Viruses whose hosts are in the domain ARCHAEA.
A genus of facultatively anaerobic coccoid ARCHAEA, in the family SULFOLOBACEAE. Cells are highly irregular in shape and thermoacidophilic. Lithotrophic growth occurs aerobically via sulfur oxidation in some species. Distribution includes solfataric springs and fields, mudholes, and geothermically heated acidic marine environments.
A genus of aerobic, chemolithotrophic, coccoid ARCHAEA whose organisms are thermoacidophilic. Its cells are highly irregular in shape, often lobed, but occasionally spherical. It has worldwide distribution with organisms isolated from hot acidic soils and water. Sulfur is used as an energy source.
Family of rod-shaped DNA viruses infecting ARCHAEA. They lack viral envelopes or lipids.
A family of lemon-shaped DNA viruses infecting ARCHAEA and containing one genus: Fusellovirus.
Family of enveloped, lipid-containing, filamentous DNA viruses that infect ARCHAEA.
Proteins found in any species of archaeon.
A genus of HALOBACTERIACEAE distinguished from other genera in the family by the presence of specific derivatives of TGD-2 polar lipids. Haloarcula are found in neutral saline environments such as salt lakes, marine salterns, and saline soils.
A genus of HALOBACTERIACEAE which are chemoorganotrophic and strictly aerobic. They have been isolated from multiple hypersaline environments that vary widely in chemical and physical properties.
One of the three domains of life (the others being BACTERIA and Eukarya), formerly called Archaebacteria under the taxon Bacteria, but now considered separate and distinct. They are characterized by: (1) the presence of characteristic tRNAs and ribosomal RNAs; (2) the absence of peptidoglycan cell walls; (3) the presence of ether-linked lipids built from branched-chain subunits; and (4) their occurrence in unusual habitats. While archaea resemble bacteria in morphology and genomic organization, they resemble eukarya in their method of genomic replication. The domain contains at least four kingdoms: CRENARCHAEOTA; EURYARCHAEOTA; NANOARCHAEOTA; and KORARCHAEOTA.
Ribonucleic acid in archaea having regulatory and catalytic roles as well as involvement in protein synthesis.
Viruses whose nucleic acid is DNA.
Deoxyribonucleic acid that makes up the genetic material of archaea.
The functional genetic units of ARCHAEA.
The genetic complement of an archaeal organism (ARCHAEA) as represented in its DNA.
Habitat of hot water naturally heated by underlying geologic processes. Surface hot springs have been used for BALNEOLOGY. Underwater hot springs are called HYDROTHERMAL VENTS.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Proteins found in any species of virus.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Viruses whose genetic material is RNA.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in archaea.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Process of growing viruses in live animals, plants, or cultured cells.
The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
The relationships of groups of organisms as reflected by their genetic makeup.
A family of anaerobic, coccoid to rod-shaped METHANOBACTERIALES. Cell membranes are composed mainly of polyisoprenoid hydrocarbons ether-linked to glycerol. Its organisms are found in anaerobic habitats throughout nature.
An order of anaerobic methanogens in the kingdom EURYARCHAEOTA. They are pseudosarcina, coccoid or sheathed rod-shaped and catabolize methyl groups. The cell wall is composed of protein. The order includes one family, METHANOCOCCACEAE. (From Bergey's Manual of Systemic Bacteriology, 1989)
A general term for diseases produced by viruses.
A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
A kingdom in the domain ARCHAEA comprised of thermoacidophilic, sulfur-dependent organisms. The two orders are SULFOLOBALES and THERMOPROTEALES.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
Viruses parasitic on plants higher than bacteria.
Structures within the nucleus of archaeal cells consisting of or containing DNA, which carry genetic information essential to the cell.
I'm sorry for any confusion, but "Kentucky" is a proper noun and not a term that has a medical definition. It is a state located in the eastern region of the United States. If you have any questions related to medical conditions or terminology, I would be happy to help answer those!
A collective genome representative of the many organisms, primarily microorganisms, existing in a community.
The full collection of microbes (bacteria, fungi, virus, etc.) that naturally exist within a particular biological niche such as an organism, soil, a body of water, etc.
Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).
Short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.
A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.
Derivatives of BUTYRIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxypropane structure.

Viruses from extreme thermal environments. (1/74)

Viruses of extreme thermophiles are of great interest because they serve as model systems for understanding the biochemistry and molecular biology required for life at high temperatures. In this work, we report the discovery, isolation, and preliminary characterization of viruses and virus-like particles from extreme thermal acidic environments (70-92 degrees C, pH 1.0-4.5) found in Yellowstone National Park. Six unique particle morphologies were found in Sulfolobus enrichment cultures. Three of the particle morphologies are similar to viruses previously isolated from Sulfolobus species from Iceland and/or Japan. Sequence analysis of their viral genomes suggests that they are related to the Icelandic and Japanese isolates. In addition, three virus particle morphologies that had not been previously observed from thermal environments were found. These viruses appear to be completely novel in nature.  (+info)

Comparative genomic analysis of hyperthermophilic archaeal Fuselloviridae viruses. (2/74)

The complete genome sequences of two Sulfolobus spindle-shaped viruses (SSVs) from acidic hot springs in Kamchatka (Russia) and Yellowstone National Park (United States) have been determined. These nonlytic temperate viruses were isolated from hyperthermophilic Sulfolobus hosts, and both viruses share the spindle-shaped morphology characteristic of the Fuselloviridae family. These two genomes, in combination with the previously determined SSV1 genome from Japan and the SSV2 genome from Iceland, have allowed us to carry out a phylogenetic comparison of these geographically distributed hyperthermal viruses. Each virus contains a circular double-stranded DNA genome of approximately 15 kbp with approximately 34 open reading frames (ORFs). These Fusellovirus ORFs show little or no similarity to genes in the public databases. In contrast, 18 ORFs are common to all four isolates and may represent the minimal gene set defining this viral group. In general, ORFs on one half of the genome are colinear and highly conserved, while ORFs on the other half are not. One shared ORF among all four genomes is an integrase of the tyrosine recombinase family. All four viral genomes integrate into their host tRNA genes. The specific tRNA gene used for integration varies, and one genome integrates into multiple loci. Several unique ORFs are found in the genome of each isolate.  (+info)

Haloviruses HF1 and HF2: evidence for a recent and large recombination event. (3/74)

Haloviruses HF1 and HF2 were isolated from the same saltern pond and are adapted to hypersaline conditions, where they infect a broad range of haloarchaeal species. The HF2 genome has previously been reported. The complete sequence of the HF1 genome has now been determined, mainly by PCR and primer walking. It was 75,898 bp in length and was 94.4% identical to the HF2 genome but about 1.8 kb shorter. A total of 117 open reading frames and five tRNA-like genes were predicted, and their database matches and characteristics were similar to those found in HF2. A comparison of the predicted restriction digest patterns based on nucleotide sequence with the observed restriction digest patterns of viral DNA showed that, unlike the case for HF2, some packaged HF1 DNA had cohesive termini. Except for a single base change, HF1 and HF2 were identical in sequence over the first 48 kb, a region that includes the early and middle genes. The remaining 28 kb of HF1 showed many differences from HF2, and the similarity of the two genomes over this late gene region was 87%. The abrupt shift in sequence similarity around 48 kb suggests a recent recombination event between either HF1 or HF2 and another HF-like halovirus that has swapped most of the right-end 28 kb. This example indicates there is a high level of recombination among viruses that live in this extreme environment.  (+info)

Morphology and genome organization of the virus PSV of the hyperthermophilic archaeal genera Pyrobaculum and Thermoproteus: a novel virus family, the Globuloviridae. (4/74)

A novel virus, termed Pyrobaculum spherical virus (PSV), is described that infects anaerobic hyperthermophilic archaea of the genera Pyrobaculum and Thermoproteus. Spherical enveloped virions, about 100 nm in diameter, contain a major multimeric 33-kDa protein and host-derived lipids. A viral envelope encases a superhelical nucleoprotein core containing linear double-stranded DNA. The PSV infection cycle does not cause lysis of host cells. The viral genome was sequenced and contains 28337 bp. The genome is unique for known archaeal viruses in that none of the genes, including that encoding the major structural protein, show any significant sequence matches to genes in public sequence databases. Exceptionally for an archaeal double-stranded DNA virus, almost all the recognizable genes are located on one DNA strand. The ends of the genome consist of 190-bp inverted repeats that contain multiple copies of short direct repeats. The two DNA strands are probably covalently linked at their termini. On the basis of the unusual morphological and genomic properties of this DNA virus, we propose to assign PSV to a new viral family, the Globuloviridae.  (+info)

SH1: A novel, spherical halovirus isolated from an Australian hypersaline lake. (5/74)

A novel halovirus, SH1, with a spherical morphology is described. Isolated from a hypersaline lake, SH1 is divalent, producing clear plaques on Haloarcula hispanica and a natural Halorubrum isolate. Single-step growth curves gave a latent period of 5-6 h and a burst size of around 200 PFU/cell. The host can differentiate to form tight clusters of thick cell-walled forms, and these were shown to be resistant to infection. Purified virions had no visible tail, were about 70 nm in diameter, and displayed a fragile outer capsid layer, possibly with an underlying membrane component. The structural proteins of the virion were analyzed by SDS-PAGE and several were found to be cross-linked, forming protein complexes. The genome was linear, dsDNA, of approximately 30 kb in length. This morphology and linear genome are features not observed in any other euryarchaeal viruses, but have properties similar to the bacterial virus PRD1.  (+info)

Sulfolobus tengchongensis spindle-shaped virus STSV1: virus-host interactions and genomic features. (6/74)

A virus infecting the hyperthermophilic archaeon Sulfolobus tengchongensis has been isolated from a field sample from Tengchong, China, and characterized. The virus, denoted STSV1 (Sulfolobus tengchongensis spindle-shaped virus 1), has the morphology of a spindle (230 by 107 nm) with a tail of variable length (68 nm on average) at one end and is the largest of the known spindle-shaped viruses. After infecting its host, the virus multiplied rapidly to high titers (>10(10) PFU/ml). Replication of the virus retarded host growth but did not cause lysis of the host cells. STSV1 did not integrate into the host chromosome and existed in a carrier state. The STSV1 DNA was modified in an unusual fashion, presumably by virally encoded modification systems. STSV1 harbors a double-stranded DNA genome of 75,294 bp, which shares no significant sequence similarity to those of fuselloviruses. The viral genome contains a total of 74 open reading frames (ORFs), among which 14 have a putative function. Five ORFs encode viral structural proteins, including a putative coat protein of high abundance. The products of the other nine ORFs are probably involved in polysaccharide biosynthesis, nucleotide metabolism, and DNA modification. The viral genome divides into two nearly equal halves of opposite gene orientation. This observation as well as a GC-skew analysis point to the presence of a putative viral origin of replication in the 1.4-kb intergenic region between ORF1 and ORF74. Both morphological and genomic features identify STSV1 as a novel virus infecting the genus Sulfolobus.  (+info)

Purification, crystallization and preliminary X-ray diffraction studies of the archaeal virus resolvase SIRV2. (7/74)

The Holliday junction (or four-way junction) is the universal DNA intermediate whose interaction with resolving proteins is one of the major events in the recombinational process. These proteins, called DNA junction-resolving enzymes or resolvases, bind to the junction and catalyse DNA cleavage, promoting the release of two DNA duplexes. SIRV2 Hjc, a viral resolvase infecting a thermophylic archaeon, has been cloned, expressed and purified. Crystals have been obtained in space group C2, with unit-cell parameters a = 147.8, b = 99.9, c = 87.6, beta = 109.46 degrees, and a full data set has been collected at 3.4 A resolution. The self-rotation function indicates the presence of two dimers in the asymmetric unit and a high solvent content (77%). Molecular-replacement trials using known similar resolvase structures have so far been unsuccessful, indicating possible significant structural rearrangements.  (+info)

Characterization of the archaeal thermophile Sulfolobus turreted icosahedral virus validates an evolutionary link among double-stranded DNA viruses from all domains of life. (8/74)

Icosahedral nontailed double-stranded DNA (dsDNA) viruses are present in all three domains of life, leading to speculation about a common viral ancestor that predates the divergence of Eukarya, Bacteria, and Archaea. This suggestion is supported by the shared general architecture of this group of viruses and the common fold of their major capsid protein. However, limited information on the diversity and replication of archaeal viruses, in general, has hampered further analysis. Sulfolobus turreted icosahedral virus (STIV), isolated from a hot spring in Yellowstone National Park, was the first icosahedral virus with an archaeal host to be described. Here we present a detailed characterization of the components forming this unusual virus. Using a proteomics-based approach, we identified nine viral and two host proteins from purified STIV particles. Interestingly, one of the viral proteins originates from a reading frame lacking a consensus start site. The major capsid protein (B345) was found to be glycosylated, implying a strong similarity to proteins from other dsDNA viruses. Sequence analysis and structural predication of virion-associated viral proteins suggest that they may have roles in DNA packaging, penton formation, and protein-protein interaction. The presence of an internal lipid layer containing acidic tetraether lipids has also been confirmed. The previously presented structural models in conjunction with the protein, lipid, and carbohydrate information reported here reveal that STIV is strikingly similar to viruses associated with the Bacteria and Eukarya domains of life, further strengthening the hypothesis for a common ancestor of this group of dsDNA viruses from all domains of life.  (+info)

Archaeal viruses are viruses that infect and replicate within archaea, which are single-celled microorganisms without a nucleus. These viruses have unique characteristics that distinguish them from bacterial and eukaryotic viruses. They often possess distinct morphologies, such as icosahedral or filamentous shapes, and their genomes can be composed of double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), double-stranded RNA (dsRNA), or single-stranded RNA (ssRNA).

Archaeal viruses have evolved various strategies to hijack the host cell's machinery for replication, packaging, and release of new virus particles. Some archaeal viruses even encode their own proteins for transcription and translation, suggesting a more complex relationship with their hosts than previously thought. The study of archaeal viruses provides valuable insights into the evolution of viruses and their hosts and has implications for understanding the origins of life on Earth.

'Acidianus' is a genus of thermoacidophilic archaea, which are extremophiles that thrive in extremely acidic and hot environments. These microorganisms are commonly found in volcanic areas, such as sulfur-rich hot springs and deep-sea hydrothermal vents, where the pH levels can be as low as 0 and the temperature can reach up to 90°C (194°F).

The name 'Acidianus' is derived from the Latin word "acidus," meaning sour or acidic, and the Greek word "ianos," meaning belonging to. Therefore, the medical definition of 'Acidianus' refers to a genus of archaea that are adapted to survive in highly acidic environments.

These microorganisms have developed unique metabolic pathways to generate energy from sulfur compounds and other reduced substances present in their environment. They play an essential role in the global carbon and sulfur cycles, contributing to the breakdown of organic matter and the formation of elemental sulfur and sulfate.

Understanding the biology and ecology of 'Acidianus' and other thermoacidophilic archaea can provide insights into the limits of life on Earth and help us explore the potential for extraterrestrial life in extreme environments, such as those found on Mars or other planets.

"Sulfolobus" is a genus of archaea, which are single-celled microorganisms that share characteristics with both bacteria and eukaryotes. These archaea are extremophiles, meaning they thrive in extreme environments that are hostile to most other life forms. Specifically, Sulfolobus species are acidothermophiles, capable of growing at temperatures between 75-85°C and pH levels near 3. They are commonly found in volcanic hot springs and other acidic, high-temperature environments. The cells of Sulfolobus are typically irregular in shape and have a unique system for replicating their DNA. Some species are capable of oxidizing sulfur compounds as a source of energy.

Rudiviridae is a family of double-stranded, rigid rod-shaped viruses that infect archaea. These viruses have linear genomes and typically measure between 400-700 nanometers in length. They are characterized by their unique tail fibers, which they use to attach to and infect their host cells. Rudiviridae viruses primarily infect hyperthermophilic archaea that live in extreme environments, such as hot springs and deep-sea hydrothermal vents. Due to the limited number of studies on these viruses and their hosts, much is still unknown about their biology and ecological significance.

Fuselloviridae is a family of viruses that infect archaea, particularly members of the order Thermoproteales within the domain Archaea. These viruses are characterized by their unique, lemon-shaped or spindle-shaped (fusiform) morphology and a linear, double-stranded DNA genome with covalently closed hairpin ends. The family Fuselloviridae is part of the order Ligamenvirales, which also includes other archaeal virus families like Lipothrixviridae and Rudiviridae.

Fuselloviruses are known to infect hyperthermophilic archaea, such as Sulfolobus species, living in extreme environments with high temperatures (70-105°C) and low pH values (2-4). The most well-studied member of this family is the Sulfolobus turreted icosahedral virus (STIV), which has a complex virion structure consisting of an icosahedral capsid with protruding turrets at the vertices.

Fuselloviruses have been found to play a role in the horizontal gene transfer among archaea, as they can carry and integrate foreign genes into their host's genome during infection. This ability contributes to the genetic diversity and evolution of archaeal communities in extreme environments.

Lipothrixviridae is a family of enveloped, rod-shaped viruses that infect archaea. These viruses have a unique lipid membrane derived from the host cell and a linear, double-stranded DNA genome. The virions are typically long and thin, with a hollow core and helical symmetry. Lipothrixviridae is named after its characteristic lipid membrane and rigid structure.

The family Lipothrixviridae includes only one genus, Thermopolisibacteriovirus, which contains several species of viruses that infect thermophilic archaea in the order Crenarchaeota. The prototypical member of this family is the virus SIRV2 (Sulfolobus islandicus rod-shaped virus 2).

Lipothrixviridae viruses have a complex life cycle, involving attachment to the host cell surface, membrane fusion, and injection of the viral genome into the host cytoplasm. The viral DNA is then replicated using the host's replication machinery, and new virions are assembled in the host cell before being released by lysis or extrusion.

Infection with Lipothrixviridae viruses can have significant impacts on the host archaea, including alterations to their metabolism, growth rate, and morphology. However, the precise mechanisms of these effects are not well understood and require further study.

Archaeal proteins are proteins that are encoded by the genes found in archaea, a domain of single-celled microorganisms. These proteins are crucial for various cellular functions and structures in archaea, which are adapted to survive in extreme environments such as high temperatures, high salt concentrations, and low pH levels.

Archaeal proteins share similarities with both bacterial and eukaryotic proteins, but they also have unique features that distinguish them from each other. For example, many archaeal proteins contain unusual amino acids or modifications that are not commonly found in other organisms. Additionally, the three-dimensional structures of some archaeal proteins are distinct from their bacterial and eukaryotic counterparts.

Studying archaeal proteins is important for understanding the biology of these unique organisms and for gaining insights into the evolution of life on Earth. Furthermore, because some archaea can survive in extreme environments, their proteins may have properties that make them useful in industrial and medical applications.

"Haloarcula" is a genus of archaea, which are single-celled microorganisms that lack a nucleus and other membrane-bound organelles. This genus belongs to the family Halobacteriaceae and is characterized by its ability to thrive in extremely salty environments, such as salt lakes and salt mines. The cells of Haloarcula species are typically pink or red due to the presence of carotenoid pigments, which help protect the organisms from high levels of solar radiation.

Haloarcula species are heterotrophic, meaning they obtain energy by consuming organic matter. They are also aerobic, requiring oxygen to grow and metabolize nutrients. Like other members of the domain Archaea, Haloarcula species have a unique cell wall structure and genetic material that is distinct from bacteria and eukaryotes.

It's important to note that "Haloarcula" is a medical definition in the sense that it refers to a specific genus of archaea that can have implications for human health, particularly in the context of environmental health and microbial ecology. However, Haloarcula species are not typically associated with human diseases or infections.

"Halorubrum" is a genus of archaea, which are single-celled microorganisms that lack a nucleus and other membrane-bound organelles. Halorubrum species are extremely halophilic, meaning they require a high salt concentration to grow. They are typically found in hypersaline environments such as salt lakes, salt pans, and solar salterns. The cells of Halorubrum species are usually pink or red due to the presence of carotenoid pigments that protect them from UV radiation.

The name "Halorubrum" is derived from the Greek words "halos," meaning salt, and "ruber," meaning red. Therefore, a medical definition of 'Halorubrum' would be:

A genus of archaea belonging to the family Halobacteriaceae, characterized by their extreme halophilic nature and pink or red-colored cells due to the presence of carotenoid pigments. They are typically found in hypersaline environments and can cause infections in humans under certain circumstances, although they are not considered part of the normal human microbiota.

Archaea are a domain of single-celled microorganisms that lack membrane-bound nuclei and other organelles. They are characterized by the unique structure of their cell walls, membranes, and ribosomes. Archaea were originally classified as bacteria, but they differ from bacteria in several key ways, including their genetic material and metabolic processes.

Archaea can be found in a wide range of environments, including some of the most extreme habitats on Earth, such as hot springs, deep-sea vents, and highly saline lakes. Some species of Archaea are able to survive in the absence of oxygen, while others require oxygen to live.

Archaea play important roles in global nutrient cycles, including the nitrogen cycle and the carbon cycle. They are also being studied for their potential role in industrial processes, such as the production of biofuels and the treatment of wastewater.

Archaeal RNA refers to the Ribonucleic acid (RNA) molecules that are present in archaea, which are a domain of single-celled microorganisms. RNA is a nucleic acid that plays a crucial role in various biological processes, such as protein synthesis, gene expression, and regulation of cellular activities.

Archaeal RNAs can be categorized into different types based on their functions, including:

1. Messenger RNA (mRNA): It carries genetic information from DNA to the ribosome, where it is translated into proteins.
2. Transfer RNA (tRNA): It helps in translating the genetic code present in mRNA into specific amino acids during protein synthesis.
3. Ribosomal RNA (rRNA): It is a structural and functional component of ribosomes, where protein synthesis occurs.
4. Non-coding RNA: These are RNAs that do not code for proteins but have regulatory functions in gene expression and other cellular processes.

Archaeal RNAs share similarities with both bacterial and eukaryotic RNAs, but they also possess unique features that distinguish them from the other two domains of life. For example, archaeal rRNAs contain unique sequence motifs and secondary structures that are not found in bacteria or eukaryotes. These differences suggest that archaeal RNAs have evolved to adapt to the extreme environments where many archaea live.

Overall, understanding the structure, function, and evolution of archaeal RNA is essential for gaining insights into the biology of these unique microorganisms and their roles in various cellular processes.

DNA viruses are a type of virus that contain DNA (deoxyribonucleic acid) as their genetic material. These viruses replicate by using the host cell's machinery to synthesize new viral components, which are then assembled into new viruses and released from the host cell.

DNA viruses can be further classified based on the structure of their genomes and the way they replicate. For example, double-stranded DNA (dsDNA) viruses have a genome made up of two strands of DNA, while single-stranded DNA (ssDNA) viruses have a genome made up of a single strand of DNA.

Examples of DNA viruses include herpes simplex virus, varicella-zoster virus, human papillomavirus, and adenoviruses. Some DNA viruses are associated with specific diseases, such as cancer (e.g., human papillomavirus) or neurological disorders (e.g., herpes simplex virus).

It's important to note that while DNA viruses contain DNA as their genetic material, RNA viruses contain RNA (ribonucleic acid) as their genetic material. Both DNA and RNA viruses can cause a wide range of diseases in humans, animals, and plants.

Archaeal DNA refers to the genetic material present in archaea, a domain of single-celled microorganisms lacking a nucleus. Like bacteria, archaea have a single circular chromosome that contains their genetic information. However, archaeal DNA is significantly different from bacterial and eukaryotic DNA in terms of its structure and composition.

Archaeal DNA is characterized by the presence of unique modifications such as methylation patterns, which help distinguish it from other types of DNA. Additionally, archaea have a distinct set of genes involved in DNA replication, repair, and recombination, many of which are more similar to those found in eukaryotes than bacteria.

One notable feature of archaeal DNA is its resistance to environmental stressors such as extreme temperatures, pH levels, and salt concentrations. This allows archaea to thrive in some of the most inhospitable environments on Earth, including hydrothermal vents, acidic hot springs, and highly saline lakes.

Overall, the study of archaeal DNA has provided valuable insights into the evolutionary history of life on Earth and the unique adaptations that allow these organisms to survive in extreme conditions.

I'm happy to help! However, I believe there might be a slight mistake in your question. "Archaeal" is not a term used to describe genes but rather a group of single-celled organisms that are classified as archaea.

Archaea are one of the three domains of life, along with bacteria and eukaryotes (which include plants, animals, and fungi). Archaea are unique because they share characteristics with both bacteria and eukaryotes, but they also have many features that are distinctly their own. For example, archaea have a different cell membrane structure than bacteria and eukaryotes, which allows them to thrive in extreme environments such as hot springs, salt mines, and deep-sea vents.

Genes, on the other hand, are segments of DNA that contain the instructions for making proteins or performing other important functions in an organism's cells. All living organisms, including archaea, have genes that are passed down from generation to generation. Archaeal genes are made up of the same four nucleotides (A, T, C, and G) as bacterial and eukaryotic genes, and they code for proteins and RNA molecules that are essential for the survival and reproduction of archaea.

So, to summarize, there is no specific definition for "Archaeal genes" because "archaeal" is not a term used to describe genes. However, we can say that archaeal genes are segments of DNA that contain the instructions for making proteins and performing other important functions in archaea.

An archaeal genome refers to the complete set of genetic material or DNA present in an archaea, a single-celled microorganism that is found in some of the most extreme environments on Earth. The genome of an archaea contains all the information necessary for its survival, including the instructions for building proteins and other essential molecules, as well as the regulatory elements that control gene expression.

Archaeal genomes are typically circular in structure and range in size from about 0.5 to over 5 million base pairs. They contain genes that are similar to those found in bacteria and eukaryotes, as well as unique genes that are specific to archaea. The study of archaeal genomes has provided valuable insights into the evolutionary history of life on Earth and has helped scientists understand the adaptations that allow these organisms to thrive in such harsh environments.

'Hot Springs' are a type of geothermal feature where water is heated by the Earth's internal heat and emerges from the ground at temperatures greater than the surrounding air temperature. The water in hot springs can range in temperature from warm to extremely hot, and it is often rich in minerals such as calcium, magnesium, sulfur, and sodium.

People have been using hot springs for thousands of years for various purposes, including relaxation, recreation, and therapeutic benefits. The heat and mineral content of the water can help to soothe sore muscles, improve circulation, and promote healing in some cases. However, it is important to note that not all hot springs are safe for bathing, as some may contain harmful bacteria or pollutants. It is always recommended to check with local authorities before using a hot spring for therapeutic purposes.

A viral genome is the genetic material (DNA or RNA) that is present in a virus. It contains all the genetic information that a virus needs to replicate itself and infect its host. The size and complexity of viral genomes can vary greatly, ranging from a few thousand bases to hundreds of thousands of bases. Some viruses have linear genomes, while others have circular genomes. The genome of a virus also contains the information necessary for the virus to hijack the host cell's machinery and use it to produce new copies of the virus. Understanding the genetic makeup of viruses is important for developing vaccines and antiviral treatments.

A virion is the complete, infectious form of a virus outside its host cell. It consists of the viral genome (DNA or RNA) enclosed within a protein coat called the capsid, which is often surrounded by a lipid membrane called the envelope. The envelope may contain viral proteins and glycoproteins that aid in attachment to and entry into host cells during infection. The term "virion" emphasizes the infectious nature of the virus particle, as opposed to non-infectious components like individual capsid proteins or naked viral genome.

Viral proteins are the proteins that are encoded by the viral genome and are essential for the viral life cycle. These proteins can be structural or non-structural and play various roles in the virus's replication, infection, and assembly process. Structural proteins make up the physical structure of the virus, including the capsid (the protein shell that surrounds the viral genome) and any envelope proteins (that may be present on enveloped viruses). Non-structural proteins are involved in the replication of the viral genome and modulation of the host cell environment to favor viral replication. Overall, a thorough understanding of viral proteins is crucial for developing antiviral therapies and vaccines.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

RNA viruses are a type of virus that contain ribonucleic acid (RNA) as their genetic material, as opposed to deoxyribonucleic acid (DNA). RNA viruses replicate by using an enzyme called RNA-dependent RNA polymerase to transcribe and replicate their RNA genome.

There are several different groups of RNA viruses, including:

1. Negative-sense single-stranded RNA viruses: These viruses have a genome that is complementary to the mRNA and must undergo transcription to produce mRNA before translation can occur. Examples include influenza virus, measles virus, and rabies virus.
2. Positive-sense single-stranded RNA viruses: These viruses have a genome that can serve as mRNA and can be directly translated into protein after entry into the host cell. Examples include poliovirus, rhinoviruses, and coronaviruses.
3. Double-stranded RNA viruses: These viruses have a genome consisting of double-stranded RNA and use a complex replication strategy involving both transcription and reverse transcription. Examples include rotaviruses and reoviruses.

RNA viruses are known to cause a wide range of human diseases, ranging from the common cold to more severe illnesses such as hepatitis C, polio, and COVID-19. Due to their high mutation rates and ability to adapt quickly to new environments, RNA viruses can be difficult to control and treat with antiviral drugs or vaccines.

Gene expression regulation in archaea refers to the complex cellular processes that control the transcription and translation of genes into functional proteins. This regulation is crucial for the survival and adaptation of archaea to various environmental conditions.

Archaea, like bacteria and eukaryotes, use a variety of mechanisms to regulate gene expression, including:

1. Transcriptional regulation: This involves controlling the initiation, elongation, and termination of transcription by RNA polymerase. Archaea have a unique transcription machinery that is more similar to eukaryotic RNA polymerases than bacterial ones. Transcriptional regulators, such as activators and repressors, bind to specific DNA sequences near the promoter region to modulate transcription.
2. Post-transcriptional regulation: This includes processes like RNA processing, modification, and degradation that affect mRNA stability and translation efficiency. Archaea have a variety of RNA-binding proteins and small non-coding RNAs (sRNAs) that play crucial roles in post-transcriptional regulation.
3. Translational regulation: This involves controlling the initiation, elongation, and termination of translation by ribosomes. Archaea use a unique set of translation initiation factors and tRNA modifications to regulate protein synthesis.
4. Post-translational regulation: This includes processes like protein folding, modification, and degradation that affect protein stability and function. Archaea have various chaperones, proteases, and modifying enzymes that participate in post-translational regulation.

Overall, gene expression regulation in archaea is a highly dynamic and coordinated process involving multiple layers of control to ensure proper gene expression under changing environmental conditions.

Vaccinia virus is a large, complex DNA virus that belongs to the Poxviridae family. It is the virus used in the production of the smallpox vaccine. The vaccinia virus is not identical to the variola virus, which causes smallpox, but it is closely related and provides cross-protection against smallpox infection.

The vaccinia virus has a unique replication cycle that occurs entirely in the cytoplasm of infected cells, rather than in the nucleus like many other DNA viruses. This allows the virus to evade host cell defenses and efficiently produce new virions. The virus causes the formation of pocks or lesions on the skin, which contain large numbers of virus particles that can be transmitted to others through close contact.

Vaccinia virus has also been used as a vector for the delivery of genes encoding therapeutic proteins, vaccines against other infectious diseases, and cancer therapies. However, the use of vaccinia virus as a vector is limited by its potential to cause adverse reactions in some individuals, particularly those with weakened immune systems or certain skin conditions.

Virus receptors are specific molecules (commonly proteins) on the surface of host cells that viruses bind to in order to enter and infect those cells. This interaction between the virus and its receptor is a critical step in the infection process. Different types of viruses have different receptor requirements, and identifying these receptors can provide important insights into the biology of the virus and potential targets for antiviral therapies.

Virus replication is the process by which a virus produces copies or reproduces itself inside a host cell. This involves several steps:

1. Attachment: The virus attaches to a specific receptor on the surface of the host cell.
2. Penetration: The viral genetic material enters the host cell, either by invagination of the cell membrane or endocytosis.
3. Uncoating: The viral genetic material is released from its protective coat (capsid) inside the host cell.
4. Replication: The viral genetic material uses the host cell's machinery to produce new viral components, such as proteins and nucleic acids.
5. Assembly: The newly synthesized viral components are assembled into new virus particles.
6. Release: The newly formed viruses are released from the host cell, often through lysis (breaking) of the cell membrane or by budding off the cell membrane.

The specific mechanisms and details of virus replication can vary depending on the type of virus. Some viruses, such as DNA viruses, use the host cell's DNA polymerase to replicate their genetic material, while others, such as RNA viruses, use their own RNA-dependent RNA polymerase or reverse transcriptase enzymes. Understanding the process of virus replication is important for developing antiviral therapies and vaccines.

Virus cultivation, also known as virus isolation or viral culture, is a laboratory method used to propagate and detect viruses by introducing them to host cells and allowing them to replicate. This process helps in identifying the specific virus causing an infection and studying its characteristics, such as morphology, growth pattern, and sensitivity to antiviral agents.

The steps involved in virus cultivation typically include:

1. Collection of a clinical sample (e.g., throat swab, blood, sputum) from the patient.
2. Preparation of the sample by centrifugation or filtration to remove cellular debris and other contaminants.
3. Inoculation of the prepared sample into susceptible host cells, which can be primary cell cultures, continuous cell lines, or embryonated eggs, depending on the type of virus.
4. Incubation of the inoculated cells under appropriate conditions to allow viral replication.
5. Observation for cytopathic effects (CPE), which are changes in the host cells caused by viral replication, such as cell rounding, shrinkage, or lysis.
6. Confirmation of viral presence through additional tests, like immunofluorescence assays, polymerase chain reaction (PCR), or electron microscopy.

Virus cultivation is a valuable tool in diagnostic virology, vaccine development, and research on viral pathogenesis and host-virus interactions. However, it requires specialized equipment, trained personnel, and biosafety measures due to the potential infectivity of the viruses being cultured.

Virus shedding refers to the release of virus particles by an infected individual, who can then transmit the virus to others through various means such as respiratory droplets, fecal matter, or bodily fluids. This occurs when the virus replicates inside the host's cells and is released into the surrounding environment, where it can infect other individuals. The duration of virus shedding varies depending on the specific virus and the individual's immune response. It's important to note that some individuals may shed viruses even before they show symptoms, making infection control measures such as hand hygiene, mask-wearing, and social distancing crucial in preventing the spread of infectious diseases.

Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.

Methanobacteriaceae is a family of archaea within the order Methanobacteriales. These are obligate anaerobes that obtain energy for growth by reducing carbon dioxide to methane, a process called methanogenesis. They are commonly found in anaerobic environments such as wetlands, digestive tracts of animals, and sewage sludge. Some species are thermophilic, meaning they prefer higher temperatures, while others are mesophilic, growing best at moderate temperatures. Methanobacteriaceae are important contributors to the global carbon cycle and have potential applications in bioremediation and bioenergy production.

Methanococcales is an order of methanogenic archaea within the kingdom Euryarchaeota. These are microorganisms that produce methane as a metabolic byproduct in anaerobic environments. Members of this order are distinguished by their ability to generate energy through the reduction of carbon dioxide with hydrogen gas, a process known as CO2 reduction. They are typically found in marine sediments, deep-sea vents, and other extreme habitats. The most well-known genus within Methanococcales is Methanococcus, which includes several species that are capable of living at relatively high temperatures and pressures.

Viral diseases are illnesses caused by the infection and replication of viruses in host organisms. These infectious agents are obligate parasites, meaning they rely on the cells of other living organisms to survive and reproduce. Viruses can infect various types of hosts, including animals, plants, and microorganisms, causing a wide range of diseases with varying symptoms and severity.

Once a virus enters a host cell, it takes over the cell's machinery to produce new viral particles, often leading to cell damage or death. The immune system recognizes the viral components as foreign and mounts an immune response to eliminate the infection. This response can result in inflammation, fever, and other symptoms associated with viral diseases.

Examples of well-known viral diseases include:

1. Influenza (flu) - caused by influenza A, B, or C viruses
2. Common cold - usually caused by rhinoviruses or coronaviruses
3. HIV/AIDS - caused by human immunodeficiency virus (HIV)
4. Measles - caused by measles morbillivirus
5. Hepatitis B and C - caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), respectively
6. Herpes simplex - caused by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2)
7. Chickenpox and shingles - both caused by varicella-zoster virus (VZV)
8. Rabies - caused by rabies lyssavirus
9. Ebola - caused by ebolaviruses
10. COVID-19 - caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Prevention and treatment strategies for viral diseases may include vaccination, antiviral medications, and supportive care to manage symptoms while the immune system fights off the infection.

Simian Virus 40 (SV40) is a polyomavirus that is found in both monkeys and humans. It is a DNA virus that has been extensively studied in laboratory settings due to its ability to transform cells and cause tumors in animals. In fact, SV40 was discovered as a contaminant of poliovirus vaccines that were prepared using rhesus monkey kidney cells in the 1950s and 1960s.

SV40 is not typically associated with human disease, but there has been some concern that exposure to the virus through contaminated vaccines or other means could increase the risk of certain types of cancer, such as mesothelioma and brain tumors. However, most studies have failed to find a consistent link between SV40 infection and cancer in humans.

The medical community generally agrees that SV40 is not a significant public health threat, but researchers continue to study the virus to better understand its biology and potential impact on human health.

Crenarchaeota is a phylum within the domain Archaea. Members of this group are typically extremophiles, living in harsh environments such as hot springs, deep-sea hydrothermal vents, and highly acidic or alkaline habitats. They are characterized by their unique archaeal-type rRNA genes and distinct cell wall composition. Some Crenarchaeota have been found to be involved in nitrogen and carbon cycling in various environments, including the ocean and soil. However, much is still unknown about this group due to the difficulty of culturing many of its members in the lab.

Virus assembly, also known as virion assembly, is the final stage in the virus life cycle where individual viral components come together to form a complete viral particle or virion. This process typically involves the self-assembly of viral capsid proteins around the viral genome (DNA or RNA) and, in enveloped viruses, the acquisition of a lipid bilayer membrane containing viral glycoproteins. The specific mechanisms and regulation of virus assembly vary among different viral families, but it is often directed by interactions between viral structural proteins and genomic nucleic acid.

A plant virus is not defined in medical terms, as viruses are typically considered within the context of living organisms and plants are not classified as such. However, I can provide a general virology definition for you:

Plant viruses are small infectious agents that consist of nucleic acid (DNA or RNA) enclosed in a protein coat. They infect various plant species, causing a wide range of symptoms and diseases, which can result in significant economic losses in agriculture and horticulture. Plant viruses lack the ability to replicate outside a host cell, and they rely on the host's metabolic machinery for their reproduction. They can be transmitted through various means, such as insect vectors, seeds, or mechanical contact.

Archaeal chromosomes refer to the genetic material present in Archaea, a domain of single-celled microorganisms. Like bacteria and eukaryotes, Archaea have their genetic material organized into a single circular chromosome, which is typically smaller than bacterial chromosomes. The archaeal chromosome contains all the genetic information necessary for the organism's survival, including genes coding for proteins, RNA molecules, and regulatory elements that control gene expression.

Archaeal chromosomes are structurally similar to bacterial chromosomes, with a histone-like protein called histone-like protein A (HLP) that helps compact the DNA into a more condensed form. However, archaeal chromosomes also share some features with eukaryotic chromosomes, such as the presence of nucleosome-like structures and the use of similar mechanisms for DNA replication and repair.

Overall, archaeal chromosomes are an important area of study in molecular biology, as they provide insights into the evolution and diversity of life on Earth.

I'm sorry for any confusion, but "Kentucky" is not a medical term or condition. It is a geographical location, being the name of a state in the United States. If you have any questions related to medical conditions or terminology, I would be happy to try and help answer those for you!

A metagenome is the collective genetic material contained within a sample taken from a specific environment, such as soil or water, or within a community of organisms, like the microbiota found in the human gut. It includes the genomes of all the microorganisms present in that environment or community, including bacteria, archaea, fungi, viruses, and other microbes, whether they can be cultured in the lab or not. By analyzing the metagenome, scientists can gain insights into the diversity, abundance, and functional potential of the microbial communities present in that environment.

Medical Definition of Microbiota:

The community of microorganisms, including bacteria, viruses, fungi, and other microscopic life forms, that inhabit a specific environment or body part. In the human body, microbiota can be found on the skin, in the mouth, gut, and other areas. The largest concentration of microbiota is located in the intestines, where it plays an essential role in digestion, immune function, and overall health.

The composition of the microbiota can vary depending on factors such as age, diet, lifestyle, genetics, and environmental exposures. Dysbiosis, or imbalance of the microbiota, has been linked to various health conditions, including gastrointestinal disorders, allergies, autoimmune diseases, and neurological disorders.

Therefore, maintaining a healthy and diverse microbiota is crucial for overall health and well-being. This can be achieved through a balanced diet, regular exercise, adequate sleep, stress management, and other lifestyle practices that support the growth and maintenance of beneficial microorganisms in the body.

The gastrointestinal (GI) tract, also known as the digestive tract, is a continuous tube that starts at the mouth and ends at the anus. It is responsible for ingesting, digesting, absorbing, and excreting food and waste materials. The GI tract includes the mouth, esophagus, stomach, small intestine (duodenum, jejunum, ileum), large intestine (cecum, colon, rectum, anus), and accessory organs such as the liver, gallbladder, and pancreas. The primary function of this system is to process and extract nutrients from food while also protecting the body from harmful substances, pathogens, and toxins.

Volatile fatty acids (VFA) are a type of fatty acid that have a low molecular weight and are known for their ability to evaporate at room temperature. They are produced in the body during the breakdown of carbohydrates and proteins in the absence of oxygen, such as in the digestive tract by certain bacteria.

The most common volatile fatty acids include acetic acid, propionic acid, and butyric acid. These compounds have various roles in the body, including providing energy to cells in the intestines, modulating immune function, and regulating the growth of certain bacteria. They are also used as precursors for the synthesis of other molecules, such as cholesterol and bile acids.

In addition to their role in the body, volatile fatty acids are also important in the food industry, where they are used as flavorings and preservatives. They are produced naturally during fermentation and aging processes, and are responsible for the distinctive flavors of foods such as yogurt, cheese, and wine.

Collagen Type VI is a type of collagen that is widely expressed in various tissues, including skeletal muscle, skin, and blood vessels. It is a major component of the extracellular matrix and plays important roles in maintaining tissue structure and function. Collagen Type VI forms microfilaments that provide structural support to the basement membrane and regulate cell-matrix interactions. Mutations in the genes encoding collagen Type VI can lead to several inherited connective tissue disorders, such as Bethlem myopathy and Ullrich congenital muscular dystrophy.

Butyrates are a type of fatty acid, specifically called short-chain fatty acids (SCFAs), that are produced in the gut through the fermentation of dietary fiber by gut bacteria. The name "butyrate" comes from the Latin word for butter, "butyrum," as butyrate was first isolated from butter.

Butyrates have several important functions in the body. They serve as a primary energy source for colonic cells and play a role in maintaining the health and integrity of the intestinal lining. Additionally, butyrates have been shown to have anti-inflammatory effects, regulate gene expression, and may even help prevent certain types of cancer.

In medical contexts, butyrate supplements are sometimes used to treat conditions such as ulcerative colitis, a type of inflammatory bowel disease (IBD), due to their anti-inflammatory properties and ability to promote gut health. However, more research is needed to fully understand the potential therapeutic uses of butyrates and their long-term effects on human health.

... archael virus, archeal virus, archae virus, archaeon virus, and archaeon virus. It is common for "archaeal virus" to be ... Within a few years, the term "archaebacterial virus" began to be replaced by "archaeal virus". Since 1990, "archaeal virus" has ... archaeal viruses began to be referred to as viruses, not phages. The trend from "phage" to "virus" when describing archaeal ... Many of these archaeal virus families are unassigned to higher taxa. The highest rank in virus taxonomy is realm, and archaeal ...
Two groups of viruses (called 'verdandiviruses') are related to archaeal and bacterial viruses of the class Caudoviricetes, i.e ... and the third group of viruses (called wyrdviruses) is related to archaea-specific viruses with lemon-shaped virus particles ( ... Alarcón-Schumacher, T.; Erdmann, S. (July 2022). "A trove of Asgard archaeal viruses". Nature Microbiology. 7 (7): 931-932. doi ... All these viruses display very low sequence similarity to other known viruses but are generally related to the previously ...
"The wonderful world of archaeal viruses". Annu Rev Microbiol 67: 565-585. 13 Prangishvili D (2015) "Archaeal viruses: living ... "Diversity of viruses of the hyperthermophilic archaeal genus Aeropyrum, and isolation of the Aeropyrum pernix bacilliform virus ... 6. Mochizuki T, Krupovic M, Pehau-Arnaudet G, Sako Y, Forterre P, and Prangishvili D (2012). "Archaeal virus with exceptional ... Peng, Xu; Garrett, Roger A.; She, QunXin (2012). "Archaeal viruses-novel, diverse and enigmatic". Science China Life Sciences. ...
"Structural and functional studies of archaeal viruses". Journal of Biological Chemistry. 284 (19): 12599-603. doi:10.1074/jbc. ... It is estimated viruses kill 20% of the microorganism biomass each day and that there are 15 times as many viruses in the ... Marine viruses are defined by their habitat as viruses that are found in marine environments, that is, in the saltwater of seas ... A marine virus is more likely to infect cooccurring organisms, those that live in the same region the virus lives in. Therefore ...
Lawrence C. M.; Menon S.; Eilers, B. J. (May 2009). "Structural and functional studies of archaeal viruses". The Journal of ... More than 6,000 virus species have been described in detail. Viruses are found in almost every ecosystem on Earth and are the ... Viruses are submicroscopic infectious agents that replicate inside the cells of organisms. Viruses infect all types of life ... "Virus Taxonomy: 2019 Release". talk.ictvonline.org. International Committee on Taxonomy of Viruses. Archived from the original ...
... ranging from spindle-shaped structures to viruses that resemble hooked rods, teardrops or even bottles. Other archaeal viruses ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ... Other viruses, such as rabies virus, can infect different species of mammals and are said to have a broad range. The viruses ... Quote: "Virus: virus (s.n. II), gen. sing. viri, nom. pl. vira, gen. pl. vīrorum (to be distinguished from virorum, of men)." ...
2009). "Structural and functional studies of archaeal viruses". The Journal of Biological Chemistry. 284 (19): 12599-603. doi: ... Breitbart, M.; Rohwer, F. (2005). "Here a virus, there a virus, everywhere the same virus?". Trends in Microbiology. 13 (6): ... The microorganisms and viruses that can reproduce and complete their life cycle within the host are known as microparasites. ... They can be either RNA or DNA viruses consisting of a single or double strand of genetic material (RNA or DNA, respectively), ...
PMID 20164227.. Rice, G. (2004). "The structure of a thermophilic archaeal virus shows a double-stranded DNA viral capsid type ... Sulfolobus turreted icosahedral virus 1 (formerly Sulfolobus turreted icosahedral virus) is a species of virus that infects the ... The genome has a G+C content of 36%.[citation needed] Unlike other viruses that either lyse or bud from their hosts this virus ... Virus Taxonomy: 2014 Release, International Committee on Taxonomy of Viruses. Accessed on line Nov. 25, 2015. Happonen, L. J.; ...
The major capsid protein structure and virion organization of bicaudaviruses are similar to those of archaeal viruses from the ... Bicaudaviridae is a family of hyperthermophilic archaeal viruses. Members of the genus Acidianus serve as natural hosts. There ... "Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome". Cell. 185 (8): 1297-1307.e11. ... Structural and genomic properties of the hyperthermophilic archaeal virus ATV with an extracellular stage of the reproductive ...
... is a family of hyperthermophilic archaeal viruses. Crenarchaea of the genera Pyrobaculum and Thermoproteus serve ... "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 24 May 2021. Häring ... "Morphology and genome organization of the virus PSV of the hyperthermophilic archaeal genera Pyrobaculum and Thermoproteus: a ... Prangishvili, D; Krupovic, M; ICTV Report Consortium (2018). "ICTV Virus Taxonomy Profile: Globuloviridae". The Journal of ...
Quemin ER, Quax TE (5 June 2015). "Archaeal viruses at the cell envelope: entry and egress". Frontiers in Microbiology. 6: 552 ... Cell-wall-containing Archaea are also lysed by specialized pseudomurein-cleaving lysins, while most archaeal viruses employ ... In order to solve such a problem, phage viruses synthesize another protein called holin which binds to the cell membrane and ... Visweswaran GR, Dijkstra BW, Kok J (November 2010). "Two major archaeal pseudomurein endoisopeptidases: PeiW and PeiP". Archaea ...
"Targeted diversity generation by intraterrestrial archaea and archaeal viruses". Nature Communications. 6 (1): 6585. Bibcode: ... Archaean viruses (e.g. ANMV-1), temperate phages (e.g. Hankyphage and CrAss-like phage), and lytic phages. DGRs benefit their ... Viruses. 12 (5): 573. doi:10.3390/v12050573. ISSN 1999-4915. PMC 7290462. PMID 32456083. Hedzet, Stina; Accetto, Tomaž; Rupnik ...
"Evolutionary genomics of archaeal viruses: Unique viral genomes in the third domain of life". Virus Research. 117 (1): 52-67. ... Icerudivirus is a genus of viruses in the family Rudiviridae. These viruses are non-enveloped, stiff-rod-shaped viruses with ... "A Novel Virus Family, the Rudiviridae: Structure, Virus-Host Interactions and Genome Variability of the Sulfolobus Viruses ... SIRV2 is a lytic virus that kills the host cell as a consequence of elaborated mechanisms orchestrated by the virus. Massive ...
Sulfolobus islandicus rod-shaped virus 2, also referred to as SIRV2, is an archaeal virus whose only known host is the archaeon ... This virus belongs to the family Rudiviridae. Like other viruses in the family, it is common in geothermal environments. SIRV2 ... "First insights into the entry process of hyperthermophilic archaeal viruses". Journal of Virology. 87 (24): 13379-85. doi: ... virus-host interactions and genome variability of the sulfolobus viruses SIRV1 and SIRV2". Genetics. 152 (4): 1387-96. doi: ...
Not only eukaryotic viruses integrate into the genomes of their hosts; many bacterial and archaeal viruses also employ this ... Krupovic M, Prangishvili D, Hendrix RW, Bamford DH (2011). "Genomics of bacterial and archaeal viruses: dynamics within the ... A provirus is a virus genome that is integrated into the DNA of a host cell. In the case of bacterial viruses (bacteriophages ... A provirus not only refers to a retrovirus but is also used to describe other viruses that can integrate into the host ...
Krupovic M, Prangishvili D, Hendrix RW, Bamford DH (December 2011). "Genomics of bacterial and archaeal viruses: dynamics ... Phagemid Polyphage RNA viruses Transduction Viriome Virophage, viruses that infect other viruses Padilla-Sanchez V (2021). " ... August 2017). "Virus found in a boreal lake links ssDNA and dsDNA viruses". Proceedings of the National Academy of Sciences of ... a virus parasitic on bacteria." D'Hérelle called the virus a bacteriophage, a bacteria-eater (from the Greek phagein, meaning " ...
Krupovic M, Prangishvili D, Hendrix RW, Bamford DH (2011). "Genomics of bacterial and archaeal viruses: dynamics within the ... The cell may fill with new viruses until it lyses or bursts, or it may release the new viruses one at a time in an exocytotic ... A virus following a lytic cycle is called a virulent virus. Prophages are important agents of horizontal gene transfer, and are ... This mechanism eventually will lead to the release of the virus as the host cell splits open and the viral DNA is able to ...
Archaeal-specific viruses target only archaean species and currently include 12 families. Numerous unique, previously ... Mochizuki T, Krupovic M, Pehau-Arnaudet G, Sako Y, Forterre P, Prangishvili D (August 2012). "Archaeal virus with exceptional ... Pietilä MK, Demina TA, Atanasova NS, Oksanen HM, Bamford DH (June 2014). "Archaeal viruses and bacteriophages: comparisons and ... Notably, the latter virus has the largest currently reported ssDNA genome. Defenses against these viruses may involve RNA ...
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"Bacterial and Archaeal Viruses of Himalayan Hot Springs at Manikaran Modulate Host Genomes". Frontiers in Microbiology. 9: 3095 ...
"Structure of a filamentous virus uncovers familial ties within the archaeal virosphere". Virus Evolution. 6 (1): veaa023. doi: ... Liu, Y; Brandt, D; Ishino, S; Ishino, Y; Koonin, EV; Kalinowski, J; Krupovic, M; Prangishvili, D (2019). "New archaeal viruses ... "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 14 May 2021. Arnold ... "A filamentous archaeal virus is enveloped inside the cell and released through pyramidal portals". Proceedings of the National ...
"Taxonomy of prokaryotic viruses: update from the ICTV bacterial and archaeal viruses subcommittee". Archives of Virology. 161 ( ... The virus starts by breaking down all E. coli genetic material. This is known as the lytic cycle. The virus can now occupy the ... Enterobacter virus CC31 is a dsDNA virus lacking an RNA intermediate. The dsDNA is contained within an icosahedral capsid of ... Escherichia virus CC31, formerly known as Enterobacter virus CC31, is a dsDNA bacteriophage of the subfamily Tevenvirinae ...
... existing bacterial virus and 2 archaeal virus species" (PDF). International Committee on Taxonomy of Viruses. Retrieved 29 ... "Virus taxonomy: sixth report of the International Committee on Taxonomy of Viruses" (PDF). Archives of Virology. 10: 350-4. ... Double-stranded RNA viruses Murphy FA, Fauquet CM, Bishop DH, Ghabrial SA, Jarvis AW, Martelli GP, Mayo MA, Summers MD (1995 ... Φ6 has been studied as a model to understand how segmented RNA viruses package their genomes, its structure has been studied by ...
... existing bacterial virus and 2 archaeal virus species" (PDF). International Committee on Taxonomy of Viruses (ICTV). Retrieved ... Escherichia virus T5, sometimes called Bacteriophage T5 is a caudal virus within the family Demerecviridae. This bacteriophage ...
Li, Sen; Yang, Jie (21 August 2014). "System analysis of synonymous codon usage biases in archaeal virus genomes". Journal of ...
"Diversity of viruses of the hyperthermophilic archaeal genus Aeropyrum, and isolation of the Aeropyrum pernix bacilliform virus ... Double-stranded DNA viruses, Virus families, All stub articles, Virus stubs). ... "Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging". Nature Communications. 8 (1): 1436. Bibcode ... Clavaviridae is a family of double-stranded viruses that infect archaea. This family was first described by the team led by D. ...
... (SIFV) is an archaeal virus, classified in the family Lipothrixviridae within the order ... Archaeal viruses, Ligamenvirales, All stub articles, Virus stubs). ... "A filamentous archaeal virus is enveloped inside the cell and released through pyramidal portals". Proceedings of the National ... Unlike in the case of some other archaeal viruses (e.g., rudiviruses and turriviruses), the SIFV VAPs have a hexagonal base (i. ...
Krupovic, M; Forterre, P; Bamford, DH (2010). "Comparative analysis of the mosaic genomes of tailed archaeal viruses and ... Different GTA types have originated independently from viruses in several bacterial and archaeal lineages. These cells produce ... Gene transfer agents (GTAs) are DNA-containing virus-like particles that are produced by some bacteria and archaea and mediate ... Virus Evolution. 3 (2): vex036. doi:10.1093/ve/vex036. PMC 5721377. PMID 29250433. Tamarit D, Neuvonen MM, Engel P, Guy L, ...
Acidianus filamentous virus 1 coat proteins display a helical fold spanning the filamentous archaeal viruses lineage. PNAS 106 ... "Structure of a filamentous virus uncovers familial ties within the archaeal virosphere". Virus Evolution. 6 (1): veaa023. doi: ... "Virus Taxonomy: 2022 Release". International Committee on Taxonomy of Viruses (ICTV). March 2023. Retrieved 14 September 2023 ... Members of the Ligamenvirales are structurally related to archaeal viruses of the family Tristromaviridae which, similar to ...
"Structure of a filamentous virus uncovers familial ties within the archaeal virosphere". Virus Evolution. 6 (1): veaa023. doi: ... and the rabies virus, as well as the first virus to be discovered, Tobacco mosaic virus. Reverse transcribing viruses are a ... "Virus Taxonomy: 2019 Release". International Committee on Taxonomy of Viruses. International Committee on Taxonomy of Viruses. ... Riboviria mostly contains eukaryotic viruses, and most eukaryotic viruses, including most human, animal, and plant viruses, ...
... archael virus, archeal virus, archae virus, archaeon virus, and archaeon virus. It is common for "archaeal virus" to be ... Within a few years, the term "archaebacterial virus" began to be replaced by "archaeal virus". Since 1990, "archaeal virus" has ... archaeal viruses began to be referred to as viruses, not phages. The trend from "phage" to "virus" when describing archaeal ... Many of these archaeal virus families are unassigned to higher taxa. The highest rank in virus taxonomy is realm, and archaeal ...
The wonderful world of archaeal viruses. Add to your list(s) Download to your calendar using vCal ... University of Cambridge , Talks.cam , Cambridge Virology Seminars , The wonderful world of archaeal viruses ...
A closed Candidatus Odinarchaeum genome exposes Asgard archaeal viruses. View ORCID ProfileDaniel Tamarit, View ORCID Profile ... A closed Candidatus Odinarchaeum genome exposes Asgard archaeal viruses Message Subject (Your Name) has forwarded a page to you ... We find related viruses in sequence data from thermophilic environments and in the genomes of diverse prokaryotes, including ... These novel viruses open research avenues into the ecology and evolution of Asgard archaea. ...
Sulfolobus turreted icosahedral virus (STIV) is well characterized for an archaeal virus. Still, no information is available ... Attachment to host pili is now emerging as a common theme for archaeal viruses. Furthermore, the isolation of the new archaeal ... The isolation of a new archaeal virus, Thermoproteus Piliferous Virus 1 (TSPV1), is also presented here. The TSPV1 virion has ... Little is known regarding the attachment and entry process for any archaeal virus. The virus capsid serves multiple biological ...
Genetics, biochemistry and structure of the archaeal virus STIV. J. Fulton, B.B. Bothner, M. Lawrence, J.E. Johnson, T. Douglas ... M. Young "Genetics, biochemistry and structure of the archaeal virus STIV" Biochemical Society Transactions (2009) 37, 114-117. ... Reversal of Catalytic Material Substrate Selectivity through Partitioning of Polymers in Hierarchically Ordered Virus-like ... Reversal of Catalytic Material Substrate Selectivity through Partitioning of Polymers in Hierarchically Ordered Virus-like ...
Archaeal Virology. Krupovic Mart. Krupovic Mart. Cell biology of archaeal virus infection. CdV ED 515. ... Virus & Immunity Unit. Schwartz Olivier. Schwartz Olivier. SARS-CoV-2 fusion, replication and antiviral responses.. BioSPC ED ...
... the Bacterial and Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) has moved the ... This revealed new members of the N4-like phage group, from 33 members in 2015 to 115 N4-like viruses in 2020. Using new ... It encodes an extremely large virion-associated RNA polymerase unique for bacterial viruses that became characteristic for this ... classification and taxonomy of bacterial viruses from mere morphological approaches to genomic and proteomic methods. The ...
Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity. He, F., Bhoobalan-Chitty, Y., Van, L. B., ... Structural basis for inhibition of an archaeal CRISPR-Cas type I-D large subunit by an anti-CRISPR protein. Manav, M. C., Van, ...
Notably, PD patients had fewer gut viruses, including bacterial and archaeal phages. Based on the abundance of six different ... and also accounts for bugs such as viruses and fungi. ...
Viruses [B04]. *Archaeal Viruses [B04.100]. *Lipothrixviridae [B04.100.450]. *DNA Viruses [B04.280]. *Lipothrixviridae [B04.280 ...
The gut microbiota gathers bacterial, fungus, archaeal, and virus communities that live in the gut in symbiosis with our ... fungi and viruses in these food storage enclosures (87, 89, 90). Adding Ag-NP directly to final food packaging also gives it ...
... and archaeal viruses from the rudiviridae, bicaudaviridae and fuselloviridae. Prokaryotic communities in fluids percolating ... Our data also suggest that viruses contribute to the mortality of deep subsurface prokaryotes through cell lysis, and viruses ... Viruses in the oceanic basement : An integral component of microbial life. Abstract. Fluids contained in the basalt-hosted deep ... We detected viruses within these fluids by TEM and epifluorescence microscopy in samples collected from 2010 to 2014. Viral ...
Novel viral genomes identified from six metagenomes reveal wide distribution of archaeal viruses & high viral diversity in ... Acidianus tailed spindle virus: a new large tailed spindle virus discovered by culture-independent methods. J. Virology. In ... Honey Bee Infecting Lake Sinai Viruses. Viruses. 2015, 7(6), 3285-3309. DOI:10.3390/v7062772. ... a founding member of a new family of archaeal viruses. Journal of Virology. October 2017. DOI: 10.1128/JVI.00925-17. ...
... an archaeal lytic virus targeting a member of the Methanomicrobiales. Viruses 13 (10), 1934 (2021) ...
... and from thermophilic archaeal viruses in the families Bicaudaviridae, Rudiviridae, and Fuselloviridae. These results imply ... which highlights the importance of localized hypermutation in manipulating host-parasite interactions for archaeal viruses from ... Viruses in the Oceanic Basement. Authors: Olivia Nigro, Sean P. Jungbluth, Huei-Ting Lin, Chih-Chiang Hsieh, Jaclyn A. Miranda ... Concentrations of virus-like particles in the fluids were on the order of 0.2 -2 x 105 ml-1 (n=8), higher than prokaryote-like ...
... eukaryotic viruses, and archaeal viruses. Viruses do not infect hosts in another domain of life, and therefore lateral gene ... Viruses are tidily categorized into three groups according to the hosts they infect - bacteriophages, ... transfer is limited (giant DNA viruses might be exceptions). Now there is evidence for lateral gene transfer between eukaryotes ...
... archaeal and bacterial viruses, whether the research involves the use of clinical, ecological, biological, or biochemical ... including smallpox virus and vaccinia virus (smallpox vaccine). The event happens every two years and typically draws many of ... and viruses to gain comprehensive guidance with up-to-date examples in the use of Next Generation Sequencing (NGS) technology ... as well as progress made in technology to improve the yield of vaccine viruses. ASV is also an important meeting to aid in ...
The Structure of a Double C2H2 Zinc Finger Protein from a Hyperthermophilic Archaeal Virus in the Absence of DNA. ... Solution structure of the zinc finger AFV1p06 protein from the hyperthermophilic archaeal virus AFV1. ... CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT. ... Atomic CryoEM Structure of a Nonenveloped Virus Suggests How Membrane Penetration Protein is Primed for Cell Entry. ...
The Structure of a Double C2H2 Zinc Finger Protein from a Hyperthermophilic Archaeal Virus in the Absence of DNA. ... Solution structure of the zinc finger AFV1p06 protein from the hyperthermophilic archaeal virus AFV1. ... CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT. ... Atomic CryoEM Structure of a Nonenveloped Virus Suggests How Membrane Penetration Protein is Primed for Cell Entry. ...
In spite of their broad abundance, viruses, in particular bacteriophages, remain largely unknown since only about 20% of ... Eukaryotic Viruses and Phages Orthologous Groups). To do this, we examine the non-redundant viral diversity stored in public ... Viruses, far from being just parasites affecting hosts fitness, are major players in any microbial ecosystem. ... the search of orthologous groups as potential markers to viral taxonomy from bacteriophages and included eukaryotic viruses, ...
Targetted diversity generation by intraterrestrial archaea and archaeal viruses. Nature Communications 6. doi:10.1038/ ... Current projects examine variation in genomes and proteins of bacteria, archaea, and viruses, while considering the ecological ... Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating ... with additional interest in microbe-virus dynamics. ...
Cell-wall-containing Archaea are also lysed by specialized pseudomurein-cleaving lysins, while most archaeal viruses employ ... Lysin is a type of enzymatic substance produced by bacteriophages (viruses that infect bacteria) that can break down the cell ...
c) Archaeal virus-host interactions, Faculty for Biology, University of Freiburg (Germany). (d) Biology of Archaea and Viruses ... However, with the structure of the archaeal switch complex still unknown, future studies need to unveil this connection and the ... with cell biology reveals how the conserved signal transduction machinery in bacteria and archaea is coupled to the archaeal ...
Moreover, our study focuses on the bacterial and archaeal microbiota (not accounting for viruses and eukaryotes60) and is ... Fecal microbiota transplantation involves the transfer of gut microbes, viruses and luminal content to modulate a recipients ... functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses. Nucleic Acids Res. 47 ...
Future studies on archaeal viruses, combined with the knowledge on viruses of bacteria and eukaryotes, should lead to a better ... Archaeal viruses, especially viruses that infect hyperthermophilic archaea of the phylum Crenarchaeota, constitute one of the ... However, owing to recent substantial research efforts by several groups, archaeal viruses are starting to gradually reveal ... Genomics and biology of Rudiviruses, a model for the study of virus-host interactions in Archaea. ...
Crystal structure and initial characterization of a novel archaeal-like Holliday junction-resolving enzyme from Thermus ... Thermus virus IN93 (Matsushita & Yanase, 2008. ), Thermus phage φTMA (Tamakoshi et al., 2011. ), Thermus virus P23-77 ( ... In this study, carried out within the frame of the VIRUS-X project (Aevarsson et al., 2021. ), a novel archaeal-like Hj- ... Several non-archaeal-like Hj-resolving enzymes from viruses have had their structures determined and/or their activities ...
... studying strains of Avian flu virus, identifying parvovirus B in skeletal remains, Ebola virus in Sierra Leone, a novel ... As a virologist, you want results quickly, reliably, and reproducibly, whether you are studying archaeal viruses in Yellowstone ... whether you are studying archaeal viruses in Yellowstone Park, studying strains of Avian flu virus, identifying parvovirus B in ... skeletal remains, Ebola virus in Sierra Leone, a novel Flexivirus, or Hepatitis B subtype distribution in Brazil. ...
unclassified archaeal viruses unclassified bacterial viruses unclassified virophages unclassified viruses Varidnaviria (clade) ...
  • An archaeal virus is a virus that infects and replicates in archaea, a domain of unicellular, prokaryotic organisms. (wikipedia.org)
  • Some environments, such as acidic hot springs, are almost exclusively populated by archaea, so these environments are highly useful for studying how archaeal viruses interact with their hosts. (wikipedia.org)
  • Since 1990, "archaeal virus" has been the dominant term when describing viruses that infect archaea. (wikipedia.org)
  • The majority of viruses infecting hyperthermophilic archaea display unique virion architectures and are evolutionarily unrelated to viruses of bacteria and eukaryotes. (pasteur.fr)
  • The lack of relationships to other known viruses suggests that the mechanisms of virus-host interaction in Archaea are also likely to be distinct. (pasteur.fr)
  • Viruses whose hosts are in the domain ARCHAEA . (nih.gov)
  • AbstractAsgard archaea have recently been identified as the closest archaeal relatives of eukaryotes. (uibk.ac.at)
  • We found related viruses in the genomes of diverse prokaryotes from geothermal environments, including other Asgard archaea. (uibk.ac.at)
  • These viruses open research avenues into the ecology and evolution of Asgard archaea. (uibk.ac.at)
  • His research group discovered a new group of archaea, the Asgard archaea, providing new, compelling evidence that complex cellular life evolved from an archaeal ancestor that already contained several eukaryotic traits. (wur.nl)
  • In recent years, the study of eukaryogenesis made a major leap forward thanks to the discovery and exploration of a new phylum of archaea that received the picturesque name Asgard , after the mythical abode of the Nordic gods (all the names of archaeal taxa within Asgard come from particular deities, the first one to be discovered being the mischievous Loki). (springernature.com)
  • Considering this, we assumed that eukaryotic viruses would have evolved from viruses of archaea. (nih.gov)
  • In the microbiota analyses, they found alterations in all three domains of life (fungi, archaea, and bacteria), as well as viruses, in relation to the development of colorectal cancer. (who.int)
  • Guttaviridae is a family of enveloped viruses infecting hyperthermophilic archaea (Table 1. (ictv.global)
  • The filtered remaining reads are taxonomically assigned using a proprietary workflow against a microbial genome database containing all complete refseq genomes from viruses, bacteria, fungi, and archaea. (nih.gov)
  • All known archaeal viruses have genomes made of deoxyribonucleic acid (DNA), but some may contain ribonucleic acid (RNA) genomes. (wikipedia.org)
  • The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. (nature.com)
  • Here we revisited the use of genomes and their protein content as a means for developing a viral taxonomy for bacterial and archaeal viruses. (nih.gov)
  • 15-) using a local database for identification of all viruses, bacteria and archaeal genomes extracted from the NCBI refseq database (downloaded 15/04/2017). (cdc.gov)
  • The resulting contigs were scanned against several BLAST ( 12 ) pre-generated databases downloaded from NCBI ( nt , tsa_nt , ref_prok_rep_genomes , ref_viruses_rep_genomes , and vector - downloaded 15/04/2017). (cdc.gov)
  • 2023. A compendium of bacterial and archaeal single-cell amplified genomes from oxygen deficient marine waters. (aquaticmicro.org)
  • The viromes of eukaryotes and prokaryotes are dramatically different, but nevertheless, the prokaryotic roots of the majority of eukaryotic viruses can be traced by comparison of viral genomes and virion structures. (springernature.com)
  • Researchers sequenced 61 Zika virus genomes isolated from patients in the region to reconstruct viral movements. (genomeweb.com)
  • Archaeal viruses were originally referred to as "bacteriophages" or simply "phages", terms shared with bacterial viruses. (wikipedia.org)
  • Utilizing bacteria, archaebacteria, bacteriophages and other non-virus microorganisms, this initiative will support research projects designed to study the underlying mechanisms of the complex interactions between microorganisms, tumor, and immune system. (phage.directory)
  • A family of BACTERIOPHAGES and ARCHAEAL VIRUSES which are characterized by complex contractile tails. (bvsalud.org)
  • Tailed bacteriophages are the most abundant and diverse viruses in the world, with genome sizes ranging from 10 kbp to over 500 kbp. (ox.ac.uk)
  • And here came a surprise: we realized that all main types of viruses of eukaryotes apparently originated from viruses infecting bacteria (bacteriophages) rather than archaeal viruses. (springernature.com)
  • The former includes viruses found in the realms Duplodnaviria and Varidnaviria, which likely have ancient origins preceding the LACA, and the latter includes the realm Adnaviria and all archaeal virus families unassigned to higher taxa, which are thought to have more recent origins from non-viral mobile genetic elements such as plasmids. (wikipedia.org)
  • Total extracted nucleic acid was also tested for the presence of notifiable transboundary ruminant viral pathogens using previously established diagnostic real-time RT-PCR assays for foot-and-mouth disease virus ( 2 ), blue-tongue virus ( 3 ), peste des petits ruminants virus ( 4 ), capripox viruses ( 5 ) and epizootic haemorrhagic disease virus ( 6 ). (cdc.gov)
  • We then highlight the genomic features of hyperthermophilic archaeal viruses and emphasize how structural and functional genomic approaches have shed light into the characterization of viral proteins. (dzumenvis.nic.in)
  • The outer protein protective shell of a virus, which protects the viral nucleic acid. (lookformedical.com)
  • Epidemiological studies in humans and experimental studies in animal have shown that viral infections can induce or protect from autoimmunopathologies depending on several factors including genetic background, host-elicited immune responses, type of virus strain, viral load, and the onset time of infection. (mdpi.com)
  • This is the latest in our series of efforts to address the fundamental problems in the evolution of viruses, the previous installments dealing with the origin of viruses , the virome of the LUCA and the logic of virus evolution , that is, what types of genes viruses capture from the hosts and how these genes are adapted for viral functions. (springernature.com)
  • Sequencing in this manner (i.e., non-targeted) gives us access to all taxonomic sources of DNA fragments in circulation (human, bacterial, fungal, viral, and archaeal) and enables the discovery and downstream employment of complex, multi-analyte diagnostic signatures. (nih.gov)
  • It has been shown to inhibit the replication of multiple human viruses by producing a molecule called ddhCTP, which acts as a chain terminator for viral RNA polymerase (Gizzi et al. (mdmlab.fr)
  • All microbial members (bacterial, archaeal, bacteriophage, viral, and fungal) have been included in this baseline dataset and both phylogenetic marker gene sequence [e.g. 16S rRNA, 18S rRNA, and internal transcribed spacer region (ITS)] and metagenomic whole genome shotgun sequence data were generated. (nih.gov)
  • In the first endosymbiosis, a bacterial host engulfed an Asgard archaeon, preventing archaeal viruses from entry owing to a lack of archaeal virus receptors on the external membranes. (nih.gov)
  • There is now effectively no doubt that the archaeal parent of eukaryotes was an Asgard archaeon. (springernature.com)
  • To gain insights into archaeal virus-host interactions, we studied the life cycle of the enveloped, ∼2-μm-long Sulfolobus islandicus filamentous virus (SIFV), a member of the family Lipothrixviridae infecting a hyperthermophilic and acidophilic archaeon Saccharolobus islandicus LAL14/1. (pasteur.fr)
  • To address this problem while accounting for some aspects of eukaryotic biochemistry, a different model has been discussed in the literature, one where a bacterium first engulfed an archaeon and the archaeal membrane was thereby lost, and then a second bacterial endosymbiont became the mitochondrion. (nih.gov)
  • We compiled an inventory of eukaryotic hosts of all major virus taxa and reconstructed the LECA virome by inferring the origins of these groups of viruses. (nih.gov)
  • The origin of the LECA virome can be traced back to a small set of bacterial-not archaeal-viruses. (nih.gov)
  • The authors argue that the virome of the last eukaryotic common ancestor is bacterial, rather than archaeal, providing support for a syntrophic model of eukaryogenesis with two endosymbiosis events. (springernature.com)
  • Therefore, reconstruction of ancestral life forms can hardly be considered complete without an accompanying reconstruction of the entirety of viruses that infected them, the virome, for short. (springernature.com)
  • Not unexpectedly, the reconstructed virome of LUCA resembled today's prokaryote viromes, whereas the virome of LECA included the main groups of viruses of eukaryotes. (springernature.com)
  • My colleagues and I addressed this question by reconstructing a virome (the collection of viruses that infect a given host species) of our two-billion-year-old eukaryotic ancestor. (nih.gov)
  • First, we found that the virome of our ancestor eukaryotes was nearly as complex as that of modern organisms-it seems that as far as viruses are concerned, not much has changed in two billion years. (nih.gov)
  • Extreme thermal environments represent a habitat for viruses with remarkable morphological diversity and unique genome contents, many of which have not been described in moderate temperature environments. (dzumenvis.nic.in)
  • In this study, we used a wide range of complementary methods - including comparative genomics, core genome analysis, and marker gene phylogenetics - to show that the group of Bacillus phage SPO1-related viruses previously classified into the Spounavirinae subfamily, is clearly distinct from other members of the family Myoviridae and its diversity deserves the rank of an autonomous family. (ox.ac.uk)
  • At least 160 proteins are involved in replicating the human genome, and at least 40 diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than 40 by DNA viruses. (cshlpress.com)
  • Genome map of Aeropyrum pernix ovoid virus 1. (ictv.global)
  • An updated bacterial and archaeal reference genome collection is available! (nih.gov)
  • We report the division of the former Bacterial and Archaeal Viruses Subcommittee in two separate Subcommittees, welcome new members, a new Subcommittee Chair and Vice Chair, and give an overview of the new taxa that were proposed in 2020, approved by the Executive Committee and ratifed by vote in 2021. (uwc.ac.za)
  • In this article, we - the Bacterial Viruses Subcommittee and the Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) - summarise the results of our activities for the period March 2020 - March 2021. (uwc.ac.za)
  • This prompted us, the Bacterial and Archaeal Viruses Subcommittee of the International Committee on Taxonomy of Viruses (ICTV) to consider overall reorganization of phage taxonomy. (ox.ac.uk)
  • indeed, all organisms on earth, from bacteria to amoeba to plants and animals, are infected by multiple, diverse viruses. (nih.gov)
  • Thanks to a powerful new methodology known as metagenomics-simply put, the sequencing of all DNA or RNA from any environment without growing organisms in the lab-we can now explore the diversity of viruses incomparably better than we possibly could even a decade ago. (nih.gov)
  • My group has been studying the evolution of viruses for years, and one of the fascinating questions we asked was, if we compare the rapidly expanding diversity of known viruses that infect all kinds of organisms, might it be possible to peer into the distant past and figure out what viruses were infecting our distant ancestors? (nih.gov)
  • RNA polymerase enzymes are essential to life and are found in all organisms and many viruses . (wikidoc.org)
  • Taxonomic classification of archaeal and bacterial viruses is challenging, yet also fundamental for developing a predictive understanding of microbial ecosystems. (nih.gov)
  • Our finding that eukaryotic viruses evolved from bacterial viruses seems to strongly favor this two-symbioses model for the origin of eukaryotic cells. (nih.gov)
  • Second, we found that all viruses that infect eukaryotes evolved from those that infect bacteria. (nih.gov)
  • However, this was not the case-the viruses that infect eukaryotes apparently came from bacteria ! (nih.gov)
  • Since 2000, methods such as metagenomics have identified many novel archaeal viruses, and methods such as cryogenic electron microscopy and gene synteny have helped to better understand their evolutionary history. (wikipedia.org)
  • Studying the infection mechanisms of archaeal viruses can provide insight into the evolutionary history of viruses and help to understand adaptation to extreme environments. (phage.directory)
  • Influenza A virus (IAV) infection relies on the action of the hemagglutinin (HA) and neuraminidase (NA) membrane proteins. (bvsalud.org)
  • Proteins found in any species of virus. (lookformedical.com)
  • 7. Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in eukaryotes, bacteria, viruses and plasmids. (nih.gov)
  • We showed that eukaryotic viperin originated from a clade of bacterial and archaeal proteins that protect against phage infection. (mdmlab.fr)
  • More generally, i.e., as applied to non-phage viruses or other pathogens, see infection . (archaealviruses.org)
  • a href="mixed_infection.html">mixed infection ' when virus particles of different strains become adsorbed on the same bacterium. (archaealviruses.org)
  • Dr Simona Pilotto , the lead author of the second study elaborates on her work: The inhibition of RNAP and the resulting attenuation of the transcriptome plays a crucial role in the interaction between viruses and their hosts during infection. (lon.ac.uk)
  • TFS4 is encoded by the Sulfolobus host and is expressed in response to infection with the Sulfolobus Turreted Icosahedral Virus (STIV). (lon.ac.uk)
  • DefenseFinder will facilitate large-scale genomic analysis of antiviral defense systems and the study of host-virus interactions in prokaryotes. (mdmlab.fr)
  • Archaeal viruses, like their hosts, are found worldwide, including in extreme environments inhospitable to most life such as acidic hot springs, highly saline bodies of water, and at the bottom of the ocean. (wikipedia.org)
  • How archaeal viruses interact with their hosts and the environment is largely unknown. (wikipedia.org)
  • Here we define influenza virus dynamics in human hosts through sequencing of 249 specimens from 200 individuals collected over 6290 person-seasons of observation. (elifesciences.org)
  • Viruses whose hosts are bacterial cells. (lookformedical.com)
  • All cellular life forms (with a few explainable exceptions) are hosts to multiple viruses . (springernature.com)
  • The approach used for the reconstruction of ancestral viromes is simple and straightforward: we map different groups of viruses on the phylogenetic tree of the hosts and construct what is called the most parsimonious scenario of evolution, that is, the shortest sequence of events (in this case, gain or loss of a given virus group) that could generate the observed distribution. (springernature.com)
  • He is also trying to understand structure-function relationships in complex archaeal lipids. (stanford.edu)
  • Specifically, 16 multi-kingdom markers, including 11 bacterial, 4 fungal, and 1 archaeal feature, achieved good performance in diagnosing patients with colorectal cancer. (who.int)
  • Archaeal genetic system and its viruses. (ku.dk)
  • Deoxyribonucleic acid that makes up the genetic material of viruses. (lookformedical.com)
  • Despite this, those that have been studied are highly diverse and classified to more than 20 families, many of which show no relation to any other known viruses. (wikipedia.org)
  • This article is a summary of the activities of the ICTV's Bacterial and Archaeal Viruses Subcommittee for the years 2018 and 2019. (arizona.edu)
  • Viruses (2018 Jun 6) 10. (nih.gov)
  • Currently, Ahanjit is working on physical mechanisms of fusion of enveloped viruses with lipid membranes. (stanford.edu)
  • This is a model for the origin of eukaryotic cells and their viruses. (nih.gov)
  • His research group has a broad research focus and works on a variety of scientific questions connected to microbial diversity and evolution that cover all Domains of Life, as well as viruses. (wur.nl)
  • At around the same time as the adoption of archaebacteria as a name, though, archaeal viruses began to be referred to as viruses, not phages. (wikipedia.org)
  • The first known archaeal virus was described in 1974 and since then, a large diversity of archaeal viruses have been discovered, many possessing unique characteristics not found in other viruses. (wikipedia.org)
  • Much of the diversity observed in archaeal viruses is their morphology. (wikipedia.org)
  • Research areas in archaeal virology include gaining a better understanding of their diversity and learning about their means of replication. (wikipedia.org)
  • Here, we summarize the state-of-the-art knowledge on the diversity and virion structures of crenarchaeal viruses. (dzumenvis.nic.in)
  • Spang, A., Caceres, E.F. and Ettema, T.J.G. (2017) Genomic exploration of the diversity, ecology, and evolution of the archaeal domain of life. (wur.nl)
  • Yet, due to historical reasons, all this diversity is confined to a single virus order - Caudovirales, composed of just four families: Myoviridae, Siphoviridae, Podoviridae, and the newly created Ackermannviridae family. (ox.ac.uk)
  • And that diversity is nothing short of astonishing: a recent estimate my colleagues and I developed using this methodology suggests that there could be as many as a billion distinct virus species on our planet. (nih.gov)
  • To do this, we mapped the current diversity of viruses on the evolutionary tree of life, then applied some simple mathematical methods to infer which of them were already present in that distant common ancestor. (nih.gov)
  • Previously, we demonstrated that human immunodeficiency virus type 2 (HIV-2) immature particles possess a distinct and extensive Gag lattice morphology. (bvsalud.org)
  • A large portion of the genes encoded by archaeal viruses have no known function or homology to any other genes. (wikipedia.org)
  • Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium. (lookformedical.com)
  • For some archaeal viruses in hypersaline environments, the level of salinity can affect infectivity and virus behavior. (wikipedia.org)
  • Taken together, our findings provide the first 3D organization of HIV-2 immature Gag lattice and important insights into both HIV Gag lattice stabilization and virus maturation. (bvsalud.org)
  • Growing two long filamentous tails may help an archaeal virus to survive in a hostile environment. (acguanacaste.ac.cr)
  • We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. (nature.com)
  • To demonstrate the value of this resource, we used the GEM catalog to perform metagenomic read recruitment across Earth's biomes, identify novel biosynthetic capacity, perform metabolic modeling and predict host-virus linkages. (nature.com)
  • Our data suggest that positive selection is inefficient at the level of the individual host and that stochastic processes dominate the host-level evolution of influenza viruses. (elifesciences.org)
  • Viruses whose host is Bacillus. (lookformedical.com)
  • Viruses whose host is Escherichia coli. (lookformedical.com)
  • Viruses whose host is Staphylococcus. (lookformedical.com)
  • A temperate coliphage, in the genus Mu-like viruses, family MYOVIRIDAE, composed of a linear, double-stranded molecule of DNA, which is able to insert itself randomly at any point on the host chromosome. (lookformedical.com)
  • Viruses are thought to be functionally inactive once they are outside and independent of their host cell1. (acguanacaste.ac.cr)
  • To gain insight into LECA biology and eukaryogenesis-the origin of the eukaryotic cell, which remains poorly understood-we reconstructed the LECA virus repertoire. (nih.gov)
  • Viruses have played a central role in the evolution and ecology of cellular life since it first arose. (montana.edu)
  • Two research articles from the ISMB RNAP laboratory published back-to-back in Nature Communications explore and characterise the global control of the archaeal RNAP in two different scenarios. (lon.ac.uk)
  • Virions of Aeropyrum pernix ovoid virus 1 (A and B) and Sulfolobus newzealandicus droplet-shaped virus (C). Virions were negatively stained (A, C) and embedded in ice (B). Scale bars, 100 nm. (ictv.global)
  • The evolutionary dynamics of influenza virus ultimately derive from processes that take place within and between infected individuals. (elifesciences.org)
  • This pseudo-glycoprotein demonstrated a high affinity for hemagglutinin/neuraminidase as well as for the drug-resistant NA mutation on the influenza virus surface due to the cluster effect. (bvsalud.org)
  • The study of the evolution of viruses is a key task for biomedical researchers. (nih.gov)
  • A temperate inducible phage and type species of the genus lambda-like viruses, in the family SIPHOVIRIDAE. (lookformedical.com)
  • Aeropyrum pernix ovoid virus 1 was isolated from Aeropyrum pernix strain K1, which was discovered in a coastal solfataric vent at Kodakara-Jima Island, Japan. (ictv.global)
  • In both cases, we found that the ancestral viromes were already highly complex and diverse including representatives from most of the major groups of extant viruses. (springernature.com)
  • 3. Modes of action of the archaeal Mre11/Rad50 DNA-repair complex revealed by fast-scan atomic force microscopy. (nih.gov)
  • 8. Post-translational methylations of the archaeal Mre11:Rad50 complex throughout the DNA damage response. (nih.gov)