Historical cohort study of a New Zealand foundry and heavy engineering plant. (1/198)

OBJECTIVES: To investigate the mortality of workers who had been exposed to asbestos, machining fluids and foundry work in a foundry and heavy engineering plant in the railway rolling stock manufacturing industry in New Zealand. METHODS: Historical cohort study design. RESULTS: For the total workforce of 3522 men employed between 1945 and 1991, follow up was 90% of person-years to 31 December 1991. Significantly increased standardised mortality ratios (SMRs) were found for all causes of death combined (SMR 1.07; 95% confidence interval (95% CI) 1.01 to 1.14), all malignancies (SMR 1.15; 95% CI 1.01 to 1.31), circulatory (SMR 1.16; 95% CI 1.07 to 1.27) and musculoskeletal diseases (SMR 3.06; 95% CI 1.39 to 5.84), all digestive cancers (SMR 1.29; 95% CI 1.04 to 1.59), all respiratory cancers (SMR 1.34; 95% CI 1.08 to 1.65), cancer of the oesophagus (SMR 1.97; 95% CI 1.01 to 3.45), and mesothelioma of the pleura (SMR 6.58; 95% CI 1.24 to 19.49). Three deaths from pleural mesothelioma were recorded, with latency times of 51, 53, and 57 years. There were no dose-response relations between exposure to asbestos, machining fluids or foundry work, or by duration of employment in the plant, and any cause of death. CONCLUSIONS: This study found small increases in risk for several causes of death among foundry and heavy engineering workers; however, these increases were small and the possible effects of smoking and other lifestyle factors could not be excluded. There was evidence of asbestos related disease in those involved in engineering work in the past.  (+info)

Engine reconditioning workshops: lead contamination and the potential risk for workers: a pilot study. (2/198)

Lead concentrations were measured in surface dust, airborne dust, air, and grinding material from five engine reconditioning workshops to evaluate the impact on blood lead concentrations (PbB) of 10 employees. Lead in the environmental samples ranged from trace amounts to extremely high concentrations (4667 mg/m2). The highest concentrations in surface wipes were found in areas where engine deposits are removed from valves and valve seats. The amounts of lead in long term dustfall accumulation and static air filter samples varied with the position in the workshop and the amount of ventilation. In all but one workshop, the air lead concentrations exceeded Australian occupational guidelines of 150 micrograms Pb/m3. PbB ranged from 4.5 to 25.3 micrograms/dl. There was an empirical relation between the cleanliness, work practices, ventilation of the workshops, lead concentrations in environmental samples and PbB. Office employees not directly exposed to the leaded dust had the lowest PbB. Those who smoked had the highest PbB. Several relatively inexpensive recommendations were made to the owners to minimise exposure of the workers and in most cases these have been implemented.  (+info)

Closer to a compromise on the direction of environmental research. (3/198)

The Committee for the National Institute for the Environment (CNIE) was created in 1990 "to improve the scientific basis for making decisions on environmental issues," possibly through the establishment of a separate institute devoted to the environmental sciences. But while the goals proposed for the National Institute for the Environment were universally applauded, Congress was averse to adding a new agency to the federal bureaucracy. Recently, a compromise plan has been proposed that could expand the science base without having to create a new agency. On 29 July 1999, the National Science Board approved an interim report recommending an expanded program of environmental research and research planning, education, and scientific assessment with a funding target of an additional $1 billion over five years. The report stresses the importance of environmental research in formulating environmental protection programs and contains 12 recommendations intended to enhance and complement existing research activities in environmental sciences and engineering. If the National Science Foundation implements the recommendations in the report and if Congress appropriates funds for that purpose, the need for additional funding for new science activities identified by the CNIE should be satisfied.  (+info)

DNA computing the Hamiltonian path problem. (4/198)

The directed Hamiltonian path (DHP) problem is one of the hard computational problems for which there is no practical algorithm on a conventional computer available. Many problems, including the traveling sales person problem and the longest path problem, can be translated into the DHP problem, which implies that an algorithm for DHP can also solve all the translated problems. To study the robustness of the laboratory protocol of the pioneering DNA computing for the DHP problem performed by Leonard Adleman (1994), we investigated how the graph size, multiplicity of the Hamiltonian paths, and the size of oligonucleotides that encode the vertices would affect the laboratory procedures. We applied Adleman's protocol with 18-mer oligonucleotide per node to a graph with 8 vertices and 14 edges containing two Hamiltonian paths (Adleman used 20-mer oligonucleotides for a graph with 7 nodes, 14 edges and one Hamiltonian path). We found that depending on the graph characteristics such as the number of short cycles, the oligonucleotide size, and the hybridization conditions that used to encode the graph, the protocol should be executed with different parameters from Adleman's.  (+info)

Surveillance of occupational and work-related diseases between 1993 and 1996 in an engineering company. (5/198)

There are established reporting schemes for some occupational and work-related illnesses but these schemes may underestimate the true incidence of such diseases. Not all cases may be referred to a participating physician and access to adequate diagnostic facilities are not always available. Collecting data directly from occupational health departments may overcome some problems related to under-reporting as they have good access to the entire working population within their company. The aim of this paper is to report the results from such a reporting scheme operated by a large multi-national engineering company during the period 1993-96. All UK sites of Lucas Industries (later LucasVarity) participated. A report form was completed by the occupational health department of each participating site each month. The report form gave abbreviated details of each case of occupational and work-related disease occurring at that site during the previous month. Forms were posted to a central office where the data was collated and analyzed. The incidence of respiratory diseases was broadly similar or slightly higher to that reported from other schemes. Musculoskeletal diseases were by far the most common category of disease reported. During a four year period of reporting the incidence of occupational and work-related diseases decreased overall by approximately 75%. As the reported incidence of respiratory disease was comparable with or slightly higher than that from other schemes, it appears that reporting schemes such as this can provide useful and accurate data. Musculoskeletal diseases are the most common type of disease attributed to work and should probably receive greater attention. The decrease in incidence seen in LucasVarity over time may reflect increased emphasis given to health and safety issues within the company during the reporting period.  (+info)

Do health checks cause stress? (6/198)

Data are reported concerning social responses to health checks in an occupational setting. Previous research has suggested that screening may be a stressful experience. This, in turn, has contributed to a degree of scepticism about the value of health checking. No evidence was found in the present study to support the proposition that health checks cause such responses. It is shown that health checks prompt recipients to try to engage in health promoting behavioural changes. The study was a randomized controlled trial of 1,371 persons employed in a large engineering factory in the West of Scotland.  (+info)

Two cases of thyroid cancer in a small workforce. (7/198)

In 1994, in a large parcel depot in the north of England employing 600 staff and 24 electrical and mechanical engineers, two engineers developed papillary cell carcinoma of the thyroid in the same year. A comprehensive review of the literature revealed that ionizing radiation is the only known direct cause of this disease. There was speculation that air filter changing undertaken by the two men affected, shortly after the Chernobyl accident in 1986, may have exposed them to concentrated radioactive fallout. A radiation survey of the parcel depot was undertaken and revealed no evidence of abnormal radioactivity. A total of 27 past and present engineering staff were screened for thyroid cancer. No cases of thyroid cancer were found. Investigation of clusters of rare disease in the occupational setting is indicated mainly in order to address the concerns of the workforce. Nevertheless, investigation is warranted, especially when the aetiology of a disease is poorly understood. It would be prudent for doctors, in whatever speciality, to take an occupational history from individuals who develop thyroid cancer.  (+info)

Increased risk of obstructive pulmonary disease in tunnel workers. (8/198)

BACKGROUND: Tunnel workers are exposed to gases and particles from blasting and diesel exhausts. The aim of this study was to assess the occurrence of respiratory symptoms and airflow limitation in tunnel workers and to relate these findings to years of exposure. METHODS: Two hundred and twelve tunnel workers and a reference group of 205 other heavy construction workers participated in a cross sectional investigation. Exposure measurements were carried out to demonstrate the difference in exposure between the two occupational groups. Spirometric tests and a questionnaire on respiratory symptoms and smoking habits were applied. Atopy was determined by a multiple radioallergosorbent test (RAST). Radiological signs of silicosis were evaluated. Respiratory symptoms and lung function were studied in relation to years of exposure and adjusted for smoking habits and atopy. RESULTS: Compared with the reference subjects the tunnel workers had a significant decrease in forced vital capacity (FVC) % predicted and forced expiratory volume in one second (FEV(1)) % predicted when related to years of exposure. Adjusted FEV(1) decreased by 17 ml for each year of tunnel work exposure compared with 0.5 ml in outdoor heavy construction workers. The tunnel workers also reported significantly higher occurrence of respiratory symptoms. The prevalence of chronic obstructive pulmonary disease (COPD) was 14% in the tunnel workers compared with 8% in the reference subjects. CONCLUSION: Exposure to dust and gases from diesel exhaust, blasting, drilling and rock transport in tunnel work enhances the risk for accelerated decline in FEV(1), respiratory symptoms, and COPD in tunnel workers compared with other heavy construction workers.  (+info)