Primary tuberculous glossitis in an immunocompetent patient.
(9/25)
Tuberculous glossitis is a rare entity that has been described sporadically. Primary tuberculous glossitis, as described in this case report, is still exceptional. A 25-year-old male with no known immunosuppressive disorder presented with a tuberculoma at the base of his tongue. This was confirmed by tongue biopsy and a positive polymerase chain reaction response to the mycobacterium. The patient had a favourable response to anti-tubercular treatment. This highlights the importance of considering tuberculosis in the differential diagnosis of chronic tongue lesions, even in the absence of pulmonary tuberculosis. (+info)
Glossitis and tongue trauma subsequent to administration of an oral medication, using an udder infusion cannula, in a horse.
(10/25)
A 10-year-old gelding was presented with a tongue that had swelled immediately after oral administration of oxfendazole, using an udder infusion cannula. The tongue appeared to have been punctured inadvertently. The horse recovered after treatment with intravenous fluid, antibiotics, and anti-inflammatory drugs. Administering oral medication by this method should be discouraged. (+info)
High JC virus load in tongue carcinomas may be a risk factor for tongue tumorigenesis.
(11/25)
Median rhomboid glossitis: secondary to colonisation of the tongue by Actinomyces (a case report).
(12/25)
Median rhomboid glossitis is an inflammatory lesion of the tongue, now believed to be secondary to candidiasis. We document a case of median rhomboid glossitis with heavy colonisation by Actinomyces in a 60-year-old male. We propose that Actinomyces, like Candida, induces pseudoepitheliomatous hyperplasia of the mucosa of the tongue and florid inflammatory hyperplasia of the underlying connective tissue, resulting in the characteristic elevated lesion. Actinomyces has not earlier been implicated as a cause of median rhomboid glossitis. (+info)
Helicobacter pylori coinfection is a confounder, modulating mucosal inflammation in oral submucous fibrosis.
(13/25)
Although easily examined, abnormalities of the tongue can present a diagnostic and therapeutic dilemma for physicians. Recognition and diagnosis require a thorough history, including onset and duration, antecedent symptoms, and tobacco and alcohol use. Examination of tongue morphology and a careful assessment for lymphadenopathy are also important. Geographic tongue, fissured tongue, and hairy tongue are the most common tongue problems and do not require treatment. Median rhomboid glossitis is usually associated with a candidal infection and responds to topical antifungals. Atrophic glossitis is often linked to an underlying nutritional deficiency of iron, folic acid, vitamin B12, riboflavin, or niacin and resolves with correction of the underlying condition. Oral hairy leukoplakia, which can be a marker for underlying immunodeficiency, is caused by the Epstein-Barr virus and is treated with oral antivirals. Tongue growths usually require biopsy to differentiate benign lesions (e.g., granular cell tumors, fibromas, lymphoepithelial cysts) from premalignant leukoplakia or squamous cell carcinoma. Burning mouth syndrome often involves the tongue and has responded to treatment with alpha-lipoic acid, clonazepam, and cognitive behavior therapy in controlled trials. Several trials have also confirmed the effectiveness of surgical division of tongue-tie (ankyloglossia), in the context of optimizing the success of breastfeeding compared with education alone. Tongue lesions of unclear etiology may require biopsy or referral to an oral and maxillofacial surgeon, head and neck surgeon, or a dentist experienced in oral pathology. (+info)
The development and inflammatory features of radiotherapy-induced glossitis in rats.
(16/25)
OBJECTIVES: To improve the existing animal models (mice, rats, and hamsters) for radiotherapy-induced oral mucositis (RTOM), thereby establishing a radiotherapy-induced glossitis (RTG) Sprague-Dawley (SD) rat model. STUDY DESIGN: A lead device was designed to limit radiation exposure to a 1x1 cm2 area of a rat 's dorsal anterior tongue with a single 30 Gy of X-ray radiation. The general conditions of the irradiated rats, such as body-weight and behavior, were observed. The oral mucositis index (OMI) of the RTG rats were measured daily. Histological changes of the irradiated tongue tissues were assayed by H &E staining. RESULTS AND CONCLUSION: No significant changes were clinically observed 3 to 4 days after irradiation. At 5 to 6 day, punctuation and confluenced redness of the mucosa were observed. The small blood vessels became more extensive, engorged, thin vessel walls. More infiltrating cells were observable, necrosis and exfoliation of the squamous cells appeared, and the formation of an ulcerative lesion could be observed. Seven to 15 days, the exfoliated epithelial layer was observed to have formed an ulcerative lesion, then aggravated ulcerative lesions consisting of pseudomembranous filament exudates could be observed. The structure of the epithelium had become completely disintegrated, forming deep, microscopic ulcerative lesions. Twenty-one days, the periphery of the ulcer was observed to have begun to heal, and granulation tissue could be observed at the bottom of the ulceration. At 35 days after irradiation, the epithelial structure presented again, but the epithelium was very thin. An RTG animal model was successfully established in SD rats, which provides a new research platform for the study of RTOM pathogenesis. (+info)