• strains
  • Thus, sequencing Venezuelan YFV strains over a wide geographic area and temporal distribution might be valuable to test the hypothesis of local maintenance in Venezuela and to determine whether the virus moves regularly between Trinidad and Venezuela or between Venezuela and Brazil. (thefreelibrary.com)
  • This antibody is specific for the envelope protein of the wild (Asibi) and vaccine strains of yellow fever virus. (genetex.com)
  • This suggested that the YF virus strains isolated from the same geographic area and during a short period of time had evolved slowly. (ajtmh.org)
  • This reaction, called YEL-AVD, causes a fairly severe disease closely resembling yellow fever caused by virulent strains of the virus. (wikipedia.org)
  • 2001
  • The article begins by stating that of the 7 people who developed system failure within 2 to 5 days of the vaccine in 1996-2001, 6 died "including 2 who were vaccinated even though they were planning to travel to countries where yellow fever has never been reported. (wikipedia.org)
  • epidemic
  • During the Yellow Fever Epidemic of 1793 in Philadelphia, 5,000 or more people were listed in the official register of deaths between August 1 and November 9. (wikipedia.org)
  • The vast majority of them died of yellow fever, making the epidemic in the city of 50,000 people one of the most severe in United States history. (wikipedia.org)
  • They crowded the port of Philadelphia, where the first yellow fever epidemic in 30 years began in the city in August. (wikipedia.org)
  • In 1998 an epidemic of yellow fever killed many Howler monkeys near the city of Altamira, Pará in the eastern Amazon basin, in Brazil. (wikipedia.org)
  • The Yellow Fever Epidemic of 1793 struck during the summer in Philadelphia, Pennsylvania, where the highest fatalities in the United States were recorded. (wikipedia.org)
  • In 1802-1803, an army of forty thousand sent by First Consul Napoleon Bonaparte of France to Saint Domingue to suppress the Haitian Revolution mounted by slaves, was decimated by an epidemic of yellow fever (among the casualties was the expedition's commander and Bonaparte's brother-in-law, Charles Leclerc). (wikipedia.org)
  • outbreak
  • In December 2016, Brazil reported the country's largest yellow fever (YF) outbreak in decades. (cdc.gov)
  • When mass amounts of brown howlers are found dead it is a good inclination that there may be a yellow fever outbreak occurring. (wikipedia.org)
  • A preliminary finding that the strain of the yellow fever virus was closely related to a strain identified in a 1971 outbreak in Angola was confirmed in August 2016. (wikipedia.org)
  • On 20 June, the health minister declared the outbreak of yellow fever in three provinces, including the capital of DR Congo, Kinshasa. (wikipedia.org)
  • Spanish colonists recorded an outbreak in 1648 on the Yucatan peninsula of Mexico that may have been yellow fever. (wikipedia.org)
  • 2016
  • On 20 January 2016, the health minister of Angola reported 23 cases of yellow fever with 7 deaths among Eritrean and Congolese citizens living in Angola in Viana municipality, a suburb of the capital of Luanda. (wikipedia.org)
  • On 22 March April 2016, the WHO was notified of 21 deaths from yellow fever in the Democratic Republic of the Congo, some in a province that borders Angola. (wikipedia.org)
  • envelope
  • Inside the endosome, the decreased pH induces the fusion of the endosomal membrane with the virus envelope. (wikipedia.org)
  • closely
  • Moreover, all the viruses were closely related and no correlation could be established with the apparent variations in virulence in nature. (ajtmh.org)
  • bacteria
  • and he wanted to test the hypothesis that yellow fever was caused by spirochaete bacteria instead of a virus. (wikipedia.org)
  • In simple terms, physical barriers prevent pathogens such as bacteria and viruses from entering the organism. (wikipedia.org)
  • In leafminers of the species Phyllonorycter blancardella, Wolbachia bacteria help their hosts produce green islands on yellowing tree leaves, that is, small areas of leaf remaining fresh, allowing the hosts to continue feeding while growing to their adult forms. (wikipedia.org)
  • Isolation
  • 1. Isolation and characterization of yellow fever vaccine (YFV-17D) specific adaptive immune responses: characterize the magnitude and quality of YFV specific T cell responses, antibody secreting cells and memory B cells. (clinicaltrials.gov)
  • 1957. Isolation of Ilhéus Virus from Sabethes chloropterus captured in Guatemala in 1956. (wikipedia.org)
  • NS4B
  • Selection and genetic analysis of drug resistant viruses revealed that substitution of proline at amino acid 219 (P219) of the nonstructural protein 4B (NS4B) with serine, threonine or alanine confers YFV resistance to BDAA without apparent loss of replication fitness in cultured mammalian cells. (physiciansweekly.com)
  • antiviral
  • Yellow fever is among one of the most lethal viral diseases for which approved antiviral therapies were yet to be discovered. (springer.com)
  • Thus, the 10 lead molecules suggested in the present study would be of interest as promising starting point for designing antiviral compound against yellow fever. (springer.com)
  • Although a highly effective vaccine is available, the number of yellow fever cases has increased over the past two decades, which highlights the pressing need for antiviral therapeutics. (physiciansweekly.com)
  • The encouraging preclinical results thus warrant further development of BDAA or its derivatives as antiviral agents to treat yellow fever. (physiciansweekly.com)
  • We have thus reached a critical milestone toward the development of specific antiviral therapeutics for clinical management of yellow fever. (physiciansweekly.com)
  • victims
  • Adding to the alarm was that, unlike with most fevers, the principal victims were not the very young or very old. (wikipedia.org)
  • immune
  • The objective of this study is to study immune memory generated against the yellow fever vaccine (YFV) in participants who recently received the YFV vaccine. (clinicaltrials.gov)
  • To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. (wikipedia.org)