DiseasesChemicals and DrugsDisciplines and OccupationsAnthropology, Education, Sociology and Social Phenomena
LoperamideAntidiarrhealsThiorphanSenna ExtractDiarrheaNaloxoneForensic PathologyCastor OilPiperidines
IMODIUMHydrochlorideAntidiarrhealDiarrheaTabletsCapsulesDiarrhoeaOpioidsToxic megacolonIntentionalConstipationAnti-DiarrhealDosesDrugsMedication2016IntestinesCardiacDiphenoxylateAcuteDoseRatsChronicCapsuleEuphoriaAntibioticOpioid withdrawalDiscontinueTreatmentOralSuitable for childrenSerious adverseAdverseMedicationsDRUGCentersTravelersMedicinesTherapeuticChildrenExposurePatientsElderlyClinicalCautionAbdominal pain1995FrequentSwedenIntestinalAbuse
IMODIUM42
Hydrochloride6
  • Each capsule contains loperamide hydrochloride to help restore normal bowel function and reduce the frequency of loose stools. (pharmacyprime.com)
  • Each capsule contains loperamide hydrochloride. (pharmacyprime.com)
  • Amazon has the 24-Pack Amazon Basic Care 2mg Loperamide Hydrochloride Anti-Diarrheal Tablets for $2.93 - 5% off with Subscribe & Save (can cancel at any time) = $2.78 with free shipping on $25+ or with Prime. (shopmiee.com)
  • Loperamide hydrochloride is head and shoulders above everything else in its efficacy," said Randy Ongie, key account manager at Millbrook Distribution Services, Johnson City, Tenn. (supermarketnews.com)
  • There have been isolated reports of obstipation with an increased risk for toxic megacolon in AIDS patients with infectious colitis from both viral and bacterial pathogens treated with loperamide hydrochloride. (medicines.org.uk)
  • Loperamide hydrochloride, carmine and carboxymethylcellulose were procured from Sigma Chemical Co., St Louis, MO, USA while senokot was a product of Reckitt Benckiser Pharmaceutical (Pty) Ltd, South Africa. (biomedcentral.com)
Antidiarrheal3
  • Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties. (cdc.gov)
  • In 1990, all formulations for children of the antidiarrheal loperamide were banned in Pakistan. (wikipedia.org)
  • Perspectives of and experience toward the abuse of antidiarrheal drug (loperamide) among community pharmacists: a cross-sectional study - Barakat M, Akour A, Malaeb D, Cherri S, Al Safadi W, Al Safadi A, Wazaify M. (medworm.com)
Diarrhea15
  • Loperamide is effective for the treatment of a number of types of diarrhea. (wikipedia.org)
  • Off-label uses for loperamide also include chemotherapy-induced diarrhea, especially related to irinotecan use. (wikipedia.org)
  • Loperamide should not be used as the primary treatment in cases of bloody diarrhea, acute exacerbation of ulcerative colitis, or bacterial enterocolitis. (wikipedia.org)
  • If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as E. coli O157:H7 or Salmonella, loperamide is contraindicated as a primary treatment. (wikipedia.org)
  • The study reported that the use of loperamide should be contraindicated in children who are under 3, systemically ill, malnourished, moderately dehydrated, or have bloody diarrhea. (wikipedia.org)
  • For adults and children 12 years of age and older who have acute or chronic diarrhea, the recommended dose of loperamide is a starting dose of 4 mg, followed by a 2 mg dose after each loose bowel movement (or bout of diarrhea). (medbroadcast.com)
  • Children 6 to 12 years of age (10 kg to 20 kg) can use this medication for acute or chronic diarrhea if recommended by a doctor. (medbroadcast.com)
  • Loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. (medscape.com)
  • Loperamide is used to control and relieve the symptoms of acute diarrhea. (mayoclinic.org)
  • Loperamide helps stop diarrhea by slowing down the movements of the intestines. (mayoclinic.org)
  • Loperamide has been a safe and effective treatment for diarrhea for many years. (medworm.com)
  • SYRACUSE, N.Y.-- Loperamide, a key ingredient found in over-the-counter anti-diarrhea medications is increasingly being abused by people attempting to self-treat their opioid addiction, with sometime fatal results, according to a study by the Upstate New York Poison Center, published online in Annals of Emergency Medicine . (upstate.edu)
  • The #1 Loperamide Diarrhea brand in the Philippines. (filipinogoodsusa.store)
  • Two of those alternatives-loperamide, an over-the-counter opioid used to treat diarrhea, and kratom, a widely available herbal substance containing the opioid mitragynine-were associated with disproportionate reports of ventricular arrhythmias and cardiac arrest in pharmacovigilance databases from the US and Canada between 2015 and 2021. (tctmd.com)
  • Therapeutic efficacy of single-dose rifaximin (550 mg) with loperamide in treating acute watery diarrhea compared to single-dose azithromycin (500 mg) with loperamide. (who.int)
Tablets5
  • The average loperamide dose was 196.5 mg (range = 2-1,200 mg), and nearly all cases (95%) involved tablets or capsules. (cdc.gov)
  • Loperamide tablets and capsules are not suitable for children under the age of 6 years old. (medbroadcast.com)
  • The expiration date for tablets and creams can be found on either the top or side panels of the container carton in the format [YEAR/MO]. (cpsc.gov)
  • Contact us if you need more details on Loperamide Tablets. (cn-medicines.com)
  • We are ready to answer your questions on packaging, logistics, certification or any other aspects about 2mg Loperamide Tablets、10blister/Box Loperamide Tablets. (cn-medicines.com)
Capsules2
  • Loperamide capsules are available over-the counter or with your doctor's prescription. (mayoclinic.org)
  • Adults and children 13 years of age and older-At first, 4 milligrams (mg) (2 capsules) after the first loose bowel movement, then 2 mg (1 capsule) after each loose bowel movement after the first dose has been taken. (mayoclinic.org)
Diarrhoea3
  • Loritax Loperamide offers effective relief from diarrhoea symptoms. (pharmacyprime.com)
  • For the symptomatic treatment of acute diarrhoea in adults and children aged 12 years and over. (medicines.org.uk)
  • For the symptomatic treatment of acute episodes of diarrhoea associated with Irritable Bowel Syndrome in adults aged 18 years and over following initial diagnosis by a doctor. (medicines.org.uk)
Opioids1
  • The ensuing years saw the aggressive marketing of prescription opioids, sparking the epidemic of opioid-related overdoses and deaths that continues to this day. (tctmd.com)
Toxic megacolon2
  • Loperamide treatment is not used in symptomatic C. difficile infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. (wikipedia.org)
  • A 76-year-old female with a past medical history of vascular dementia, stage 3 chronic kidney disease, hypertension, congestive heart failure, and Clostridium difficile toxic megacolon status post total colectomy with ileostomy presented with a 3-day history of fever, chills, dyspnea, and altered mentation. (hindawi.com)
Intentional5
  • Cases of intentional loperamide abuse reported to the National Poison Database System (NPDS) also were analyzed for demographic, dose, formulation, and outcome information. (cdc.gov)
  • A New York case of loperamide abuse was defined as any call to the Upstate New York Poison Center or New York City Poison Control Center reporting intentional loperamide abuse during January 1, 2008-March 31, 2016. (cdc.gov)
  • An NPDS loperamide abuse case was defined as any exposure reported to NPDS citing intentional loperamide abuse during January 1, 2008-March 31, 2016. (cdc.gov)
  • However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported. (medworm.com)
  • The Upstate New York Poison Center experienced a seven-fold increase in calls related to loperamide abuse or misuse from 2011 through 2015, which is consistent with national poison data, that reported a 71 percent increase in calls related to intentional loperamide exposure from 2011 through 2014. (upstate.edu)
Constipation4
  • Discontinue loperamide immediately if constipation occurs. (medscape.com)
  • These medicines can cause constipation or intestinal blockage if taken by children younger than 6 years old. (myhealth.gov.my)
  • was studied against loperamide-induced constipation in Wistar rats. (biomedcentral.com)
  • Constipation was induced by oral administration of loperamide (3 mg/kg body weight) while the control rats received normal saline. (biomedcentral.com)
Anti-Diarrheal1
  • Loperamide is a non-prescription anti-diarrheal agent targeting µ-opioid receptors in the intestinal tract. (escholarship.org)
Doses4
  • recent reports suggest that large doses (50-300 mg) of loperamide produce euphoria, central nervous system depression, and cardiotoxicity ( 2 - 4 ). (cdc.gov)
  • Loperamide is safe in therapeutic doses but extremely dangerous in high doses. (upstate.edu)
  • The paper outlines two case studies of patients with histories of substance abuse who attempted to self-treat opioid addictions with massive doses of loperamide. (upstate.edu)
  • Though loperamide, when taken at high doses, has been linked to dangerous arrhythmias before-with the FDA issuing a safety alert in 2016-these data newly call into question previous assertions that kratom may be relatively safe because it has not been associated with many reports of QTc prolongation. (tctmd.com)
Drugs1
  • Loperamide may interact with certain prescription drugs. (nih.gov)
Medication2
  • Loperamide is available as a generic medication. (wikipedia.org)
  • A majority of user-generated content pertaining to loperamide discussed using the medication to self-treat opioid withdrawal (70 percent). (upstate.edu)
20161
  • The use of loperamide has been considered to result in low risk of environmental impact (2016). (janusinfo.se)
Intestines1
  • Some strains of Y. enterocolitica can produce a heat-stable enterotoxin (Yst) that causes fluid secretion in the intestines. (stemcelldaily.com)
Cardiac6
  • These cases support the reported association between loperamide abuse and cardiac toxicity. (cdc.gov)
  • The potential mechanisms behind loperamide-induced cardiac arrhythmias associated with human abuse and extreme overdose - Lu HR, Damiano BP, Kreir M, Rohrbacher J, van der Linde H, Saidov T, Teisman A, Gallacher DJ. (medworm.com)
  • We evaluated loperamide in in vitro and in vivo cardiac safety. (medworm.com)
  • Health care providers must be aware of increasing loperamide abuse and its under recognized cardiac toxicity. (upstate.edu)
  • Loperamide also was tied to increased reporting of QTc prolongation/torsade de pointes, which could lead to sudden cardiac death, according to researchers led by Mori Krantz, MD, who conducted the study while working for Clario, a healthcare research technology company involved in clinical trials. (tctmd.com)
  • Within FAERS, the largest database, the researchers uncovered 1,163 reports of ventricular arrhythmia/cardiac arrest involving methadone, 1,008 involving loperamide, and 46 involving kratom (mitragynine) between 2015 and 2021. (tctmd.com)
Diphenoxylate2
  • Loperamide is often compared to diphenoxylate. (wikipedia.org)
  • The patient had required multiple hospital admissions for severe dehydration due to high-output ileostomy loss despite loperamide and atropine-diphenoxylate therapy. (hindawi.com)
Acute1
  • Most of these reports occurred in the setting of acute dysentery, overdose, and with very young children less than two years of age. (wikipedia.org)
Dose6
  • For children 6 to 8 years old (or weighing 20 kg to 30 kg) the recommended dose for the first day is 2 mg twice daily. (medbroadcast.com)
  • For children 8 to 12 years of age who weigh over 30 kg, the recommended dose for the first day is 2 mg 3 times daily. (medbroadcast.com)
  • For children 2 to 5 years old the dose is based on body weight and will be calculated by your child's doctor. (medbroadcast.com)
  • For liquid forms of loperamide, use a syringe to measure each dose as this gives a more accurate measurement than household teaspoons. (medbroadcast.com)
  • Children 9 to 11 years of age-The usual dose is 2 mg (1 tablet) after the first loose bowel movement, and 1 mg (½ tablet) after each loose bowel movement after the first dose has been taken. (mayoclinic.org)
  • Children 2 years of age and older-Use and dose must be determined by your doctor. (mayoclinic.org)
Rats2
  • Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans. (aspetjournals.org)
  • The present study was therefore, designed to evaluate the laxative activity of the aqueous leaf extract of Aloe ferox on loperamide-induced constipated rats and the effect was compared with senokot, a standard laxative drug. (biomedcentral.com)
Chronic1
  • Here we report the case of a 30-year-old woman presenting with syncope, who was found to have severe myocardial conduction delays in the setting of chronic loperamide abuse. (escholarship.org)
Capsule1
  • Children 8 to 12 years of age weighing more than 30 kilograms (kg)-2 mg (1 capsule) 3 times a day. (mayoclinic.org)
Euphoria1
  • People looking for either self-treatment of withdrawal symptoms or euphoria are overdosing on loperamide with sometimes deadly consequences. (upstate.edu)
Antibiotic1
  • For instance, intestinal E. coli infections caused by Shiga toxin-producing E. coli , or STEC - which spurs an estimated 265,000 foodborne infections each year in the United States - does not require antibiotic treatment. (everydayhealth.com)
Opioid withdrawal2
  • Abuse of loperamide for its euphoric effect or for self-treatment of opioid withdrawal is increasing ( 5 ). (cdc.gov)
  • Opioid withdrawal symptoms after cessation of loperamide were reported by nine patients. (cdc.gov)
Discontinue1
  • Participants were randomly assigned to continue tamoxifen up to 10 years or to discontinue the treatment at randomization. (bvsalud.org)
Treatment2
  • doc says can last 1 - 1 1/2 years after final treatment or forever. (cancer.org)
  • The increasing popularity of kratom led the investigators to wonder whether it might carry a risk of arrhythmias similar to those seen previously with loperamide and methadone, an opioid used for the treatment of morphine or heroin addiction. (tctmd.com)
Oral2
  • Children 2 to 5 years of age weighing 20 kg or less-Use the oral solution. (mayoclinic.org)
  • Oral loperamide abuse postings to web-based forums increased 10-fold between 2010 and 2011. (upstate.edu)
Suitable for children1
Serious adverse1
  • A review of loperamide in children under 12 years old found that serious adverse events occurred only in children under three years old. (wikipedia.org)
Adverse1
  • Health care providers and public health officials should remain vigilant for loperamide abuse and report adverse events to the U.S. Food and Drug Administration's MedWatch reporting system ( http://www.fda.gov/Safety/MedWatch external icon ). (cdc.gov)
Medications1
DRUG1
  • In the U.S., loperamide is classified by the U.S. Food and Drug Administration (FDA) as pregnancy category C. Studies in rat models have shown no teratogenicity, but sufficient studies in humans have not been conducted. (wikipedia.org)
Centers1
  • The objective of this study is to investigate the characteristics and trends of loperamide cases reported to United States (US) poison centers and to evalu. (medworm.com)
Travelers2
  • Ms. Holton has worked for CDC since 2000, spending the past ten years focused on travelers' health. (cdc.gov)
  • People are sometimes surprised to hear how many US travelers actually leave the country every year. (cdc.gov)
Medicines3
  • These medicines should not be taken by children below two years old and may only be taken by children aged 2 to 6 years old with doctor's supervision. (myhealth.gov.my)
  • Avoid taking medicines in front of children younger than 4 years old. (myhealth.gov.my)
  • Loperamide is not included in the WHO list of essential medicines. (msf.org)
Therapeutic1
  • Serum loperamide concentrations were obtained from four patients and ranged from 77-210 ng/mL, representing 25-875 times the therapeutic range of 0.24-3.1 ng/mL ( 6 ). (cdc.gov)
Children15
  • The use of loperamide in children under two years is not recommended. (wikipedia.org)
  • The National Health Service in the United Kingdom recommends that loperamide should only be given to children under the age of twelve if prescribed by a doctor. (wikipedia.org)
  • According to World Health Organization (WHO), poisoning cases had caused more than 45000 deaths among children and teenagers aged 20 years old and below in year 2004. (myhealth.gov.my)
  • This medicine should not be taken by children aged below 16 years old because it may cause Reye's Syndrome, which is a disease that causes swelling of liver and brain of the children. (myhealth.gov.my)
  • This can cause discolouration of teeth and it can affect children's growth if taken by children aged 12 years old and below. (myhealth.gov.my)
  • This medicine can cause convulsion in children below 2 years old. (myhealth.gov.my)
  • Children younger than 4 years old usually will try to copy his parents' behaviour and may take medicine without being noticed by the parents. (myhealth.gov.my)
  • This medicine should not be used in children younger than 2 years of age. (mayoclinic.org)
  • Children younger than 2 years of age-Use is not recommended. (mayoclinic.org)
  • Children 2 to 5 years of age weighing 13 to 20 kg-1 teaspoonful (1 mg) 3 times a day. (mayoclinic.org)
  • Children up to 6 years of age-Use is not recommended unless directed by your doctor. (mayoclinic.org)
  • Not recommended for children under 12 years. (chemistdirect.co.uk)
  • Tion may fluctuate in dementia with ace- up to 11 times weighing a quantity can be inhibited or not available for use in children under 8 years of age. (stonecottagegardens.com)
  • Do not administer to children under 2 years. (msf.org)
  • In some persons, particularly children under 5 years of age and the elderly, the infection can also cause a complication called hemolytic uremic syndrome, in which the red blood cells are destroyed and the kidneys fail. (cdc.gov)
Exposure1
  • Cases of loperamide abuse reported to the Upstate New York Poison Center and New York City Poison Control Center were analyzed for demographic, exposure, clinical, and laboratory characteristics. (cdc.gov)
Patients7
  • Among the 22 New York loperamide abuse cases identified, 18 patients were male. (cdc.gov)
  • Among the 179 cases, 137 (77%) of the patients were male, the median patient age was 26 years (range = 7-87 years), and 154 (86%) were admitted to or treated in a health care facility. (cdc.gov)
  • Loperamide is also used to decrease the amount of drainage in patients who have ileostomies. (mayoclinic.org)
  • However, elderly patients are more likely to have heart rhythm problems, which may require caution in patients receiving loperamide. (mayoclinic.org)
  • After 2 years, 78 patients remained well, eight had continuing symptoms, and four had died. (wjgnet.com)
  • Healthcare-associated infections (HAIs) are one of the leading causes of morbidity and mortality in the United States and around the world, affecting hundreds of millions of patients each year [ 1 ] In the United States alone, HAIs involve more than 2 million patients annually, resulting in nearly 100,000 deaths and an average cost of 40 billion US dollars [ 2 ]. (hindawi.com)
  • Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer. (mhs.net)
Elderly1
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of loperamide in the elderly. (mayoclinic.org)
Clinical1
  • Their clinical progress was followed over a minimum of 2 years. (wjgnet.com)
Caution1
  • Loperamide should be administered with caution to people with liver failure due to reduced first-pass metabolism. (wikipedia.org)
Abdominal pain2
  • The most frequent symptoms of loperamide overdose are drowsiness, vomiting, and abdominal pain, or burning. (wikipedia.org)
  • A 22-year-old man presented with abdominal pain, passage of blood and mucus per rectum, abdominal distention, fever, and disorientation. (medscape.com)
19951
  • METHODS: The TAM01 study was a phase 3 trial including women with early BC, who had completed 2-3 years of adjuvant tamoxifen between 1986 and 1995. (bvsalud.org)
Frequent1
  • frequent of years mean can which years, for persist symptoms the others, For foods. (chemistdirect.co.uk)
Sweden1
  • Loperamide has been found in drinking water and treated wastewater in Region Stockholm, Sweden, in 2019. (janusinfo.se)
Intestinal1
  • Over the past couple of years, with product introductions, the gastro-intestinal area has grown in sales. (supermarketnews.com)
Abuse2
  • Education of the public and health care providers regarding the dangers of loperamide abuse is an important component of combating opioid addiction in the United States. (cdc.gov)
  • This study aimed to assess the ability of community pharmacists to recognize cases of loperamide abuse at the point of sale, their perspective of and experience toward potential abuse cases. (medworm.com)