• adhesion
  • These results show that PKC participates in a novel signaling pathway that modulates desmosomal adhesion in response to wounding. (soton.ac.uk)
  • Knockdown of AF6i3 in epithelial cells, which express only this isoform, resulted in impaired E-cadherin-dependent intercellular adhesion due to concomitantly reduced association of E-cadherin with F-actin and p120-catenin. (biologists.org)
  • Therefore, we propose that the AF6i3 protein stabilizes E-cadherin-dependent adhesion during dynamic processes, such as wound closure and formation of cell junctions, by linking the E-cadherin-catenin complex to the actin cytoskeleton via its F-actin-binding site. (biologists.org)
  • Haptotaxis (from Greek ἅπτω (hapto, "touch, fasten") and τάξις (taxis, "arrangement, order")) is the directional motility or outgrowth of cells, e.g. in the case of axonal outgrowth, usually up a gradient of cellular adhesion sites or substrate-bound chemoattractants (the gradient of the chemoattractant being expressed or bound on a surface, in contrast to the classical model of chemotaxis, in which the gradient develops in a soluble fluid. (wikipedia.org)
  • tissue
  • These cells then trigger the muscle, nerve, and connective-tissue cells below to dedifferentiate (essentially, lose the specialized characteristics that make them a neuron or muscle cell), divide, and form a ball of stem-cell-like cells. (technologyreview.com)
  • Strategies include the rearrangement of pre-existing tissue, the use of adult somatic stem cells and the dedifferentiation and/or transdifferentiation of cells, and more than one mode can operate in different tissues of the same animal. (wikipedia.org)
  • Scarring takes place in response to damaged or missing tissue following injury due to biological processes or wounding, it is a process that occurs in order to replace the lost tissue. (wikipedia.org)
  • Wound healing itself is a particularly complex process and the mechanisms by which scarring occurs involves inflammation, fibroplasia, the formation of granulation tissue and finally scar maturation. (wikipedia.org)
  • Clara was an active member of the Nazi Party and used tissue taken from executed victims of the Third Reich for his research-including the work that led to his discovery of Clara cells. (wikipedia.org)
  • Mechanical effects like the buildup of tensile forces may play an important role for both division as well as motility of cells in tissue. (wikipedia.org)
  • The ability of the skin to heal even after considerable damage has occurred is due to the presence of stem cells in the dermis and cells in the stratum basale of the epidermis, all of which can generate new tissue. (wikipedia.org)
  • Tissues obtained from amniotic cell lines show promise for patients suffering from congenital diseases or malformations of the heart, liver, lungs, kidneys, and cerebral tissue. (wikipedia.org)
  • This makes the possibility of rejection of the cells by the recipient tissue less likely. (wikipedia.org)
  • Unlike traditional tissue transplants, where the donor and recipient have to be in complete sync as far as blood type and overall compatibility and even still can show tissue rejection, amniotic epithelial cells can be used and show a higher likelihood of tissue acceptance. (wikipedia.org)
  • Unlike embryonic stem cells, amniotic stem cells have not shown a propensity for developing into teratomas and other cancer-like tumors upon injection into living tissue. (wikipedia.org)
  • To overcome that stage and jump-start the healing process a number of factors need to be addressed such as bacterial burden, necrotic tissue, and moisture balance of the whole wound. (wikipedia.org)
  • for example, cancerous tissue can grow until blood cannot reach the cells and the tissue becomes an ulcer. (wikipedia.org)
  • It is the process by which the cells in the body regenerate and repair to reduce the size of a damaged or necrotic area and replace it with new living tissue. (wikipedia.org)
  • During the maturation phase of wound healing, unnecessary vessels formed in granulation tissue are removed by apoptosis, and type III collagen is largely replaced by type I. Collagen which was originally disorganized is cross-linked and aligned along tension lines. (wikipedia.org)
  • fetal wound
  • As a result of the influence of fetal wound healing, recent trends in wound dressing have been toward a focus on the wet condition. (springer.com)
  • Since the observation of scar free healing was first reported in the early fetus more than three decades ago, research has focused intently on the underlying mechanisms which separate scarless fetal wound repair from normal adult wound healing. (wikipedia.org)
  • collagen
  • Receptor activation happens when collagen binds into preformed DDR dimers on cell membrane, when collagen is bound, a conformational change probably occurs, which causes cytosolic kinases to rotate to face each other, and their autophospohorylation. (wikipedia.org)
  • Cells also need a collagen framework along which to grow. (wikipedia.org)
  • Since ischaemia and most toxins do not destroy collagen, it will continue to exist even when the cells around it are dead. (wikipedia.org)
  • proteome
  • After plasma treatment, neglected and treated cell civilizations had been incubated for many time periods allowing evaluation of wound curing and proteome analyses (incubation for Gimeracil manufacture 24?h, 48?h, and 72?h just before cell harvesting). (healthweeks.com)
  • fibrosis
  • Idiopathic pulmonary fibrosis (IPF) is a disease marked by fibrosis in lung mesothelial cells. (wikipedia.org)
  • The result is that there becomes an aggregation of myofibroblasts in the lungs, which leads to fibrosis of the mesothelial cells. (wikipedia.org)
  • Such factors include chronic fibrosis, edema, sickle cell disease, and peripheral artery disease such as by atherosclerosis. (wikipedia.org)
  • vesicles
  • The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by α-secretase, or internalized within clathrin-coated vesicles. (bu.edu)
  • disruption
  • For disruption, cells Gimeracil manufacture had been primarily shock-frozen in water nitrogen and defrosted inside a thermomixer (Eppendorf, Hamburg, Germany) at 1400?rpm in 30C for ten minutes. (healthweeks.com)
  • electromagnetic energy
  • A method of and apparatus for the treatment of chronic wounds using pulsed electromagnetic energy provides a constant, known and replicable dosage output which remains unaffected by the capacitance of the patient's body. (google.com)
  • Regulation
  • These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. (wikipedia.org)
  • occurs
  • Rapid transition from calcium independence to calcium dependence also occurs when cells are treated with phorbol esters that activate PKC. (soton.ac.uk)
  • ATN occurs when the epithelial cells that line the kidney are destroyed by either a lack of oxygen (such as in hypovolemic shock, when blood supply to the kidneys is dramatically reduced), or by toxins (such as some antibiotics, heavy metals or carbon tetrachloride). (wikipedia.org)
  • kidney
  • Renal cell carcinoma (RCC) is the most common cancer in adult kidney. (bu.edu)
  • Cabozantinib was approved in November 2012 for the treatment of medullary thyroid cancer and it has also started clinical trials for the treatment of prostate, bladder, ovarian, brain, melanoma, breast, non-small cell lung, pancreatic, hepatocellular and kidney cancers. (wikipedia.org)
  • regulates
  • Using this technique, we show that actomyosin constriction negatively regulates cell mobilisation and that the advancement of cell sheets and the mobilisation of rows of cells behind their leading edges are independently regulated. (biologists.org)
  • tumor
  • Another component important in the haptotaxis of tumor cells is MenaINV, which is an actin regulatory protein that becomes increasingly expressed in tumor cells. (wikipedia.org)
  • This actin regulatory protein binds to fibronectin receptors and aids in the haptotactic and chemotactic processes of tumor cells. (wikipedia.org)
  • This ability is not limited to tumor cells. (wikipedia.org)
  • Amniotic epithelial cells have not been known to produce cancerous tumors in the host despite the fact that these cells do express genes found in embryonic stem cells that are known to promote tumor formation. (wikipedia.org)
  • mechanism
  • We have designed a simpler method, which uses ImageJ and a time-lapse series of phase-contrast images, to analyse the mechanism underpinning collective cell mobilisation. (biologists.org)
  • repair
  • This cell-based system not only allows us to dissect the detailed mechanisms that regulate RPE repair under different conditions, but may also provide a platform to understand the lack of repair in diseased RPE. (arvojournals.org)
  • Repair of large cutaneous wounds, greater than 2 or 3 cm across, requires skin grafting because of the inefficiency of long-distance re-epithelialisation ( Singer and Dagum, 2009 ). (biologists.org)
  • PAI-1) involved in wound repair. (biologists.org)
  • and wound repair (1999). (wikipedia.org)
  • epithelium
  • Club cells are found in the ciliated simple epithelium. (wikipedia.org)
  • One of the main functions of club cells is to protect the bronchiolar epithelium. (wikipedia.org)
  • Club cells also act as a stem cell, multiplying and differentiating into ciliated cells to regenerate the bronchiolar epithelium. (wikipedia.org)
  • The narrow channels are usually less than 2 mm in diameter and they are lined by a simple cuboidal epithelium, consisting of ciliated cells and non-ciliated club cells, which are unique to bronchioles. (wikipedia.org)
  • Exposure to particulate air pollution may compromise the integrity of the lung epithelium and lead to rapid increase in epithelial barrier permeability, as reflected by increased serum club cell concentrations. (wikipedia.org)
  • Movement
  • Haptotaxis plays a role in several kinds of diseases where the movement or aggregation of cells causes the symptoms. (wikipedia.org)
  • Movement of cells is vital for the function of the immune system, and especially for antigen presenting cells. (wikipedia.org)
  • human
  • Human fetal RPE were cultured on Electric Cell-substrate Impedance Sensing (ECIS) 96-well plates for 30-60 days to differentiate. (arvojournals.org)
  • SV40-immortalized human corneal epithelial (THCE) cells were cultured in Defined Keratinocyte Serum Free Medium containing normal D-glucose (NG, 5 mM), high D-glucose (HG, 25 mM) and high D-mannitol (HM, 20 mM). (arvojournals.org)
  • AF6 is a human multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. (biologists.org)
  • Lacritin targets a restricted group of epithelial cells (including human corneal epithelia), and not fibroblastic, glioma, or lymphoblastic cells. (wikipedia.org)
  • The pluripotency of the human amniotic epithelial cells makes them useful in treating and fighting diseases and disorders of the nervous system as well as other tissues of the human body. (wikipedia.org)
  • In harvesting embryonic stem cells, a human embryo is destroyed. (wikipedia.org)
  • antigen
  • Dendritic cells (one of the main antigen presenting cells in the immune system), move towards the lymph nodes after phagocytizing an antigen in order to present the antigen to T cells. (wikipedia.org)
  • One possible reason for this is that amniotic epithelial cells have low antigen levels that inhibit compatibility from a donor to the recipient. (wikipedia.org)
  • Also, these lab grown cells have shown altered gene expression causing a differing phenotype as well as differing antigen levels. (wikipedia.org)
  • Growth
  • Neural cells, for example, express growth-associated proteins, such as GAP-43, tubulin, actin, an array of novel neuropeptides, and cytokines that induce a cellular physiological response to regenerate from the damage. (wikipedia.org)
  • proteins
  • Biotinylated cell surface proteins from a lacritin-responsive cell were incubated with lacritin under conditions of physiological salt. (wikipedia.org)
  • Serum club cell proteins are used as a biomarker of lung permeability. (wikipedia.org)
  • The skin of older people is more easily damaged, and older cells do not proliferate as fast and may not have an adequate response to stress in terms of gene upregulation of stress-related proteins. (wikipedia.org)
  • In older cells, stress response genes are overexpressed when the cell is not stressed, but when it is, the expression of these proteins is not upregulated by as much as in younger cells. (wikipedia.org)
  • expression
  • After repeated treatments, gene expression of the whole population remained constant despite the substantial changes in cell behavior, morphology and cell numbers. (arvojournals.org)
  • An E-box motif (CACGTG) in the PAI-1 proximal promoter (located at nucleotides -160 to -165), previously shown to be necessary for serum-induced PAI-1 expression, was bound by nuclear factors from wound-stimulated but not quiescent, contact-inhibited, keratinocytes. (biologists.org)
  • Relative to intact cultures, scrape site-juxtaposed cells had significantly greater cytoplasmic and nuclear USF-1 immunoreactivity correlating with the specific in situ-restricted expression of PAI-1 transcripts/protein in the wound-edge cohort. (biologists.org)
  • novel
  • pI 4.6) displays a novel C-terminus that should be incapable of binding syndecan-1, and lacks cell survival activity. (wikipedia.org)
  • locomotion
  • We found that AQP9 facilitated cell locomotion at both the single and multi-cellular level. (ox.ac.uk)
  • inflammatory
  • The process of scarring is complex, it involves the inflammatory response and remodelling amongst other cell activities. (wikipedia.org)
  • stem cells
  • Amniotic epithelial cells are a form of stem cells extracted from the lining of the inner membrane of the placenta. (wikipedia.org)
  • These cells are known to have some of the same markers as embryonic stem cells, more specifically, Oct-4 and nanog. (wikipedia.org)
  • These transcription factors are the basis of the pluripotency of stem cells. (wikipedia.org)
  • Artificial heart valves and working tracheas, as well as muscle, fat, bone, heart, neural and liver cells have all been engineered using amniotic stem cells. (wikipedia.org)
  • Thus their use averts the controversy about embryonic stem cells. (wikipedia.org)
  • In particular, Fuchs researches skin stem cells, and their production of hair and skin. (wikipedia.org)
  • Scar
  • During early gestation fetal skin wounds have the remarkable ability to heal rapidly and without scar formation. (wikipedia.org)
  • It is important to note that the ability of fetuses to heal without scarring is wound size dependent and also age-dependent, whereby after a specific gestational age, usually 24 weeks in humans, typical scar formation will occur. (wikipedia.org)