• The inhibitory effect of STI-571 suggests a role for c-kit tyrosine kinase on glucose transport activation not only by SCF, but also by H2O2. (unimore.it)
  • On the other hand, neither protein kinase C nor phosphoinositide-3-kinase appear to be involved in the acute activation of glucose transport. (unimore.it)
  • Results revealed a complex transcriptomic response to cold with many molecular pathways involved among which: lipid and carbohydrate metabolism, regulation of heat shock proteins (HSPs) and other protein chaperones, protein degradation and repair, regulation of cell death, RNA and DNA metabolism, immune response. (diazilla.com)
  • ii) both stimuli could share at least some signaling pathways leading to glucose uptake activation, involving protein tyrosine kinases and PLC iii) H2O2 could act increasing the level of tyrosine phosphorylation through the inhibition of tyrosine phosphatases and mimicking the regulation role of endogenous ROS. (unimore.it)
  • It is worth noting that the patients that are negative for PTPRG expression at diagnosis re-express it when the therapeutic treatement is successful. (univr.it)
  • Overall we aim at the elucidation of the molecular mechanisms underlying the oncosuppressive effect in CML blasts and to the development of new molecular assays (both at the mRNA and protein level) for the evaluation of PTPRG expression in clinical samples. (univr.it)
  • Strategies aimed to the activation of PTPRG expression/enzymatic activity in CML blast are also planned in order to evaluate the therapeutic potential of the reactivation of this phosphatase. (univr.it)