*  Does osteofibrous dysplasia progress to adamantinoma and how should they be treated? | The Bone & Joint Journal

Complete data were available for 73 patients (42 with OFD; ten with an OFD-like adamantinoma and 21 with an adamantinoma). The ... No patients with either OFD or an OFD-like adamantinoma developed metastases or had progression to adamantinoma. All patients ... Resection with clear margins is required for patients with adamantinoma. Late tumour recurrence is not uncommon in adamantinoma ... Does osteofibrous dysplasia progress to adamantinoma and how should they be treated?. D. W. Scholfield, Z. Sadozai, C. Ghali, V ...

*  Osteofibrous dysplasia and adamantinoma: correlation of proto-oncogene product and matrix protein expression. - Nuffield...

E-, P-, and N-cadherin expression was found in all cases of classical adamantinoma, but not in differentiated adamantinoma or ... The results show common expression of a number of oncoproteins and bone matrix proteins in adamantinoma and OFD, some of which ... Differential expression of a number of bone matrix protein in adamantinoma may also be of diagnostic use in distinguishing ... These findings would be in keeping with the hypothesis that OFD represents a precursor lesion of adamantinoma. ...

*  GMS | 54. Jahrestagung der Norddeutschen Orthopädenvereinigung e. V. | Adamantinoma of typical and atypical localisation

Only a few cases of Adamantinomas at the short bones, and only one additional case of an Adamantinoma at the metatarsals (Van ... The current management in both cases suggest, that in adamantinoma a wide en-bloc resection of the tumor is effective in local ... The diagnostic work-up including biopsy revealed in both patients an adamantinoma. In the younger female the 4th and 5th ...

*  Anagrams of adamantinoma: with Anagram Expert, find all anagrams of words, names or sentences.

ADAMANTINOMA : 12 characters. Anagrams of "adamantinoma" with 12 characters :. *adamantinoma. - adamantinoma - Scrabble : 15 ... Anagrams of "adamantinoma" with 10 characters :. *adamantoma. - adamantinoma - rest "in". - Scrabble : 13 ... Anagrams of "adamantinoma" with 9 characters :. *anammonid. - adamantinoma - rest "aat". - Scrabble : 12 ... Anagrams of "adamantinoma" with 8 characters :. *adnation. - adamantinoma - rest "aamm". - Scrabble : 9 ...

*  Bone Sarcomas

Adamantinoma. Adamantinoma of the long bones, or extragnathic adamantinoma, is an extremely rare, slow growing, low-grade ...

*  Peginterferon Alfa-2b in Treating Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery -...

Adamantinoma. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms. Neoplasms, ...

*  Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors -...

Adamantinoma. Rhabdoid Tumor. Choroid Plexus Neoplasms. Optic Nerve Glioma. Pinealoma. Spinal Cord Neoplasms. Germinoma. ...
https://clinicaltrials.gov/ct2/show/NCT01076530?cond="hereditary paraganglioma-pheochromocytoma" OR "Paraganglioma"&rank=19

*  Prospective Study of Children and Adolescents With Craniopharyngioma

Adamantinoma. *Obesity. .map{width:100%;height:300px;margin-bottom:15px;} Name. Location. ...

*  Ossifying fibroma | Radiology Reference Article | Radiopaedia.org

adamantinoma: may share a common origin with ossifying fibromas. *osteoid osteoma. *Osteofibrous dysplasia ...

*  Webpathology.com: A Collection of Surgical Pathology Images

Adamantinoma 1 slides. Metastatic Lesions 0 slides. Bone Tumors - II. Fibrous Histiocytoma 1 slides. Fibrosarcoma 1 slides. ...

*  Webpathology.com: A Collection of Surgical Pathology Images

Adamantinoma 1 slides Metastatic Lesions 0 slides. /***** Case of the Month *****/ .cotm-img{} .cotm-content{text-align:left; ...

*  Search Healthwise documents - Asante

Adamantinoma National Organization for Rare Disorders * Adams Oliver Syndrome National Organization for Rare Disorders ...

*  Giant cell tumour of bone | Radiology Reference Article | Radiopaedia.org

adamantinoma of long bones. * enostosis (bone island). * exostosis*subungual exostosis. *osteoid osteoma ...

*  Liposclerosing myxofibrous tumour | Radiology Reference Article | Radiopaedia.org

adamantinoma of long bones. * enostosis (bone island). * exostosis*subungual exostosis. *osteoid osteoma ...

*  Multilocular cyst, jaw | definition of multilocular cyst, jaw by Medical dictionary

adamantinoma.. ameloblastoma, acanthomatous,. n a type that differs from the simple form in that the central cells within the ... Adamantinoma A locally-aggressive, but almost invariably benign tumor that arises from the odontogenic epithelium in a fibrous ... a locally invasive, highly destructive tumor of the jaw; called also adamantinoma. ...
medical-dictionary.thefreedictionary.com/multilocular cyst, jaw

*  Kaori Kameyama

Adamantinoma arising in the femur is extremely rare. We report a case of an adamantinoma occurring in the right medial femoral ... Adamantinoma of the distal femur diagnosed 5 years after initial surgery: a case report. Kai Cao. Department of Orthopedic ...

*  Skeletal symptoms - RightDiagnosis.com

Adamantinoma ... bone pain*Adams-Oliver Syndrome ... short toes*Adducted thumb syndrome recessive form ... sunken chest, ...

*  Conditions listing symptom: Pain - Letter A - RightDiagnosis.com

Adamantinoma - bone pain *Addington disease - headache *Addison's Disease - leg pain *Addisonian crisis - leg pain *Adenine ...

*  Program Areas

By keeping in touch with us and intuitively providing us with the information we need to know, ICAN is truly the best 'coach' imaginable... As a result, we have been able to express our questions to our oncology team in a compelling manner. Cheers to ICAN - here's to life, to hope, and to vitality!'. ...

*  Cytokeratin 8 (KRT8) Antibody - With BSA and Azide - Mouse Monoclonal Antibody [Clone SPM192 ] IHC-P, IF, FC - Buy Now! |Abgent

Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with ...

*  The Radiology Assistant : Bone tumor - Systematic approach and Differential diagnosis

Adamantinoma. tibia shaft, mandible*. Chondroblastoma femur, humerus, tibia, tarsal bone (calc), patella* ...

*  Browse by UCL Departments and Centres - UCL Discovery

Podoplanin expression in adamantinoma of long bones and osteofibrous dysplasia. Virchows Arch , 459 (1) pp. 41-46. 10.1007/ ...

*  Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Borbas, P; Leithner, A; Sadoghi, P; Berndt, A; Liegl, B; Haas, OA Clonality assessment in a case of multifocal adamantinoma and ...

(1/12) Allograft reconstruction for bone sarcoma of the tibia in the growing child.

The outcome of tibial allograft reconstruction after resection of a tumour is inconsistent and has a high rate of failure. There are few reports on the use of tibial allografts in children with open growth plates. We performed 21 allograft reconstructions (16 osteoarticular, five intercalary) in 19 consecutive patients between seven and 17 years of age. Two had Ewing's sarcoma, one an adamantinoma and 16 osteosarcoma, one with multifocal disease. Five patients have died; the other 14 were free from disease at the time of follow-up. Six surviving patients (eight allograft reconstructions) continue to have good or excellent function at a mean of 59 months (14 to 132). One patient has poor function at 31 months. The other seven patients have a good or excellent function after additional procedures including exchange of the allograft and resurfacing or revision to an endoprosthesis at a mean of 101 months (43 to 198). The additional operations were performed at a mean of 47 months (20 to 84) after the first reconstruction. With the use of allograft reconstruction in growing children, joints and growth plates may be preserved, at least partially. Although our results remain inconsistent, tibial allograft reconstruction in selected patients may restore complete and durable function of the limb.  (+info)

(2/12) A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature.

Adamantinoma is known as a low-grade malignant biphasic tumor. Classic adamantinoma is in general characterized by admixture of both epithelial and osteofibrous components that are associated with various proportions and differentiation patterns. Osteofibrous dysplasia (OFD) is a self-limited benign fibro-osseous lesion of bone during infancy and childhood. OFD-like adamantinoma is characterized by predominance of osteofibrous tissues, in which small groups of epithelial cells are only detected by careful search or immunohistochemistry. There have been controversies as to the potential correlation among OFD, OFD-like adamantinoma and classic adamantinoma. We report an unusual case of adamantinoma arising in the tibia, with an extensive review of the literature. The present findings suggest a direct correlation between OFD-like adamantinoma and classic adamantinoma. At the age of 12 years, the tibial biopsy lesion was diagnosed as OFD. At the age of 23, the lesion became larger and more destructive on x-ray films. The biopsy lesion was diagnosed as classic adamantinoma. Wide excision was performed. The primary lesion was retrospectively diagnosed as OFD-like adamantinoma because of presence of keratin-positive epithelial cells within the stroma. At five years after surgery, the patient was free from recurrence or metastasis. The retrospective histological findings of OFD-like adamantinoma in the original biopsy and of a classic adamantinoma in all sections of the later resection specimen raised the possibility of an unusual progression of OFD-like adamantinoma to a classic adamantinoma. The present case and the literature review suggest that an OFD-like adamantinoma may be a precursor lesion of classic adamantinoma. Therefore, the possibility of progression of OFD-like adamantinoma to a classic adamantinoma should be kept in mind, particularly when the destructive changes are seen radiologically.  (+info)

(3/12) Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach?

Osteofibrous dysplasia is an unusual developmental condition of childhood, which almost exclusively affects the tibia. It is thought to follow a slowly progressive course and to stabilise after skeletal maturity. The possible link with adamantinoma is controversial and some authors believe that they are part of one histological process. We retrospectively reviewed 16 patients who were diagnosed as having osteofibrous dysplasia initially or on the final histological examination. Their management was diverse, depending on the severity of symptoms and the extent of the lesion. Definitive (extraperiosteal) surgery was localised "shark-bite" excision for small lesions in five patients. Extensive lesions were treated by segmental excision and fibular autograft in six patients, external fixation and bone transport in four and proximal tibial replacement in one. One patient who had a fibular autograft required further excision and bone transport for recurrence. Six initially underwent curettage and all had recurrence. There were no recurrences after localised extraperiosteal excision or bone transport. There were three confirmed cases of adamantinoma. The relevant literature is reviewed. We recommend extraperiosteal excision in all cases of osteofibrous dysplasia, with segmental excision and reconstruction in more extensive lesions.  (+info)

(4/12) Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report.

We treated a case with left tibial adamantinoma by use of a contralateral fibular osteoadiposal flap. The donor site of conventional fibular osteocutaneous flap must be covered with a skin graft because if we close the donor skin defect directly, compartment syndrome might occur. We were able to close the donor skin defect because this combined type flap included only a small monitoring skin paddle. We present herein the utility of the osteoadiposal flap and show the value of a skin-sparing approach with a minimal aesthetic defect.  (+info)

(5/12) Preliminary report of expression of bax in oral cavity pathologies.

Bax is considered one of major effectors of apoptosis--programmed cell death. Immunohistochemical analysis of in vitro patterns of bax expression was mostly investigated in mammalian cell lines and tissues. The present study is the first in vivo molecular analysis of bax expression in oral cavity pathologies. The study population consisted of 45 patients with hyperplasia, neoplasm in situ malignancy, and carcinoma. Biopsies were taken from incision line, tumour section, and healthy tissue. bax expression was investigated depending on the site of biopsy material sampling and final histopathology result. No statistically significant difference was demonstrated in bax expression between four hyperplasia subgroups. However, statistically significant differences in bax expression were found between the three basic study groups (P = 0.001). Statistically significant differences in bax expression were demonstrated depending on tissue collection site (P = 0.0002). We conclude that differences in bax expression may play a role in the pathogenesis of neoplastic disease.  (+info)

(6/12) Adamantinoma of the tibia with late skeletal metastasis: an unusual presentation.

Adamantinoma is a rare tumour of long bones that occurs most commonly in the tibia. Its pathogenesis is unknown. It is locally aggressive and recurrences are common after resection. Metastases have been reported in 10% to 20% of cases, most commonly in the lungs and rarely in the lymph nodes. We report a patient who developed a skeletal metastasis four years after resection of the primary tumour. There was no evidence of recurrence at the primary site or of secondary deposits in the lungs.  (+info)

(7/12) Treatment of osteofibrous dysplasia and associated lesions.

PURPOSE: To report long term treatment outcomes of osteofibrous dysplasia and association with adamantinoma. PATIENTS AND METHODS: From January 1984 to July 2001, 14 patients with osteofibrous dysplasia were followed for an average of 108 months (78 to 260 months). Our patient group consisted of 6 men and 8 women, with a mean age of 13.9 years (2 to 65 years). We reviewed the clinical and pathological features of all 14 patients. RESULTS: Thirteen patients had a lesion in the tibia, while one patient had lesions in both the tibia and the fibula. Initial treatments were observation after biopsy (6 patients), curettage with or without a bone graft (3 patients), resection followed by a free vascularized fibular bone graft (4 patients), or resection and regeneration with the Ilizarov external fixation (1 patient). Curettage was performed on 6 patients due to recurrence or progression after the initial treatment. Among these patients, one was diagnosed with AD from the biopsy of the recurrent lesion. This patient was further treated by segmental resection and pasteurization. After the initial pathology slides of the 13 patients were reviewed with immunohistochemical cytokeratin staining, one patient diagnosis was changed from osteofibrous dysplasia to osteofibrous dysplasia-like adamantinoma. CONCLUSION: Some patients with osteofibrous dysplasia require close observation because of the high association risk between osteofibrous dysplasia and adamantinoma, Immunohistochemical staining may be helpful in differentiating these two diagnoses.  (+info)

(8/12) Analysis of stromal cells in osteofibrous dysplasia and adamantinoma of long bones.


osteofibrous dysplasia

  • Does osteofibrous dysplasia progress to adamantinoma and how should they be treated? (boneandjoint.org.uk)
  • Aims The aim of this study was to identify any progression between benign osteofibrous dysplasia (OFD), OFD-like adamantinoma and malignant adamantinoma, and to investigate the rates of local recurrence, metastases and survival, in order to develop treatment algorithms for each. (boneandjoint.org.uk)
  • Osteofibrous dysplasia and adamantinoma: correlation of proto-oncogene product and matrix protein expression. (ox.ac.uk)
  • To investigate the relationship between osteofibrous dysplasia (OFD) and adamantinoma, we analyzed the expression of several proto-oncogene products and extracellular matrix proteins by immunohistochemistry and correlated our results with histological and ultrastructural findings. (ox.ac.uk)


  • Differential expression of a number of bone matrix protein in adamantinoma may also be of diagnostic use in distinguishing these 2 lesions immunohistochemically. (ox.ac.uk)


  • The results show common expression of a number of oncoproteins and bone matrix proteins in adamantinoma and OFD, some of which are associated with mesenchymal-to-epithelial cell transformation. (ox.ac.uk)


  • A total of six patients initially diagnosed with OFD were subsequently found to have OFD-like adamantinoma. (boneandjoint.org.uk)
  • Conclusion We found no evidence of progression from OFD to adamantinoma. (boneandjoint.org.uk)
  • E-, P-, and N-cadherin expression was found in all cases of classical adamantinoma, but not in differentiated adamantinoma or OFD. (ox.ac.uk)