Wherein hla a1 antigen. Medical search. Frequent questions

HLA A*01:01-C*07:01-B*08:01) is a multigene haplotype that covers the MHC Class I region of the human major histocompatibility complex on chromosome 6. (wikipedia.org)
The haplotype can be written in an extended form covering the major histocompatibility loci as follows: HLA A*01:01 : Cw*07:01 : B*08:01 However, there are many other gene-alleles within the haplotype. (wikipedia.org)
The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
We have mapped the T cell recognition of MCPyV by use of a novel technology platform for T-cell enrichment and combinatorial encoding of histocompatibility antigen (HLA) class I multimers. (biomedcentral.com)
Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
I am section editor 'HLA in solid organ transplantation' of the HLA journal, and member of the scientific committee of both the European Federation for Immunogenetics (EFI), and the American Society of Histocompatibility and Immunogenetics (ASHI). (lumc.nl)
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Our identification of the first non-human primate-specific minor histocompatibility antigen now published at Frontiers in Immunology. (wisc.edu)
OBJECTIVE- HLA-DRB1* 03 -DQB1* 0201 /DRB1* 04 -DQB1* 0302 ( DR3/4-DQ8 ) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. (diabetesjournals.org)

In Africa A1-B8 and India A1-B8 is associated with other genes and other variants of A*01 and B*08 Philosophically, A1-B8 is more than just two gene-alleles. (wikipedia.org)
This disequilibrium made it appear that A1 and other class I gene-alleles were disease factors, when these alleles were only attached to a long segment of conserved DNA that had disease associated genes on the other end. (wikipedia.org)
Researchers have identified hundreds of different versions (alleles) of the HLA-DQA1 gene, each of which is given a particular number (such as HLA-DQA1*05:01 ). (medlineplus.gov)
Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)
For example, cer- countries), and prevention and treatment of tain distributions of HLA class I alleles were opportunistic infections and cancers delay the observed in uninfected female commercial sex onset of AIDS and increase the life expectancy workers in Africa (13,14) and Thailand (11), who of HIV-infected persons. (cdc.gov)
Circulating T cells reactive against NY-ESO-1, MART-1, gp100 and TYRP-1, were found in 12/23 pts expressing at least one of the HLA-A1, A2, -A3 or A24 alleles with induction or augmentation of TAA reactivity in the course of treatment. (bmj.com)

Importantly, we show for three different epitopes that MCC specific T cells are capable of killing target cells expressing Large T antigen, including HLA-matched MCC cell lines, indicating that these T cells could provide functional activity upon in vivo transfer, and thus be employed in adoptive T cell therapy for MCC. (biomedcentral.com)
T cell epitopes from Large T antigen of MCPyV display a large sequence variation with other polyomaviruses, but are highly conserved among different strains of MCPyV. (biomedcentral.com)
HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. (ox.ac.uk)
We show here that while tapasin is required for HLA-A*0201 (HLA-A2) molecules to bind to TAP, its absence does not block the presentation of HLA-A2-restricted TAP-dependent epitopes to cytotoxic T lymphocytes indicating that, unlike HLA-A1, HLA-B8 and HLA-B4402, HLA-A2 has access to the TAP-dependent peptide pool even in the absence of tapasin. (ox.ac.uk)
The vast majority of such strategies are based on tumor associated antigens (TAAs) which are shared wild type cellular self-epitopes highly expressed on tumor cells. (biomedcentral.com)

We show that the monocyte:macrophage balance is disrupted in colon inflammation to favour recruitment of CD14 + HLA-DR Int cells in humans, and Ly6C Hi monocytes in mice. (frontiersin.org)

At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 . (medlineplus.gov)
Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1 . (medlineplus.gov)
Other HLA haplotypes only mildly increase the risk of type 1 diabetes, while some haplotypes seem to protect against developing this condition. (medlineplus.gov)
Several HLA genes or haplotypes immunodeficiency virus (HIV) as of mid-1996 (1). (cdc.gov)
Human leukocyte antigen haplotypes and HFE mutations in Spanish hereditary hemochromatosis and sporadic porphyria cutanea tarda. (cdc.gov)

Two-point haplotype analysis between TNFB(B*01 allele) and HLA show that the allele is in linkage disequilibrium with HLA-A1, Cw7, B8, C4A(Null), DR3, DQ2.5. (wikipedia.org)
Comparison of HCV sequences from Asia and Europe suggests that the frequency of the HLA-A*01 allele in a population may influence the frequency of the escape variant in circulating strains. (ox.ac.uk)
Here is a map showing the allele frequency of HLA-DR14. (eupedia.com)
Here is a map showing the allele frequency of HLA-DR10. (eupedia.com)
Here is a map showing the allele frequency of HLA-A3, which is divided in two subtypes : A3:01 and A3:02. (eupedia.com)
Among the CD-IgA-D group, the B14 allele and A1, B8, Cw7, DR3, DQw2 haplotype were found to confer a high risk of developing IgA-D. A possible protective role may be postulated for DR2 and DR4 in both types of IgA-D patients. (nih.gov)

Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells. (uchc.edu)
Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors. (lookformedical.com)
Advances in understanding the role of dendritic cells (DCs) as the major antigen (Ag)-presenting cell type of the immune system combined with the recent development of methods for the ex vivo expansion of human DCs have opened the possibility for the transfer of tumor Ags to DCs with a view toward tumor immunotherapy. (lookformedical.com)
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)

The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response. (biomedcentral.com)
Tumor antigens can be classified into tumor-specific antigens (TSAs) and tumor-associated antigens (TAAs). (biomedcentral.com)
Vaccination with messenger RNA (mRNA) encoding full-length tumor antigens is a novel option for immunotherapy. (biomedcentral.com)

We have previously determined the structure of the MHC class I molecule HLA-A1 bound to a melanoma antigen-encoding gene (MAGE)-A1-derived peptide in complex with a recombinant antibody fragment with TCR-like specificity, Fab-Hyb3. (rcsb.org)
Patients and methods This phase-II trial investigated a peptide vaccination against survivin, an oncogenic inhibitor-of-apoptosis protein crucial for the survival of tumor cells, in HLA-A1/-A2/-B35-positive patients with treatment-refractory stage-IV metastatic melanoma. (uni-wuerzburg.de)
Activation induced cell death (AICD) of human melanoma antigen-specific TCR engineered CD8 T cells involves JNK, Bim and p53. (uchc.edu)
Death receptor-independent activation-induced cell death in human melanoma antigen-specific MHC class I-restricted TCR-engineered CD4 T cells. (uchc.edu)
In a phase I/II trial in patients with metastatic melanoma, direct intra-dermal injection of mRNA coding for relevant tumor-associated antigens was well tolerated and influenced the frequency of vaccine-antigen directed CD4 and CD8 T cells as well as regulatory T cells (T Regs). (biomedcentral.com)

A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
Genome-wide association studies (GWAS) performed in PSC have identified about 20 genes that are significantly associated with PSC, most of which localize within the human leukocyte antigen (HLA) complex. (medscape.com)
The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. (medlineplus.gov)
The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)
Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)
Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
The role of genes ceptibility to HIV infection and the course of HIV of the human leukocyte antigen (HLA) system in disease. (cdc.gov)
Chromosomal abnormalities, HLA phenotypes, and polymorphisms of various genes have been associated with acne. (springer.com)
Among the human genes whose inhibition was most strongly correlated with increased EBV gene expression were multiple MHC class I HLA genes involved in regulating immune response via antigen presentation. (gsea-msigdb.org)

In Europe A1-B8 is found, generally as part of the HLA A1-B8-DR3-DQ2 haplotype. (wikipedia.org)
Underlying this move was the HLA A1-B8-DR3-DQ2 haplotype, a haplotype that is in acute linkage disequilibrium in the European population. (wikipedia.org)
While type 1 diabetes shows an extended association on the HLA A1-B8-DR3-DQ2 haplotype, the association appears not to extend beyond the HLA-B locus. (wikipedia.org)
However, some of this reaction can be attributed to the linkage of the HLA A1-B8-DR3-DQ2 haplotype to the IgA-less phenotype. (wikipedia.org)
The strongest associations were seen with A1-Cw7-B8 haplotype. (wikipedia.org)
This locus in part of the HLA A1-B8-DR3-DQ2 haplotype (markers are A1, CW7, B8, BfS, C4AQ0, C4B1, DR3, DQ2) therefore one study concluded that C4AQ0 could explain the increased infectivity to HIV. (wikipedia.org)
The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 . (medlineplus.gov)
A solution devised by British scientists fifteen years ago is to find particular donors in the general population who possess what is called a "triple-homozygous haplotype", that is they only have one type of HLA-A antigen (the 2 A's are identical), one type of HLA-B antigen and only one type of HLA-DR antigen. (istem.eu)
We determined and published (in 2013) that the triple-homozygous donor alone with the most common haplotype in the Caucasian population (A1, B8, DR3: so it is A1A1, B8B8, DR3DR3) could serve up to 14.5 % of the population (heterozygotes A1Ax, B8By, DR3DRz) in France and in all countries of Caucasian population. (istem.eu)
The HLA-A1-B8 haplotype hitchhiking with the hemochromatosis mutation: does it affect the phenotype? (cdc.gov)

receptor B1 DB07268 (LILRB1) which binds dimeric HLA-G strongly. (biotech2012.org)

crystal structure of htlv-1 tax peptide bound to human class i mhc hla-a2 with the k66a mutation in the heavy chain. (berkeley.edu)

The aim of this study was to characterize the forces that contribute to viral evolution in an HLA-A*01-restricted epitope in HCV NS3. (ox.ac.uk)
In our cohort of subjects with chronic HCV infection (genotype 1b or 3a), it is a frequently recognized CD8 epitope in HLA-A*01-positive subjects. (ox.ac.uk)
The antibody MEM-61 recognizes an epitope on second extracellular domain (EC2) of CD9 antigen, a 24 kDa transmembrane protein expressed on platelets, monocytes, pre-B lymphocytes, granulocytes and activated T lymphocytes. (exbio.cz)
My main research interests are HLA epitope matching, the formation and detection of HLA-specific B cell memory, personalized medicine by definition of acceptable HLA mismatches and novel treatment options for sensitized patients. (lumc.nl)

The etiology of primary sclerosing cholangitis (PSC) remains unknown, but it is thought to be multifactorial, including genetic predisposition, exposure to an environmental antigen, and subsequent aberrant immunologic response to that stimulus. (medscape.com)
[ 16 ] A genetic predisposition has been suggested because of an increased prevalence of HLA-B8, HLA-DR3, and HLA-Drw52a. (medscape.com)

Human leukocyte antigen Cw7 was detected in 4 of 5 recipients, and the fifth case, the antigen was detected in the donor. (ectrx.org)
Polyoma BK virus-positive people can be accepted safely for kidney donation, especially with a possible protective role of human leukocyte antigen Cw7. (ectrx.org)
Limited expression of human being leucocyte antigen-G (HLA-G) to fetal extravillous trophoblast cells which invade the decidua during implantation suggests a role for HLA-G in placentation. (biotech2012.org)
Previous studies have shown the accumulation of human CD14 Hi or CD14 + HLA-DR Int cells in the GI tract lamina propria (LP) during inflammation ( 2 , 6 , 11 - 14 ). (frontiersin.org)
Indeed, the term "molecular mimicry" was originally introduced in 1964 to define the similarity between antigens expressed by infectious agents and human cells, as cause of the microbial escape from the host immune response and a more aggressive infection [ 14 ]. (biomedcentral.com)
Class I and II human leukocyte antigens were determined by a standard microlymphocytotoxity test in a group of 45 pediatric patients with selective immunoglobulin A deficiency (IgA-D), 33 of them with frequent respiratory tract infections, allergic diseases, or gastrointestinal disorders (RTIAG), and 12 with celiac disease (CD). (nih.gov)
bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)

Therefore, conformational changes within the HLA-A1:MAGE-A1:Fab-Hyb3 complex include MHC residues that are also involved in reorientations in complexes with natural ligands, pointing to their central importance for the peptide-dependent recognition of MHC molecules. (rcsb.org)
Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
Stöckl J, Majdic O, Fischer G, Maurer D, Knapp W: Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL. (exbio.cz)
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
Tapasin is a 48-kDa endoplasmic reticulum (ER)-resident glycoprotein that binds to the transporter associated with antigen processing (TAP) and mediates an interaction between TAP and newly synthesized MHC class I molecules. (ox.ac.uk)
Nevertheless, the overall efficiency with which HLA-A2 was loaded with optimal, stabilizing peptides was impaired in the cell line .220, resulting in a significant increase in the fraction of HLA-A2 molecules being released from the ER in a "peptide-receptive" state. (ox.ac.uk)

Evidence points toward a T-cell-mediated cytotoxic process directed against unidentified muscle antigens. (medscape.com)

We identified HLA-A*02:01/peptide-restricted T cells directed against ADRB3 295 . (oncotarget.com)
After TCR identification, we generated HLA-A*02:01/peptide restricted TCR transgenic T cells by retroviral transduction and tested T cell expansion rates as well as A*02:01/peptide recognition and ES killing in ELISpot and xCELLigence assays. (oncotarget.com)
Inefficient exogenous loading of a tapasin-dependent peptide onto HLA-B*44:02 can be improved by acid treatment or fixation of target cells. (ox.ac.uk)
Here, we identify an antigenic peptide, which is derived from the MAGE-A1-encoded protein (160-169) and presented to CTLs by HLA-B*44:02. (ox.ac.uk)
Although this peptide is encoded by MAGE-A1, processed endogenously and presented by tumor cells, the corresponding synthetic peptide is hardly able to sensitize target cells to CTL recognition when pulsed exogenously. (ox.ac.uk)
Endogenous processing and presentation of this peptide is strictly dependent on the presence of tapasin, which is believed to help peptide loading by stabilizing a peptide-receptive form of HLA-B*44:02. (ox.ac.uk)
Either strategy allows efficient exogenous loading of the peptide, presumably by generating or stabilizing a peptide-receptive, empty conformation of the HLA. (ox.ac.uk)

HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
TSAs arise from cancer-related nonsynonymous mutations or other genetic alterations, which give rise to mutated peptides presented by HLA only on the cell surface of tumor cells (neoantigens). (biomedcentral.com)

HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
IL-8 production was primarily seen in HLA-DR+ cells which are predominantly macrophages in our decidual leucocyte preparations (Gardner and Moffett 2003 IFN-γ was produced after 6 h stimulation with PMA confirming that dNK cells can produce this cytokine. (biotech2012.org)
however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)

A1-B8 associated with more rapid progression to seropositivity, and was strongly associated with a rapid decline in T4 cells and development of HIV-related symptoms within four years of infection. (wikipedia.org)
Compared to other prostate cancer cell models, PC3 cells have low testosterone-5-alpha reductase and acidic phosphatase activity and do not express the prostate-specific antigen (PSA). (cytion.com)
Pre- hematopoietic and other cells, but the Duffy sence of one copy of the deleted CCR5 gene also antigen of erythrocytes (DARC) is the only influences the course of disease as the onset of member expressed on cells of erythroid lineage. (cdc.gov)
Afterwards, I returned to Leiden to work as a senior postdoctoral scientist on the detection of HLA-specific memory B cells and the role of B cells in transplant rejection. (lumc.nl)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
We then measured functional DB07268 reactions of dNK cells with LILRB1 when stimulated by HLA-G in both monomeric and dimeric conformations. (biotech2012.org)
Degranulation interferon-γ and interleukin-8 production by dNK cells freshly isolated from your 1st trimester implantation site were either undetected or not affected by HLA-G. These findings should be considered when inferring the activity of cells NK cells from results acquired with cell lines peripheral NK or cultured dNK cells. (biotech2012.org)
Pulse chase and immunoprecipitation 721.221 cells transfected with HLA-G were starved for 30 min in the medium lacking cysteine and methionine labelled for 20 min with 0.1 mCi/ml l-[35S]methionine and l-[35S]cysteine (Promix GE Healthcare) and chased in a regular medium for the indicated times. (biotech2012.org)
Given these indications that the reported findings of IFN-γ and IL-8 production by dNK cells are in response to stimulation we tested dNK cell degranulation when cultured with HLA class I-null target cells (Fig.?4C). (biotech2012.org)
Decidual leucocytes from normal first trimester pregnancies were analysed immediately after isolation by intracellular flow cytometry for the production of IFN-γ … We then sought to investigate modulation by HLA-G of dNK cell degranulation responses to target cells. (biotech2012.org)
Neither monomeric nor dimeric forms of HLA-G affected degranulation of dNK cells (Fig.?5D). (biotech2012.org)
Degranulation of PBNK cells was inhibited by HLA-G consistent with previous reports (Perez-Villar by flow cytometry on EVT cells isolated from 70 normal first trimester pregnancies. (biotech2012.org)
Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
TCR transgenic T cells demonstrated HLA-A*02:01/ADRB3 295 mediated ES recognition and killing in ELISpot and xCELLigence assays. (oncotarget.com)
Amino-acid exchange scans clearly indicated the cross-reactive potential of HLA-A*02:01/ADRB3 295 - and HLA-A*02:01/CHM1 319 -TCR transgenic T cells. (oncotarget.com)
On the contrary, TAAs are wild-type self-antigens highly expressed on tumor cells compared to corresponding normal cells. (biomedcentral.com)
The association between EBV gene expression and inhibition of MHC class I HLA expression implies that antigen display is either directly inhibited by EBV, facilitating immune evasion by tumor cells, and/or that tumor cells with inhibited presentation are selected for their ability to sustain higher levels of EBV to take maximum advantage of EBV oncogene-mediated tumor-promoting actions. (gsea-msigdb.org)
Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)

The following product was used in this experiment: HLA-DR Monoclonal Antibody (LN3), Super Bright™ 436, eBioscience™ from Thermo Fisher Scientific, catalog # 62-9956-42, RRID AB_2744822. (thermofisher.com)

Peripheral blood lymphocytes (PBMC) and sera were collected at baseline, wk12, and wk24 to perform phenotypic and functional T cell assays, and to investigate humoral responses against a panel of tumor-associated antigens (TAAs) and soluble NKG2D ligands (sNKG2DL). (bmj.com)
Therefore, overcoming such limitations is a major goal, given that TAAs represent the most suitable target antigens for developing cancer vaccines on a large scale. (biomedcentral.com)
However, the exploitation of homology between TAAs and antigens derived from microorganisms (MoAs) (molecular mimicry) may provide the most effective results. (biomedcentral.com)

Therefore, the most plausible concept of the pathogenesis of PSC involves the exposure of genetically predisposed individuals to an environmental antigen that subsequently elicits an aberrant immune response, leading to development of the disease. (medscape.com)

The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1 . (medlineplus.gov)

It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*0801 (HLA-B8) and HLA-B*4402 (HLA-B4402). (ox.ac.uk)

The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. (medlineplus.gov)
We investigated the T cell recognition of both the oncogenic proteins, Large and Small T antigen and the capsid protein VP1 that is profoundly expressed also in the non-symptomatic MCPyV infected healthy individuals. (biomedcentral.com)
Our data clearly reflect such tumor promotion, showing that deregulation of key proteins involved in apoptosis (BCL2-related protein A1 and Fas apoptotic inhibitory molecule), cell cycle checkpoints (AKIP, SCYL1, and NIN), and metastasis (matrix metalloproteinase 1) is closely correlated with the levels of EBV gene expression in NPC. (gsea-msigdb.org)

Here, we compare the X-ray structure of HLA-A1:MAGE-A1 with that complexed with Fab-Hyb3 to gain insight into structural changes of the MHC molecule that might be induced by the interaction with the antibody fragment. (rcsb.org)
The predominant Y1444F substitution seemingly impairs binding to the HLA-A*01 molecule, which may have an important impact on the ability to prime a functional CD8 response upon infection. (ox.ac.uk)

The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)

Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)

Numerous T cell responses were detected against MCPyV in both healthy donors and MCC patients, with a striking observation that T cell responses against Large and Small T antigens were found exclusively in MCC patients, suggesting that these oncoproteins are only presented to the immune system in the tumor-bearing host and represent highly specific targets for cancer immunotherapy of MCC. (biomedcentral.com)

In a previous study we introduced the concept of molecular groups of carcinoids: A1, A2, and B, which, importantly, contained a mixture of the two histological types. (who.int)

The "HL-A1,8 phenotype" was found to be associated with severe systemic lupus erythematosus (SLE) (renal and central nervous system involvement) in Caucasian patients. (wikipedia.org)

We investigated the T cell recognition of 398 in silico predicted HLA-ligands from Large T, Small T and VP1 and identified T-cell responses restricted to HLA-A1, A2, A3, A11 and B7. (biomedcentral.com)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
NK cell degranulation by IL-15-stimulated dNK was compared in response to 721.221 transfectants expressing HLA-G (Fig.?5). (biotech2012.org)
The cell-based therapeutic vaccine Sipuleucel T targeting the antigen PAP has been approved by the US Food and Drug Administration in 2010 and recently by the European Medicines Agency for the treatment of asymptomatic - minimally symptomatic metastatic CRPC based on a median prolongation in overall survival by 4.1 months compared to placebo controls [ 4 ]. (biomedcentral.com)

Though, the association of A1 with autoimmune hepatitis with no anti-viral antibody was stronger than with chronic active hepatitis with anti-viral titer. (wikipedia.org)

Furthermore, I am counselor of the International HLA and Immunogenetics Workshop (IHIWS), and co-organiser of the 18th IHIWS , to be held in Amsterdam in 2022. (lumc.nl)

This has been mainly attributed to immune escape by antigen loss, rendering us in the need of new vaccination targets. (uni-wuerzburg.de)
The follow-up vaccine CV9104 including the additional antigens prostatic acid phosphatase (PAP) and Muc1 is currently being tested in a randomized phase IIb trial to assess the clinical benefit induced by this new vaccination approach. (biomedcentral.com)

Despite the fact that the associations have been known almost as long as A1 and "A8" were known, the role of factors affecting disease are still not clear. (wikipedia.org)
In allergic disease A1,B8 were found to associate with allergic reactions in new-borns. (wikipedia.org)

The primary endpoint was safety and tolerability, the secondary endpoint was induction of antigen specific immune responses monitored at baseline and at weeks 5, 9 and 17. (biomedcentral.com)

An association was seen between viral hepatitis and HLA-A1. (wikipedia.org)

exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)

Further asthmatic patients with negative skin tests tended toward higher A1,B8 serotypes. (wikipedia.org)
Methods Flow cytometer from American BD company was used to test the express levels of HLA-B27 from 95 patients with AS, 226 non-AS patients, and 50 healthy control. (39kf.com)
Results According to the critical value of BD (≥147)，there were only 58 positive cases (61.05％) in AS group and there were 17 AS patients whose HLA-B27 levels were between 140 and 146, there were 11 positive case (4.87%) in non-AS group, and there were 3 positive cases (6.00％) in healthy group. (39kf.com)
CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)
A total of 26/33 evaluable patients treated at 1280 μg developed an immune response, directed against multiple antigens in 15 out of 33 patients. (biomedcentral.com)

Subjects presenting with both CD and DH generally show an HLA pattern in which A1, B8, DR2, DR7, DQw2 are the most frequent antigens one can find. (unipr.it)

Circulation cytometry Monoclonal antibodies (mAbs) used in this study to bind HLA-G were G233 (Loke (1993) by amplifying a 141 or 155 bp region spanning the polymorphism using the primers 5′-GTAGTGTGAAACAGCTGCCC-3′ and 5′-AAGGAATGCAGTTCAGCATGA-3′ and resolving products by electrophoresis having a 3% low-melting-point agarose gel. (biotech2012.org)

Anatomy23

Organisms8

Diseases6

Chemicals and Drugs152

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes36

Disciplines and Occupations1

Information Science3

Health Care3

Histocompatibility11

Alleles6

Epitopes5

Humans1

Haplotypes6

Allele6

Dendritic cells7

Tumor antigens3

Melanoma5

Genes12

Haplotype10

Receptor1

Mutation1

Epitope4

Genetic predisposition2

Human7

Molecules6

Cytotoxic1

Peptide7

Peptides2

Macrophages3

Cells19

Monoclonal Antibody1

TAAs3

Elicits1

Binds1

08011

Protein4

Molecule2

Proteins1

Loci1

Donors1

Molecular1

Renal1

Cell4

Autoimmune hepatitis1

20221

Vaccination2

Disease2

Responses1

Viral1

Exogenous1

Patients5

DQw21

Bind1