Zebrafish. Medical search. Frequent questions

The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes. (wikipedia.org)
A new type of microscope has allowed scientists to map the behaviour and movements of cells during zebrafish ( Danio rerio ) embryonic development, and create a three-dimensional digital movie of the process. (nature.com)
The study of zebrafish ( Danio rerio ) cognition is being increasingly recognized for its complexity and the translational insights it offers into neurodevelopmental, neurodegenerative, and behavioral conditions. (biomedcentral.com)
This study examined the effects thyroid-active compounds during early development on body morphology of Zebrafish ( Danio rerio ). (usgs.gov)
Zebrafish (Danio rerio) is a small fish of the Cyprinidae family originating in the streams of India and Myanmar. (weizmann.ac.il)
The zebrafish, Danio rerio, possesses the paralogous genes aplnra and aplnrb that are duplicates of an ancestral orthologue of the human APLNR gene encoding a G-protein coupled receptor that binds the peptide ligand APELIN and is required for normal cardiovascular function. (nih.gov)
A zebra danio, or zebrafish, swims in a tank in a research institute in Wuhan in central China's Hubei province Thursday, April 22, 2021. (space.com)
Zebrafish, or Danio rerio, were earlier sent to the Soviet Union's Salyut 5 space station in 1976 aboard the Soyuz 21 mission. (space.com)
The zebrafish ( Danio rerio ) is an attractive and versatile model to gain insight into vertebrate brain development and function. (nature.com)
Zebrafish ( Danio rerio ) larvae provide a unique platform to study macrophage-microbe interactions in vivo , from the level of the single cell to the whole organism. (frontiersin.org)
E. J. Flynn, C. M. Trent and J. F. Rawls, "Ontogeny and Nutritional Control of Adipogenesis in Zebrafish (Danio rerio)," Journal of LIPID Research, Vol. 50, No. 8, 2009, pp. 1641-1652. (scirp.org)
Bioaccumulation: 'Flow through study with zebrafish (Danio rerio) kinetic BCF = 44. (janusinfo.se)

aplnrb is required for migration of cells contributing to heart development in zebrafish embryos. (nih.gov)
Blockage of translation of aplnra mRNA in zebrafish embryos results in retarded or failed epiboly with the blastoderm apparently disconnected from the nuclei of the yolk syncytial layer. (nih.gov)
Zebrafish embryos' hearts move incredibly quickly, beating three times per second. (ed.ac.uk)
Lxr ligand activation affected the expression of genes involved in lipid metabolism in zebrafish adult brain and eye as well as in zebrafish embryos. (scirp.org)
However, there is little information characterizing the toxic potency of PFECHS to zebrafish embryos and its potential for effects in aquatic environments. (acs.org)
Upon zTERT knockdown, zebrafish embryos show reduced telomerase activity and are viable, but develop pancytopenia resulting from aberrant hematopoiesis. (harvard.edu)
The blood cell counts in TERT-depleted zebrafish embryos are markedly decreased and hematopoietic cell differentiation is impaired, whereas other somatic lineages remain morphologically unaffected. (harvard.edu)
To complement the in vivo system of chick embryos, we employ patient omics data, single cell RNA sequencing, human and mouse embryos, human cancer cell cultures, human pluripotent stem cells, chick embryo neural crest-derived in vitro crestosphere cultures, and zebrafish and mouse in vivo models. (lu.se)

The transparent nature of zebrafish larvae, combined with their genetic tractability, presents a unique avenue to unravel the complexities of cognition at the neural circuitry level. (biomedcentral.com)
Zebrafish are also uniquely useful in biological research, partially because their larvae are transparent, allowing use of advanced visualization techniques to answer scientific questions in living animals. (nih.gov)
Small and large objects activate various circuits in the visual system of zebrafish larvae. (scitechdaily.com)
Knockdown of miR-10 led to premature truncation of intersegmental vessel growth (ISV) in the trunk of zebrafish larvae, while overexpression of miR-10 promoted angiogenic behavior in zebrafish and cultured human umbilical venous endothelial cells (HUVECs). (ca.gov)

The zebrafish also exhibits measurable behavioral and hormonal responses already at the larval stages, providing a viable vertebrate animal model for high-throughput drug screening and chemical genetics. (weizmann.ac.il)
Novel cross-regulation interactions between dlx genes in larval zebrafish. (nih.gov)
Here, we use drifting vertical gratings to evoke directed "fictive" swimming in intact but immobilized larval zebrafish while performing electrophysiological recordings from spinal neurons. (jneurosci.org)
Here we have developed a system using larval zebrafish that allows us to directly record electrical signals from spinal neurons during "fictive" swimming guided by visual cues. (jneurosci.org)
To assess and quantify specific behavioral paradigms, the group plans to utilize an automated assay that tracks the locomotor activity of hundreds of larval zebrafish. (sfari.org)
Using a combination of optical, behavioral and genetic approaches in the larval zebrafish, we describe a novel role for hypothalamic oxytocin (OXT) neurons in the processing of noxious stimuli. (iasp-pain.org)

Our guest this week is using young zebrafish to investigate how environmental factors affect their behavior, and whether behavioral changes can be attributed to specific brain activity. (apple.com)
Recognizing the lack of hands-on education, Dr. Kalueff has started organizing zebrafish behavioral neuroscience and phenotyping workshops. (noldus.com)
Behavioral profiles arising after exposure to psychoactive compounds will be compared in zebrafish containing mutations in ASD genes and in wildtype zebrafish. (sfari.org)
This technique allowed the researchers to analyze not just the behavioral characteristics of sleep such as muscle relaxation and decrease in heart rate, but also the neural signatures of sleep in the zebrafish brain. (nih.gov)
This manuscript describes the setup, implementation, and analysis of boldness, aggression, and shoaling in zebrafish and testing for the presence of a behavioral syndrome. (jove.com)
The overall goal of this protocol is to standardized the methodology used to observe, analyze and interpret boldness, aggression, shoaling behavioral syndromes in Zebrafish. (jove.com)
Our setups include custom-made behavioral arenas for zebrafish, brain imaging in zebrafish, psychophysics and virtual reality for humans and molecular biology. (fchampalimaud.org)

Using Zebrafish, researchers from the School of Neurobiology, Biochemistry and Biophysics at the Faculty of Life Sciences of Tel Aviv University have developed an advanced simulation of a key process in the brain - the activation of the stem cells responsible for generating neurons. (eurekalert.org)
Zebrafish were chosen because the stem cells in their brains are similar to those of mammals, but are much more numerous, so new neurons in their brains are constantly added. (eurekalert.org)
We observed miR-137 expression and activity in sensory neurons including Rohon-Beard neurons and dorsal root ganglia, two neuronal cell types that confer touch-sensitivity in normal zebrafish, suggesting a role of these cell types in the observed phenotype. (nature.com)
At the same time, after analyzing several molecular biomarkers of neuroinflammation, damage, and recovery of neurons, scientists were convinced that, unlike mammals, zebrafish are capable of full restoration of brain functions as early as a week after neuroinjury. (news-medical.net)
Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. (iasp-pain.org)
In vivo imaging revealed that a large and distributed fraction of zebrafish OXT neurons respond strongly to noxious inputs, including the activation of damage-sensing TRPA1 receptors. (iasp-pain.org)
Title : Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers After Cell Ablation Personal Author(s) : McPherson, Adam D.;Barrios, Joshua P.;Luks-Morgan, Sasha J.;Manfredi, John P.;Bonkowsky, Joshua L.;Douglass, Adam D.;Dorsky, Richard I. (cdc.gov)
Tiny zebrafish can also regrow parts of the eye, including neurons in the eye's retina (the light-sensitive tissue at the back of the eyeball). (medlineplus.gov)

The transparency of the zebrafish embryo allows real-time visualization of the development and morphogenesis of practically all of its tissues and organs. (weizmann.ac.il)
This force shapes the nervous system of the zebrafish embryo, a popular animal model of embryonic development. (ist.ac.at)
In the case of the zebrafish embryo, the tissues contact each other directly via E-cadherin, a protein that reaches out of the cells. (ist.ac.at)

A new study from the Max Planck Institute for Medical Research reveals how the eye of a zebrafish larva can already distinguish between prey and predator. (scitechdaily.com)
Scientists at the Max Planck Institute for Medical Research in Heidelberg have now shed light on how such circuits, which are likely to be crucial in classifying objects by size, function in the brain of the zebrafish larva. (scitechdaily.com)
The basic mechanisms of object classification can be studied using zebrafish larva as the model system. (scitechdaily.com)
These cells respond specifically to those object sizes that correspond to a small prey or a large troublemaker in the world of the zebrafish larva. (scitechdaily.com)

In this chapter, we describe the methodology for analyzing macrophages in various tissues in the adult zebrafish by flow cytometry . (bvsalud.org)

With the available tools of the genomic era and the abundance of disease-associated human genes yet to be explored, the zebrafish model is becoming the preferred choice in basic and applied life sciences. (weizmann.ac.il)
These approaches allow the Maves lab to use the zebrafish to understand how specific genes work to properly form the heart. (seattlechildrens.org)
The zebrafish shares 70 % of the genes found in humans and many critical signalling pathways. (europa.eu)
Hoffman's team aims to extend this work by investigating zebrafish with mutations in nine strong ASD candidate genes, previously identified from whole-exome sequencing of the Simons Simplex Collection (SSC) . (sfari.org)

The goal of the ZENITH ETN, "ZEbrafish Neuroscience Interdisciplinary Training Hub", is to understand how neural networks mediate perception and behavior. (europa.eu)
We will exploit the advantages of zebrafish as a small transparent vertebrate with superb genetic accessibility and use cutting-edge technology to elucidate the interactions between molecules, cells and entire networks that ultimately generate adaptive behavior. (europa.eu)
Discover the importance of zebrafish as a model organism in behavior research. (noldus.com)
Learn how studies on zebrafish can reveal valuable insights into genetic disorders, learning and memory, developmental biology and even social behavior. (noldus.com)
miR-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting VEGF Signaling. (ca.gov)
Genetic experiments in zebrafish revealed that miR-10 functions, in part, by directly regulating the level of a protein called FLT1, which inhibits the behavior of endothelial cells that promotes new blood vessel growth. (ca.gov)
The increase in FLT1/sFLT1 protein levels upon miR-10 knockdown in zebrafish and in HUVECs inhibited the angiogenic behavior of endothelial cells largely by antagonizing VEGF receptor-2 signaling. (ca.gov)

Zebrafish are very visually orientated, and their retina and lens show much the same morphology as other vertebrates including humans. (nih.gov)
Because the zebrafish genome and early heart development are very similar to that in humans, work in the Maves lab will have direct relevance for understanding human heart development and congenital heart defects. (seattlechildrens.org)
We also review novel aspects of macrophage biology revealed by zebrafish, which can potentiate development of new therapeutic strategies for humans. (frontiersin.org)
A simple ball of cells is the starting point for humans - and zebrafish. (ist.ac.at)
With the help of four students, Posner did gene-editing research during the fall 2021 semester on zebrafish, which builds its lens in a similar way to humans. (ashland.edu)
Read the article Zebrafish make a difference to find out more about Dr Love's work with zebrafish, and how useful these fish are anyway - they're very different from humans, after all! (sciencelearn.org.nz)
Zebrafish share neural and biochemical similarities with other vertebrates, including humans, that make them a potentially good model for studying sleep and sleep-related disorders. (nih.gov)
However, measuring the neural signatures of sleep in zebrafish has been technically challenging, and it was unknown whether or not they organize their sleep cycle similar to humans and other vertebrate animals. (nih.gov)
Given the zebrafish's place in the vertebrate family tree, these results suggest that common mechanisms of sleep are shared among animals as disparate as zebrafish and humans. (nih.gov)
Experts from the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal Traits translational Network") Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. (lu.se)

Funding for the single plane illumination microscope (SPIM) and advanced transgenic zebrafish used in these studies was provided by The BHF Centre of Research Excellence Award, University of Edinburgh. (ed.ac.uk)
Commonly, zebrafish macrophages are identified based on expression of fluorescent transgenic reporters, allowing for real- time imaging in living animals . (bvsalud.org)

The zebrafish is an important and widely used vertebrate model organism in scientific research, for example in drug development, in particular pre-clinical development. (wikipedia.org)
In recent years, the zebrafish has become a favourite model organism for biologists studying developmental processes in vertebrates. (nih.gov)
This review describes the advantages of the zebrafish as a model organism as well as giving an overview of eye development in this species. (nih.gov)
The study introduces a long-needed testable molecular reference paradigm of the mature zebrafish extended amygdaloid complex studying neural underpinnings and evolution of emotion in this important model organism. (frontiersin.org)
These findings suggest that zebrafish, and the novel imaging techniques possible in this model organism, could be powerful new tools for research to increase understanding of human sleep and its impacts on health and disease. (nih.gov)

Studies using zebrafish allow non-invasive, real-time visualization of macrophage recruitment and phagocytosis. (frontiersin.org)

BMC Neuroscience is now welcoming submissions to our Collection on zebrafish cognition. (biomedcentral.com)
The EU-funded ZENITH project is preparing a new generation of scientists for interdisciplinary collaboration on pressing neuroscience challenges utilising the zebrafish model system and leveraging academic and industrial mentoring. (europa.eu)

Furthermore, the chemical and genetic tractability of zebrafish has been central to decipher the complex role of macrophages during infection. (frontiersin.org)

Zebrafish widely used as an animal model in various fields of biomedical research as a disease model for cancer, metabolic and neurodegenerative diseases, and regenerative medicine. (weizmann.ac.il)

With their expertise in using CRISPR-Cas9 genome editing technology in zebrafish, the Maves lab have the capability to engineer knock-out and precise knock-in zebrafish strains. (seattlechildrens.org)

His lab is interested in uncovering the neural and molecular basis for individual differences in behaviour using adult zebrafish as a model system. (biomedcentral.com)
He also works to develop tools to enhance zebrafish behavioural neurobiology, such as a digital adult zebrafish brain atlas ( azba.wayne.edu ), tracking fish in 3D, and precision approaches for drug delivery. (biomedcentral.com)
Alterations in the length and position of paired fins caused by exposure to thyroid-disrupting chemicals during early development, as shown here for Zebrafish, could affect physical aspects of locomotion and consequently other important organismal functions such as foraging, predator avoidance, and ultimately survival and recruitment into the adult population. (usgs.gov)
By in situ hybridization we showed distinct expression of lxr in the brain and the retina in the developing and adult zebrafish. (scirp.org)
Isolation of Tissue Macrophages in Adult Zebrafish. (bvsalud.org)
Overall, we aim at providing a guide for the zebrafish community based on our expertise investigating the adult mononuclear phagocyte system . (bvsalud.org)

Understanding how zebrafish process their environment, make decisions, and engage in social behaviors allows us to shed light on the processes of neurogenesis that give rise to advanced thought. (biomedcentral.com)
Soviet cosmonauts conducting experiments with the fish found that the Zebrafish appeared to modify some of their behaviors in response to living in microgravity. (space.com)
The main advantage of this technique is that the boldness, aggression, shoaling combination encompasses many well studied, easily quantifiable behaviors in Zebrafish. (jove.com)

Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System. (nih.gov)
Using a high-throughput in vivo approach, Hoffman and her team previously identified dysfunction of excitatory and inhibitory systems in zebrafish lacking a functional autism risk gene, CNTNAP2 . (sfari.org)

A group of scientists, which included researchers from the Ural Federal University (UrFU), have developed and successfully tested a new model of traumatic brain injury (TBI) in zebrafish. (news-medical.net)
The most common experimental models of traumatic brain injury in both rodents and zebrafish, such as a mechanical blow to the head or piercing the brain with a needle, are associated with penetrating damage to brain tissue. (news-medical.net)
Due to the fact that the skin and skull of the used variety of zebrafish are transparent, scientists 'enlightened' the brain directly, and non-invasively. (news-medical.net)
The results obtained showed that, firstly, during the entire period of observation, microglia were activated in the brain of zebrafish. (news-medical.net)
Most of my students don't keep doing zebrafish research, but there have been a couple," Posner said about one who did his post-doctorate work with zebrafish at the Cleveland Clinic and another who had a research job with the National Institute of Health (NIH) using the small fish to study brain development before she went on to work in public health. (ashland.edu)
Researchers recently identified several neural activity signatures in the zebrafish brain that suggest certain sleep states in these fish are similar to human sleep and that they could thus be used for studying the role of sleep in health and disease. (nih.gov)
To explore this question, researchers sought to determine whether the zebrafish brain undergoes sleep states found in people and other vertebrates, such as the slow-wave and rapid eye movement (REM) states. (nih.gov)

Molecular characteristics such as the distribution of substance P and the calcium-binding proteins parvalbumin (PV) and calretinin (CR) indicate, that the zebrafish extended centromedial (autonomic and reproductive) amygdala is predominantly located in the GABAergic and isl1 -negative territory. (frontiersin.org)

This paper investigates the spatial dynamics of a zebrafish model with cross-diffusions. (aimsciences.org)

In an effort to identify elusive regulators of nephron segmentation, our lab conducted a high-throughput drug screen using a bioactive chemical library and developing zebrafish, which are a conserved vertebrate model and particularly conducive to large-scale screening approaches. (mdpi.com)

Zebrafish are a popular model of choice for many researchers, including chronobiologists. (noldus.com)
Collaborating researchers from the Centre for Cardiovascular Science and the University of Glasgow's School of Physics and Astronomy hope that by providing incredibly detailed time-lapse videos of growing zebrafish hearts, we can better understand the cellular and subcellular processes by which these hearts form and repair themselves. (ed.ac.uk)
While some 3D images of beating zebrafish hearts have been captured before, cardiac researchers have struggled to create useful 3D time-lapse videos of the heart growing over the course of a full day. (ed.ac.uk)
This new visualization technique also enabled the researchers to study and identify cellular and molecular regulators of zebrafish sleep, such as a hormone that controls the onset of propagating wave sleep. (nih.gov)

In 2015, a study was published about zebrafishes' capacity for episodic memory. (wikipedia.org)
Dr Kareklas is currently working with Prof Rui Oliveira at the Gulbenkian Science Institute, Portugal, using genetic zebrafish models to study neuromodulatory and neurodevelopmental mechanisms of sociality. (biomedcentral.com)
A new type of microscopy is helping scientists study the regenerative hearts of zebrafish. (ed.ac.uk)
The objective of this study was to determine the role of LXR during development using the zebrafish model. (scirp.org)
In the present study, Heisenberg and his group studied the mechanical forces that are at work when the central nervous system (CNS) of the zebrafish develops. (ist.ac.at)
All three of Posner's study leave work have been with eye research using zebrafish. (ashland.edu)
Thus, the study explains how the zebrafish amygdala and the complexly everted telencephalon topologically relate to the corresponding structures in mammals indicating that an elaborate amygdala ground plan evolved early in vertebrates, in a common ancestor of teleosts and tetrapods. (frontiersin.org)
Based on molecular and evolutionary-developmental characteristics, the study identifies the elaborate amygdala ground plan in zebrafish and stresses the evolution of a complex emotional system in early vertebrates. (frontiersin.org)
Dr Don Love and his Auckland University team use zebrafish to study heritable human diseases such as Duchenne muscular dystrophy, Huntington's disease, and inflammatory bowel disease. (sciencelearn.org.nz)

Zebrafish are amenable to genetic manipulation, for which innovative genetic and molecular techniques are constantly being introduced. (weizmann.ac.il)
Through molecular characterization and evolutionary-developmental considerations, we delineated the complex amygdala ground plan of zebrafish, whose everted telencephalon has made comparisons to the evaginated forebrains of tetrapods challenging. (frontiersin.org)
In this radical paradigm, thirteen telencephalic territories constitute the zebrafish amygdaloid complex and each territory is distinguished by conserved molecular properties and structure-functional relationships with other amygdaloid structures. (frontiersin.org)

2017). The not-so-long history of zebrafish research in Israel. (weizmann.ac.il)

Activity of dlx5a/dlx6a regulatory elements during zebrafish GABAergic neuron development. (nih.gov)

They utilize zebrafish as a model system, an amenable model due to large progenies that allow for the screening of hundreds of psychoactive molecules simultaneously. (sfari.org)

The more we know about zebrafish, the more clues we may have into our own neurobiology. (apple.com)

This Collection aims to showcase the most innovative new research on the neural networks shaping zebrafish cognition, as well as the impact of genetics, environment, and hormones on their cognitive skills, and insights gleaned from zebrafish models into the mechanisms of neurodevelopmental and neurodegenerative conditions. (biomedcentral.com)

Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish. (cdc.gov)

In particular, they are engineering zebrafish to carry DNA mutations that are found in human patients with heart defects. (seattlechildrens.org)

All research involving the use of zebrafish must have a protocol approved by the MBL Institutional Animal Care and Use Committee (IACUC) . (mbl.edu)
To this end, we conducted research on Zebrafish, in which the laboratory at the Pasteur Institute in France specializes. (eurekalert.org)
The aquatics facility at Seattle Children's Research Institute is well-equipped with tools for using CRISPR-Cas9 in zebrafish. (seattlechildrens.org)
I have been reading a lot about zebrafish research lately and I thought it would be nice to share some of my favorite articles with you. (noldus.com)
Zebrafish hearts are commonly used in cardiac research as models for the human heart. (ed.ac.uk)
Posner has been studying zebrafish since his post-doctoral days at UCLA in 1998, bringing that research to Ashland the following year when he joined the AU faculty. (ashland.edu)
He and his students have been working with zebrafish ever since - always eye research. (ashland.edu)
There are thousands of people worldwide who work on zebrafish," said Posner, who attends a national eye research meeting annually and zebrafish conferences regularly. (ashland.edu)

2018) In: Development and function of the zebrafish neuroendocrine system. (weizmann.ac.il)
Our data show that lxr is an important component of the regulatory network governing the lipid homeostasis during zebrafish development, which in turn may support a role of lxr for normal development of the central nervous sytem, including the retina. (scirp.org)
To further examine the role of telomerase during vertebrate development, the zebrafish telomerase reverse transcriptase (zTERT) was functionally characterized. (harvard.edu)
Tissue macrophages are essential components of the immune system that also play key roles in vertebrate development and homeostasis , including in zebrafish , which has gained popularity over the years as a translational model for human disease . (bvsalud.org)
Using fluorescently labeled nanocellulose we were able to show that nanocellulose uptake did occur in embryonic zebrafish during development. (cdc.gov)

2016). Zebrafish reel in phenotypic suppressors of autism. (weizmann.ac.il)

Kao RM, Rurik JG, Farr GH 3rd, Dong XR, Majesky MW, Maves L. Pbx4 is required for the temporal onset of zebrafish myocardial differentiation . (seattlechildrens.org)

Addgene: Adoption of the Q transcriptional regulatory system for zebrafish transgenesis. (addgene.org)

In particular, the Maves lab is able to engineer patient-specific fish, with the goal of using CRISPR-engineered zebrafish models to better understand human disease. (seattlechildrens.org)
Farr GH 3rd, Imani K, Pouv D, Maves L. Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects . (seattlechildrens.org)
Unlocking the secrets of zebrafish heart formation through these detailed images could, in turn, reveal more about how human hearts grow and heal. (ed.ac.uk)
Interestingly, while they are similar to human hearts, zebrafish hearts have the added ability to regenerate and heal themselves after injury. (ed.ac.uk)
In order to use zebrafish to help us better understand certain human diseases, the zebrafish need to be 'given' the diseases. (sciencelearn.org.nz)

That's because zebrafish rapidly develop their 'inner clock' (circadian system) - and because this system is highly light-entrainable. (noldus.com)

Here, we discuss the latest developments using zebrafish models of bacterial and fungal infection. (frontiersin.org)

They are taking advantage of CRISPR-Cas9 genome editing technology, and of zebrafish as an animal model system, to identify the genetic causes of congenital heart defects. (seattlechildrens.org)

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