Cell Physiological Processes

Processi Fisiologici

Pathological2

• Estrogen regulates a plethora of biological processes, under physiological and pathological conditions, by affecting key pathways involved in the regulation of cell proliferation, fate, survival and metabolism. (unife.it)
• As a matter of fact, as is well known, in any physiological and/or pathological condition a subject could be involved, 'oxidative stress' results from the imbalance between Reactive Oxygen Species (ROS) production and his antioxidant capacity. (unimi.it)

Biological1

• This initial approach performed with young cells paves the ways for future studies with hDPSCs derived from old subjects, in order to develop a bioactive material customised for an ageing population In conclusion, our results confirmed that ageing differently impaired hDPSCs biological properties and local factors may modulate these processes. (univpm.it)

Organs2

• Ageing is a physiologic phenomenon occurring with time, which hamper the organs' functional capacity that normally maintains tissue homeostasis and physiological responses. (univpm.it)
• Appropriate knowledge on the structure of the animal cell and on the organization of animal tissues and organs are required. (unito.it)

Known2

• Electron Paramagnetic Technique (EPR) resulted the method of choice since, as is well known, it is the only technique capable of returning, in a non-invasive way, the 'intrinsic' quantitative information (the signal is proportional to the number of excited electron spins). (unimi.it)
• Moreover, it is well known that aged cells significantly affect their microenvironment, as they secrete pro-inflammatory and matrix-degrading molecules. (univpm.it)

Development2

• The Notch receptors are medikors of communication between adjacent cells and are key determinants of cell fate during development and in postnatal life. (unife.it)
• Crosstalk between estrogen and the Notch pathway intervenes in many processes underlying the development and maintenance of the cardiovascular system. (unife.it)

Affect1

• However a fully innovative method had been developed, so that we lacked of referring literature data: a series of preliminary measurements on a homogeneous group of healthy subjects had to be firstly carried out, not only to optimize the acquisition and environmental conditions (T, pO2 that have to be carefully defined since they greatly affect EPR data), but also to reach reliable resting physiological values and range of variability. (unimi.it)

Phenotype2

• Although numerous evidences have emerged over the last 60 years on the potential possibility of inducing a reversion of the malignant phenotype of cancer cells, such a hypothesis has never been systematically explored by the international scientific community. (unicampus.it)
• These innovative therapeutic strategies aim at modifying the morphogenetic fields that guide the processes of cellular differentiation and organization and which, on tumor cells, can induce a transition of the state of the tumor phenotype from malignant to benign. (unicampus.it)

Biology2

• Research on Stem Cell and Macrophage Biology. (reginahuebner.net)
• We have come a long way you and I. I came from a pure cell biology background and you permitted me to draw a bridge between basic and biomedical research. (reginahuebner.net)

Infection4

• Platelets are classically recognized for their important role in hemostasis and thrombosis but they are also involved in many other physiological and pathophysiological processes, including infection. (cardiologicomonzino.it)
• Platelets are among the first cells recruited to sites of inflammation and infection and they exert their antimicrobial response actively cooperating with the immune system. (cardiologicomonzino.it)
• Research on B-Cell Immunology to Infection. (reginahuebner.net)
• On the other hand, during an infection, the sense of self is heightened because it results in a war between the organism: in this case the human being, i.e. me and you, the pathogen. (reginahuebner.net)

Expression1

• In this perspective, tumor reversion processes can be interpreted as processes that intervene on the dynamic relationship between gene and microenvironment, modifying the phenotypic expression of tumor cells. (unicampus.it)