Méthodes d'investigation des interactions protéine-protéine
... single vector system for high throughput screening and verification of protein interactions in living cells. », Nature ... La PLA (Proximity ligation assay) in situ est une méthode immunohistochimique utilisant des sondes pour la détection des ... Fang, Y. Trends in Biopharmaceutical Industry, 2007, 3, 34-38 (en) Higher-throughput, label-free, real-time molecular ... 16, no 2, 2006, p. 194-200 (PMID 16488145, DOI 10.1016/j.sbi.2006.02.002) (en) Gray JJ, « High-resolution protein-protein ...
Cellules souches cancéreuses
Identification of selective inhibitors of cancer stem cells by high-throughput screening », Cell, vol. 138, no 4, août 2009, p ... a critical review of sphere-formation as an assay for stem cells », Cell Stem Cell, vol. 8, no 5, mai 2011, p. 486-98 (PMID ... high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma », Cancer Cell, vol. 18, no 6, décembre 2010, p. 655- ... of cells with high drug efflux capacity in human tumor cells », Proceedings of the National Academy of Sciences of the United ...
Gène essentiel
Identification of 113 conserved essential genes using a high‐throughput gene disruption system in Streptococcus pneumoniae », ... Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants », Genome Research, vol. 19, no 12, 1er ... Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes », Nature Biotechnology, vol. 34, no 6, juin 2016, p ... High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism », PLOS ...