- Brain plasticity allows the central nervous system of a given organism to cope with environmental demands. (inserm.fr)
- These last years, accumulating evidence has indicated that microglia participate in normal and pathological development of the central nervous system and the establishment of axonal projections in the forebrain. (theses.fr)
- This study focused on heparan sulfate (HS) oligosaccharides, as potential biomarkers of MPS featured by neurological manifestations (MPS I, IIIB and IIIC), and possibly responsible of lesions in the central nervous system. (theses.fr)
- Substantial evidence also exists to support the production of cytokines within the mammalian central nervous system (CNS) that may function to regulate specific neuroinflammatory processes and physiological responses during cerebral trauma and autoimmune diseases. (inserm.fr)
- MS is an unpredictable, often debilitating disease of the central nervous system (CNS) that attacks the protective covering, or myelin, of the brain and spinal cord, causing inflammation and damage. (newswire.ca)
- In addition, since the development of the central nervous system. (paris-neuroscience.fr)
- Microglia, the resident macrophages of the brain, colonize the brain during early embryogenesis and regulate homeostasis in physiological conditions as well as in response to environmental insults, through phagocytosis and chemokine signaling. (theses.fr)
- In addition to a wide range of biological functions during both immune and inflammatory processes, cytokines have the ability to act on the brain to elicit neuroendocrine, metabolic, and behavioral changes in order to support host defense and tissue repair. (inserm.fr)
- Accumulating evidence renders the dogma obsolete according to which the structural organization of the brain would remain essentially stable in adulthood, changing only in response to a need for compensatory processes during increasing age and degeneration. (biologie-journal.org)
- This is currently known for astrocytes, the major glial cells in brain which are well-recognized as dynamic partners in the mechanisms of synaptic transmission, and for the tanycytes and pituicytes which contribute to the regulation of neurosecretory processes in neurohemal regions of the hypothalamus. (biologie-journal.org)
- Following pioneering works on the morphological reorganizations taking place in the hypothalamo-neurohypophyseal system under certain physiological conditions such as dehydration and lactation, studies on the gonadotropic system that orchestrates reproductive functions have re-emphasized the dynamic interplay between neurons and glia in brain structural plasticity processes. (biologie-journal.org)
- In this review, we present recent in vivo and in vitro studies that highlight the contribution of the MMP/TIMP system to various diseases of the nervous system, involving blood brain barrier breakdown, neuroinflammation, glial reactivity, neuronal death, reactive plasticity, and to developmental and physiological processes including cell migration, axonal sprouting and neuronal plasticity. (biologie-journal.org)
- Our main research topic is the physiological analysis of both subcortical and cortical brain structures involved in the control of normal and abnormal movements. (paris-neuroscience.fr)
- We study the brain systems of emotion. (paris-neuroscience.fr)
- The emerging idea is that the MMP/TIMP system also plays a major role in the pathology and physiology of the nervous system and that mastering MMP activity will set the basis for new and more efficient therapeutic strategies against nervous system disorders. (inserm.fr)
- In the last years, data has accumulated indicating that the MMP/TIMP system is expressed in the nervous system where it regulates neuro-immune interactions and plays a major role in pathophysiological processes. (biologie-journal.org)
- However, the breakdown of the protease-inhibitor balance may lead to the loss of tissue homeostasis and the development of degenerative and tumorigenic processes in various tissues. (inserm.fr)
- The MMP/TIMP system is involved in the development and function of cells of the immune system by promoting their differentiation, activation, migration across basement membranes and tissues. (biologie-journal.org)
- In all, a further understanding of the role of MMPs and TIMPs in the nervous system should contribute to unravel mechanisms of neuronal plasticity and pathology and set the basis of new therapeutic strategies in nervous system disorders based on the development of synthetic MMP inhibitors. (biologie-journal.org)
- Our groundbreaking therapeutic kits are a combination of Advanced Nutraceuticals, Standardized Herbal extracts, and Bio-energetic Resonance Homeopathics and are traditionally believed to work by relieving the symptoms by strengthening the immune system and improving the functioning of the digestive system. (biogetica.com)
- MMP activity is counterbalanced by their four physiological inhibitors, the tissue inhibitors of MMP (TIMPs). (inserm.fr)
- MMP activity is counterbalanced by their physiological inhibitors, the tissue inhibitors of MMPs (TIMPs), a family of 4 secreted multifunctional proteins that have growth promoting activities. (biologie-journal.org)
- It has indeed become clear from investigations on various models that the adult nervous system can adapt to physiological demands by altering reversibly its synaptic circuits. (biologie-journal.org)
- In others, they can only be sold as supplements to support specific underlying systems and organs. (biogetica.com)
- Together, MMP and TIMP control cell-cell and cell-matrix interactions associated with physiological processes. (inserm.fr)
- Using this experimental system, we have shown the formation of intracellular vesicles, in which misfolded/unfolded HLA-B proteins accumulated when they were highly expressed, for both AS-associated alleles (HLA-B*2702, -05, et -07) or not (HLA-B*2706, et -09, HLA-B*0702). (oatd.org)
- In physiological conditions MMP activity is tightly regulated and altered MMP regulation is associated with pathological processes including inflammation, cell proliferation, cell death and tissue remodeling. (biologie-journal.org)
- Therefore, the quality of mental processes relies partly on the interaction between the brain's physiological maturation and individual daily experiences. (inserm.fr)
- use of Viagra (I am here including the 18 deaths that occurred during sexual intercourse, orsome time ago it was called â œimpotenzaâ today, with moreIn a recent audit of the quality management system certifi-based on the frequency of intake of the food. (rosengrenska.org)
- These results impact our understanding of multisensory interactions throughout the nervous system, where the information from different senses can modify the sensitivity of peripheral receptors. (federation3c.com)
- Appropriate communication between the immune and nervous systems is essential to maintain the homeostasis in presence of immunoreactive substances and when the organism is challenged by other types of neurogenic stimuli. (inserm.fr)
- We define motivation as a set of processes that assign values to potential situations. (paris-neuroscience.fr)
- START proteins act in a variety of distinct physiological processes, such as lipid transfer between intracellular compartments, lipid metabolism and modulation of signaling events. (medecinesciences.org)