Teaching resources. Growth factor and receptor tyrosine kinases. (49/318)

This Teaching Resource provides lecture notes and slides for a graduate-level class on ligand regulation of signaling by receptor tyrosine kinases and receptors involved in the Wnt canonical pathway. It is part of a series of lectures that constitute the Cell Signaling Systems course. A description of the lecture, along with a set of slides used to present this information, is provided.  (+info)

Teaching resources. Protein kinases. (50/318)

This Teaching Resource provides lecture notes and slides for a class covering the structure and function of protein kinases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the genomics and evolutionary relationships among kinases and then proceeds to describe the structure-function relationships of specific kinases, the molecular mechanisms underlying substrate specificity, and selected issues in regulation of kinase activity.  (+info)

Teaching resources. Protein phosphatases. (51/318)

This Teaching Resource provides lecture notes and slides for a class covering the structure and function of protein phosphatases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the importance of phosphatases in physiology, recognized by the award of a Nobel Prize in 1992, and then proceeds to describe the two types of protein phosphatases: serine/threonine and tyrosine phosphatases. The information covered includes the structure, regulation, and substrate specificity of protein phosphatases, with an emphasis on their importance in disease and clinical settings.  (+info)

Teaching resources. Protein domains that interact with receptor tyrosine kinases: structural aspects. (52/318)

This Teaching Resource provides lecture notes and slides for a class covering insights gained from structural analysis of the regulation of receptor tyrosine kinases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with an overview of the many protein domains thus far implicated in cell signaling and then describes in detail the phosphotyrosine-binding domain (PTB). The application of structural information to rational drug design by targeting protein interaction domains is also covered.  (+info)

Effectiveness of using cross-sections in the recognition of anatomical structures in radiological images. (53/318)

This study measured the effect of using anatomical cross-sections to enhance the interpretation of radiological images. It examined the effectiveness of using magnetic resonance (MR or MRI) images presented side-by-side with their corresponding cross-sectional images, as compared to using only the MR images. Student aptitude to identify anatomical structures in the radiological images was measured. The study also assessed student preferences toward the two presentation formats. Thirty-four freshmen medical students (17 females and 17 males) and a female graduate student enrolled in a clinical anatomy, embryology, and imaging course volunteered to participate in the study. A posttest-only control group design was used and the collected data were analyzed by a t-test. A survey was developed to collect student perceptions of the two presentation formats. There was no significant difference between using MR images with cross-section images and using MR images alone in the students' immediate recall of anatomical information presented in radiological images. However, the students showed strong preferences for the presentation of MR images with cross-section images and indicated that it would help them interpret radiological information.  (+info)

Desperately seeking diversity. (54/318)

It is worthwhile to consider the basis for success in achieving diversity in MD programs and the failure to do so in PhD programs and to ask what can be done to remedy the situation. One reason medical schools have been more successful in achieving diversity than PhD programs is that more attention has been paid to the need for diversity.  (+info)

Teaching resources. Structure of G-protein-coupled receptors and G proteins. (55/318)

This Teaching Resource provides lecture notes and slides for a class covering the structure and function of G protein-coupled receptors and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the crystal structure of rhodopsin and G protein subunits and then proceeds to describe the molecular mechanisms of receptor activation and the subsequent release of G proteins.  (+info)

Teaching resources. G-protein-coupled receptors. (56/318)

This Teaching Resource provides lecture notes and slides for a class covering G protein-coupled receptors (GPCRs) and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the major classes of GPCRs and then proceeds to describe the mechanisms of receptor diversity, ligand interaction, desensitization, coupling, and mutations associated with human diseases.  (+info)