• They're not only metastatic castration-resistant, they're 1 step further. (onclive.com)
  • PARP inhibitors work for cancers where no other treatment shows promise, such as metastatic pancreatic cancers and castration-resistant prostate cancer ," he said. (medicalxpress.com)
  • The group agreed that [177Lu]Lu-PSMA should not be administered only after progression to cabazitaxel and that [223Ra]RaCl2 remains a valid therapeutic option in bone-only metastatic castration-resistant PCa. (bvsalud.org)
  • Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer. (cdc.gov)
  • In this cohort study of 962 men with metastatic castration-resistant prostate cancer, mismatch repair deficiency or microsatellite instability-high was significantly more frequent in Black men than White men. (cdc.gov)
  • Alan Turing, the late British mathematician who helped break the Nazi Engima code during World War II and whose work laid the foundation for modern computers, looks set to be given a posthumous pardon by the UK government for an old 'indecency' conviction. (theverge.com)
  • Alan Turing was an outstanding mathematician whose work has had an enormous impact on how we live today," the Bank of England's governor, Mark Carney, said in unveiling the new note. (npr.org)
  • Casodex Information : Casodex (Bicalutamide) is an anti-androgen used in combination with another medication to deal with prostate cancer. (page.tl)
  • what are casodex pills for to suppress castration-resistant prostate most cancers utilizing ASC-J9 via concentrating on androgen receptor in selective prostate cells. (page.tl)
  • Once again, CVD represented the primary cause of mortality overall in this study, with over 500 deaths from this cause compared with a single death from prostate cancer in 5 years of follow-up. (medscape.com)
  • PATIENT SUMMARY: There are situations when dealing with prostate cancer (PCa) where both the doctors who diagnose and track the disease development and response to treatment, and those who give treatments are unsure about what the best course of action is. (bvsalud.org)
  • By the time he died, Turing had been stripped of his security clearance and was forced to undergo a "chemical castration" regime of estrogen shots to avoid serving a two-year prison term. (npr.org)
  • Sima Qian committed suicide rather than undergo castration, which would have made him an outcast in Chinese society. (sonofchina.com)
  • Comparability 1 Non‐steroidal antiandrogen monotherapy versus LHRH agonists or surgical castration monotherapy, Outcome 9 Therapy failure (with imputed event numbers). (page.tl)
  • and, as we learn more and more about the impacts of traditional canine neutering (castration), vasectomy surgery is becoming increasingly popular. (speakingforspot.com)
  • Atwood's work has become increasingly popular among feminists who see in Gilead an accurate reflection of modern day patriarchal society. (altrighttv.com)
  • This treatment works finest in case you've tried hormone therapy and it is not working anymore. (page.tl)
  • U of A oncologist and cell biologist Michael Hendzel (right) was part of a national research team that identified how a new class of cancer drugs known as PARP inhibitors work, opening the door to better targeted therapy for cancer patients. (medicalxpress.com)
  • As the protagonist in my book affirmed after spending 18 years within the ex-gay ministry, these extreme physical, psychological and spiritual attempts do not work. (edgehill.ac.uk)
  • To reveal all of the films referenced would be a spoiler, but The Host echoes such work as "Audition," "Layer Cake," " The Girl with the Dragon Tattoo " and "Chinatown," working as a weird cross between organized crime thriller and psychological horror. (thecriticalcritics.com)
  • They made adjustments, like making sure to create distance between breeding cages as they realized some birds would not copulate because they were intimidated by the proximity of more aggressive males, a condition known as psychological castration. (phys.org)
  • Turing, who was homosexual in an age and place where such orientation was criminalized, was convicted of gross indecency in 1952 and sentenced to chemical castration. (theverge.com)
  • Electronic monitoring of offenders or alteration of criminal tendencies through drugs (e.g., chemical castration) are no longer only the stuff of science fiction novels. (typepad.com)
  • But we're going to be talking about chemical castration, and we have an expert here. (fypeducation.org)
  • In the nonmetastatic, castrate-resistant setting, if you had someone with a BRCA2 , you would imagine that PARP inhibitors would work even better. (onclive.com)
  • Until now it was not understood how the PARP inhibitors work to interfere with cell repair. (medicalxpress.com)
  • Our work explains why PARP inhibitors and radiotherapy are a good combo," said Masson. (medicalxpress.com)
  • Now suffering from a host of medical complications as a result of years of hormone treatment, including phantom pain in his groin and bouts of severe depression, he is five years into his detransition journey and is reintegrating with his anatomically male body. (christianpost.com)
  • Anyone who has ever taken a course in 19th-century American literature has heard that the "obscure hurt" amounted to physical castration or at least severe damage to the genitals and that it accounts both for Henry's failure to fight in the Civil War (as did his younger brothers Wilkie and Bob) and, more tellingly, his lifelong disinterest in marriage. (vqronline.org)
  • For years I'd been getting my bc pills w/a $5 co-pay (they were only about $25 back then, no idea what they are these days). (balloon-juice.com)
  • Freud worked with a five-year-old boy he called "Little Hans" who was brought to Freud by his father. (listverse.com)
  • Two years later, after undergoing injections that made him impotent and grow breasts , he died of cyanide poisoning at age 41 in an apparent suicide. (theverge.com)
  • Now, 190 years after Denkshrift , the assertions made by the professors of Freiburg University are being echoed with renewed vigor. (wordonfire.org)
  • He continued to serve as a court historian, but his castration made him ineligible for higher office. (sonofchina.com)
  • A former editor in chief of Time , which made its name by designating Great Men (and very occasionally Women) "People of the Year," Isaacson specializes in expansive, solidly researched middlebrow histories, the kind that appear under your father's Christmas tree or on a talk-show host's desk. (bookforum.com)
  • We have made a special deal with a well known Professional Research Paper company to offer you up to 15 professional research papers per month for just $29.95. (chuckiii.com)
  • Although I appreciate the pastoral concerns of such an initiative, we must be careful in ensuring that exceptions for such extraordinary circumstances do not muddle the overall theology and beauty of priestly celibacy by reducing it to a mere stipulation that can be inconsequentially revoked en masse . (wordonfire.org)
  • Celibacy, just like marriage, points us towards the real big deal-the marriage of God in Christ with humanity. (preachingtoday.com)
  • You can reject "celibacy" if it doesn't work for you, and look for a better word. (preachingtoday.com)
  • In the years that followed, supporters of his work and gay rights activists have campaigned for him to be pardoned by the government, and in 2012, Liberal Democrat member of the British Parliament Lord Sharkey introduced a bill that would do just that. (theverge.com)
  • Of course, throughout history, similar non-religious based "therapeutic" methods have been tried, among them extreme physical medical procedures: castrations, lobotomies, clitoridectomies and shock treatments. (edgehill.ac.uk)
  • Though written five years ago, the paper remains very timely, especially because it includes a long vignette exploring the use of new technologies for dealing with released sex offenders. (typepad.com)
  • Usually the intruder would argue with her before grabbing her and pouring some of the mind-paralysing oil down the back of her dress, ousting her in exactly the same way that she had dealt with Pines five years before. (mcstories.com)
  • These tribes became the Native Americans of the United States, tribes that over the years became, as Silko says, lazy and complacent and too occupied "with the white man's toys"-television, gambling, alcohol, and drugs. (enotes.com)
  • Then there are "psychiatric" procedures to deal with the mental state of the "sick" gay person, chief among them hypnosis . (edgehill.ac.uk)
  • Saying ten years later he did such and such to me would have not probably done much good either in a court of law to convict him. (tonyskansascity.com)
  • Lepe also advised on investment deals for News Corp, Ministry of Sound and TalkTalk. (wikipedia.org)
  • Almost two years ago to the day, Bruno Dumont's sixth feature, Hors Satan , received its premiere at the Cannes Film Festival. (thequietus.com)
  • His previous effort, Hadewijch , endured a two-and-a-half year wait before playing British screens (a one-off engagement at the London Film Festival notwithstanding), while 2003's Twentynine Palms effectively ended up going straight-to-DVD. (thequietus.com)
  • It's like you posted a page of my notes from the first year of film school. (metafilter.com)
  • Most prominently, the film is deeply indebted to the work of Alfred Hitchcock right from the start. (thecriticalcritics.com)
  • There's also a great deal of homoeroticism in the film, and not so buried that it needs to be considered subtext. (ruthlessreviews.com)
  • I remember a short film from years ago called Ray's Male Heterosexual Dance Hall , that placed corporate suits in a room where they danced with each other while talking shop, offering favors, and cutting deals. (ruthlessreviews.com)
  • The various UK arthouse labels are hardly falling over themselves to pick up his work (to date, the spoils have been shared between four of them) and even when they do it rarely guarantees an immediate release. (thequietus.com)
  • This is perhaps a prelude to things that you will hear them say as we get closer to March this year, which is the government shut down date. (rushlimbaugh.com)
  • The research is the result of a 20-year collaboration between Hendzel's research lab and those of Guy Poirier at Laval University's Centre de recherche sur le cancer and Jean-Yves Masson of the CHU de Québec's research centre. (medicalxpress.com)
  • Both breeding centers report a record year for new chicks, about 40 each. (phys.org)
  • The ongoing culture war over the treatment of women has flared up in recent years. (altrighttv.com)
  • The novel covers five hundred years of history and incorporates dozens of themes, motifs, ideas, cultures, ideologies, and discourses into a vast mural of revisionist history, told from the viewpoint of the world's marginalized groups-from the indigenous peoples to the handicapped. (enotes.com)
  • His work was the first comprehensive history of China, and it included accounts of myths and legends that were significant to the ancient Chinese. (sonofchina.com)
  • His legacy lives on, and his works continue to serve as a go-to resource for learning about China's past and present culture and history. (sonofchina.com)
  • What we've done is identify how the drugs work," said University of Alberta oncologist and cell biologist Michael Hendzel. (medicalxpress.com)
  • Starting from the clinical experience in psychoanalysis research, this article deals with the concept of anguish in the Freudian plot. (bvsalud.org)
  • If they cut your dicks off, it's no big deal," she told male students. (altrighttv.com)
  • In the last year, the escalation of insecurity has grown as livestock thefts have advanced into the peri-urban and then urban areas of the region, leading to an increasing loss of lives and property in these areas. (lse.ac.uk)
  • We started on multi-flora rose last year along with thistle. (kevinsthoughts.com)
  • Also started on shingle oak sprouts using something called PastureGuard last year. (kevinsthoughts.com)
  • Prior posts exploring how a Justice Roberts might impact the Supreme Court's work in the death penalty arena are assembled here , and some of my previous kvetching about the Supreme Court's expenditure of so much time and energy on death penalty cases can be found here and here and here and here and here . (typepad.com)
  • In addition, he spent a great deal of time travelling throughout China in search of material for his historical works. (sonofchina.com)
  • And you'll understand why, 15 years after his death, there's renewed interest from Hollywood in Burroughs and the Beat movement he personified. (advocate.com)
  • Evidence from doctors strikes in LA and Isarael and Columbia - death rate dropped from 18 - 50% when doctors stopped working. (bitsofbooks.com)
  • Shortly before his death in 86 BCE, he finished the Records of the Grand Historian, leaving behind a work that would serve as an inspiration to future historians and academics. (sonofchina.com)
  • indeed, CVD has been the leading cause of death in the US every single year since 1919. (medscape.com)
  • Castration was part of the punishment for Sima Qian, a brutal act that would have left him an outcast in Chinese society. (sonofchina.com)
  • Nevertheless, Sima Qian showed remarkable fortitude and commitment to his work by opting to take the punishment rather than compromise his integrity. (sonofchina.com)
  • Public castration would to me have been a fitting punishment for the crime he committed. (tonyskansascity.com)
  • In recent years, other updates to the Bank of England's currency have featured Jane Austen on the 10-pound note and Winston Churchill on the 5-pound. (npr.org)
  • reactions to casodex has been used as monotherapy for greater than twenty years, however no dose‐finding research towards a at the moment accepted endpoint (e.g. (page.tl)
  • Many dioceses were suffering priest shortages and some were even dealing with issues of sexual misconduct among the clergy. (wordonfire.org)
  • The loudest protestations most often come from those who refuse to watch films at all, quick to judge and condemn the works as teeming with misogyny and even glorifying sexual violence against women. (rue-morgue.com)
  • A sweet and inspiring story about art, love, and gardening, Into the Garden With Charles is set against around the author's noteworthy garden outside his 300-year-old house in the hamlet of Orient on Long Island. (advocate.com)
  • He had invited a 19-year-old drifter named Arnold Murray to his house and they had had consensual sex. (dictionary.com)
  • It would begin with her working up in the admin centre that was perched atop the hive, it was a normal session and her drones would be all around her, busy with the plethora of tasks needed to keep the hive functioning. (mcstories.com)
  • I got a note here from a friend listening intently to the program, all this that we've discussed today, and this is really good: 'The Only Hope the Country Has - The only hope this country has is through the innovations of a free people, a people who are free to benefit from their good ideas and their hard work. (rushlimbaugh.com)
  • Hard work born of free people benefiting from their innovations. (rushlimbaugh.com)
  • It invariably springs from the work of the legislator who first established the values of a people. (counter-currents.com)
  • In all these years of pedagogical work I have never heard any complaints from students or their parents. (altrighttv.com)
  • You have to DO MORE- therefore you will go to purgatory when you die - and the good works of your remaining friends and relatives, who buy candles, holds masses for you, pay money to the church, attend each service and pray to Mary - well thats how you get to heaven. (tonyskansascity.com)
  • [ 11 ] It was terminated approximately 7 years early because of a lack of efficacy, and even a potential negative impact with these supplements at the dosages used. (medscape.com)
  • Kaestel, then a drifter with a criminal record, was 29 years old. (dictionary.com)
  • His appointment followed the merger in March 2019 of Lepe Partners, the merchant bank he co-founded in 2011, with Alvarium which works across North America, Europe and Asia Pacific, supervising $15bn+ of assets. (wikipedia.org)
  • After graduating from the University of Nottingham, Goodwin worked briefly at Coopers and Lybrand, where for one assignment he was asked to compile two reports. (wikipedia.org)
  • Ironic twist - many of the best and brightest women get MBA so they can get a well-paid job, but they end up marrying the best and brightest men, who also earn high wages - which gives these women the luxury of not having to work. (bitsofbooks.com)
  • LongAcre worked with Elisabeth Murdoch, helping to build her TV production business Shine via a series of acquisitions. (wikipedia.org)