• The Greenland wolf (taxonomic Latin: Canis lupus orion, Danish: grønlandsulv) is a subspecies of gray wolf that is native to Greenland. (wikipedia.org)
  • He also attributed the name Canis lupus arctos (Arctic wolf) to a specimen from Melville Island in the nearby Queen Elizabeth Islands, Canada. (wikipedia.org)
  • Both wolves are recognized as separate subspecies of Canis lupus in the taxonomic authority Mammal Species of the World in 2005. (wikipedia.org)
  • The Alaskan wolves spread to become the northern wolves referred to as Canis lupus arctos. (wikipedia.org)
  • Other authors have disagreed that the Greenland wolf is a separate subspecies of Canis lupus because of its close proximity to the range of the Arctic wolf. (wikipedia.org)
  • In 2019, a study mapped the entire mitochondrial genome of the Greenland wolf and confirmed that it fell within Canis lupus. (wikipedia.org)
  • Analysis of 353bp of cytochrome B and 296 bp of d-loop of the mitochondrial genome placed these two individuals in the same lineage of African wolf Canis lupus lupaster identified by Gaubert et al. (canids.org)
  • The mummified grey wolf ( Canis lupus ) was discovered by a gold miner excavating permafrost in Yukon, Canada, in July 2016, in the Klondike gold fields near Dawson City. (sciencealert.com)
  • Eastern wolves (Canis lycaon), specifically, have been the subject of significant controversy, being viewed as either a distinct taxonomic entity of conservation concern or a recent hybrid of coyotes (C. latrans) and grey wolves (C. lupus). (bvsalud.org)
  • However, two recent reports found that mitochondrial haplotypes of some African golden jackals aligned more closely to gray wolves ( Canis lupus ) [ 1, 2 ], which is surprising given the absence of gray wolves in Africa and the phenotypic divergence between the two species. (nova.edu)
  • We combine that with a review of the literature on Late Pleistocene Canis distributions to illuminate opportunities for ancient hybridization events between extinct Beringian grey wolves (C. lupus) and extinct large wolf-like coyotes (C. latrans orcutti) that we propose as a potentially unrecognized source of introgressed genomic variation within contemporary Canis genomes. (authorea.com)
  • These events speak to the potential origins of contemporary genomes and provide a new perspective on Canis ancestry, but do not influence/negate current conservation priorities of dwindling wolf populations with unique genomic signatures and key ecologically critical roles. (authorea.com)
  • The two wolf types found in India are represented by two isolated populations and believed to be two sub-species of Canis lupus. (org.in)
  • The Canis mtDNA HV1 database contains information about canine mitochondrial DNA HV1 sequences with reconciled annotation. (biomedcentral.com)
  • In addition, these findings provide further support for models in which conflicts between different genes in genomes can drive the process of speciation. (elifesciences.org)
  • Here we show that dogs have accumulated nonsynonymous changes in mitochondrial genes at a faster rate than wolves, leading to elevated levels of variation in their proteins. (slu.se)
  • Evidence for this can be found in the fact that modern dogs, unlike wolves, have genes that allow them to breakdown starch. (acanews.org)
  • This unit examines concepts such as the Mitochondrial Eve, Africa as the point of origin of our species, the human replacement of all other hominids, and the significant impact these vents have had on the genes of modern humans. (learner.org)
  • A relatively obvious approach to phylogenetic analysis of whole genomes is to extract as many genes as possible from the genome sequences, create a multiple sequence alignment from each of the genes and to concatenate all alignments. (biomedcentral.com)
  • Unusual mitochondrial genomes and genes. (umontreal.ca)
  • Wolfiness scores up to 10% are almost always due to ancient wolf genes that survived many generations, rather than any recent wolf ancestors. (embarkvet.com)
  • Mitochondrial DNA (mtDNA) is DNA that is located in mitochondria. (dadamo.com)
  • We generated 59 ancient mitochondrial DNA (mtDNA) sequences from European dogs (from 14,000 to 3000 years ago) as well as a high-coverage nuclear genome (28x) of an ancient dog dated to ~ 4800 calendar years before the present ( 12 ) from the Neolithic passage grave complex of Newgrange ( Sí an Bhrú ) in Ireland. (scienceintheclassroom.org)
  • But what is even more fascinating, is the fact that there appears to be three basic mitochondrial DNA (mtDNA) lineages which in themselves trace back to one original mother as mentioned. (adefenceofthebible.com)
  • Fruit fly larvae with a specific mitochondrial DNA (mtDNA) mutation showed a substantial increase in development when they were fed the high-carbohydrate banana diet. (earth.com)
  • Meachen and colleagues reconstructed Zhùr's mitochondrial genome - the genome found in the cells' energy-making structures called mitochondria that gets passed along the maternal line - finding similarities with both Beringian wolves, an extinct group that lived in ancient Yukon and Alaska, and Russian grey wolves. (sciencealert.com)
  • In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. (frontiersin.org)
  • Given the complexity of the biological function of mitochondria, researchers have begun to consider rescuing the injured cells through mitochondrial transfer, that is, replacing damaged mitochondria with healthy mitochondria from donor cells. (frontiersin.org)
  • However many proteins found in the mitochondria are encoded by nuclear DNA: some, if not most, are thought to have been originally part of the mitochondrial DNA but have since been transferred to the nucleus during evolution. (dadamo.com)
  • The existence of separate mitochondrial DNA suggests that, at one point, mitochondria were separate entities from their current host cells. (dadamo.com)
  • On the other hand, this research indicated that mitochondrial lineages are clearly distinguishable for the two species. (technopet.co.za)
  • Here, we re-analyze contemporary and ancient mitochondrial DNA genomes with Bayesian phylogenetic analyses to more accurately estimate divergence dates among lineages. (authorea.com)
  • Here, we extend the recently described Genome BLAST Distance Phylogeny (GBDP) strategy to compute phylogenetic trees from all completely sequenced plastid genomes currently available and from a selection of mitochondrial genomes representing the major eukaryotic lineages. (biomedcentral.com)
  • Meilan Solly at Smithsonian.com reports that researchers also looked at the mitochondrial lineages of dogs that lived in North and South America prior to European contact and compared them to 5,000 modern dogs, finding almost no trace of the indigenous dogs. (smithsonianmag.com)
  • In contrast, nuclear genome studies indicate eastern wolves are best described as a hybrid entity, but with unclear timing of hybridization events. (bvsalud.org)
  • Nuclear genome sequence and gene expression of an intracellular fungal endophyte stimulating the growth of cranberry plants. (umontreal.ca)
  • We would like to target mutations in the nuclear genome that are associated with metabolism, phenotype [i.e. physical attributes], and behavior. (smithsonianmag.com)
  • Phylogenetic methods which do not rely on multiple sequence alignments are important tools in inferring trees directly from completely sequenced genomes. (biomedcentral.com)
  • Nowadays, an increasing number of completely sequenced genomes are available and a growing field of phylogenetic research deals with the question of how to infer reliable phylogenies from this large amount of data to overcome the limitations of single-gene phylogenies. (biomedcentral.com)
  • Canine and wolf mitochondrial DNA haplotypes, which can be used for forensic or phylogenetic analyses, have been defined in various schemes depending on the region analyzed. (biomedcentral.com)
  • In 2018, a whole genome study of most North American wolf populations identified three distinct populations in the high arctic, including one novel and highly distinct wolf population that inhabits both Ellesmere Island, Canada and Greenland. (wikipedia.org)
  • To test the distinct-species hypothesis and understand the evolutionary history that would account for this puzzling result, we analyzed extensive genomic data including mitochondrial genome sequences, sequences from 20 autosomal loci (17 introns and 3 exon segments), microsatellite loci, X- and Y-linked zinc-finger protein gene ( ZFX and ZFY ) sequences, and whole-genome nuclear sequences in African and Eurasian golden jackals and gray wolves. (nova.edu)
  • These factors caused phylogenetics to enter an era of multi-locus analysis and is facilitated by availability of whole-genome sequencing [ 3 ]. (biomedcentral.com)
  • Oxford Nanopore and Illumina sequencing techniques were combined to generate the first complete nuclear and mitochondrial genomic sequences of Ae. (fmach.it)
  • We assembled a complete mitogenome of the intertidal spider Desis jiaxiangi and performed comparative mitochondrial analyses of data set comprising of Desis jiaxiangi and other 45 previously published spider mitogenome sequences, including that of Argyroneta aquatica . (biomedcentral.com)
  • We generated genetic sequences from 59 ancient dogs and a complete (28x) genome of a late Neolithic dog (dated to ~4800 calendar years before the present) from Ireland. (scienceintheclassroom.org)
  • We combined our ancient sample with 80 modern publically available full genome sequences and 605 modern dogs (including village dogs and 48 breeds) genotyped on the CanineHD 170,000 (170 K) single-nucleotide polymorphism (SNP) array ( 12 ). (scienceintheclassroom.org)
  • Dr. Natia Kopaliani, Dr. David Tarkhnishvili, and colleagues from the Institute of Ecology at Ilia State University in Georgia and from the Tbilisi Zoo in Georgia used a range of genetic techniques to extract and examine DNA taken from wolf and dog fur samples as well as wolf scat and blood samples. (sciencedaily.com)
  • If this change also affected other parts of the dog genome, it could have facilitated the generation of novel functional genetic diversity. (slu.se)
  • The domestication of wolves and the subsequent breeding of dogs can be viewed as one of humankind's oldest and largest genetic experiments and provides us with unique opportunities for research. (bvsalud.org)
  • These canines first appeared some 12,000 years ago and had different morphological and genetic features than the wolves found in Europe at the time. (acanews.org)
  • Genetic studies have found that the mitochondrial genomes of all modern dogs are most closely related to the canids of Europe. (acanews.org)
  • Natural selection was claimed by Darwin to give rise to new species, but in the case of wolves natural selection had obviously eliminated genetic novelties, and therefore had an anti-evolutionary effect. (creationfactfile.com)
  • Thus, Vilà and his colleagues decided to compare the mitochondrial DNA of dogs and wolves in an attempt to understand the genetic consequences of these species' different lifestyles: domesticated versus wild. (technopet.co.za)
  • Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study. (ucl.ac.uk)
  • They also sequenced her mitochondrial DNA, the genetic material passed down directly from mother to offspring. (templeilluminatus.com)
  • In 2009, two genetic researchers at the Wyss Institute at Harvard Medical School in Boston, Massachusetts, Harris Wang and George Church, developed the technology during a time when researchers could only edit one site in an organism's genome at a time. (asu.edu)
  • This is shown by the graph which is courtesy of Dr John Stanford from his book Genetic Entropy & the Mystery of the Genome , 2005. (adefenceofthebible.com)
  • Mitochondrial DNA analyses show some evidence of eastern wolves being North American evolved canids. (bvsalud.org)
  • Additional analyses of ancient and modern mitochondrial DNA revealed a sharp discontinuity in haplotype frequencies in Europe. (scienceintheclassroom.org)
  • In 2018, it was estimated that the total population of the Greenland wolf was about 200, but with significant uncertainty due to its remote range. (wikipedia.org)
  • However, in 1997, there was a decline in the wolf populations and their prey, muskoxen (Ovibos moschatus) and Arctic hares (Lepus arcticus) across arctic Canada. (wikipedia.org)
  • The recovery of the wolf populations came after when summer weather conditions returned to normal. (wikipedia.org)
  • June 29, 2022 An international group of geneticists and archaeologists have found that the ancestry of dogs can be traced to at least two populations of ancient wolves. (sciencedaily.com)
  • More recent studies suggest humans may have first domesticated dogs some 6,400-14,000 years ago when an initial wolf population split into East and West Eurasian wolves, which were domesticated independently of each other and gave birth to 2 distinct dog populations before going extinct. (acanews.org)
  • If wolf populations already contained many of the variations we see in domestic dogs, then dogs have reproduced after their kind - just as Genesis says, even if you arbitrarily give the wild wolf and the domestic dog different species names. (creationfactfile.com)
  • Genome-wide linkage analysis of serum creatinine in three isolated European populations. (tum.de)
  • Combined, these results suggest that dogs may have been domesticated independently in Eastern and Western Eurasia from distinct wolf populations. (scienceintheclassroom.org)
  • Disentangling ancestry and timing of hybridization in Great Lakes wolves, eastern Canadian wolves, red wolves, and eastern coyotes is most often partitioned into a 2-species model that assigns all ancestry to grey wolves and/or coyotes, and a 3-species model that includes a third, North American evolved eastern wolf genome. (authorea.com)
  • This isn't uncommon in modern wolves, which have been shown to seasonally switch to aquatic diets in Alaska. (sciencealert.com)
  • Brian Handwerk as Smithsonian.com reports that dogs and modern wolves split from a common ancestor between 15,000 to 40,000 years ago. (smithsonianmag.com)
  • According to her DNA, however, the mummified puppy, named Zhùr, came from a population that's among the ancestors of all modern wolves. (templeilluminatus.com)
  • The domestication of dogs caused a dramatic change in their way of life compared with that of their ancestor, the gray wolf. (slu.se)
  • This suggests that a major consequence of domestication in dogs was a general relaxation of selective constraint on their mitochondrial genome. (slu.se)
  • This separate domestication of wolf groups supports the theory that there were 2 domestication incidents for dogs. (acanews.org)
  • Since the 2000s, the frequency of wolf depredation on cattle has increased in Georgia, and there were several reports of attacks on humans. (sciencedaily.com)
  • Reports suggested that, unlike wild wolves, wolf-dog hybrids might lack fear of humans, so we wanted to examine the ancestry of wolves near human settlements to determine if they could be of hybrid origin with free-ranging dogs such as shepherds," she added. (sciencedaily.com)
  • Wolves were the first animal species to become domesticated by humans, approximately 30,000-50,000 years ago. (bvsalud.org)
  • First mistakenly classified as a wolf, the Bonn-Oberkassel dog was buried with two humans around 14,220 years ago. (acanews.org)
  • It has been hypothesized that humans in the early Holocene era, around 10,000 years ago, would have chosen wolf puppies for behaviors like tameness and friendliness towards people. (acanews.org)
  • Analysis of the two species ' genomes has revealed differences that some scientists believe are a result of dogs being subject to artificial selection imposed by humans. (technopet.co.za)
  • Remember, both dogs and wolves evolved from a common ancestral wolf species, so wolves are an ideal control with which to study the consequences of dogs' life with humans. (technopet.co.za)
  • This is accomplished in humans by sequencing one or more of the hypervariable control regions (HVR1 or HVR2) of the mitochondrial DNA. (dadamo.com)
  • This animation illustrates the experiments that Ajit Varki, Wolf Enard, and Svente Paabo carried out to compare the gene expression between chimpanzees, humans, and an outgroup, the Rhesus monkey. (learner.org)
  • Southeastern Canada is inhabited by an amalgam of hybridizing wolf-like canids, raising fundamental questions regarding their taxonomy, origins, and timing of hybridization events. (bvsalud.org)
  • Robert Wayne, an evolutionary biologist at John Hopkins University commented that mutations tended to accumulate more quickly in mitochondrial DNA than in the main store of DNA in the nucleus and therefore, "Much of the variation we see in dogs may have to do with pre-existing variation from the ancestral wolf-dog population. (creationfactfile.com)
  • Mutations of mitochondrial DNA can lead to a number of illnesses including exercise intolerance and Kearns-Sayre syndrome (KSS), which causes a person to lose full function of their heart, eye, and muscle movements. (dadamo.com)
  • The puppy's genome suggested that she'd lived sometime between 75,000 and 56,000 years ago, based on the rate at which wolf DNA collects mutations over time. (templeilluminatus.com)
  • By comparing genomic signatures from 71 mitochondrial and seven nuclear genomes of ancient North American and Siberian dogs spanning a period of 9,000 years, the research team was able to gain a clearer picture of the history of the first canine inhabitants of the Americas. (illinois.edu)
  • Aside from being the most complete ice age wolf ever discovered, Zhùr's mummy was also particularly important to researchers because it was uncovered in North America. (sciencealert.com)
  • Having such an intact specimen to study also gave the researchers an opportunity to look at what ice age wolves were eating. (sciencealert.com)
  • We know dogs evolved from wolves, and researchers and geneticists have extensively studied canines to try and pin down the exact moment in history when the first dog walked the Earth. (acanews.org)
  • Researchers at Uppsala University have compared the complete mitochondrial genomes from fourteen domestic dogs, six wolves, and three coyotes. (creationfactfile.com)
  • The fact that mitochondrial DNA is maternally inherited enables researchers to trace uterine lineage far back in time. (dadamo.com)
  • The researchers found that a common mitochondrial DNA mutation plays a role in obesity and other health issues associated with a diet high in carbohydrates. (earth.com)
  • In Greenland, about 90% of the wolf's range falls within the boundaries of the Northeast Greenland National Park, where the wolf population was estimated in 1998 to be 55 wolves due to lack of prey. (wikipedia.org)
  • Hybridization of wolves with shepherd dogs in the Caucasus region might be more common, and more recent, than previously thought, according to new research. (sciencedaily.com)
  • Dog owners in the Caucasus Mountains of Georgia might want to consider penning up their dogs more often: hybridization of wolves with shepherd dogs might be more common, and more recent, than previously thought, according to a recently published study in the Journal of Heredity . (sciencedaily.com)
  • This included hybridization between wolves and the shepherd dogs used to guard sheep from wolf attacks. (sciencedaily.com)
  • The research team examined maternally-inherited DNA (mitochondrial DNA) and microsatellite markers to study hybridization rates. (sciencedaily.com)
  • The proposed models address recent or sometimes late Holocene hybridization events but have largely ignored Pleistocene era opportunities for hybridization that may have impacted the current mixed genomes in eastern Canada and the United States. (authorea.com)
  • Your dog's Wolfiness Score is not a measure of recent dog-wolf hybridization and does not necessarily indicate that your dog has some recent wolf ancestors. (embarkvet.com)
  • Mitochondrial and eukaryotic origins: a critical review. (umontreal.ca)
  • One of these wolf, locally called Himalayan wolf (HW) or Tibetan wolf, is found only in the upper Trans-Himalayan region from Himachal Pradesh to Leh in Kasmir and is considered to be C. lupus chanco. (org.in)
  • The other relatively larger population is of Indian Gray wolf (GW) that is found in the peninsular India and considered to be C. lupus pallipes. (org.in)
  • The wolves of Greenland and Ellesmere Island prey on any easily obtainable species, with hare forming an important food source. (wikipedia.org)
  • The first complete genomic sequence also provides a significant leap in the general understanding of this species, opening the possibility for future genome-related studies, such as the detection of 'Single Nucleotide Polymorphism' markers. (fmach.it)
  • We hypothesize that this new life style changed the selective forces that acted upon the species, which in turn had an effect on the dog's genome. (slu.se)
  • Associated defects in energy homeostasis, cellular and mitochondrial quality control, production and removal of toxic free radical species, and the inflammatory response are explored to define underlying causes of diseases that primarily afflict the elderly. (omrf.org)
  • Both these wolves are accorded endangered species status under the Indian Wildlife Protection Act. (org.in)
  • As of April 2020, there were records for 88,254 complete mitogenomes for animals in the NCBI database ( https://www.ncbi.nlm.nih.gov/nuccore/?term=mitochondrion+complete+genome ). (biomedcentral.com)
  • Scientists found recent hybrid ancestry in about ten percent of the dogs and wolves sampled. (sciencedaily.com)
  • About two to three percent of the sampled wolves and dogs were identified as first-generation hybrids. (sciencedaily.com)
  • The study also found that about a third of the dogs sampled shared relatively recent maternal ancestry with local wolves, not with wolves domesticated in the Far East, where most experts believe dogs were first domesticated. (sciencedaily.com)
  • For example, many experts agree that dogs started to separate from wolves starting around 16,000 years before present in Southeastern Asia. (acanews.org)
  • But until we uncover more evidence, it will be difficult to know for sure exactly when dogs completely separated from their wolf ancestors. (acanews.org)
  • Paleolithic dogs first began to appear at the same time, developing shorter skulls and wider braincases and snouts compared to their wolf ancestors. (acanews.org)
  • They found the domestic dogs showed a greater variety in their DNA than the wolves, whom they are believed to have evolved from. (creationfactfile.com)
  • Dogs' closest living relatives are wolves. (technopet.co.za)
  • If dogs evolved from wolves, which seems to be the case, then wolves must have had the capacity for this diversity somewhere in their genomes. (technopet.co.za)
  • Vila et al have published studies tracing the matrilineal descent of domestic dogs to wolves. (dadamo.com)
  • The dogs were not domesticated North American wolves, as some have speculated, but likely followed their human counterparts over a land bridge that once connected North Asia and the Americas, the study found. (illinois.edu)
  • As a graduate student at Illinois, Kelsey Witt led the mitochondrial DNA genome work on a newly published study of ancient dogs. (illinois.edu)
  • This is the first comprehensive genomic study of ancient dogs in the Americas to analyze nuclear DNA, which is inherited from both parents, along with mitochondrial DNA, which is passed down only from mothers to their offspring. (illinois.edu)
  • Your dog's Wolfiness Score is based on hundreds of markers across the genome where dogs (or almost all of them) are the same, but wolves tend to be different. (embarkvet.com)
  • By finding rare dogs carrying an ancient variant at a certain marker, we can make associations with behavior, size, metabolism, and development that likely caused these unique signatures of "doggyness" in the genome. (embarkvet.com)
  • We know that dogs are descended from wolves, but when and where they were domesticated has been up for debate. (scienceintheclassroom.org)
  • And although this dog was likely able to digest starch less efficiently than modern dogs, it was able to do so more efficiently than wolves ( 12 ). (scienceintheclassroom.org)
  • Dr. Elinor Karlsson discusses the genomic differences between dogs and wolves, in particular the ability to digest starch. (scienceintheclassroom.org)
  • Think of the great range of dogs that exist today which originally came from a native wolf-like dog. (adefenceofthebible.com)
  • In 2016, a study based on 582 base pairs of mitochondrial DNA indicated that Greenland wolves belong to one haplotype that had been previously found among other North American wolves, which indicates their female lineage originated from North America. (wikipedia.org)
  • Genome-Wide Evidence Reveals that African and Eurasian Golden Jackals " by Klaus-Peter Koepfli, John Pollinger et al. (nova.edu)
  • C. anthus (African golden wolf) and C. aureus (Eurasian golden jackal). (nova.edu)
  • The woman who possessed the most recent common ancestor of all mitochondrial DNA variants currently in the human population. (learner.org)
  • Zhùr's mitochondrial DNA fit right into that group of closely related animals, or clade, with a common ancestor that lived between 86,000 and 67,500 years ago. (templeilluminatus.com)
  • She is the most complete wolf specimen ever found from the ice age," said lead author Julie Meachen, an associate professor of Anatomy at Des Moines University in Iowa. (sciencealert.com)
  • But because mitochondrial DNA gets passed down directly from mother to puppy, Meachen and her colleagues could tell that Zhùr wasn't a direct ancestor of the wolves that roam the Klondike today. (templeilluminatus.com)
  • If Zhùr couldn't tell Meachen and her colleagues exactly what happened to a whole population of Klondike wolves, she could at least tell quite a bit of her own story. (templeilluminatus.com)
  • In 2021, the entire genome sequence of the Greenland wolf was mapped to aid further research. (wikipedia.org)
  • Church helped to develop and refine techniques with which to describe the complete sequence of all the DNA nucleotides in an organism's genome, techniques such as multiplex sequencing, polony sequencing, and nanopore sequencing. (asu.edu)
  • Zhùr and her clade are the ancestors of every wolf in the world (except possibly the high-altitude Himalayan wolves , which have apparently been doing their own thing for hundreds of thousands of years, according to a study earlier in 2020). (templeilluminatus.com)
  • During the last 15 years, the canine community has heavily relied on a reference genome derived from the female Boxer Tasha. (bvsalud.org)
  • Our results indicate that, at this taxonomic level, plastid genomes are much more valuable for inferring phylogenies than are mitochondrial genomes, and that distances based on breakpoints are of little use. (biomedcentral.com)
  • This shows how one female ancestor passed on her mitochondrial DNA to everyone living today. (learner.org)
  • As expected from such a tiny population, genetics have shown that the Greenland wolf is quite inbred. (wikipedia.org)
  • A series of essays (one for each chromosome in the human genome) that discuss various aspects of human genetics and evolution. (learner.org)
  • In: Organelle Genetics 2012, Part 2: evolution of organelle genomes and gene expression (C. Bullerwell, ed), Springer-Verlag Heidelberg, Germany, p. 41-77. (umontreal.ca)
  • Multiplex Automated Genome Engineering, or MAGE, is a genome editing technique that enables scientists to quickly edit an organism's DNA to produce multiple changes across the genome. (asu.edu)
  • The intercellular mitochondrial transfer was reported for the first time by Spees and colleagues in 2006. (frontiersin.org)
  • Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. (frontiersin.org)
  • On the nosology and pathogenesis of Wolf-Hirschhorn syndrome: genotype-phenotype correlation analysis of 80 patients and literature review. (medscape.com)
  • Pathogenesis of Wolf-Hirschhorn syndrome is multigenic. (medscape.com)
  • The concept of the Mitochondrial Eve is based on the same type of analysis, attempting to discover the origin of humanity by tracking the lineage back in time. (dadamo.com)
  • Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis. (tum.de)
  • Comprehensive analysis of Wolf-Hirschhorn syndrome using array CGH indicates a high prevalence of translocations. (medscape.com)
  • Genotype-phenotype correlation in 21 patients with Wolf-Hirschhorn syndrome using high resolution array comparative genome hybridisation (CGH). (medscape.com)
  • Therefore, patients with cardiovascular diseases would fail to achieve the desired outcomes by using these mitochondrial-targeted drugs ( 5 ). (frontiersin.org)
  • A recent genomic study has shown that wolves of Ellesmere Island, Canada, likely should be included in the same subspecies, a view also supported by earlier morphological reviews. (wikipedia.org)
  • The study was undertaken as part of Dr. Kopaliani's work exploring human-wolf conflict in Georgia. (sciencedaily.com)
  • We expected to identify some individuals with hybrid ancestry, but it was quite surprising that recent hybrid ancestry was found in every tenth wolf and every tenth shepherd dog," said study co-author Tarkhnishvili. (sciencedaily.com)
  • As such, the remains were much easier to access and study, and they also provided a rare opportunity to see where North American wolves originated, she said. (sciencealert.com)
  • What is unique about this study is we've identified one mutation in the mitochondrial genome, that when fed a specific diet is advantageous and causes the frequency of flies in a population cage to increase," said Professor Ballard. (earth.com)
  • Animals moved freely back and forth between the continents, which is why Pleistocene wolves unearthed across Eurasia and North America are all so closely related. (templeilluminatus.com)
  • Sometime in the last 56,000 years or so, the Klondike wolf population died out or left the area, and another group of wolves-one less closely related to Zhùr-replaced it. (templeilluminatus.com)
  • This had already been suggested in a morphological review in 1983, where wolves of the Queen Elizabeth Islands (the main island is Ellesmere) were placed in C. l. orion together with wolves of Greenland. (wikipedia.org)
  • The laboratories that comprise our Program investigate distinct aspects of mitochondrial and cellular metabolism, identifying alterations that occur with age that are exacerbated by obesity and diabetes. (omrf.org)
  • Spectrum of epilepsy and electroencephalogram patterns in Wolf-Hirschhorn syndrome: experience with 87 patients. (medscape.com)