OrganismesProduits chimiques et pharmaceutiquesSciences de l'information
IndolizidinesProsopisQuinolizidinesHydroxyde De SodiumEncyclopedias as TopicHexafluorure De SoufreAcide ChlorhydriqueChloruresMéthaneHygroscopic Agents

Allosteric modulation of the dopamine receptor by conformationally constrained type VI beta-turn peptidomimetics of Pro-Leu-Gly-NH2. (1/16)

A peptidomimetic of Pro-Leu-Pro-NH2, 7, possessing an indolizidinone type VI beta-turn mimic was synthesized via improved high-yielding protocols for the preparation and Cbz protection of alpha-allylproline. Bicyclic peptidomimetic 7 and spirobicylic peptidomimetic 8 enhanced the binding of [3H] N-propylnorapomorphine to dopamine receptors indicating that a type VI beta-turn is a possible bioactive conformation of the homochiral Pro-Leu-Pro-NH2 and Pro-Pro-Pro-NH 2 analogues of Pro-Leu-Gly-NH2 at the dopamine receptor allosteric regulatory site.  (+info)

Enantioselective synthesis of indolizidines bearing quaternary substituted stereocenters via rhodium-catalyzed [2+2+2] cycloaddition of alkenyl isocyanates and terminal alkynes. (2/16)

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Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. (3/16)

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Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus). (4/16)

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Evolution of multi-component anion relay chemistry (ARC): construction of architecturally complex natural and unnatural products. (5/16)

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Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa. (6/16)

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Total synthesis of indolizidine alkaloid (-)-209D: overriding substrate bias in the asymmetric rhodium-catalyzed [2+2+2] cycloaddition. (7/16)

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Asymmetric total synthesis of alkaloids 223A and 6-epi-223A. (8/16)

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