• structures
  • Unlike many other clearly defined supersecondary structures such as Greek keys or β hairpins, there are a number of types of zinc fingers, each with a unique three-dimensional architecture. (wikipedia.org)
  • TFIIIA) was due to the presence of zinc-coordinating finger-like structures. (wikipedia.org)
  • transcription
  • As zinc fingers are known to be involved in m-RNA regulation, reverse transcription, protection of synthesized viral DNA, transcription inhibition, and initial integration processes, prevention of zinc finger function can have drastic effects on the function of the cell or virus. (wikipedia.org)
  • fold
  • AN1-type zinc finger domains are widely present across diverse euryarchaeota and thaumarchaeota, where they are often fused to membrane-associated peptidase domains such as the rhomboid family serine peptidase, transglutaminase-like thiol peptidases of the papain fold, and Zn-dependent metallopeptidases. (wikipedia.org)
  • cell
  • In 1994, it was shown that an artificially-constructed three-finger protein can block the expression of an oncogene in a mouse cell line. (wikipedia.org)
  • site
  • Since the CCHC binding site is mutation resistant and involved in the replication of HIV-1, it makes a prime candidate for the prevention of HIV through zinc ejectors. (wikipedia.org)
  • This electrophilic interaction destabilizes the zinc binding site making it easier for the zinc ion to be withdrawn due to the new arrangement of bonds. (wikipedia.org)
  • The binding site then performs a disulfide exchange, forming new intermolecular disulfide bonds, and rearrangement occurs placing the zinc finger in a conformation that inhibits its function. (wikipedia.org)
  • research
  • We offer Zinc finger protein 639 Antibodies for use in common research applications: Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot. (novusbio.com)
  • five
  • When TFIIIA associates with DNA, it binds along the major groove with each finger binding about five nucleotides of DNA. (everything2.com)