Wherein heterocyclic compounds aza compounds. Medical search. Frequent questions

Several types of asymmetric reactions have been developed involving different bonds formation, C-O, C-N and C-C, highlighting the urgency to go ahead in the search for new ligands and synthetic methodologies in order to improve the control over the reaction selectivity and activity and thus, to increase the applications in the synthesis of heterocyclic scaffolds and biologically active compounds. (unimi.it)
Phthalhydrazide is one of the useful starting material toward the synthesis of heterocyclic compounds, and considered as a valuable structural unit in organic synthesis due to its significant pharmacological and biological activities. (heterocycles.jp)

The composition of the conference covered a wide range of organic chemists working in the field of biologically active heterocyclic compounds. (cbcconf.com)

The Chemistry of Heterocyclic Compounds. (cbcconf.com)
This Conference continues the series of international meetings first held in 2001 on the Chemistry and Biological Activity of Synthetic and Natural Compounds. (cbcconf.com)
Journal of heterocyclic chemistry, 20(6), 1509-1512. (edu.ng)
Investigations of the chemical transformations of such compounds are certainly of interest for theoretical, practical and synthetic organic chemistry, as well as for the search of compounds with favorable practical properties, such as thermal stability, electrical conductivity (even superconductivity), biological activity, nonlinear optical effects, etc. [ 39 ]. (degruyter.com)
Progress in Heterocyclic Chemistry, G. Gribble and John Joule Eds. (uva.es)
Consequently, this branch of Chemistry can address and solve particularly unique problems ranging from catalytic industrial production issues to the synthesis and fabrication of compounds and materials relevant to nanotechnology. (uga.edu)

In particular, PAHs are compounds containing only carbon and hydrogen atoms (i.e. unsubstituted PAHs and their alkyl-substituted derivatives), while the more general name of "polycyclic aromatic compounds" also includes functional derivatives (e.g. nitro-PAHs) and heterocyclic analogues (e.g. aza-areas). (umanaloggia.it)
The aza-Michael products have been targeted as truncated ritonavir analogues for investigation as potential HIV -1 protease inhibitors, and representative compounds have been subjected to enzyme inhibition assays to explore the extent and type of inhibition. (ru.ac.za)

This method witnessed as a powerful tool for the construction of a diverse range of biological active quinoline scaffolds and other nitrogen containing heterocyclic compounds due to its operational modesty, high atom economy, regio- and stereoselectivity. (heterocycles.jp)

As one of the longest-running Gordon Research Conferences, the 2023 Heterocyclic Compounds GRC will continue to provide a platform for disclosures of new strategies for the discovery, synthesis, incorporation, and application of powerful heterocycles. (grc.org)

The present report focuses on the advancement of aza-Diels-Alder reaction for the synthesis of optically active and inactive quinoline derivatives. (heterocycles.jp)
These polymaleimide derivatives can be active catalysts for the selective oxidation of heterocyclic compounds to quinoline and indole via the recycling of -C=O and -C-OH groups, which was confirmed by tracing the reaction with GC-MS using maleimide as the catalyst and by FT-IR analysis with polymaleimide as the catalyst. (nature.com)
Catalytic performance exploration showed that these polymaleimide (PMI) derivatives can be active catalysts for the selective oxidation of heterocyclic compounds to quinoline and indole via the recycling of -C=O and -C-OH groups. (nature.com)
The Baylis-Hillman products have been explored as substrates for aza-Michael reactions using various amino derivatives including protected amino acids in the presence of the tetrabutylammonium bromide (TBAB) and the ionic liquid, 3-butyl-1- methylimidazoleboranetetrafluoride (BmimBF₄), as catalysts. (ru.ac.za)
This present disclosure is related to the field of to N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxamide compounds and their derivatives and to the use of these compounds as fungicides. (justia.com)
TimTec new selection of privileged structures includes diverse derivatives of 150 Mesoionic , 50 Aminomorpholine , and 340 Dihydropyridine compounds available in sets and for cherry-picking. (timtec.net)

New pathways for the synthesis of various carbohydrates were developed using inexpensive and abundantly available compounds as starting materials, and by the application of chemo-enzymatic reactions. (keio.ac.jp)
The increased stability of the intermediates (such as compounds of formula (III)) against competing hydrolysis reactions, removes the need to work under anhydrous conditions. (allindianpatents.com)
Hydroacylation reactions and aza-benzoin reactions have attracted considerable attention from experimental chemists. (cyberleninka.org)
reported an interesting reaction of N-heterocyclic carbene (NHC)-catalyzed addition of aldehyde to enamide, in which both hydroacylation and aza-benzoin reactions may be involved. (cyberleninka.org)
The work should provide valuable insights for rational design of switchable NHC-catalyzed hydroacylation and aza-benzoin reactions with high stereoselectivity. (cyberleninka.org)
Furthermore, catalytic cycloaddition reactions of benzohydroxamic acids / semicarbazones with diazo compounds / alkynes were also accomplished. (edu.hk)
Inspired by our previous finding on the rhodium(III)-catalyzed arene C-H coupling reactions with diazomalonates, we envisioned that a transformation involving formal [4 + 1] cycloaddition of diazo compounds with O-acetyl benzohydroxamic acids should give oxisoindoles as products via reductive elimination of the σ-allylrhodacycle. (edu.hk)
Diazo compounds having esters, phenylsulfone, cyano and phosphonate groups are good coupling partners, and their reactions with benzohydroxamic acids gave the corresponding oxisoindoles in up to 90% yields. (edu.hk)
Kinetics and mechanisms of the gas-phase reactions of the hydroxyl radical with organic compounds under atmospheric conditions. (cdc.gov)

Industrial hygiene surveys were conducted, and air samples were collected for analysis of polynuclear aromatic hydrocarbons, polynuclear aza heterocyclic hydrocarbons, aromatic amines, metals, common toxic gases, and other organic compounds. (cdc.gov)
Sampling results indicated that workers were exposed to polynuclear aromatic hydrocarbons in the low microgram per cubic meter range, with the light molecular weight compounds in higher concentrations than the four through seven ring compounds. (cdc.gov)
Physical properties and chemical reactivity of alternant hydrocarbons and related compounds. (cas.cz)

Diversity-oriented synthesis is a synthetic method for producing a large number of compounds with different molecular skeletons from a single starting material. (keio.ac.jp)

As powerful organocatalysts, N-heterocyclic carbenes (NHCs) have been widely used in various carbon-carbon and carbon-heteroatom bonds forming reactions1'2. (cyberleninka.org)

The aromatic heterocycles include such compounds as pyridine, where nitrogen replaces one of the СН groups in benzene, and pyrrole , in which the aromatic sextet is supplied by the four electrons of the two double bonds and the lone pair on nitrogen. (medmuv.com)
1,3-Oxathiolan-5-ones are a hitherto very poorly studied class of sulfur heterocycles some of which have been shown to be important precursors for HIV drugs or bioactive, anticarcinogenic compounds. (uni-leipzig.de)
In recent years, however, new developments towards the enantioselective synthesis of various heterocycles and other useful compounds have evolved which take advantage of the unique properties of chiral Pd-aqua complexes. (uni-leipzig.de)

Heterocyclic compounds are cyclic compounds in which one or more ring atoms are not carbon (that is, hetero atoms). (medmuv.com)
The nonaromatic compounds have physical and chemical properties that are typical of the particular hetero atom. (medmuv.com)

The imino halide products are intermediates in the preparation of antibiotic compounds. (gc.ca)

A facile nickel-catalyzed oxidation of primary alcohols with tetrabutylammonium peroxydisulfate in the presence of ammonium hydrogen carbonate under basic aqueous conditions provides access to various aliphatic, aromatic and heterocyclic nitriles in excellent yields with very high purity. (organic-chemistry.org)

The aza-Diels-Alder reaction is a [4+2] cycloaddition, involving the insertion of nitrogen atom into dienes or dienophiles. (heterocycles.jp)
The addition of NHC to aldehydes formed Breslow intermediate, which can go through cross-coupling with enamide via hydroacylation reaction or its imine isomer via aza-benzoin reaction. (cyberleninka.org)
The aza-benzoin reaction requires relatively lower free energy barrier than the hydroacylation reaction. (cyberleninka.org)
Interestingly, both hydroacylation and aza-benzoin reaction mechanisms may be involved in the special reaction, and some important mechanistic questions need to be answered. (cyberleninka.org)
2) The Breslow intermediate can react with 2 via hydroacylation pathway, while it can also react with 2' via aza-benzoin reaction pathway. (cyberleninka.org)
Total synthesis of the fused heterocyclic natural product based on the microwave-assisted azaelectrocyclic reaction and seeking of lead compound. (nii.ac.jp)
Both tungsten compounds are formed by reaction of water and oxygen with the acetylene complex PPh 4 [WCl 5 (Ph - C ≡ C - C (Br) = C(Br) -Ph)] in CH 2 Cl 2 solutions, and in the presence of PPh 4 Cl. (degruyter.com)
Steric interactions controlling the syn diastereofacial selectivity in the [3+2] cycloaddition reaction between acetonitrile axide and 7-oxanorborn-5-en-2-ones. (luisrdomingo.com)

Polycyclic nitrogen compounds. (edu.ng)

In compound (I), the pyridine rings of the two independent molecules adopt different conformations, i.e. syn and anti, with respect to the methylene bridge. (bvsalud.org)
In contrast, in compound (II), the pyridine rings of both molecules have an anti conformation and the two independent molecules are linked by carbonyl-carbonyl interactions, as well as by C-H...O and C-H...N contacts. (bvsalud.org)

New 6‐aza‐1,2,3,3a‐tetrahydropyrrolo[1,2‐α]quinoxalin‐4‐one (III) and 4‐aza‐7,8,9,10‐tetrahydropyrido[1,2‐α]‐quinoxalin‐6‐one (IV) were prepared by selective hydrogen transfer reductive cyclisation of esters of N‐(2‐nitro‐3‐pyridyl)pyrrolidine‐2‐carboxylic acid and N‐(2‐nitro‐3‐pyridyl)piperidine‐2‐carboxylic acid (Xb and XIb) respectively. (edu.ng)
Compound showed selective anti-HIV-1 activity thanks to its ability to inhibit the reverse transcriptase. (bvsalud.org)

The more polar characteristic of C=N group in the imine isomers, and the more advantageous stereoelectronic effect in the carbon-carbon bond forming transition states in aza-benzoin pathway were identified to determine that the imine isomer can react with the Breslow intermediate more easily. (cyberleninka.org)
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. (lookformedical.com)
In particular, we are interested in the synthesis, stabilization, and structure of compounds containing multiple bonds between heavier main group elements (such as gallium and lead) and extending the concept of aromaticity beyond carbon ring systems to metallic ring systems-a phenomenon known as metalloaromaticity . (uga.edu)

Aliphatic cyclic and acyclic hydroxylamines containing benzyl and heterocyclic moieties were tolerated. (edu.hk)

During each formation process, PAHs are always present as a class (never as individual compounds) in complex mixtures containing other substances and chemical classes. (umanaloggia.it)
This is determined by a peculiar chemical behavior of such compounds due to mutual influence of the metallocene and heterocyclic moieties. (degruyter.com)
1.6 What do standard heats of formation tell us about chemical bonding and ground-state properties of organic compounds? (dattanibookagency.in)

Furthermore, the hydroxylated products can readily be converted into vicinal tricarbonyl compounds, which are useful synthetic precursors. (organic-chemistry.org)

Diethyl azodicarboxylate, conventionally abbreviated as DEAD and sometimes as DEADCAT, is an organic compound with the structural formula CH3CH2−O−C(=O)−N=N−C(=O)−O−CH2CH3. (wikipedia.org)
In particular, "diversity-enhanced extracts," which combine diversity-oriented synthesis with search for natural compounds, can yield a group of new compounds with structural diversity that exceeds that of natural compounds obtained from plants and microorganisms. (keio.ac.jp)

and (f) kits comprising such compounds, salts, and compositions. (justia.com)

Capillary chromatographic analysis of volatile organic compounds in the indoor environment. (cdc.gov)

The interest in oxazoline compounds bearing ferrocenyl substituents in the molecules can be traced back to the discovery of ferrocene [ 37 ]. (degruyter.com)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (lookformedical.com)
These intriguing compounds are speculated to play a pivotal role in self-defense and increasing venom toxicity and could also offer promising biotechnological applications as small bioactive molecules. (bvsalud.org)
In both compounds, the asymmetric unit consists of two independent molecules (Z' = 2). (bvsalud.org)

The complex interactions leading to a wide range of biological activity can be probed, enhanced, and harnessed through heterocyclic compounds. (grc.org)

It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group. (lookformedical.com)

The observed inertness is attributed to the stability of the aza-rhodacyclic complex, which should be difficult to dissociate for diazo coordination. (edu.hk)

An attractive feature for NHCs is that they can catalyze the polarity reversal of various carbonyl compounds and generate acyl anion equivalents, which provide an elegant access to a wide range of organic transformations3'4. (cyberleninka.org)

The characterization of the new compounds was done by IR, 1 H- and 13 C-NMR spectroscopy, mass-spectrometry, elemental analysis and X-ray diffraction studies. (degruyter.com)

Our laboratory has been studying difficult problems relating to fundamental issues of structure and bonding in organometallic compounds. (uga.edu)

We anticipated that isoindoles could be prepared by the formal [4 + 1] cycloaddition of O-carboxylates oximes with diazo compounds. (edu.hk)

By separating, purifying, and structurally determining these extracts, we can construct a library of structurally diverse compounds and obtain seed compounds for drug discovery research. (keio.ac.jp)

In fact, many medicines have been developed from natural compounds produced by plants, fungi, bacteria, and other microorganisms. (keio.ac.jp)
As a new drug discovery resource, we will focus on " unexploited organisms" which are different from conventionally used organisms, such as plants, fungi, and bacteria, for the search of natural compounds. (keio.ac.jp)

Glycosylated compounds in which there is an amino substituent on the glycoside. (lookformedical.com)

Originally discovered by Sodeoka 25 years ago, they readily form reactive chiral Pd enolates upon deprotonation of b-dicarbonyl compounds and simultaneously, a Brønsted acid liberated from the catalyst activates the electrophile. (uni-leipzig.de)

The X-ray structure, IR, Raman, 1 H NMR , and 13 C NMR spectra of this first organogermyl magnesium compound are reported. (degruyter.com)
The present subject matter provides a crystalline form of the compound having the following structure: wherein the crystalline form is a polymorph, hydrate or solvate. (justia.com)

These compounds interact well with biomolecules and are able to cross cellular membranes while having lower toxicity and being non-steroidal. (timtec.net)

In addition, we aim to use the substances obtained as seed compounds for the development of pharmaceuticals, as well as for the development of substances useful for life science research. (keio.ac.jp)

Mesoionic compounds are known to have anti-infective, anti-inflammatory, antitumoral activities, and superoxide radical scavenging ability (3). (timtec.net)
V. Evaluation of antiinflammatory and antimicrobial activities of some N-heterocyclic trifluoroacetamides. (timtec.net)

We conduct research to find natural product that can be used as resources for drug discovery, or to create them using natural compounds as motifs. (keio.ac.jp)
On the other hand, as a result of the vigorous search for natural compounds, new natural compounds are being depleted. (keio.ac.jp)
Therefore, it is not possible to conduct innovative drug discovery research by simply searching for natural compounds in the conventional way. (keio.ac.jp)

Students engaged in this research will gain valuable experience in both organic and inorganic synthesis and become proficient in the synthesis and manipulation of air-sensitive compounds and materials (a very valuable technique in both the academic and industrial communities). (uga.edu)

The spirocyclopropyl oxindole being a privileged scaffold, some of the synthesized compounds were selected for biological evaluation. (bvsalud.org)

The heterocyclic motif was confirmed by X-ray diffraction analysis. (uni-leipzig.de)

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes3

Synthesis of heterocyclic2

Biologically active1

Chemistry6

Analogues2

Scaffolds1

20231

Derivatives6

Reactions9

Hydrocarbons3

Molecular1

Carbenes1

Heterocycles3

Hetero2

Intermediates1

Nitriles1

Reaction8

Nitrogen1

Pyridine2

Selective2

Carbon3

Aliphatic1

Chemical3

Synthetic1

Structural2

Salts1

Volatile1

Molecules4

Biological activity1

Organic compound1

Stability1

Equivalents1

Characterization1

Fundamental1

Cycloaddition1

Extracts1

Bacteria2

Amino1

Catalyst1

Structure2

Lower1

Substances1

Activities2

Natural3

Materials1

Evaluation1

Analysis1