Alteration of rat hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities by Satureja khuzestanica Jamzad essential oil. (1/14)

PURPOSE: Regarding reported antidiabetic effect of Satureja khuzestanica essential oil (SKEO) and important role of liver on body glucose metabolism by glycogenolysis and gluconeogenesis, we were interested to examine effect of SKEO treatment on rat hepatic key enzymes of glycogenolysis and gluconeogenesis in vivo. METHODS: Effective antidiabetic dose of SKEO (1000 ppm) was administered to rats through drinking water for 2 weeks. After 18 hours fasting post treatment under general anesthesia, the liver was removed by transverse abdominal incision and perfused with cold 0.9% saline and kept frozen at -70 degrees C until homogenized. The activities of the key enzymes glycogen phosphorylase (GP) and phosphoenolpyruvate carboxykinase (PEPKC) were analyzed in the homogenate. Blood sample was taken by cardiac puncture for glucose assay. RESULTS: SKEO treatment did not affect blood glucose concentrations but decreased hepatic PEPCK activity by 26% (P<0.01) of control and increased hepatic GP by 24% (P<0.01) of control. CONCLUSION: Disturbance of hepatic glucose metabolism is proposed as a mechanism of antidiabetic action of SKEO which could be in relation with antioxidant property of this plant.  (+info)

An anti-inflammatory and anti-nociceptive effects of hydroalcoholic extract of Satureja khuzistanica Jamzad extract. (2/14)

PURPOSE: Satureja khuzistanica Jamzad (Lamiaceae) is an endemic plant that widely distributed in the southern parts of Iran. This plant has been used as analgesic and antiseptic among the inhabitants of southern parts of Iran. METHODS: The Satureja khuzistanica hydroalcoholic extract was prepared and its anti-inflammatory and anti-nociceptive effects were investigated using the carrageenan-induced rat paw edema and formalin test. RESULTS: A similar anti-inflammatory activity was seen between S. khuzistanica hydroalcoholic extract (150 mg/kg; i.p.) and indomethacin (4 mg/kg; i.p.) in carrageenan test. The extract showed anti-nociceptive activity in a dose-dependent (10-150 mg/kg; i.p.) manner at the second phase of formalin test which was comparable with morphine (3 mg/kg; i.p.). CONCLUSION: This study confirms that anti-inflammatory and anti-nociceptive properties of S. khuzistanica are comparable to those of indomethacin and morphine. Presence of flavonoids, steroids, essential oil, mainly carvacrol and tannin might be responsible for anti-inflammatory and anti-nociceptive activities of this plant.  (+info)

Essential oils of Satureja species: insecticidal effect on Culex pipiens larvae (Diptera: Culicidae). (3/14)

The chemical composition of the essential oils of the wild growing plants of Greek S. spinosa L., S. parnassica subsp. parnassica Heldr.& Sart ex Boiss., S. thymbra and S. montana were determined by GC and GC/MS analysis. The larvicidal activities of the essential oils were assayed against Culex pipiens biotype molestus. The analytical data indicated that various monoterpene hydrocarbons and phenolic monoterpenes constitute the major constituents of the oils, but their concentration varied greatly among the oils examined. The bioassay results indicated that the oils possess significant larvicidal activities and represent an inexpensive source of natural substances mixture that exhibit potentials for use to control the mosquito larvae.  (+info)

Essential oil composition and internal transcribed spacer (ITS) sequence variability of four South-Croatian Satureja species (Lamiaceae). (4/14)

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Insecticidal activity of the essential oils from different plants against three stored-product insects. (5/14)

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Antimicrobial activity of Satureja montana L. essential oil against Clostridium perfringens type A inoculated in mortadella-type sausages formulated with different levels of sodium nitrite. (6/14)

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Scolicidal effects of Olea europaea and Satureja khuzestanica extracts on protoscolices of hydatid cysts. (7/14)

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Antimicrobial and antioxidant activities of essential oils of Satureja thymbra growing wild in Libya. (8/14)

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