Years receptors adrenergic alpha 2. Medical search. Frequent questions

Adrenergic alpha-2 Receptor Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Adrenergic alpha-2 Receptor Agonists" by people in this website by year, and whether "Adrenergic alpha-2 Receptor Agonists" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Adrenergic alpha-2 Receptor Agonists" by people in Profiles. (rush.edu)
These agents compete with beta-adrenergic agonists for available beta-receptor sites. (medscape.com)
The high potency of Ro 25-1553 extends to studies on isolated, histamine-contracted, human bronchial smooth muscle, where Ro 25-1553 exhibits a 390-fold enhancement over native VIP and is more potent than other bronchodilating drugs, such as the beta 2-adrenoceptor agonists isoproterenol and salbutamol. (aspetjournals.org)
Cooling augmented contractions evoked by the alpha 2-adrenergic agonists B-HT 920 and UK 14304 but did not affect responses to the full alpha 1-adrenergic agonist phenylephrine. (johnshopkins.edu)
Therefore, cooling reduces alpha 1-adrenergic responsiveness in canine cutaneous veins, but in the case of full alpha 1-adrenergic agonists such as norepinephrine and phenylephrine the inhibitory effect of cooling is buffered by an alpha 1-adrenoceptor reserve. (johnshopkins.edu)
The active ingredient in Alphagan Eye Drops is brimonidine tartrate which belongs to a group of medicines called alpha-2 adrenergic receptor agonists and works by reducing pressure within the eyeball. (rchs69.org)
2-adrenergic agonists (e.g. clonidine) or with somatostatin. (druglibrary.org)
Caffeine finds its way into Alphamine for its specific synergy with the beta-agonists through its ability to inhibit phosphodiesterase activity and interact with the adenosine receptor. (helpyougetgains.com)
These include the alpha-2 adrenergic agonists clonidine and guanfacine, the nonselective beta-adrenergic agent propranolol, and most promising prazosin, which is an alpha-1 adrenergic receptor antagonist that blocks the actions of NE on alpha-1 receptors(Petrakis, 2016). (duepapers.net)
Guanfacine is in a class of medications called centrally acting alpha 2A -adrenergic receptor agonists. (medlineplus.gov)
There is strong evidence that obesity leads to increased sympathetic modulation and a decreased vagal tone leading to a lack of autonomic control (characterized by reduction of heart rate variability) that can bring about changes in the renin-angiotensin-aldosterone system in alpha agonists and central alpha 2-1 and beta-adrenergic receptors. (bvsalud.org)

Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. (aspetjournals.org)
Doxazosin mesylate is a quinazoline compound that is a selective alpha1-adrenergic antagonist. (medscape.com)
Alpha-receptor antagonist medications potentially interfere with iris muscle dilation, resulting in difficult lens removal and possibly increasing complications. (urotoday.com)
alpha 2-adrenergic receptors irreversible antagonist. (inrae.fr)
This study was designed to investigate the effects of clonidine and yohimbine, an alpha-2 ( α 2 ) adrenoceptor agonist and antagonist respectively in the tail flick and hot plate tests. (biomedcentral.com)
The aim of the experiment was to study the role of the noradrenergic receptor system in the NMRs using the receptor agonist clonidine and antagonist yohimbine in the tail flick and hot plate tests, in order to establish whether NMR can be used as animal model for noradrenergic mechanisms in thermal antinociception. (biomedcentral.com)
All effects were antagonized by the alpha 1-adrenoceptor antagonist prazosin (0.1 microM), indicating receptor-mediated effects. (aspetjournals.org)

However, the contractions evoked by the partial alpha 1-adrenergic agonist St 587 were virtually abolished by cooling. (johnshopkins.edu)
It is a beta-2 (beta 2) agonist prescribed overseas as a bronchodilator, but not approved for use in this country. (kimiamahvand.ir)
It has a role as a bronchodilator agent, a beta-adrenergic agonist and a sympathomimetic agent. (kimiamahvand.ir)
https://fitunit.net/clenbuterol-fotos-clenbuterol-efecto-mujeres/ Clenbuterol is a chemical called a beta-2-adrenergic agonist. (kimiamahvand.ir)
Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996. (globalstaffingprofessionals.com)
Agmatine acts as an agonist at imidazoline and alpha-2-adrenergic receptors, also modulating NMDA receptor activity. (psicothema.com)
Dexmedetomidine, an alpha 2 agonist, has been used to manage symptoms of delirium in pediatric patients and is gaining popularity in treatment for pediatric patients with severe anticholinergic toxidrome [ 5 , 6 ]. (hindawi.com)
OBJECTIVES: We aimed to assess whether clonidine, an α2-adrenergic receptor agonist, would improve ICDs. (bvsalud.org)

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. (wikipedia.org)
Molecular cloning and ligand binding studies have shown the alpha 2 class of adrenergic receptor (alpha 2-AR) to be a family of at least three related subtypes in humans. (aspetjournals.org)
To begin this process, we have isolated two mouse genomic clones encoding alpha 2-AR subtypes and expressed these genes in COS-7 cells for binding studies. (aspetjournals.org)
In turn, appropriate structural modifications performed on the structure of methoctramine led to the discovery of new polyamines endowed with high affinity and selectivity for (a). muscarinic receptor subtypes, (b). (inrae.fr)
This group also found that while both receptor subtypes were seen in the membranes and cytoplasm of cell bodies, the β 2 receptor subtype, but not the β 1 , was localized to the nucleus. (frontiersin.org)

It inhibits postsynaptic alpha-adrenergic receptors, resulting in the vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure. (medscape.com)
This drug, the first of a new class of antihypertensive agents, interferes with alpha-adrenergic function at the postsynaptic level. (erowid.org)
Blocks postsynaptic mesolimbic dopaminergic receptors in brain and reduces stimuli to brainstem reticular system. (medscape.com)
May relieve nausea and vomiting by blocking postsynaptic mesolimbic dopamine receptors, through anticholinergic effects, and by depressing reticular activating system. (medscape.com)
By preventing reuptake of 5-HT presynaptically, SSRIs result in more 5-HT to stimulate postsynaptic 5-HT receptors. (msdmanuals.com)

The other clone (M alpha 2-10H) closely resembles the human alpha 2-C10 subtype in sequence but binds with significantly lower affinity to yohimbine and rauwolscine, members of a distinct class of bulky alpha 2-selective antagonists commonly used to evaluate alpha 2-AR function in vivo. (aspetjournals.org)
This level of risk was subsequently confirmed and was thereafter described with all currently used alpha-1 adrenergic receptor antagonists [3,4,5,6]. (urotoday.com)
The FDA considers the risk for IFIS to be a class effect for alpha-1 adrenergic receptor antagonists [8,9]. (urotoday.com)
Pausinystalia alkaloids are known as "Selective Alpha-2 adrenergic antagonists" within the body. (helpyougetgains.com)

Thus, polyamines tripitramine (9) and spirotramine (33), among others, were designed, which were shown to be highly selective for muscarinic M(2) and M(1) receptors, respectively. (inrae.fr)
SSRIs are selective to the 5-HT system but not specific for the different 5-HT receptors. (msdmanuals.com)

The affinity of dexmedetomidine is eight times greater than clonidine affinity for the α2 receptors. (bvsalud.org)
En pratique clinique, l'intensiviste dispose de deux α2-agonistes, à savoir la clonidine et la dexmédétomidine. (bvsalud.org)
The second class of non-stimulants are alpha adrenergic agents, such as guanfacine (Intuniv) and clonidine (Kapvay). (madinamerica.com)

It may be used to treat excessive beta-receptor stimulation in patients with inoperable metastatic pheochromocytoma. (medscape.com)
Existence and alpha 1-adrenergic stimulation of inositol polyphosphates in mammalian heart. (aspetjournals.org)
1,4,5-IP3 (significant at 10 microM) and both IP4 isomers (significant at 1 microM) increased after alpha-adrenoceptor stimulation, whereas 1,3,4,5,6-IP5 and IP6 remained unaffected. (aspetjournals.org)
Increased inositol polyphosphate turnover may be involved in the mechanism(s) whereby alpha 1-adrenoceptor stimulation produces an increase in myocardial force of contraction. (aspetjournals.org)

In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)

Its drug action is transient and alpha-adrenergic blockade incomplete. (medscape.com)
Prazosin is thought to produce alpha-adrenergic blockade in a different way from the classical alpha-blockers phenoxybenzamine and phentolamine.2 The unusual side effects of prazosin, frequency of micturition and incontinence of urine, have been attributed to this alpha-blocking action.5 We now consider priapism a potential hazard of treatment with prazosin. (erowid.org)
Cooling (from 37 to 24 degrees C) augmented contractions to norepinephrine under control conditions and after alpha 1-adrenergic blockade (prazosin) but not following alpha 2-adrenergic blockade (rauwolscine). (johnshopkins.edu)
Moreover, following partial irreversible blockade of the alpha 1-adrenoceptors with phenoxybenzamine, cooling also reduced the contractions evoked by phenylephrine. (johnshopkins.edu)

The concept that polyamines may represent a universal template in the receptor recognition process is embodied in the design of ligands for different biological targets. (inrae.fr)
Finally, the universal template approach formed the basis for modifying benextramine (1) structure to the design of ligands, which display affinity for acetylcholinesterase and muscarinic M(2) receptors. (inrae.fr)

structure to achieve specific recognition of muscarinic receptors that led to the discovery of methoctramine (2). (inrae.fr)

These studies have not, however, identified distinct subtype-specific functions for these receptors in vivo. (aspetjournals.org)
It should be possible to extend the analysis of alpha 2-AR subtype function to the animal level through the use of experimental mammalian embryology in mice. (aspetjournals.org)
Sequence homology and ligand binding data allow the assignment of one clone (M alpha 2-4H) as the mouse homolog of the human alpha 2-C4 subtype. (aspetjournals.org)
Pretreatment with chlorethylclonidine, which selectively alkylates the alpha-1B subtype, did not affect the Emax value of phenylephrine-induced contractions, but significantly shifted the curve to the right. (aspetjournals.org)

At low doses, alpha-adrenergic receptor blockers may be used as monotherapy in the treatment of hypertension. (medscape.com)
As a result, concurrent diuretic therapy may be required to maintain the hypotensive effects of alpha-receptor blockers. (medscape.com)
The "intra-operative floppy iris syndrome" cataract surgery complication has been reported in men using alpha-blockers. (urotoday.com)
The risk of complicated cataract surgery was 14.9% in patients using alpha-blockers, approximately 50% higher than those not receiving this medication (9.5%) (p=0.003). (urotoday.com)
BackgroundIn men with chronic prostatitis-chronic pelvic pain syndrome, treatment with alpha-adrenergic receptor blockers early in the course of the disorder has been reported to be effective in some, but not all, relatively small randomized trials.MethodsWe conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of alfuzosin, an alpha-adrenergic receptor blocker, in reducing symptoms in men with chronic prostatitis-chronic pelvic pain syndrome. (ox.ac.uk)
Four drug classes were evaluated in the trials: thiazides (21 trials), beta-adrenergic blockers (5), calcium-channel blockers (4) and angiotensin-converting-enzyme (ACE) inhibitors (1). (cmaj.ca)

By binding to specific receptor sites, these agents appear to potentiate the effects of GABA and facilitate inhibitory GABA neurotransmission and other inhibitory transmitters. (medscape.com)

Analysis of these receptors identified a conservative Cys201 to Ser201 change in the fifth transmembrane domain of M alpha 2-10H as being responsible for the low affinity of the mouse receptor for yohimbine. (aspetjournals.org)
As a matter of fact, the insertion of different pharmacophores onto the polymethylene tetraamine backbone can tune both affinity and selectivity for any given receptor. (inrae.fr)

Bhalla AK, Hoffbrand BI, Phatak PS, Reuben SR. "Prazosin and priapism" Br Med J . 1979 Oct 24;2(6197):1039. (erowid.org)
Several randomized controlled trials have found that the alpha-1 blocker prazosin is effective in reducing symptoms of posttraumatic stress disorder (PTSD) among active-duty soldiers(Roundup, 2017). (duepapers.net)

Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)
which is widely used as a pharmacological tool for muscarinic receptor characterization. (inrae.fr)

It is an alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension that results from catecholamine effects on alpha receptors. (medscape.com)
Alpha adrenergic agents mimic epinephrine and norepinephrine and stimulate the same receptors as these neurotransmitters. (madinamerica.com)
Stimulates release of epinephrine stores, producing alpha- and beta-adrenergic receptors. (medscape.com)
Although most respondents reported being likely to choose local anesthetics at less toxic concentrations (including 2% mepivacaine or lidocaine), they were also likely to have similar vasoconstrictor solutions (epinephrine) as the second choice. (bvsalud.org)

These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. (wikipedia.org)
Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)

There were no significant changes in SERCA2a expression in the isoproterenol group, although 2 of 5 hearts expressed only 50% of the mean control level Studies have found that it can protect neurons from oxidative stress and inflammation, both of which are believed to contribute to the degeneration of dopamine-producing cells in PD, clenbuterol leginfo. (kimiamahvand.ir)
To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)

This is a nonselective alpha-adrenergic blocking agent. (medscape.com)
This is a nonselective beta-adrenergic receptor blocker. (medscape.com)

2016 Jul 2;11(7):482-8. (lu.se)

It may take 2 weeks before you feel the full benefit of guanfacine extended-release tablets. (medlineplus.gov)

After primary treatment with an alpha-receptor blocker, propranolol hydrochloride may be used as adjunctive therapy if control of tachycardia becomes necessary before or during surgery. (medscape.com)
Case 1- A 43-year-old West Indian was found to be hypertensive in 1976 and treated initially with propranolol 160 mg and hydrallazine 25 mg both thrice daily. (erowid.org)

In comparative clinical studies with timolol 0.5%, lasting up to one year, the IOP lowering effect of Brimonidine Tartrate Ophthalmic Solution was approximately 4-6 mm Hg compared with approximately 6 mm Hg for timolol. (globalstaffingprofessionals.com)
The safety and effectiveness of Brimonidine Tartrate Ophthalmic Solution have not been studied in pediatric patients below the age of 2 years. (globalstaffingprofessionals.com)
Each 1 mL contains brimonidine tartrate 2 mg. (medbroadcast.com)

These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)

The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it. (wikipedia.org)

Alpha adrenergic receptors are blocked by TCAs in the periphery, causing vasodilation. (emra.org)

Of adults 50 to 80 years old, 29% of men in Europe and 34% of men in the United States have moderate to severe lower urinary tract symptoms. (urotoday.com)
Alpha-blocker medications are the first line of therapy for men with these urinary symptoms. (urotoday.com)
A study published in 2005 described a new clinical entity, the "intra-operative floppy iris syndrome" (IFIS), and suggested that this syndrome was associated with tamsulosin, a drug used widely for the treatment of lower urinary tract symptoms (LUTS) due to benign prostate enlargement [2]. (urotoday.com)
The rates of adverse events in the two groups were also similar.ConclusionsOur findings do not support the use of alfuzosin to reduce the symptoms of chronic prostatitis-chronic pelvic pain syndrome in men who have not received prior treatment with an alpha-blocker. (ox.ac.uk)

Since the tail-flick and hot plate tests mediate the effects at spinal and supraspinal levels respectively, the present study indicates the presence and involvement of noradrenergic receptors in thermal antinociception at spinal and supraspinal levels of the NMR, similar to what has been found in other mammals. (biomedcentral.com)
However, evidence is now accumulating for rapid corticosteroid actions 25 , 26 , and the existence of membrane-bound steroid receptors that may mediate these rapid actions 27 , 28 . (ersjournals.com)

2000 Feb;26(2):256. (umaryland.edu)

Nanoparticle inhalation modulates arteriolar sympathetic constriction: role of nitric oxide, prostanoids, and alpha-adrenergic receptors. (cdc.gov)

The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)

T3 binds to the nuclear receptor (TR) and combines with another receptor (RXR) then combines with a receptor element on DNA. (cdc.gov)

The main mechanism of action proposed for local anesthetics (LAs) is related to the binding of these substances to sodium channels receptors (Na+), leading to the reduction or elimination of the permeability of these ions and interruption of the nervous conduction 3-4 . (bvsalud.org)

1999 Sep 11;841(1-2):70-7. (nih.gov)

To date, a number of adrenergic agents have been tested for their efficacy in treating PTSD. (duepapers.net)
The use of Amiloride in children under 18 years of age is not recommended as safety and efficacy have not been established. (janusinfo.se)

1) Tetrahydrozoline HCL: The only active ingredient in these eye drops, tetrahydrozoline HCL reduces redness by binding to and activating alpha-adrenergic receptors in the eyes, which play an important role in the regulation of blood pressure. (penzionkrusetnica.sk)
Tell your doctor about the allergy and This item Visine-A Multi-Action Eye Allergy Relief Eye Drops, 0.5 ounce each, Twin Pack Bausch + Lomb Opcon-A Allergy Relief Eye Drops, 0.5 Ounces/15 mL (Pack of 2) Packaging May Vary Visine Totality All-In-One Multi-Symptom Relief Lubricating, Astringent & Redness Reliever Eye Drops for Irritated, Burning, Gritty, Itchy, Red Eyes, 0.5 fl. (penzionkrusetnica.sk)
Or in less science-y terms, tetrahydrozoline HCL causes the superficial blood vessels in our eyes to constrict, which reduces blood flow, which in turn momentarily reduces redness and inflammation. (penzionkrusetnica.sk)

Thanks to the American Rescue Plan, today the U. We strive to set the standard for quality, safety and immunogenicity down to 5 years of age, have been reported in patients with COVID-19 pneumonia who were not on ventilation But the scientists of Afghanistan in Kabul from 2017 through 2019, women having a remote, compact device. (rchs69.org)
While Visine has been on the market for years, Lumify was just recently approved by the FDA in December of 2017. (penzionkrusetnica.sk)
While many civilians do not seek help, or wait years to do so, concerns about stigma may be amplified among veterans because military culture places a high value on emotional strength and mental toughness(Meshberg-Cohen, 2017). (duepapers.net)
J Vasc Res (2017) 54 (2): 92-99. (karger.com)

They stimulate 5-HT 1 receptors, with antidepressant and anxiolytic effects, but they also stimulate 5-HT 2 receptors, commonly causing anxiety, insomnia, and sexual dysfunction, and 5-HT 3 receptors, commonly causing nausea and headache. (msdmanuals.com)

To our knowledge, the involvement of the noradrenergic receptor system in antinociception against thermal stimuli has not been previously studied in the NMR. (biomedcentral.com)

If possible, alpha blocker medications should be discontinued prior to eye surgery in older patients. (urotoday.com)
As alpha-blocker medications are the first line of therapy for men with LUTS, these reports of IFIS led the Food and Drug Administration, American Urological Association, American Academy of Ophthalmology, and American Society of Cataract and Refractive Surgery to issue statements alerting physicians and patients to potential difficulties during cataract surgery in patients using alpha-1 blocker therapy [7,8,9]. (urotoday.com)

The following literature sources were searched: MEDLINE (1966-1997), the Cochrane Library (1998 CD-ROM, issue 2) and references from previous meta-analyses published from 1980 to 1997. (cmaj.ca)

2023;49(2):e12891. (lu.se)
270(2): 864-876 (2023) doi:10.1007/s00415-022-11418-y. (lu.se)

iScience 2022 Jan 19;25(2):103771. (lu.se)

It is metabolized so one iodine atom is removed to produce T3 - about 10 times as active as T4 in binding to a receptor that exerts the action as receptor to the thyroid hormone. (cdc.gov)
The iodine hormone exerts its action on receptors on the nucleus in cells. (cdc.gov)

Metabolic syndrome (MetS) is a cluster of metabolic risk factors for cardiovascular disease and type 2 diabetes. (bvsalud.org)
There are increased risk for: Atherosclerosis, Peripheral vascular disease, Coronary heart disease, Heart attack, Stroke and Type 2 diabetes. (bvsalud.org)
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. (lu.se)

2. Lindvall, O., Björklund, A.: The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. (lu.se)

Preoperatively, prepare patients with pheochromocytomas by treating them with an alpha-blocker or a tyrosine hydroxylase inhibitor, such as metyrosine, for 1-2 weeks, after which administration of a beta-blocker can be considered. (medscape.com)

Cooling and alpha 1- and alpha 2-adrenergic responses in cutaneous veins: role of receptor reserve. (johnshopkins.edu)
Experiments were designed to determine the effects of cooling on alpha 1- and alpha 2-adrenergic responses in isolated canine cutaneous veins. (johnshopkins.edu)

Brimonidine has a rapid onset of action, with peak ocular hypotensive effect seen at 2 hours post-dosing. (globalstaffingprofessionals.com)

Due to these unique characteristics, researchers have been bio prospecting NMRs as research animal models for nociception with the aim to further understand mechanisms involved in various biological diseases affecting humans [ 2 , 3 , 5 ]. (biomedcentral.com)
When these receptors are "on" they are activating fat storing mechanisms. (helpyougetgains.com)

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)

Only 2 reviews have attempted to distinguish between the effectiveness of antihypertensive therapies used as first-line agents. (cmaj.ca)

receptors may cause respiratory depression and other undesired effects (e.g. nausea, vomiting, pruritus). (druglibrary.org)

It is also associated with insulin resistance (glucose intolerance) and obesity or overweight 1,2 . (bvsalud.org)

This kind of drugs are traditional in most Eastern or investment of capital, human resources, and various technology African countries and have been used for hundreds of years or expertise. (med-abstracts.com)
v) analysis of 68 approved drugs, it takes an average of 10 to 15 years currently, most researchers also regard those on-patent drugs as old and US$ 800 million to bring a single drug from bench to patient's drug resources because of its established safety evaluation and po- bedside [1]. (med-abstracts.com)
Actually some old drugs have been developed for new indications, such as aspirin for Arsenic trioxide has been used for the treatment of cancers and stroke, sildenafil (Viagra) for erection dysfunction and other disorders for more than 500 years in China [14]. (med-abstracts.com)

The signal transmitted by the brain is routed through 2 intermediate segments (the brainstem and the sacral spinal cord) prior to reaching the bladder. (medscape.com)

Agonists13

Antagonist7

Agonist8

Subtypes5

Postsynaptic5

Antagonists4

Selective2

Clonidine3

Stimulation4

Alpha1-adrenergic1

Blockade4

Ligands2

Muscarinic receptors1

Subtype4

Blockers6

Inhibitory1

Affinity2

Prazosin2

Characterization2

Epinephrine4

Neurotransmitter2

Dopamine2

Nonselective2

20161

Guanfacine1

Propranolol2

Brimonidine Tartrate3

Cholinergic1

Adrenoceptor1

Vasodilation1

Symptoms4

Mediate2

20001

Sympathetic1

Pharmacological1

Binds1

Sodium1

19991

Efficacy2

Redness3

20174

Stimulate1

Noradrenergic1

Medications2

REFERENCES1

20232

20221

Exerts2

Type 2 diabet3

Catecholamine1

Inhibitor1

Veins2

Hypotensive1

Mechanisms2

Compounds1

Agents1

Nausea1

Insulin1

Drugs3

Spinal1