Ubiquitin-activating enzyme: Mechanism and role in protein-ubiquitin conjugation. J Biol Chem 1982 Mar 10;257(5):2543-8. PMID ... In the first step, a ubiquitin-activating enzyme (known as E1) hydrolyzes ATP and adenylates a ubiquitin molecule. This is then ... This adenylated ubiquitin is then transferred to a cysteine of a second enzyme, ubiquitin-conjugating enzyme (E2). Lastly, a ... The most well-known example of a ubiquitin-independent proteasome substrate is the enzyme ornithine decarboxylase. Ubiquitin- ...
Ubiquitin is phosphorylated by PINK1 to activate parkin, Nature, 2014;510:162-166. ↑ Fallon L1, Bélanger CM, Corera AT et al. A ... La parkine est une enzyme de type ubiquitine ligase dont le gène, PARK2, est situé sur le chromosome 6 humain. Comme ubiquitine ...