Effects of a dietary antimicrobial (carbadox) on liver cholesterol 7 alpha-hydroxylase activity and bile acid patterns in the young pig.
(25/38)
Two experiments were conducted to investigate the effects of the antimicrobial carbadox (CX) on bile acid metabolism in the young pig. The pigs were fed a fortified, 19.5% crude protein, corn-soybean meal diet without or with 55 ppm CX. In Exp. I pigs were fed the diets for 28 d, then the level of activity of hepatic cholesterol 7 alpha-hydroxylase (CH-7 alpha), the rate-limiting enzyme of bile acid metabolism, was measured. The CX-fed pigs gained faster (P less than .05) and more efficiently (P less than .05) and had lower (P less than .02) CH-7 alpha activity than the control pigs. In Exp. II, pigs ranging in weight from 12 to 15 kg were fitted with indwelling catheters in the hepatic portal (HP) and anterior vena cava (VC) veins. Radiolabeled chenodeoxycholic acid (CDC) was infused into the HP and blood samples from both veins were taken at meal time and hourly for 6 h following six meals over 3 d. Bile was collected 14 d after infusion. Concentrations of lithocholic acid (LC) in the bile and hyodeoxycholic acid (HDC) in the plasma were reduced by dietary CX. Dietary CX did not significantly affect metabolism of plasma CDC or hyocholic acid (HC) as measured by radioactivity. Meal time (0800 vs 1600) affected (P less than .05) plasma CDC radioactivity at all times and the level of HDC radioactivity 2 h post-prandial. There was a meal time X dietary treatment interaction (P less than .02) on plasma HC radioactivity 2 h post-prandial. These data suggest that dietary CX inhibited intestinal microbial degradation of CDC and HC. (+info)
Hygromycin A, an antitreponemal substance. II. Therapeutic effect for swine dysentery.
(26/38)
This study was conducted to evaluate hygromycin A fed to growing swine at 1, 5, 10 or 20 g/ton feed for the control of Treponema hyodysenteriae-caused dysentery. Pigs provided carbadox at 50 g/ton feed served as an infected treatment control group. All pigs were orally, via stomach intubation, administered 100 ml of a T. hyodysenteriae broth culture. During the in vivo test, rectal swabs were taken for T. hyodysenteriae isolation, body weights of all pigs and the feed consumption was determined. All pigs were euthanized and necropsied at study end; the large intestine was cultured for T. hyodysenteriae and gross intestinal lesions were noted. T. hyodysenteriae-caused swine dysentery was successfully controlled by feeding hygromycin A at 5 g/ton. Hygromycin A medicated pigs performed as well as or better than carbadox-medicated pigs. (+info)
The effects of a dietary antimicrobial on the biological half-life of chenodeoxycholic acid and plasma bile acid concentration patterns in the young pig.
(27/38)
Carbodox (CX), an antimicrobial agent, was fed at 0 or 58 ppm in a 19.5% crude protein corn-soybean metal diet to young pigs (12 to 15 kg). Radiolabeled chenodeoxycholic acid (CDC) was infused into the hepatic portal vein; after each of the subsequent six meals, blood samples were collected from the anterior vena cava (VC) and the hepatic portal (HP) veins. For the first 5 min after CDC infusion, the level of radioactivity in the CX pigs was significantly lower in the HP plasma and the slopes of the two curves of the plasma activity for the first hours were significantly different. The plasma bile acid concentrations (as measured by radioactivity) were significantly higher in the CX-treated animals following all meals. The biological half-life of CDC was 6.4 d in the controls and 5.7 d in the CX pigs. The increased rate of excretion was significant. These data indicate that bile acid metabolism in the young pig was significantly affected by feeding a subtherapeutic level of the antimicrobial CX. (+info)
Probable elimination of swine dysentery after feeding ronidazole, carbadox or lincomycin and verification by feeding sodium arsanilate.
(28/38)
Swine dysentery did not recur during a nine week period after withdrawal of medication in swine fed ronidazole at a level of 60 parts per million of feed for ten weeks or fed either carbadox at 55 ppm or lincomycin at 110 ppm of feed for six weeks. During this period swine dysentery was neither transmitted to accompanying sentinels after the withdrawal of the above medication or was Treponema hyodysenteriae isolated and cultured or observed in stained smears from rectal swabs and feces or from colonic scrapings at necropsy. Beginning three weeks after the withdrawal of medication, all swine were fed sodium arsanilate at a concentration of 220 ppm of feed for three weeks in an attempt to excite the carrier of swine dysentery into developing a swine dysentery diarrhea. A swine dysentery diarrhea did recur during the feeding of sodium arsanilate in swine previously fed ronidazole at a level of 60 ppm of feed for only six weeks. It was concluded: that swine dysentery was probably eliminated with the feeding of ronidazole for the longer duration and with the feeding of carbadox and lincomycin and that sodium arsanilate was of value in identifying the carrier state. (+info)
Effect of carbadox on growth, fasting metabolism, thyroid function and gastrointestinal tract in young pigs.
(29/38)
Five experiments were done with 34 weanling and 24 growing crossbred gilts. Individually penned pigs were fed ad libitum (expt 1) or pair-fed (expt 2 through expt 5) for either 2 (expt 1 through expt 4) or 3 (expt 5) wk. Mean body weight gain and gain/feed values were significantly (P less than 0.05) greater in pigs fed carbadox (a synthetic antimicrobial). Fasting O2 consumption and CO2 production of pigs were measured during the 32- to 48-h (expt 1, 4 and 5) or during the 24- to 40-h (expt 2 and 3) postprandial periods with indirect open circuit calorimeters. Carbadox reduced O2 consumption significantly (P less than 0.05) in expt 2, but had no significant effect on CO2 production in any of the five experiments. The weight of thyroid gland and the plasma concentrations of L-3,3',5-triiodothyronine (T3) and thyroxine (T4) of pigs were not altered by carbadox. The mean weight, but not the length, of small intestine tended to be less in pigs fed carbadox. It is suggested that the growth-promoting effect of carbadox on young pigs may be associated with the weight of small intestine and its physiological processes such as metabolic rate. However, no definite effects of carbadox on whole-animal fasting metabolic rate and thyroid function could be demonstrated by the methods used in the present study. (+info)
Efficacy of tiamulin as a growth promotant for growing swine.
(30/38)
A study involving 244 pigs initially averaging 13 kg was conducted at two stations to evaluate tiamulin as a growth promotant for growing swine. In each experiment, four replicate pens of five (Exp. 1) or six (Exp. 2) pigs/pen were used to evaluate each treatment. In Exp. 1, pigs were fed 0, 11, 22 or 44 ppm tiamulin from 15 to 58 kg, then fed a nonmedicated control diet for the remainder of the experiment (to 95 kg). In Exp. 2, pigs were fed 0, 2.75, 5.5, 11 or 22 ppm tiamulin from 11 to 56 kg, followed by the nonmedicated control diet (to 95 kg). In each experiment, carbadox (55 ppm) was included as a positive control and was fed to an average weight of 35 kg, followed by the control diet. Averaged across all dietary levels, tiamulin resulted in a 14.1% improvement in gain and a 5.7% improvement in feed:gain ratio during the first 28 to 35 d of the experiment (to 30 kg). These improvements were slightly less than those resulting from the feeding of carbadox during the same period (21.5 and 6.9%, respectively). From 13 to 57 kg, pigs fed tiamulin gained 11.6% faster and 3.1% more efficiently than did controls. Over the entire experiment (13 to 95 kg), tiamulin-fed pigs gained 5.7% faster than did controls, even though the tiamulin was withdrawn at 57 kg body weight. Growth rate from 13 to 57 kg plateaued at the 11-ppm dietary level of tiamulin; whereas, feed:gain ratio plateaued at the 22-ppm level. The results indicate that tiamulin is an effective growth promotant for growing swine. (+info)
Responses of weanling pigs to dietary supplementation with vitamin C or carbadox.
(31/38)
A 2 X 2 factorial arrangement with two levels (0, 660 ppm) of vitamin C and two levels (0, 55 ppm) of carbadox supplementation was used in two experiments with 112 crossbred pigs weaned between 4 and 5 wk of age. An 18% protein corn-soybean meal-oats-dried whey starter diet was used as the basal diet. Each diet was fed ad libitum for a 4-wk period to three replicates of four pigs in Exp. 1 and to four replicates of four pigs in Exp. 2. Vitamin C supplementation produced a significantly higher plasma vitamin C concentration in weanling pigs, but, contrary to results of our previous study, failed to improve average daily gain of the pigs. Daily gain was, however, improved significantly by carbadox supplementation. Carbadox also produced a significantly higher plasma vitamin C concentration in pigs after a 7-d lag period. Plasma Fe concentration of pigs was not affected by supplemental vitamin C, but was significantly higher in those fed carbadox-supplemented diets. Plasma ceruloplasmin concentration increased significantly in all treatment groups from the initial sampling period (d 0) to subsequent periods. No interactions between supplemental vitamin C and carbadox were observed in daily gain, feed efficiency and the measured plasma constituents. (+info)
Effect of lysine, tryptophan and(or) carbadox additions to low protein corn-soybean meal diets for young pigs.
(32/38)
Addition of L-lysine (Lys), L-tryptophan (Trp) and(or 55 ppm carbadox (C) to low protein corn-soybean meal diets was evaluated in two experiments using 444 crossbred pigs. In Exp. 1, initial and final weights of pigs were 17.7 and 33.3 kg, respectively, for the 28 d experiment. Pigs fed the 13% protein diet containing added Lys (.17%) or Lys + C had average daily gains (ADG) similar to those fed the 16% protein diet (positive control group) and greater (P less than .05) than those of pigs fed the 13% protein diet (negative controls). Pigs fed the 13% protein diets containing C had average daily feed intakes (ADFI) and ADG similar to those of pigs fed the 13% protein diet / Lys. Main effect comparisons among the 13% protein groups indicated that C increased (P less than .05) ADFI and ADG and that Lys increased (P less than .01) ADG and G:F ratio. In Exp. 2, the initial pig weight for the 28 d starter period averaged 7.4 kg. A 28 d grower period followed, in which the protein level was lowered 2% across treatments. The high and low dietary protein level sequences consisted of 18 and 15%, respectively, during the starter period followed by 16 and 13%, respectively, during the grower period. Lys and(or) Trp additions were also lowered from .18 and .05% to .15 and .04%, respectively. The overall 56 d performance indicated that pigs fed the low protein dietary sequence supplemented with either Lys or C had ADFI and ADG similar to those of the high protein dietary sequence positive control group and greater (P less than .05) than those of the low protein negative control group. The combination of Lys + C further increased (P less than .05) the ADG over that of the high protein sequence group. Overall main effect comparisons among the low protein dietary sequence groups indicated that either added Lys or C increased (P less than .01) ADFI and ADG, with added Lys also increasing G:F ratio. However, added Trp did not improve any performance characteristics. These results indicate that C had a Lys sparing effect in low protein corn-soybean meal diets fed to young pigs. (+info)