*  Rheumatoid Arthritis slideshows |

Rheumatoid Arthritis Slideshows. *Green around the Gills: Dealing with Nausea in Chronic Illness ... Top 10 Challenges of Living with Rheumatoid Arthritis as an Invisible Illness ... What Does Rheumatoid Arthritis Feel Like?. *5 Gift Ideas for People with Rheumatoid Arthritis ... 10 Ways to Make Daily Life Easier with Arthritis. * ... The ABCs of Rheumatoid Arthritis. *Facts About Vitamin D and ...

*  Rheumatoid Arthritis - Essential Health Information | HealthCentral

Ask an arthritis question, find support, or get the latest news on rheumatoid arthritis drugs and research. ... Learn about Rheumatoid Arthritis symptoms, treatment and medication. ... Gluten Free Diet for Rheumatoid Arthritis Can a gluten-free diet cure chronic illness without side effects? ...

*  FDA Approves Humira for Rheumatoid Arthritis

... is used to treat rheumatoid arthritis. Includes Humira side effects, interactions and indications. ... FDA Approves Humira for Rheumatoid Arthritis. Share on Facebook Share on Twitter Share on GooglePlus Print this page Email to a ... and improving physical function in adult patients with moderate to severe rheumatoid arthritis. Posted: December 2002 ... Abbott Receives FDA Approval for Humira (Adalimumab) for Polyarticular Juvenile Idiopathic Arthritis - February 22, 2008 ...

*  New 'bouncer' molecule halts rheumatoid arthritis | EurekAlert! Science News

When the scientists injected a mimic of P21 into an animal model of arthritis, the disease process was halted. ... Northwestern researchers have discovered why immune cells of people with rheumatoid arthritis become hyperactive and attack the ... New 'bouncer' molecule halts rheumatoid arthritis. Northwestern University. Journal. Arthritis & Rheumatism. Funder. National ... Existing treatments for rheumatoid arthritis include low-level chemotherapy and steroids. These are not always effective, ...

*  Rheumatoid Arthritis Joints Affected Hand Curcumin Turmeric * Arthritis Climwatadapt

Poster Presentation at the Annual Meeting of the Association of Schools of Allied Health Professions Orlando FL October 2013 Title: Management of Osteoarthritis and Rheumatoid Arthritis gout inflammatory arthritis . Shane Koyczan The Crickets Have Arthritis Words Aloud 2007 Canada. Shane Koyczan performs dog arthritis herbal treatment wrist brace rheumatoid at the Words Aloud 4 Spoken Word Festival in Durham.. Arthritis lock diflucan pill worsening symptoms is fluconazole from petsmart safe. Juvenile rheumatoid arthritis case study genetic alliancerheumatoid arthritis - genetic allianceclinical trials - medlineplus health informationrheumatoid Rheumatoid Arthritis Joints Affected Hand Curcumin Turmeric arthritis. Antibody tests help in ...

*  Rheumatoid Arthritis|Psoriatic Arthritis Symptoms|Arthritis Treatment: Help out with Arthritis Pain - Basal Combined Arthritis

Basal joint Arthritis is Arthritis all of the thumb. The basal joint is identified as thumb CMC (carpometacarpal) joints. This joint receives a whole lot of stress especially with pinching motions. The amount of pressure consumed this joint when to learn, using a pinch amongst the thumb and index ring finger, is approximately 6 big t 9 pounds of pressure for every 1 pound of a bit. It's no wonder this kind of joint wears out possesses so many arthritic malfunction. Arthritis in the basal joints is usually one of many types of Arthritis. Established types of Arthritis impacting on this joint are OsteoArthritis, Rheumatoid Arthritis, you should traumatic Arthritis. Traumatic Arthritis generally happens regarding injury of the articulation. OsteoArthritis is a degenerative Arthritis. Rheumatoid ...

*  Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort | Annals of the...

We have undertaken a comprehensive analysis testing established RA susceptibility loci for association with PsA. We have found significant evidence for association with the REL locus and nominal evidence for association with seven other RA susceptibility SNPs. Interestingly, for three of the eight PsA-associated variants, the risk allele is opposite to that reported in RA.. Given the phenotypic similarities between RA and PsA, it was expected that some genetic overlap would be observed as the concept is well established for autoimmune diseases such as RA, systemic lupus erythematosus and type 1 diabetes.2 ,3 However, it could also be argued that inflammatory arthritis may be an outcome of different immune responses in joints caused by different triggers with different underlying genetic susceptibility. Indeed, enthesitis is thought to be the primary abnormality in PsA by many researchers, with synovitis being a secondary phenomenon, in contrast to RA where the synovitis takes primacy. The ...

*  Responsiveness to anti-tumour necrosis factor α therapy is related to pre-treatment tissue inflammation levels in rheumatoid...

Objective: The response of rheumatoid arthritis (RA) patients to treatment with neutralising antibodies to tumour necrosis factor α (TNFα) is highly variable. The underlying mechanism for therapy responsiveness is currently unknown. We therefore evaluated the relationship between baseline molecular profiles of synovial tissues from RA patients and the clinical response to treatment with infliximab.. Methods: Synovial biopsies were obtained by arthroscopy from 18 RA patients with active disease (28 joint count Disease Activity Score (DAS28)⩾3.2) before initiation of treatment with infliximab. All patients were on stable methotrexate treatment. Clinical response at 16 weeks was defined as a reduction in DAS28 of ⩾1.2, non-response as reduction in DAS28 ,1.2. Large-scale gene expression profiling using microarrays was performed on synovial tissue samples. To identify biological processes in synovial biopsies that could discriminate between responders and non-responders, we ...

*  Comparison of composite measures of disease activity in an early sero-positive rheumatoid arthritis cohort | Annals of the...

Objective: To evaluate concordance and agreement of the original DAS44/ESR-4 item composite disease activity status measure with 9 simpler derivatives when classifying patient responses by European League of Associations for Rheumatology(EULAR) response, using an early rheumatoid factor positive(RF+) rheumatoid arthritis(RA) patient cohort. Methods: DMARD-naïve RF+ RA patients(n=223,mean duration of symptoms,6 months) were categorized as ACR none/20/50/70 responders. One-way analysis of variance and two sample t-tests were used to investigate the relationship between the ACR response groups and each composite measure. EULAR reached/change cut-point scores were calculated for each composite measure. EULAR(good/moderate/none) responses for each composite measure and the degree of agreement with DAS44/ESR-4 item were calculated for 203 patients. Results: Patients' were mostly female(78%) with moderate to high disease activity. A percentile-based nomogram ...

*  Associations between the PTPN22 1858C→T polymorphism and radiographic joint destruction in patients with rheumatoid arthritis:...

Objective: To investigate whether the PTPN22 1858T risk variant is associated with the rate of radiographic progression in rheumatoid arthritis (RA).. Methods: A longitudinally followed cohort of 238 Norwegian patients with RA (the EURIDISS cohort) was genotyped for the PTPN22 1858C→T polymorphism. Radiographic damage was assessed by hand radiographs at baseline and after 1, 2, 5 and 10 years, and the radiographs were scored with the Sharp method modified by van der Heijde (Sharp-van der Heijde score) by a single experienced reader. Baseline serum levels of rheumatoid factor and anti-cyclic citrullinated peptide autoantibodies were also examined.. Results: The reported association between RA susceptibility and carriage of the T allele (34.4% in patients vs 21.4% in controls; odds ratio 1.92, 95% confidence interval 1.36 to 2.71, p = 0.0002) was confirmed. An association between annual progression rate of Sharp-van der Heijde score and T-allele carriers (p = ...

*  Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis | Annals of...

Results Significant dose-response relationships were found between Body Mass Index (BMI) and change of disease activity as well as pain at both time points. Patients with BMI ≥25 had 51% lower odds of achieving low disease activity (odds ratio (OR=0.49 (95% CI 0.31 to 0.78)) and 42% lower odds of remission (OR=0.58 (95% CI 0.37 to 0.92)) at the 6-months visit, compared to normal-weight patients. This effect was also present at 3 months, where we also found a 43% decreased odds of pain remission (OR=0.57 (95% CI 0.37 to 0.88)). No effect modification was found for anti-citrullinated protein antibody (CCP)-status, sex, prednisolone treatment or DAS28 at diagnosis.. ...

*  SAT0218 Effect of tocilizumab in DMARD-NAÏVE early rheumatoid arthritis patients on health-related quality of life: results of...

Methods Patients (n=317) were randomized to initiate TZC, TCZ+MTX or MTX therapy and treated according to a step-up strategy. TCZ was given (8 mg/kg) every 4 weeks and MTX (oral) was started at 10 mg/week and increased with steps of 5 mg steps 4 weekly up to 30 mg/week (or maximum tolerable dose) until remission. If after 20 weeks remission was not achieved, hydroxychloroquine was added and discontinued 12 weeks thereafter if the target still was not achieved. Patients who originally initiated monotherapy then switched to TCZ+MTX therapy and those already on this combination therapy switched to a tumour necrosis factor inhibitor. To evaluate the effect of TCZ on HRQoL, we used the 36-item Short-Form (SF-36), which can be summarized into a physical (PCS) and mental (MCS) component score. HRQoL was measured at baseline and after 12, 24, 52, and 104 weeks. A linear mixed effect model with a random intercept was used to evaluate differences between treatment strategies over time with visit (time), ...

*  Rheumatoid Arthritis|Psoriatic Arthritis Symptoms|Arthritis Treatment: Rheumatoid Arthritis and his awesome Foot

Rheumatoid Arthritis (RA) is mostly a systemic disease that sinks in about 2. 1 billion Americans, mostly women and has been show to attack multiple joints surrounding the body. It is approximated that 1. 5 million women and 600, 000 men are victims of this debilitating disease. Of my favorite affected, approximately 90% of the individuals with RA eventually place foot or ankle Symptoms regarding deformity. In fact, many early Symptoms of RA often include foot problems. Foot problems are more common than Symptoms to hand and only now to knee problems. These Symptoms can get serious disability. The exact source of RA is still top secret, even with years for the study. Some possible results in include inheritance from tourists, chemical or environmental "triggers" all ahead of the malfunction of the immune system. In RA, the immune part of the body turns against entirely and damages joints causing you cartilage damage and redness. Symptoms. Symptoms often begin along with ...

*  OP0033 Rheumatoid Factor and Anti-Citrullinated Protein Antibody Positivity, but not Their Concentration, Are Associated with...

Methods Data from the Norfolk Arthritis Register (NOAR) and Leiden Early Arthritis Clinic (EAC) cohort were used. At baseline, patients had demographic data and smoking status recorded; RF, ACPA and inflammatory markers were measured in the local laboratories. Patients were flagged with national death registers until death or censor date. Antibody status was stratified as negative, low or high positive as defined in the 2010 criteria, firstly by either RF or ACPA level, secondly by RF level alone and thirdly by ACPA level alone. Finally, patients were grouped as seronegative, single antibody positive or double antibody (RF and ACPA) positive. Cox regression models were applied to explore associations between antibody status and mortality adjusting for age, sex, smoking status, inflammatory markers and year of enrolment.. ...

*  Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight...

Objective To evaluate toxicity profiles in patients with rheumatoid arthritis (RA) treated either according to an intensive or a conventional treatment strategy approach with methotrexate (MTX) and to study factors associated with MTX-related toxicity.. Methods Data were used from the Computer-Assisted Management in Early Rheumatoid Arthritis (CAMERA) study, in which clinical efficacy of an intensive treatment strategy with MTX was more beneficial than a conventional treatment strategy approach. In this study, data on adverse events (AEs) were compared between the two strategy groups. Logistic regression analyses were used to identify possible associations between factors assessed at baseline and withdrawal due to MTX-related AEs or liver toxicity at follow-up.. Results Although significantly more patients in the intensive strategy group experienced MTX-related AEs than in the conventional strategy group, all recorded AEs were relatively ...

*  Ask an Expert: Rheumatoid Arthritis Treatments

Yes, there are many agents that are being explored as therapeutics for Rheumatoid Arthritis (RA). Whether or not these agents will have the appropriate balance of effectiveness and safety is unknown. Two agents that relatively mature in their investigational process have different mechanisms of action. One agent inhibits the effect of an inflammatory cytokine known as IL-6. If FDA-approved, it would be the first medicine of its kind to treat RA with this mechanism of action. Another agent inhibits the effect of TNF-alpha, similar to adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade). This agent is already FDA-approved for the treatment of an inflammatory bowel disease known as Crohn's Disease. ...

*  A2.12 Increased CXCR5 B cell expression, CXCL13 and SCD23 serum levels in untreated early rheumatoid arthritis patients support...

Results The frequency of total CD19+ B-cells in circulation was similar between controls and patients' groups, but established RA had significantly increased frequencies of double negative (IgD-CD27-) B-cells in comparison with controls. CXCR5 B-cell expression was significantly increased in both ERA and established RA in comparison with controls, but no significant differences were observed in BAFF-R, TACI, BCMA, CD69, CD86, HLA-DR, TLR9, CD95, IgM and CD5 B-cell expression between all groups analysed. Furthermore, alterations in B-cell gene expression levels were found in BAFF-R, TACI, TLR9, FcγRIIB, BCL-2, BLIMP-1 and β2M in ERA and established RA patients when compared to controls, but no significant differences were detected in AID, BCMA, CXCR5, TLR7 and TLR10 B-cell gene expression between all groups. In addition, CXCL13 and sCD23, but not BAFF serum levels, were significantly increased since early RA. ...

*  Heart disease and rheumatoid arthritis: understanding the risks | Annals of the Rheumatic Diseases

Patients with rheumatoid arthritis (RA) are at increased risk of mortality compared with the general population. Evidence suggests that this increased mortality can largely be attributed to increased cardiovascular death. In a retrospective study of an inception cohort of RA patients in Rochester, MN, the contribution of traditional and RA-specific risk factors was investigated to this increased risk of cardiovascular morbidity and mortality. Several traditional cardiovascular risk factors were found to behave differently in RA patients. In addition, their associations with cardiovascular disease are weaker in RA patients as increased inflammation associated with RA also appears to contribute substantially to the increased cardiovascular mortality. Furthermore, the impact of disease-modifying antirheumatic drugs and biologicals on cardiovascular disease in RA patients is unclear. Cardiovascular risk scores for the general population may underestimate the risk for RA ...

*  IgE and IgE-rheumatoid factors in circulating immune complexes in rheumatoid arthritis. | Annals of the Rheumatic Diseases

The sera of 21 patients with rheumatoid arthritis (RA), 11 patients with systemic lupus erythematosus (SLE), and 20 healthy subjects were analysed for the presence of IgE in immune complex fractions. These fractions were isolated by polyethylene glycol precipitation and gel filtration. Thirteen sera from RA patients contained IgE immune complexes (IC) and 11 of these were from patients with extra-articular manifestations. One SLE and none of the control sera contained such material. The serum IgE level did not correlate with IgE content of the IC fractions. Higher mean serum IgE levels were found in RA patients with extra-articular complications than in controls or RA patients with joint disease only, but the differences did not reach statistical significance. IgE anti-rabbit IgG (IgE rheumatoid factors) could be demonstrated in some IgE positive IC fractions. Antibodies to IgE, in 2 instances characterised as belonging to IgG class, were also found in ICs. ...

*  Sleep and Immunity in Rheumatoid Arthritis : Remicade Substudy - Full Text View -

Abnormal sleep is reported by more than half of rheumatoid arthritis patients, in addition to the traditional symptoms associated with the disease, such as morning stiffness, pain, and functional debility. When recording brain activity during sleep using electroencephalography or EEG. Sleep abnormalities have been found independent of pain and thus the mechanisms to account for disordered sleep in this population are unknown. The immune system, via pro-inflammatory cytokines, plays a major role in the development of rheumatoid arthritis. Pro-inflammatory cytokines are molecules that act as signals to stimulate activity of different arms of the immune system. New medications such as remicade (infliximab) have been developed which slow disease activity by blocking the activity of these pro-inflammatory cytokines. This is done by binding to the cytokine TNF and rendering it biologically inactive. Pro-inflammatory cytokines also appear to play a ...

*  Rheumatoid Arthritis|Psoriatic Arthritis Symptoms|Arthritis Treatment: Arthritis in a Cats - A Conquerable Infirmity

The most common strategy to detect the Symptoms of Arthritis in cats is the place where he has difficulty taking walks or standing for hours on end. Limping and strolling the actual stilted gait are amongst the telltale signs that something is definitely wrong. The individuality of social apathy, aggression, and withdrawal oftentimes carry on suit, although those clues can be bit harder to notice at first glance. One thing to consider: For those with Arthritis, cat's Treatment is different from human pain remedies, especially in the case of Arthritis in cats. What may work for humans very well may be harmful to felines, so medication (unless accredited and administered by the vet) is required sparingly. For Arthritis, cat's Treatment and prevention is very simple, such as: If your cat turns into a fat cat, then he probably does not exercise as many as he should. Regular exercise keeps one's feline busy and simultaneously, maintains a proper ...

*  AB0027 Impact of additional genetic markers of rheumatoid arthritis on pattern of functional stress responses | Annals of the...

Results There was a highly significant distortion in the distribution of the beta2AR polymorphism at codon 16 between RA patients and controls, contributing to the genetic background of RA. Arginine (Arg) at codon 16 was present in 89.7% of RA patients compared to 66.2% controls (OR 4.43, 95% CI 2.81 to 7.02, p=0.00001). Stratifying RA patients for the amino acid sequence at position 16 and their autonomic reactivity revealed a statistically significant decrease of parasympathetic activity, in particular for the deep breathing test, in patients with homozygosity for Glycine (Gly) 16 compared to RA patients being heterozygous (Arg16Gly). However, RA patients with homozygosity for Glycine 16 showed a normalisation of the sympathetic reactivity upon mental stress test. It could be also demonstrated that in RA patients the autonomic response to minor stress is characterised by a disturbance of sympathetic as well as parasympathetic activity which is associated with disease activity. On the other ...

*  Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis | Annals of the...

MIP-1α, which is a member of the C-C chemokine family, is a lipopolysaccharide (LPS) inducible, heparin binding polypeptide first isolated from LPS treated murine RAW 264.7 cells.26-28 In a recent study, we showed that MIP-1α was present in arthritic joints during the evolution of murine collagen induced arthritis (CIA), an experimental model of RA; moreover, exacerbation of CIA could be prevented by administration of neutralising anti MIP-1α antibodies.22 This strongly suggests that MIP-1α plays a pivotal part in the development of RA.. Chemokines (for example, IL8, MCP-1, and MIP-1α) are readily detectable in rheumatoid SF, and their values correlate with RA disease activity.25 29-32 These findings led us to speculate that the presence of chemokines in rheumatoid SF might, in part, depend on SF neutrophils, which are the principal cell type accumulated in the SF of RA patients. The main finding of this study was that freshly isolated RA SF neutrophils ...

*  Rheumatoid Arthritis|Psoriatic Arthritis Symptoms|Arthritis Treatment: Are you affected by OsteoArthritis? Here's How to share!

The most everyday sort of Arthritis is OsteoArthritis (OA). This type of Arthritis is typically called wear and tear Arthritis or degenerative Arthritis. ". While this condition probably begins noisy . teen years, it does not become symptomatic until be reaches their 40's. OsteoArthritis is affecting cartilage, the slippery elastic tissue that is designed ends of long ribs. Cartilage functions to absorb shock from movement and just provide a gliding surface at your joints. With OA, the cartilage begins to wear away and the valid bones begin to rub in unison. This leads to problem. As OS progresses, it causes swelling and obtaining motion. Bone spurs develop together with the joint starts to deform. Microscopic particles of cartilage and bone slough off and cause irritation considering all of joint lining leading to more inflammation that leads to pain and more harm. Symptoms of OA provide you pain or ...

*  Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation | Arthritis Research & Therapy |...

Fibroblast-like synoviocytes have been shown to play a central role in defining the stromal environment in inflammatory joint diseases and to be mediators of joint destruction and persistent inflammation [26, 35, 36]. To date, extensive research has been performed using human FLS isolated from synovial tissue from patients undergoing joint arthroplasty. These cells have been well characterised in multiple disease states, including RA, osteoarthritis, psoriatic arthritis, juvenile onset arthritis and crystal arthropathy [34, 37]. In contrast, despite a growing use of FLS isolated from murine inflammatory models, a similar thorough characterisation of mouse FLS has yet to be performed. In the present study, we successfully isolated FLS from K/BxN mice and characterised multiple inflammatory markers. Cells were characterised on multiple criteria to provide the best confirmation of their origin and purity. These included general stromal fibroblast markers such ...

*  Influence of Complications on Therapeutic Goal in Rheumatoid Arthritis. | Annals of Internal Medicine | American College of...

Rehabilitation of the patient with rheumatoid arthritis is exceptionally difficult because of the severe mechanical limitation produced by joint deformities and the uncertain course of the disease activity. Furthermore, the disease or its treatment make the rheumatoid patient susceptible to infections and other complications that may threaten his life or delay his long-term rehabilitation.. During a 5-year period, of 101 patients with rheumatoid arthritis admitted for rehabilitation and followed from 1 to 4 years, 26 died and 19 others had major complications. Death was due to Gram-negative sepsis in four; pneumonia, four; bacteroides arthritis, one; gastrointestinal hemorrhage, two; diffuse vasculitis, ...

*  Arthritis Treatment: Is There a Part for Sulfa Medicines in Dealin ... | Dmards

The process to treating inflammatory forms of arthritis relies upon on a multitude of reasons. These can include the choice of arthritis, the adventure of the practitioner, the age of the client, probable confounding components these as allergies, duration of time the client has experienced the arthritis, earlier medicine tried out, and no matter whether the prescription drugs are to be put into use a particular at a time or "layered" on top rated of each other.. For illustration, a condition like rheumatoid arthritis demands aggressive treatment with a sickness modifying anti-rheumatic drug (DMARD) this sort of as methotrexate. Methotrexate tends to give good results properly to gradual disease. Regardless, initiation of methotrexate is just the first of all action. This is rather quickly followed by both the addition of a biologic drugs or by incorporating other DMARDs.. In contrast, a disorder like psoriatic ...

*  B cell signature contributes to the prediction of RA development in patients with arthralgia | Annals of the Rheumatic Diseases

Early recognition followed by treatment of rheumatoid arthritis (RA) helps to maintain joint integrity and functional capacity,1 suggesting it may be beneficial to intervene in patients with arthralgia before RA develops. Anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are established predictive markers,2 ,3 but only 20-40% of ACPA and/or RF positive patients with arthralgia develop RA within 2 years.4 Recently, we have demonstrated that the type I interferon (IFN) signature correctly identifies 52% of patients with arthralgia who will develop RA within 2 years.5 ,6 Our previous study suggested that a B cell related gene signature was associated with protection against arthritis development,6 and could aid in the prediction of arthritis development. We therefore studied the clinical value of the B cell signature, comprising CD19, CD20, CD79α and CD79β, for the prediction of arthritis ...

ACR score for rheumatoid arthritis: ACR score is a scale to measure change in rheumatoid arthritis symptoms. It is named after the American College of Rheumatology.Arthritis Research UKViral arthritis (poultry): Viral arthritis}}Childhood arthritisDactylitis: Dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful.Reactive arthritisFibroblast-like synoviocyte: Fibroblast-like synoviocytes (FLS) represent a specialised cell type located inside joints in the synovium. These cells play a crucial role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis.Dredge ball joint: A dredge ball joint is a connection between two pipes that are used to transport a mixture of water and sand from a dredger to the discharging area.Rheumatoid factor: Rheumatoid factor (RF) is the autoantibody (antibody directed against an organism's own tissues) that was first found in rheumatoid arthritis. It is defined as an antibody against the Fc portion of IgG (an antibody against an antibody).Remitting seronegative symmetrical synovitis with pitting edema: Remitting seronegative symmetrical synovitis with pitting edema (abbreviated RS3PE or sometimes RS3PE) is a rare syndrome identified by symmetric polyarthritis, synovitis, acute pitting edema (swelling) of the back of the hands and/or feet, and a negative serum rheumatoid factor. If no underlying disorder can be identified (idiopathic RS3PE), this entity has an excellent prognosis and responds well to treatment.Osteoarthritis Research Society International: The Osteoarthritis Research Society International (OARSI) is a non-profit scientific organization.OARSI.Methotrexate-induced papular eruption: Methotrexate-induced papular eruption appears in patients being treated with methotrexate, such as those with rheumatic disease, presenting with erythematous indurated papules, usually located on the proximal extremities.James, William; Berger, Timothy; Elston, Dirk (2005).Autoantibody: An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases, (notably lupus erythematosus), are caused by such autoantibodies.Automated analyser: An automated analyser is a medical laboratory instrument designed to measure different chemicals and other characteristics in a number of biological samples quickly, with minimal human assistance.G-CSF factor stem-loop destabilising elementAnnals of the Rheumatic Diseases: The Annals of the Rheumatic Diseases is a peer-reviewed medical journal. It is co-owned by the BMJ Group and the European League Against Rheumatism and covers all aspects of rheumatology, including musculoskeletal conditions, arthritis, and connective tissue diseases.CD4 immunoadhesin: CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region.ArthrogramGerman Center for Pediatric and Adolescent Rheumatology: == History ==Knee pain: Knee pain is a common complaint for many people. There are several factors that can cause knee pain.Ulnar clawSpondylitisSulfasalazineAutoimmune diseaseMonoclonal antibody therapySodium aurothiomalateCollagenHeberden's nodeGross pathology: Gross pathology refers to macroscopic manifestations of disease in organs, tissues, and body cavities. The term is commonly used by anatomical pathologists to refer to diagnostically useful findings made during the gross examination portion of surgical specimen processing or an autopsy.Lisfranc injury: The Lisfranc injury (also known as the Lisfranc fracture, Lisfranc dislocation, Lisfranc fracture dislocation, tarsometatarsal injury, or simply midfoot injury) is an injury of the foot in which one or more of the metatarsal bones are displaced from the tarsus. The injury is named after Jacques Lisfranc de St.Lyme disease microbiology: Lyme disease, or borreliosis, is caused by spirochetal bacteria from the genus Borrelia, which has at least 37 known species, 12 of which are Lyme related, and an unknown number of genomic strains. Borrelia species known to cause Lyme disease are collectively known as Borrelia burgdorferi sensu lato.TACI-CRD2 protein domain: In molecular biology, this protein domain, TACI-CRD2 represents the second cysteine-rich protein domain found in the TACI family of proteins. Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are required for binding to the ligands APRIL and BAFF.Broad-Spectrum Chemokine Inhibitor: A Broad-Spectrum Chemokine Inhibitor or BSCI (also termed Chemotide or Somatotaxin ) is a type of experimental anti-inflammatory drug that inhibits the action of the pro-inflammatory proteins chemokines.CitrullineProinflammatory cytokine: A proinflammatory cytokine is a cytokine which promotes systemic inflammation.Psoriasis: (psora + -iasis)Articular cartilage repair: The aim of an articular cartilage repair treatment is to restore the surface of an articular joint's hyaline cartilage. Over the last decades, surgeons and researchers have been working hard to elaborate surgical cartilage repair interventions.Footballer's ankle: Footballer's Ankle is a pinching or impingement of the ligaments or tendons of the ankle between the bones, particularly the talus and tibia. This results in pain, inflammation and swelling.Inflammation: Inflammation (Latin, [is part of the complex biological response of body tissues to harmful stimuli, such as pathogen]s, damaged cells, or irritants.PMHC cellular microarray: PMHC cellular microarrays are a type of cellular microarray that has been spotted with pMHC complexes peptide-MHC class I or peptide-MHC class II.Peripheral edemaFreund: __NOTOC__Ancient road in Tarsus: Ancient road ( ) at ( extending to ) is the unearthed section of an ancient road in the historical city of Tarsus, Turkey.Eva Engvall: Eva Engvall, born 1940, is one of the scientists who invented ELISA in 1971.Eva Engvall, The Scientist 1995, 9(18):8Stenosing tenosynovitisHLA-B38: HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.Biomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.Organogold chemistry: Organogold chemistry is the study of compounds containing carbon-gold bonds. They are studied in academic research, but have not received widespread use otherwise.Combination therapy: Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone). Typically, these terms refer to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression).Glucose-6-phosphate isomerase: Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme that in humans is encoded by the GPI gene on chromosome 19.International Disability and Development Consortium: The International Disability and Development Consortium (IDDC) is a global consortium of disability and development related organisations. The aim of IDDC is to promote inclusive development internationally, with a special focus on promoting human rights for all disabled people living in economically poor communities in lower and middle-income countries.Cancer pain: Pain in cancer may arise from a tumor compressing or infiltrating nearby body parts; from treatments and diagnostic procedures; or from skin, nerve and other changes caused by a hormone imbalance or immune response. Most chronic (long-lasting) pain is caused by the illness and most acute (short-term) pain is caused by treatment or diagnostic procedures.Systemic lupus erythematosus and pregnancy: For women with systemic lupus erythematosus (SLE), pregnancy can present some particular challenges for both mother and child.Non-communicable disease: Non-communicable disease (NCD) is a medical condition or disease that is non-infectious or non-transmissible. NCDs can refer to chronic diseases which last for long periods of time and progress slowly.Interleukin 1 receptor antagonist: The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.Temporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingNested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.IsoxazolePrednisolonePenicillamineBorrelia burgdorferi: Borrelia burgdorferi is a bacterial species of the spirochete class of the genus Borrelia. B.SeroconversionProtective autoimmunity: Protective autoimmunity is a condition in which cells of the adaptive immune system contribute to maintenance of the functional integrity of a tissue, or facilitate its repair following an insult. The term ‘protective autoimmunity’ was coined by Prof.Pain scale: A pain scale measures a patient's pain intensity or other features. Pain scales are based on self-report, observational (behavioral), or physiological data.Dermal fibroblast: Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers.Osteoclast

(1/11580) Fitzgerald factor (high molecular weight kininogen) clotting activity in human plasma in health and disease in various animal plasmas.

Fitzgerald factor (high molecular weight kininogen) is an agent in normal human plasma that corrects the impaired in vitro surface-mediated plasma reactions of blood coagulation, fibrinolysis, and kinin generation observed in Fitzgerald trait plasma. To assess the possible pathophysiologic role of Fitzgerald factor, its titer was measured by a functional clot-promoting assay. Mean +/- SD in 42 normal adults was 0.99+/-0.25 units/ml, one unit being the activity in 1 ml of normal pooled plasma. No difference in titer was noted between normal men and women, during pregnancy, or after physical exercise. Fitzgerald factor activity was significantly reduced in the plasmas of eight patients with advanced hepatic cirrhosis (0.40+/-0.09 units/ml) and of ten patients with disseminated intravascular coagulation (0.60+/-0.30 units/ml), but was normal in plasmas of patients with other congenital clotting factor deficiencies, nephrotic syndrome, rheumatoid arthritis, systemic lupus erythematosus, or sarcoidosis, or under treatment with warfarin. The plasmas of 21 mammalian species tested appeared to contain Fitzgerald factor activity, but those of two avian, two repitilian, and one amphibian species did not correct the coagulant defect in Fitzgerald trait plasmas.  (+info)

(2/11580) Wasting of the small hand muscles in upper and mid-cervical cord lesions.

Four patients are described with destructive rheumatoid arthritis of the cervical spine and neurogenic wasting of forearm and hand muscles. The pathological connection is not immediately obvious, but a relationship between these two observations is described here with clinical, radiological, electrophysiological and necropsy findings. Compression of the anterior spinal artery at upper and mid-cervical levels is demonstrated to be the likely cause of changes lower in the spinal cord. These are shown to be due to the resulting ischaemia of the anterior part of the lower cervical spinal cord, with degeneration of the neurones innervating the forearm and hand muscles. These findings favour external compression of the anterior spinal artery leading to ischaemia in a watershed area as the likeliest explanation for this otherwise inappropriate and bizarre phenomenon.  (+info)

(3/11580) Overexpression of human homologs of the bacterial DnaJ chaperone in the synovial tissue of patients with rheumatoid arthritis.

OBJECTIVE: To study the expression of the chaperone family of J proteins in the synovial tissue of patients with rheumatoid arthritis (RA) or osteoarthritis. METHODS: Rabbit antibodies specific for a synthetic peptide (pHSJ1: EAYEVLSDKHKREIYD), representing the most conserved part of all J domains thus far identified--among them the Drosophila tumor suppressor Tid56--were used in immunohistochemical analyses of frozen sections of synovial tissue and immunoblotting of protein extracts of adherent synovial cells. IgG specific for Tid56 was also used. RESULTS: Both antisera predominantly and intensely stained synovial lining cells from RA patients; other cells did not stain or stained only faintly. In immunoblots, anti-pHSJ1 specifically detected several bands with molecular weights of >74 kd (type I), 57-64 kd (type II), 41-48 kd (type III), and < or =36 kd (type IV). The strongest band detected in RA adherent synovial cells was the type II band, whereas in a B cell line, a type I band was prominent. CONCLUSION: Several potentially new members of the J family are described. The type II band represents the human homolog of the Drosophila Tid56 protein and is strongly expressed in RA synovial tissue.  (+info)

(4/11580) Establishment and characterization of nurse cell-like stromal cell lines from synovial tissues of patients with rheumatoid arthritis.

OBJECTIVE: To investigate the features of synovial stromal cells established from patients with rheumatoid arthritis (RA), and to define these cells as nurse cells. METHODS: Synovial nurse-like stromal cell lines (RA-SNCs) were established from patients with RA. These cell lines were examined for morphology, pseudoemperipolesis activity, cell surface markers, and cytokine production. The interaction between these RA-SNCs and a synovial tissue B cell clone was also examined. RESULTS: RA-SNCs had nurse cell activity. They spontaneously produced interleukin-6 (IL-6), IL-8, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor. Furthermore, they produced IL-1beta and tumor necrosis factor alpha and expressed higher levels of the other cytokines after coculture with the B cell clone. Proliferation and Ig production by the B cell clone were dependent on direct contact with RA-SNCs. CONCLUSION: These results indicate that the RA-SNCs were nurse cells. The findings suggest that RA-SNCs may play an important role in the pathogenesis of RA by producing large amounts of cytokines and maintaining infiltrating lymphocytes.  (+info)

(5/11580) Economic consequences of the progression of rheumatoid arthritis in Sweden.

OBJECTIVE: To develop a simulation model for analysis of the cost-effectiveness of treatments that affect the progression of rheumatoid arthritis (RA). METHODS: The Markov model was developed on the basis of a Swedish cohort of 116 patients with early RA who were followed up for 5 years. The majority of patients had American College of Rheumatology (ACR) functional class II disease, and Markov states indicating disease severity were defined based on Health Assessment Questionnaire (HAQ) scores. Costs were calculated from data on resource utilization and patients' work capacity. Utilities (preference weights for health states) were assessed using the EQ-5D (EuroQol) questionnaire. Hypothetical treatment interventions were simulated to illustrate the model. RESULTS: The cohort distribution among the 6 Markov states clearly showed the progression of the disease over 5 years of followup. Costs increased with increasing severity of the Markov states, and total costs over 5 years were higher for patients who were in more severe Markov states at diagnosis. Utilities correlated well with the Markov states, and the EQ-5D was able to discriminate between patients with different HAQ scores within ACR functional class II. CONCLUSION: The Markov model was able to assess disease progression and costs in RA. The model can therefore be a useful tool in calculating the cost-effectiveness of different interventions aimed at changing the progression of the disease.  (+info)

(6/11580) Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension.

OBJECTIVE: To investigate the usefulness of hydroxychloroquine (HCQ) dose-loading to increase the percentage of responders or rate of response in treating rheumatoid arthritis (RA). METHODS: Two hundred twelve patients with early RA (mean duration 1.5 years) were enrolled in a 24-week trial. Patients were stabilized with 1,000 mg naproxen/day and then began a 6-week, double-blind trial comparing treatment with HCQ at 400 mg/day (n = 71), 800 mg/day (n = 71), and 1,200 mg/day (n = 66), followed by 18 weeks of open-label HCQ treatment at 400 mg/day. RESULTS: All patients had mild, active disease at the time of initiation of HCQ treatment (31-43% rheumatoid factor positive; no previous disease-modifying antirheumatic drugs; mean swollen joint count 8.6-10.4). Based on the Paulus criteria, response during the 6-week double-blind portion of the study was 47.97%, 57.7%, and 63.6% in the 400 mg/day, 800 mg/day, and 1,200 mg/day groups, respectively (P = 0.052). Discontinuations for adverse events were dose related (3 in the 400 mg/day group, 5 in the 800 mg/day group, 6 in the 1,200 mg/day group). Most involved the gastrointestinal (GI) system, with the background naproxen treatment possibly contributing. Ocular abnormalities occurred in 17 of 212 patients (8%) but were not dose related. CONCLUSION: Dose-loading with HCQ increased the degree of response at 6 weeks in this group of patients with early, predominantly seronegative RA. Adverse GI events were dose related, while adverse ocular events were not.  (+info)

(7/11580) Serum response elements activate and cAMP responsive elements inhibit expression of transcription factor Egr-1 in synovial fibroblasts of rheumatoid arthritis patients.

Analyzing the induction kinetics and promoter elements regulating the expression of the transcription factor Egr-1, we found elevated levels of Egr-1-encoding mRNA in synovial fibroblasts of rheumatoid arthritis (RA) patients when compared to controls. By contrast, synovial lymphocytes and macrophages do not show an elevated Egr-1 transcription. Therefore, the overexpression of Egr-1 may serve as a diagnostic marker to characterize synovial fibroblasts of RA patients. To study the regulatory mechanisms controlling Egr-1 expression we analyzed the function of transcription factor binding sites located in the Egr-1 promoter. Individual transcription factor binding sites within the Egr-1 promoter were specifically mutated and Egr-1 promoter activity was tested using reporter gene constructs. Our experiments demonstrate that serum response elements are the main positive regulators and binding to a cAMP responsive element represents the major negative regulator for Egr-1 expression in synovial fibroblasts. In addition, we functionally defined a new element, which was not yet described in the human Egr-1 promoter and which serves as a second negative regulatory element for Egr-1 expression. Therefore increased serum response factor activity or failure of Egr-1 repressing signals may account for Egr-1 overexpression in RA synovial fibroblasts.  (+info)

(8/11580) Survivorship and radiological analysis of the standard Souter-Strathclyde total elbow arthroplasty.

We undertook a radiological analysis of 186 standard Souter implants to determine survivorship and to analyse the pattern of failure in those needing revision. The implants had been inserted as a primary procedure in patients with rheumatoid arthritis of the elbow at our hospital over the last 12 years. Taking revision as an endpoint, the survivorship after 12 years was 87%. If, however, revision and loosening, defined as the Hindex value equivalent to demarcation of 1 mm around the whole implant, are also included, the survivorship falls to 80%. Of the 24 implants revised, 18 (75%) were for problems with the humeral component, three (12.5%) with the ulnar component and three (12.5%) for instability. Loosening of the humeral component occurred when the implant extended into the humerus, with the tip moving anteriorly on to the anterior humeral cortex. Our study indicates that loosening can be predicted by the rate of change in this angle of extension of the prosthesis.  (+info)

risk of developing rheumatoi

  • It turns out that those with these antibodies who also have a particular variety of HLA, a complex of genes that regulate immune function, have a 30 times higher risk of developing rheumatoid arthritis than those without these genetic risk factors. (


  • May 19, 2009 -- The FDA has approved the Crohn's disease drug Cimzia to treat moderate to severe rheumatoid arthritis in adults who have had an inadequate response to conventional therapy. (
  • Humira is a recombinant human IgGl monoclonal antibody specific for human tumor necrosis factor (TNF) indicated for reducing the signs and symptoms, inducing major clinical response, slowing the progression of joint damage, and improving physical function in adult patients with moderate to severe rheumatoid arthritis. (
  • Active Severe Rheumatory Arthritis. (
  • Reuters Health) - A study of people with rheumatoid arthritis (RA) finds that those in wealthy nations are more troubled by it, even though people in poor countries have more severe symptoms. (


  • MONDAY, April 30 (HealthDay News) -- Green tea, already touted for its cardiovascular and anticancer benefits, may also help ease the inflammation and pain of rheumatoid arthritis, a new study suggests. (
  • The inflammation associated with rheumatoid arthritis can raise your chances of heart disease , so adding healthy fats to your diet is good for more than your joints, Sandon says, who also has RA. (


  • The physical exam may reveal other signs, such as rheumatoid nodules or a low-grade fever. (

Crohn's Disease

  • Proceeds from the financing will be used to support the company's clinical trials to assess safety and efficacy of its bioelectronic therapy in rheumatoid arthritis (RA) and Crohn's Disease, and to help advance the therapy toward commercialization. (


  • Rheumatoid arthritis (RA) is the most common type of autoimmune arthritis. (
  • A rheumatologist is a doctor who treats arthritis and autoimmune disease. (
  • RA is the most common form of autoimmune arthritis. (
  • This will provide key insights into the pathways underlying rheumatoid arthritis and other autoimmune diseases. (
  • Identifying Immune System Mediators About one percent of the US population will develop rheumatoid arthritis, an autoimmune disease that leads to painful joint swelling. (
  • Over the last decade, Dr. Gregersen and his colleagues have been amassing a genetic database complete with siblings with rheumatoid arthritis (and some family members without it) in an attempt to single out those genes that are involved in the autoimmune process. (
  • In fact, in 2004, they identified a gene called PTPN2 that confers a two-fold risk for rheumatoid arthritis and a number of other autoimmune diseases. (
  • In autoimmune diseases like rheumatoid arthritis, PTPN22 appears to put people at higher risk of a wayward T-cell response. (


  • Food might not be the first thing on your mind when you have the stiffness, swelling, and pain of rheumatoid arthritis (RA). (
  • Rheumatoid Arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. (

immune system

  • Next, the cells were stimulated with a protein of the immune system known to play a role in causing joint degradation in rheumatoid arthritis. (
  • This immune system antibody associated with rheumatoid arthritis recognizes citrulline, which seems to be a key player in the condition. (


  • Rheumatoid factor (RF) is an antibody found in about 80 percent of people with RA during the course of their disease. (


  • He slipped each peptide into a "ghostlike" molecule that he injected into mice with a rheumatoid arthritis-like disease. (
  • The group has discovered another signaling molecule that seems to increase a person's risk for rheumatoid arthritis by 30 percentIn collaborations with other scientists worldwide, Dr. Gregersen has also been able to show that certain markers are strongly linked to certain ethnic groups and others are not. (


  • Existing treatments for rheumatoid arthritis include low-level chemotherapy and steroids. (
  • According to the Mayo Clinic , common treatments for rheumatoid arthritis also include physical therapy, steroids and even joint replacement or other types of surgery. (
  • There are various medications and treatments that can make living with rheumatoid arthritis easier, but I've found it was necessary to change many of my daily activities to cope with this condition. (


  • When the scientists developed and injected an imitation of the protein into an animal model of rheumatoid arthritis, the disease process was halted. (


  • The type of presentation you have said, points towards the diagnosis of Degenerative arthritis.Chondrosulf 400mg is the right medicine for the arthritis.But i think, you would need to start spine physiotherapy also along with the medicines as arthritis causes pain.The present medication will only de-accelerate the speed of arthritis. (


  • Those proteins and enzymes can infiltrate the joints and cause the cartilage breakdown seen in people with rheumatoid arthritis. (
  • People have long feared rheumatoid arthritis (commonly called RA) as one of the most disabling types of arthritis. (
  • CHICAGO -- Researchers at Northwestern University Feinberg School of Medicine have discovered why the immune cells of people with rheumatoid arthritis become hyperactive and attack the joints and bones. (
  • Previous research by the Feinberg team showed people with rheumatoid arthritis were low in P21, but the protein's role was unknown. (
  • Developments in rheumatoid arthritis reported at Federation of Clinical Immunology Services meeting in San Diego to figure out what makes these people susceptible to the disabling inflammatory condition. (
  • I always assumed that arthritis was something that happened to people as they grew older. (

clinical trials

  • In a news release, UCB states that the FDA approved Cimzia to treat rheumatoid arthritis based on clinical trials in which more than 2,300 rheumatoid arthritis patients taking Cimzia with another drug, methotrexate, had a greater reduction in signs and symptoms of RA after 24 weeks of treatment, compared to patients only taking methotrexate. (


  • Symptoms of rheumatoid arthritis (RA) don't stop at joint pain and swelling. (
  • At first, these medications helped to reduce my symptoms, and living with rheumatoid arthritis was not very difficult. (


  • For the study, Ahmed isolated cells called synovial fibroblasts from the joints of patients with rheumatoid arthritis. (


  • He has put me on Condrosulf 400mg - are these tablets given to help any type of arthritis or are they prescribed to help a particilar form of arthritis. (


  • Worse, rheumatoid arthritis is a mostly silent and invisible condition. (

types of arthritis

  • According to the Mayo Clinic , different types of arthritis can actually strike at any age and occur in any joint. (


  • About 2.1 million Americans have rheumatoid arthritis, according to the Arthritis Foundation. (


  • In patients with rheumatoid arthritis, this lining is inflamed, leading to long-term joint damage and chronic pain. (
  • If it bears out, it could be good news for rheumatoid arthritis patients, perhaps offering them a non-drug option to keep pain under control, he said. (
  • Ahmed cautioned that it's too soon to advise rheumatoid arthritis patients to drink green tea. (
  • Dr. Gregersen has finally closed the circle between key genes identified in his laboratory at the Robert S. Boas Center for Genomics and Human Genetics at The Feinstein Institute for Medical Research in Manhasset, NY and more than a 1,000 patients with rheumatoid arthritis. (
  • The Feinstein now holds the largest collection from rheumatoid arthritis patients in the world. (
  • The purpose of the community is to share support and information with Rheumatoid Arthritis (RA) patients and their loved ones. (
  • Can treatment of rheumatoid arthritis with IL-1 blockade also improve metabolic status in patients with associated Type 2 diabetes? (


  • This discovery opens up a new avenue for future therapies, which are greatly needed for rheumatoid arthritis. (


  • The new research by Ahmed is one of the first to focus on rheumatoid arthritis and green tea, Hsu said. (
  • Early on in the rheumatoid arthritis research game, when HLA popped out as a major genetic player in the condition in the 1980s, Dr. Gregersen discovered that there was a shared bit of DNA that traveled in the disease. (
  • A high BMI in men and the type of fat men develop could be reducing their risk of getting rheumatoid arthritis, according to new research from Sweden. (



  • Whole grains contain levels of fiber, antioxidants, vitamins, and minerals not found in refined versions that make them more beneficial for those with arthritis ," Sandon says. (
  • All of these strategies make living with rheumatoid arthritis a bit easier. (


  • Washington, Sept 25 (ANI): Its not just smoking and alcohol that are instrumental in increasing the risk of rheumatoid arthritis, working environment too plays a critical role, say researchers. (


  • It's too early" to fully recommend green tea to ease rheumatoid arthritis, he said, but the study "is a starting point. (
  • The new study, which will be published in the journal Arthritis & Rheumatism , reveals the protein's vital role in keeping the immune cells in check. (


  • India's patent office has again rejected US drug major Pfizer's new patent application for its rheumatoid arthritis medicine, tofacitinib, citing it did not enhance the efficacy of the existing approved drug. (


  • About 10 years ago I was diagnosed with Lumbar Spondylosis and more recently, after xrays etc on my neck and shoulders, my GP has told me I have arthritis in these areas. (


  • She has been suffering with rheumatoid Arthritus for long. (


  • In its early stages, RA may resemble other forms of inflammatory arthritis. (


  • Dear Sallybeans, When you are asking ' Type of Arthritis' are you specifically asking to rule out RA? (


  • Scientists at Karolinska Institutet have revealed that working environment factors can also increase the odds of developing rheumatoid arthritis. (


  • To learn more about rheumatoid arthritis, visit the Arthritis Foundation . (


  • I am 23 and i live with Ankylosing Spondylitis & Rheumatoid Arthritis. (


  • India has reportedly rejected US drug-maker Pfizer's new patent application for rheumatoid arthritis drug, tofacitinib, for the second time. (