Surgical repair of hip abductors. A new technique using Graft Jacket allograft acellular human dermal matrix. (1/15)
(+info)Regeneration of mature dermis by transplanted particulate acellular dermal matrix in a rat model of skin defect wound. (2/15)
(+info)A new in vitro invasion model for oral cancer using an acellular allogenic dermal matrix (Alloderm): the relationship among in vitro invasion activity, in vivo invasion and metastasis. (3/15)
The purpose of this study was to develop a new in vitro model of cancer invasion using a human dermal equivalent, AlloDerm(R). A squamous cell carcinoma line (HSC-2, HSC-3 and OSC20) and a malignant melanoma line (G361) were cultured on AlloDerm(R) and evaluated histologically to examine destruction of the basement membrane and invasion into the dermis of AlloDerm(R). HSC-3 and G361 cells invaded through the basement membrane of AlloDerm(R) at 21-28 days after seeding, while HSC-2 and OSC20 cells did not. Next, these cells were transplanted into the tongues of nude mice, and the degree of local invasiveness was examined histologically. HSC-3 and G361 cells invaded diffusely to the surrounding tongue tissue, although HSC-2 and OSC20 showed only expansive growth. Further, these cells were transplanted subcutaneously in nude mice to study metastatic activity. Regional and distant metastases were rarely observed after transplantation of HSC-2 and OSC20 cells. On the other hand, HSC-3 and G361 cells frequently metastasized. These findings show a close relationship among in vitro invasiveness on AlloDerm(R), in vivo invasiveness, and metastatic activity. This experimental model using AlloDerm(R) is a potentially new in vitro model of cancer invasion. (+info)Closure of the abdominal wall with acellular dermal allograft in intestinal transplantation. (4/15)
(+info)Confocal laser scanning microscopy evaluation of an acellular dermis tissue transplant (Epiflex(R)). (5/15)
(+info)The use of acellular dermal matrices in two-stage expander/implant reconstruction: a multicenter, blinded, randomized controlled trial. (6/15)
(+info)Allograft dermal matrix hiatoplasty during laparoscopic primary fundoplication, paraesophageal hernia repair, and reoperation for failed hiatal hernia repair. (7/15)
(+info)Foreign body reaction to acellular dermal matrix allograft in biologic glenoid resurfacing. (8/15)
(+info)Acellular dermis is a type of processed connective tissue graft used in surgical procedures, particularly in reconstructive surgery. It is derived from human or animal skin, but has had the epidermis and cells of the dermis removed, leaving behind the intact extracellular matrix (ECM). This ECM includes proteins such as collagen and elastin, which provide structural support, and growth factors, which can help to stimulate tissue regeneration.
The acellular nature of the graft means that it is less likely to be rejected by the recipient's immune system, making it a useful option for patients who may not be good candidates for autografts (tissue transplanted from another part of their own body) or allografts (tissue transplanted from another person). Acellular dermis can be used to repair and rebuild damaged skin, as well as to augment soft tissue in areas such as the face and breast.
There are several different brands and types of acellular dermis available, each with its own specific composition and indications for use. Some common examples include AlloDerm, FlexHD, and Integra Dermal Regeneration Template. The choice of graft may depend on factors such as the size and location of the defect being treated, as well as the patient's individual needs and medical history.
The dermis is the layer of skin located beneath the epidermis, which is the outermost layer of the skin. It is composed of connective tissue and provides structure and support to the skin. The dermis contains blood vessels, nerves, hair follicles, sweat glands, and oil glands. It is also responsible for the production of collagen and elastin, which give the skin its strength and flexibility. The dermis can be further divided into two layers: the papillary dermis, which is the upper layer and contains finger-like projections called papillae that extend upwards into the epidermis, and the reticular dermis, which is the lower layer and contains thicker collagen bundles. Together, the epidermis and dermis make up the true skin.