Fatty acidsAcetic acidAmino acidsPeptidesMethyl esterNucleicCarboxylicProteinsDerivativesCompoundAdductsOxidationEstersHydrolysisCompoundsLewisGlycanAmidesReagentReactionOrganicSequenceChromatographicStirDerivativeHighMoleculesExtractionResearchGroupEssentialGoodConditionsCellGivePureProductsClassMethodsWater
Fatty acids4
- Whereas the trisaccharidic head group of Gb 3 defines the specificity of Shiga toxin binding, the lipophilic part composed of sphingosine and different fatty acids is suggested to determine its localization within membranes impacting membrane organisation and protein binding eventually leading to protein internalisation. (springer.com)
- The results clearly highlight the influence of the different fatty acids of the Gb 3 sphingolipids on the phase behaviour and the binding properties of Shiga toxin B subunits, even though the membranes were only doped with 5 mol% of the receptor lipid. (springer.com)
- This group of compounds includes amino acids and fatty acids. (lookformedical.com)
- Alkenes from unsaturated fatty acids and ceramides can also be converted to glycols by osmium tetroxide and then oxidized by periodate to aldehydes, and periodate will oxidize certain β-aminoethanol derivatives such as the hydroxylysine residues in collagen, as well as methionine (to its sulfoxide) and certain thiols (usually to disulfides). (thermofisher.com)
Acetic acid5
- Many amides can be reduced to amines by triacetoxyborohydride formed in situ from sodium borohydride and glacial acetic acid. (thevespiary.org)
- In many cases trifluoroacetic acid gives better yields than acetic acid. (thevespiary.org)
- The digestion mixture was then acidified by adding glacial acetic acid to a final concentration of 2% and desalted by SepPak column (Waters). (scienza-under-18.org)
- 7, diluted acetic acid, 0.1% trifluoroacetic acid in aqueous acetonitrile. (lifetein.com)
- Treatment of the maleimide adducts ( 8 ) with p -toluenesulfonic acid in boiling acetic acid gave the [2.3.4]cyclazines ( 9 ). (heterocycles.jp)
Amino acids4
- A class of amino acids characterized by a closed ring structure. (lookformedical.com)
- Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
- In PSII subunits, photo-oxidative modifications of several amino acids such as Trp have been indeed documented, whereas the linkage between such modifications and D1 degradation remains elusive. (elifesciences.org)
- Marcus et al, in international patent application WO 01/17563, describe specific anticancer activity for cytotoxic agents, such as campto-thecin, conjugated by means of a spacer, consisting of one or more amino acids, to a non-peptidic inhibitor antagonist of integrins av63 and CLvB5. (allindianpatents.com)
Peptides5
- CPP) and guanidinium-rich transporters serve as intracellular delivery vehicles for biologically relevant macromolecules such as peptides proteins and nucleic acids. (globaltechbiz.com)
- Peptides containing two or more thiol moieties may yield a mixture of products upon oxidation. (lifetein.com)
- This analysis strategy is called bottom-up or shot-gun proteomics and yields very complex samples consisting of up to several thousand peptides. (chromedia.org)
- The resulting tryptic peptides that are protonated at the amino acid of the C terminus, are readily separated on reversed phase C18 columns and easily detected by MS detection. (chromedia.org)
- The obtained MS/MS spectrum of the peptides giving information on the amino acid sequence of the protein, can be matched against databases to finalize identification. (chromedia.org)
Methyl ester1
- 15.E E. (Z)-2-tert-Butoxycarbonylamino-3-(4-carbamoyl-2,6-dimethyl-phenyl)acrylic acid methyl ester. (ambeed.com)
Nucleic2
- Extraction procedures are optimized to precipitate and remove proteins and nucleic acids while maximizing solubilization of GSLs along with other lipids. (springer.com)
- periodate-oxidized ribonucleotides can subsequently be converted to fluorescent nucleic acid probes by reaction with fluorescent hydrazines, hydroxylamines and amines. (thermofisher.com)
Carboxylic4
- Carboxylic acids. (lookformedical.com)
- Carboxylic acids can be saturated, unsaturated, or aromatic. (lookformedical.com)
- A visible-light-induced nickel-catalyzed cross coupling of alkyl carboxylic acids with N -trifluoroethoxyphthalimide is described. (beilstein-journals.org)
- Under purple light irradiation, an α-hydroxytrifluoroethyl radical generated from a photoactive electron donor-acceptor complex between Hantzsch ester and N -trifluoroethoxyphthalimide was subsequently engaged in a nickel-catalyzed coupling reaction with in situ-activated alkyl carboxylic acids. (beilstein-journals.org)
Proteins2
- These compounds are highly reactive electrophiles that form stable adducts to a variety of available amino acid residues on proteins upon exposure. (cdc.gov)
- Prolamin proteins define nutritional value of maize grain not only via amino acid quality but also via starch availability. (intechopen.com)
Derivatives3
- Trifluoroethanol is produced industrially by hydrogenation or the hydride reduction of derivatives of trifluoroacetic acid, such as the esters or acyl chloride. (wikipedia.org)
- To obtain fluorescent Gb 3 derivatives, either fatty acid labelled Gb 3 molecules or head group labelled ones were synthesized. (springer.com)
- It has now been found that 7-t-butoxyiminomethylcamptothecin conjugated in position 20, possibly by means of suitable spacers, to cyclopep-tide derivatives containing the RGD sequence yields compounds endowed with high, selective anticancer activity which can be advantageously used for the preparation of medicaments for the treatment of tumours. (allindianpatents.com)
Compound4
- This reaction, as illustrated in Scheme 3, involves the creation of coumarin-based derivative by conjugating a phenolic compound with dicarboxylic acid-containing derivative using concentrated inorganic acid like HCl or H 2 SO 4 as a promoter [22]. (jmchemsci.com)
- Subsequent 1 3 cycloaddition of 9 with a propargylamide-extended biotin followed by deprotection using trifluoroacetic acid yielded compound 2 (Scheme 1). (globaltechbiz.com)
- After two classical peptide coupling reactions and one hydrolysis reaction, compound Ia - Ie were obtained in moderate yields. (biomedcentral.com)
- In spite of inefficient hydrolysis of 1-(2-aminophenyl)-2,2,3,3,4,4,4-heptafluorobutan-1-one diethyl acetal ( 2 ), this compound undergoes readily the acid-catalyzed Friedländer reaction with enolizable ketones to give the corresponding quinolines ( 4 - 6 ). (heterocycles.jp)
Adducts1
- TFE forms complexes with Lewis bases such as THF or pyridine through hydrogen bonding, yielding 1:1 adducts. (wikipedia.org)
Oxidation1
- Oxidation of trifluoroethanol yields trifluoroacetic acid. (wikipedia.org)
Esters1
- To further demonstrate the utility of THNAPhos in asymmetric hydrogenation, in this paper, we describe its new application in the asymmetric hydrogenation of alpha-dehydroamino acid esters, enamides, dimethyl itaconate and alpha-enamido phosphonates. (idexlab.com)
Hydrolysis2
- The methods used were Driselase digestion and trifluoroacetic acid (TFA) hydrolysis. (bl.uk)
- Driselase digestion of cell walls produces disaccharides characteristic of some of the major cell wall polysaccharides, while hydrolysis with TFA yields monosaccharides. (bl.uk)
Compounds3
- The Pechmann reaction is claimed to be the most suitable synthetic pathway in the synthesis of coumarin-derived compounds which gives a promising yield towards the target product. (jmchemsci.com)
- Few organofluorine compounds exist naturally ( C&EN, May 22, page 12 ), meaning that almost all must be made. (acs.org)
- By virtue of their selective cytotoxic activity on tumour cells, the compounds according to the present invention yield medicaments with fewer and less severe side effects. (allindianpatents.com)
Lewis3
- It is classified as a hard Lewis acid and its acceptor properties are discussed in the ECW model yielding EA = 2.07 and CA = 1.06. (wikipedia.org)
- After prosperous domino reactions towards benzopyrans, the products were used as the starting material in Lewis acid catalyzed and organocatalytic Diels-Alder reactions to build up a tricyclic system. (beilstein-journals.org)
- Inorganic acids such as trifluoroacetic, hydrochloric, phosphoric, and sulfuric acids as well as Lewis acids such as the chlorides of tin (IV), iron (III), zinc, and titanium may fall in the first category [23]. (jmchemsci.com)
Glycan2
- Based on the ganglio GSL series, gangliosides are synthesized, where sialic acids are linked to the glycan structure to produce negatively charged GSLs. (springer.com)
- Moreover, at molecular level, each heparan sulfate proteoglycan (HSPG) consists of a core protein linked to one or more linear heparan sulfate (HS) chains composed of alternating D-glucosamine and uronic acids, leading to N - or O -sulfated glycan [ 5 ]. (biomedcentral.com)
Amides1
- The zwitterionic pyrido[2,1- f ]- as -triazinium-4-olates ( 1a - b ) and as -triazino[6,1- a ]isoquinolinium-1-olate ( 10 ) were photolysed to give acid amides ( 5 ) and ( 11 ), respectively. (heterocycles.jp)
Reagent2
- After separation by TLC, 10 -12 -10 -9 mol quantities of GSL can be chemically detected with orcinol, a reagent for hexoses and with resorcinol-HCl, a reagent for sialic acid. (springer.com)
- Polyphenols found in the enzyme preparation were found to interfere with the reduction of the dinitrosalicylic acid reagent. (who.int)
Reaction5
- Several advanced innovations have been created to maximize yield, minimize overall reaction time, avoid side products, and make synthetic reactions environmentally friendly. (jmchemsci.com)
- The transitional reaction intermediate named ortho-hydroxycinnamic acid affords the target product via a spontaneous lactonization [19]. (jmchemsci.com)
- The most notable failure of this reaction is the fakir yield, due to high heating applied, resulting from the production of numerous byproducts. (jmchemsci.com)
- Treatment of 2,3-dihydro-2-methyl-3-phenyl-1 H -pyrazino[3,4,5- cd ]indolizine 2-oxides ( 5 ) with trifluoroacetic anhydride gave new heterocyclic six-membered betaines ( 6 ) which underwnet 1,3-dipolar cycloaddition reaction with dimethyl acetylenedicarboxylate and maleimides in hot toluene to yield the corresponding cycloadducts ( 7 ) and ( 8 ). (heterocycles.jp)
- The reaction of 2 with pentanal yields quinoline ( 12 ) as the major product. (heterocycles.jp)
Organic1
- By this method, an ultrathin selective layer is formed on a porous support, by reacting classical monomers such as m-phenylene diamine (MPD) dissolved in water in contact with solutions of acid chlorides (e.g., trimesoyl chloride, TMC) in a nonpolar-organic solvent. (nature.com)
Sequence1
- The modular synthesis is based on Suzuki cross-coupling of the aryl substituents as boronic acid precursors with 5,8-dibromo-2-( tert -butyl)-4,9-dimethoxy-2,3-dihydro-1H-phenalen-1-one, and the subsequent transformation of the product to the desired 2,5-diaryl 6-hydroxyphenalenone in a reduction/deprotection sequence. (thieme-connect.com)
Chromatographic1
- Tri-fluoroacetic acid has a lower UV absorption at 214 nm and results in optimal chromatographic performance. (chromedia.org)
Stir1
- When the acid has been added the mixture is allowed to stir for one hour with or without heating. (thevespiary.org)
Derivative1
- A cyclized derivative of L-GLUTAMIC ACID. (lookformedical.com)
High2
- Since the concept was first coined in 2001, the surging interest in AIE research has led to diverse AIE luminogens (AIEgens) with tunable emissions and high quantum yields approaching unity in the solid state. (european-mrs.com)
- The reactive intermediates were efficiently trapped by dienophiles, such as N -phenylmaleimide and diethyl azodicarboxylate, to form [4+2] cycloaddition products in high yields. (heterocycles.jp)
Molecules1
- Special emphasis is put on the preparation of Gb 3 molecules differing only in their fatty acid part (saturated, unsaturated, α-hydroxylated and both, unsaturated and α-hydroxylated). (springer.com)
Extraction1
- In particular, the extraction yield and selectivity were evaluated and compared with conventional green extractions (hot water and a hydroalcoholic solution). (frontiersin.org)
Research1
- Continuous research has yielded breakthroughs in coating materials, including nanocoatings and intelligent coatings, further expanding the realm of possibilities. (thetribunecity.com)
Group1
- Due to the fact the 3-amino group for the 2-deoxystreptamine primary of neomycin is the least basic and nucleophilic out of the 6 amines [15] we rationalized that very mild guanidinylation conditions would yield the partially guanidinylated product leaving this group intact. (globaltechbiz.com)
Essential1
- A non-essential amino acid that is synthesized from GLUTAMIC ACID. (lookformedical.com)
Good2
- Good results are obtained with tri-fluoroacetic acid and formic acid. (chromedia.org)
- This convenient protocol does not require photocatalysts and metal reductants, providing a straightforward and efficient access to trifluoromethyl alkyl acyloins in good yields with broad substrate compatibility. (beilstein-journals.org)
Conditions1
- Coatings yield water-resistant and breathable fabrics, equipping outdoor apparel with protection against varied weather conditions. (thetribunecity.com)
Cell1
- These strains with genome reductions ranging in size from 581.9 to 814.4 kb displayed markedly decreased growth rates, sporulation ratios, transformation efficiencies and maintenance coefficients, as well as increased cell yields. (biomedcentral.com)
Give1
- The solvent was removed under reduced pressure to give a crude residue which was purified by flash silica gel chromatography (eluent: ethyl acetate/petroleum ether (v:v= 1: 2)) to give AU (yield: 98percent) as a colorless oil. (ambeed.com)
Pure1
- The yields of pure natural octapeptin C4 and Micafungin and MX-2401 analogues were 18.0%, 26.0% and 15.0% respectively. (ukdiss.com)
Products1
- Furthermore, trifluoroacetic acid was able to be used in the mobile phase with UVLC-MMS to improve the separation of differentially reduced intact species and detectability of the droplet-digested products. (bvsalud.org)
Class1
- Octapeptin C4 is a member of the octapeptin class, having a 3-hydroxy-decanoic acid moiety attached to the core structure [13, 23] (Fig. 2) . (ukdiss.com)
Methods1
- Assessment of immunoaffinity (anti-phosphotyrosine antibody) versus chemical (TiO2) enrichment methods, as well as solitary versus dual enrichment strategies, yielded an initial assessment of the phosphoprotein/peptide content of human being serum, which can serve as a launch-point for further exploration and analysis. (scienza-under-18.org)
Water1
- Most of the mechanisms described in literature are based on co-initiation by impurities, including water or lactic acid. (anon.co.kr)