A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.
Habitual moderation in the indulgence of a natural appetite, especially but not exclusively the consumption of alcohol.
Child with one or more parents afflicted by a physical or mental disorder.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts research focused on improving the treatment and prevention of alcoholism and alcohol-related problems to reduce the health, social, and economic consequences of this disease. NIAAA, NIMH, and NIDA were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.
Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).
Persons who have a history of physical or psychological dependence on ETHANOL.
Acute and chronic neurologic disorders associated with the various neurologic effects of ETHANOL. Primary sites of injury include the brain and peripheral nerves.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
A late-appearing component of the event-related potential. P300 stands for a positive deflection in the event-related voltage potential at 300 millisecond poststimulus. Its amplitude increases with unpredictable, unlikely, or highly significant stimuli and thereby constitutes an index of mental activity. (From Campbell, Psychiatric Dictionary, 6th ed)
An organization of self-proclaimed alcoholics who meet frequently to reinforce their practice of abstinence.
An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)
A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)
The observable, measurable, and often pathological activity of an organism that portrays its inability to overcome a habit resulting in an insatiable craving for a substance or for performing certain acts. The addictive behavior includes the emotional and physical overdependence on the object of habit in increasing amount or frequency.
An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)
A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.
A condition where seizures occur in association with ethanol abuse (ALCOHOLISM) without other identifiable causes. Seizures usually occur within the first 6-48 hours after the cessation of alcohol intake, but may occur during periods of alcohol intoxication. Single generalized tonic-clonic motor seizures are the most common subtype, however, STATUS EPILEPTICUS may occur. (Adams et al., Principles of Neurology, 6th ed, p1174)
Disorders related to or resulting from abuse or mis-use of alcohol.
Disorders stemming from the misuse and abuse of alcohol.
A form of psychotherapy involving the husband and wife and directed to improving the marital relationship.
Interaction between the father and the child.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
I'm sorry for any confusion, but the term "Oklahoma" is a geographical location and not a medical condition or term, therefore it doesn't have a medical definition. It is a state in the South Central region of the United States.
Disorders related to substance abuse.
A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)
An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus.
A condition characterized by the growth of unencapsulated masses of ADIPOSE TISSUE symmetrically deposited around the neck, shoulders, or other sites around the body.
The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Male parents, human or animal.
A disease due to deficiency of NIACIN, a B-complex vitamin, or its precursor TRYPTOPHAN. It is characterized by scaly DERMATITIS which is often associated with DIARRHEA and DEMENTIA (the three D's).
Agents inhibiting the effect of narcotics on the central nervous system.
A social group consisting of parents or parent substitutes and children.
A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids.
A personality inventory consisting of statements to be asserted or denied by the individual. The patterns of response are characteristic of certain personality attributes.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The comparative and theoretical study of culture, often synonymous with cultural anthropology.
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to substance abuse and mental health. It is commonly referred to by the acronym SAMHSA. On 1 October 1992, the United States Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA) became SAMHSA.
Drinkable liquids containing ETHANOL.
A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to health and human services.
Anxiety disorders manifested by the development of characteristic symptoms following a psychologically traumatic event that is outside the normal range of usual human experience. Symptoms include re-experiencing the traumatic event, increased arousal, and numbing of responsiveness to or reduced involvement with the external world. Traumatic stress disorders can be further classified by the time of onset and the duration of these symptoms.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).
5-Hydroxy-indole-3-ethanol.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
Ethnic group originating in India and entering Europe in the 14th or 15th century.
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
Brain waves seen on EEG characterized by a high amplitude and a frequency of 4 Hz and below. They are considered the "deep sleep waves" observed during sleep in dreamless states, infancy, and in some brain disorders.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."
Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
In current usage, approximately equivalent to personality. The sum of the relatively fixed personality traits and habitual modes of response of an individual.
The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)
A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)
Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.

Lymphocyte proliferation inhibitory factor (PIF) in alcoholic liver disease. (1/5630)

Lymphocyte proliferation inhibitory factor (PIF) was determined in the supernatants of PHA-stimulated lymphocytes from patients with alcoholic liver disease. PIF was assayed by determining inhibition of DNA synthesis in WI-38 human lung fibroblasts. A two-fold greater inhibition in thymidine incorporation into DNA by lung fibroblasts was observed in supernatants of PHA stimulated lymphocytes from patients with alcoholic hepatitis or active Laennec's cirrhosis as compared with that found in control subjects or patients with fatty liver. It is suggested that decreased liver cell regeneration seen in some patients with alcoholic hepatitis may be due to increased elaboration of PIF.  (+info)

Antibodies against phospholipids and oxidized LDL in alcoholic patients. (2/5630)

Antiphospholipid antibodies (APA) are a generic term describing antibodies that recognize various phospholipids. Hepatocyte damage is a cardinal event in the course of alcoholic liver injury and autoantibodies against phospholipids could play an important role in this process. APA in alcoholic patients seem to reflect membrane lesions, impairment of immunological reactivity, liver disease progression and they correlate significantly with disease severity. LDL oxidation is supposed to be one of the most important pathogenic mechanisms of atherosclerosis and antibodies against oxidized low-density lipoprotein (oxLDL) are some kind of an epiphenomenon of this process. The scope of our study was to determine some autoantibodies (IgG-oxLDL and antiphospholipid antibodies) and their possible changes in alcoholic patients. We studied IgG-oxLDL and four APA - anticardiolipin antibodies (ACA), antiphosphatidylserine antibodies (APSA) antiphosphatidylethanolamine antibodies (APE) and antiphosphatidylcholine antibodies (APCA) in 35 alcoholic patients with mildly affected liver function at the beginning of the abuse treatment. The control group consisted of 60 healthy blood donors. In the studied group, we obtained positive results concerning total ACA in 17.1 % of alcoholic patients (8.3 % in the control group), 11.4 % IgG-ACA (6.7 %), 8.6 % IgM-ACA (3.3 %), 14.3 % total APE (6.7 %), 14.3 % total APCA (8.3 %) and 20 % total APSA (8.3 % in the control group). The IgG-oxLDL (406.4+/-52.5 vs 499.9+/-52.5 mU/ml) was not affected in alcoholic patients. We conclude that the autoantibodies against oxLDL are present in sera of alcoholics and healthy blood donors. Based on our results which revealed a wide range of IgG-oxLDL titres in the healthy population, this parameter does not appear to be very promising for the evaluation of the risk of atherosclerosis. Alcoholics with only mild affection of liver functions did not exhibit a significantly higher prevalence of all studied antiphospholipid antibodies (ACA, APSA, APE, APCA) which could lead to membrane lesions in these patients.  (+info)

Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. (3/5630)

Hydroxylation of salicylate into 2,3 and 2,5-dihydroxybenzoic acids (2,3-DHBA and 2,5-DHBA) by human liver microsomal preparations was investigated. Kinetic studies demonstrated that salicylate was 5-hydroxylated with two apparent Km: one high-affinity Km of 606 microM and one low-affinity Km greater than 2 mM. Liver microsomes prepared from 15 human samples catalyzed the formation of 2,5-DHBA at metabolic rate of 21.7 +/- 8.5 pmol/mg/min. The formation of 2, 3-DHBA was not P-450 dependent. Formation of 2,5-DHBA was inhibited by 36 +/- 14% following preincubation of microsomes with diethyldithiocarbamate, a mechanism-based selective inhibitor of P-450 2E1. Furthermore, the efficiency of inhibition was significantly correlated with four catalytic activities specific to P-450 2E1, whereas the residual activity was correlated with three P-450 3A4 catalytic activities. Troleandomycin, a mechanism-based inhibitor selective to P-450 3A4, inhibited by 30 +/- 12% the 5-hydroxylation of salicylate, and this inhibition was significantly correlated with nifedipine oxidation, specific to P-450 3A4. The capability of seven recombinant human P-450s to hydroxylate salicylate demonstrated that P-450 2E1 and 3A4 contributed to 2, 5-DHBA formation in approximately equal proportions. The Km values of recombinant P-450 2E1 and 3A4, 280 and 513 microM, respectively, are in the same range as the high-affinity Km measured with human liver microsomes. The plasmatic metabolic ratio 2,5-DHBA/salicylate, measured 2 h after ingestion of 1 g acetylsalicylate, was increased 3-fold in 12 alcoholic patients at the beginning of their withdrawal period versus 15 control subjects. These results confirm that P-450 2E1, inducible by ethanol, is involved in the 5-hydroxylation of salicylate in humans. Furthermore, this ratio was still increased by 2-fold 1 week after ethanol withdrawal. This finding suggests that P-450 3A4, known to be also inducible by alcoholic beverages, plays an important role in this increase, because P-450 2E1 returned to normal levels in less than 3 days after ethanol withdrawal. Finally, in vivo and in vitro data demonstrated that P-450 2E1 and P-450 3A4, both inducible by alcohols, catalyzed the 5-hydroxylation of salicylate.  (+info)

The role of gamma-hydroxybutyric acid in the treatment of alcoholism: from animal to clinical studies. (4/5630)

Since its discovery nearly 40 years ago, gamma-hydroxybutyric acid (GHB) has attracted several waves of scientific interest due to new developments in the knowledge of its mechanisms of action and ideas for its potential use in clinical practice. Its effects have been claimed to treat different psychiatric conditions, but over time its use has become limited to a few specific situations (e.g. sedating patients in non-painful surgical procedures and narcolepsy). New interest in the drug derives from its potential use in the treatment of alcoholism. Recent studies demonstrated a marked effect of the substance in suppressing ethanol (ETOH) withdrawal symptoms and in reducing craving for alcohol, compared to other available drugs. However, GHB has to be given under very careful supervision because of its side-effects, including the risk of abuse and dependence and possible interference with the metabolic pathways of endogenous GHB and ETOH. This short review discusses these and related issues and we hope that it will stimulate further interest in GHB.  (+info)

The impact of Alcohol and Alcoholism among substance abuse journals. (5/5630)

This article concerns the question of journal impact factor and other bibliometric indicators made available by the Institute for Scientific Information in their Journal Citation Report for 1996. The impact factors of journals within the subject category 'substance abuse' are listed along with total citations, immediacy indices, and cited half-lives. The relationship between cited and citing journals is discussed with the main focus on the data available for Alcohol and Alcoholism. Some of the problems and limitations of bibliometric measures of productivity are dealt with, especially when these are used to evaluate the work of individual scientists. Although bibliometric measures are easy to compute, they become difficult to interpret, such as when dealing with collaborative research and the problem posed by multiple authorship. The need to adjust impact factors and citation counts for the number of co-authors in a paper becomes important when credit has to be attributed to one individual from a multi-author paper. This is often necessary in connection with grant applications and when making decisions about academic promotion and tenure. The impact factor of Alcohol and Alcoholism has increased steadily over the past 5 years, even after adjusting for the number of self-citations, which resulted in an even greater increase in impact. However, the impact factors of substance abuse journals are generally low, compared with disciplines such as immunology, genetics, and biochemistry. Some suggestions are made for increasing the impact factors of substance abuse journals if this is considered necessary. But instead of paying attention to the impact factor of a journal, scientists should give more consideration to the speed and efficiency of the editorial handling of their manuscripts and particularly to the quality and timeliness of the peer review.  (+info)

Enhancing the identification of excessive drinkers on medical wards: a 1-year follow-up study. (6/5630)

This paper describes a 1-year follow-up study examining whether hospital ward doctors and nurses continue to take quantitative alcohol histories and provide brief intervention to problem drinkers on general medical wards after the introduction of a simple protocol. Regular training in the use of this protocol was stipulated in the annual service contract between the Health Authority and the Hospital Trusts. Improvements in staff practice persisted at 1-year follow-up, although it fell from a peak at an earlier phase of the study. The positive role of state purchasers of health services in sustaining improvements in clinical practice is discussed.  (+info)

Urban-rural comparisons of drink-driving behaviour among late teens: a preliminary investigation. (7/5630)

A preliminary study was conducted to examine the nature and extent of urban-rural differences in self-reported drinking and driving among youths in Western Australia. A total of 102 youths aged 17, 18 and 19 years were surveyed via a random street sampling technique about their alcohol consumption and drink-driving behaviour. Analyses indicated that urban youths had a significantly higher level of self-reported drink-driving behaviour than their rural counterparts. Males indicated a higher level of self-reported drink-driving behaviour than females. This article also provides a review and summary of youth drink-driving literature with special focus on urban-rural comparisons.  (+info)

Alcohol consumption profile by time in middle-aged men: a longitudinal study based on three different diagnostic instruments. (8/5630)

This longitudinal study aimed at comparing aggregate measures of heavy or problem drinking and their variations across time among the same subjects. We examined middle-aged men participating in a health survey over a 5-year interval. Of the 133 consecutive men in the whole age group interviewed as 40-year-olds in 1989, 114 were reached and re-interviewed in 1994. Alcohol consumption was measured by self-report, Malmo-modified Michigan Alcoholism Screening Test (Mm-MAST), and serum carbohydrate-deficient transferrin (CDT). Self-reported alcohol consumption decreased with years (142 vs 105 g/week, P = 0.01), as did CDT (16.9 vs 14.4 U/l, P = 0.02), but there was no change in the Mm-MAST results. There was no significant difference in the number of heavy drinkers (either Mm-MAST score > or = 3, or by self-reported alcohol consumption > or = 280 g/week, or by CDT > or = 20 U/l) at 40 and 45 years of age (37 and 47% respectively). At the individual level, alcohol consumption both increased and decreased with age. At 45 years of age 5/114 (4%) of the men reported that they had increased their alcohol consumption by more than 80 g/week and 25/114 (22%) said that they had reduced their drinking by the same amount. The remaining 84 (74%) reported drinking the same amount as 5 years earlier (+/- 80 g/week). This indicates that alcohol drinking habits are not stable in middle age. Most heavy drinkers in both age groups were detected by Mm-MAST and this proportion increased with age while the proportion of positive self-reports and CDTs decreased. Thus, the social consequences, measured here by the Mm-MAST, may be more readily experienced with years even at smaller consumption levels.  (+info)

Alcoholism is a chronic and often relapsing brain disorder characterized by the excessive and compulsive consumption of alcohol despite negative consequences to one's health, relationships, and daily life. It is also commonly referred to as alcohol use disorder (AUD) or alcohol dependence.

The diagnostic criteria for AUD include a pattern of alcohol use that includes problems controlling intake, continued use despite problems resulting from drinking, development of a tolerance, drinking that leads to risky behaviors or situations, and withdrawal symptoms when not drinking.

Alcoholism can cause a wide range of physical and psychological health problems, including liver disease, heart disease, neurological damage, mental health disorders, and increased risk of accidents and injuries. Treatment for alcoholism typically involves a combination of behavioral therapies, medications, and support groups to help individuals achieve and maintain sobriety.

Ethanol is the medical term for pure alcohol, which is a colorless, clear, volatile, flammable liquid with a characteristic odor and burning taste. It is the type of alcohol that is found in alcoholic beverages and is produced by the fermentation of sugars by yeasts.

In the medical field, ethanol is used as an antiseptic and disinfectant, and it is also used as a solvent for various medicinal preparations. It has central nervous system depressant properties and is sometimes used as a sedative or to induce sleep. However, excessive consumption of ethanol can lead to alcohol intoxication, which can cause a range of negative health effects, including impaired judgment, coordination, and memory, as well as an increased risk of accidents, injuries, and chronic diseases such as liver disease and addiction.

Alcohol deterrents, also known as alcohol deterrent devices or ignition interlock devices, are breathalyzer devices that are installed in vehicles to prevent a driver from starting the vehicle if their blood alcohol concentration (BAC) is above a certain limit. These devices are often used as a condition of license reinstatement for individuals who have been convicted of drunk driving or other alcohol-related offenses.

The driver must blow into the device, and if their BAC is above the programmed limit, the vehicle will not start. Some devices also require periodic rolling retests while the vehicle is in motion to ensure that the driver remains sober throughout the trip. The use of alcohol deterrents has been shown to reduce recidivism rates among drunk drivers and improve overall road safety.

In the context of medicine and health, "temperance" refers to moderation or self-restraint in the consumption of potentially harmful substances, particularly alcohol. It promotes a balanced lifestyle that avoids excessive habits, such as overeating, substance abuse, or any other activities that could negatively impact one's health.

However, it is important to note that "temperance" itself is not a medical term per se but has been used in various historical and social contexts related to health promotion and disease prevention.

There is no formal medical definition for "child of impaired parents." However, it generally refers to a child who has at least one parent with physical, mental, or psychological challenges that impact their ability to care for themselves and/or their children. These impairments may include substance abuse disorders, mental illnesses, chronic medical conditions, or developmental disabilities.

Children of impaired parents often face unique challenges and stressors in their lives, which can affect their emotional, social, and cognitive development. They may have to take on additional responsibilities at home, experience neglect or abuse, or witness disturbing behaviors related to their parent's impairment. As a result, these children are at higher risk for developing mental health issues, behavioral problems, and academic difficulties.

Support services and interventions, such as family therapy, counseling, and community resources, can help mitigate the negative effects of growing up with impaired parents and improve outcomes for these children.

'Alcohol drinking' refers to the consumption of alcoholic beverages, which contain ethanol (ethyl alcohol) as the active ingredient. Ethanol is a central nervous system depressant that can cause euphoria, disinhibition, and sedation when consumed in small to moderate amounts. However, excessive drinking can lead to alcohol intoxication, with symptoms ranging from slurred speech and impaired coordination to coma and death.

Alcohol is metabolized in the liver by enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). The breakdown of ethanol produces acetaldehyde, a toxic compound that can cause damage to various organs in the body. Chronic alcohol drinking can lead to a range of health problems, including liver disease, pancreatitis, cardiovascular disease, neurological disorders, and increased risk of cancer.

Moderate drinking is generally defined as up to one drink per day for women and up to two drinks per day for men, where a standard drink contains about 14 grams (0.6 ounces) of pure alcohol. However, it's important to note that there are no safe levels of alcohol consumption, and any level of drinking carries some risk to health.

Central Nervous System (CNS) depressants are a class of drugs that slow down the activity of the CNS, leading to decreased arousal and decreased level of consciousness. They work by increasing the inhibitory effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, which results in sedation, relaxation, reduced anxiety, and in some cases, respiratory depression.

Examples of CNS depressants include benzodiazepines, barbiturates, non-benzodiazepine hypnotics, and certain types of pain medications such as opioids. These drugs are often used medically to treat conditions such as anxiety, insomnia, seizures, and chronic pain, but they can also be misused or abused for their sedative effects.

It is important to use CNS depressants only under the supervision of a healthcare provider, as they can have serious side effects, including addiction, tolerance, and withdrawal symptoms. Overdose of CNS depressants can lead to coma, respiratory failure, and even death.

Alcoholism, also known as alcohol use disorder (AUD), is a chronic relapsing brain disorder characterized by an impaired ability to stop or control alcohol consumption despite adverse social, occupational, or health consequences. It is defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) as a problematic pattern of alcohol use leading to clinically significant impairment or distress, as manifested by at least two of the following, occurring within a 12-month period:

1. Alcohol is often taken in larger amounts or over a longer period than was intended.
2. There is a persistent desire or unsuccessful efforts to cut down or control alcohol use.
3. A great deal of time is spent in activities necessary to obtain, use, or recover from the effects of alcohol.
4. Craving, or a strong desire or urge to use alcohol, is present.
5. Recurrent alcohol use results in a failure to fulfill major role obligations at work, school, or home.
6. Alcohol use continues despite having persistent or recurrent social or interpersonal problems caused or exacerbated by the effects of alcohol.
7. Important social, occupational, or recreational activities are given up or reduced because of alcohol use.
8. Recurrent alcohol use is in situations in which it is physically hazardous.
9. Alcohol use is continued despite knowledge of having a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by alcohol.
10. Tolerance, as defined by either of the following:
a) A need for markedly increased amounts of alcohol to achieve intoxication or desired effect.
b) A markedly diminished effect with continued use of the same amount of alcohol.
11. Withdrawal, as manifested by either of the following:
a) The characteristic withdrawal syndrome for alcohol (refer to DSM-5 for further details).
b) Alcohol (or a closely related substance, such as a benzodiazepine) is taken to relieve or avoid withdrawal symptoms.

The severity of alcohol use disorder is classified as mild, moderate, or severe based on the number of criteria met:

* Mild: 2-3 criteria met
* Moderate: 4-5 criteria met
* Severe: 6 or more criteria met

It's important to note that alcohol use disorder is a complex condition with various factors contributing to its development and course. If you or someone you know is struggling with alcohol use, it's crucial to seek professional help from a healthcare provider or a mental health specialist for an accurate assessment and appropriate treatment.

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), alcohol-induced disorders of the nervous system are a category of conditions characterized by symptoms that are directly caused by alcohol use or withdrawal. These disorders include:

1. Alcohol-induced neurocognitive disorder: This condition is characterized by significant impairment in cognitive functioning, including difficulties with attention, memory, and executive functions, which are caused by alcohol use or withdrawal.
2. Alcohol-induced mood disorder: This condition is characterized by the presence of a mood disorder, such as depression or mania, that is directly caused by alcohol use or withdrawal.
3. Alcohol-induced anxiety disorder: This condition is characterized by the presence of an anxiety disorder, such as panic disorder or social anxiety disorder, that is directly caused by alcohol use or withdrawal.
4. Alcohol-induced sleep disorder: This condition is characterized by difficulty sleeping or maintaining sleep that is directly caused by alcohol use or withdrawal.
5. Alcohol-induced sexual dysfunction: This condition is characterized by the presence of sexual dysfunction, such as erectile dysfunction or decreased libido, that is directly caused by alcohol use or withdrawal.
6. Alcohol-induced movement disorder: This condition is characterized by the presence of abnormal movements, such as tremors or ataxia, that are directly caused by alcohol use or withdrawal.

It's important to note that in order for a diagnosis of an alcohol-induced disorder to be made, the symptoms must be severe enough to cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. Additionally, the symptoms must not be better explained by another medical condition or mental disorder.

Disulfiram is a medication used to treat chronic alcoholism. It works by inhibiting the enzyme acetaldehyde dehydrogenase, which is responsible for breaking down acetaldehyde, a toxic metabolite produced when alcohol is consumed. When a person taking disulfiram consumes alcohol, the buildup of acetaldehyde causes unpleasant symptoms such as flushing, nausea, palpitations, and shortness of breath, which can help discourage further alcohol use.

The medical definition of Disulfiram is:

A medication used in the treatment of chronic alcoholism, which works by inhibiting the enzyme acetaldehyde dehydrogenase, leading to an accumulation of acetaldehyde when alcohol is consumed, causing unpleasant symptoms that discourage further alcohol use. Disulfiram is available as a tablet for oral administration and is typically prescribed under medical supervision due to its potential for serious interactions with alcohol and other substances.

Naltrexone is a medication that is primarily used to manage alcohol dependence and opioid dependence. It works by blocking the effects of opioids and alcohol on the brain, reducing the euphoric feelings and cravings associated with their use. Naltrexone comes in the form of a tablet that is taken orally, and it has no potential for abuse or dependence.

Medically, naltrexone is classified as an opioid antagonist, which means that it binds to opioid receptors in the brain without activating them, thereby blocking the effects of opioids such as heroin, morphine, and oxycodone. It also reduces the rewarding effects of alcohol by blocking the release of endorphins, which are natural chemicals in the brain that produce feelings of pleasure.

Naltrexone is often used as part of a comprehensive treatment program for addiction, along with counseling, behavioral therapy, and support groups. It can help individuals maintain abstinence from opioids or alcohol by reducing cravings and preventing relapse. Naltrexone is generally safe and well-tolerated, but it may cause side effects such as nausea, headache, dizziness, and fatigue in some people.

It's important to note that naltrexone should only be used under the supervision of a healthcare provider, and it is not recommended for individuals who are currently taking opioids or who have recently stopped using them, as it can cause withdrawal symptoms. Additionally, naltrexone may interact with other medications, so it's important to inform your healthcare provider of all medications you are taking before starting naltrexone therapy.

Alcoholic intoxication, also known as alcohol poisoning, is a condition that occurs when a person consumes a large amount of alcohol in a short period of time. This can lead to an increase in the concentration of alcohol in the blood, which can affect the normal functioning of the body's organs and systems.

The symptoms of alcoholic intoxication can vary depending on the severity of the condition, but they may include:

* Confusion or disorientation
* Slurred speech
* Poor coordination
* Staggering or difficulty walking
* Vomiting
* Seizures
* Slow or irregular breathing
* Low body temperature (hypothermia)
* Pale or blue-tinged skin
* Unconsciousness or coma

Alcoholic intoxication can be a medical emergency and requires immediate treatment. If you suspect that someone has alcohol poisoning, it is important to seek medical help right away. Treatment may include supportive care, such as providing fluids and oxygen, and monitoring the person's vital signs. In severe cases, hospitalization may be necessary.

It is important to note that alcoholic intoxication can occur even at relatively low levels of alcohol consumption, especially in people who are not used to drinking or who have certain medical conditions. It is always best to drink in moderation and to be aware of the potential risks associated with alcohol consumption.

Alcoholic Liver Cirrhosis is a medical condition characterized by irreversible scarring (fibrosis) and damage to the liver caused by excessive consumption of alcohol over an extended period. The liver's normal structure and function are progressively impaired as healthy liver tissue is replaced by scarred tissue, leading to the formation of nodules (regenerative noduli).

The condition typically develops after years of heavy drinking, with a higher risk for those who consume more than 60 grams of pure alcohol daily. The damage caused by alcoholic liver cirrhosis can be life-threatening and may result in complications such as:

1. Ascites (accumulation of fluid in the abdomen)
2. Encephalopathy (neurological dysfunction due to liver failure)
3. Esophageal varices (dilated veins in the esophagus that can rupture and bleed)
4. Hepatorenal syndrome (kidney failure caused by liver disease)
5. Increased susceptibility to infections
6. Liver cancer (hepatocellular carcinoma)
7. Portal hypertension (increased blood pressure in the portal vein that supplies blood to the liver)

Abstaining from alcohol and managing underlying medical conditions are crucial for slowing down or halting disease progression. Treatment may involve medications, dietary changes, and supportive care to address complications. In severe cases, a liver transplant might be necessary.

Event-Related Potentials (ERPs) are brain responses that are directly related to a specific sensory, cognitive, or motor event. P300 is a positive deflection in the ERP waveform that occurs approximately 300 milliseconds after the onset of a rare or unexpected stimulus. It is often used as an index of cognitive processes such as attention, memory, and decision-making. The amplitude of the P300 component is typically larger for targets than for non-targets, and it is thought to reflect the amount of attentional resources allocated to the processing of the stimulus. Additionally, the latency of the P300 component can be used as an indicator of the speed of cognitive processing.

It's important to note that ERPs are measured using electroencephalography (EEG) and it requires averaging multiple trials to extract the signal from the noise. Also, P300 is just one component of ERP, there are other components like N100, P100, N200 etc which also have their own significance in understanding the cognitive processes.

Alcoholics Anonymous (AA) is a international fellowship of individuals who have had a drinking problem and wish to do something about it. AA is nonprofessional, self-supporting, multiracial, apolitical, and available almost everywhere. There are no age or education requirements, and membership is open to anyone who wants to do something about their drinking problem.

AA's primary purpose is to help alcoholics stop drinking, though the organization also aims to inspire personal growth and improve the quality of life for its members. AA's program of recovery is based on the Twelve Steps, a set of principles that, when practiced as a way of life, can expel the obsession to drink and enable the sufferer to become happily and usefully whole.

The organization holds regular meetings where members share their experiences, strength, and hope to help one another recover from alcoholism. AA also offers sponsorship, where more experienced members work with newer members to guide them through the Twelve Step program.

It's important to note that while AA has helped many people achieve and maintain sobriety, it is not the only path to recovery from alcoholism. Other evidence-based treatments, such as medication-assisted treatment and behavioral therapy, are also effective for some individuals.

Alcohol withdrawal delirium, also known as delirium tremens (DTs), is a serious and potentially life-threatening complication that can occur in people who are dependent on alcohol and suddenly stop or significantly reduce their consumption. It is a form of alcohol withdrawal syndrome that is characterized by the sudden onset of severe confusion, agitation, hallucinations, tremors, and autonomic hyperactivity.

The diagnostic criteria for alcohol withdrawal delirium, as outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), include:

1. Disturbance in consciousness (i.e., reduced clarity of awareness of the environment) with reduced ability to focus, sustain, or shift attention.
2. A change in cognition (such as memory deficit, disorientation, or language disturbance) or the development of a perceptual disturbance that is not better explained by another medical condition or substance use disorder.
3. The disturbance develops over a short period of time (usually hours to a few days) and tends to fluctuate throughout the day.
4. There is evidence from the history, physical examination, or laboratory findings that the symptoms are caused by alcohol withdrawal.
5. The symptoms cannot be better explained by another medical condition, medication use, or substance intoxication or withdrawal.

Alcohol withdrawal delirium is a medical emergency and requires immediate treatment in a hospital setting. Treatment typically involves the use of medications to manage symptoms, such as benzodiazepines to reduce agitation and prevent seizures, and antipsychotic medications to treat hallucinations and delusions. Supportive care, such as fluid and electrolyte replacement, may also be necessary to prevent dehydration and other complications.

Antisocial Personality Disorder (ASPD) is a mental health condition characterized by a pervasive pattern of disregard for the rights of others, lack of empathy, and manipulative behaviors. It is defined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), as follows:

A. A consistent pattern of behavior that violates the basic rights of others and major age-appropriate societal norms and rules, as indicated by the presence of at least three of the following:

1. Failure to conform to social norms and laws, indicated by repeatedly performing acts that are grounds for arrest.
2. Deceitfulness, as indicated by repeated lying, use of aliases, or conning others for personal profit or pleasure.
3. Impulsivity or failure to plan ahead; indication of this symptom may include promiscuity.
4. Irritability and aggressiveness, as indicated by repeated physical fights or assaults.
5. Reckless disregard for safety of self or others.
6. Consistent irresponsibility, as indicated by repeated failure to sustain consistent work behavior or honor financial obligations.
7. Lack of remorse, as indicated by being indifferent to or rationalizing having hurt, mistreated, or stolen from another.

B. The individual is at least 18 years of age.

C. There is evidence of conduct disorder with onset before the age of 15 years.

D. The occurrence of antisocial behavior is not exclusively during the course of schizophrenia or bipolar disorder.

E. The individual's criminal behavior has not been better explained by a conduct disorder diagnosis or antisocial behavior that began before the age of 15 years.

It's important to note that ASPD can be challenging to diagnose, and it often requires a comprehensive evaluation from a mental health professional with experience in personality disorders.

Addictive behavior is a pattern of repeated self-destructive behavior, often identified by the individual's inability to stop despite negative consequences. It can involve a variety of actions such as substance abuse (e.g., alcohol, drugs), gambling, sex, shopping, or using technology (e.g., internet, social media, video games).

These behaviors activate the brain's reward system, leading to feelings of pleasure and satisfaction. Over time, the individual may require more of the behavior to achieve the same level of pleasure, resulting in tolerance. If the behavior is stopped or reduced, withdrawal symptoms may occur.

Addictive behaviors can have serious consequences on an individual's physical, emotional, social, and financial well-being. They are often associated with mental health disorders such as depression, anxiety, and bipolar disorder. Treatment typically involves a combination of behavioral therapy, medication, and support groups to help the individual overcome the addiction and develop healthy coping mechanisms.

Aldehyde dehydrogenase (ALDH) is a class of enzymes that play a crucial role in the metabolism of alcohol and other aldehydes in the body. These enzymes catalyze the oxidation of aldehydes to carboxylic acids, using nicotinamide adenine dinucleotide (NAD+) as a cofactor.

There are several isoforms of ALDH found in different tissues throughout the body, with varying substrate specificities and kinetic properties. The most well-known function of ALDH is its role in alcohol metabolism, where it converts the toxic aldehyde intermediate acetaldehyde to acetate, which can then be further metabolized or excreted.

Deficiencies in ALDH activity have been linked to a number of clinical conditions, including alcohol flush reaction, alcohol-induced liver disease, and certain types of cancer. Additionally, increased ALDH activity has been associated with chemotherapy resistance in some cancer cells.

Alcohol dehydrogenase (ADH) is a group of enzymes responsible for catalyzing the oxidation of alcohols to aldehydes or ketones, and reducing equivalents such as NAD+ to NADH. In humans, ADH plays a crucial role in the metabolism of ethanol, converting it into acetaldehyde, which is then further metabolized by aldehyde dehydrogenase (ALDH) into acetate. This process helps to detoxify and eliminate ethanol from the body. Additionally, ADH enzymes are also involved in the metabolism of other alcohols, such as methanol and ethylene glycol, which can be toxic if allowed to accumulate in the body.

Substance Withdrawal Syndrome is a medically recognized condition that occurs when an individual who has been using certain substances, such as alcohol, opioids, or benzodiazepines, suddenly stops or significantly reduces their use. The syndrome is characterized by a specific set of symptoms that can be physical, cognitive, and emotional in nature. These symptoms can vary widely depending on the substance that was being used, the length and intensity of the addiction, and individual factors such as genetics, age, and overall health.

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), published by the American Psychiatric Association, provides the following diagnostic criteria for Substance Withdrawal Syndrome:

A. The development of objective evidence of withdrawal, referring to the specific physiological changes associated with the particular substance, or subjective evidence of withdrawal, characterized by the individual's report of symptoms that correspond to the typical withdrawal syndrome for the substance.

B. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.

C. The symptoms are not better explained by co-occurring mental, medical, or other substance use disorders.

D. The withdrawal syndrome is not attributable to another medical condition and is not better accounted for by another mental disorder.

The DSM-5 also specifies that the diagnosis of Substance Withdrawal Syndrome should be substance-specific, meaning that it should specify the particular class of substances (e.g., alcohol, opioids, benzodiazepines) responsible for the withdrawal symptoms. This is important because different substances have distinct withdrawal syndromes and require different approaches to management and treatment.

In general, Substance Withdrawal Syndrome can be a challenging and potentially dangerous condition that requires professional medical supervision and support during the detoxification process. The specific symptoms and their severity will vary depending on the substance involved, but they may include:

* For alcohol: tremors, seizures, hallucinations, agitation, anxiety, nausea, vomiting, and insomnia.
* For opioids: muscle aches, restlessness, lacrimation (tearing), rhinorrhea (runny nose), yawning, perspiration, chills, mydriasis (dilated pupils), piloerection (goosebumps), nausea or vomiting, diarrhea, and abdominal cramps.
* For benzodiazepines: anxiety, irritability, insomnia, restlessness, confusion, hallucinations, seizures, and increased heart rate and blood pressure.

It is essential to consult with a healthcare professional if you or someone you know is experiencing symptoms of Substance Withdrawal Syndrome. They can provide appropriate medical care, support, and referrals for further treatment as needed.

Alcohol Amnestic Disorder is not listed as a separate disorder in the current edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which is used by mental health professionals to diagnose mental conditions. However, it was previously included in earlier editions as a subtype of Amnestic Disorder due to the effects of substance use or exposure to toxins.

Alcohol Amnestic Disorder is characterized by significant memory impairment that is directly caused by alcohol consumption. This disorder can result in anterograde amnesia, which is the inability to form new memories after drinking, and/or retrograde amnesia, which involves forgetting previously learned information or personal experiences.

The diagnosis of Alcohol Amnestic Disorder typically requires a comprehensive medical and neuropsychological evaluation to determine the extent and nature of memory impairment, as well as to rule out other potential causes for cognitive decline. Treatment usually involves a combination of abstinence from alcohol, pharmacotherapy, and psychosocial interventions to address substance use disorder and any co-occurring mental health conditions.

Alcoholic psychosis is a term used to describe a group of psychiatric disorders that are directly related to alcohol abuse or withdrawal. The two most common types of alcoholic psychosis are Wernicke's encephalopathy and Korsakoff's syndrome, which often occur together and are referred to as Wernicke-Korsakoff syndrome.

Wernicke's encephalopathy is a acute neurological disorder characterized by confusion, memory loss, difficulty with muscle coordination, and abnormal eye movements. It is caused by a thiamine (vitamin B1) deficiency that is often seen in people who are chronic alcoholics.

Korsakoff's syndrome, on the other hand, is a chronic memory disorder characterized by severe memory loss and confusion. People with Korsakoff's syndrome often have difficulty learning new information and may confabulate, or make up information, to fill in gaps in their memory.

Both Wernicke's encephalopathy and Korsakoff's syndrome are serious conditions that require immediate medical attention. Treatment typically involves administering thiamine and other vitamins, as well as providing supportive care to help manage symptoms. In some cases, hospitalization may be necessary.

It is important to note that alcohol abuse can also lead to other types of psychosis, such as delirium tremens (DTs), which is a severe form of alcohol withdrawal that can cause confusion, hallucinations, and seizures. If you or someone you know is struggling with alcohol abuse, it is important to seek professional help as soon as possible.

Alcohol withdrawal seizures are a type of seizure that can occur as a result of alcohol withdrawal in individuals who have developed physical dependence on alcohol. These seizures typically occur within 48 hours after the last drink, but they can sometimes happen up to five days later. They are often accompanied by other symptoms of alcohol withdrawal, such as tremors, anxiety, nausea, and increased heart rate.

Alcohol withdrawal seizures are caused by changes in the brain's chemistry that occur when a person who is dependent on alcohol suddenly stops or significantly reduces their alcohol intake. Alcohol affects the neurotransmitters in the brain, particularly gamma-aminobutyric acid (GABA) and glutamate. When a person drinks heavily and frequently, the brain adjusts to the presence of alcohol by reducing the number of GABA receptors and increasing the number of glutamate receptors.

When a person suddenly stops drinking, the brain is thrown out of balance, and the reduced number of GABA receptors and increased number of glutamate receptors can lead to seizures. Alcohol withdrawal seizures are a medical emergency and require immediate treatment to prevent complications such as status epilepticus (prolonged seizures) or brain damage. Treatment typically involves administering benzodiazepines, which help to calm the brain and reduce the risk of seizures.

According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), alcohol-related disorders are a category of mental disorders defined by a problematic pattern of alcohol use that leads to clinically significant impairment or distress. The disorders include:

1. Alcohol Use Disorder (AUD): A chronic relapsing brain disorder characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD can be mild, moderate, or severe, and recovery is possible regardless of severity. The symptoms include problems controlling intake of alcohol, continued use despite problems resulting from drinking, development of a tolerance, drinking that leads to risky situations, or withdrawal symptoms when not drinking.
2. Alcohol Intoxication: A state of acute impairment in mental and motor function caused by the recent consumption of alcohol. The symptoms include slurred speech, unsteady gait, nystagmus, impaired attention or memory, stupor, or coma. In severe cases, it can lead to respiratory depression, hypothermia, or even death.
3. Alcohol Withdrawal: A syndrome that occurs when alcohol use is heavily reduced or stopped after prolonged and heavy use. The symptoms include autonomic hyperactivity, increased hand tremor, insomnia, nausea or vomiting, transient visual, tactile, or auditory hallucinations or illusions, psychomotor agitation, anxiety, and grand mal seizures.
4. Other Alcohol-Induced Disorders: These include alcohol-induced sleep disorder, alcohol-induced sexual dysfunction, and alcohol-induced major neurocognitive disorder.

It is important to note that alcohol use disorders are complex conditions that can be influenced by a variety of factors, including genetics, environment, and personal behavior. If you or someone you know is struggling with alcohol use, it is recommended to seek professional help.

According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), alcohol-induced disorders are a category of mental disorders that are directly caused by substance/medication use. Specifically, alcohol-induced disorders refer to conditions where the primary cause is the use of alcohol or its withdrawal.

There are several types of alcohol-induced disorders, including:

1. Alcohol intoxication delirium: A state of confusion and disorientation that occurs due to excessive alcohol consumption.
2. Alcohol withdrawal delirium: A serious condition characterized by confusion, hallucinations, and tremors that can occur after a person stops drinking heavily and suddenly.
3. Alcohol-induced bipolar and related disorders: Mood disturbances that are directly caused by alcohol use or withdrawal.
4. Alcohol-induced depressive disorder: Depressive symptoms that are directly caused by alcohol use or withdrawal.
5. Alcohol-induced anxiety disorder: Anxiety symptoms that are directly caused by alcohol use or withdrawal.
6. Alcohol-induced sleep disorder: Sleep disturbances that are directly caused by alcohol use or withdrawal.
7. Alcohol-induced sexual dysfunction: Sexual problems that are directly caused by alcohol use or withdrawal.
8. Alcohol-induced major neurocognitive disorder: A severe decline in cognitive abilities, such as memory and decision-making skills, that is directly caused by alcohol use or withdrawal.

It's important to note that these disorders are distinct from alcohol use disorder (AUD), which refers to a pattern of problematic alcohol use that can lead to clinically significant impairment or distress. However, AUD can increase the risk of developing alcohol-induced disorders.

Marital therapy, also known as couples therapy, is a type of psychotherapy aimed at helping married or cohabitating partners understand and resolve their conflicts. It is a form of treatment that addresses the specific communication and relationship issues between two people who are in a committed relationship. The goal of marital therapy is to help couples develop skills and strategies to improve their relationship and better handle any future conflicts.

Marital therapy can be beneficial for couples facing a range of issues, including communication problems, financial stress, sexual difficulties, infidelity, addiction, and major life transitions. It is typically provided by licensed mental health professionals, such as psychologists, social workers, or marriage and family therapists. The therapy may involve individual sessions with each partner, as well as joint sessions with both partners together.

The specific approach used in marital therapy will depend on the training and preferences of the therapist, as well as the needs and goals of the couple. Some common approaches include cognitive-behavioral therapy, emotion-focused therapy, and the Gottman method. These approaches may involve exercises such as communication skills training, conflict resolution techniques, and trust-building activities. Ultimately, the goal of marital therapy is to help couples build a stronger, more fulfilling relationship.

I'm not a medical professional, but I can tell you that the term "Father-Child Relations" is a social science or psychological concept rather than a medical one. It generally refers to the nature and quality of the emotional, social, and behavioral relationship between a father and his child. This relationship can have significant impacts on a child's development, including their cognitive, emotional, and social growth. Factors such as involvement, communication, support, and attachment are often considered when examining father-child relations.

Genetic predisposition to disease refers to an increased susceptibility or vulnerability to develop a particular illness or condition due to inheriting specific genetic variations or mutations from one's parents. These genetic factors can make it more likely for an individual to develop a certain disease, but it does not guarantee that the person will definitely get the disease. Environmental factors, lifestyle choices, and interactions between genes also play crucial roles in determining if a genetically predisposed person will actually develop the disease. It is essential to understand that having a genetic predisposition only implies a higher risk, not an inevitable outcome.

Alcoholic liver disease (ALD) is a term that encompasses a spectrum of liver disorders caused by excessive alcohol consumption. The three main stages of ALD are:

1. Fatty Liver: This is the earliest stage of ALD, characterized by the accumulation of fat droplets within liver cells (hepatocytes). It's often reversible with abstinence from alcohol.

2. Alcoholic Hepatitis: This is a more severe form of ALD, characterized by inflammation and damage to the liver cells. It can range from mild to severe, and severe cases can lead to liver failure. Symptoms may include jaundice, abdominal pain, and fever.

3. Cirrhosis: This is the most advanced stage of ALD, characterized by widespread scarring (fibrosis) and nodular transformation of the liver. It's irreversible and can lead to complications such as liver failure, portal hypertension, and increased risk of liver cancer.

The development and progression of ALD are influenced by various factors, including the amount and duration of alcohol consumption, genetic predisposition, nutritional status, and co-existing viral hepatitis or other liver diseases. Abstaining from alcohol is the most effective way to prevent and manage ALD.

I'm sorry for any confusion, but "Oklahoma" is not a medical term or condition. It is a state in the south central region of the United States. If you have any questions about medical terminology or health-related topics, I would be happy to try and help answer them!

Substance-related disorders, as defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), refer to a group of conditions caused by the use of substances such as alcohol, drugs, or medicines. These disorders are characterized by a problematic pattern of using a substance that leads to clinically significant impairment or distress. They can be divided into two main categories: substance use disorders and substance-induced disorders. Substance use disorders involve a pattern of compulsive use despite negative consequences, while substance-induced disorders include conditions such as intoxication, withdrawal, and substance/medication-induced mental disorders. The specific diagnosis depends on the type of substance involved, the patterns of use, and the presence or absence of physiological dependence.

Acetaldehyde is a colorless, volatile, and flammable liquid with a pungent odor. It is the simplest aldehyde, with the formula CH3CHO. Acetaldehyde is an important intermediate in the metabolism of alcohol and is produced by the oxidation of ethanol by alcohol dehydrogenase. It is also a naturally occurring compound that is found in small amounts in various foods and beverages, such as fruits, vegetables, and coffee.

Acetaldehyde is a toxic substance that can cause a range of adverse health effects, including irritation of the eyes, nose, and throat, nausea, vomiting, and headaches. It has been classified as a probable human carcinogen by the International Agency for Research on Cancer (IARC). Long-term exposure to acetaldehyde has been linked to an increased risk of certain types of cancer, including cancers of the oral cavity, esophagus, and liver.

The Diagnostic and Statistical Manual of Mental Disorders (DSM) is a publication of the American Psychiatric Association (APA) that provides diagnostic criteria for mental disorders. It is widely used by mental health professionals in the United States and around the world to diagnose and classify mental health conditions.

The DSM includes detailed descriptions of symptoms, clinical examples, and specific criteria for each disorder, which are intended to facilitate accurate diagnosis and improve communication among mental health professionals. The manual is regularly updated to reflect current research and clinical practice, with the most recent edition being the DSM-5, published in 2013.

It's important to note that while the DSM is a valuable tool for mental health professionals, it is not without controversy. Some critics argue that the manual medicalizes normal human experiences and that its categories may be too broad or overlapping. Nonetheless, it remains an essential resource for clinicians, researchers, and policymakers in the field of mental health.

Impulsive behavior can be defined medically as actions performed without proper thought or consideration of the consequences, driven by immediate needs, desires, or urges. It often involves risky or inappropriate behaviors that may lead to negative outcomes. In a clinical context, impulsivity is frequently associated with certain mental health conditions such as ADHD (Attention Deficit Hyperactivity Disorder), bipolar disorder, borderline personality disorder, and some neurological conditions. It's important to note that everyone can exhibit impulsive behavior at times, but when it becomes a persistent pattern causing distress or functional impairment, it may indicate an underlying condition requiring professional assessment and treatment.

Multiple Symmetrical Lipomatosis is a rare condition characterized by the growth of multiple, symmetrical fatty tumors (lipomas) beneath the skin. These lipomas are typically slow-growing and benign, but their large number and symmetric distribution can lead to significant cosmetic concerns and, in some cases, functional impairment.

The tumors usually develop on the neck, shoulders, back, and abdomen, and they may also occur on the arms and legs. While the exact cause of Multiple Symmetrical Lipomatosis is not known, it has been associated with alcohol abuse and metabolic disorders. Treatment typically involves surgical removal of the lipomas, although this can be challenging due to their number and location. Recurrence of the tumors is also common.

"Family Health" is not a term that has a single, widely accepted medical definition. However, in the context of healthcare and public health, "family health" often refers to the physical, mental, and social well-being of all members of a family unit. It includes the assessment, promotion, and prevention of health conditions that affect individual family members as well as the family as a whole.

Family health may also encompass interventions and programs that aim to strengthen family relationships, communication, and functioning, as these factors can have a significant impact on overall health outcomes. Additionally, family health may involve addressing social determinants of health, such as poverty, housing, and access to healthcare, which can affect the health of families and communities.

Overall, family health is a holistic approach to healthcare that recognizes the importance of considering the needs and experiences of all family members in promoting and maintaining good health.

Medical Definition:

"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.

The term "Fathers" is a general term used to describe male parents or parental figures. It does not have a specific medical definition. In the context of genetics and reproduction, the father is the biological male who contributes his sperm to fertilize an egg, resulting in conception and pregnancy. However, it's important to note that there are many different types of families and parental relationships, and not all fathers are biological parents or male.

Pellagra is a nutritional disorder caused by a deficiency of niacin (vitamin B3) or tryptophan, an amino acid that the body can convert into niacin. It's characterized by the four D's: diarrhea, dermatitis, dementia, and death. The skin lesions typically appear on sun-exposed areas and are often described as "photosensitive." Other symptoms can include inflammation of the mucous membranes, mouth sores, anemia, and depression. If left untreated, pellagra can be fatal. It was once common in regions where people subsisted on corn as a staple food, as corn is low in tryptophan and contains niacin in a form that is not easily absorbed by the body. Nowadays, it's most commonly seen in alcoholics, people with malabsorption disorders, and those with severely restricted diets.

Narcotic antagonists are a class of medications that block the effects of opioids, a type of narcotic pain reliever, by binding to opioid receptors in the brain and blocking the activation of these receptors by opioids. This results in the prevention or reversal of opioid-induced effects such as respiratory depression, sedation, and euphoria. Narcotic antagonists are used for a variety of medical purposes, including the treatment of opioid overdose, the management of opioid dependence, and the prevention of opioid-induced side effects in certain clinical situations. Examples of narcotic antagonists include naloxone, naltrexone, and methylnaltrexone.

The term "family" in a medical context often refers to a group of individuals who are related by blood, marriage, or adoption and who consider themselves to be a single household. This can include spouses, parents, children, siblings, grandparents, and other extended family members. In some cases, the term may also be used more broadly to refer to any close-knit group of people who provide emotional and social support for one another, regardless of their biological or legal relationship.

In healthcare settings, understanding a patient's family dynamics can be important for providing effective care. Family members may be involved in decision-making about medical treatments, providing care and support at home, and communicating with healthcare providers. Additionally, cultural beliefs and values within families can influence health behaviors and attitudes towards medical care, making it essential for healthcare professionals to take a culturally sensitive approach when working with patients and their families.

Taurine is an organic compound that is widely distributed in animal tissues. It is a conditionally essential amino acid, meaning it can be synthesized by the human body under normal circumstances, but there may be increased requirements during certain periods such as infancy, infection, or illness. Taurine plays important roles in various physiological functions, including bile salt formation, membrane stabilization, neuromodulation, and antioxidation. It is particularly abundant in the brain, heart, retina, and skeletal muscles. In the human body, taurine is synthesized from the amino acids cysteine and methionine with the aid of vitamin B6.

Taurine can also be found in certain foods like meat, fish, and dairy products, as well as in energy drinks, where it is often added as a supplement for its potential performance-enhancing effects. However, there is ongoing debate about the safety and efficacy of taurine supplementation in healthy individuals.

The MMPI, or Minnesota Multiphasic Personality Inventory, is a psychological assessment tool that is widely used in clinical and research settings to help evaluate an individual's personality, emotional state, and behavior. It consists of a series of true-false questions that are designed to measure various aspects of an individual's psychological functioning, including their attitudes, beliefs, and behaviors.

The MMPI was first developed in the 1930s and has undergone several revisions over the years. The current version, the MMPI-2, consists of 567 items and takes approximately 60-90 minutes to complete. The test is typically administered by a trained professional, such as a psychologist or counselor, who uses the results to help diagnose mental health conditions, develop treatment plans, and make recommendations about an individual's care.

It is important to note that while the MMPI can be a useful tool in assessing psychological functioning, it should not be used as the sole basis for making diagnostic or treatment decisions. It is typically used in conjunction with other assessment methods, such as clinical interviews and other tests, to provide a comprehensive picture of an individual's psychological state.

Genetic linkage is the phenomenon where two or more genetic loci (locations on a chromosome) tend to be inherited together because they are close to each other on the same chromosome. This occurs during the process of sexual reproduction, where homologous chromosomes pair up and exchange genetic material through a process called crossing over.

The closer two loci are to each other on a chromosome, the lower the probability that they will be separated by a crossover event. As a result, they are more likely to be inherited together and are said to be linked. The degree of linkage between two loci can be measured by their recombination frequency, which is the percentage of meiotic events in which a crossover occurs between them.

Linkage analysis is an important tool in genetic research, as it allows researchers to identify and map genes that are associated with specific traits or diseases. By analyzing patterns of linkage between markers (identifiable DNA sequences) and phenotypes (observable traits), researchers can infer the location of genes that contribute to those traits or diseases on chromosomes.

The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:

1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.

The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.

Ethnology is a branch of anthropology that focuses on the systematic study of the cultural, biological, social, and linguistic diversity of human groups both past and present. It involves the comparison and analysis of different ethnic groups, their customs, beliefs, and practices, with the aim of understanding the underlying patterns and processes that shape human culture and society.

In a medical context, ethnology can be used to study the cultural factors that influence health outcomes and healthcare practices among different populations. This may include examining traditional healing systems, attitudes towards illness and disease, and the social determinants of health in different ethnic groups. The insights gained from such research can help inform the development of culturally sensitive healthcare policies and interventions that are tailored to the needs of diverse communities.

Thiamine, also known as vitamin B1, is a water-soluble vitamin that plays a crucial role in certain metabolic reactions, particularly in the conversion of carbohydrates into energy in the body. It is essential for the proper functioning of the heart, nerves, and digestive system. Thiamine acts as a cofactor for enzymes involved in the synthesis of neurotransmitters and the metabolism of carbohydrates, lipids, and proteins. Deficiency in thiamine can lead to serious health complications, such as beriberi (a disease characterized by peripheral neuropathy, muscle wasting, and heart failure) and Wernicke-Korsakoff syndrome (a neurological disorder often seen in alcoholics due to chronic thiamine deficiency). Thiamine is found in various foods, including whole grains, legumes, pork, beef, and fortified foods.

Thiamine deficiency, also known as beriberi, is a condition that results from inadequate intake or impaired absorption of thiamine (vitamin B1), which is essential for energy metabolism and nerve function. This deficiency can lead to various symptoms such as peripheral neuropathy, muscle weakness, heart failure, and in severe cases, Wernicke-Korsakoff syndrome, a neurological disorder associated with alcoholism. Thiamine deficiency is commonly found in populations with poor nutrition, alcohol dependence, and gastrointestinal disorders affecting nutrient absorption.

The United States Substance Abuse and Mental Health Services Administration (SAMHSA) is not a medical term per se, but it is a government agency that focuses on improving the mental health and substance abuse services in the United States. Here's a definition of SAMHSA from a reputable source:

According to the National Library of Medicine's MedlinePlus, SAMHSA is defined as:

> "An agency within the U.S. Department of Health and Human Services that leads public health efforts to advance the behavioral health of the nation. SAMHSA's mission is to reduce the impact of substance abuse and mental illness on America's communities."

SAMHSA provides leadership and resources to address issues related to mental health and substance use disorders, including prevention, treatment, and recovery services. The agency works to improve the quality and availability of such services, as well as to promote awareness and understanding of behavioral health issues in the United States.

Alcoholic beverages are drinks that contain ethanol (ethyl alcohol), which is produced by the fermentation of yeast, sugars, and starches. The amount of alcohol in a drink is measured in terms of "alcohol content" or "alcohol by volume" (ABV). Different types of alcoholic beverages include:

1. Beer: A fermented beverage made from grains, such as barley, wheat, or rye. The alcohol content of beer typically ranges from 3-6% ABV.
2. Wine: A fermented beverage made from grapes or other fruits. The alcohol content of wine usually falls between 10-15% ABV.
3. Spirits (or liquors): Distilled beverages with higher alcohol content, typically ranging from 40-50% ABV. Examples include vodka, whiskey, rum, gin, and tequila.
4. Fortified wines: Wines that have had a distilled spirit added to them, increasing their alcohol content. Examples include port, sherry, and madeira, which typically contain 17-20% ABV.
5. Malt beverages: Fermented beverages made from malted barley or other grains, with additional flavorings or sweeteners. These can range in alcohol content from around 4-8% ABV.

It is important to note that excessive consumption of alcoholic beverages can lead to various health issues, including addiction, liver disease, and an increased risk of accidents and injuries. Moderate drinking is generally defined as up to one drink per day for women and up to two drinks per day for men, although individual tolerance and sensitivity to alcohol may vary.

Human chromosome pair 4 consists of two rod-shaped structures present in the nucleus of each cell in the human body. Each member of the pair is a single chromosome, and they are identical or very similar in length and gene content. Chromosomes are made up of DNA, which contains genetic information, and proteins that package and organize the DNA.

Human chromosomes are numbered from 1 to 22, with chromosome pair 4 being one of the autosomal pairs, meaning it is not a sex chromosome (X or Y). Chromosome pair 4 is a medium-sized pair and contains an estimated 1,800-2,000 genes. These genes provide instructions for making proteins that are essential for various functions in the body, such as development, growth, and metabolism.

Abnormalities in chromosome pair 4 can lead to genetic disorders, including Wolf-Hirschhorn syndrome, which is caused by a deletion of part of the short arm of chromosome 4, and 4p16.3 microdeletion syndrome, which is caused by a deletion of a specific region on the short arm of chromosome 4. These conditions can result in developmental delays, intellectual disability, physical abnormalities, and other health problems.

Electroencephalography (EEG) is a medical procedure that records electrical activity in the brain. It uses small, metal discs called electrodes, which are attached to the scalp with paste or a specialized cap. These electrodes detect tiny electrical charges that result from the activity of brain cells, and the EEG machine then amplifies and records these signals.

EEG is used to diagnose various conditions related to the brain, such as seizures, sleep disorders, head injuries, infections, and degenerative diseases like Alzheimer's or Parkinson's. It can also be used during surgery to monitor brain activity and ensure that surgical procedures do not interfere with vital functions.

EEG is a safe and non-invasive procedure that typically takes about 30 minutes to an hour to complete, although longer recordings may be necessary in some cases. Patients are usually asked to relax and remain still during the test, as movement can affect the quality of the recording.

Monoamine oxidase (MAO) is an enzyme found on the outer membrane of mitochondria in cells throughout the body, but primarily in the gastrointestinal tract, liver, and central nervous system. It plays a crucial role in the metabolism of neurotransmitters and dietary amines by catalyzing the oxidative deamination of monoamines. This enzyme exists in two forms: MAO-A and MAO-B, each with distinct substrate preferences and tissue distributions.

MAO-A preferentially metabolizes serotonin, norepinephrine, and dopamine, while MAO-B is mainly responsible for breaking down phenethylamines and benzylamines, as well as dopamine in some cases. Inhibition of these enzymes can lead to increased neurotransmitter levels in the synaptic cleft, which has implications for various psychiatric and neurological conditions, such as depression and Parkinson's disease. However, MAO inhibitors must be used with caution due to their potential to cause serious adverse effects, including hypertensive crises, when combined with certain foods or medications containing dietary amines or sympathomimetic agents.

Alcoholic hepatitis is a medical condition characterized by inflammation and damage to the liver caused by excessive alcohol consumption. It is a type of hepatitis that specifically results from alcohol abuse, rather than from viral infections or other causes. The condition can vary in severity, and long-term heavy drinking increases the risk of developing alcoholic hepatitis.

The inflammation in alcoholic hepatitis can lead to symptoms such as jaundice (yellowing of the skin and eyes), abdominal pain, nausea, vomiting, loss of appetite, and fever. In severe cases, it can cause liver failure, which may be life-threatening. Treatment typically involves alcohol abstinence, supportive care, and medications to manage symptoms and prevent further liver damage. In some cases, hospitalization and more intensive treatments may be necessary.

The United States Department of Health and Human Services (HHS) is not a medical term per se, but it is a government organization that oversees and provides funding for many public health initiatives, services, and institutions in the United States. Here's a brief definition:

The HHS is a cabinet-level department in the US federal government responsible for protecting the health of all Americans and providing essential human services. It achieves this by promoting effective and efficient delivery of high-quality healthcare, conducting critical medical research through its agencies, such as the National Institutes of Health (NIH), and enforcing public health laws and regulations, including those related to food safety, through its agencies, such as the Food and Drug Administration (FDA). Additionally, HHS oversees the Medicare and Medicaid programs, which provide healthcare coverage for millions of elderly, disabled, and low-income Americans.

Traumatic stress disorders are a category of mental health conditions that occur after exposure to a traumatic event or series of events. The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) recognizes several types of traumatic stress disorders, including:

1. Post-Traumatic Stress Disorder (PTSD): This disorder occurs after a person experiences or witnesses a traumatic event, such as combat, sexual assault, or a natural disaster. Symptoms include avoidance of reminders of the trauma, intrusive thoughts about the event, negative changes in mood and cognition, alterations in arousal and reactivity, and disturbances in sleep and concentration.
2. Acute Stress Disorder (ASD): This disorder is similar to PTSD but has a shorter duration. It occurs after exposure to a traumatic event and lasts for less than a month. Symptoms include dissociation, intrusive thoughts about the event, and avoidance of reminders of the trauma.
3. Adjustment Disorders: These disorders occur in response to a stressor or change in life circumstances, such as the loss of a job or the death of a loved one. Symptoms include anxiety, depression, and disturbances in conduct.
4. Reactive Attachment Disorder (RAD) and Disinhibited Social Engagement Disorder (DSED): These disorders occur in children who have experienced neglect or abuse and have difficulty forming attachments to caregivers.

It's important to note that traumatic stress disorders can have significant impacts on a person's daily functioning, relationships, and overall well-being. If you or someone you know is experiencing symptoms of a traumatic stress disorder, it's essential to seek professional help from a mental health provider.

Single Nucleotide Polymorphism (SNP) is a type of genetic variation that occurs when a single nucleotide (A, T, C, or G) in the DNA sequence is altered. This alteration must occur in at least 1% of the population to be considered a SNP. These variations can help explain why some people are more susceptible to certain diseases than others and can also influence how an individual responds to certain medications. SNPs can serve as biological markers, helping scientists locate genes that are associated with disease. They can also provide information about an individual's ancestry and ethnic background.

"Sex factors" is a term used in medicine and epidemiology to refer to the differences in disease incidence, prevalence, or response to treatment that are observed between males and females. These differences can be attributed to biological differences such as genetics, hormones, and anatomy, as well as social and cultural factors related to gender.

For example, some conditions such as autoimmune diseases, depression, and osteoporosis are more common in women, while others such as cardiovascular disease and certain types of cancer are more prevalent in men. Additionally, sex differences have been observed in the effectiveness and side effects of various medications and treatments.

It is important to consider sex factors in medical research and clinical practice to ensure that patients receive appropriate and effective care.

Alcoholic cardiomyopathy is a type of cardiomyopathy (a disease of the heart muscle) that is caused by excessive alcohol consumption. The condition is characterized by the progressive weakening and enlargement of the heart muscle, which can lead to heart failure. Over time, alcoholic cardiomyopathy can cause the heart to become weakened and unable to pump blood efficiently throughout the body. This can result in symptoms such as shortness of breath, fatigue, irregular heartbeat, and fluid retention.

The exact mechanism by which alcohol causes cardiomyopathy is not fully understood, but it is thought to involve a combination of factors, including direct toxic effects of alcohol on the heart muscle, nutritional deficiencies, and genetic predisposition. Treatment for alcoholic cardiomyopathy typically involves lifestyle changes such as abstaining from alcohol, as well as medications to manage symptoms and improve heart function. In severe cases, hospitalization or surgery may be necessary.

I'm sorry for any confusion, but "Hydroxytryptophol" is not a recognized or established term in medicine or biochemistry. It seems like it might be a combination of "hydroxytryptophan," which is a naturally occurring amino acid, and "-ol," which is a suffix often used to denote an alcohol. However, I can't find any scientific literature or studies referring to a compound named "Hydroxytryptophol." It's possible there might be a spelling mistake or a misunderstanding in the term. If you have more context or information, I'd be happy to help further!

Analysis of Variance (ANOVA) is a statistical technique used to compare the means of two or more groups and determine whether there are any significant differences between them. It is a way to analyze the variance in a dataset to determine whether the variability between groups is greater than the variability within groups, which can indicate that the groups are significantly different from one another.

ANOVA is based on the concept of partitioning the total variance in a dataset into two components: variance due to differences between group means (also known as "between-group variance") and variance due to differences within each group (also known as "within-group variance"). By comparing these two sources of variance, ANOVA can help researchers determine whether any observed differences between groups are statistically significant, or whether they could have occurred by chance.

ANOVA is a widely used technique in many areas of research, including biology, psychology, engineering, and business. It is often used to compare the means of two or more experimental groups, such as a treatment group and a control group, to determine whether the treatment had a significant effect. ANOVA can also be used to compare the means of different populations or subgroups within a population, to identify any differences that may exist between them.

A case-control study is an observational research design used to identify risk factors or causes of a disease or health outcome. In this type of study, individuals with the disease or condition (cases) are compared with similar individuals who do not have the disease or condition (controls). The exposure history or other characteristics of interest are then compared between the two groups to determine if there is an association between the exposure and the disease.

Case-control studies are often used when it is not feasible or ethical to conduct a randomized controlled trial, as they can provide valuable insights into potential causes of diseases or health outcomes in a relatively short period of time and at a lower cost than other study designs. However, because case-control studies rely on retrospective data collection, they are subject to biases such as recall bias and selection bias, which can affect the validity of the results. Therefore, it is important to carefully design and conduct case-control studies to minimize these potential sources of bias.

Wernicke Encephalopathy is a neuropsychiatric disorder that is caused by a deficiency of thiamine (vitamin B1). It is characterized by a classic triad of symptoms: confusion, oculomotor dysfunction (such as nystagmus and ophthalmoplegia), and gait ataxia. Other symptoms can include memory loss, apathy, and hypothermia.

Wernicke Encephalopathy is most commonly seen in alcoholics due to poor nutrition, but it can also occur in people with conditions that cause malabsorption or increased thiamine requirements, such as AIDS, cancer, and chronic diarrhea. Immediate treatment with thiamine replacement therapy is necessary to prevent progression of the disease and potential permanent neurological damage. If left untreated, Wernicke Encephalopathy can lead to Korsakoff's syndrome, a chronic memory disorder.

I believe there may be some confusion in your question. "Gypsies" is a term often used to refer to the Romani people, who are an ethnic group with a unique language and culture. It's important to note that using the term "Gypsy" as a medical label or definition can be considered pejorative and disrespectful, as it has been historically associated with discrimination and negative stereotypes.

If you're asking for a medical definition related to Romani people, there isn't one, as they are an ethnic group and not a medical condition. However, if you have any specific medical concerns or conditions in mind, I would be happy to help provide a definition or explanation for those.

A Genome-Wide Association Study (GWAS) is an analytical approach used in genetic research to identify associations between genetic variants, typically Single Nucleotide Polymorphisms (SNPs), and specific traits or diseases across the entire genome. This method involves scanning the genomes of many individuals, usually thousands, to find genetic markers that occur more frequently in people with a particular disease or trait than in those without it.

The goal of a GWAS is to identify genetic loci (positions on chromosomes) associated with a trait or disease, which can help researchers understand the underlying genetic architecture and biological mechanisms contributing to the condition. It's important to note that while GWAS can identify associations between genetic variants and traits/diseases, these studies do not necessarily prove causation. Further functional validation studies are often required to confirm the role of identified genetic variants in the development or progression of a trait or disease.

Psychiatric Status Rating Scales are standardized assessment tools used by mental health professionals to evaluate and rate the severity of a person's psychiatric symptoms and functioning. These scales provide a systematic and structured approach to measuring various aspects of an individual's mental health, such as mood, anxiety, psychosis, behavior, and cognitive abilities.

The purpose of using Psychiatric Status Rating Scales is to:

1. Assess the severity and improvement of psychiatric symptoms over time.
2. Aid in diagnostic decision-making and treatment planning.
3. Monitor treatment response and adjust interventions accordingly.
4. Facilitate communication among mental health professionals about a patient's status.
5. Provide an objective basis for research and epidemiological studies.

Examples of Psychiatric Status Rating Scales include:

1. Clinical Global Impression (CGI): A brief, subjective rating scale that measures overall illness severity, treatment response, and improvement.
2. Positive and Negative Syndrome Scale (PANSS): A comprehensive scale used to assess the symptoms of psychosis, including positive, negative, and general psychopathology domains.
3. Hamilton Rating Scale for Depression (HRSD) or Montgomery-Ã…sberg Depression Rating Scale (MADRS): Scales used to evaluate the severity of depressive symptoms.
4. Young Mania Rating Scale (YMRS): A scale used to assess the severity of manic or hypomanic symptoms.
5. Brief Psychiatric Rating Scale (BPRS) or Symptom Checklist-90 Revised (SCL-90-R): Scales that measure a broad range of psychiatric symptoms and psychopathology.
6. Global Assessment of Functioning (GAF): A scale used to rate an individual's overall psychological, social, and occupational functioning on a hypothetical continuum of mental health-illness.

It is important to note that Psychiatric Status Rating Scales should be administered by trained mental health professionals to ensure accurate and reliable results.

An endophenotype is a measurable biological or neurophysiological characteristic that is associated with a particular disease or disorder. It is thought to be a heritable component that contributes to the development and expression of the disease, and can be used to help understand the underlying genetic and neural mechanisms of the disorder. Endophenotypes are often quantifiable and can be observed in individuals both with and without the disorder, making them useful for research purposes. They may include biochemical measures, neurophysiological measures, neuroanatomical measures, or cognitive/neural performance measures.

A "delta rhythm" is a term used in electroencephalography (EEG) to describe a pattern of brain waves that are typically seen in the delta frequency range (0.5-4 Hz) and are maximal over the posterior regions of the head. This rhythm is often observed during deep sleep stages, specifically stage 3 and stage 4 of non-rapid eye movement (NREM) sleep, also known as slow-wave sleep.

Delta waves are characterized by their high amplitude and slow frequency, making them easily distinguishable from other brain wave patterns. The presence of a robust delta rhythm during sleep is thought to reflect the restorative processes that occur during this stage of sleep, including memory consolidation and physical restoration.

However, it's important to note that abnormal delta rhythms can also be observed in certain neurological conditions, such as epilepsy or encephalopathy, where they may indicate underlying brain dysfunction or injury. In these cases, the presence of delta rhythm may have different clinical implications and require further evaluation by a medical professional.

Comorbidity is the presence of one or more additional health conditions or diseases alongside a primary illness or condition. These co-occurring health issues can have an impact on the treatment plan, prognosis, and overall healthcare management of an individual. Comorbidities often interact with each other and the primary condition, leading to more complex clinical situations and increased healthcare needs. It is essential for healthcare professionals to consider and address comorbidities to provide comprehensive care and improve patient outcomes.

Corticotropin-releasing hormone (CRH) receptors are a type of G protein-coupled receptor found on the surface of cells in various tissues throughout the body. They play a critical role in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for the body's stress response.

There are two main types of CRH receptors: CRH-R1 and CRH-R2. When CRH binds to these receptors, it triggers a series of intracellular signaling events that ultimately lead to the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. ACTH then stimulates the production and release of cortisol, a steroid hormone that helps regulate metabolism, immune function, and stress response.

In addition to their role in the HPA axis, CRH receptors have been implicated in a variety of other physiological processes, including anxiety, depression, addiction, and pain perception. Dysregulation of the CRH system has been associated with several psychiatric and neurological disorders, making CRH receptors an important target for drug development in these areas.

A phenotype is the physical or biochemical expression of an organism's genes, or the observable traits and characteristics resulting from the interaction of its genetic constitution (genotype) with environmental factors. These characteristics can include appearance, development, behavior, and resistance to disease, among others. Phenotypes can vary widely, even among individuals with identical genotypes, due to differences in environmental influences, gene expression, and genetic interactions.

A LOD (Logarithm of Odds) score is not a medical term per se, but rather a statistical concept that is used in genetic research and linkage analysis to determine the likelihood of a gene or genetic marker being linked to a particular disease or trait. The LOD score compares the odds of observing the pattern of inheritance of a genetic marker in a family if the marker is linked to the disease, versus the odds if the marker is not linked. A LOD score of 3 or higher is generally considered evidence for linkage, while a score of -2 or lower is considered evidence against linkage.

Substance abuse treatment centers are healthcare facilities that provide a range of services for individuals struggling with substance use disorders (SUDs), including addiction to alcohol, illicit drugs, prescription medications, and other substances. These centers offer comprehensive, evidence-based assessments, interventions, and treatments aimed at helping patients achieve and maintain sobriety, improve their overall health and well-being, and reintegrate into society as productive members.

The medical definition of 'Substance Abuse Treatment Centers' encompasses various levels and types of care, such as:

1. **Medical Detoxification:** This is the first step in treating substance abuse, where patients are closely monitored and managed for withdrawal symptoms as their bodies clear the harmful substances. Medical detox often involves the use of medications to alleviate discomfort and ensure safety during the process.
2. **Inpatient/Residential Treatment:** This level of care provides 24-hour structured, intensive treatment in a controlled environment. Patients live at the facility and receive various therapeutic interventions, such as individual therapy, group counseling, family therapy, and psychoeducation, to address the underlying causes of their addiction and develop coping strategies for long-term recovery.
3. **Partial Hospitalization Programs (PHP):** Also known as day treatment, PHPs offer structured, intensive care for several hours a day while allowing patients to return home or to a sober living environment during non-treatment hours. This level of care typically includes individual and group therapy, skill-building activities, and case management services.
4. **Intensive Outpatient Programs (IOP):** IOPs provide flexible, less intensive treatment than PHPs, with patients attending sessions for a few hours per day, several days a week. These programs focus on relapse prevention, recovery skills, and addressing any co-occurring mental health conditions.
5. **Outpatient Treatment:** This is the least restrictive level of care, where patients attend individual or group therapy sessions on a regular basis while living at home or in a sober living environment. Outpatient treatment often serves as step-down care after completing higher levels of treatment or as an initial intervention for those with milder SUDs.
6. **Aftercare/Continuing Care:** Aftercare or continuing care services help patients maintain their recovery and prevent relapse by providing ongoing support, such as 12-step meetings, alumni groups, individual therapy, and case management.

Each treatment modality has its unique benefits and is tailored to meet the specific needs of individuals at various stages of addiction and recovery. It's essential to consult with a healthcare professional or an addiction specialist to determine the most appropriate level of care for each person's situation.

The frontal lobe is the largest lobes of the human brain, located at the front part of each cerebral hemisphere and situated in front of the parietal and temporal lobes. It plays a crucial role in higher cognitive functions such as decision making, problem solving, planning, parts of social behavior, emotional expressions, physical reactions, and motor function. The frontal lobe is also responsible for what's known as "executive functions," which include the ability to focus attention, understand rules, switch focus, plan actions, and inhibit inappropriate behaviors. It is divided into five areas, each with its own specific functions: the primary motor cortex, premotor cortex, Broca's area, prefrontal cortex, and orbitofrontal cortex. Damage to the frontal lobe can result in a wide range of impairments, depending on the location and extent of the injury.

In medical terms, "character" is not a term that has a specific or technical definition. It is a common English word that can have various meanings depending on the context in which it is used. In general, "character" refers to the personality traits, behaviors, and qualities that define an individual. However, in a medical or clinical setting, healthcare professionals may use the term "character" to describe certain aspects of a patient's symptoms, such as the quality, intensity, or duration of a particular symptom. For example, a patient's pain might be described as sharp, stabbing, or dull in character.

It is important to note that while healthcare professionals may use the term "character" to describe certain aspects of a patient's symptoms or condition, it is not a medical diagnosis or a specific medical term with a standardized definition.

Cooperative behavior, in a medical or healthcare context, refers to the actions and attitudes displayed by individuals or groups working together to achieve a common goal related to health and well-being. This may involve patients following their healthcare providers' advice, healthcare professionals collaborating to diagnose and treat medical conditions, or communities coming together to promote healthy behaviors and environments. Cooperative behavior is essential for positive health outcomes, as it fosters trust, communication, and shared decision-making between patients and healthcare providers, and helps to ensure that everyone involved in the care process is working towards the same goal.

Central pontine myelinolysis (CPM) is a neurological disorder that results from the damage to the myelin sheath in the central pons region of the brainstem. Myelin is the fatty substance that insulates and protects nerve fibers, allowing for the efficient transmission of electrical signals.

In CPM, the myelin sheath in the center of the pons area becomes damaged or destroyed due to various factors, most commonly rapid correction of hyponatremia (low sodium levels in the blood). This rapid correction can lead to an osmotic shift of water from inside the cells to outside, causing swelling and damage to the myelin sheath.

CPM is characterized by the development of symmetrical lesions in the central pons region, which can result in a range of neurological symptoms, including weakness or paralysis of muscles, difficulty swallowing, speech impairment, and altered levels of consciousness. In severe cases, CPM can lead to coma, respiratory failure, and even death.

It's important to note that the management of CPM involves preventing further damage to the myelin sheath by avoiding rapid correction of hyponatremia and providing supportive care for the neurological symptoms. Currently, there is no specific treatment for CPM, and recovery can be slow and incomplete.

"Native Americans" is the preferred term for the indigenous peoples of the continental United States, including those from Alaska and Hawaii. The term "Indians" is often used to refer to this group, but it can be seen as misleading or inaccurate since it implies a connection to India rather than recognition of their unique cultures and histories. However, some Native Americans prefer to use the term "Indian" to describe themselves.

It's important to note that there is no single medical definition for this group, as they are not a homogeneous population. Instead, they consist of hundreds of distinct tribes with diverse cultures, languages, and traditions. Each tribe may have its own unique genetic makeup, which can influence health outcomes and responses to medical treatments.

Therefore, when discussing medical issues related to Native Americans, it's essential to consider the specific tribal affiliations and cultural factors that may impact their health status and healthcare needs.

... is also associated with increases in violent and non-violent crime. While alcoholism directly resulted in 139,000 ... Most alcoholics develop alcoholism during adolescence or young adulthood. Alcoholism often reduces a person's life expectancy ... Genes that influence the metabolism of alcohol also influence the risk of alcoholism, as can a family history of alcoholism. ... Morse RM, Flavin DK (August 1992). "The definition of alcoholism. The Joint Committee of the National Council on Alcoholism and ...
... is a bimonthly peer-reviewed medical journal covering alcoholism and other health effects of alcohol. It ... In 1968, it was renamed the Journal of Alcoholism, and in 1977, it was again renamed, this time to British Journal on Alcohol ... It is the official journal of both the MCA and the European Society for Biomedical Research on Alcoholism. The editors-in-chief ... "Alcohol and Alcoholism". 2020 Journal Citation Reports. Web of Science (Science ed.). Clarivate Analytics. 2021. Official ...
The Alcoholism Treatment Quarterly is a quarterly peer-reviewed medical journal published by Taylor & Francis. The Co-Editors- ... Alcoholism Treatment Quarterly. Taylor & Francis. Retrieved 7 September 2014. PsycINFO Journal Coverage, American Psychological ...
... is a significant public health problem. In Ireland, 70.0% of Irish men and 34.1% of Irish women aged 15+ ... Alcohol abuse creates extensive problems on the Irish medical services, and alcoholism is implicated in at least three deaths a ... Local mental health services are also available to people suffering mental illness and alcoholism, who can then refer people to ... In Irish history, the Catholic Church attempted to suppress alcoholism in Ireland by encouraging some young Catholics to swear ...
Alcoholism throughout adolescents is increasing yearly for a number of different reasons. These reasons include: Availability ... Alcoholism: Clinical and Experimental Research, 38: 1622-1629. doi:10.1111/acer.12404 White, Helene Raskin; Jackson, Kristina ( ...
The Research Society on Alcohol (RSA) (formerly the Research Society on Alcoholism) is a learned society of over 1600 active ... Its objective is to advance research on alcohol use disorders (alcoholism) and the physiological and cognitive effects of ... The RSA holds an annual meeting and, together with the International Society for Biomedical Research on Alcoholism, sponsors ...
The Michigan Alcoholism Screening Test (MAST) screening tool was developed in 1971, and is one of the oldest alcoholism- ... Shields, A.L.; Howell, R. T.; Potter, J.; Weiss, R. D. (2007). "The Michigan Alcoholism Screening Test and Its Shortened Form: ...
... than alcoholism-ignorant modern historians realize." He also argues that alcoholism is often "not noticed outside the home ... The Andrew Johnson alcoholism debate is the dispute, originally conducted amongst the general public, and now typically a ... Harding...His weakness was alcoholism. He made a fearful exhibition of himself at the time of his inauguration and during the ... In the end, whether or not he exhibited clinically significant symptoms of alcoholism during his Presidency, after the March 4 ...
Alcohol in rural Australia is the most frequently used drug by residents living in all isolated, remote and rural regions in Australia. Alcohol consumption is particularly misused by individuals in these areas due to numerous factors distinctive of rural Australia. These factors consist of the reduced access to education and health care professionals with alcohol treatment services, leading to higher rates of unemployment and economic disadvantage. These characteristics promote increased levels of disease, injury and death as a result of the high alcohol-related harms that are substantial in rural communities across Australia. The Australian Institute of Health and Welfare (AIHW) states that 80% of Australians regularly consume alcohol. In Australia, a third of the population live in remote and rural areas, where a proportion of these adults engage in risk-taking behaviours such as excessive alcohol misuse which is significantly higher than in major cities of Australia. In 2010, the National ...
... refers to the conditions in families that enable alcoholism and the effects of alcoholic behavior ... Alcoholism is more prevalent among child-abusing parents. Alcoholism is more strongly correlated to child abuse than depression ... Research shows that ACOAs feel less like blaming their parents for their alcoholism after learning that alcoholism is a disease ... Cermak, TL (1989). "Al-Anon and recovery". Recent Developments in Alcoholism. Recent Developments in Alcoholism. Vol. 7. pp. 91 ...
"World League Against Alcoholism". Westerville Public Library. Retrieved 17 May 2023. "World League Against Alcoholism: World- ... World League against alcoholism: World-wide prohibition. Alcohol Problems and Solutions. (2023, May 8). v t e (Articles with ... It became unable to continue supporting the World League Against Alcoholism. Cherrington was forced to lead it with little ... The World League Against Alcoholism was organized by the Anti-Saloon League, whose goal became establishing prohibition not ...
The risk of developing alcoholism depends on many factors, such as environment. Those with a family history of alcoholism are ... "Many doctors have been loath to prescribe drugs to treat alcoholism, sometimes because of the belief that alcoholism is a moral ... National Institute on Alcohol Abuse Alcoholism. January 18, 2005. Retrieved February 15, 2020. "Alcoholism Isn't What It Used ... Not only does alcoholism not follow the model of a 'disease,' it is not amenable to standard medical treatment." She says that ...
... is a book by Jeffery Brandsma, Maxie C. Maultsby Jr., and Richard J. Welsh, published in ... Brandsma, Jeffery M; Maultsby, Maxie C; Welsh, Richard J (1980). Outpatient Treatment of Alcoholism: a review and comparative ... some alcoholism study subjects always go to AA on their own, even if not specifically assigned to go". "Jeffrey Melvin Brandsma ... and about as effective as the three other alcoholism treatments. According to the study, both the AA-style and the lay-RBT ...
... is a scientific journal covering research concerning alcohol abuse and its ... It is published by Wiley-Blackwell on behalf of the Research Society on Alcoholism and the International Society for Biomedical ... Research on Alcoholism. The journal is abstracted and indexed in Academic Search, Current Awareness in Biological Sciences, ... ". "Journal Information". Alcoholism: Clinical and Experimental Research. Wiley-Blackwell. Archived from the original on 30 ...
"Alcoholism." Emedicine.com. Etiology and Natural History of Alcoholism. National Institute on Alcohol Abuse and Alcoholism. ( ... "Alcoholism can simultaneously reflect both a conditioned habit and a disease." Factors predicting alcoholism were related to ... Depression, clinically so often found to occur with alcoholism, was likewise found to be a result of alcoholism. Evidence such ... Unhappy family environments caused alcoholism only if the unhappy environments were the result of alcoholism in the first place ...
... which could lead to therapeutic targets for alcoholism. Treatments for alcoholism aim to end ethanol consumption and provide ... In Alcoholism (p. 14). Santa Barbara, Calif.: Greenwood Press/ABC-CLIO. Bolanos, C. A. and Nestler, E. J. (2004). Neurotrophic ... Alcoholism: Clinical and Experimental Research, 27(3), 396-409. Pandey, S.C., Roy, A., Mittal, N. (2001). Effects of chronic ... Whether or not tolerance and alcoholism are related is still under debate. Further work must be done in order to find a ...
In studying alcoholism, COGA hopes to find better ways of treating alcoholism and improving the lives of the millions of people ... The Collaborative Study on the Genetics of Alcoholism: An Update Alcoholism and Human Electrophysiology Defining Alcohol- ... "Collaborative Studies on Genetics of Alcoholism (COGA) Study". National Institute on Alcohol Abuse and Alcoholism (NIAAA). 2011 ... There is a large body of twin-studies and adoption-studies that show that the risk for alcoholism has a genetic component. COGA ...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA), as part of the U.S. National Institutes of Health, supports and ... Past directors from 1972-present The mission of the National Institute on Alcohol Abuse and Alcoholism is to generate and ... "Mission Statement". National Institute on Alcohol Abuse and Alcoholism (NIAAA). "Our Work". National Institute on Alcohol Abuse ... Project MATCH, an initialism for: Matching Alcoholism Treatments to Client Heterogeneity Heilig, Markus; Warren, Kenneth R.; ...
McCurdy, Jennette (September 2, 2020). "alcoholism". Empty Inside. Archived from the original on November 28, 2020. Retrieved ...
Alcoholism may have been widespread in Rome from 600 BCE to 100 CE. Alcohol was common amongst both the upper and lower classes ... Pliny the Elder, in his book Natural History, describes cases of alcoholism. He states that "a great part of mankind are of the ... However, alcoholism or excessive drinking would result in the opposite. Many ancient authors condemned drinking, believing it ... Ancient literature provides a few examples of alcoholism. Mark Antony was said to be a heavy drinker. Asclepiades of Ephesus ...
In keeping with his other works, themes include: Los Angeles bar culture; alcoholism; gambling; sex and violence. However, many ...
Alcoholism; age disparities in sexual relationships; Corruption or Exploitation; Unjust firings; Diabetes; Male infertility; ...
"Alcoholism; or, You Got to Find the World Interesting", Definition, 1962. "The Ordinary Doom", A Book of Nonfiction, (New York ...
Alcohol and Alcoholism 2011; 46: 210-13. Two articles among many are Effects of Alcohol Advertising Exposure on Drinking Among ... In: Wekesser, Carol (ed.) Alcoholism. San Diego, CA: Greenhaven Press, 1994. Pp. 132-135, p. 133. Petticrew M, Maani Hessari N ... There have also been various campaigns to help prevent alcoholism, under-age drinking and drunk driving. These include ... In: Wekesser, Carol (ed.) Alcoholism. San Diego, CA: Greenhaven Press, 1994. Pp. 132-135, p. 133. "Issues" at the Distilled ...
Anti-vivisection 4961-4995............Degeneration 5001-5720.5..........Alcoholism. Intemperance. Temperance reform 5725-5770 ...
In: Roleff, T. (ed). Alcoholism. Detroit, MI: Greenhaven Press, 2010. Alcohol Advertising. In: Esposito, R. (ed). Mass Media. ... "Find Alcoholism Help" Disclaimer for the website "Alcohol Facts" Webpage about David J. Hanson Alcohol: Problems and Solutions ... Alcohol Facts Find Alcoholism Help Mangled Drunk Driving Data? - Dr. David J. Hanson interview Fox News: Lawsuits, Alcohol ...
... alcoholism; feeling betrayed, violated, angry, violent towards the perpetrator, powerless or out of control; increased blood ...
Alcoholism. [and] Roman Catholic nuns." According to The Times (London), Flora (2013) "encompasses most of the themes that have ...
"Alcoholism". onf-nfb.gc.ca. National Film Board of Canada. Retrieved April 15, 2023. "Regards Sur le Canada". onf-nfb.gc.ca. ... The episode Alcoholism won the Frigon Trophy for Best Canadian Television Programme on Film at the 1957 Gala Radiomonde et ... Three On the Spot episodes were produced in French: Alcoholism (L'alcoolisme, est-ce une maladie?), Artists in Montreal ( ...
... alcoholism." In the late 1980s, Bread had the third-highest viewing figures on British television, beaten only by EastEnders ...
With regard to alcoholism, BAC is useful to judge alcohol tolerance, which in turn is a sign of alcoholism.[4] Electrolyte and ... Alcoholism. The term alcoholism is commonly used amongst laypeople, but the word is poorly defined. Despite the imprecision ... Alcoholism is also associated with increases in violent and non-violent crime.[22] While alcoholism directly resulted in ... Morse RM, Flavin DK (August 1992). "The definition of alcoholism. The Joint Committee of the National Council on Alcoholism and ...
Neural roots/origins of alcoholism identified. Date:. February 8, 2021. Source:. University of Warwick. Summary:. The physical ... "Neural roots/origins of alcoholism identified." ScienceDaily. www.sciencedaily.com. /. releases. /. 2021. /. 02. /. ... "Neural roots/origins of alcoholism identified." ScienceDaily. ScienceDaily, 8 February 2021. ,www.sciencedaily.com. /. releases ... 2021, February 8). Neural roots/origins of alcoholism identified. ScienceDaily. Retrieved December 2, 2023 from www. ...
About Alcoholism. Receive information and a free assessment on alcohol addiction and chronic alcohol problems. ... Find help for drug addiction and alcoholism through this Narconon First Step drug rehabilitation program. See how the First ... Step can start thew process of treating drug addiction or alcoholism.. Se connecter Narconon First Step , Etiquette de contenu ...
Alcoholism is common, serious, and expensive. Physicians encounter alcohol-related cirrhosis, cardiomyopathy, pancreatitis, and ... Alcoholism is slightly more common in lower income and less educated groups. Vaillant studied the natural history of alcoholism ... Among older patients with alcoholism, from one third to one half develop alcoholism after age 60 years. This group is harder to ... encoded search term (Alcoholism) and Alcoholism What to Read Next on Medscape ...
... alcoholism, Alcoholics Anonymous, alcoholic drinks, alcohol poisoning, and other health risks. ... What are symptoms of alcoholism?. Symptoms of alcoholism, or alcohol dependence, include: - Craving: Persistent thoughts about ... Alcohol Quiz: Alcoholism & Health Effects. *Reviewed by John P. Cunha, DO, FACOEP on January 17, 2017 ... health & living center/nutrition, food & recipes a-z list/quizzes a-z list/alcohol quiz: alcoholism & health effects ...
There are various medications for alcoholism that doctors may prescribe to help people manage their condition. The medical term ...
Alcoholism is common, serious, and expensive. Physicians encounter alcohol-related cirrhosis, cardiomyopathy, pancreatitis, and ... This study applies to early-onset alcoholism and type 2 alcoholism. More work is needed on later-onset alcoholism and type 1 ... Sons of persons with type 2 alcoholism are 7 times more likely to develop type 2 alcoholism compared with the general ... Physicians might not know how to screen for and diagnose alcoholism. However, screening for alcoholism is important (see CAGE ...
Alcohol use disorder (AUD) is a diagnosis once referred to as "alcoholism." Its a condition characterized by patterns of ... Alcohol use disorder, formerly called alcoholism, is both a mental health condition and a disease. ...
... December 11, 2023. December 10, 2023. by David W. Newton ...
Kristen Bell Reveals the Biggest Lesson She Learned From Dax Shepards Alcoholism Recovery. The mom of two talks about her what ... Especially from watching her husband Dax and his recovery from alcoholism. Like certain mechanisms for when things are feeling ...
Researchers at the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and ... Cite this: Heart Failure Drug a New Treatment Option for Alcoholism? - Medscape - Sep 27, 2022. ...
Teenage Alcoholism Effects And Remedies. Alcoholism can be a difficult problem to deal with, and teenage alcoholism is no ... The Difference Between Alcoholism and Drinking. Everything taken and done excessively is bad and harmful whether it is for ... Alcoholism is accepted as a disease, and there are cures available. Group counseling, as offered by groups like Alcoholics ... Other than the health related problems associated with alcoholism that requires physical and medical... ...
Actor Simon Pegg has revealed ton Desert Island Discs hat he kept his alcoholism secret on the set of Mission: Impossible. ... Actor Simon Pegg has revealed that he kept his alcoholism secret on the set of Mission: Impossible. ...
You know, seminal American author John Cheever and I have a lot in common. He needed to drink a fifth of scotch before he had the courage to utter a word to another human being, and so do I. Much like Cheever, Im completely blotto by 10 a.m. because of a deep, withering fear that my family will eventually discover my…
... formerly called alcoholism, is both a mental health condition and a disease. ... alcoholism as a disease, meaning people should be hospitalized and treated for the condition. The AMA emphasized that in the ... The categorization of "alcoholism" has changed over time. Recognizing alcohol use disorder as a mental health condition ... The APA no longer clinically use the terms "alcohol abuse" and "alcoholism" because theyre less accurate and contribute to ...
is a in the SoberRecovery : Alcoholism Drug Addiction Help and Information. View ...
Senate Standing Committee on Alcoholism and Drug Abuse Senator Jeffrey D. Klein, Chair 10:00 AM, Thursday, January 19, 2012 ... Alcoholism and Substance Abuse, Substance Abuse Treatment, Senator Harckham. SD40 Senators Harckham/Mayer Hold Press Conference ... Senate Standing Committee on Alcoholism and Drug Abuse Senator Jeffrey D. Klein, Chair 10:00 AM, Thursday, January 19, 2012 ...
Coronavirus Pandemic; COVID-19, Alcoholism and Drug Abuse, Alcoholism and Substance Abuse, Addiction and Overdose Prevention ... kratom, Alcoholism and Drug Abuse A Statement from Senator Pam Helming On Her Bill Banning the Sale of Kratom to Minors Pamela ... Alcoholism and Drug Abuse, Combat Heroin and Opioid Addiction, Heroin & Opioid Abuse, Heroin & Opioid Funding ... New York State budget, Heroin & Opioid Task Force, Heroin & Opioid Funding, Alcoholism and Drug Abuse ...
News / Lifestyle / Relationships / Alcohol advertisements make teenagers vulnerable to alcoholism. Heres why ... Alcohol advertisements make teenagers vulnerable to alcoholism. Heres why. Washington D.C. [USA], , ByAsian News International ...
Princeton area community website with events, comprehensive business listings, and local information
Alcoholism -- Treatment -- Social aspects -- United States. Filed under: Alcoholism -- Treatment -- United States*. The ... Subcommittee on Alcoholism and Narcotics (page images at HathiTrust). *. Alcoholism, getting the facts.. (National Institute on ... Treating alcoholism : the illness, the symptoms, the treatment.. (National Institute on Alcohol Abuse & Alcoholism, 1974), by ... Training alcoholism trainers : a program for trainers in the field of alcoholism : participant workbook. (Dept. of Health, ...
Alcoholism dominated his life. "Normally when I got drunk I would just fall asleep, but my family have seen me in some pretty ... MDMA cured my alcoholism: Inside the remarkable ecstasy trial offering an escape from trauma Dave Pounds hit the bottle after ...
Filed under: Addiction, alcoholism, personal essay, Quitter, recovery, sobriety Addiction, Drugs, Featured, Health, ... Filed under: Addiction, alcoholism, Quitter, women Addiction, Featured July 7, 2020. July 7, 2020. ... Filed under: Addiction, alcoholism, harm reduction, King County Addiction, Featured March 2, 2020. ... Filed under: Addiction, alcoholism, Quitter Addiction June 30, 2020. June 30, 2020. ...
Several SNPs have been implicated in the tendency towards and/or the treatment of alcoholism, including: *29 variants were ... Alcohol dependence, popularly known as alcoholism, is a psychiatric diagnosis describing a physical dependence on alcohol. ... rs1076560 as a potentially important variable in the development of alcoholism [PMID 17196743] ... and also predicts the efficacy of treatment of alcoholism with the drug naltrexone ...
is a in the SoberRecovery : Alcoholism Drug Addiction Help and Information. View ...
... which could provide new insights into the genetic roots of alcoholism in humans has been pinpointed by scientists. ... A novel mutation in a mouse gene, which could provide new insights into the genetic roots of alcoholism in humans has been ... Studies of human twins have suggested that there is a genetic component to alcoholism, but, according to Speca, it is likely ... Alcohol use disorder or alcoholism is an inability to control drinking. It can cause short term and long term ... ...
ATLANTIC CITY - "More people died of drug and alcohol abuse in 2017 than died in the entire Viet Nam war," declares Mikee "Whiteshoes" Williamson, director of The Jesus House. Williamson ...
Alcoholism is one of those things nobody really wants to acknowledge when its right in front of them. Are you pulling the wool ... Alcoholism Cant Happen In My Family. Published: 6th March, 2010 Categorized: Alcohol Rehab ... over your own eyes? Take a closer look at how alcoholism could be in your family, even if you dont want to see it. ...
National Brain Awareness Week programs were established by the Dana Alliance for Brain Initiatives (Dana) to link scientists, clinicians, journalists, and other educators in an annual effort to raise public awareness about the brain and brain science. For more information about Brain Awareness Week programs in Silver Spring, MD, visit https://www.medicalmuseum.mil/index.cfm?p=education.brain_awareness_week.index.
  • Furthermore, it has a greater sensitivity in populations with a lower prevalence of alcoholism. (medscape.com)
  • The two largest studies, the US National Comorbidity Survey and the Epidemiologic Catchment Area Survey , both showed a lower prevalence of alcoholism in black Americans than in white Americans. (medscape.com)
  • [4] Medically, alcoholism is considered both a physical and mental illness. (wikipedia.org)
  • Recognized substance abuse patients tend to have an antisocial personality disorder (type 2 alcoholism, characterized by an association with criminal behavior [sociopathy], onset in teen years, and drinking to get high), while those whose diagnosis is missed tend to have depression or anxiety. (medscape.com)
  • Alcohol use disorder (AUD) is a diagnosis once referred to as "alcoholism. (healthline.com)
  • First-degree relatives of individuals with alcohol use disorder are four to seven times more likely to develop alcoholism than the general population. (emedicinehealth.com)
  • In many cases, alcoholism is often linked to depression and post-traumatic stress disorder (PTSD). (mixmag.net)
  • The development of alcoholism is attributed to both environment and genetics equally. (wikipedia.org)
  • Is Alcoholism Genetic? (healthline.com)
  • A novel mutation in a mouse gene, which could provide new insights into the genetic roots of alcoholism in humans has been pinpointed by scientists. (medindia.net)
  • Studies of human twins have suggested that there is a genetic component to alcoholism, but, according to Speca, it is likely that there are multiple genes that contribute to the disease, each with its own effect, making it difficult to identify the causative factors. (medindia.net)
  • These findings support the hypothesis that family environment effects do make a difference in accounting for offspring outcomes, in particular, that a low-risk environment (i.e., the absence of parental alcoholism) can moderate the impact of high genetic risk regarding offspring for the development of alcohol-use disorders,' the study authors write. (healthday.com)
  • A twin study revealed that the genetic heritability of alcoholism was between 40% and 60% in Caucasian populations 16 . (nature.com)
  • What are symptoms of alcoholism? (medicinenet.com)
  • What Are Alcoholism Symptoms and Signs? (emedicinehealth.com)
  • The symptoms of alcoholism can vary from person to person, but there are some common symptoms. (allencarr.com)
  • The symptoms of alcoholism can vary from person to person, but some common symptoms include drinking more alcohol than intended or for longer periods of time than intended, being unable to cut down or stop drinking despite trying to do so, and spending a lot of time drinking or recovering from the effects of alcohol. (allencarr.com)
  • Other signs of alcoholism can be craving alcohol or experiencing strong urges to drink, continuing to drink despite negative consequences such as relationship problems, job loss, or legal issues, and giving up or reducing activities that were once important to you in order to drink or because you're finding the symptoms of alcoholism prevent you from doing so. (allencarr.com)
  • Alcoholism symptoms also involve developing a tolerance to alcohol, meaning that you need to drink more to achieve the same effects and experiencing withdrawal symptoms such as shakiness, sweating, nausea, or anxiety when not drinking. (allencarr.com)
  • The students understand the nurse's importance in the early diagnosis of signs and symptoms of alcoholism, its abstinence and welfare possibilities for the area, but feel unprepared and insecure facing this multidisciplinary phenomenon that is alcoholism. (bvsalud.org)
  • There's a chance that it's part of a new and relatively unexplored biochemical pathway that may tell us something about human susceptibility to alcoholism," notes Speca. (medindia.net)
  • Therefore, we used an event-history with risk-free model to simultaneously characterize alcoholism susceptibility and onset age in 65 independent non-Hispanic Caucasian males in the Collaborative Study on the Genetics of Alcoholism. (nature.com)
  • Although the dangers of alcoholism are well known, data suggest that physicians frequently fail to make the diagnosis. (medscape.com)
  • Alcohol dependence , popularly known as alcoholism , is a psychiatric diagnosis describing a physical dependence on alcohol. (snpedia.com)
  • A first-of-its-kind trial using MDMA alongside psychotherapy to try and stop alcoholism appears to have been successful, scientists revealed. (dailymail.co.uk)
  • Back in April of this year, Imperial College London began clinical trials for the treatment of alcoholism through the use of MDMA-assisted therapy. (mixmag.net)
  • Genetics and Alcoholism: What's the Connection? (healthline.com)
  • This study provides a more comprehensive understanding of the genetics of alcoholism than previous case-control studies. (nature.com)
  • Researchers at the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and Yale University School of Medicine investigated the impact of spironolactone on AUD. (medscape.com)
  • AUD was known as "alcoholism" until 1994 , when the American Psychiatric Association (APA) discarded that term in favor of "alcohol abuse" and "alcohol dependence. (healthline.com)
  • The APA no longer clinically use the terms "alcohol abuse" and " alcoholism " because they're less accurate and contribute to stigma around the condition. (healthline.com)
  • The National Institute on Alcohol Abuse and Alcoholism (NIAAA) defines binge drinking as a pattern of drinking alcohol that brings blood alcohol concentration (BAC) to 0.08%-or 0.08 grams of alcohol per deciliter-or more. (nih.gov)
  • In general, moderate drinking is defined as up to one drink per day for women and up to two drinks per day for men, according to the National Institute on Alcohol Abuse and Alcoholism. (allencarr.com)
  • Per the National Institute on Alcohol Abuse and Alcoholism, just serving in the military tends to increase drinking. (recoveryfirst.org)
  • He has been Director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) since 2014, and he wants everyone to know what the institute has to offer. (medlineplus.gov)
  • Social factors such as the influence of family, peers, and society, and the availability of alcohol, and psychological factors such as elevated levels of stress , inadequate coping mechanisms, and reinforcement of alcohol use from other drinkers can contribute to alcoholism. (emedicinehealth.com)
  • A review of the many attempts to establish an association between occupations and alcoholism reveals that most do not deal with data about clinically defined alcoholism but instead use data about cirrhosis mortality, self-reported alcohol problems, and frequent and heavy drinking. (nih.gov)
  • Alcoholism and drug dependence : a multidisciplinary approach , proceedings of the Third International Conference on Alcoholism and Drug Dependence held in Liverpool, England, April 4-9, 1976 / edited by J. S. Madden, Robin Walker and W. H. Kenyon. (who.int)
  • Depression, anxiety, and antisocial personality all are more common in persons with alcoholism than in the general population (20.5% vs 7.2%, 23.5% vs 11.1%, and 18.3% vs 3.6%, respectively). (medscape.com)
  • The AMA emphasized that in the case of alcoholism (as opposed to intoxication ), the person did not have control over their alcohol use. (healthline.com)
  • Treatment of alcoholism may take several forms. (wikipedia.org)
  • Resource guide for treatment options for recovery from drug addiction and alcoholism. (icra.org)
  • This contributes to the belief among many physicians that alcoholism is not treatable, despite good evidence to the contrary (see Treatment). (medscape.com)
  • Heart Failure Drug a New Treatment Option for Alcoholism? (medscape.com)
  • Medicare coverage for the treatment of alcoholism : excerpts. (upenn.edu)
  • NDATUS state data collection procedures and quality control manual : 1982 National Drug and Alcoholism Treatment Utilization Survey. (upenn.edu)
  • NDATUS instruction manual : 1982 national drug and alcoholism treatment utilization survey. (upenn.edu)
  • Unfortunately, many Veterans who need treatment for alcoholism do not receive it. (recoveryfirst.org)
  • What are the behavioural and social signs of alcoholism? (allencarr.com)
  • In this article, Glen Rosenberger examines a definition and biblical view of alcoholism, how alcoholism has been dealt with within the church and practical ways to counsel and help the alcoholic. (ccef.org)
  • Alcoholism is the continued drinking of alcohol despite negative results. (wikipedia.org)
  • Alcoholism is the drinking of alcohol to the point that causes problems, and continuing to drink even after problems arise. (wikipedia.org)
  • Alcoholism is also associated with increases in violent and non-violent crime. (wikipedia.org)
  • Alcoholism is characterised by an increased tolerance to alcohol - which means that an individual can consume more alcohol - and physical dependence on alcohol, which makes it hard for an individual to control their consumption. (wikipedia.org)
  • Fast Five Quiz: How Much Do You Know About Alcoholism? (medscape.com)
  • Alcoholism can have adverse effects on mental health, contributing to psychiatric disorders and increasing the risk of suicide. (wikipedia.org)
  • Find help for drug addiction and alcoholism through this Narconon First Step drug rehabilitation program. (icra.org)
  • See how the First Step can start thew process of treating drug addiction or alcoholism. (icra.org)
  • Get updates about Senate activity regarding Alcoholism and Drug Abuse. (nysenate.gov)
  • Many terms, some slurs and some informal, have been used to refer to people affected by alcoholism such as tippler, drunkard, dipsomaniac and souse. (wikipedia.org)
  • There are various medications for alcoholism that doctors may prescribe to help people manage their condition. (medicalnewstoday.com)
  • But in 1956, the AMA officially designated alcoholism as a disease, meaning people should be hospitalized and treated for the condition. (healthline.com)
  • It is a shared reality that alcoholism is a disease that impacts millions of people globally. (audioboo.fm)
  • [22] While alcoholism directly resulted in 139,000 deaths worldwide in 2013, [23] in 2012 3.3 million deaths may be attributable globally to alcohol. (wikipedia.org)
  • However, screening for alcoholism is important (see CAGE questionnaire and AUDIT). (medscape.com)
  • Physicians frequently share the responsibility for the failure to diagnose alcoholism. (medscape.com)
  • As far back as 1933 , the Standard Classified Nomenclature of Diseases listed alcoholism as a disease. (healthline.com)
  • Alcoholism is a disease. (emedicinehealth.com)
  • Other than the health related problems associated with alcoholism that requires physical and medical. (home-remedies-for-you.com)
  • Take a closer look at how alcoholism could be in your family, even if you don't want to see it. (orchidrecoverycenter.com)
  • Alcoholism can cause a person to lose friends, family, jobs and the respect of others. (davidwolfe.com)
  • In this video, Teddy, an anonymous Al‑Anon member, shares how her partners' alcoholism affected her family. (al-anon.org)
  • The small study conducted on four willing participants who suffered from alcoholism took place over eight weeks. (mixmag.net)
  • 2 Veterans who suffer from alcoholism may have begun misusing alcohol while still in active duty as a way to cope with problems like stress or isolation. (recoveryfirst.org)
  • [29] Various individual or group therapy or support groups are used to attempt to keep a person from returning to alcoholism. (wikipedia.org)
  • Laboratory tests have a sensitivity of no better than 50%, and physical examination is helpful only after the consequences of alcoholism are apparent. (medscape.com)
  • The study's lead author, Addictions Psychiatrist Dr. Ben Sessa , has called current treatments for alcoholism "really poor" and says MDMA's medical potential is currently being undermined pharmaceutical companies. (mixmag.net)
  • Research has implicated a gene (D2 dopamine receptor gene) that, when inherited in a specific form, might increase a person's chance of developing alcoholism. (emedicinehealth.com)