Serum pepsinogen and gastric cancer screening.
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Since the 1990's, the test for serum pepsinogen as a marker for chronic atrophic gastritis has been incorporated into gastric cancer screening programs, on a trial basis, to identify people at high risk for gastric cancer. The addition of the serum test to the cancer screening program has been shown to improve the detection rate of cancer and pepsinogen testing is useful in detecting early-stage gastric cancers arising from atrophic gastric mucosa, which macroscopically tend to be elevated and histologically differentiated. Furthermore, the cost for the detection of a single cancer case is much less than that for conventional screening. Thus, with the introduction of pepsinogen testing, complimenting barium X-ray, a more efficient screening system is available. (+info)
[(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor.
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Room-temperature semiconductor detectors for in vivo monitoring of internal contamination.
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In vivo monitoring of low-energy X-ray and gamma-ray emitters has always been a difficult task, primarily because of lack of accuracy and the high detection limits of classical techniques. Various types of PIN diodes (diodes with a large intrinsic zone) were tested in the Radiation Protection Department of the Studie Centrum voor Kernenergie, Centre d'etude de l'Energie Nucleaire (Mol, Belgium) in the measurement of radioactive body burden by direct methods. Current research is oriented toward the use of room-temperature diodes for the detection of low-energy photons escaping the body. In this paper, a new counting technique that involves a portable jacket containing the diodes is described. The system uses silicon diodes and is used out of shielding room in order to be near the contamination. With this method rapid analysis and long counting times are possible, stress is reduced, and medical treatment can be optimized. CdZnTe detectors were also evaluated for this measurement technique but this type of detector is better adapted for counting inside a shielding room. The improvement of the accuracy of the measurement, taking into account the effect of the ribs, is described here, as well the associated electronics necessary for this type of counting. (+info)