Adaptation, Physiological: The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.Adaptation, Ocular: The adjustment of the eye to variations in the intensity of light. Light adaptation is the adjustment of the eye when the light threshold is increased; DARK ADAPTATION when the light is greatly reduced. (From Cline et al., Dictionary of Visual Science, 4th ed)Adaptation, Biological: Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.Dark Adaptation: Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.Figural Aftereffect: A perceptual phenomenon used by Gestalt psychologists to demonstrate that events in one part of the perceptual field may affect perception in another part.Adaptation, Psychological: A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed)Acclimatization: Adaptation to a new environment or to a change in the old.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Photic Stimulation: Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.Afterimage: Continuation of visual impression after cessation of stimuli causing the original image.Dental Marginal Adaptation: The degree of approximation or fit of filling material or dental prosthetic to the tooth surface. A close marginal adaptation and seal at the interface is important for successful dental restorations.Selection, Genetic: Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Contrast Sensitivity: The ability to detect sharp boundaries (stimuli) and to detect slight changes in luminance at regions without distinct contours. Psychophysical measurements of this visual function are used to evaluate visual acuity and to detect eye disease.Stress, Physiological: The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.Altitude: A vertical distance measured from a known level on the surface of a planet or other celestial body.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Environment: The external elements and conditions which surround, influence, and affect the life and development of an organism or population.Translations: Products resulting from the conversion of one language to another.Visual Perception: The selecting and organizing of visual stimuli based on the individual's past experience.Psychomotor Performance: The coordination of a sensory or ideational (cognitive) process and a motor activity.Motion Perception: The real or apparent movement of objects through the visual field.Sensory Thresholds: The minimum amount of stimulus energy necessary to elicit a sensory response.Photoreceptor Cells: Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.Perceptual Distortion: Lack of correspondence between the way a stimulus is commonly perceived and the way an individual perceives it under given conditions.Cold Temperature: An absence of warmth or heat or a temperature notably below an accustomed norm.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Genetic Variation: Genotypic differences observed among individuals in a population.Psychophysics: The science dealing with the correlation of the physical characteristics of a stimulus, e.g., frequency or intensity, with the response to the stimulus, in order to assess the psychologic factors involved in the relationship.Models, Neurological: Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Vision, Ocular: The process in which light signals are transformed by the PHOTORECEPTOR CELLS into electrical signals which can then be transmitted to the brain.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Climate Change: Any significant change in measures of climate (such as temperature, precipitation, or wind) lasting for an extended period (decades or longer). It may result from natural factors such as changes in the sun's intensity, natural processes within the climate system such as changes in ocean circulation, or human activities.Genetic Fitness: The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Ecosystem: A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Learning: Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.Orientation: Awareness of oneself in relation to time, place and person.Bacterial Proteins: Proteins found in any species of bacterium.Saccades: An abrupt voluntary shift in ocular fixation from one point to another, as occurs in reading.Cultural Characteristics: Those aspects or characteristics which identify a culture.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Pattern Recognition, Visual: Mental process to visually perceive a critical number of facts (the pattern), such as characters, shapes, displays, or designs.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Short Bowel Syndrome: A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Rotation: Motion of an object in which either one or more points on a line are fixed. It is also the motion of a particle about a fixed point. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Language: A verbal or nonverbal means of communicating ideas or feelings.Reaction Time: The time from the onset of a stimulus until a response is observed.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Translating: Conversion from one language to another language.Face: The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw.Retinal Rod Photoreceptor Cells: Photosensitive afferent neurons located in the peripheral retina, with their density increases radially away from the FOVEA CENTRALIS. Being much more sensitive to light than the RETINAL CONE CELLS, the rod cells are responsible for twilight vision (at scotopic intensities) as well as peripheral vision, but provide no color discrimination.Color Perception: Mental processing of chromatic signals (COLOR VISION) from the eye by the VISUAL CORTEX where they are converted into symbolic representations. Color perception involves numerous neurons, and is influenced not only by the distribution of wavelengths from the viewed object, but also by its background color and brightness contrast at its boundary.Physical Conditioning, Animal: Diet modification and physical exercise to improve the ability of animals to perform physical activities.Reflex, Vestibulo-Ocular: A reflex wherein impulses are conveyed from the cupulas of the SEMICIRCULAR CANALS and from the OTOLITHIC MEMBRANE of the SACCULE AND UTRICLE via the VESTIBULAR NUCLEI of the BRAIN STEM and the median longitudinal fasciculus to the OCULOMOTOR NERVE nuclei. It functions to maintain a stable retinal image during head rotation by generating appropriate compensatory EYE MOVEMENTS.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Feedback, Sensory: A mechanism of communicating one's own sensory system information about a task, movement or skill.Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Lenses: Pieces of glass or other transparent materials used for magnification or increased visual acuity.Darkness: The absence of light.Tibet: An autonomous region located in central Asia, within China.Eyeglasses: A pair of ophthalmic lenses in a frame or mounting which is supported by the nose and ears. The purpose is to aid or improve vision. It does not include goggles or nonprescription sun glasses for which EYE PROTECTIVE DEVICES is available.Retinal Cone Photoreceptor Cells: Photosensitive afferent neurons located primarily within the FOVEA CENTRALIS of the MACULA LUTEA. There are three major types of cone cells (red, blue, and green) whose photopigments have different spectral sensitivity curves. Retinal cone cells operate in daylight vision (at photopic intensities) providing color recognition and central visual acuity.Visual Cortex: Area of the OCCIPITAL LOBE concerned with the processing of visual information relayed via VISUAL PATHWAYS.Electroretinography: Recording of electric potentials in the retina after stimulation by light.Genetics, Population: The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.Cross-Cultural Comparison: Comparison of various psychological, sociological, or cultural factors in order to assess the similarities or diversities occurring in two or more different cultures or societies.Visual Pathways: Set of cell bodies and nerve fibers conducting impulses from the eyes to the cerebral cortex. It includes the RETINA; OPTIC NERVE; optic tract; and geniculocalcarine tract.Lighting: The illumination of an environment and the arrangement of lights to achieve an effect or optimal visibility. Its application is in domestic or in public settings and in medical and non-medical environments.Physical Endurance: The time span between the beginning of physical activity by an individual and the termination because of exhaustion.Space Perception: The awareness of the spatial properties of objects; includes physical space.Anoxia: Relatively complete absence of oxygen in one or more tissues.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Feedback: A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.Eye Movements: Voluntary or reflex-controlled movements of the eye.Serial Passage: Inoculation of a series of animals or in vitro tissue with an infectious bacterium or virus, as in VIRULENCE studies and the development of vaccines.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Acoustic Stimulation: Use of sound to elicit a response in the nervous system.Climate: The longterm manifestations of WEATHER. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Geography: The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)Motor Skills: Performance of complex motor acts.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Oxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Neuronal Plasticity: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.Discrimination (Psychology): Differential response to different stimuli.Mechanotransduction, Cellular: The process by which cells convert mechanical stimuli into a chemical response. It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory.Vision, Binocular: The blending of separate images seen by each eye into one composite image.Physical Stimulation: Act of eliciting a response from a person or organism through physical contact.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Osmotic Pressure: The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Kinetics: The rate dynamics in chemical or physical systems.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Transfer (Psychology): Change in learning in one situation due to prior learning in another situation. The transfer can be positive (with second learning improved by first) or negative (where the reverse holds).Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Floods: Sudden onset water phenomena with different speed of occurrence. These include flash floods, seasonal river floods, and coastal floods, associated with CYCLONIC STORMS; TIDALWAVES; and storm surges.Chemotaxis: The movement of cells or organisms toward or away from a substance in response to its concentration gradient.Sodium Chloride: A ubiquitous sodium salt that is commonly used to season food.Hot Temperature: Presence of warmth or heat or a temperature notably higher than an accustomed norm.Gene Flow: The change in gene frequency in a population due to migration of gametes or individuals (ANIMAL MIGRATION) across population barriers. In contrast, in GENETIC DRIFT the cause of gene frequency changes are not a result of population or gamete movement.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Retinal Pigments: Photosensitive protein complexes of varied light absorption properties which are expressed in the PHOTORECEPTOR CELLS. They are OPSINS conjugated with VITAMIN A-based chromophores. Chromophores capture photons of light, leading to the activation of opsins and a biochemical cascade that ultimately excites the photoreceptor cells.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Ecology: The branch of science concerned with the interrelationship of organisms and their ENVIRONMENT, especially as manifested by natural cycles and rhythms, community development and structure, interactions between different kinds of organisms, geographic distributions, and population alterations. (Webster's, 3d ed)Vision, Monocular: Images seen by one eye.Reproduction, Asexual: Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from "parent" cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).Diptera: An order of the class Insecta. Wings, when present, number two and distinguish Diptera from other so-called flies, while the halteres, or reduced hindwings, separate Diptera from other insects with one pair of wings. The order includes the families Calliphoridae, Oestridae, Phoridae, SARCOPHAGIDAE, Scatophagidae, Sciaridae, SIMULIIDAE, Tabanidae, Therevidae, Trypetidae, CERATOPOGONIDAE; CHIRONOMIDAE; CULICIDAE; DROSOPHILIDAE; GLOSSINIDAE; MUSCIDAE; TEPHRITIDAE; and PSYCHODIDAE. The larval form of Diptera species are called maggots (see LARVA).RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Birds: Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.Macaca mulatta: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.Proteome: The protein complement of an organism coded for by its genome.Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Phycomyces: A genus of zygomycetous fungi in the family Mucoraceae, order MUCORALES, forming mycelia having a metallic sheen. It has been used for research on phototropism.Flicker Fusion: The point or frequency at which all flicker of an intermittent light stimulus disappears.Models, Theoretical: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Habituation, Psychophysiologic: The disappearance of responsiveness to a repeated stimulation. It does not include drug habituation.Vision Disparity: The difference between two images on the retina when looking at a visual stimulus. This occurs since the two retinas do not have the same view of the stimulus because of the location of our eyes. Thus the left eye does not get exactly the same view as the right eye.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Locomotion: Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.Behavior, Animal: The observable response an animal makes to any situation.Auditory Perception: The process whereby auditory stimuli are selected, organized, and interpreted by the organism.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Functional Laterality: Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.Antarctic Regions: The continent lying around the South Pole and the southern waters of the Atlantic, Pacific, and Indian Oceans. It includes the Falkland Islands Dependencies. (From Webster's New Geographical Dictionary, 1988, p55)Cochlear Nerve: The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.Mice, Inbred C57BLOcular Physiological Phenomena: Processes and properties of the EYE as a whole or of any of its parts.Color Vision: Function of the human eye that is used in bright illumination or in daylight (at photopic intensities). Photopic vision is performed by the three types of RETINAL CONE PHOTORECEPTORS with varied peak absorption wavelengths in the color spectrum (from violet to red, 400 - 700 nm).Fishes: A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Host-Pathogen Interactions: The interactions between a host and a pathogen, usually resulting in disease.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Heat-Shock Response: A constellation of responses that occur when an organism is exposed to excessive heat. Responses include synthesis of new proteins and regulation of others.Motor Activity: The physical activity of a human or an animal as a behavioral phenomenon.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Glucagon-Like Peptide 2: A 33-amino acid peptide derived from the C-terminal of PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. It stimulates intestinal mucosal growth and decreased apoptosis of ENTEROCYTES. GLP-2 enhances gastrointestinal function and plays an important role in nutrient homeostasis.Fixation, Ocular: The positioning and accommodation of eyes that allows the image to be brought into place on the FOVEA CENTRALIS of each eye.Acids: Chemical compounds which yield hydrogen ions or protons when dissolved in water, whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water (neutralization). An extension of the term includes substances dissolved in media other than water. (Grant & Hackh's Chemical Dictionary, 5th ed)Nitrogen: An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.Seawater: The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Host-Parasite Interactions: The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.Evoked Potentials, Visual: The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.Genetic Speciation: The splitting of an ancestral species into daughter species that coexist in time (King, Dictionary of Genetics, 6th ed). Causal factors may include geographic isolation, HABITAT geometry, migration, REPRODUCTIVE ISOLATION, random GENETIC DRIFT and MUTATION.Homeostasis: The processes whereby the internal environment of an organism tends to remain balanced and stable.Genes, Bacterial: The functional hereditary units of BACTERIA.Host Specificity: The properties of a pathogen that makes it capable of infecting one or more specific hosts. The pathogen can include PARASITES as well as VIRUSES; BACTERIA; FUNGI; or PLANTS.Psychometrics: Assessment of psychological variables by the application of mathematical procedures.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Feeding Behavior: Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals.Visual Fields: The total area or space visible in a person's peripheral vision with the eye looking straightforward.Bacterial Physiological Phenomena: Physiological processes and properties of BACTERIA.Salamandra: A genus of European newts in the Salamandridae family. The two species of this genus are Salamandra salamandra (European "fire" salamander) and Salamandra atra (European alpine salamander).Genetic Drift: The fluctuation of the ALLELE FREQUENCY from one generation to the next.Gene Transfer, Horizontal: The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC).Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Global Warming: Increase in the temperature of the atmosphere near the Earth's surface and in the troposphere, which can contribute to changes in global climate patterns.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.Fossils: Remains, impressions, or traces of animals or plants of past geological times which have been preserved in the earth's crust.Symbiosis: The relationship between two different species of organisms that are interdependent; each gains benefits from the other or a relationship between different species where both of the organisms in question benefit from the presence of the other.Odors: The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)Smell: The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.Head Movements: Voluntary or involuntary motion of head that may be relative to or independent of body; includes animals and humans.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Rhodopsin: A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.Smegmamorpha: Group of fish under the superorder Acanthopterygii, separate from the PERCIFORMES, which includes swamp eels, mullets, sticklebacks, seahorses, spiny eels, rainbowfishes, and KILLIFISHES. The name is derived from the six taxa which comprise the group. (From, 8/4/2000)Diet: Regular course of eating and drinking adopted by a person or animal.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.Form Perception: The sensory discrimination of a pattern shape or outline.Hair Cells, Auditory: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Touch: Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.Urodela: An order of the Amphibia class which includes salamanders and newts. They are characterized by usually having slim bodies and tails, four limbs of about equal size (except in Sirenidae), and a reduction in skull bones.Mechanoreceptors: Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures.Arm: The superior part of the upper extremity between the SHOULDER and the ELBOW.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.TurtlesPlants: Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Deceleration: A decrease in the rate of speed.Population Dynamics: The pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.Anaerobiosis: The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Water-Electrolyte Balance: The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.

*  Physiological adaptations involved in alkane assimilation at a low temperature by Rhodococcus sp. strain Q15.

Abstract We examined physiological adaptations which allow the psychrotroph Rhodococcus sp. strain Q15 to assimilate alkanes at ... Abstract We examined physiological adaptations which allow the psychrotroph Rhodococcus sp. strain Q15 to assimilate alkanes at ... Physiological adaptations involved in alkane assimilation at a low temperature by Rhodococcus sp. strain Q15.. ...

*  Endocrinology | Cambridge University Press

Allostasis, Homeostasis, and the Costs of Physiological Adaptation Schulkin, Jay Published: August 2012Published: October 2004 ... Physiological and Clinical Aspects. Juul, Anders Jorgensen, Jens O. L. Published: June 2000Published: April 2011. 2nd Edition ...

*  "Physiological adaptations and feeding mechanisms of the invasive purpl" by Leesa E. Sorber

I investigated their physiological and morphological adaptations to these conditions. The acute physiological response of the ... Nuttallia obscurata also must have adaptations in feeding structures or strategies to survive in the high intertidal zone where ... I investigated their physiological and morphological adaptations to these conditions. The acute physiological response of the ... Sorber, Leesa E., "Physiological adaptations and feeding mechanisms of the invasive purple varnish clam, Nuttallia obscurata" ( ...

*  Kursus: 2016-2017 Physiological Adaptations to Strength Training - Efter- og videreuddannelse, Københavns Universitet

Physiological Adaptations to Strength Training. Course content. The focus of the course is on the physiological and ... The student demonstrates comprehensive knowledge in relation to physiological adaptations to strength training with special ... Students will gain knowledge of adaptations occurring at the neural, muscular and tendon level as a result of various forms of ... in the assignment the capability to analyze and discuss possible interacting factors and relate physiological adaptations to ...

*  "Tradeoffs of warm adaptation in aquatic ectotherms: Live fast, die young?" by A. P....

In freshwater lakes employed as cooling reservoirs for power plants, increased physiological stress from high water temperature ... This study raises the questions about the causal relationships between physiological performance and habitat temperature, in ... Tradeoffs of warm adaptation in aquatic ectotherms: Live fast, die young?. Comparative Biochemistry and Physiology Part A: ... "Tradeoffs of warm adaptation in aquatic ectotherms: Live fast, die young?" Comparative Biochemistry and Physiology Part A: ...

*  Crop evolution adaptation and yield | Natural resource management, agriculture, horticulture and forestry | Cambridge...

4. Adaptation and the ecology of yield. 5. Physiological aspects of crop improvement. 6. Increases in yield: trends and limits ... In this major work Lloyd Evans provides an integrated view of the domestication, adaptation, and improvement of crop plants, ... The concept of yield is tied to domestication, adaptation, and improvement. Elements of genetic diversity, plant breeding, ...

*  Osmolito - Wikipedia

doi:10.1016/S0091-679X(07)84022-2. Biochemical Adaptation. Mechanism and Process in Physiological Evolution. Oxford: Oxford ... doi:10.1016/s0006-3495(85)83932-1. Csonka LN (1989). «Physiological and genetic responses of bacteria to osmotic stress». ...

*  The relative importance of physiological and behavioral adaptation in diving endotherms: a case study with great cormorants -...

The relative importance of physiological and behavioral adaptation in diving endotherms: a case study with great cormorants. * ...

*  Catalogue 2013-14 : University of Vermont

SOC 020 - Aging: Change & Adaptation. Individual and social meanings of aging and old age; physical, physiological, ... Examines the interaction of cultural, social, psychological, and physiological factors in prohibited drug-taking. Credits: 3.00 ... Comparative examination of sociocultural adaptations to mortality with special attention to family, medical, legal, religious, ... psychological, and sociological changes accompanying aging; individual, family, community, and societal adaptations to aging. ...

*  Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in...

Adaptation, Physiological*. Animals. Arsenites / pharmacology*. Blotting, Northern. Epithelial Cells / drug effects, metabolism ... Next Document: Changes in Borna disease virus genome with adaptation to host.. ...

*  Motor adaptation as a greedy optimization of error and effort

thought of as a process in which the nervous system learns to anticipate the environmental forces to eliminate kinematic error. Here we show that motor adaptation can more generally be modeled as a process in which the motor system greedily minimizes a cost function that is the weighted sum of kinematic error and effort. The learning dynamics predicted by this minimization process are a linear, auto-regressive equation with only one state, which has been identified previously as providing a good fit to data from force-field-type experiments. Thus we provide a new theoretical result that shows how these previously identified learning dynamics can be viewed as arising from an optimization of error and effort. We also show that the coefficients of the learning dynamics must fall within a specific range for the optimization model to be valid and verify with experimental data from walking in a force field that they indeed fall in this range. Finally, we attempted to falsify the model by ...

*  Asynchrony adaptation reveals neural population code for audio-visual timing | Proceedings of the Royal Society of London B:...

After exposure to a consistent temporal delay between auditory and visual stimuli, perceived auditory-visual simultaneity is adjusted to compensate for the adapted lag. Recent proposals that this phenomenon arises as a consequence of changes in perceptual processing latency [21,22] predict a uniform recalibration, in which the perception of all auditory-visual temporal relationships is equally affected. Contrary to this prediction, however, in the present study we have shown that changes in perceived timing induced by asynchrony adaptation vary systematically as a function of the difference between adapted and tested SOAs. This finding is difficult to reconcile with any explanation based on sensory processing changes within either (or both) modalities. Instead, it suggests that asynchrony adaptation acts upon representations of the temporal relationship between auditory and visual inputs itself.. How does the brain represent the relative timing of different sensory inputs? ...

*  US Patent # 6,961,637. On demand adaptive control system -

An adaptive control system and method for controlling the path feed rate to achieve a target spindle load during machine tool operations. The adaptive control system can provide load monitoring capabi

*  Experimental projects | Bioinformatics and Genomics @ CRG

The availability of cheap massive DNA sequencing technology is making it easier to study evolution and ecology on the DNA level in the field. With this in mind we are starting several pilot projects aimed at detecting selection for different adaptations in the field.

*  Solar production prediction based on non linear meteo source adaptation - PDF

Solar production prediction based on non linear meteo source adaptation Mariam Barque,Luc Dufour, Dominique Genoud, Arnaud Zufferey 1 Bruno Ladevie and Jean-Jacques Bezian 2 1 Institute of Information

*  Anomaly Detection and its Adaptation: Studies on Cyber-Physical Systems - PDF

Linköping Studies in Science and Technology Licentiate Thesis No Anomaly Detection and its Adaptation: Studies on Cyber-Physical Systems by Massimiliano Raciti Department of Computer and Information

Maladaptation: A maladaptation () is a trait that is (or has become) more harmful than helpful, in contrast with an adaptation, which is more helpful than harmful. All organisms, from bacteria to humans, display maladaptive and adaptive traits.Avoidance coping: In psychology, avoidance coping, escape coping, or cope and avoid is a maladaptive coping mechanism characterized by the effort to avoid dealing with a stressor. Coping refers to behaviors that attempt to protect oneself from psychological damage.Acclimatization: Acclimatization (UK also acclimatisation; US also acclimation) is the process in which an individual organism adjusts to a gradual change in its environment (such as a change in temperature, humidity, photoperiod, or pH), allowing it to maintain performance across a range of environmental conditions. Acclimation occurs in a short period of time (days to weeks), and within the organism's lifetime (compare to adaptation).Selection (relational algebra): In relational algebra, a selection (sometimes called a restriction to avoid confusion with SQL's use of SELECT) is a unary operation written asTemporal analysis of products: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studyingMolecular evolution: Molecular evolution is a change in the sequence composition of cellular molecules such as DNA, RNA, and proteins across generations. The field of molecular evolution uses principles of evolutionary biology and population genetics to explain patterns in these changes.Branching order of bacterial phyla (Gupta, 2001): There are several models of the Branching order of bacterial phyla, one of these was proposed in 2001 by Gupta based on conserved indels or protein, termed "protein signatures", an alternative approach to molecular phylogeny. Some problematic exceptions and conflicts are present to these conserved indels, however, they are in agreement with several groupings of classes and phyla.Matrix model: == Mathematics and physics ==Grow lightLake MarathonColes PhillipsEvolution in Variable EnvironmentBiological motion: Biological motion is a term used by social and cognitive neuroscientists to refer to the unique visual phenomenon of a moving, animate object. Often, the stimuli used in biological motion experiments are just a few moving dots that reflect the motion of some key joints of the moving organism.Percolation threshold: Percolation threshold is a mathematical concept related to percolation theory, which is the formation of long-range connectivity in random systems. Below the threshold a giant connected component does not exist; while above it, there exists a giant component of the order of system size.Rod cellMakyo: The term is a Zen term that means “ghost cave” or “devil’s cave.” It is a figurative reference to the kind of self-delusion that results from clinging to an experience and making a conceptual “nest” out of it for oneself.Cold shock response: Cold shock response is the physiological response of organisms to sudden cold, especially cold water.Genetic variation: right|thumbKorte's law: In psychophysics, Korte's law, also known more completely as Korte's third law of apparent motion, is an observation relating the phenomenon of apparent motion to the distance and duration between two successively presented stimuli. It was originally proposed in 1915 by Adolf Korte.Silent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Climate change in the United Kingdom: Climate change in the United Kingdom has been a subject of protests and controversies, and various policies have been developed to mitigate its effects. It is estimated to demand at least 80-85% emission reductions in the EU during 2008-2050 with reductions as soon as technically possible.Myokine: A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions.Bente Klarlund Pedersen , Thorbjörn C.Voluntary Parenthood League: The Voluntary Parenthood League (VPL) was an organization that advocated for contraception during the birth control movement in the United States. The VPL was founded in 1919 by Mary Dennett.EcosystemGlobal microbial identifier: The genomic epidemiological database for global identification of microorganisms or global microbial identifier (GMI) is a platform for storing whole genome sequencing (WGS) data of microorganisms, for the identification of relevant genes and for the comparison of genomes to detect and track-and-trace infectious disease outbreaks and emerging pathogens. The database holds two types of information: 1) genomic information of microorganisms, linked to, 2) metadata of those microorganism such as epidemiological details.Canon EOS 5Ferric uptake regulator family: In molecular biology, the ferric uptake regulator (FUR) family of proteins includes metal ion uptake regulator proteins. These are responsible for controlling the intracellular concentration of iron in many bacteria.Saccade: A saccade ( , French for jerk) is quick, simultaneous movement of both eyes between two phases of fixation in the same direction.Cassin, B.Hofstede's cultural dimensions theory: Hofstede's cultural dimensions theory is a framework for cross-cultural communication, developed by Geert Hofstede. It describes the effects of a society's culture on the values of its members, and how these values relate to behavior, using a structure derived from factor analysis.Ventricular action potentialDNA sequencer: A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: G (guanine), C (cytosine), A (adenine) and T (thymine).Mechanochemistry: Mechanochemistry or mechanical chemistry is the coupling of mechanical and chemical phenomena on a molecular scale and includes mechanical breakage, chemical behaviour of mechanically stressed solids (e.g.Phenotype microarray: The phenotype microarray approach is a technology for high-throughput phenotyping of cells.Interval boundary element method: Interval boundary element method is classical boundary element method with the interval parameters.
Short bowel syndromePermissive temperature: The permissive temperature is the temperature at which a temperature sensitive mutant gene product takes on a normal, functional phenotype.http://www.HSD2 neurons: HSD2 neurons are a small group of neurons in the brainstem which are uniquely sensitive to the mineralocorticosteroid hormone aldosterone, through expression of HSD11B2. They are located within the caudal medulla oblongata, in the nucleus of the solitary tract (NTS).Doxanthrine: Doxanthrine is a synthetic compound which is a potent and selective full agonist for the dopamine D1 receptor. Doxanthrine has been shown to be orally active in producing contralateral rotation in the 6-hydroxy-dopamine rat model of Parkinson's disease.Daniel Kane (linguist): Daniel Kane is an Australian linguist, one of the world's foremost authorities on the extinct Jurchen and Khitan languages and their scripts.Robert Thom (translator): Robert Thom (, 1807 – September 14, 1846) was an English nineteenth century Chinese language translator and diplomat based in Canton (modern day Guangzhou) who worked for the trading house Jardine, Matheson & Co. and was seconded to the British armed forces during the First Opium War (1839 – 1842) was a Tel Aviv-based technology company that developed a platform for efficient and accurate facial recognition in photos uploaded via web and mobile applications.Vision in fishes: Vision is an important sensory system for most species of fish. Fish eyes are similar to terrestrial vertebrates like birds and mammals, but have a more spherical lens.Index of energy articles: This is an index of energy articles.Arteriovenous oxygen difference: The arteriovenous oxygen difference, or a-vO2 diff, is the difference in the oxygen content of the blood between the arterial blood and the venous blood. It is an indication of how much oxygen is removed from the blood in capillaries as the blood circulates in the body.Retinal regeneration: Retinal regeneration deals with restoring retinal function to vertebrates so impaired.Micromirror device: Micromirror devices are devices based on microscopically small mirrors. The mirrors are Microelectromechanical systems (MEMS), which means that their states are controlled by applying a voltage between the two electrodes around the mirror arrays.In Secret Tibet: In Secret Tibet (In disguise amongst lamas, robbers, and wise men) is a travel book by author Theodore Illion, first published in English in 1937.Rimless eyeglasses: Rimless eyeglasses, are a type of eyeglasses in which the lenses are mounted directly to the bridge and/or temples. The style is divided into two subtypes: three piece glasses are composed of lenses mounted to a bridge and two separate temple arms, while rimways (also called cortlands) feature a supporting arch that connects the temples to the bridge and provides extra stability for the lenses.Panmixia: Panmixia (or panmixis) means random mating.King C and Stanfield W.Plastic headlight restorationPhysical strength: Strength (physics)}}Hypoxic hypoxia: Hypoxic hypoxia is a result of insufficient oxygen available to the lungs. A blocked airway, a drowning or a reduction in partial pressure (high altitude above 10,000 feet) are examples of how lungs can be deprived of oxygen.Protein primary structure: The primary structure of a peptide or protein is the linear sequence of its amino acid structural units, and partly comprises its overall biomolecular structure. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end.Temporal feedbackSymmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Hadley Centre for Climate Prediction and Research: 140px|rightHealth geography: Health geography is the application of geographical information, perspectives, and methods to the study of health, disease, and health care.Adult interaction with infants: When adults come into contact with infants, it is unlikely that they would be able to have a proper conversation, as the infant would not know enough about pop culture or general knowledge to create a stimulating conversation for the adult. Also, the adult may not understand baby-language and cannot relate to their situation properly.Gene signature: A gene signature is a group of genes in a cell whose combined expression patternItadani H, Mizuarai S, Kotani H. Can systems biology understand pathway activation?Respirometer: A respirometer is a device used to measure the rate of respiration of a living organism by measuring its rate of exchange of oxygen and/or carbon dioxide. They allow investigation into how factors such as age, chemicals or the effect of light affect the rate of respiration.Homeostatic plasticity: In neuroscience, homeostatic plasticity refers to the capacity of neurons to regulate their own excitability relative to network activity, a compensatory adjustment that occurs over the timescale of days. Synaptic scaling has been proposed as a potential mechanism of homeostatic plasticity.

(1/12330) On the neural correlates of visual perception.

Neurological findings suggest that the human striate cortex (V1) is an indispensable component of a neural substratum subserving static achromatic form perception in its own right and not simply as a central distributor of retinally derived information to extrastriate visual areas. This view is further supported by physiological evidence in primates that the finest-grained conjoined representation of spatial detail and retinotopic localization that underlies phenomenal visual experience for local brightness discriminations is selectively represented at cortical levels by the activity of certain neurons in V1. However, at first glance, support for these ideas would appear to be undermined by incontrovertible neurological evidence (visual hemineglect and the simultanagnosias) and recent psychophysical results on 'crowding' that confirm that activation of neurons in V1 may, at times, be insufficient to generate a percept. Moreover, a recent proposal suggests that neural correlates of visual awareness must project directly to those in executive space, thus automatically excluding V1 from a related perceptual space because V1 lacks such direct projections. Both sets of concerns are, however, resolved within the context of adaptive resonance theories. Recursive loops, linking the dorsal lateral geniculate nucleus (LGN) through successive cortical visual areas to the temporal lobe by means of a series of ascending and descending pathways, provide a neuronal substratum at each level within a modular framework for mutually consistent descriptions of sensory data. At steady state, such networks obviate the necessity that neural correlates of visual experience project directly to those in executive space because a neural phenomenal perceptual space subserving form vision is continuously updated by information from an object recognition space equivalent to that destined to reach executive space. Within this framework, activity in V1 may engender percepts that accompany figure-ground segregations only when dynamic incongruities are resolved both within and between ascending and descending streams. Synchronous neuronal activity on a short timescale within and across cortical areas, proposed and sometimes observed as perceptual correlates, may also serve as a marker that a steady state has been achieved, which, in turn, may be a requirement for the longer time constants that accompany the emergence and stability of perceptual states compared to the faster dynamics of adapting networks and the still faster dynamics of individual action potentials. Finally, the same consensus of neuronal activity across ascending and descending pathways linking multiple cortical areas that in anatomic sequence subserve phenomenal visual experiences and object recognition may underlie the normal unity of conscious experience.  (+info)

(2/12330) Trans-synaptically induced bursts in regular spiking non-pyramidal cells in deep layers of the cat motor cortex.

In deep layers of the cat motor cortex, we have investigated the properties of neurons displaying trans-synaptically induced bursts. In in vivo experiments, extracellularly recorded burst neurons were separated into two subtypes based on their dependence on stimulation sites, the medullary pyramid or the ventrolateral (VL) thalamic nucleus, from which bursts of 10-20 spikes were triggered. The spike amplitude attenuation and frequency adaptation during a burst were more prominent in pyramid-dependent burst neurons than in VL-dependent burst neurons. Intracellular recordings in in vivo experiments revealed that pyramid-dependent bursts emerged from a long-lasting depolarization, while each spike during a VL-dependent burst was narrow in half-width and was followed by a fast AHP, similar to fast spiking neurons. In in vitro slice experiments, intracellular recordings were obtained from neurons that displayed a burst of attenuated spikes emerging from a long-lasting depolarization, and were also obtained from fast spiking neurons. They were morphologically recovered to be multipolar cells with sparsely spiny dendrites and local axonal networks, suggesting that they are inhibitory interneurons. The multipolar neurons displaying bursts of attenuated spikes may mediate the recurrent inhibition of pyramidal tract cells.  (+info)

(3/12330) Lysine deficiency alters diet selection without depressing food intake in rats.

Under states of protein deficiency, the dietary limiting amino acid, rather than protein content, can act as the dietary stimulus to control diet selection. If fact, threonine-deficient rats will alter their diet selection patterns solely on the basis of very small changes (0.009 g/100 g) in the dietary threonine concentration. In these studies, we assessed whether lysine-deficient rats will also alter their diet selection patterns on the basis of small changes in dietary Lys concentration. In all experiments, growing rats were adapted to diets in which the protein fraction (purified amino acids or wheat gluten) was limiting in Lys. They were then given a choice between the adaptation diet (AD) diet and a slightly more deficient diet. Rats that were adapted to a Lys-deficient diet (0.25 g Lys/100 g) selected their AD over diets containing as little as 0.01% less Lys (P < 0.01) within 5 d. To determine how deficient rats must be before they alter their selection patterns, rats were adapted to diets containing various levels of Lys, i.e., 2 levels below the requirement for growth and 2 levels above the requirement for growth, but below the requirement for maximal nitrogen retention. Only rats adapted to diets containing Lys below their requirement for growth selected their AD over a diet containing 0.05% less Lys (P < 0.005). Finally, to determine whether rats will alter their selection to whole protein-based diets, rats were adapted to 25% wheat gluten diets supplemented with 0.03-0.21% Lys. Rats selected the AD over a diet containing as little as 0.09% less supplemental Lys by d 4 of the trial (P < 0.05). We conclude that rats are sensitive to changes as small as 0.01% in dietary Lys concentration, but that sensitivity requires prior adaptation to Lys-deficient diets.  (+info)

(4/12330) Changes in protein tyrosine phosphorylation in the rat brain after cerebral ischemia in a model of ischemic tolerance.

A brief period of sublethal cerebral ischemia, followed by several days of recovery, renders the brain resistant to a subsequent lethal ischemic insult, a phenomenon termed ischemic preconditioning or tolerance. Ischemic tolerance was established in the rat two-vessel occlusion model of ischemia, induced by occlusion of both carotid arteries in combination with hypotension. Ischemic preconditioning (3 minutes) provided maximal neuroprotection when induced 2 days prior to a lethal ischemic insult of 9-minute duration. Neuroprotection persisted for at least 8 weeks. Since neurotransmission has been implicated in ischemic cell death, the effect of ischemic preconditioning on tyrosine phosphorylation of proteins and on the levels of glutamate receptor subunits in hippocampus and neocortex was studied. Regional levels of tyrosine phosphorylation of proteins in general and the N-methyl-D-aspartate receptor subunit NR2 in particular are markedly enhanced after ischemia in nonconditioned brains, in both the synaptosomal fraction and the whole-tissue homogenate of rat neocortex and hippocampus, but recover to control levels only in the preconditioned brain. Ischemic preconditioning selectively induces a decrease in the levels of the NR2A and NR2B subunits and a modest decrease in the levels of NR1 subunit proteins in the synaptosomal fraction of the neocortex but not hippocampus after the second lethal ischemia. It was concluded that ischemic preconditioning prevents a persistent change in cell signaling as evidenced by the tyrosine phosphorylation of proteins after the second lethal ischemic insult, which may abrogate the activation of detrimental cellular processes leading to cell death.  (+info)

(5/12330) Fibrocartilage in tendons and ligaments--an adaptation to compressive load.

Where tendons and ligaments are subject to compression, they are frequently fibrocartilaginous. This occurs at 2 principal sites: where tendons (and sometimes ligaments) wrap around bony or fibrous pulleys, and in the region where they attach to bone, i.e. at their entheses. Wrap-around tendons are most characteristic of the limbs and are commonly wider at their point of bony contact so that the pressure is reduced. The most fibrocartilaginous tendons are heavily loaded and permanently bent around their pulleys. There is often pronounced interweaving of collagen fibres that prevents the tendons from splaying apart under compression. The fibrocartilage can be located within fascicles, or in endo- or epitenon (where it may protect blood vessels from compression or allow fascicles to slide). Fibrocartilage cells are commonly packed with intermediate filaments which could be involved in transducing mechanical load. The ECM often contains aggrecan which allows the tendon to imbibe water and withstand compression. Type II collagen may also be present, particularly in tendons that are heavily loaded. Fibrocartilage is a dynamic tissue that disappears when the tendons are rerouted surgically and can be maintained in vitro when discs of tendon are compressed. Finite element analyses provide a good correlation between its distribution and levels of compressive stress, but at some locations fibrocartilage is a sign of pathology. Enthesis fibrocartilage is most typical of tendons or ligaments that attach to the epiphyses of long bones where it may also be accompanied by sesamoid and periosteal fibrocartilages. It is characteristic of sites where the angle of attachment changes throughout the range of joint movement and it reduces wear and tear by dissipating stress concentration at the bony interface. There is a good correlation between the distribution of fibrocartilage within an enthesis and the levels of compressive stress. The complex interlocking between calcified fibrocartilage and bone contributes to the mechanical strength of the enthesis and cartilage-like molecules (e.g. aggrecan and type II collagen) in the ECM contribute to its ability to withstand compression. Pathological changes are common and are known as enthesopathies.  (+info)

(6/12330) Small conductance potassium channels cause an activity-dependent spike frequency adaptation and make the transfer function of neurons logarithmic.

We made a computational model of a single neuron to study the effect of the small conductance (SK) Ca2+-dependent K+ channel on spike frequency adaptation. The model neuron comprised a Na+ conductance, a Ca2+ conductance, and two Ca2+-independent K+ conductances, as well as a small and a large (BK) Ca2+-activated K+ conductance, a Ca2+ pump, and mechanisms for Ca2+ buffering and diffusion. Sustained current injection that simulated synaptic input resulted in a train of action potentials (APs) which in the absence of the SK conductance showed very little adaptation with time. The transfer function of the neuron was nearly linear, i.e., both asymptotic spike rate as well as the intracellular free Ca2+ concentration ([Ca2+]i) were approximately linear functions of the input current. Adding an SK conductance with a steep nonlinear dependence on [Ca2+]i (. Pflugers Arch. 422:223-232; Kohler, Hirschberg, Bond, Kinzie, Marrion, Maylie, and Adelman. 1996. Science. 273:1709-1714) caused a marked time-dependent spike frequency adaptation and changed the transfer function of the neuron from linear to logarithmic. Moreover, the input range the neuron responded to with regular spiking increased by a factor of 2.2. These results can be explained by a shunt of the cell resistance caused by the activation of the SK conductance. It might turn out that the logarithmic relationships between the stimuli of some modalities (e.g., sound or light) and the perception of the stimulus intensity (Fechner's law) have a cellular basis in the involvement of SK conductances in the processing of these stimuli.  (+info)

(7/12330) Chemotactic responses of Escherichia coli to small jumps of photoreleased L-aspartate.

Computer-assisted motion analysis coupled to flash photolysis of caged chemoeffectors provides a means for time-resolved analysis of bacterial chemotaxis. Escherichia coli taxis toward the amino acid attractant L-aspartate is mediated by the Tar receptor. The physiology of this response, as well as Tar structure and biochemistry, has been studied extensively. The beta-2, 6-dinitrobenzyl ester of L-aspartic acid and the 1-(2-nitrophenyl)ethyl ether of 8-hydroxypyrene-1,3,6-tris-sulfonic acid were synthesized. These compounds liberated L-aspartate and the fluorophore 8-hydroxypyrene 1,3,6-tris-sulfonic acid (pyranine) upon irradiation with near-UV light. Photorelease of the fluorophore was used to define the amplitude and temporal stability of the aspartate jumps employed in chemotaxis experiments. The dependence of chemotactic adaptation times on aspartate concentration, determined in mixing experiments, was best fit by two Tar aspartate-binding sites. Signal processing (excitation) times, amplitudes, and adaptive recovery of responses elicited by aspartate jumps producing less than 20% change in receptor occupancy were characterized in photorelease assays. Aspartate concentration jumps in the nanomolar range elicited measurable responses. The response threshold and sensitivity of swimming bacteria matched those of bacteria tethered to glass by a single flagellum. Stimuli of similar magnitude, delivered either by rapid mixing or photorelease, evoked responses of similar strength, as assessed by recovery time measurements. These times remained proportional to change in receptor occupancy close to threshold, irrespective of prior occupancy. Motor excitation responses decayed exponentially with time. Rates of excitation responses near threshold ranged from 2 to 7 s-1. These values are consistent with control of excitation signaling by decay of phosphorylated pools of the response regulator protein, CheY. Excitation response rates increased slightly with stimulus size up to values limited by the instrumentation; the most rapid was measured to be 16 +/- 3 (SE) s-1. This increase may reflect simultaneous activation of CheY dephosphorylation, together with inhibition of its phosphorylation.  (+info)

(8/12330) Impact of vascular adaptation to chronic aortic regurgitation on left ventricular performance.

BACKGROUND: This investigation was designed to test the hypothesis that vascular adaptation occurs in patients with chronic aortic regurgitation to maintain left ventricular (LV) performance. METHODS AND RESULTS: Forty-five patients with chronic aortic regurgitation (mean age 50+/-14 years) were studied using a micromanometer LV catheter to obtain LV pressures and radionuclide ventriculography to obtain LV volumes during multiple loading conditions and right atrial pacing. These 45 patients were subgrouped according to their LV contractility (Ees) and ejection fraction values. Group I consisted of 24 patients with a normal Ees. Group IIa consisted of 10 patients with impaired Ees values (Ees <1.00 mm Hg/mL) but normal LV ejection fractions; Group IIb consisted of 11 patients with impaired contractility and reduced LV ejection fractions. The left ventricular-arterial coupling ratio, Ees/Ea, where Ea was calculated by dividing the LV end-systolic pressure by LV stroke volume, averaged 1.60+/-0.91 in Group I. It decreased to 0.91+/-0.27 in Group IIa (P<0.05 versus Group I), and it decreased further in Group IIb to 0.43+/-0.24 (P<0.001 versus Groups I and IIa). The LV ejection fractions were inversely related to the Ea values in both the normal and impaired contractility groups (r=-0.48, P<0.05 and r=-0.56, P<0.01, respectively), although the slopes of these relationships differed (P<0.05). The average LV work was maximal in Group IIa when the left ventricular-arterial coupling ratio was near 1.0 because of a significant decrease in total arterial elastance (P<0.01 versus Group I). In contrast, the decrease in the left ventricular-arterial coupling ratio in Group IIb was caused by an increase in total arterial elastance, effectively double loading the LV, contributing to a decrease in LV pump efficiency (P<0.01 versus Group IIa and P<0.001 versus Group I). CONCLUSIONS: Vascular adaptation may be heterogeneous in patients with chronic aortic regurgitation. In some, total arterial elastance decreases to maximize LV work and maintain LV performance, whereas in others, it increases, thereby double loading the LV, contributing to afterload excess and a deterioration in LV performance that is most prominent in those with impaired contractility.  (+info)

morphological adaptations

  • I investigated their physiological and morphological adaptations to these conditions. (
  • The focus of the course is on the physiological and morphological adaptations accompanying strength training. (


  • These performance improvements were mediated through neuromuscular adaptations specific to the training stimulus. (
  • Kitesurfing activities result in proportionate adaptations in the dynamic equilibrium of athletes، maybe in function of adaptations in the neuromuscular structure، resulting in a better performance in situations that cause disequilibrium. (


  • This study raises the questions about the causal relationships between physiological performance and habitat temperature, in particular how thresholds in an organism's physiology may modulate their community structure, and consequently their ecological success. (
  • In this major work Lloyd Evans provides an integrated view of the domestication, adaptation, and improvement of crop plants, bringing together genetic diversity, plant breeding, physiology, and aspects of agronomy. (


  • The acute physiological response of the invasive, N. obscurata and the native, L. staminea's excised gill tissue's respiratory metabolism (measured as oxygen consumption) in 5, 30, and 55 ppt salinities were measured in a closed system, Gilson Differential Respirometer and compared. (
  • These molecular changes will affect metabolism at tissue and whole animal levels so that physiological processes can proceed at a constant or near constant rate, despite pronounced temperature fluctuations. (

Athletic Performance

  • Adaptations in athletic performance after ballistic power versus strength training. (
  • PURPOSE: To determine whether the magnitude of improvement in athletic performance and the mechanisms driving these adaptations differ in relatively weak individuals exposed to either ballistic power training or heavy strength training. (


  • Main focus is on changes in muscle and tendon morphology, on cellular adaptations and the underlying molecular mechanisms. (
  • Another primary focus is on neural adaptations and the underlying mechanisms. (
  • Emphasis is placed on the physiological significance and underlying molecular mechanisms. (
  • The student demonstrates comprehensive knowledge in relation to physiological adaptations to strength training with special focus on the mechanisms underlying muscle hypertrophy and neural adaptations. (


  • Mechanism and Process in Physiological Evolution. (


  • Student will develop skills in analyzing and presenting scientific papers and problems with the aim of evaluating physiological relevance, study design, results, conclusions and perspectives. (


  • In vitro data clearly demonstrate the importance of shear stress as a potential mechanism underlying vascular adaptations associated with exercise. (


  • Examines the interaction of cultural, social, psychological, and physiological factors in prohibited drug-taking. (


  • Physiological adaptations involved in alkane assimilation at a low temperature by Rhodococcus sp. (
  • In freshwater lakes employed as cooling reservoirs for power plants, increased physiological stress from high water temperature can lead to an increase in mortality, reduce growth, and potentially alter the community structure of fishes. (


  • Students will gain knowledge of the relationship between adaptations, function, specificity and performance. (


  • The student demonstrates in the assignment the capability to analyze and discuss possible interacting factors and relate physiological adaptations to functional changes. (
  • Changes in Borna disease virus genome with adaptation to host. (


  • Students will gain knowledge of adaptations occurring at the neural, muscular and tendon level as a result of various forms of strength training. (


  • Nuttallia obscurata also must have adaptations in feeding structures or strategies to survive in the high intertidal zone where there is limited food availability during exposure at low tide. (


  • Military family adaptation to United Nations Operations in Somalia. (


  • The concept of yield is tied to domestication, adaptation, and improvement. (